The following articles (labelled with PubMed ID or TBD) are for your review
| PMID | Data | Article Title | Organization |
|---|
| 28279529 |
8 |
Soluble epoxide hydrolase inhibitors of indolinone alkaloids and phenolic derivatives from Cimicifuga dahurica (Turcz.) Maxim. |
Chungnam National University |
| 27120257 |
8 |
Rational Design of Potent and Selective Inhibitors of an Epoxide Hydrolase Virulence Factor from Pseudomonas aeruginosa. |
University of California |
| 27096037 |
8 |
Stacking with No Planarity? |
Merck |
| 27092411 |
22 |
Discovery of enantioselectivity of urea inhibitors of soluble epoxide hydrolase. |
Chungnam National University |
| 26595749 |
77 |
N-Benzylbenzamides: A Novel Merged Scaffold for Orally Available Dual Soluble Epoxide Hydrolase/Peroxisome Proliferator-Activated Receptor¿ Modulators. |
Goethe-University Frankfurt |
| 26520661 |
18 |
1,3-Disubstituted and 1,3,3-trisubstituted adamantyl-ureas with isoxazole as soluble epoxide hydrolase inhibitors. |
University of California Davis |
| 26483136 |
12 |
Constituents of the seeds of Cassia tora with inhibitory activity on soluble expoxide hydrolease. |
Chungnam National University |
| 26507430 |
36 |
Structure-activity relationships of amide-phosphonate derivatives as inhibitors of the human soluble epoxide hydrolase. |
Ehime University |
| 26372074 |
17 |
Soluble epoxide hydrolase inhibitory activity of anthraquinone components from Aloe. |
Chungnam National University |
| 25079952 |
38 |
Optimized inhibitors of soluble epoxide hydrolase improve in vitro target residence time and in vivo efficacy. |
University of California Davis |
| 25862210 |
9 |
Identification of N-ethylmethylamine as a novel scaffold for inhibitors of soluble epoxide hydrolase by crystallographic fragment screening. |
Astellas Pharma |
| 25800114 |
20 |
Three-dimensional rational approach to the discovery of potent substituted cyclopropyl urea soluble epoxide hydrolase inhibitors. |
Sumitomo Dainippon Pharma |
| 25119815 |
33 |
14,15-Epoxyeicosa-5,8,11-trienoic Acid (14,15-EET) surrogates: carboxylate modifications. |
University of Texas Southwestern Medical Center |
| 24685540 |
28 |
Symmetric adamantyl-diureas as soluble epoxide hydrolase inhibitors. |
Volzhsky Polytechnic Institute (Branch) Volgograd State Technical University |
| 24679441 |
16 |
Anti-inflammatory components of Euphorbia humifusa Willd. |
Chungnam National University |
| 24656800 |
11 |
Structural insights into binding of inhibitors to soluble epoxide hydrolase gained by fragment screening and X-ray crystallography. |
Astellas Pharma |
| 24422550 |
107 |
Optimization of brain penetrant 11ß-hydroxysteroid dehydrogenase type I inhibitors and in vivo testing in diet-induced obese mice. |
Astrazeneca |
| 24530032 |
65 |
Structure-based optimization of cyclopropyl urea derivatives as potent soluble epoxide hydrolase inhibitors for potential decrease of renal injury without hypotensive action. |
Dainippon Sumitomo Pharma |
| 24373724 |
47 |
Discovery of 1-oxa-4,9-diazaspiro[5.5]undecane-based trisubstituted urea derivatives as highly potent soluble epoxide hydrolase inhibitors and orally active drug candidates for treating of chronic kidney diseases. |
Toray Industries |
| 24433964 |
30 |
Structure-activity relationships of substituted oxyoxalamides as inhibitors of the human soluble epoxide hydrolase. |
Ehime University |
| 24900624 |
18 |
Exploring the chemical space of multitarget ligands using aligned self-organizing maps. |
Goethe University |
| 24035338 |
82 |
Discovery of 2,8-diazaspiro[4.5]decane-based trisubstituted urea derivatives as highly potent soluble epoxide hydrolase inhibitors and orally active drug candidates for treating hypertension. |
Toray Industries |
| 23726028 |
20 |
Synthesis and biological evaluation of sorafenib- and regorafenib-like sEH inhibitors. |
University of California |
| 23684894 |
12 |
Inhibition of soluble epoxide hydrolase by fulvestrant and sulfoxides. |
University of California |
| 23664879 |
73 |
Discovery of 1-(1,3,5-triazin-2-yl)piperidine-4-carboxamides as inhibitors of soluble epoxide hydrolase. |
Glaxosmithkline |
| 23498915 |
47 |
Design, synthesis and anti-tuberculosis activity of 1-adamantyl-3-heteroaryl ureas with improved in vitro pharmacokinetic properties. |
St. Jude Children'S Research Hospital |
| 23489630 |
8 |
Synthesis and biological activity of 4-substituted benzoxazolone derivatives as a new class of sEH inhibitors with high anti-inflammatory activity in vivo. |
Shanxi Medical University |
| 23356879 |
50 |
Synthesis and structure-activity relationship studies of novel dual inhibitors of soluble epoxide hydrolase and 5-lipoxygenase. |
Goethe-University Frankfurt |
| 23237835 |
46 |
Synthesis and structure-activity relationship of piperidine-derived non-urea soluble epoxide hydrolase inhibitors. |
Columbia University |
| 23130964 |
25 |
Design and synthesis of dual modulators of soluble epoxide hydrolase and peroxisome proliferator-activated receptors. |
Zafes/Liff/Osf Goethe-University Frankfurt |
| 21354674 |
14 |
The many faces of the adamantyl group in drug design. |
University of Sydney |
| 23017883 |
4 |
Evaluation of structure-derived pharmacophore of soluble epoxide hydrolase inhibitors by virtual screening. |
Johann Wolfgang Goethe University |
| 22901393 |
11 |
Biologically active ester derivatives as potent inhibitors of the soluble epoxide hydrolase. |
University of California |
| 24900445 |
10 |
Dual-target virtual screening by pharmacophore elucidation and molecular shape filtering. |
TBA |
| 22522007 |
102 |
Screening a library of 1600 adamantyl ureas for anti-Mycobacterium tuberculosis activity in vitro and for better physical chemical properties for bioavailability. |
Colorado State University |
| 21192659 |
16 |
A practical use of ligand efficiency indices out of the fragment-based approach: ligand efficiency-guided lead identification of soluble epoxide hydrolase inhibitors. |
Dainippon Sumitomo Pharma |
| 19645482 |
245 |
Discovery of a highly potent, selective, and bioavailable soluble epoxide hydrolase inhibitor with excellent ex vivo target engagement. |
Merck Research Laboratories |
| 17616115 |
61 |
Orally bioavailable potent soluble epoxide hydrolase inhibitors. |
University of California Davis |
| 22079754 |
72 |
Design, synthesis and evaluation of non-urea inhibitors of soluble epoxide hydrolase. |
Columbia University |
| 21840723 |
50 |
The structure-activity relationship of urea derivatives as anti-tuberculosis agents. |
St. Jude Children'S Research Hospital |
| 21434686 |
48 |
Synthesis and structure-activity relationship studies of urea-containing pyrazoles as dual inhibitors of cyclooxygenase-2 and soluble epoxide hydrolase. |
University of California |
| 21211973 |
35 |
1-(1-acetyl-piperidin-4-yl)-3-adamantan-1-yl-urea (AR9281) as a potent, selective, and orally available soluble epoxide hydrolase inhibitor with efficacy in rodent models of hypertension and dysglycemia. |
Ar£Te Therapeutics |
| 21070033 |
42 |
Incorporation of Piperazino Functionality into 1,3-Disubstituted Urea as the Tertiary Pharmacophore Affording Potent Inhibitors of Soluble Epoxide Hydrolase with Improved Pharmacokinetic Properties |
TBA |
| 20934334 |
16 |
Substituted pyrazoles as novel sEH antagonist: investigation of key binding interactions within the catalytic domain. |
Boehringer Ingelheim Pharmaceuticals |
| 20812725 |
103 |
1-Aryl-3-(1-acylpiperidin-4-yl)urea inhibitors of human and murine soluble epoxide hydrolase: structure-activity relationships, pharmacokinetics, and reduction of inflammatory pain. |
Department of Entomology and University of California Davis Cancer Center |
| 20472432 |
29 |
Rapid synthesis of an array of trisubstituted urea-based soluble epoxide hydrolase inhibitors facilitated by a novel solid-phase method. |
Boehringer Ingelheim Pharmaceuticals |
| 20363133 |
67 |
Exploration of secondary and tertiary pharmacophores in unsymmetrical N,N'-diaryl urea inhibitors of soluble epoxide hydrolase. |
Ar£Te Therapeutics |
| 19682899 |
211 |
Discovery of 3,3-disubstituted piperidine-derived trisubstituted ureas as highly potent soluble epoxide hydrolase inhibitors. |
Merck Research Laboratories |
| 19969453 |
73 |
Optimization of piperidyl-ureas as inhibitors of soluble epoxide hydrolase. |
Boehringer Ingelheim Pharmaceuticals |
| 19758802 |
56 |
Design and synthesis of substituted nicotinamides as inhibitors of soluble epoxide hydrolase. |
Boehringer Ingelheim Pharmaceuticals |
| 19700315 |
68 |
A strategy of employing aminoheterocycles as amide mimics to identify novel, potent and bioavailable soluble epoxide hydrolase inhibitors. |
Merck Research Laboratories |
| 19746975 |
67 |
Structure-based optimization of arylamides as inhibitors of soluble epoxide hydrolase. |
Boehringer Ingelheim Pharmaceuticals |
| 19520575 |
49 |
Unsymmetrical non-adamantyl N,N'-diaryl urea and amide inhibitors of soluble expoxide hydrolase. |
Arete Therapeutics |
| 19653681 |
29 |
14,15-Epoxyeicosa-5,8,11-trienoic acid (14,15-EET) surrogates containing epoxide bioisosteres: influence upon vascular relaxation and soluble epoxide hydrolase inhibition. |
University of Texas Southwestern Medical Center |
| 19481932 |
164 |
Discovery of spirocyclic secondary amine-derived tertiary ureas as highly potent, selective and bioavailable soluble epoxide hydrolase inhibitors. |
Merck Research Laboratories |
| 19303288 |
41 |
Discovery of potent non-urea inhibitors of soluble epoxide hydrolase. |
Columbia University |
| 19216074 |
30 |
Salicylate-urea-based soluble epoxide hydrolase inhibitors with high metabolic and chemical stabilities. |
Department of Entomology and University of California Davis Cancer Center |
| 19168352 |
29 |
Non-urea functionality as the primary pharmacophore in soluble epoxide hydrolase inhibitors. |
ArêTe Therapeutics |
| 17894481 |
29 |
1,3-disubstituted ureas functionalized with ether groups are potent inhibitors of the soluble epoxide hydrolase with improved pharmacokinetic properties. |
Department of Entomology and University of California Davis Cancer Center |
| 17046265 |
66 |
Design of bioavailable derivatives of 12-(3-adamantan-1-yl-ureido)dodecanoic acid, a potent inhibitor of the soluble epoxide hydrolase. |
Department of Entomology and University of California Davis Cancer Center |
| 16949285 |
18 |
Solid-phase combinatorial approach for the optimization of soluble epoxide hydrolase inhibitors. |
University of California |
| 16908134 |
98 |
Peptidyl-urea based inhibitors of soluble epoxide hydrolases. |
University of California |
| 16870439 |
47 |
Synthesis and SAR of conformationally restricted inhibitors of soluble epoxide hydrolase. |
University of California |
| 15887969 |
64 |
Optimization of amide-based inhibitors of soluble epoxide hydrolase with improved water solubility. |
Department of Entomology and University of California Davis Cancer Center |
| 15056008 |
72 |
Design, synthesis, and biological activity of 1,3-disubstituted ureas as potent inhibitors of the soluble epoxide hydrolase of increased water solubility. |
University of California Davis |
| 12620084 |
17 |
QSAR and classification of murine and human soluble epoxide hydrolase inhibition by urea-like compounds. |
The Pennsylvania State University |
| 32551007 |
19 |
Computer-Aided Fragment Growing Strategies to Design Dual Inhibitors of Soluble Epoxide Hydrolase and LTA4 Hydrolase. |
Goethe-University |
| 32039601 |
14 |
DNA-Encoded Library Screening as Core Platform Technology in Drug Discovery: Its Synthetic Method Development and Applications in DEL Synthesis. |
Daegu-Gyeongbuk Medical Innovation Foundation (Dgmif) |
| 31870649 |
34 |
Imidazolidine-2,4,5- and pirimidine-2,4,6-triones - New primary pharmacophore for soluble epoxide hydrolase inhibitors with enhanced water solubility. |
University of California Davis |
| 27545443 |
22 |
Challenges of docking in large, flexible and promiscuous binding sites. |
The Barcelona Institute For Research In Biomedicine (Irb Barcelona) |
| 26914744 |
24 |
Chemical Space of DNA-Encoded Libraries. |
University of Utah |
| 31436984 |
54 |
Discovery of the First in Vivo Active Inhibitors of the Soluble Epoxide Hydrolase Phosphatase Domain. |
Goethe-University Frankfurt |
| 31488357 |
19 |
Exploring the size of the lipophilic unit of the soluble epoxide hydrolase inhibitors. |
Universitat De Barcelona |
| 30655948 |
42 |
Synthesis, Biological Evaluation and Structure-Activity Relationships of Diflapolin Analogues as Dual sEH/FLAP Inhibitors. |
University of Innsbruck |
| 31009912 |
5 |
Multitarget PPAR? agonists as innovative modulators of the metabolic syndrome. |
University of Chieti "G. D.Annunzio |
| 31009908 |
28 |
Research progress in the biological activities of 3,4,5-trimethoxycinnamic acid (TMCA) derivatives. |
Northwest University |
| 32184960 |
34 |
Design of Dual Inhibitors of Soluble Epoxide Hydrolase and LTA |
Goethe University Frankfurt |
| 31223445 |
4 |
Computer-Aided Selective Optimization of Side Activities of Talinolol. |
Goethe-University of Frankfurt |
| 25225606 |
22 |
Structure-based optimization of the piperazino-containing 1,3-disubstituted ureas affording sub-nanomolar inhibitors of soluble epoxide hydrolase. |
Chinese Academy of Sciences |
| 30354105 |
3 |
NMR-Based Investigation of Hydrogen Bonding in a Dihydroanthracen-1(4 H)one from Rubia philippinensis and Its Soluble Epoxide Hydrolase Inhibitory Potential. |
Yale University |
| 29878767 |
21 |
Boosting Anti-Inflammatory Potency of Zafirlukast by Designed Polypharmacology. |
Goethe University Frankfurt |
| 28558206 |
11 |
Inhibition Potential of Cycloartane-Type Glycosides from the Roots of Cimicifuga dahurica against Soluble Epoxide Hydrolase. |
Chungnam National University |
| 29366648 |
98 |
Identification and optimization of soluble epoxide hydrolase inhibitors with dual potency towards fatty acid amide hydrolase. |
University of California Davis |
| 29803731 |
68 |
Adamantyl thioureas as soluble epoxide hydrolase inhibitors. |
University of California Davis |
| 29614224 |
27 |
Orally Available Soluble Epoxide Hydrolase/Phosphodiesterase 4 Dual Inhibitor Treats Inflammatory Pain. |
University of California Davis |
| 28845983 |
81 |
A Dual Modulator of Farnesoid X Receptor and Soluble Epoxide Hydrolase To Counter Nonalcoholic Steatohepatitis. |
Goethe-University Frankfurt |
| 10455277 |
9 |
Ligand efficacy and potency at recombinant human MT2 melatonin receptors: evidence for agonist activity of some mt1-antagonists. |
Universit&Agrove |
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