Found 56 hits of Enzyme Inhibition Constant Data Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Bifunctional epoxide hydrolase 2
(Homo sapiens (Human)) | BDBM50302462
(CHEMBL566648 | N-(4-bromo-2-(trifluoromethoxy)benz...)Show SMILES FC(F)(F)CCOc1ccc(cn1)C(=O)NCc1ccc(Br)cc1OC(F)(F)F Show InChI InChI=1S/C17H13BrF6N2O3/c18-12-3-1-10(13(7-12)29-17(22,23)24)8-26-15(27)11-2-4-14(25-9-11)28-6-5-16(19,20)21/h1-4,7,9H,5-6,8H2,(H,26,27) | PDB
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| CHEMBL
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| n/a | n/a | 0.100 | n/a | n/a | n/a | n/a | n/a | n/a |
Boehringer Ingelheim Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of soluble EH in human HepG2 cells by cellular assay |
Bioorg Med Chem Lett 19: 5864-8 (2009)
Article DOI: 10.1016/j.bmcl.2009.08.074
BindingDB Entry DOI: 10.7270/Q27944SC |
More data for this
Ligand-Target Pair | |
Bifunctional epoxide hydrolase 2
(Homo sapiens (Human)) | BDBM50302475
(CHEMBL567491 | N-(3,3-diphenylpropyl)-1-(2-ethoxye...)Show SMILES CCOCCn1cc(ccc1=O)C(=O)NCCC(c1ccccc1)c1ccccc1 Show InChI InChI=1S/C25H28N2O3/c1-2-30-18-17-27-19-22(13-14-24(27)28)25(29)26-16-15-23(20-9-5-3-6-10-20)21-11-7-4-8-12-21/h3-14,19,23H,2,15-18H2,1H3,(H,26,29) | PDB
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| n/a | n/a | 2.60 | n/a | n/a | n/a | n/a | n/a | n/a |
Boehringer Ingelheim Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of human soluble EH |
Bioorg Med Chem Lett 19: 5864-8 (2009)
Article DOI: 10.1016/j.bmcl.2009.08.074
BindingDB Entry DOI: 10.7270/Q27944SC |
More data for this
Ligand-Target Pair | |
Bifunctional epoxide hydrolase 2
(Rattus norvegicus) | BDBM50302475
(CHEMBL567491 | N-(3,3-diphenylpropyl)-1-(2-ethoxye...)Show SMILES CCOCCn1cc(ccc1=O)C(=O)NCCC(c1ccccc1)c1ccccc1 Show InChI InChI=1S/C25H28N2O3/c1-2-30-18-17-27-19-22(13-14-24(27)28)25(29)26-16-15-23(20-9-5-3-6-10-20)21-11-7-4-8-12-21/h3-14,19,23H,2,15-18H2,1H3,(H,26,29) | PDB
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| n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
Boehringer Ingelheim Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of rat sEH |
Bioorg Med Chem Lett 19: 5864-8 (2009)
Article DOI: 10.1016/j.bmcl.2009.08.074
BindingDB Entry DOI: 10.7270/Q27944SC |
More data for this
Ligand-Target Pair | |
Bifunctional epoxide hydrolase 2
(Rattus norvegicus) | BDBM50302461
(CHEMBL567703 | N-((4'-(methylsulfonyl)biphenyl-4-y...)Show SMILES CS(=O)(=O)c1ccc(cc1)-c1ccc(CNC(=O)c2ccc(OCCC(F)(F)F)nc2)cc1 Show InChI InChI=1S/C23H21F3N2O4S/c1-33(30,31)20-9-6-18(7-10-20)17-4-2-16(3-5-17)14-28-22(29)19-8-11-21(27-15-19)32-13-12-23(24,25)26/h2-11,15H,12-14H2,1H3,(H,28,29) | PDB
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| n/a | n/a | 4.30 | n/a | n/a | n/a | n/a | n/a | n/a |
Boehringer Ingelheim Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of rat sEH |
Bioorg Med Chem Lett 19: 5864-8 (2009)
Article DOI: 10.1016/j.bmcl.2009.08.074
BindingDB Entry DOI: 10.7270/Q27944SC |
More data for this
Ligand-Target Pair | |
Bifunctional epoxide hydrolase 2
(Homo sapiens (Human)) | BDBM50302464
(CHEMBL567110 | N-(2-(trifluoromethoxy)benzyl)-6-(3...)Show SMILES FC(F)(F)CCOc1ccc(cn1)C(=O)NCc1ccccc1OC(F)(F)F Show InChI InChI=1S/C17H14F6N2O3/c18-16(19,20)7-8-27-14-6-5-12(10-24-14)15(26)25-9-11-3-1-2-4-13(11)28-17(21,22)23/h1-6,10H,7-9H2,(H,25,26) | PDB
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| n/a | n/a | 4.60 | n/a | n/a | n/a | n/a | n/a | n/a |
Boehringer Ingelheim Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of human soluble EH |
Bioorg Med Chem Lett 19: 5864-8 (2009)
Article DOI: 10.1016/j.bmcl.2009.08.074
BindingDB Entry DOI: 10.7270/Q27944SC |
More data for this
Ligand-Target Pair | |
Bifunctional epoxide hydrolase 2
(Homo sapiens (Human)) | BDBM50302473
(CHEMBL565628 | N-(3,3-diphenylpropyl)-6-(2,2,2-tri...)Show SMILES FC(F)(F)COc1ccc(cn1)C(=O)NCCC(c1ccccc1)c1ccccc1 Show InChI InChI=1S/C23H21F3N2O2/c24-23(25,26)16-30-21-12-11-19(15-28-21)22(29)27-14-13-20(17-7-3-1-4-8-17)18-9-5-2-6-10-18/h1-12,15,20H,13-14,16H2,(H,27,29) | PDB
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| n/a | n/a | 5.40 | n/a | n/a | n/a | n/a | n/a | n/a |
Boehringer Ingelheim Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of human soluble EH |
Bioorg Med Chem Lett 19: 5864-8 (2009)
Article DOI: 10.1016/j.bmcl.2009.08.074
BindingDB Entry DOI: 10.7270/Q27944SC |
More data for this
Ligand-Target Pair | |
Bifunctional epoxide hydrolase 2
(Rattus norvegicus) | BDBM50302476
(CHEMBL567283 | N-(2,4-dichlorobenzyl)-1-(2-ethoxye...)Show InChI InChI=1S/C17H18Cl2N2O3/c1-2-24-8-7-21-11-13(4-6-16(21)22)17(23)20-10-12-3-5-14(18)9-15(12)19/h3-6,9,11H,2,7-8,10H2,1H3,(H,20,23) | PDB
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Boehringer Ingelheim Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of rat sEH |
Bioorg Med Chem Lett 19: 5864-8 (2009)
Article DOI: 10.1016/j.bmcl.2009.08.074
BindingDB Entry DOI: 10.7270/Q27944SC |
More data for this
Ligand-Target Pair | |
Bifunctional epoxide hydrolase 2
(Rattus norvegicus) | BDBM50302464
(CHEMBL567110 | N-(2-(trifluoromethoxy)benzyl)-6-(3...)Show SMILES FC(F)(F)CCOc1ccc(cn1)C(=O)NCc1ccccc1OC(F)(F)F Show InChI InChI=1S/C17H14F6N2O3/c18-16(19,20)7-8-27-14-6-5-12(10-24-14)15(26)25-9-11-3-1-2-4-13(11)28-17(21,22)23/h1-6,10H,7-9H2,(H,25,26) | PDB
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| n/a | n/a | 6 | n/a | n/a | n/a | n/a | n/a | n/a |
Boehringer Ingelheim Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of rat sEH |
Bioorg Med Chem Lett 19: 5864-8 (2009)
Article DOI: 10.1016/j.bmcl.2009.08.074
BindingDB Entry DOI: 10.7270/Q27944SC |
More data for this
Ligand-Target Pair | |
Bifunctional epoxide hydrolase 2
(Homo sapiens (Human)) | BDBM50302474
(CHEMBL572205 | N-(2,4-dichlorobenzyl)-6-(2,2,2-tri...)Show InChI InChI=1S/C15H11Cl2F3N2O2/c16-11-3-1-9(12(17)5-11)6-22-14(23)10-2-4-13(21-7-10)24-8-15(18,19)20/h1-5,7H,6,8H2,(H,22,23) | PDB
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| n/a | n/a | 6.60 | n/a | n/a | n/a | n/a | n/a | n/a |
Boehringer Ingelheim Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of human soluble EH |
Bioorg Med Chem Lett 19: 5864-8 (2009)
Article DOI: 10.1016/j.bmcl.2009.08.074
BindingDB Entry DOI: 10.7270/Q27944SC |
More data for this
Ligand-Target Pair | |
Bifunctional epoxide hydrolase 2
(Homo sapiens (Human)) | BDBM50297413
(CHEMBL560537 | N-(3,3-diphenyl-propyl)-nicotinamid...)Show InChI InChI=1S/C21H20N2O/c24-21(19-12-7-14-22-16-19)23-15-13-20(17-8-3-1-4-9-17)18-10-5-2-6-11-18/h1-12,14,16,20H,13,15H2,(H,23,24) | PDB
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| n/a | n/a | 7 | n/a | n/a | n/a | n/a | n/a | n/a |
Boehringer Ingelheim Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of human soluble EH |
Bioorg Med Chem Lett 19: 5864-8 (2009)
Article DOI: 10.1016/j.bmcl.2009.08.074
BindingDB Entry DOI: 10.7270/Q27944SC |
More data for this
Ligand-Target Pair | 
3D Structure (crystal) |
Bifunctional epoxide hydrolase 2
(Rattus norvegicus) | BDBM50302471
(CHEMBL565841 | N-(4-chlorobenzyl)-6-(3,3,3-trifluo...)Show InChI InChI=1S/C16H14ClF3N2O2/c17-13-4-1-11(2-5-13)9-22-15(23)12-3-6-14(21-10-12)24-8-7-16(18,19)20/h1-6,10H,7-9H2,(H,22,23) | PDB
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| n/a | n/a | 7 | n/a | n/a | n/a | n/a | n/a | n/a |
Boehringer Ingelheim Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of rat sEH |
Bioorg Med Chem Lett 19: 5864-8 (2009)
Article DOI: 10.1016/j.bmcl.2009.08.074
BindingDB Entry DOI: 10.7270/Q27944SC |
More data for this
Ligand-Target Pair | |
Bifunctional epoxide hydrolase 2
(Rattus norvegicus) | BDBM50302462
(CHEMBL566648 | N-(4-bromo-2-(trifluoromethoxy)benz...)Show SMILES FC(F)(F)CCOc1ccc(cn1)C(=O)NCc1ccc(Br)cc1OC(F)(F)F Show InChI InChI=1S/C17H13BrF6N2O3/c18-12-3-1-10(13(7-12)29-17(22,23)24)8-26-15(27)11-2-4-14(25-9-11)28-6-5-16(19,20)21/h1-4,7,9H,5-6,8H2,(H,26,27) | PDB
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| n/a | n/a | 7 | n/a | n/a | n/a | n/a | n/a | n/a |
Boehringer Ingelheim Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of rat sEH |
Bioorg Med Chem Lett 19: 5864-8 (2009)
Article DOI: 10.1016/j.bmcl.2009.08.074
BindingDB Entry DOI: 10.7270/Q27944SC |
More data for this
Ligand-Target Pair | |
Bifunctional epoxide hydrolase 2
(Rattus norvegicus) | BDBM50302474
(CHEMBL572205 | N-(2,4-dichlorobenzyl)-6-(2,2,2-tri...)Show InChI InChI=1S/C15H11Cl2F3N2O2/c16-11-3-1-9(12(17)5-11)6-22-14(23)10-2-4-13(21-7-10)24-8-15(18,19)20/h1-5,7H,6,8H2,(H,22,23) | PDB
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| n/a | n/a | 7.30 | n/a | n/a | n/a | n/a | n/a | n/a |
Boehringer Ingelheim Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of rat sEH |
Bioorg Med Chem Lett 19: 5864-8 (2009)
Article DOI: 10.1016/j.bmcl.2009.08.074
BindingDB Entry DOI: 10.7270/Q27944SC |
More data for this
Ligand-Target Pair | |
Bifunctional epoxide hydrolase 2
(Rattus norvegicus) | BDBM50302473
(CHEMBL565628 | N-(3,3-diphenylpropyl)-6-(2,2,2-tri...)Show SMILES FC(F)(F)COc1ccc(cn1)C(=O)NCCC(c1ccccc1)c1ccccc1 Show InChI InChI=1S/C23H21F3N2O2/c24-23(25,26)16-30-21-12-11-19(15-28-21)22(29)27-14-13-20(17-7-3-1-4-8-17)18-9-5-2-6-10-18/h1-12,15,20H,13-14,16H2,(H,27,29) | PDB
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| n/a | n/a | 7.80 | n/a | n/a | n/a | n/a | n/a | n/a |
Boehringer Ingelheim Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of rat sEH |
Bioorg Med Chem Lett 19: 5864-8 (2009)
Article DOI: 10.1016/j.bmcl.2009.08.074
BindingDB Entry DOI: 10.7270/Q27944SC |
More data for this
Ligand-Target Pair | |
Bifunctional epoxide hydrolase 2
(Rattus norvegicus) | BDBM50302463
(CHEMBL567314 | N-(2-chloro-4-cyanobenzyl)-6-(3,3,3...)Show SMILES FC(F)(F)CCOc1ccc(cn1)C(=O)NCc1ccc(cc1Cl)C#N Show InChI InChI=1S/C17H13ClF3N3O2/c18-14-7-11(8-22)1-2-12(14)9-24-16(25)13-3-4-15(23-10-13)26-6-5-17(19,20)21/h1-4,7,10H,5-6,9H2,(H,24,25) | PDB
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Boehringer Ingelheim Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of rat sEH |
Bioorg Med Chem Lett 19: 5864-8 (2009)
Article DOI: 10.1016/j.bmcl.2009.08.074
BindingDB Entry DOI: 10.7270/Q27944SC |
More data for this
Ligand-Target Pair | |
Bifunctional epoxide hydrolase 2
(Homo sapiens (Human)) | BDBM50302481
(CHEMBL567503 | N-(3,3-diphenylpropyl)-6-oxo-1,6-di...)Show InChI InChI=1S/C21H20N2O2/c24-20-12-11-18(15-23-20)21(25)22-14-13-19(16-7-3-1-4-8-16)17-9-5-2-6-10-17/h1-12,15,19H,13-14H2,(H,22,25)(H,23,24) | PDB
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| n/a | n/a | 8.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Boehringer Ingelheim Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of human soluble EH |
Bioorg Med Chem Lett 19: 5864-8 (2009)
Article DOI: 10.1016/j.bmcl.2009.08.074
BindingDB Entry DOI: 10.7270/Q27944SC |
More data for this
Ligand-Target Pair | |
Bifunctional epoxide hydrolase 2
(Rattus norvegicus) | BDBM50302479
(6-amino-N-(3,3-diphenylpropyl)nicotinamide | CHEMB...)Show InChI InChI=1S/C21H21N3O/c22-20-12-11-18(15-24-20)21(25)23-14-13-19(16-7-3-1-4-8-16)17-9-5-2-6-10-17/h1-12,15,19H,13-14H2,(H2,22,24)(H,23,25) | PDB
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| n/a | n/a | 8.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Boehringer Ingelheim Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of rat sEH |
Bioorg Med Chem Lett 19: 5864-8 (2009)
Article DOI: 10.1016/j.bmcl.2009.08.074
BindingDB Entry DOI: 10.7270/Q27944SC |
More data for this
Ligand-Target Pair | |
Bifunctional epoxide hydrolase 2
(Rattus norvegicus) | BDBM50302477
(CHEMBL566038 | N-(3,3-diphenylpropyl)-6-(2-(pyrrol...)Show SMILES O=C(NCCC(c1ccccc1)c1ccccc1)c1ccc(CCN2CCCC2)nc1 Show InChI InChI=1S/C27H31N3O/c31-27(24-13-14-25(29-21-24)16-20-30-18-7-8-19-30)28-17-15-26(22-9-3-1-4-10-22)23-11-5-2-6-12-23/h1-6,9-14,21,26H,7-8,15-20H2,(H,28,31) | PDB
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Boehringer Ingelheim Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of rat sEH |
Bioorg Med Chem Lett 19: 5864-8 (2009)
Article DOI: 10.1016/j.bmcl.2009.08.074
BindingDB Entry DOI: 10.7270/Q27944SC |
More data for this
Ligand-Target Pair | |
Bifunctional epoxide hydrolase 2
(Homo sapiens (Human)) | BDBM50302479
(6-amino-N-(3,3-diphenylpropyl)nicotinamide | CHEMB...)Show InChI InChI=1S/C21H21N3O/c22-20-12-11-18(15-24-20)21(25)23-14-13-19(16-7-3-1-4-8-16)17-9-5-2-6-10-17/h1-12,15,19H,13-14H2,(H2,22,24)(H,23,25) | PDB
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Boehringer Ingelheim Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of human soluble EH |
Bioorg Med Chem Lett 19: 5864-8 (2009)
Article DOI: 10.1016/j.bmcl.2009.08.074
BindingDB Entry DOI: 10.7270/Q27944SC |
More data for this
Ligand-Target Pair | |
Bifunctional epoxide hydrolase 2
(Rattus norvegicus) | BDBM50302481
(CHEMBL567503 | N-(3,3-diphenylpropyl)-6-oxo-1,6-di...)Show InChI InChI=1S/C21H20N2O2/c24-20-12-11-18(15-23-20)21(25)22-14-13-19(16-7-3-1-4-8-16)17-9-5-2-6-10-17/h1-12,15,19H,13-14H2,(H,22,25)(H,23,24) | PDB
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Boehringer Ingelheim Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of rat sEH |
Bioorg Med Chem Lett 19: 5864-8 (2009)
Article DOI: 10.1016/j.bmcl.2009.08.074
BindingDB Entry DOI: 10.7270/Q27944SC |
More data for this
Ligand-Target Pair | |
Bifunctional epoxide hydrolase 2
(Rattus norvegicus) | BDBM50302468
(CHEMBL585949 | N-(4-chloro-2-(methylsulfonyl)benzy...)Show SMILES CS(=O)(=O)c1cc(Cl)ccc1CNC(=O)c1ccc(OCCC(F)(F)F)nc1 Show InChI InChI=1S/C17H16ClF3N2O4S/c1-28(25,26)14-8-13(18)4-2-11(14)9-23-16(24)12-3-5-15(22-10-12)27-7-6-17(19,20)21/h2-5,8,10H,6-7,9H2,1H3,(H,23,24) | PDB
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Boehringer Ingelheim Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of rat sEH |
Bioorg Med Chem Lett 19: 5864-8 (2009)
Article DOI: 10.1016/j.bmcl.2009.08.074
BindingDB Entry DOI: 10.7270/Q27944SC |
More data for this
Ligand-Target Pair | |
Bifunctional epoxide hydrolase 2
(Homo sapiens (Human)) | BDBM50302463
(CHEMBL567314 | N-(2-chloro-4-cyanobenzyl)-6-(3,3,3...)Show SMILES FC(F)(F)CCOc1ccc(cn1)C(=O)NCc1ccc(cc1Cl)C#N Show InChI InChI=1S/C17H13ClF3N3O2/c18-14-7-11(8-22)1-2-12(14)9-24-16(25)13-3-4-15(23-10-13)26-6-5-17(19,20)21/h1-4,7,10H,5-6,9H2,(H,24,25) | PDB
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Boehringer Ingelheim Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of soluble EH in human HepG2 cells by cellular assay |
Bioorg Med Chem Lett 19: 5864-8 (2009)
Article DOI: 10.1016/j.bmcl.2009.08.074
BindingDB Entry DOI: 10.7270/Q27944SC |
More data for this
Ligand-Target Pair | |
Bifunctional epoxide hydrolase 2
(Homo sapiens (Human)) | BDBM50302461
(CHEMBL567703 | N-((4'-(methylsulfonyl)biphenyl-4-y...)Show SMILES CS(=O)(=O)c1ccc(cc1)-c1ccc(CNC(=O)c2ccc(OCCC(F)(F)F)nc2)cc1 Show InChI InChI=1S/C23H21F3N2O4S/c1-33(30,31)20-9-6-18(7-10-20)17-4-2-16(3-5-17)14-28-22(29)19-8-11-21(27-15-19)32-13-12-23(24,25)26/h2-11,15H,12-14H2,1H3,(H,28,29) | PDB
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Boehringer Ingelheim Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of human soluble EH |
Bioorg Med Chem Lett 19: 5864-8 (2009)
Article DOI: 10.1016/j.bmcl.2009.08.074
BindingDB Entry DOI: 10.7270/Q27944SC |
More data for this
Ligand-Target Pair | |
Bifunctional epoxide hydrolase 2
(Homo sapiens (Human)) | BDBM50302462
(CHEMBL566648 | N-(4-bromo-2-(trifluoromethoxy)benz...)Show SMILES FC(F)(F)CCOc1ccc(cn1)C(=O)NCc1ccc(Br)cc1OC(F)(F)F Show InChI InChI=1S/C17H13BrF6N2O3/c18-12-3-1-10(13(7-12)29-17(22,23)24)8-26-15(27)11-2-4-14(25-9-11)28-6-5-16(19,20)21/h1-4,7,9H,5-6,8H2,(H,26,27) | PDB
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| n/a | n/a | 12 | n/a | n/a | n/a | n/a | n/a | n/a |
Boehringer Ingelheim Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of human soluble EH |
Bioorg Med Chem Lett 19: 5864-8 (2009)
Article DOI: 10.1016/j.bmcl.2009.08.074
BindingDB Entry DOI: 10.7270/Q27944SC |
More data for this
Ligand-Target Pair | |
Bifunctional epoxide hydrolase 2
(Homo sapiens (Human)) | BDBM50302465
(CHEMBL566048 | N-(2-chloro-4-(N-methylsulfamoyl)be...)Show SMILES CNS(=O)(=O)c1ccc(CNC(=O)c2ccc(OCCC(F)(F)F)nc2)c(Cl)c1 Show InChI InChI=1S/C17H17ClF3N3O4S/c1-22-29(26,27)13-4-2-11(14(18)8-13)9-24-16(25)12-3-5-15(23-10-12)28-7-6-17(19,20)21/h2-5,8,10,22H,6-7,9H2,1H3,(H,24,25) | PDB
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| n/a | n/a | 14 | n/a | n/a | n/a | n/a | n/a | n/a |
Boehringer Ingelheim Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of human soluble EH |
Bioorg Med Chem Lett 19: 5864-8 (2009)
Article DOI: 10.1016/j.bmcl.2009.08.074
BindingDB Entry DOI: 10.7270/Q27944SC |
More data for this
Ligand-Target Pair | |
Bifunctional epoxide hydrolase 2
(Homo sapiens (Human)) | BDBM50302463
(CHEMBL567314 | N-(2-chloro-4-cyanobenzyl)-6-(3,3,3...)Show SMILES FC(F)(F)CCOc1ccc(cn1)C(=O)NCc1ccc(cc1Cl)C#N Show InChI InChI=1S/C17H13ClF3N3O2/c18-14-7-11(8-22)1-2-12(14)9-24-16(25)13-3-4-15(23-10-13)26-6-5-17(19,20)21/h1-4,7,10H,5-6,9H2,(H,24,25) | PDB
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| n/a | n/a | 14 | n/a | n/a | n/a | n/a | n/a | n/a |
Boehringer Ingelheim Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of human soluble EH |
Bioorg Med Chem Lett 19: 5864-8 (2009)
Article DOI: 10.1016/j.bmcl.2009.08.074
BindingDB Entry DOI: 10.7270/Q27944SC |
More data for this
Ligand-Target Pair | |
Bifunctional epoxide hydrolase 2
(Homo sapiens (Human)) | BDBM50302469
(CHEMBL568544 | N-(2-chloro-4-(methylsulfonyl)benzy...)Show SMILES CS(=O)(=O)c1ccc(CNC(=O)c2ccc(OCCC(F)(F)F)nc2)c(Cl)c1 Show InChI InChI=1S/C17H16ClF3N2O4S/c1-28(25,26)13-4-2-11(14(18)8-13)9-23-16(24)12-3-5-15(22-10-12)27-7-6-17(19,20)21/h2-5,8,10H,6-7,9H2,1H3,(H,23,24) | PDB
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| n/a | n/a | 15 | n/a | n/a | n/a | n/a | n/a | n/a |
Boehringer Ingelheim Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of human soluble EH |
Bioorg Med Chem Lett 19: 5864-8 (2009)
Article DOI: 10.1016/j.bmcl.2009.08.074
BindingDB Entry DOI: 10.7270/Q27944SC |
More data for this
Ligand-Target Pair | |
Bifunctional epoxide hydrolase 2
(Rattus norvegicus) | BDBM50302469
(CHEMBL568544 | N-(2-chloro-4-(methylsulfonyl)benzy...)Show SMILES CS(=O)(=O)c1ccc(CNC(=O)c2ccc(OCCC(F)(F)F)nc2)c(Cl)c1 Show InChI InChI=1S/C17H16ClF3N2O4S/c1-28(25,26)13-4-2-11(14(18)8-13)9-23-16(24)12-3-5-15(22-10-12)27-7-6-17(19,20)21/h2-5,8,10H,6-7,9H2,1H3,(H,23,24) | PDB
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| n/a | n/a | 16 | n/a | n/a | n/a | n/a | n/a | n/a |
Boehringer Ingelheim Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of rat sEH |
Bioorg Med Chem Lett 19: 5864-8 (2009)
Article DOI: 10.1016/j.bmcl.2009.08.074
BindingDB Entry DOI: 10.7270/Q27944SC |
More data for this
Ligand-Target Pair | |
Bifunctional epoxide hydrolase 2
(Homo sapiens (Human)) | BDBM50302476
(CHEMBL567283 | N-(2,4-dichlorobenzyl)-1-(2-ethoxye...)Show InChI InChI=1S/C17H18Cl2N2O3/c1-2-24-8-7-21-11-13(4-6-16(21)22)17(23)20-10-12-3-5-14(18)9-15(12)19/h3-6,9,11H,2,7-8,10H2,1H3,(H,20,23) | PDB
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Boehringer Ingelheim Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of human soluble EH |
Bioorg Med Chem Lett 19: 5864-8 (2009)
Article DOI: 10.1016/j.bmcl.2009.08.074
BindingDB Entry DOI: 10.7270/Q27944SC |
More data for this
Ligand-Target Pair | |
Bifunctional epoxide hydrolase 2
(Homo sapiens (Human)) | BDBM50302477
(CHEMBL566038 | N-(3,3-diphenylpropyl)-6-(2-(pyrrol...)Show SMILES O=C(NCCC(c1ccccc1)c1ccccc1)c1ccc(CCN2CCCC2)nc1 Show InChI InChI=1S/C27H31N3O/c31-27(24-13-14-25(29-21-24)16-20-30-18-7-8-19-30)28-17-15-26(22-9-3-1-4-10-22)23-11-5-2-6-12-23/h1-6,9-14,21,26H,7-8,15-20H2,(H,28,31) | PDB
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Boehringer Ingelheim Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of human soluble EH |
Bioorg Med Chem Lett 19: 5864-8 (2009)
Article DOI: 10.1016/j.bmcl.2009.08.074
BindingDB Entry DOI: 10.7270/Q27944SC |
More data for this
Ligand-Target Pair | |
Bifunctional epoxide hydrolase 2
(Homo sapiens (Human)) | BDBM50302474
(CHEMBL572205 | N-(2,4-dichlorobenzyl)-6-(2,2,2-tri...)Show InChI InChI=1S/C15H11Cl2F3N2O2/c16-11-3-1-9(12(17)5-11)6-22-14(23)10-2-4-13(21-7-10)24-8-15(18,19)20/h1-5,7H,6,8H2,(H,22,23) | PDB
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| n/a | n/a | 18 | n/a | n/a | n/a | n/a | n/a | n/a |
Boehringer Ingelheim Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of soluble EH in human HepG2 cells by cellular assay |
Bioorg Med Chem Lett 19: 5864-8 (2009)
Article DOI: 10.1016/j.bmcl.2009.08.074
BindingDB Entry DOI: 10.7270/Q27944SC |
More data for this
Ligand-Target Pair | |
Bifunctional epoxide hydrolase 2
(Rattus norvegicus) | BDBM50302465
(CHEMBL566048 | N-(2-chloro-4-(N-methylsulfamoyl)be...)Show SMILES CNS(=O)(=O)c1ccc(CNC(=O)c2ccc(OCCC(F)(F)F)nc2)c(Cl)c1 Show InChI InChI=1S/C17H17ClF3N3O4S/c1-22-29(26,27)13-4-2-11(14(18)8-13)9-24-16(25)12-3-5-15(23-10-12)28-7-6-17(19,20)21/h2-5,8,10,22H,6-7,9H2,1H3,(H,24,25) | PDB
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Boehringer Ingelheim Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of rat sEH |
Bioorg Med Chem Lett 19: 5864-8 (2009)
Article DOI: 10.1016/j.bmcl.2009.08.074
BindingDB Entry DOI: 10.7270/Q27944SC |
More data for this
Ligand-Target Pair | |
Bifunctional epoxide hydrolase 2
(Homo sapiens (Human)) | BDBM50302460
(CHEMBL567294 | N-(2-chloro-4-(1H-tetrazol-1-yl)ben...)Show SMILES FC(F)(F)CCOc1ccc(cn1)C(=O)NCc1ccc(cc1Cl)-n1cnnn1 Show InChI InChI=1S/C17H14ClF3N6O2/c18-14-7-13(27-10-24-25-26-27)3-1-11(14)8-23-16(28)12-2-4-15(22-9-12)29-6-5-17(19,20)21/h1-4,7,9-10H,5-6,8H2,(H,23,28) | PDB
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Boehringer Ingelheim Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of human soluble EH |
Bioorg Med Chem Lett 19: 5864-8 (2009)
Article DOI: 10.1016/j.bmcl.2009.08.074
BindingDB Entry DOI: 10.7270/Q27944SC |
More data for this
Ligand-Target Pair | |
Bifunctional epoxide hydrolase 2
(Homo sapiens (Human)) | BDBM50302464
(CHEMBL567110 | N-(2-(trifluoromethoxy)benzyl)-6-(3...)Show SMILES FC(F)(F)CCOc1ccc(cn1)C(=O)NCc1ccccc1OC(F)(F)F Show InChI InChI=1S/C17H14F6N2O3/c18-16(19,20)7-8-27-14-6-5-12(10-24-14)15(26)25-9-11-3-1-2-4-13(11)28-17(21,22)23/h1-6,10H,7-9H2,(H,25,26) | PDB
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Boehringer Ingelheim Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of soluble EH in human HepG2 cells by cellular assay |
Bioorg Med Chem Lett 19: 5864-8 (2009)
Article DOI: 10.1016/j.bmcl.2009.08.074
BindingDB Entry DOI: 10.7270/Q27944SC |
More data for this
Ligand-Target Pair | |
Bifunctional epoxide hydrolase 2
(Homo sapiens (Human)) | BDBM50302472
(CHEMBL572206 | N-(2-chlorobenzyl)-6-(3,3,3-trifluo...)Show InChI InChI=1S/C16H14ClF3N2O2/c17-13-4-2-1-3-11(13)9-22-15(23)12-5-6-14(21-10-12)24-8-7-16(18,19)20/h1-6,10H,7-9H2,(H,22,23) | PDB
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Boehringer Ingelheim Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of human soluble EH |
Bioorg Med Chem Lett 19: 5864-8 (2009)
Article DOI: 10.1016/j.bmcl.2009.08.074
BindingDB Entry DOI: 10.7270/Q27944SC |
More data for this
Ligand-Target Pair | |
Bifunctional epoxide hydrolase 2
(Rattus norvegicus) | BDBM50302472
(CHEMBL572206 | N-(2-chlorobenzyl)-6-(3,3,3-trifluo...)Show InChI InChI=1S/C16H14ClF3N2O2/c17-13-4-2-1-3-11(13)9-22-15(23)12-5-6-14(21-10-12)24-8-7-16(18,19)20/h1-6,10H,7-9H2,(H,22,23) | PDB
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Boehringer Ingelheim Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of rat sEH |
Bioorg Med Chem Lett 19: 5864-8 (2009)
Article DOI: 10.1016/j.bmcl.2009.08.074
BindingDB Entry DOI: 10.7270/Q27944SC |
More data for this
Ligand-Target Pair | |
Bifunctional epoxide hydrolase 2
(Homo sapiens (Human)) | BDBM50302461
(CHEMBL567703 | N-((4'-(methylsulfonyl)biphenyl-4-y...)Show SMILES CS(=O)(=O)c1ccc(cc1)-c1ccc(CNC(=O)c2ccc(OCCC(F)(F)F)nc2)cc1 Show InChI InChI=1S/C23H21F3N2O4S/c1-33(30,31)20-9-6-18(7-10-20)17-4-2-16(3-5-17)14-28-22(29)19-8-11-21(27-15-19)32-13-12-23(24,25)26/h2-11,15H,12-14H2,1H3,(H,28,29) | PDB
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| n/a | n/a | 24 | n/a | n/a | n/a | n/a | n/a | n/a |
Boehringer Ingelheim Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of soluble EH in human HepG2 cells by cellular assay |
Bioorg Med Chem Lett 19: 5864-8 (2009)
Article DOI: 10.1016/j.bmcl.2009.08.074
BindingDB Entry DOI: 10.7270/Q27944SC |
More data for this
Ligand-Target Pair | |
Bifunctional epoxide hydrolase 2
(Rattus norvegicus) | BDBM50302467
(CHEMBL566658 | N-(4-(methylsulfonyl)benzyl)-6-(3,3...)Show SMILES CS(=O)(=O)c1ccc(CNC(=O)c2ccc(OCCC(F)(F)F)nc2)cc1 Show InChI InChI=1S/C17H17F3N2O4S/c1-27(24,25)14-5-2-12(3-6-14)10-22-16(23)13-4-7-15(21-11-13)26-9-8-17(18,19)20/h2-7,11H,8-10H2,1H3,(H,22,23) | PDB
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Boehringer Ingelheim Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of rat sEH |
Bioorg Med Chem Lett 19: 5864-8 (2009)
Article DOI: 10.1016/j.bmcl.2009.08.074
BindingDB Entry DOI: 10.7270/Q27944SC |
More data for this
Ligand-Target Pair | |
Bifunctional epoxide hydrolase 2
(Homo sapiens (Human)) | BDBM50302469
(CHEMBL568544 | N-(2-chloro-4-(methylsulfonyl)benzy...)Show SMILES CS(=O)(=O)c1ccc(CNC(=O)c2ccc(OCCC(F)(F)F)nc2)c(Cl)c1 Show InChI InChI=1S/C17H16ClF3N2O4S/c1-28(25,26)13-4-2-11(14(18)8-13)9-23-16(24)12-3-5-15(22-10-12)27-7-6-17(19,20)21/h2-5,8,10H,6-7,9H2,1H3,(H,23,24) | PDB
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Boehringer Ingelheim Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of soluble EH in human HepG2 cells by cellular assay |
Bioorg Med Chem Lett 19: 5864-8 (2009)
Article DOI: 10.1016/j.bmcl.2009.08.074
BindingDB Entry DOI: 10.7270/Q27944SC |
More data for this
Ligand-Target Pair | |
Bifunctional epoxide hydrolase 2
(Homo sapiens (Human)) | BDBM50302465
(CHEMBL566048 | N-(2-chloro-4-(N-methylsulfamoyl)be...)Show SMILES CNS(=O)(=O)c1ccc(CNC(=O)c2ccc(OCCC(F)(F)F)nc2)c(Cl)c1 Show InChI InChI=1S/C17H17ClF3N3O4S/c1-22-29(26,27)13-4-2-11(14(18)8-13)9-24-16(25)12-3-5-15(23-10-12)28-7-6-17(19,20)21/h2-5,8,10,22H,6-7,9H2,1H3,(H,24,25) | PDB
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Boehringer Ingelheim Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of soluble EH in human HepG2 cells by cellular assay |
Bioorg Med Chem Lett 19: 5864-8 (2009)
Article DOI: 10.1016/j.bmcl.2009.08.074
BindingDB Entry DOI: 10.7270/Q27944SC |
More data for this
Ligand-Target Pair | |
Bifunctional epoxide hydrolase 2
(Homo sapiens (Human)) | BDBM50302460
(CHEMBL567294 | N-(2-chloro-4-(1H-tetrazol-1-yl)ben...)Show SMILES FC(F)(F)CCOc1ccc(cn1)C(=O)NCc1ccc(cc1Cl)-n1cnnn1 Show InChI InChI=1S/C17H14ClF3N6O2/c18-14-7-13(27-10-24-25-26-27)3-1-11(14)8-23-16(28)12-2-4-15(22-9-12)29-6-5-17(19,20)21/h1-4,7,9-10H,5-6,8H2,(H,23,28) | PDB
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| n/a | n/a | 38 | n/a | n/a | n/a | n/a | n/a | n/a |
Boehringer Ingelheim Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of soluble EH in human HepG2 cells by cellular assay |
Bioorg Med Chem Lett 19: 5864-8 (2009)
Article DOI: 10.1016/j.bmcl.2009.08.074
BindingDB Entry DOI: 10.7270/Q27944SC |
More data for this
Ligand-Target Pair | |
Bifunctional epoxide hydrolase 2
(Rattus norvegicus) | BDBM50302470
(CHEMBL576449 | N-benzyl-6-(3,3,3-trifluoropropoxy)...)Show InChI InChI=1S/C16H15F3N2O2/c17-16(18,19)8-9-23-14-7-6-13(11-20-14)15(22)21-10-12-4-2-1-3-5-12/h1-7,11H,8-10H2,(H,21,22) | PDB
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| n/a | n/a | 50 | n/a | n/a | n/a | n/a | n/a | n/a |
Boehringer Ingelheim Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of rat sEH |
Bioorg Med Chem Lett 19: 5864-8 (2009)
Article DOI: 10.1016/j.bmcl.2009.08.074
BindingDB Entry DOI: 10.7270/Q27944SC |
More data for this
Ligand-Target Pair | |
Bifunctional epoxide hydrolase 2
(Homo sapiens (Human)) | BDBM50302468
(CHEMBL585949 | N-(4-chloro-2-(methylsulfonyl)benzy...)Show SMILES CS(=O)(=O)c1cc(Cl)ccc1CNC(=O)c1ccc(OCCC(F)(F)F)nc1 Show InChI InChI=1S/C17H16ClF3N2O4S/c1-28(25,26)14-8-13(18)4-2-11(14)9-23-16(24)12-3-5-15(22-10-12)27-7-6-17(19,20)21/h2-5,8,10H,6-7,9H2,1H3,(H,23,24) | PDB
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| n/a | n/a | 66 | n/a | n/a | n/a | n/a | n/a | n/a |
Boehringer Ingelheim Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of human soluble EH |
Bioorg Med Chem Lett 19: 5864-8 (2009)
Article DOI: 10.1016/j.bmcl.2009.08.074
BindingDB Entry DOI: 10.7270/Q27944SC |
More data for this
Ligand-Target Pair | |
Bifunctional epoxide hydrolase 2
(Homo sapiens (Human)) | BDBM50302471
(CHEMBL565841 | N-(4-chlorobenzyl)-6-(3,3,3-trifluo...)Show InChI InChI=1S/C16H14ClF3N2O2/c17-13-4-1-11(2-5-13)9-22-15(23)12-3-6-14(21-10-12)24-8-7-16(18,19)20/h1-6,10H,7-9H2,(H,22,23) | PDB
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| n/a | n/a | 77 | n/a | n/a | n/a | n/a | n/a | n/a |
Boehringer Ingelheim Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of human soluble EH |
Bioorg Med Chem Lett 19: 5864-8 (2009)
Article DOI: 10.1016/j.bmcl.2009.08.074
BindingDB Entry DOI: 10.7270/Q27944SC |
More data for this
Ligand-Target Pair | |
Bifunctional epoxide hydrolase 2
(Homo sapiens (Human)) | BDBM50302467
(CHEMBL566658 | N-(4-(methylsulfonyl)benzyl)-6-(3,3...)Show SMILES CS(=O)(=O)c1ccc(CNC(=O)c2ccc(OCCC(F)(F)F)nc2)cc1 Show InChI InChI=1S/C17H17F3N2O4S/c1-27(24,25)14-5-2-12(3-6-14)10-22-16(23)13-4-7-15(21-11-13)26-9-8-17(18,19)20/h2-7,11H,8-10H2,1H3,(H,22,23) | PDB
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| n/a | n/a | 110 | n/a | n/a | n/a | n/a | n/a | n/a |
Boehringer Ingelheim Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of human soluble EH |
Bioorg Med Chem Lett 19: 5864-8 (2009)
Article DOI: 10.1016/j.bmcl.2009.08.074
BindingDB Entry DOI: 10.7270/Q27944SC |
More data for this
Ligand-Target Pair | |
Bifunctional epoxide hydrolase 2
(Rattus norvegicus) | BDBM50302466
(CHEMBL566047 | N-(2-(methylsulfonyl)benzyl)-6-(3,3...)Show SMILES CS(=O)(=O)c1ccccc1CNC(=O)c1ccc(OCCC(F)(F)F)nc1 Show InChI InChI=1S/C17H17F3N2O4S/c1-27(24,25)14-5-3-2-4-12(14)10-22-16(23)13-6-7-15(21-11-13)26-9-8-17(18,19)20/h2-7,11H,8-10H2,1H3,(H,22,23) | PDB
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Boehringer Ingelheim Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of rat sEH |
Bioorg Med Chem Lett 19: 5864-8 (2009)
Article DOI: 10.1016/j.bmcl.2009.08.074
BindingDB Entry DOI: 10.7270/Q27944SC |
More data for this
Ligand-Target Pair | |
Bifunctional epoxide hydrolase 2
(Homo sapiens (Human)) | BDBM50302483
(CHEMBL565629 | N1-(2,4-dichlorobenzyl)-N4-(tetrahy...)Show SMILES Clc1ccc(CNC(=O)N2CCC(CC2)C(=O)NC2CCOCC2)c(Cl)c1 Show InChI InChI=1S/C19H25Cl2N3O3/c20-15-2-1-14(17(21)11-15)12-22-19(26)24-7-3-13(4-8-24)18(25)23-16-5-9-27-10-6-16/h1-2,11,13,16H,3-10,12H2,(H,22,26)(H,23,25) | PDB
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| n/a | n/a | 180 | n/a | n/a | n/a | n/a | n/a | n/a |
Boehringer Ingelheim Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of human soluble EH |
Bioorg Med Chem Lett 19: 5864-8 (2009)
Article DOI: 10.1016/j.bmcl.2009.08.074
BindingDB Entry DOI: 10.7270/Q27944SC |
More data for this
Ligand-Target Pair | |
Bifunctional epoxide hydrolase 2
(Rattus norvegicus) | BDBM50302460
(CHEMBL567294 | N-(2-chloro-4-(1H-tetrazol-1-yl)ben...)Show SMILES FC(F)(F)CCOc1ccc(cn1)C(=O)NCc1ccc(cc1Cl)-n1cnnn1 Show InChI InChI=1S/C17H14ClF3N6O2/c18-14-7-13(27-10-24-25-26-27)3-1-11(14)8-23-16(28)12-2-4-15(22-9-12)29-6-5-17(19,20)21/h1-4,7,9-10H,5-6,8H2,(H,23,28) | PDB
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| n/a | n/a | 180 | n/a | n/a | n/a | n/a | n/a | n/a |
Boehringer Ingelheim Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of rat sEH |
Bioorg Med Chem Lett 19: 5864-8 (2009)
Article DOI: 10.1016/j.bmcl.2009.08.074
BindingDB Entry DOI: 10.7270/Q27944SC |
More data for this
Ligand-Target Pair | |
Bifunctional epoxide hydrolase 2
(Homo sapiens (Human)) | BDBM50302466
(CHEMBL566047 | N-(2-(methylsulfonyl)benzyl)-6-(3,3...)Show SMILES CS(=O)(=O)c1ccccc1CNC(=O)c1ccc(OCCC(F)(F)F)nc1 Show InChI InChI=1S/C17H17F3N2O4S/c1-27(24,25)14-5-3-2-4-12(14)10-22-16(23)13-6-7-15(21-11-13)26-9-8-17(18,19)20/h2-7,11H,8-10H2,1H3,(H,22,23) | PDB
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| n/a | n/a | 270 | n/a | n/a | n/a | n/a | n/a | n/a |
Boehringer Ingelheim Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of human soluble EH |
Bioorg Med Chem Lett 19: 5864-8 (2009)
Article DOI: 10.1016/j.bmcl.2009.08.074
BindingDB Entry DOI: 10.7270/Q27944SC |
More data for this
Ligand-Target Pair | |
Bifunctional epoxide hydrolase 2
(Rattus norvegicus) | BDBM50302482
(CHEMBL568770 | N-(2,4-dichlorobenzyl)-6-oxo-1,6-di...)Show InChI InChI=1S/C13H10Cl2N2O2/c14-10-3-1-8(11(15)5-10)6-17-13(19)9-2-4-12(18)16-7-9/h1-5,7H,6H2,(H,16,18)(H,17,19) | PDB
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Boehringer Ingelheim Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of rat sEH |
Bioorg Med Chem Lett 19: 5864-8 (2009)
Article DOI: 10.1016/j.bmcl.2009.08.074
BindingDB Entry DOI: 10.7270/Q27944SC |
More data for this
Ligand-Target Pair | |
Bifunctional epoxide hydrolase 2
(Homo sapiens (Human)) | BDBM50302482
(CHEMBL568770 | N-(2,4-dichlorobenzyl)-6-oxo-1,6-di...)Show InChI InChI=1S/C13H10Cl2N2O2/c14-10-3-1-8(11(15)5-10)6-17-13(19)9-2-4-12(18)16-7-9/h1-5,7H,6H2,(H,16,18)(H,17,19) | PDB
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| n/a | n/a | 400 | n/a | n/a | n/a | n/a | n/a | n/a |
Boehringer Ingelheim Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of human soluble EH |
Bioorg Med Chem Lett 19: 5864-8 (2009)
Article DOI: 10.1016/j.bmcl.2009.08.074
BindingDB Entry DOI: 10.7270/Q27944SC |
More data for this
Ligand-Target Pair | |
Bifunctional epoxide hydrolase 2
(Rattus norvegicus) | BDBM50302480
(6-amino-N-(2,4-dichlorobenzyl)nicotinamide | CHEMB...)Show InChI InChI=1S/C13H11Cl2N3O/c14-10-3-1-8(11(15)5-10)6-18-13(19)9-2-4-12(16)17-7-9/h1-5,7H,6H2,(H2,16,17)(H,18,19) | PDB
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Boehringer Ingelheim Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of rat sEH |
Bioorg Med Chem Lett 19: 5864-8 (2009)
Article DOI: 10.1016/j.bmcl.2009.08.074
BindingDB Entry DOI: 10.7270/Q27944SC |
More data for this
Ligand-Target Pair | |
Bifunctional epoxide hydrolase 2
(Rattus norvegicus) | BDBM50302478
(CHEMBL568342 | N-(2,4-dichlorobenzyl)-6-(2-(pyrrol...)Show InChI InChI=1S/C19H21Cl2N3O/c20-16-5-3-14(18(21)11-16)12-23-19(25)15-4-6-17(22-13-15)7-10-24-8-1-2-9-24/h3-6,11,13H,1-2,7-10,12H2,(H,23,25) | PDB
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Boehringer Ingelheim Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of rat sEH |
Bioorg Med Chem Lett 19: 5864-8 (2009)
Article DOI: 10.1016/j.bmcl.2009.08.074
BindingDB Entry DOI: 10.7270/Q27944SC |
More data for this
Ligand-Target Pair | |
Bifunctional epoxide hydrolase 2
(Homo sapiens (Human)) | BDBM50302480
(6-amino-N-(2,4-dichlorobenzyl)nicotinamide | CHEMB...)Show InChI InChI=1S/C13H11Cl2N3O/c14-10-3-1-8(11(15)5-10)6-18-13(19)9-2-4-12(16)17-7-9/h1-5,7H,6H2,(H2,16,17)(H,18,19) | PDB
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| n/a | n/a | 520 | n/a | n/a | n/a | n/a | n/a | n/a |
Boehringer Ingelheim Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of human soluble EH |
Bioorg Med Chem Lett 19: 5864-8 (2009)
Article DOI: 10.1016/j.bmcl.2009.08.074
BindingDB Entry DOI: 10.7270/Q27944SC |
More data for this
Ligand-Target Pair | |
Bifunctional epoxide hydrolase 2
(Homo sapiens (Human)) | BDBM50302470
(CHEMBL576449 | N-benzyl-6-(3,3,3-trifluoropropoxy)...)Show InChI InChI=1S/C16H15F3N2O2/c17-16(18,19)8-9-23-14-7-6-13(11-20-14)15(22)21-10-12-4-2-1-3-5-12/h1-7,11H,8-10H2,(H,21,22) | PDB
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| n/a | n/a | 1.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Boehringer Ingelheim Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of human soluble EH |
Bioorg Med Chem Lett 19: 5864-8 (2009)
Article DOI: 10.1016/j.bmcl.2009.08.074
BindingDB Entry DOI: 10.7270/Q27944SC |
More data for this
Ligand-Target Pair | |
Bifunctional epoxide hydrolase 2
(Homo sapiens (Human)) | BDBM50302478
(CHEMBL568342 | N-(2,4-dichlorobenzyl)-6-(2-(pyrrol...)Show InChI InChI=1S/C19H21Cl2N3O/c20-16-5-3-14(18(21)11-16)12-23-19(25)15-4-6-17(22-13-15)7-10-24-8-1-2-9-24/h3-6,11,13H,1-2,7-10,12H2,(H,23,25) | PDB
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| n/a | n/a | 1.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Boehringer Ingelheim Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of human soluble EH |
Bioorg Med Chem Lett 19: 5864-8 (2009)
Article DOI: 10.1016/j.bmcl.2009.08.074
BindingDB Entry DOI: 10.7270/Q27944SC |
More data for this
Ligand-Target Pair | |
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