The following articles (labelled with PubMed ID or TBD) are for your review
PMID | Data | Article Title | Organization |
27690432 |
75 |
Discovery of Second Generation Reversible Covalent DPP1 Inhibitors Leading to an Oxazepane Amidoacetonitrile Based Clinical Candidate (AZD7986). |
Charles River Discovery Research Services |
25571794 |
40 |
Structure-based design and optimization of potent inhibitors of the adenoviral protease. |
Novartis Institute For Biomedical Research |
24592859 |
59 |
Cathepsin C inhibitors: property optimization and identification of a clinical candidate. |
Astrazeneca |
24900293 |
78 |
Discovery of novel cyanamide-based inhibitors of cathepsin C. |
TBA |
19715320 |
87 |
Grassystatins A-C from marine cyanobacteria, potent cathepsin E inhibitors that reduce antigen presentation. |
University of Florida |
17535802 |
91 |
Inhibition of the activation of multiple serine proteases with a cathepsin C inhibitor requires sustained exposure to prevent pro-enzyme processing. |
Merck Research Laboratories |
18226527 |
80 |
The discovery of odanacatib (MK-0822), a selective inhibitor of cathepsin K. |
Merck Frosst Centre For Therapeutic Research |
19665376 |
48 |
Design and synthesis of dipeptidyl nitriles as potent, selective, and reversible inhibitors of cathepsin C. |
Merck Frosst Canada |
19908842 |
84 |
Identification and optimization of inhibitors of Trypanosomal cysteine proteases: cruzain, rhodesain, and TbCatB. |
National Human Genome Research Institute |
18313933 |
18 |
Substrate optimization for monitoring cathepsin C activity in live cells. |
Genomics Institute of The Novartis Research Foundation |
17196818 |
90 |
Bicyclic carbamates as inhibitors of papain-like cathepsin proteases. |
The Genomics Institute of The Novartis Research Foundation |
16647256 |
16 |
Dipeptidyl nitriles as human dipeptidyl peptidase I inhibitors. |
Arpida |
31145622 |
91 |
Identification and Optimization of Novel Cathepsin C Inhibitors Derived from EGFR Inhibitors. |
National Institute of Biological Sciences (Nibs) |
31413809 |
8 |
DPP1 Inhibitors: Exploring the Role of Water in the S2 Pocket of DPP1 with Substituted Pyrrolidines. |
Astrazeneca |
3941405 |
15 |
Carboxyl-modified amino acids and peptides as protease inhibitors. |
TBA |
23356427 |
16 |
Synthesis and carbonic anhydrase inhibitory properties of 1,3-dicarbonyl derivatives of methylaminobenzene-sulfonamide. |
Sakarya University |
2894455 |
17 |
Characterization of alpha-2 adrenergic receptors in the OK cell, an opossum kidney cell line. |
University of Missouri |
15710600 |
29 |
Demonstration of isoleucine 199 as a structural determinant for the selective inhibition of human monoamine oxidase B by specific reversible inhibitors. |
Emory University |
15225699 |
27 |
Preparation of novel aza-1,7-annulated indoles and their conversion to potent indolocarbazole kinase inhibitors. |
Eli Lilly |
| 96 |
Novel Indolocarbazole protein kinase C inhibitors with improved biochemical and physicochemical properties. |
Tumor Biology Center |