The following articles (labelled with PubMed ID or TBD) are for your review
| PMID | Data | Article Title | Organization |
|---|
| 28359792 |
65 |
4-Anilino-pyrimidine, novel aldosterone synthase (CYP11B2) inhibitors bearing pyrimidine structures. |
Daiichi Sankyo |
| 27979595 |
73 |
Imidazopyridyl compounds as aldosterone synthase inhibitors. |
Merck Usa |
| 28105288 |
32 |
Discovery of Spirocyclic Aldosterone Synthase Inhibitors as Potential Treatments for Resistant Hypertension. |
Merck Research Laboratories |
| 26938274 |
52 |
Exploiting the Chromone Scaffold for the Development of Inhibitors of Corticosteroid Biosynthesis. |
University Of Bologna |
| 26403853 |
32 |
Discovery of 4-Aryl-5,6,7,8-tetrahydroisoquinolines as Potent, Selective, and Orally Active Aldosterone Synthase (CYP11B2) Inhibitors: In Vivo Evaluation in Rodents and Cynomolgus Monkeys. |
Roche Pharma Research And Early Development (Pred) |
| 26288685 |
59 |
Discovery of Triazole CYP11B2 Inhibitors with in Vivo Activity in Rhesus Monkeys. |
Merck Research Laboratories |
| 26005536 |
92 |
Discovery of Benzimidazole CYP11B2 Inhibitors with in Vivo Activity in Rhesus Monkeys. |
Merck Research Laboratories |
| 25874338 |
90 |
Identification of 4-(4-nitro-2-phenethoxyphenyl)pyridine as a promising new lead for discovering inhibitors of both human and rat 11ß-Hydroxylase. |
Saarland University |
| 25711516 |
118 |
Novel pyridyl substituted 4,5-dihydro-[1,2,4]triazolo[4,3-a]quinolines as potent and selective aldosterone synthase inhibitors with improved in vitro metabolic stability. |
Saarland University And Helmholtz Institute For Pharmaceutical Research Saarland (Hips) |
| 25528333 |
32 |
Heteroatom insertion into 3,4-dihydro-1H-quinolin-2-ones leads to potent and selective inhibitors of human and rat aldosterone synthase. |
Saarland University |
| 24422519 |
31 |
Aldosterone synthase inhibitors as promising treatments for mineralocorticoid dependent cardiovascular and renal diseases. |
Saarland University And Helmholtz Institute For Pharmaceutical Research Saarland (Hips) |
| 25462268 |
44 |
1-Phenylsulfinyl-3-(pyridin-3-yl)naphthalen-2-ols: a new class of potent and selective aldosterone synthase inhibitors. |
Saarland University And Helmholtz Institute For Pharmaceutical Research Saarland (Hips) |
| 25462231 |
85 |
Discovery of new 7-substituted-4-imidazolylmethyl coumarins and 4'-substituted-2-imidazolyl acetophenones open analogues as potent and selective inhibitors of steroid-11ß-hydroxylase. |
Universit£ |
| 25176013 |
70 |
Potent 11ß-hydroxylase inhibitors with inverse metabolic stability in human plasma and hepatic S9 fractions to promote wound healing. |
Saarland University And Helmholtz Institute For Pharmaceutical Research Saarland (Hips) |
| 24899257 |
71 |
Novel pyridyl- or isoquinolinyl-substituted indolines and indoles as potent and selective aldosterone synthase inhibitors. |
Saarland University |
| 24900631 |
50 |
Discovery and in Vivo Evaluation of Potent Dual CYP11B2 (Aldosterone Synthase) and CYP11B1 Inhibitors. |
Novartis Institutes For Biomedical Research |
| 23992859 |
2 |
Emerging technologies for metabolite generation and structural diversification. |
Abbvie Bioresearch Center |
| 23869452 |
67 |
Cushing's syndrome: development of highly potent and selective CYP11B1 inhibitors of the (pyridylmethyl)pyridine type. |
Saarland University |
| 23859149 |
76 |
Highly potent and selective nonsteroidal dual inhibitors of CYP17/CYP11B2 for the treatment of prostate cancer to reduce risks of cardiovascular diseases. |
Saarland University & Helmholtz Institute For Pharmaceutical Research Saarland (Hips) |
| 23363058 |
68 |
Modulation of cytochromes P450 with xanthone-based molecules: from aromatase to aldosterone synthase and steroid 11ß-hydroxylase inhibition. |
University Of Bologna |
| 24900680 |
18 |
Selective Cyp11B1 Inhibitors for the Treatment of Cortisol Dependent Diseases. |
Temple University |
| 24900679 |
16 |
Aldosterone synthase inhibitors. |
Temple University |
| 24900648 |
2 |
Aldosterone synthase inhibitors: targeting chronic kidney disease and diabetic nephropathy. |
Therachem Research Medilab (India) |
| 23281812 |
95 |
Tetrahydropyrroloquinolinone type dual inhibitors of aromatase/aldosterone synthase as a novel strategy for breast cancer patients with elevated cardiovascular risks. |
Saarland University & Helmholtz Institute For Pharmaceutical Research Saarland (Hips) |
| 22861193 |
60 |
Selective dual inhibitors of CYP19 and CYP11B2: targeting cardiovascular diseases hiding in the shadow of breast cancer. |
Saarland University & Helmholtz Institute For Pharmaceutical Research Saarland (Hips) |
| 22788843 |
46 |
Novel imidazol-1-ylmethyl substituted 1,2,5,6-tetrahydropyrrolo[3,2,1-ij]quinolin-4-ones as potent and selective CYP11B1 inhibitors for the treatment of Cushing's syndrome. |
Saarland University And Helmholtz Institute For Pharmaceutical Research Saarland (Hips) |
| 24900349 |
90 |
Optimization of the First Selective Steroid-11ß-hydroxylase (CYP11B1) Inhibitors for the Treatment of Cortisol Dependent Diseases. |
TBA |
| 20550118 |
69 |
Isopropylidene substitution increases activity and selectivity of biphenylmethylene 4-pyridine type CYP17 inhibitors. |
Saarland University |
| 21384875 |
67 |
Fine-tuning the selectivity of aldosterone synthase inhibitors: structure-activity and structure-selectivity insights from studies of heteroaryl substituted 1,2,5,6-tetrahydropyrrolo[3,2,1-ij]quinolin-4-one derivatives. |
Saarland University |
| 21341743 |
42 |
Design, synthesis, and biological evaluation of imidazolyl derivatives of 4,7-disubstituted coumarins as aromatase inhibitors selective over 17-a-hydroxylase/C17-20 lyase. |
Universita` Degli Studi Di Bari Aldo Moro |
| 24900247 |
78 |
First Selective CYP11B1 Inhibitors for the Treatment of Cortisol-Dependent Diseases |
TBA |
| 21129965 |
18 |
N-(Pyridin-3-yl)benzamides as selective inhibitors of human aldosterone synthase (CYP11B2). |
Saarland University & Helmholtz Institute For Pharmaceutical Research Saarland |
| 20684610 |
73 |
Replacement of imidazolyl by pyridyl in biphenylmethylenes results in selective CYP17 and dual CYP17/CYP11B1 inhibitors for the treatment of prostate cancer. |
Saarland University |
| 20615692 |
52 |
The discovery of potent inhibitors of aldosterone synthase that exhibit selectivity over 11-beta-hydroxylase. |
Novartis Institutes For Biomedical Research |
| 20121113 |
94 |
Synthesis, biological evaluation, and molecular modeling of 1-benzyl-1H-imidazoles as selective inhibitors of aldosterone synthase (CYP11B2). |
Eindhoven University Of Technology |
| 19049427 |
98 |
In vivo active aldosterone synthase inhibitors with improved selectivity: lead optimization providing a series of pyridine substituted 3,4-dihydro-1H-quinolin-2-one derivatives. |
Saarland University |
| 18763754 |
57 |
Novel aldosterone synthase inhibitors with extended carbocyclic skeleton by a combined ligand-based and structure-based drug design approach. |
Saarland University |
| 18672861 |
91 |
Overcoming undesirable CYP1A2 inhibition of pyridylnaphthalene-type aldosterone synthase inhibitors: influence of heteroaryl derivatization on potency and selectivity. |
Saarland University |
| 8632407 |
43 |
Tetrahydronaphthalenes: influence of heterocyclic substituents on inhibition of steroid enzymes P450 arom and P450 17. |
UniversitäT De Saarlandes |
| 28570067 |
63 |
Lead Optimization Generates CYP11B1 Inhibitors of Pyridylmethyl Isoxazole Type with Improved Pharmacological Profile for the Treatment of Cushing's Disease. |
Saarland University |
| 1848629 |
42 |
gamma-Aminobutyric acidA receptor heterogeneity in rat central nervous system: studies with clonazepam and other benzodiazepine ligands. |
Georgetown University |
| 19633659 |
3 |
Inhibition of a viral enzyme by a small-molecule dimer disruptor. |
University Of California San Francisco |
| 19136975 |
132 |
Design of isoform-selective phospholipase D inhibitors that modulate cancer cell invasiveness. |
Vanderbilt University |
| 18291646 |
33 |
Synthesis and SAR studies of indole-based MK2 inhibitors. |
Boehringer Ingelheim Pharmaceuticals |
| 17576063 |
69 |
The discovery of carboline analogs as potent MAPKAP-K2 inhibitors. |
Boehringer Ingelheim Pharmaceuticals |
| 18686942 |
20 |
Asymmetric synthesis of inhibitors of glycinamide ribonucleotide transformylase. |
The Scripps Research Institute |
| 15355974 |
6 |
Crystal structure of avian aminoimidazole-4-carboxamide ribonucleotide transformylase in complex with a novel non-folate inhibitor identified by virtual ligand screening. |
The Scripps Research Institute |
| 18433114 |
28 |
4-benzyl-1H-imidazoles with oxazoline termini as histamine H3 receptor agonists. |
Vu University Amsterdam |
| 18419108 |
37 |
2-Amino-1,3-thiazol-4(5H)-ones as Potent and Selective 11beta-Hydroxysteroid Dehydrogenase Type 1 Inhibitors: Enzyme-Ligand Co-Crystal Structure and Demonstration of Pharmacodynamic Effects in C57Bl/6 Mice. |
Biovitrum |
| 17274610 |
263 |
Indanylacetic acid derivatives carrying 4-thiazolyl-phenoxy tail groups, a new class of potent PPAR alpha/gamma/delta pan agonists: synthesis, structure-activity relationship, and in vivo efficacy. |
Bayer Healthcare Pharmaceuticals |
| 16446090 |
42 |
Synthesis and biological evaluation of 1-(2,4,5-trisubstituted phenyl)-3-(5-cyanopyrazin-2-yl)ureas as potent Chk1 kinase inhibitors. |
Abbott Laboratories |
| 15911281 |
30 |
Benzimidazolones and indoles as non-thiol farnesyltransferase inhibitors based on tipifarnib scaffold: synthesis and activity. |
Abbott Laboratories |
| 10779411 |
24 |
Structural basis for selectivity of a small molecule, S1-binding, submicromolar inhibitor of urokinase-type plasminogen activator. |
Axys Pharmaceutical |
| 16697194 |
22 |
Design and synthesis of orally active pyrrolidin-2-one-based factor Xa inhibitors. |
Glaxosmithkline |
| 16337122 |
11 |
SAR and inhibitor complex structure determination of a novel class of potent and specific Aurora kinase inhibitors. |
Astrazeneca |
| 16536518 |
11 |
Enthalpy versus entropy-driven binding of bisphosphonates to farnesyl diphosphate synthase. |
University Of Illinois At Urbana-Champaign |
| | 2 |
Thermodynamics of Binding of 2-Methoxy-3-isopropylpyrazine and 2-Methoxy-3-isobutylpyrazine to the Major Urinary Protein |
University Of Leeds |
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