The following articles (labelled with PubMed ID or TBD) are for your review
| PMID | Data | Article Title | Organization |
|---|
| 24900853 |
42 |
3-Amido-3-aryl-piperidines: A Novel Class of Potent, Selective, and Orally Active GlyT1 Inhibitors. |
F. Hoffmann-La Roche |
| 24462664 |
58 |
Novel GlyT1 inhibitor chemotypes by scaffold hopping. Part 2: development of a [3.3.0]-based series and other piperidine bioisosteres. |
Vanderbilt University Medical Center |
| 24461352 |
51 |
Novel GlyT1 inhibitor chemotypes by scaffold hopping. Part 1: development of a potent and CNS penetrant [3.1.0]-based lead. |
Vanderbilt University Medical Center |
| 24112084 |
6 |
The lignan (-)-hinokinin displays modulatory effects on human monoamine and GABA transporter activities. |
Drexel University College of Medicine |
| 23837744 |
50 |
Atropisomeric 4-phenyl-4H-1,2,4-triazoles as selective glycine transporter 1 inhibitors. |
Astellas Pharma |
| 23380375 |
48 |
Design, synthesis, and SAR of N-((1-(4-(propylsulfonyl)piperazin-1-yl)cycloalkyl)methyl)benzamide inhibitors of glycine transporter-1. |
Amri |
| 17234406 |
32 |
1,3-diaminopropan-2-ol sulfonamides as potent and selective inhibitors of the glycine transporter type 1. |
Glaxosmithkline |
| 21889344 |
66 |
Acylglycinamides as inhibitors of glycine transporter type 1. |
Glaxosmithkline |
| 11454468 |
35 |
Discovery and SAR of org 24598-a selective glycine uptake inhibitor. |
Organon Research and Development Group |
| 24900218 |
20 |
Identification of an Orally Bioavailable, Potent, and Selective Inhibitor of GlyT1. |
TBA |
| 20491477 |
91 |
Selective GlyT1 inhibitors: discovery of [4-(3-fluoro-5-trifluoromethylpyridin-2-yl)piperazin-1-yl][5-methanesulfonyl-2-((S)-2,2,2-trifluoro-1-methylethoxy)phenyl]methanone (RG1678), a promising novel medicine to treat schizophrenia. |
F. Hoffmann-La Roche |
| 16987662 |
74 |
Synthesis and SAR of GlyT1 inhibitors derived from a series of N-((4-(morpholine-4-carbonyl)-1-(propylsulfonyl)piperidin-4-yl)methyl)benzamides. |
Merck And |
| 16762550 |
101 |
4-Substituted-8-(1-phenyl-cyclohexyl)-2,8-diaza-spiro[4.5]decan-1-one as a novel class of highly selective GlyT1 inhibitors with superior pharmacological and pharmacokinetic parameters. |
F. Hoffmann-La Roche |
| 21975065 |
8 |
Synthesis and characterization of [¹²¿?¿I]2-iodo N-[(S)-{(S)-1-methylpiperidin-2-yl}(phenyl)methyl]3-trifluoromethyl-benzamide as novel imaging probe for glycine transporter 1. |
Nagasaki University |
| 20974532 |
57 |
Discovery of benzoylisoindolines as a novel class of potent, selective and orally active GlyT1 inhibitors. |
F. Hoffmann-La Roche |
| 20045321 |
85 |
An octahydro-cyclopenta[c]pyrrole series of inhibitors of the type 1 glycine transporter. |
Pfizer |
| 19410451 |
31 |
The discovery of a structurally novel class of inhibitors of the type 1 glycine transporter. |
Pfizer |
| 19318248 |
29 |
Optimisation of a series of potent, selective and orally bioavailable GlyT1 inhibitors. |
Merck Sharp and Dohme Research Laboratories |
| 19181525 |
35 |
Discovery of GlyT1 inhibitors with improved pharmacokinetic properties. |
Merck |
| 19179073 |
94 |
Discovery of N-{[1-(propylsulfonyl)-4-pyridin-2-ylpiperidin-4-yl]methyl}benzamides as novel, selective and potent GlyT1 inhibitors. |
Merck |
| 18805008 |
133 |
Design, synthesis and structure-activity relationship of simple bis-amides as potent inhibitors of GlyT1. |
F. Hoffmann-La Roche |
| 18752953 |
111 |
Discovery of benzoylpiperazines as a novel class of potent and selective GlyT1 inhibitors. |
F. Hoffmann-La Roche |
| 17629697 |
79 |
Discovery and SAR studies of novel GlyT1 inhibitors. |
Eli Lilly |
| 17257843 |
35 |
A novel, non-substrate-based series of glycine type 1 transporter inhibitors derived from high-throughput screening. |
Pfizer |
| 16762548 |
37 |
Design and synthesis of 4-substituted-8-(2-phenyl-cyclohexyl)-2,8-diaza-spiro[4.5]decan-1-one as a novel class of GlyT1 inhibitors: achieving selectivity against the mu opioid and nociceptin/orphanin FQ peptide (NOP) receptors. |
F. Hoffmann-La Roche |
| 16757170 |
40 |
Discovery of 4-substituted-8-(2-hydroxy-2-phenyl-cyclohexyl)-2,8-diaza-spiro[4.5]decan-1-one as a novel class of highly selective GlyT1 inhibitors with improved metabolic stability. |
F. Hoffmann-La Roche |
| 16725323 |
28 |
The synthesis and SAR of 2-arylsulfanylphenyl-1-oxyalkylamino acids as GlyT-1 inhibitors. |
H. Lundbeck |
| 16321523 |
15 |
Sarcosine based indandione hGlyT1 inhibitors. |
Merck Sharp and Dohme Research Laboratories |
| 16246561 |
90 |
Discovery of N-(2-hydroxy-2-aryl-cyclohexyl) substituted spiropiperidines as GlyT1 antagonists with improved pharmacological profile. |
F. Hoffmann-La Roche |
| 16246557 |
75 |
Discovery of N-(2-aryl-cyclohexyl) substituted spiropiperidines as a novel class of GlyT1 inhibitors. |
F. Hoffmann-La Roche |
| 15225720 |
25 |
The synthesis and SAR of 2-arylsulfanyl-phenyl piperazinyl acetic acids as glyT-1 inhibitors. |
H. Lundbeck |
| 12657266 |
3 |
[3H]-(R)-NPTS, a radioligand for the type 1 glycine transporter. |
Pfizer |
| 11495577 |
16 |
The first potent and selective inhibitors of the glycine transporter type 2. |
Organon Laboratories |
| 32527538 |
30 |
Azetidine-based selective glycine transporter-1 (GlyT1) inhibitors with memory enhancing properties. |
Dart Neuroscience |
| 30714733 |
78 |
Development of an N-Acyl Amino Acid That Selectively Inhibits the Glycine Transporter 2 To Produce Analgesia in a Rat Model of Chronic Pain. |
University of Sydney |
| 31223446 |
9 |
Discovery of GlyT2 Inhibitors Using Structure-Based Pharmacophore Screening and Selectivity Studies by FEP+ Calculations. |
The University of Texas At El Paso |
| 27559615 |
76 |
Synthesis and Biological Evaluation of N-((1-(4-(Sulfonyl)piperazin-1-yl)cycloalkyl)methyl)benzamide Inhibitors of Glycine Transporter-1. |
Amri |
| 31404862 |
138 |
Imidazopyridine-based selective and multifunctional ligands of biological targets associated with psychiatric and neurodegenerative diseases. |
Palack£ |
| 31774679 |
14 |
The Druggability of Solute Carriers. |
The Scripps Research Institute |
| 26575458 |
19 |
Potent and selective N-(4-sulfamoylphenyl)thiourea-based GPR55 agonists. |
University of Eastern Finland |
| 29486970 |
46 |
Bicyclo((aryl)methyl)benzamides as inhibitors of GlyT1. |
Astrazeneca |
| 28876062 |
26 |
Modulation of Glycine-Mediated Spinal Neurotransmission for the Treatment of Chronic Pain. |
Albany College of Pharmacy and Health Sciences |
| 29886732 |
300 |
Design and Synthesis of Novel and Selective Glycine Transporter-1 (GlyT1) Inhibitors with Memory Enhancing Properties. |
Dart Neuroscience |
| 30080045 |
42 |
Discovery of Novel Aminotetralines and Aminochromanes as Selective and Competitive Glycine Transporter 1 (GlyT1) Inhibitors. |
Abbvie Deutschland |
| 29969029 |
32 |
De Novo Design, Synthesis, and Biological Evaluation of 3,4-Disubstituted Pyrrolidine Sulfonamides as Potent and Selective Glycine Transporter 1 Competitive Inhibitors. |
Abbvie |
| 19457663 |
1 |
Identification of a disruptor of the MDM2-p53 protein-protein interaction facilitated by high-throughput in silico docking. |
H. Lee Moffitt Cancer Center |
Search and Browse
