Found 74 hits of Enzyme Inhibition Constant Data Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Sodium- and chloride-dependent glycine transporter 1
(Homo sapiens (Human)) | BDBM50195169
(2,4-dichloro-N-((4-(morpholine-4-carbonyl)-1-(prop...)Show SMILES CCCS(=O)(=O)N1CCC(CNC(=O)c2ccc(Cl)cc2Cl)(CC1)C(=O)N1CCOCC1 Show InChI InChI=1S/C21H29Cl2N3O5S/c1-2-13-32(29,30)26-7-5-21(6-8-26,20(28)25-9-11-31-12-10-25)15-24-19(27)17-4-3-16(22)14-18(17)23/h3-4,14H,2,5-13,15H2,1H3,(H,24,27) | PDB
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 2.40 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck and Co.
Curated by ChEMBL
| Assay Description
Inhibition of human GlyT1 |
Bioorg Med Chem Lett 16: 5968-72 (2006)
Article DOI: 10.1016/j.bmcl.2006.08.131
BindingDB Entry DOI: 10.7270/Q2C82B31 |
More data for this
Ligand-Target Pair | |
Sodium- and chloride-dependent glycine transporter 1
(attus norvegicus (Rat)) | BDBM50195169
(2,4-dichloro-N-((4-(morpholine-4-carbonyl)-1-(prop...)Show SMILES CCCS(=O)(=O)N1CCC(CNC(=O)c2ccc(Cl)cc2Cl)(CC1)C(=O)N1CCOCC1 Show InChI InChI=1S/C21H29Cl2N3O5S/c1-2-13-32(29,30)26-7-5-21(6-8-26,20(28)25-9-11-31-12-10-25)15-24-19(27)17-4-3-16(22)14-18(17)23/h3-4,14H,2,5-13,15H2,1H3,(H,24,27) | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 3.20 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck and Co.
Curated by ChEMBL
| Assay Description
Inhibition of rat GlyT1 |
Bioorg Med Chem Lett 16: 5968-72 (2006)
Article DOI: 10.1016/j.bmcl.2006.08.131
BindingDB Entry DOI: 10.7270/Q2C82B31 |
More data for this
Ligand-Target Pair | |
Sodium- and chloride-dependent glycine transporter 1
(Homo sapiens (Human)) | BDBM50195181
(2,4-dichloro-5-fluoro-N-((4-(morpholine-4-carbonyl...)Show SMILES CCCS(=O)(=O)N1CCC(CNC(=O)c2cc(F)c(Cl)cc2Cl)(CC1)C(=O)N1CCOCC1 Show InChI InChI=1S/C21H28Cl2FN3O5S/c1-2-11-33(30,31)27-5-3-21(4-6-27,20(29)26-7-9-32-10-8-26)14-25-19(28)15-12-18(24)17(23)13-16(15)22/h12-13H,2-11,14H2,1H3,(H,25,28) | PDB
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 6.30 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck and Co.
Curated by ChEMBL
| Assay Description
Inhibition of human GlyT1 |
Bioorg Med Chem Lett 16: 5968-72 (2006)
Article DOI: 10.1016/j.bmcl.2006.08.131
BindingDB Entry DOI: 10.7270/Q2C82B31 |
More data for this
Ligand-Target Pair | |
Sodium- and chloride-dependent glycine transporter 1
(attus norvegicus (Rat)) | BDBM50195181
(2,4-dichloro-5-fluoro-N-((4-(morpholine-4-carbonyl...)Show SMILES CCCS(=O)(=O)N1CCC(CNC(=O)c2cc(F)c(Cl)cc2Cl)(CC1)C(=O)N1CCOCC1 Show InChI InChI=1S/C21H28Cl2FN3O5S/c1-2-11-33(30,31)27-5-3-21(4-6-27,20(29)26-7-9-32-10-8-26)14-25-19(28)15-12-18(24)17(23)13-16(15)22/h12-13H,2-11,14H2,1H3,(H,25,28) | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 7.40 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck and Co.
Curated by ChEMBL
| Assay Description
Inhibition of rat GlyT1 |
Bioorg Med Chem Lett 16: 5968-72 (2006)
Article DOI: 10.1016/j.bmcl.2006.08.131
BindingDB Entry DOI: 10.7270/Q2C82B31 |
More data for this
Ligand-Target Pair | |
Sodium- and chloride-dependent glycine transporter 1
(Mus musculus) | BDBM50195169
(2,4-dichloro-N-((4-(morpholine-4-carbonyl)-1-(prop...)Show SMILES CCCS(=O)(=O)N1CCC(CNC(=O)c2ccc(Cl)cc2Cl)(CC1)C(=O)N1CCOCC1 Show InChI InChI=1S/C21H29Cl2N3O5S/c1-2-13-32(29,30)26-7-5-21(6-8-26,20(28)25-9-11-31-12-10-25)15-24-19(27)17-4-3-16(22)14-18(17)23/h3-4,14H,2,5-13,15H2,1H3,(H,24,27) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 7.60 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck and Co.
Curated by ChEMBL
| Assay Description
Inhibition of mouse GlyT1 |
Bioorg Med Chem Lett 16: 5968-72 (2006)
Article DOI: 10.1016/j.bmcl.2006.08.131
BindingDB Entry DOI: 10.7270/Q2C82B31 |
More data for this
Ligand-Target Pair | |
Sodium- and chloride-dependent glycine transporter 1
(Homo sapiens (Human)) | BDBM50195166
(3-chloro-2,6-difluoro-N-((4-(morpholine-4-carbonyl...)Show SMILES CCCS(=O)(=O)N1CCC(CNC(=O)c2c(F)ccc(Cl)c2F)(CC1)C(=O)N1CCOCC1 Show InChI InChI=1S/C21H28ClF2N3O5S/c1-2-13-33(30,31)27-7-5-21(6-8-27,20(29)26-9-11-32-12-10-26)14-25-19(28)17-16(23)4-3-15(22)18(17)24/h3-4H,2,5-14H2,1H3,(H,25,28) | PDB
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 8.40 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck and Co.
Curated by ChEMBL
| Assay Description
Inhibition of human GlyT1 |
Bioorg Med Chem Lett 16: 5968-72 (2006)
Article DOI: 10.1016/j.bmcl.2006.08.131
BindingDB Entry DOI: 10.7270/Q2C82B31 |
More data for this
Ligand-Target Pair | |
Sodium- and chloride-dependent glycine transporter 1
(Homo sapiens (Human)) | BDBM50195170
(2-chloro-N-((4-(morpholine-4-carbonyl)-1-(propylsu...)Show SMILES CCCS(=O)(=O)N1CCC(CNC(=O)c2ccccc2Cl)(CC1)C(=O)N1CCOCC1 Show InChI InChI=1S/C21H30ClN3O5S/c1-2-15-31(28,29)25-9-7-21(8-10-25,20(27)24-11-13-30-14-12-24)16-23-19(26)17-5-3-4-6-18(17)22/h3-6H,2,7-16H2,1H3,(H,23,26) | PDB
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 9.70 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck and Co.
Curated by ChEMBL
| Assay Description
Inhibition of human GlyT1 |
Bioorg Med Chem Lett 16: 5968-72 (2006)
Article DOI: 10.1016/j.bmcl.2006.08.131
BindingDB Entry DOI: 10.7270/Q2C82B31 |
More data for this
Ligand-Target Pair | |
Sodium- and chloride-dependent glycine transporter 1
(attus norvegicus (Rat)) | BDBM50195173
(2-chloro-4-fluoro-N-((4-(morpholine-4-carbonyl)-1-...)Show SMILES CCCS(=O)(=O)N1CCC(CNC(=O)c2ccc(F)cc2Cl)(CC1)C(=O)N1CCOCC1 Show InChI InChI=1S/C21H29ClFN3O5S/c1-2-13-32(29,30)26-7-5-21(6-8-26,20(28)25-9-11-31-12-10-25)15-24-19(27)17-4-3-16(23)14-18(17)22/h3-4,14H,2,5-13,15H2,1H3,(H,24,27) | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck and Co.
Curated by ChEMBL
| Assay Description
Inhibition of rat GlyT1 |
Bioorg Med Chem Lett 16: 5968-72 (2006)
Article DOI: 10.1016/j.bmcl.2006.08.131
BindingDB Entry DOI: 10.7270/Q2C82B31 |
More data for this
Ligand-Target Pair | |
Sodium- and chloride-dependent glycine transporter 1
(Homo sapiens (Human)) | BDBM50195173
(2-chloro-4-fluoro-N-((4-(morpholine-4-carbonyl)-1-...)Show SMILES CCCS(=O)(=O)N1CCC(CNC(=O)c2ccc(F)cc2Cl)(CC1)C(=O)N1CCOCC1 Show InChI InChI=1S/C21H29ClFN3O5S/c1-2-13-32(29,30)26-7-5-21(6-8-26,20(28)25-9-11-31-12-10-25)15-24-19(27)17-4-3-16(23)14-18(17)22/h3-4,14H,2,5-13,15H2,1H3,(H,24,27) | PDB
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 13 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck and Co.
Curated by ChEMBL
| Assay Description
Inhibition of human GlyT1 |
Bioorg Med Chem Lett 16: 5968-72 (2006)
Article DOI: 10.1016/j.bmcl.2006.08.131
BindingDB Entry DOI: 10.7270/Q2C82B31 |
More data for this
Ligand-Target Pair | |
Sodium- and chloride-dependent glycine transporter 1
(Homo sapiens (Human)) | BDBM50195178
(2-chloro-6-fluoro-N-((4-(morpholine-4-carbonyl)-1-...)Show SMILES CCCS(=O)(=O)N1CCC(CNC(=O)c2c(F)cccc2Cl)(CC1)C(=O)N1CCOCC1 Show InChI InChI=1S/C21H29ClFN3O5S/c1-2-14-32(29,30)26-8-6-21(7-9-26,20(28)25-10-12-31-13-11-25)15-24-19(27)18-16(22)4-3-5-17(18)23/h3-5H,2,6-15H2,1H3,(H,24,27) | PDB
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 13 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck and Co.
Curated by ChEMBL
| Assay Description
Inhibition of human GlyT1 |
Bioorg Med Chem Lett 16: 5968-72 (2006)
Article DOI: 10.1016/j.bmcl.2006.08.131
BindingDB Entry DOI: 10.7270/Q2C82B31 |
More data for this
Ligand-Target Pair | |
Sodium- and chloride-dependent glycine transporter 1
(attus norvegicus (Rat)) | BDBM50195170
(2-chloro-N-((4-(morpholine-4-carbonyl)-1-(propylsu...)Show SMILES CCCS(=O)(=O)N1CCC(CNC(=O)c2ccccc2Cl)(CC1)C(=O)N1CCOCC1 Show InChI InChI=1S/C21H30ClN3O5S/c1-2-15-31(28,29)25-9-7-21(8-10-25,20(27)24-11-13-30-14-12-24)16-23-19(26)17-5-3-4-6-18(17)22/h3-6H,2,7-16H2,1H3,(H,23,26) | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 18 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck and Co.
Curated by ChEMBL
| Assay Description
Inhibition of rat GlyT1 |
Bioorg Med Chem Lett 16: 5968-72 (2006)
Article DOI: 10.1016/j.bmcl.2006.08.131
BindingDB Entry DOI: 10.7270/Q2C82B31 |
More data for this
Ligand-Target Pair | |
Sodium- and chloride-dependent glycine transporter 1
(Mus musculus) | BDBM50195181
(2,4-dichloro-5-fluoro-N-((4-(morpholine-4-carbonyl...)Show SMILES CCCS(=O)(=O)N1CCC(CNC(=O)c2cc(F)c(Cl)cc2Cl)(CC1)C(=O)N1CCOCC1 Show InChI InChI=1S/C21H28Cl2FN3O5S/c1-2-11-33(30,31)27-5-3-21(4-6-27,20(29)26-7-9-32-10-8-26)14-25-19(28)15-12-18(24)17(23)13-16(15)22/h12-13H,2-11,14H2,1H3,(H,25,28) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 19 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck and Co.
Curated by ChEMBL
| Assay Description
Inhibition of mouse GlyT1 |
Bioorg Med Chem Lett 16: 5968-72 (2006)
Article DOI: 10.1016/j.bmcl.2006.08.131
BindingDB Entry DOI: 10.7270/Q2C82B31 |
More data for this
Ligand-Target Pair | |
Sodium- and chloride-dependent glycine transporter 1
(attus norvegicus (Rat)) | BDBM50195166
(3-chloro-2,6-difluoro-N-((4-(morpholine-4-carbonyl...)Show SMILES CCCS(=O)(=O)N1CCC(CNC(=O)c2c(F)ccc(Cl)c2F)(CC1)C(=O)N1CCOCC1 Show InChI InChI=1S/C21H28ClF2N3O5S/c1-2-13-33(30,31)27-7-5-21(6-8-27,20(29)26-9-11-32-12-10-26)14-25-19(28)17-16(23)4-3-15(22)18(17)24/h3-4H,2,5-14H2,1H3,(H,25,28) | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck and Co.
Curated by ChEMBL
| Assay Description
Inhibition of rat GlyT1 |
Bioorg Med Chem Lett 16: 5968-72 (2006)
Article DOI: 10.1016/j.bmcl.2006.08.131
BindingDB Entry DOI: 10.7270/Q2C82B31 |
More data for this
Ligand-Target Pair | |
Sodium- and chloride-dependent glycine transporter 1
(attus norvegicus (Rat)) | BDBM50195178
(2-chloro-6-fluoro-N-((4-(morpholine-4-carbonyl)-1-...)Show SMILES CCCS(=O)(=O)N1CCC(CNC(=O)c2c(F)cccc2Cl)(CC1)C(=O)N1CCOCC1 Show InChI InChI=1S/C21H29ClFN3O5S/c1-2-14-32(29,30)26-8-6-21(7-9-26,20(28)25-10-12-31-13-11-25)15-24-19(27)18-16(22)4-3-5-17(18)23/h3-5H,2,6-15H2,1H3,(H,24,27) | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 22 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck and Co.
Curated by ChEMBL
| Assay Description
Inhibition of rat GlyT1 |
Bioorg Med Chem Lett 16: 5968-72 (2006)
Article DOI: 10.1016/j.bmcl.2006.08.131
BindingDB Entry DOI: 10.7270/Q2C82B31 |
More data for this
Ligand-Target Pair | |
Sodium- and chloride-dependent glycine transporter 1
(Mus musculus) | BDBM50195173
(2-chloro-4-fluoro-N-((4-(morpholine-4-carbonyl)-1-...)Show SMILES CCCS(=O)(=O)N1CCC(CNC(=O)c2ccc(F)cc2Cl)(CC1)C(=O)N1CCOCC1 Show InChI InChI=1S/C21H29ClFN3O5S/c1-2-13-32(29,30)26-7-5-21(6-8-26,20(28)25-9-11-31-12-10-25)15-24-19(27)17-4-3-16(23)14-18(17)22/h3-4,14H,2,5-13,15H2,1H3,(H,24,27) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 29 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck and Co.
Curated by ChEMBL
| Assay Description
Inhibition of mouse GlyT1 |
Bioorg Med Chem Lett 16: 5968-72 (2006)
Article DOI: 10.1016/j.bmcl.2006.08.131
BindingDB Entry DOI: 10.7270/Q2C82B31 |
More data for this
Ligand-Target Pair | |
Sodium- and chloride-dependent glycine transporter 1
(Homo sapiens (Human)) | BDBM50195168
(2-fluoro-N-((4-(morpholine-4-carbonyl)-1-(propylsu...)Show SMILES CCCS(=O)(=O)N1CCC(CNC(=O)c2ccc(cc2F)C(F)(F)F)(CC1)C(=O)N1CCOCC1 Show InChI InChI=1S/C22H29F4N3O5S/c1-2-13-35(32,33)29-7-5-21(6-8-29,20(31)28-9-11-34-12-10-28)15-27-19(30)17-4-3-16(14-18(17)23)22(24,25)26/h3-4,14H,2,5-13,15H2,1H3,(H,27,30) | PDB
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 43 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck and Co.
Curated by ChEMBL
| Assay Description
Inhibition of human GlyT1 |
Bioorg Med Chem Lett 16: 5968-72 (2006)
Article DOI: 10.1016/j.bmcl.2006.08.131
BindingDB Entry DOI: 10.7270/Q2C82B31 |
More data for this
Ligand-Target Pair | |
Sodium- and chloride-dependent glycine transporter 1
(Mus musculus) | BDBM50195166
(3-chloro-2,6-difluoro-N-((4-(morpholine-4-carbonyl...)Show SMILES CCCS(=O)(=O)N1CCC(CNC(=O)c2c(F)ccc(Cl)c2F)(CC1)C(=O)N1CCOCC1 Show InChI InChI=1S/C21H28ClF2N3O5S/c1-2-13-33(30,31)27-7-5-21(6-8-27,20(29)26-9-11-32-12-10-26)14-25-19(28)17-16(23)4-3-15(22)18(17)24/h3-4H,2,5-14H2,1H3,(H,25,28) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 43 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck and Co.
Curated by ChEMBL
| Assay Description
Inhibition of mouse GlyT1 |
Bioorg Med Chem Lett 16: 5968-72 (2006)
Article DOI: 10.1016/j.bmcl.2006.08.131
BindingDB Entry DOI: 10.7270/Q2C82B31 |
More data for this
Ligand-Target Pair | |
Sodium- and chloride-dependent glycine transporter 1
(Mus musculus) | BDBM50195178
(2-chloro-6-fluoro-N-((4-(morpholine-4-carbonyl)-1-...)Show SMILES CCCS(=O)(=O)N1CCC(CNC(=O)c2c(F)cccc2Cl)(CC1)C(=O)N1CCOCC1 Show InChI InChI=1S/C21H29ClFN3O5S/c1-2-14-32(29,30)26-8-6-21(7-9-26,20(28)25-10-12-31-13-11-25)15-24-19(27)18-16(22)4-3-5-17(18)23/h3-5H,2,6-15H2,1H3,(H,24,27) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 57 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck and Co.
Curated by ChEMBL
| Assay Description
Inhibition of mouse GlyT1 |
Bioorg Med Chem Lett 16: 5968-72 (2006)
Article DOI: 10.1016/j.bmcl.2006.08.131
BindingDB Entry DOI: 10.7270/Q2C82B31 |
More data for this
Ligand-Target Pair | |
Sodium- and chloride-dependent glycine transporter 1
(Homo sapiens (Human)) | BDBM50195167
(4-fluoro-N-((4-(morpholine-4-carbonyl)-1-(propylsu...)Show SMILES CCCS(=O)(=O)N1CCC(CNC(=O)c2ccc(F)cc2C(F)(F)F)(CC1)C(=O)N1CCOCC1 Show InChI InChI=1S/C22H29F4N3O5S/c1-2-13-35(32,33)29-7-5-21(6-8-29,20(31)28-9-11-34-12-10-28)15-27-19(30)17-4-3-16(23)14-18(17)22(24,25)26/h3-4,14H,2,5-13,15H2,1H3,(H,27,30) | PDB
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 68 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck and Co.
Curated by ChEMBL
| Assay Description
Inhibition of human GlyT1 |
Bioorg Med Chem Lett 16: 5968-72 (2006)
Article DOI: 10.1016/j.bmcl.2006.08.131
BindingDB Entry DOI: 10.7270/Q2C82B31 |
More data for this
Ligand-Target Pair | |
Sodium- and chloride-dependent glycine transporter 1
(Homo sapiens (Human)) | BDBM50195171
(4-((2,4-dichlorobenzamido)methyl)-N-((3-methyloxet...)Show SMILES CCCS(=O)(=O)N1CCC(CNC(=O)c2ccc(Cl)cc2Cl)(CC1)C(=O)NCC1(C)COC1 Show InChI InChI=1S/C22H31Cl2N3O5S/c1-3-10-33(30,31)27-8-6-22(7-9-27,20(29)26-12-21(2)14-32-15-21)13-25-19(28)17-5-4-16(23)11-18(17)24/h4-5,11H,3,6-10,12-15H2,1-2H3,(H,25,28)(H,26,29) | PDB
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| n/a | n/a | 69 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck and Co.
Curated by ChEMBL
| Assay Description
Inhibition of human GlyT1 |
Bioorg Med Chem Lett 16: 5968-72 (2006)
Article DOI: 10.1016/j.bmcl.2006.08.131
BindingDB Entry DOI: 10.7270/Q2C82B31 |
More data for this
Ligand-Target Pair | |
Sodium- and chloride-dependent glycine transporter 1
(Homo sapiens (Human)) | BDBM50195172
(CHEMBL220987 | N-((4-(morpholine-4-carbonyl)-1-(pr...)Show SMILES CCCS(=O)(=O)N1CCC(CNC(=O)c2ccccc2OC(F)(F)F)(CC1)C(=O)N1CCOCC1 Show InChI InChI=1S/C22H30F3N3O6S/c1-2-15-35(31,32)28-9-7-21(8-10-28,20(30)27-11-13-33-14-12-27)16-26-19(29)17-5-3-4-6-18(17)34-22(23,24)25/h3-6H,2,7-16H2,1H3,(H,26,29) | PDB
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| n/a | n/a | 88 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck and Co.
Curated by ChEMBL
| Assay Description
Inhibition of human GlyT1 |
Bioorg Med Chem Lett 16: 5968-72 (2006)
Article DOI: 10.1016/j.bmcl.2006.08.131
BindingDB Entry DOI: 10.7270/Q2C82B31 |
More data for this
Ligand-Target Pair | |
Sodium- and chloride-dependent glycine transporter 1
(Mus musculus) | BDBM50195170
(2-chloro-N-((4-(morpholine-4-carbonyl)-1-(propylsu...)Show SMILES CCCS(=O)(=O)N1CCC(CNC(=O)c2ccccc2Cl)(CC1)C(=O)N1CCOCC1 Show InChI InChI=1S/C21H30ClN3O5S/c1-2-15-31(28,29)25-9-7-21(8-10-25,20(27)24-11-13-30-14-12-24)16-23-19(26)17-5-3-4-6-18(17)22/h3-6H,2,7-16H2,1H3,(H,23,26) | PDB
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| n/a | n/a | 95 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck and Co.
Curated by ChEMBL
| Assay Description
Inhibition of mouse GlyT1 |
Bioorg Med Chem Lett 16: 5968-72 (2006)
Article DOI: 10.1016/j.bmcl.2006.08.131
BindingDB Entry DOI: 10.7270/Q2C82B31 |
More data for this
Ligand-Target Pair | |
Sodium- and chloride-dependent glycine transporter 1
(Homo sapiens (Human)) | BDBM50195175
(CHEMBL223491 | N-((4-(3-aminoazetidine-1-carbonyl)...)Show SMILES CCCS(=O)(=O)N1CCC(CNC(=O)c2ccc(Cl)cc2Cl)(CC1)C(=O)N1CC(N)C1 Show InChI InChI=1S/C20H28Cl2N4O4S/c1-2-9-31(29,30)26-7-5-20(6-8-26,19(28)25-11-15(23)12-25)13-24-18(27)16-4-3-14(21)10-17(16)22/h3-4,10,15H,2,5-9,11-13,23H2,1H3,(H,24,27) | PDB
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| n/a | n/a | 109 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck and Co.
Curated by ChEMBL
| Assay Description
Inhibition of human GlyT1 |
Bioorg Med Chem Lett 16: 5968-72 (2006)
Article DOI: 10.1016/j.bmcl.2006.08.131
BindingDB Entry DOI: 10.7270/Q2C82B31 |
More data for this
Ligand-Target Pair | |
Sodium- and chloride-dependent glycine transporter 1
(Homo sapiens (Human)) | BDBM50195179
(2,6-difluoro-N-((4-(morpholine-4-carbonyl)-1-(prop...)Show SMILES CCCS(=O)(=O)N1CCC(CNC(=O)c2c(F)cccc2F)(CC1)C(=O)N1CCOCC1 Show InChI InChI=1S/C21H29F2N3O5S/c1-2-14-32(29,30)26-8-6-21(7-9-26,20(28)25-10-12-31-13-11-25)15-24-19(27)18-16(22)4-3-5-17(18)23/h3-5H,2,6-15H2,1H3,(H,24,27) | PDB
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| n/a | n/a | 131 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck and Co.
Curated by ChEMBL
| Assay Description
Inhibition of human GlyT1 |
Bioorg Med Chem Lett 16: 5968-72 (2006)
Article DOI: 10.1016/j.bmcl.2006.08.131
BindingDB Entry DOI: 10.7270/Q2C82B31 |
More data for this
Ligand-Target Pair | |
Sodium- and chloride-dependent glycine transporter 1
(Homo sapiens (Human)) | BDBM50195163
(4-((2,4-dichlorobenzamido)methyl)-N,N-dimethyl-1-(...)Show SMILES CCCS(=O)(=O)N1CCC(CNC(=O)c2ccc(Cl)cc2Cl)(CC1)C(=O)N(C)C Show InChI InChI=1S/C19H27Cl2N3O4S/c1-4-11-29(27,28)24-9-7-19(8-10-24,18(26)23(2)3)13-22-17(25)15-6-5-14(20)12-16(15)21/h5-6,12H,4,7-11,13H2,1-3H3,(H,22,25) | PDB
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| n/a | n/a | 181 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck and Co.
Curated by ChEMBL
| Assay Description
Inhibition of human GlyT1 |
Bioorg Med Chem Lett 16: 5968-72 (2006)
Article DOI: 10.1016/j.bmcl.2006.08.131
BindingDB Entry DOI: 10.7270/Q2C82B31 |
More data for this
Ligand-Target Pair | |
Sodium- and chloride-dependent glycine transporter 1
(Homo sapiens (Human)) | BDBM50195174
(CHEMBL220948 | N-((4-(morpholine-4-carbonyl)-1-(pr...)Show SMILES CCCS(=O)(=O)N1CCC(CNC(=O)c2ccccc2)(CC1)C(=O)N1CCOCC1 Show InChI InChI=1S/C21H31N3O5S/c1-2-16-30(27,28)24-10-8-21(9-11-24,20(26)23-12-14-29-15-13-23)17-22-19(25)18-6-4-3-5-7-18/h3-7H,2,8-17H2,1H3,(H,22,25) | PDB
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| n/a | n/a | 264 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck and Co.
Curated by ChEMBL
| Assay Description
Inhibition of human GlyT1 |
Bioorg Med Chem Lett 16: 5968-72 (2006)
Article DOI: 10.1016/j.bmcl.2006.08.131
BindingDB Entry DOI: 10.7270/Q2C82B31 |
More data for this
Ligand-Target Pair | |
Sodium- and chloride-dependent glycine transporter 1
(Homo sapiens (Human)) | BDBM50195165
(2,4-dichloro-N-((4-(cyclopropanecarbonyl)-1-(propy...)Show SMILES CCCS(=O)(=O)N1CCC(CNC(=O)c2ccc(Cl)cc2Cl)(CC1)C(=O)C1CC1 Show InChI InChI=1S/C20H26Cl2N2O4S/c1-2-11-29(27,28)24-9-7-20(8-10-24,18(25)14-3-4-14)13-23-19(26)16-6-5-15(21)12-17(16)22/h5-6,12,14H,2-4,7-11,13H2,1H3,(H,23,26) | PDB
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| n/a | n/a | 472 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck and Co.
Curated by ChEMBL
| Assay Description
Inhibition of human GlyT1 |
Bioorg Med Chem Lett 16: 5968-72 (2006)
Article DOI: 10.1016/j.bmcl.2006.08.131
BindingDB Entry DOI: 10.7270/Q2C82B31 |
More data for this
Ligand-Target Pair | |
Sodium- and chloride-dependent glycine transporter 1
(Homo sapiens (Human)) | BDBM50195180
(4-((2,4-dichlorobenzamido)methyl)-N-ethyl-1-(propy...)Show SMILES CCCS(=O)(=O)N1CCC(CNC(=O)c2ccc(Cl)cc2Cl)(CC1)C(=O)NCC Show InChI InChI=1S/C19H27Cl2N3O4S/c1-3-11-29(27,28)24-9-7-19(8-10-24,18(26)22-4-2)13-23-17(25)15-6-5-14(20)12-16(15)21/h5-6,12H,3-4,7-11,13H2,1-2H3,(H,22,26)(H,23,25) | PDB
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| n/a | n/a | 517 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck and Co.
Curated by ChEMBL
| Assay Description
Inhibition of human GlyT1 |
Bioorg Med Chem Lett 16: 5968-72 (2006)
Article DOI: 10.1016/j.bmcl.2006.08.131
BindingDB Entry DOI: 10.7270/Q2C82B31 |
More data for this
Ligand-Target Pair | |
Sodium- and chloride-dependent glycine transporter 1
(Homo sapiens (Human)) | BDBM50195183
(2,4-dichloro-N-((4-(3-(dimethylamino)pyrrolidine-1...)Show SMILES CCCS(=O)(=O)N1CCC(CNC(=O)c2ccc(Cl)cc2Cl)(CC1)C(=O)N1CCC(C1)N(C)C Show InChI InChI=1S/C23H34Cl2N4O4S/c1-4-13-34(32,33)29-11-8-23(9-12-29,22(31)28-10-7-18(15-28)27(2)3)16-26-21(30)19-6-5-17(24)14-20(19)25/h5-6,14,18H,4,7-13,15-16H2,1-3H3,(H,26,30) | PDB
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| n/a | n/a | 544 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck and Co.
Curated by ChEMBL
| Assay Description
Inhibition of human GlyT1 |
Bioorg Med Chem Lett 16: 5968-72 (2006)
Article DOI: 10.1016/j.bmcl.2006.08.131
BindingDB Entry DOI: 10.7270/Q2C82B31 |
More data for this
Ligand-Target Pair | |
Sodium- and chloride-dependent glycine transporter 1
(Homo sapiens (Human)) | BDBM50195177
(CHEMBL373556 | N-((4-(morpholine-4-carbonyl)-1-(pr...)Show SMILES CCCS(=O)(=O)N1CCC(CNC(=O)CC)(CC1)C(=O)N1CCOCC1 Show InChI InChI=1S/C17H31N3O5S/c1-3-13-26(23,24)20-7-5-17(6-8-20,14-18-15(21)4-2)16(22)19-9-11-25-12-10-19/h3-14H2,1-2H3,(H,18,21) | PDB
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| n/a | n/a | >5.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck and Co.
Curated by ChEMBL
| Assay Description
Inhibition of human GlyT1 |
Bioorg Med Chem Lett 16: 5968-72 (2006)
Article DOI: 10.1016/j.bmcl.2006.08.131
BindingDB Entry DOI: 10.7270/Q2C82B31 |
More data for this
Ligand-Target Pair | |
Sodium- and chloride-dependent glycine transporter 1
(Homo sapiens (Human)) | BDBM50195176
((S)-2,4-dichloro-N-(1-(4-(morpholine-4-carbonyl)-1...)Show SMILES CCCS(=O)(=O)N1CCC(CC1)([C@H](C)NC(=O)c1ccc(Cl)cc1Cl)C(=O)N1CCOCC1 Show InChI InChI=1S/C22H31Cl2N3O5S/c1-3-14-33(30,31)27-8-6-22(7-9-27,21(29)26-10-12-32-13-11-26)16(2)25-20(28)18-5-4-17(23)15-19(18)24/h4-5,15-16H,3,6-14H2,1-2H3,(H,25,28)/t16-/m0/s1 | PDB
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| n/a | n/a | >5.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck and Co.
Curated by ChEMBL
| Assay Description
Inhibition of human GlyT1 |
Bioorg Med Chem Lett 16: 5968-72 (2006)
Article DOI: 10.1016/j.bmcl.2006.08.131
BindingDB Entry DOI: 10.7270/Q2C82B31 |
More data for this
Ligand-Target Pair | |
Sodium- and chloride-dependent glycine transporter 1
(Homo sapiens (Human)) | BDBM50195182
((R)-2,4-dichloro-N-(1-(4-(morpholine-4-carbonyl)-1...)Show SMILES CCCS(=O)(=O)N1CCC(CC1)([C@@H](C)NC(=O)c1ccc(Cl)cc1Cl)C(=O)N1CCOCC1 Show InChI InChI=1S/C22H31Cl2N3O5S/c1-3-14-33(30,31)27-8-6-22(7-9-27,21(29)26-10-12-32-13-11-26)16(2)25-20(28)18-5-4-17(23)15-19(18)24/h4-5,15-16H,3,6-14H2,1-2H3,(H,25,28)/t16-/m1/s1 | PDB
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| n/a | n/a | >5.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck and Co.
Curated by ChEMBL
| Assay Description
Inhibition of human GlyT1 |
Bioorg Med Chem Lett 16: 5968-72 (2006)
Article DOI: 10.1016/j.bmcl.2006.08.131
BindingDB Entry DOI: 10.7270/Q2C82B31 |
More data for this
Ligand-Target Pair | |
Sodium- and chloride-dependent glycine transporter 1
(Homo sapiens (Human)) | BDBM50195164
(CHEMBL220179 | N-((4-(morpholine-4-carbonyl)-1-(pr...)Show SMILES CCCS(=O)(=O)N1CCC(CNC(=O)C2CC2)(CC1)C(=O)N1CCOCC1 Show InChI InChI=1S/C18H31N3O5S/c1-2-13-27(24,25)21-7-5-18(6-8-21,14-19-16(22)15-3-4-15)17(23)20-9-11-26-12-10-20/h15H,2-14H2,1H3,(H,19,22) | PDB
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| n/a | n/a | >5.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck and Co.
Curated by ChEMBL
| Assay Description
Inhibition of human GlyT1 |
Bioorg Med Chem Lett 16: 5968-72 (2006)
Article DOI: 10.1016/j.bmcl.2006.08.131
BindingDB Entry DOI: 10.7270/Q2C82B31 |
More data for this
Ligand-Target Pair | |
Sodium- and chloride-dependent glycine transporter 1
(Homo sapiens (Human)) | BDBM50195162
(2,4-dichloro-N-((4-(1-methylpiperazine-4-carbonyl)...)Show SMILES CCCS(=O)(=O)N1CCC(CNC(=O)c2ccc(Cl)cc2Cl)(CC1)C(=O)N1CCN(C)CC1 Show InChI InChI=1S/C22H32Cl2N4O4S/c1-3-14-33(31,32)28-8-6-22(7-9-28,21(30)27-12-10-26(2)11-13-27)16-25-20(29)18-5-4-17(23)15-19(18)24/h4-5,15H,3,6-14,16H2,1-2H3,(H,25,29) | PDB
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| n/a | n/a | >5.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck and Co.
Curated by ChEMBL
| Assay Description
Inhibition of human GlyT1 |
Bioorg Med Chem Lett 16: 5968-72 (2006)
Article DOI: 10.1016/j.bmcl.2006.08.131
BindingDB Entry DOI: 10.7270/Q2C82B31 |
More data for this
Ligand-Target Pair | |
Sodium- and chloride-dependent taurine transporter
(Homo sapiens (Human)) | BDBM50195171
(4-((2,4-dichlorobenzamido)methyl)-N-((3-methyloxet...)Show SMILES CCCS(=O)(=O)N1CCC(CNC(=O)c2ccc(Cl)cc2Cl)(CC1)C(=O)NCC1(C)COC1 Show InChI InChI=1S/C22H31Cl2N3O5S/c1-3-10-33(30,31)27-8-6-22(7-9-27,20(29)26-12-21(2)14-32-15-21)13-25-19(28)17-5-4-16(23)11-18(17)24/h4-5,11H,3,6-10,12-15H2,1-2H3,(H,25,28)(H,26,29) | Reactome pathway
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| n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck and Co.
Curated by ChEMBL
| Assay Description
Inhibition of human TauT |
Bioorg Med Chem Lett 16: 5968-72 (2006)
Article DOI: 10.1016/j.bmcl.2006.08.131
BindingDB Entry DOI: 10.7270/Q2C82B31 |
More data for this
Ligand-Target Pair | |
Sodium- and chloride-dependent taurine transporter
(Homo sapiens (Human)) | BDBM50195173
(2-chloro-4-fluoro-N-((4-(morpholine-4-carbonyl)-1-...)Show SMILES CCCS(=O)(=O)N1CCC(CNC(=O)c2ccc(F)cc2Cl)(CC1)C(=O)N1CCOCC1 Show InChI InChI=1S/C21H29ClFN3O5S/c1-2-13-32(29,30)26-7-5-21(6-8-26,20(28)25-9-11-31-12-10-25)15-24-19(27)17-4-3-16(23)14-18(17)22/h3-4,14H,2,5-13,15H2,1H3,(H,24,27) | Reactome pathway
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| n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck and Co.
Curated by ChEMBL
| Assay Description
Inhibition of human TauT |
Bioorg Med Chem Lett 16: 5968-72 (2006)
Article DOI: 10.1016/j.bmcl.2006.08.131
BindingDB Entry DOI: 10.7270/Q2C82B31 |
More data for this
Ligand-Target Pair | |
Sodium- and chloride-dependent taurine transporter
(Homo sapiens (Human)) | BDBM50195179
(2,6-difluoro-N-((4-(morpholine-4-carbonyl)-1-(prop...)Show SMILES CCCS(=O)(=O)N1CCC(CNC(=O)c2c(F)cccc2F)(CC1)C(=O)N1CCOCC1 Show InChI InChI=1S/C21H29F2N3O5S/c1-2-14-32(29,30)26-8-6-21(7-9-26,20(28)25-10-12-31-13-11-25)15-24-19(27)18-16(22)4-3-5-17(18)23/h3-5H,2,6-15H2,1H3,(H,24,27) | Reactome pathway
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| n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck and Co.
Curated by ChEMBL
| Assay Description
Inhibition of human TauT |
Bioorg Med Chem Lett 16: 5968-72 (2006)
Article DOI: 10.1016/j.bmcl.2006.08.131
BindingDB Entry DOI: 10.7270/Q2C82B31 |
More data for this
Ligand-Target Pair | |
Sodium- and chloride-dependent taurine transporter
(Homo sapiens (Human)) | BDBM50195177
(CHEMBL373556 | N-((4-(morpholine-4-carbonyl)-1-(pr...)Show SMILES CCCS(=O)(=O)N1CCC(CNC(=O)CC)(CC1)C(=O)N1CCOCC1 Show InChI InChI=1S/C17H31N3O5S/c1-3-13-26(23,24)20-7-5-17(6-8-20,14-18-15(21)4-2)16(22)19-9-11-25-12-10-19/h3-14H2,1-2H3,(H,18,21) | Reactome pathway
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PubMed
| n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck and Co.
Curated by ChEMBL
| Assay Description
Inhibition of human TauT |
Bioorg Med Chem Lett 16: 5968-72 (2006)
Article DOI: 10.1016/j.bmcl.2006.08.131
BindingDB Entry DOI: 10.7270/Q2C82B31 |
More data for this
Ligand-Target Pair | |
Sodium- and chloride-dependent taurine transporter
(Homo sapiens (Human)) | BDBM50195180
(4-((2,4-dichlorobenzamido)methyl)-N-ethyl-1-(propy...)Show SMILES CCCS(=O)(=O)N1CCC(CNC(=O)c2ccc(Cl)cc2Cl)(CC1)C(=O)NCC Show InChI InChI=1S/C19H27Cl2N3O4S/c1-3-11-29(27,28)24-9-7-19(8-10-24,18(26)22-4-2)13-23-17(25)15-6-5-14(20)12-16(15)21/h5-6,12H,3-4,7-11,13H2,1-2H3,(H,22,26)(H,23,25) | Reactome pathway
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PubMed
| n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck and Co.
Curated by ChEMBL
| Assay Description
Inhibition of human TauT |
Bioorg Med Chem Lett 16: 5968-72 (2006)
Article DOI: 10.1016/j.bmcl.2006.08.131
BindingDB Entry DOI: 10.7270/Q2C82B31 |
More data for this
Ligand-Target Pair | |
Sodium- and chloride-dependent glycine transporter 2
(Homo sapiens (Human)) | BDBM50195177
(CHEMBL373556 | N-((4-(morpholine-4-carbonyl)-1-(pr...)Show SMILES CCCS(=O)(=O)N1CCC(CNC(=O)CC)(CC1)C(=O)N1CCOCC1 Show InChI InChI=1S/C17H31N3O5S/c1-3-13-26(23,24)20-7-5-17(6-8-20,14-18-15(21)4-2)16(22)19-9-11-25-12-10-19/h3-14H2,1-2H3,(H,18,21) | Reactome pathway
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| n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck and Co.
Curated by ChEMBL
| Assay Description
Inhibition of human GlyT2 |
Bioorg Med Chem Lett 16: 5968-72 (2006)
Article DOI: 10.1016/j.bmcl.2006.08.131
BindingDB Entry DOI: 10.7270/Q2C82B31 |
More data for this
Ligand-Target Pair | |
Sodium- and chloride-dependent glycine transporter 2
(Homo sapiens (Human)) | BDBM50195169
(2,4-dichloro-N-((4-(morpholine-4-carbonyl)-1-(prop...)Show SMILES CCCS(=O)(=O)N1CCC(CNC(=O)c2ccc(Cl)cc2Cl)(CC1)C(=O)N1CCOCC1 Show InChI InChI=1S/C21H29Cl2N3O5S/c1-2-13-32(29,30)26-7-5-21(6-8-26,20(28)25-9-11-31-12-10-25)15-24-19(27)17-4-3-16(22)14-18(17)23/h3-4,14H,2,5-13,15H2,1H3,(H,24,27) | Reactome pathway
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| n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck and Co.
Curated by ChEMBL
| Assay Description
Inhibition of human GlyT2 |
Bioorg Med Chem Lett 16: 5968-72 (2006)
Article DOI: 10.1016/j.bmcl.2006.08.131
BindingDB Entry DOI: 10.7270/Q2C82B31 |
More data for this
Ligand-Target Pair | |
Sodium- and chloride-dependent glycine transporter 2
(Homo sapiens (Human)) | BDBM50195168
(2-fluoro-N-((4-(morpholine-4-carbonyl)-1-(propylsu...)Show SMILES CCCS(=O)(=O)N1CCC(CNC(=O)c2ccc(cc2F)C(F)(F)F)(CC1)C(=O)N1CCOCC1 Show InChI InChI=1S/C22H29F4N3O5S/c1-2-13-35(32,33)29-7-5-21(6-8-29,20(31)28-9-11-34-12-10-28)15-27-19(30)17-4-3-16(14-18(17)23)22(24,25)26/h3-4,14H,2,5-13,15H2,1H3,(H,27,30) | Reactome pathway
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| n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck and Co.
Curated by ChEMBL
| Assay Description
Inhibition of human GlyT2 |
Bioorg Med Chem Lett 16: 5968-72 (2006)
Article DOI: 10.1016/j.bmcl.2006.08.131
BindingDB Entry DOI: 10.7270/Q2C82B31 |
More data for this
Ligand-Target Pair | |
Sodium- and chloride-dependent glycine transporter 2
(Homo sapiens (Human)) | BDBM50195180
(4-((2,4-dichlorobenzamido)methyl)-N-ethyl-1-(propy...)Show SMILES CCCS(=O)(=O)N1CCC(CNC(=O)c2ccc(Cl)cc2Cl)(CC1)C(=O)NCC Show InChI InChI=1S/C19H27Cl2N3O4S/c1-3-11-29(27,28)24-9-7-19(8-10-24,18(26)22-4-2)13-23-17(25)15-6-5-14(20)12-16(15)21/h5-6,12H,3-4,7-11,13H2,1-2H3,(H,22,26)(H,23,25) | Reactome pathway
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| n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck and Co.
Curated by ChEMBL
| Assay Description
Inhibition of human GlyT2 |
Bioorg Med Chem Lett 16: 5968-72 (2006)
Article DOI: 10.1016/j.bmcl.2006.08.131
BindingDB Entry DOI: 10.7270/Q2C82B31 |
More data for this
Ligand-Target Pair | |
Sodium- and chloride-dependent glycine transporter 2
(Homo sapiens (Human)) | BDBM50195166
(3-chloro-2,6-difluoro-N-((4-(morpholine-4-carbonyl...)Show SMILES CCCS(=O)(=O)N1CCC(CNC(=O)c2c(F)ccc(Cl)c2F)(CC1)C(=O)N1CCOCC1 Show InChI InChI=1S/C21H28ClF2N3O5S/c1-2-13-33(30,31)27-7-5-21(6-8-27,20(29)26-9-11-32-12-10-26)14-25-19(28)17-16(23)4-3-15(22)18(17)24/h3-4H,2,5-14H2,1H3,(H,25,28) | Reactome pathway
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| n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck and Co.
Curated by ChEMBL
| Assay Description
Inhibition of human GlyT2 |
Bioorg Med Chem Lett 16: 5968-72 (2006)
Article DOI: 10.1016/j.bmcl.2006.08.131
BindingDB Entry DOI: 10.7270/Q2C82B31 |
More data for this
Ligand-Target Pair | |
Sodium- and chloride-dependent glycine transporter 2
(Homo sapiens (Human)) | BDBM50195165
(2,4-dichloro-N-((4-(cyclopropanecarbonyl)-1-(propy...)Show SMILES CCCS(=O)(=O)N1CCC(CNC(=O)c2ccc(Cl)cc2Cl)(CC1)C(=O)C1CC1 Show InChI InChI=1S/C20H26Cl2N2O4S/c1-2-11-29(27,28)24-9-7-20(8-10-24,18(25)14-3-4-14)13-23-19(26)16-6-5-15(21)12-17(16)22/h5-6,12,14H,2-4,7-11,13H2,1H3,(H,23,26) | Reactome pathway
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| n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck and Co.
Curated by ChEMBL
| Assay Description
Inhibition of human GlyT2 |
Bioorg Med Chem Lett 16: 5968-72 (2006)
Article DOI: 10.1016/j.bmcl.2006.08.131
BindingDB Entry DOI: 10.7270/Q2C82B31 |
More data for this
Ligand-Target Pair | |
Sodium- and chloride-dependent glycine transporter 2
(Homo sapiens (Human)) | BDBM50195170
(2-chloro-N-((4-(morpholine-4-carbonyl)-1-(propylsu...)Show SMILES CCCS(=O)(=O)N1CCC(CNC(=O)c2ccccc2Cl)(CC1)C(=O)N1CCOCC1 Show InChI InChI=1S/C21H30ClN3O5S/c1-2-15-31(28,29)25-9-7-21(8-10-25,20(27)24-11-13-30-14-12-24)16-23-19(26)17-5-3-4-6-18(17)22/h3-6H,2,7-16H2,1H3,(H,23,26) | Reactome pathway
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| n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck and Co.
Curated by ChEMBL
| Assay Description
Inhibition of human GlyT2 |
Bioorg Med Chem Lett 16: 5968-72 (2006)
Article DOI: 10.1016/j.bmcl.2006.08.131
BindingDB Entry DOI: 10.7270/Q2C82B31 |
More data for this
Ligand-Target Pair | |
Sodium- and chloride-dependent glycine transporter 2
(Homo sapiens (Human)) | BDBM50195175
(CHEMBL223491 | N-((4-(3-aminoazetidine-1-carbonyl)...)Show SMILES CCCS(=O)(=O)N1CCC(CNC(=O)c2ccc(Cl)cc2Cl)(CC1)C(=O)N1CC(N)C1 Show InChI InChI=1S/C20H28Cl2N4O4S/c1-2-9-31(29,30)26-7-5-20(6-8-26,19(28)25-11-15(23)12-25)13-24-18(27)16-4-3-14(21)10-17(16)22/h3-4,10,15H,2,5-9,11-13,23H2,1H3,(H,24,27) | Reactome pathway
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| n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck and Co.
Curated by ChEMBL
| Assay Description
Inhibition of human GlyT2 |
Bioorg Med Chem Lett 16: 5968-72 (2006)
Article DOI: 10.1016/j.bmcl.2006.08.131
BindingDB Entry DOI: 10.7270/Q2C82B31 |
More data for this
Ligand-Target Pair | |
Sodium- and chloride-dependent taurine transporter
(Homo sapiens (Human)) | BDBM50195163
(4-((2,4-dichlorobenzamido)methyl)-N,N-dimethyl-1-(...)Show SMILES CCCS(=O)(=O)N1CCC(CNC(=O)c2ccc(Cl)cc2Cl)(CC1)C(=O)N(C)C Show InChI InChI=1S/C19H27Cl2N3O4S/c1-4-11-29(27,28)24-9-7-19(8-10-24,18(26)23(2)3)13-22-17(25)15-6-5-14(20)12-16(15)21/h5-6,12H,4,7-11,13H2,1-3H3,(H,22,25) | Reactome pathway
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| n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck and Co.
Curated by ChEMBL
| Assay Description
Inhibition of human TauT |
Bioorg Med Chem Lett 16: 5968-72 (2006)
Article DOI: 10.1016/j.bmcl.2006.08.131
BindingDB Entry DOI: 10.7270/Q2C82B31 |
More data for this
Ligand-Target Pair | |
Sodium- and chloride-dependent taurine transporter
(Homo sapiens (Human)) | BDBM50195166
(3-chloro-2,6-difluoro-N-((4-(morpholine-4-carbonyl...)Show SMILES CCCS(=O)(=O)N1CCC(CNC(=O)c2c(F)ccc(Cl)c2F)(CC1)C(=O)N1CCOCC1 Show InChI InChI=1S/C21H28ClF2N3O5S/c1-2-13-33(30,31)27-7-5-21(6-8-27,20(29)26-9-11-32-12-10-26)14-25-19(28)17-16(23)4-3-15(22)18(17)24/h3-4H,2,5-14H2,1H3,(H,25,28) | Reactome pathway
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| n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck and Co.
Curated by ChEMBL
| Assay Description
Inhibition of human TauT |
Bioorg Med Chem Lett 16: 5968-72 (2006)
Article DOI: 10.1016/j.bmcl.2006.08.131
BindingDB Entry DOI: 10.7270/Q2C82B31 |
More data for this
Ligand-Target Pair | |
Sodium- and chloride-dependent taurine transporter
(Homo sapiens (Human)) | BDBM50195174
(CHEMBL220948 | N-((4-(morpholine-4-carbonyl)-1-(pr...)Show SMILES CCCS(=O)(=O)N1CCC(CNC(=O)c2ccccc2)(CC1)C(=O)N1CCOCC1 Show InChI InChI=1S/C21H31N3O5S/c1-2-16-30(27,28)24-10-8-21(9-11-24,20(26)23-12-14-29-15-13-23)17-22-19(25)18-6-4-3-5-7-18/h3-7H,2,8-17H2,1H3,(H,22,25) | Reactome pathway
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| n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck and Co.
Curated by ChEMBL
| Assay Description
Inhibition of human TauT |
Bioorg Med Chem Lett 16: 5968-72 (2006)
Article DOI: 10.1016/j.bmcl.2006.08.131
BindingDB Entry DOI: 10.7270/Q2C82B31 |
More data for this
Ligand-Target Pair | |
Sodium- and chloride-dependent taurine transporter
(Homo sapiens (Human)) | BDBM50195164
(CHEMBL220179 | N-((4-(morpholine-4-carbonyl)-1-(pr...)Show SMILES CCCS(=O)(=O)N1CCC(CNC(=O)C2CC2)(CC1)C(=O)N1CCOCC1 Show InChI InChI=1S/C18H31N3O5S/c1-2-13-27(24,25)21-7-5-18(6-8-21,14-19-16(22)15-3-4-15)17(23)20-9-11-26-12-10-20/h15H,2-14H2,1H3,(H,19,22) | Reactome pathway
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| n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck and Co.
Curated by ChEMBL
| Assay Description
Inhibition of human TauT |
Bioorg Med Chem Lett 16: 5968-72 (2006)
Article DOI: 10.1016/j.bmcl.2006.08.131
BindingDB Entry DOI: 10.7270/Q2C82B31 |
More data for this
Ligand-Target Pair | |
Sodium- and chloride-dependent glycine transporter 2
(Homo sapiens (Human)) | BDBM50195167
(4-fluoro-N-((4-(morpholine-4-carbonyl)-1-(propylsu...)Show SMILES CCCS(=O)(=O)N1CCC(CNC(=O)c2ccc(F)cc2C(F)(F)F)(CC1)C(=O)N1CCOCC1 Show InChI InChI=1S/C22H29F4N3O5S/c1-2-13-35(32,33)29-7-5-21(6-8-29,20(31)28-9-11-34-12-10-28)15-27-19(30)17-4-3-16(23)14-18(17)22(24,25)26/h3-4,14H,2,5-13,15H2,1H3,(H,27,30) | Reactome pathway
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| n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck and Co.
Curated by ChEMBL
| Assay Description
Inhibition of human GlyT2 |
Bioorg Med Chem Lett 16: 5968-72 (2006)
Article DOI: 10.1016/j.bmcl.2006.08.131
BindingDB Entry DOI: 10.7270/Q2C82B31 |
More data for this
Ligand-Target Pair | |
Sodium- and chloride-dependent taurine transporter
(Homo sapiens (Human)) | BDBM50195165
(2,4-dichloro-N-((4-(cyclopropanecarbonyl)-1-(propy...)Show SMILES CCCS(=O)(=O)N1CCC(CNC(=O)c2ccc(Cl)cc2Cl)(CC1)C(=O)C1CC1 Show InChI InChI=1S/C20H26Cl2N2O4S/c1-2-11-29(27,28)24-9-7-20(8-10-24,18(25)14-3-4-14)13-23-19(26)16-6-5-15(21)12-17(16)22/h5-6,12,14H,2-4,7-11,13H2,1H3,(H,23,26) | Reactome pathway
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| n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck and Co.
Curated by ChEMBL
| Assay Description
Inhibition of human TauT |
Bioorg Med Chem Lett 16: 5968-72 (2006)
Article DOI: 10.1016/j.bmcl.2006.08.131
BindingDB Entry DOI: 10.7270/Q2C82B31 |
More data for this
Ligand-Target Pair | |
Sodium- and chloride-dependent taurine transporter
(Homo sapiens (Human)) | BDBM50195183
(2,4-dichloro-N-((4-(3-(dimethylamino)pyrrolidine-1...)Show SMILES CCCS(=O)(=O)N1CCC(CNC(=O)c2ccc(Cl)cc2Cl)(CC1)C(=O)N1CCC(C1)N(C)C Show InChI InChI=1S/C23H34Cl2N4O4S/c1-4-13-34(32,33)29-11-8-23(9-12-29,22(31)28-10-7-18(15-28)27(2)3)16-26-21(30)19-6-5-17(24)14-20(19)25/h5-6,14,18H,4,7-13,15-16H2,1-3H3,(H,26,30) | Reactome pathway
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| n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck and Co.
Curated by ChEMBL
| Assay Description
Inhibition of human TauT |
Bioorg Med Chem Lett 16: 5968-72 (2006)
Article DOI: 10.1016/j.bmcl.2006.08.131
BindingDB Entry DOI: 10.7270/Q2C82B31 |
More data for this
Ligand-Target Pair | |
Sodium- and chloride-dependent taurine transporter
(Homo sapiens (Human)) | BDBM50195169
(2,4-dichloro-N-((4-(morpholine-4-carbonyl)-1-(prop...)Show SMILES CCCS(=O)(=O)N1CCC(CNC(=O)c2ccc(Cl)cc2Cl)(CC1)C(=O)N1CCOCC1 Show InChI InChI=1S/C21H29Cl2N3O5S/c1-2-13-32(29,30)26-7-5-21(6-8-26,20(28)25-9-11-31-12-10-25)15-24-19(27)17-4-3-16(22)14-18(17)23/h3-4,14H,2,5-13,15H2,1H3,(H,24,27) | Reactome pathway
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| n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck and Co.
Curated by ChEMBL
| Assay Description
Inhibition of human TauT |
Bioorg Med Chem Lett 16: 5968-72 (2006)
Article DOI: 10.1016/j.bmcl.2006.08.131
BindingDB Entry DOI: 10.7270/Q2C82B31 |
More data for this
Ligand-Target Pair | |
Sodium- and chloride-dependent glycine transporter 2
(Homo sapiens (Human)) | BDBM50195179
(2,6-difluoro-N-((4-(morpholine-4-carbonyl)-1-(prop...)Show SMILES CCCS(=O)(=O)N1CCC(CNC(=O)c2c(F)cccc2F)(CC1)C(=O)N1CCOCC1 Show InChI InChI=1S/C21H29F2N3O5S/c1-2-14-32(29,30)26-8-6-21(7-9-26,20(28)25-10-12-31-13-11-25)15-24-19(27)18-16(22)4-3-5-17(18)23/h3-5H,2,6-15H2,1H3,(H,24,27) | Reactome pathway
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Similars
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| n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck and Co.
Curated by ChEMBL
| Assay Description
Inhibition of human GlyT2 |
Bioorg Med Chem Lett 16: 5968-72 (2006)
Article DOI: 10.1016/j.bmcl.2006.08.131
BindingDB Entry DOI: 10.7270/Q2C82B31 |
More data for this
Ligand-Target Pair | |
Sodium- and chloride-dependent glycine transporter 2
(Homo sapiens (Human)) | BDBM50195183
(2,4-dichloro-N-((4-(3-(dimethylamino)pyrrolidine-1...)Show SMILES CCCS(=O)(=O)N1CCC(CNC(=O)c2ccc(Cl)cc2Cl)(CC1)C(=O)N1CCC(C1)N(C)C Show InChI InChI=1S/C23H34Cl2N4O4S/c1-4-13-34(32,33)29-11-8-23(9-12-29,22(31)28-10-7-18(15-28)27(2)3)16-26-21(30)19-6-5-17(24)14-20(19)25/h5-6,14,18H,4,7-13,15-16H2,1-3H3,(H,26,30) | Reactome pathway
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UniChem
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PubMed
| n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck and Co.
Curated by ChEMBL
| Assay Description
Inhibition of human GlyT2 |
Bioorg Med Chem Lett 16: 5968-72 (2006)
Article DOI: 10.1016/j.bmcl.2006.08.131
BindingDB Entry DOI: 10.7270/Q2C82B31 |
More data for this
Ligand-Target Pair | |
Sodium- and chloride-dependent glycine transporter 2
(Homo sapiens (Human)) | BDBM50195173
(2-chloro-4-fluoro-N-((4-(morpholine-4-carbonyl)-1-...)Show SMILES CCCS(=O)(=O)N1CCC(CNC(=O)c2ccc(F)cc2Cl)(CC1)C(=O)N1CCOCC1 Show InChI InChI=1S/C21H29ClFN3O5S/c1-2-13-32(29,30)26-7-5-21(6-8-26,20(28)25-9-11-31-12-10-25)15-24-19(27)17-4-3-16(23)14-18(17)22/h3-4,14H,2,5-13,15H2,1H3,(H,24,27) | Reactome pathway
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| n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck and Co.
Curated by ChEMBL
| Assay Description
Inhibition of human GlyT2 |
Bioorg Med Chem Lett 16: 5968-72 (2006)
Article DOI: 10.1016/j.bmcl.2006.08.131
BindingDB Entry DOI: 10.7270/Q2C82B31 |
More data for this
Ligand-Target Pair | |
Sodium- and chloride-dependent taurine transporter
(Homo sapiens (Human)) | BDBM50195181
(2,4-dichloro-5-fluoro-N-((4-(morpholine-4-carbonyl...)Show SMILES CCCS(=O)(=O)N1CCC(CNC(=O)c2cc(F)c(Cl)cc2Cl)(CC1)C(=O)N1CCOCC1 Show InChI InChI=1S/C21H28Cl2FN3O5S/c1-2-11-33(30,31)27-5-3-21(4-6-27,20(29)26-7-9-32-10-8-26)14-25-19(28)15-12-18(24)17(23)13-16(15)22/h12-13H,2-11,14H2,1H3,(H,25,28) | Reactome pathway
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| n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck and Co.
Curated by ChEMBL
| Assay Description
Inhibition of human TauT |
Bioorg Med Chem Lett 16: 5968-72 (2006)
Article DOI: 10.1016/j.bmcl.2006.08.131
BindingDB Entry DOI: 10.7270/Q2C82B31 |
More data for this
Ligand-Target Pair | |
Sodium- and chloride-dependent glycine transporter 2
(Homo sapiens (Human)) | BDBM50195174
(CHEMBL220948 | N-((4-(morpholine-4-carbonyl)-1-(pr...)Show SMILES CCCS(=O)(=O)N1CCC(CNC(=O)c2ccccc2)(CC1)C(=O)N1CCOCC1 Show InChI InChI=1S/C21H31N3O5S/c1-2-16-30(27,28)24-10-8-21(9-11-24,20(26)23-12-14-29-15-13-23)17-22-19(25)18-6-4-3-5-7-18/h3-7H,2,8-17H2,1H3,(H,22,25) | Reactome pathway
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| n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck and Co.
Curated by ChEMBL
| Assay Description
Inhibition of human GlyT2 |
Bioorg Med Chem Lett 16: 5968-72 (2006)
Article DOI: 10.1016/j.bmcl.2006.08.131
BindingDB Entry DOI: 10.7270/Q2C82B31 |
More data for this
Ligand-Target Pair | |
Sodium- and chloride-dependent taurine transporter
(Homo sapiens (Human)) | BDBM50195178
(2-chloro-6-fluoro-N-((4-(morpholine-4-carbonyl)-1-...)Show SMILES CCCS(=O)(=O)N1CCC(CNC(=O)c2c(F)cccc2Cl)(CC1)C(=O)N1CCOCC1 Show InChI InChI=1S/C21H29ClFN3O5S/c1-2-14-32(29,30)26-8-6-21(7-9-26,20(28)25-10-12-31-13-11-25)15-24-19(27)18-16(22)4-3-5-17(18)23/h3-5H,2,6-15H2,1H3,(H,24,27) | Reactome pathway
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| n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck and Co.
Curated by ChEMBL
| Assay Description
Inhibition of human TauT |
Bioorg Med Chem Lett 16: 5968-72 (2006)
Article DOI: 10.1016/j.bmcl.2006.08.131
BindingDB Entry DOI: 10.7270/Q2C82B31 |
More data for this
Ligand-Target Pair | |
Sodium- and chloride-dependent glycine transporter 2
(Homo sapiens (Human)) | BDBM50195178
(2-chloro-6-fluoro-N-((4-(morpholine-4-carbonyl)-1-...)Show SMILES CCCS(=O)(=O)N1CCC(CNC(=O)c2c(F)cccc2Cl)(CC1)C(=O)N1CCOCC1 Show InChI InChI=1S/C21H29ClFN3O5S/c1-2-14-32(29,30)26-8-6-21(7-9-26,20(28)25-10-12-31-13-11-25)15-24-19(27)18-16(22)4-3-5-17(18)23/h3-5H,2,6-15H2,1H3,(H,24,27) | Reactome pathway
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| n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck and Co.
Curated by ChEMBL
| Assay Description
Inhibition of human GlyT2 |
Bioorg Med Chem Lett 16: 5968-72 (2006)
Article DOI: 10.1016/j.bmcl.2006.08.131
BindingDB Entry DOI: 10.7270/Q2C82B31 |
More data for this
Ligand-Target Pair | |
Sodium- and chloride-dependent taurine transporter
(Homo sapiens (Human)) | BDBM50195162
(2,4-dichloro-N-((4-(1-methylpiperazine-4-carbonyl)...)Show SMILES CCCS(=O)(=O)N1CCC(CNC(=O)c2ccc(Cl)cc2Cl)(CC1)C(=O)N1CCN(C)CC1 Show InChI InChI=1S/C22H32Cl2N4O4S/c1-3-14-33(31,32)28-8-6-22(7-9-28,21(30)27-12-10-26(2)11-13-27)16-25-20(29)18-5-4-17(23)15-19(18)24/h4-5,15H,3,6-14,16H2,1-2H3,(H,25,29) | Reactome pathway
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| n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck and Co.
Curated by ChEMBL
| Assay Description
Inhibition of human TauT |
Bioorg Med Chem Lett 16: 5968-72 (2006)
Article DOI: 10.1016/j.bmcl.2006.08.131
BindingDB Entry DOI: 10.7270/Q2C82B31 |
More data for this
Ligand-Target Pair | |
Sodium- and chloride-dependent glycine transporter 2
(Homo sapiens (Human)) | BDBM50195171
(4-((2,4-dichlorobenzamido)methyl)-N-((3-methyloxet...)Show SMILES CCCS(=O)(=O)N1CCC(CNC(=O)c2ccc(Cl)cc2Cl)(CC1)C(=O)NCC1(C)COC1 Show InChI InChI=1S/C22H31Cl2N3O5S/c1-3-10-33(30,31)27-8-6-22(7-9-27,20(29)26-12-21(2)14-32-15-21)13-25-19(28)17-5-4-16(23)11-18(17)24/h4-5,11H,3,6-10,12-15H2,1-2H3,(H,25,28)(H,26,29) | Reactome pathway
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| n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck and Co.
Curated by ChEMBL
| Assay Description
Inhibition of human GlyT2 |
Bioorg Med Chem Lett 16: 5968-72 (2006)
Article DOI: 10.1016/j.bmcl.2006.08.131
BindingDB Entry DOI: 10.7270/Q2C82B31 |
More data for this
Ligand-Target Pair | |
Sodium- and chloride-dependent glycine transporter 2
(Homo sapiens (Human)) | BDBM50195164
(CHEMBL220179 | N-((4-(morpholine-4-carbonyl)-1-(pr...)Show SMILES CCCS(=O)(=O)N1CCC(CNC(=O)C2CC2)(CC1)C(=O)N1CCOCC1 Show InChI InChI=1S/C18H31N3O5S/c1-2-13-27(24,25)21-7-5-18(6-8-21,14-19-16(22)15-3-4-15)17(23)20-9-11-26-12-10-20/h15H,2-14H2,1H3,(H,19,22) | Reactome pathway
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| n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck and Co.
Curated by ChEMBL
| Assay Description
Inhibition of human GlyT2 |
Bioorg Med Chem Lett 16: 5968-72 (2006)
Article DOI: 10.1016/j.bmcl.2006.08.131
BindingDB Entry DOI: 10.7270/Q2C82B31 |
More data for this
Ligand-Target Pair | |
Sodium- and chloride-dependent glycine transporter 2
(Homo sapiens (Human)) | BDBM50195172
(CHEMBL220987 | N-((4-(morpholine-4-carbonyl)-1-(pr...)Show SMILES CCCS(=O)(=O)N1CCC(CNC(=O)c2ccccc2OC(F)(F)F)(CC1)C(=O)N1CCOCC1 Show InChI InChI=1S/C22H30F3N3O6S/c1-2-15-35(31,32)28-9-7-21(8-10-28,20(30)27-11-13-33-14-12-27)16-26-19(29)17-5-3-4-6-18(17)34-22(23,24)25/h3-6H,2,7-16H2,1H3,(H,26,29) | Reactome pathway
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| n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck and Co.
Curated by ChEMBL
| Assay Description
Inhibition of human GlyT2 |
Bioorg Med Chem Lett 16: 5968-72 (2006)
Article DOI: 10.1016/j.bmcl.2006.08.131
BindingDB Entry DOI: 10.7270/Q2C82B31 |
More data for this
Ligand-Target Pair | |
Sodium- and chloride-dependent taurine transporter
(Homo sapiens (Human)) | BDBM50195168
(2-fluoro-N-((4-(morpholine-4-carbonyl)-1-(propylsu...)Show SMILES CCCS(=O)(=O)N1CCC(CNC(=O)c2ccc(cc2F)C(F)(F)F)(CC1)C(=O)N1CCOCC1 Show InChI InChI=1S/C22H29F4N3O5S/c1-2-13-35(32,33)29-7-5-21(6-8-29,20(31)28-9-11-34-12-10-28)15-27-19(30)17-4-3-16(14-18(17)23)22(24,25)26/h3-4,14H,2,5-13,15H2,1H3,(H,27,30) | Reactome pathway
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| n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck and Co.
Curated by ChEMBL
| Assay Description
Inhibition of human TauT |
Bioorg Med Chem Lett 16: 5968-72 (2006)
Article DOI: 10.1016/j.bmcl.2006.08.131
BindingDB Entry DOI: 10.7270/Q2C82B31 |
More data for this
Ligand-Target Pair | |
Sodium- and chloride-dependent taurine transporter
(Homo sapiens (Human)) | BDBM50195167
(4-fluoro-N-((4-(morpholine-4-carbonyl)-1-(propylsu...)Show SMILES CCCS(=O)(=O)N1CCC(CNC(=O)c2ccc(F)cc2C(F)(F)F)(CC1)C(=O)N1CCOCC1 Show InChI InChI=1S/C22H29F4N3O5S/c1-2-13-35(32,33)29-7-5-21(6-8-29,20(31)28-9-11-34-12-10-28)15-27-19(30)17-4-3-16(23)14-18(17)22(24,25)26/h3-4,14H,2,5-13,15H2,1H3,(H,27,30) | Reactome pathway
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| n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck and Co.
Curated by ChEMBL
| Assay Description
Inhibition of human TauT |
Bioorg Med Chem Lett 16: 5968-72 (2006)
Article DOI: 10.1016/j.bmcl.2006.08.131
BindingDB Entry DOI: 10.7270/Q2C82B31 |
More data for this
Ligand-Target Pair | |
Sodium- and chloride-dependent glycine transporter 2
(Homo sapiens (Human)) | BDBM50195162
(2,4-dichloro-N-((4-(1-methylpiperazine-4-carbonyl)...)Show SMILES CCCS(=O)(=O)N1CCC(CNC(=O)c2ccc(Cl)cc2Cl)(CC1)C(=O)N1CCN(C)CC1 Show InChI InChI=1S/C22H32Cl2N4O4S/c1-3-14-33(31,32)28-8-6-22(7-9-28,21(30)27-12-10-26(2)11-13-27)16-25-20(29)18-5-4-17(23)15-19(18)24/h4-5,15H,3,6-14,16H2,1-2H3,(H,25,29) | Reactome pathway
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| n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck and Co.
Curated by ChEMBL
| Assay Description
Inhibition of human GlyT2 |
Bioorg Med Chem Lett 16: 5968-72 (2006)
Article DOI: 10.1016/j.bmcl.2006.08.131
BindingDB Entry DOI: 10.7270/Q2C82B31 |
More data for this
Ligand-Target Pair | |
Sodium- and chloride-dependent glycine transporter 2
(Homo sapiens (Human)) | BDBM50195163
(4-((2,4-dichlorobenzamido)methyl)-N,N-dimethyl-1-(...)Show SMILES CCCS(=O)(=O)N1CCC(CNC(=O)c2ccc(Cl)cc2Cl)(CC1)C(=O)N(C)C Show InChI InChI=1S/C19H27Cl2N3O4S/c1-4-11-29(27,28)24-9-7-19(8-10-24,18(26)23(2)3)13-22-17(25)15-6-5-14(20)12-16(15)21/h5-6,12H,4,7-11,13H2,1-3H3,(H,22,25) | Reactome pathway
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| n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck and Co.
Curated by ChEMBL
| Assay Description
Inhibition of human GlyT2 |
Bioorg Med Chem Lett 16: 5968-72 (2006)
Article DOI: 10.1016/j.bmcl.2006.08.131
BindingDB Entry DOI: 10.7270/Q2C82B31 |
More data for this
Ligand-Target Pair | |
Sodium- and chloride-dependent taurine transporter
(Homo sapiens (Human)) | BDBM50195175
(CHEMBL223491 | N-((4-(3-aminoazetidine-1-carbonyl)...)Show SMILES CCCS(=O)(=O)N1CCC(CNC(=O)c2ccc(Cl)cc2Cl)(CC1)C(=O)N1CC(N)C1 Show InChI InChI=1S/C20H28Cl2N4O4S/c1-2-9-31(29,30)26-7-5-20(6-8-26,19(28)25-11-15(23)12-25)13-24-18(27)16-4-3-14(21)10-17(16)22/h3-4,10,15H,2,5-9,11-13,23H2,1H3,(H,24,27) | Reactome pathway
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| n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck and Co.
Curated by ChEMBL
| Assay Description
Inhibition of human TauT |
Bioorg Med Chem Lett 16: 5968-72 (2006)
Article DOI: 10.1016/j.bmcl.2006.08.131
BindingDB Entry DOI: 10.7270/Q2C82B31 |
More data for this
Ligand-Target Pair | |
Sodium- and chloride-dependent glycine transporter 2
(Homo sapiens (Human)) | BDBM50195181
(2,4-dichloro-5-fluoro-N-((4-(morpholine-4-carbonyl...)Show SMILES CCCS(=O)(=O)N1CCC(CNC(=O)c2cc(F)c(Cl)cc2Cl)(CC1)C(=O)N1CCOCC1 Show InChI InChI=1S/C21H28Cl2FN3O5S/c1-2-11-33(30,31)27-5-3-21(4-6-27,20(29)26-7-9-32-10-8-26)14-25-19(28)15-12-18(24)17(23)13-16(15)22/h12-13H,2-11,14H2,1H3,(H,25,28) | Reactome pathway
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| n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck and Co.
Curated by ChEMBL
| Assay Description
Inhibition of human GlyT2 |
Bioorg Med Chem Lett 16: 5968-72 (2006)
Article DOI: 10.1016/j.bmcl.2006.08.131
BindingDB Entry DOI: 10.7270/Q2C82B31 |
More data for this
Ligand-Target Pair | |
Sodium- and chloride-dependent taurine transporter
(Homo sapiens (Human)) | BDBM50195170
(2-chloro-N-((4-(morpholine-4-carbonyl)-1-(propylsu...)Show SMILES CCCS(=O)(=O)N1CCC(CNC(=O)c2ccccc2Cl)(CC1)C(=O)N1CCOCC1 Show InChI InChI=1S/C21H30ClN3O5S/c1-2-15-31(28,29)25-9-7-21(8-10-25,20(27)24-11-13-30-14-12-24)16-23-19(26)17-5-3-4-6-18(17)22/h3-6H,2,7-16H2,1H3,(H,23,26) | Reactome pathway
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| n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck and Co.
Curated by ChEMBL
| Assay Description
Inhibition of human TauT |
Bioorg Med Chem Lett 16: 5968-72 (2006)
Article DOI: 10.1016/j.bmcl.2006.08.131
BindingDB Entry DOI: 10.7270/Q2C82B31 |
More data for this
Ligand-Target Pair | |
Sodium- and chloride-dependent taurine transporter
(Homo sapiens (Human)) | BDBM50195172
(CHEMBL220987 | N-((4-(morpholine-4-carbonyl)-1-(pr...)Show SMILES CCCS(=O)(=O)N1CCC(CNC(=O)c2ccccc2OC(F)(F)F)(CC1)C(=O)N1CCOCC1 Show InChI InChI=1S/C22H30F3N3O6S/c1-2-15-35(31,32)28-9-7-21(8-10-28,20(30)27-11-13-33-14-12-27)16-26-19(29)17-5-3-4-6-18(17)34-22(23,24)25/h3-6H,2,7-16H2,1H3,(H,26,29) | Reactome pathway
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Similars
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| n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck and Co.
Curated by ChEMBL
| Assay Description
Inhibition of human TauT |
Bioorg Med Chem Lett 16: 5968-72 (2006)
Article DOI: 10.1016/j.bmcl.2006.08.131
BindingDB Entry DOI: 10.7270/Q2C82B31 |
More data for this
Ligand-Target Pair | |
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