48 articles for thisTarget

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The following articles (labelled with PubMed ID or TBD) are for your review

PMID	Data	Article Title	Organization
27894870	141	A benzo[b]thiophene-based selective type 4 S1P receptor agonist.	Harvard Medical School
27061986	128	Novel S1P1 receptor agonists - Part 4: Alkylaminomethyl substituted aryl head groups.	Actelion Pharmaceuticals
26751273	92	Discovery of Tetrahydropyrazolopyridine as Sphingosine 1-Phosphate Receptor 3 (S1P3)-Sparing S1P1 Agonists Active at Low Oral Doses.	Glaxosmithkline
26794040	24	Discovery of novel S1P2 antagonists, part 3: Improving the oral bioavailability of a series of 1,3-bis(aryloxy)benzene derivatives.	Ono Pharmaceutical
26384288	29	Discovery of novel S1P2 antagonists. Part 2: Improving the profile of a series of 1,3-bis(aryloxy)benzene derivatives.	Ono Pharmaceutical
25746814	80	Discovery of novel S1P2 antagonists. Part 1: discovery of 1,3-bis(aryloxy)benzene derivatives.	Ono Pharmaceutical
25532755	46	Design and synthesis of new tricyclic indoles as potent modulators of the S1P1 receptor.	Arena Pharmaceuticals
25516794	71	(7-Benzyloxy-2,3-dihydro-1H-pyrrolo[1,2-a]indol-1-yl)acetic Acids as S1P1 Functional Antagonists.	Arena Pharmaceuticals
25516790	37	Discovery of APD334: Design of a Clinical Stage Functional Antagonist of the Sphingosine-1-phosphate-1 Receptor.	Arena Pharmaceuticals
23067318	17	An oral sphingosine 1-phosphate receptor 1 (S1P(1)) antagonist prodrug with efficacy in vivo: discovery, synthesis, and evaluation.	Novartis Pharma
22633692	51	Fused tricyclic indoles as S1P1 agonists with robust efficacy in animal models of autoimmune disease.	Arena Pharmaceuticals
22214363	78	Discovery of a novel class of potent and orally bioavailable sphingosine 1-phosphate receptor 1 antagonists.	Exelixis
24900263	18	4-Methoxy-N-[2-(trifluoromethyl)biphenyl-4-ylcarbamoyl]nicotinamide: A Potent and Selective Agonist of S1P1.	TBA
17379528	30	Synthesis and SAR studies of a novel class of S1P1 receptor antagonists.	Sankyo
15982878	45	Synthesis of 4(5)-phenylimidazole-based analogues of sphingosine-1-phosphate and FTY720: discovery of potent S1P1 receptor agonists.	University Of Virginia
15341948	25	Synthesis of benzimidazole based analogues of sphingosine-1-phosphate: discovery of potent, subtype-selective S1P4 receptor agonists.	University Of Virginia
15341940	109	Design and synthesis of conformationally constrained 3-(N-alkylamino)propylphosphonic acids as potent agonists of sphingosine-1-phosphate (S1P) receptors.	Merck Research Laboratories
15177460	135	The discovery of 3-(N-alkyl)aminopropylphosphonic acids as potent S1P receptor agonists.	Merck Research Laboratories
14505636	51	Synthesis of para-alkyl aryl amide analogues of sphingosine-1-phosphate: discovery of potent S1P receptor agonists.	University Of Virginia
22119341	10	Novel immunomodulators based on an oxazolin-2-one-4-carboxamide scaffold.	Institute Of Pharmacology & Toxicology
21852130	69	Discovery and characterization of potent and selective 4-oxo-4-(5-(5-phenyl-1,2,4-oxadiazol-3-yl)indolin-1-yl)butanoic acids as S1P¿? agonists.	Arena Pharmaceuticals
21982495	61	Discovery, synthesis and SAR analysis of novel selective small molecule S1P4-R agonists based on a (2Z,5Z)-5-((pyrrol-3-yl)methylene)-3-alkyl-2-(alkylimino)thiazolidin-4-one chemotype.	The Scripps Research Institute
21838322	37	Discovery of a brain-penetrant S1P3-sparing direct agonist of the S1P¿? and S1P5 receptors efficacious at low oral dose.	Glaxosmithkline
21783362	17	SAR analysis of innovative selective small molecule antagonists of sphingosine-1-phosphate 4 (S1P4) receptor.	The Scripps Research Institute
21570287	53	Discovery, design and synthesis of the first reported potent and selective sphingosine-1-phosphate 4 (S1P4) receptor antagonists.	The Scripps Research Institute
21295477	24	Structure-activity relationship studies of sphingosine-1-phosphate receptor agonists with N-cinnamyl-ß-alanine moiety.	Ono Pharmaceutical
20446681	158	2-imino-thiazolidin-4-one derivatives as potent, orally active S1P1 receptor agonists.	Actelion Pharmaceuticals
20188554	46	Stereochemistry-activity relationship of orally active tetralin S1P agonist prodrugs.	Biogen Idec
20153186	44	S1P receptor mediated activity of FTY720 phosphate mimics.	Novartis Institutes For Biomedical Research
17113298	45	Synthesis and biological evaluation of gamma-aminophosphonates as potent, subtype-selective sphingosine 1-phosphate receptor agonists and antagonists.	University Of Virginia
16697189	131	Discovery of 3-arylpropionic acids as potent agonists of sphingosine-1-phosphate receptor-1 (S1P1) with high selectivity against all other known S1P receptor subtypes.	Merck Research Laboratories
16621543	59	2-Aryl(pyrrolidin-4-yl)acetic acids are potent agonists of sphingosine-1-phosphate (S1P) receptors.	Merck Research Laboratories
16580205	63	2,5-Disubstituted pyrrolidine carboxylates as potent, orally active sphingosine-1-phosphate (S1P) receptor agonists.	Merck Research Laboratories
16078855	20	Novel immunomodulator FTY720 is phosphorylated in rats and humans to form a single stereoisomer. Identification, chemical proof, and biological characterization of the biologically active species and its enantiomer.	Novartis Institutes For Biomedical Research
15615513	129	A rational utilization of high-throughput screening affords selective, orally bioavailable 1-benzyl-3-carboxyazetidine sphingosine-1-phosphate-1 receptor agonists.	Merck Research Laboratories
15177461	140	Selecting against S1P3 enhances the acute cardiovascular tolerability of 3-(N-benzyl)aminopropylphosphonic acid S1P receptor agonists.	Merck Research Laboratories
15149705	60	Potent S1P receptor agonists replicate the pharmacologic actions of the novel immune modulator FTY720.	Merck Research Laboratories
24824984	55	Identification of Inhibitors of PvdQ, an Enzyme Involved in the Synthesis of the Siderophore Pyoverdine.	The Broad Institute , Cambridge, Massachusetts 02142, United States
3069127	1	Interactive binding between the substrate and allosteric sites of carbamoyl-phosphate synthetase.	Pennsylvania State University