The following articles (labelled with PubMed ID or TBD) are for your review
| PMID | Data | Article Title | Organization |
|---|
| 26988308 |
130 |
N-Alkylpyrido[1',2':1,5]pyrazolo-[4,3-d]pyrimidin-4-amines: A new series of negative allosteric modulators of mGlu1/5 with CNS exposure in rodents. |
Vanderbilt University Medical Center |
| 26814576 |
146 |
New 4-Functionalized Glutamate Analogues Are Selective Agonists at Metabotropic Glutamate Receptor Subtype 2 or Selective Agonists at Metabotropic Glutamate Receptor Group III. |
University of Copenhagen |
| 26426481 |
114 |
Development of Novel, CNS Penetrant Positive Allosteric Modulators for the Metabotropic Glutamate Receptor Subtype 1 (mGlu1), Based on an N-(3-Chloro-4-(1,3-dioxoisoindolin-2-yl)phenyl)-3-methylfuran-2-carboxamide Scaffold, That Potentiate Wild Type and Mutant mGlu1 Receptors Found in Schizophrenics |
Vanderbilt University |
| 26014480 |
87 |
Insights into the interaction of negative allosteric modulators with the metabotropic glutamate receptor 5: discovery and computational modeling of a new series of ligands with nanomolar affinity. |
University of Modena and Reggio Emilia |
| 25958247 |
22 |
Synthesis and studies on the mGluR agonist activity of FAP4 stereoisomers. |
Univ. Rouen |
| 24914612 |
36 |
Tetrahydronaphthyridine and dihydronaphthyridinone ethers as positive allosteric modulators of the metabotropic glutamate receptor 5 (mGlu5). |
Vanderbilt University Medical Center |
| 24735492 |
98 |
Design and synthesis of systemically active metabotropic glutamate subtype-2 and -3 (mGlu2/3) receptor positive allosteric modulators (PAMs): pharmacological characterization and assessment in a rat model of cocaine dependence. |
Sanford-Burnham Medical Research Institute |
| 23357634 |
74 |
Discovery and structure-activity relationship of 1,3-cyclohexyl amide derivatives as novel mGluR5 negative allosteric modulators. |
Lundbeck Research Usa |
| 16337118 |
14 |
From pyrroles to pyrrolo[1,2-a]pyrazinones: a new class of mGluR1 antagonists. |
Glaxosmithkline |
| 23084894 |
56 |
Synthesis and SAR development of novel mGluR1 antagonists for the treatment of chronic pain. |
Merck Research Laboratories |
| 23194448 |
9 |
Development of N-[4-[6-(isopropylamino)pyrimidin-4-yl]-1,3-thiazol-2-yl]-N-methyl-4-[11C]methylbenzamide for positron emission tomography imaging of metabotropic glutamate 1 receptor in monkey brain. |
National Institute of Radiological Sciences |
| 23009245 |
53 |
Orally active metabotropic glutamate subtype 2 receptor positive allosteric modulators: structure-activity relationships and assessment in a rat model of nicotine dependence. |
Sanford-Burnham Medical Research Institute |
| 22316010 |
12 |
Synthesis and evaluation of novel radioligands for positron emission tomography imaging of metabotropic glutamate receptor subtype 1 (mGluR1) in rodent brain. |
National Institute of Radiological Sciences |
| 22386665 |
23 |
3-Phenyl-5-isothiazole carboxamides with potent mGluR1 antagonist activity. |
Eli Lilly |
| 18793851 |
4 |
Positive allosteric modulators of the metabotropic glutamate receptor subtype 4 (mGluR4): Part I. Discovery of pyrazolo[3,4-d]pyrimidines as novel mGluR4 positive allosteric modulators. |
Vanderbilt University Medical Center |
| 18578478 |
60 |
Chemo-enzymatic synthesis of a series of 2,4-syn-functionalized (S)-glutamate analogues: new insight into the structure-activity relation of ionotropic glutamate receptor subtypes 5, 6, and 7. |
Universite Blaise Pascal |
| 18338843 |
57 |
Synthesis and pharmacological characterization at glutamate receptors of the four enantiopure isomers of tricholomic acid. |
Universit£ |
| 18173231 |
71 |
Positive and negative modulation of group I metabotropic glutamate receptors. |
Institute of Organic Synthesis |
| 17350267 |
48 |
Synthesis and preliminary pharmacological evaluation of the four stereoisomers of (2S)-2-(2'-phosphono-3'-phenylcyclopropyl)glycine, the first class of 3'-substituted trans C1'-2'-2-(2'-phosphonocyclopropyl)glycines. |
Universit£ |
| 16213710 |
32 |
Synthesis and preliminary biological evaluation of (2S,1'R,2'S)- and (2S,1'S,2'R)-2-(2'-phosphonocyclopropyl)glycines, two novel conformationally constrained l-AP4 analogues. |
Universit£ |
| 15771457 |
77 |
Synthesis, structure-activity relationship, and receptor pharmacology of a new series of quinoline derivatives acting as selective, noncompetitive mGlu1 antagonists. |
Janssen-Cilag |
| 12109902 |
15 |
Common and selective molecular determinants involved in metabotopic glutamate receptor agonist activity. |
Parc Club Orsay Universit£ |
| 9357538 |
38 |
(S)-homo-AMPA, a specific agonist at the mGlu6 subtype of metabotropic glutamic acid receptors. |
Royal Danish School of Pharmacy |
| 7738999 |
88 |
Metabotropic glutamate receptors: novel targets for drug development. |
Cns Research |
| 11412983 |
9 |
New probes of the agonist binding site of metabotropic glutamate receptors. |
Universit£ |
| 22266036 |
116 |
Fused tricyclic mGluR1 antagonists for the treatment of neuropathic pain. |
Merck Research Laboratories |
| 19433355 |
156 |
Tricyclic thienopyridine-pyrimidones/thienopyrimidine-pyrimidones as orally efficacious mGluR1 antagonists for neuropathic pain. |
Schering-Plough Research Institute |
| 19854049 |
49 |
Discovery and SAR of 6-substituted-4-anilinoquinazolines as non-competitive antagonists of mGlu5. |
Vanderbilt University Medical Center |
| 19692242 |
30 |
Discovery and biological profile of isoindolinone derivatives as novel metabotropic glutamate receptor 1 antagonists: a potential treatment for psychotic disorders. |
Tsukuba Research Institute |
| 19574055 |
82 |
Synergism of virtual screening and medicinal chemistry: identification and optimization of allosteric antagonists of metabotropic glutamate receptor 1. |
Merz Pharmaceuticals |
| | 6 |
Synthesis and biological activity of cyclic analogues of MPPG and MCPG as metabotropic glutamate receptor antagonists |
TBA |
| | 15 |
Synthesis, molecular modeling, and biology of the 1-benzyl derivative of APDC-an apparent mGluR6 selective ligand |
TBA |
| | 10 |
Synthesis and biology of the rigidified glutamate analogue, trans-2-carboxyazetidine-3-acetic acid (t-CAA) |
TBA |
| 19289283 |
34 |
In vitro and in vivo SAR of pyrido[3,4-d]pyramid-4-ylamine based mGluR1 antagonists. |
Medical Research Council Technology |
| 19233648 |
23 |
Fluorinated 9H-xanthene-9-carboxylic acid oxazol-2-yl-amides as potent, orally available mGlu1 receptor enhancers. |
F. Hoffmann-La Roche |
| 17822809 |
46 |
3D-QSAR studies of triazafluorenone inhibitors of metabotropic glutamate receptor subtype 1. |
Biocampus |
| 17929793 |
53 |
Discovery of orally efficacious tetracyclic metabotropic glutamate receptor 1 (mGluR1) antagonists for the treatment of chronic pain. |
Schering-Plough Research Institute |
| 17376693 |
36 |
Novel 5-substituted 1-pyrazolol analogues of ibotenic acid: synthesis and pharmacology at glutamate receptors. |
The Danish University of Pharmaceutical Sciences |
| 17276684 |
26 |
From pyrroles to 1-oxo-2,3,4,9-tetrahydro-1H-beta-carbolines: a new class of orally bioavailable mGluR1 antagonists. |
Glaxosmithkline |
| 17064898 |
32 |
Structure-activity relationships of novel non-competitive mGluR1 antagonists: a potential treatment for chronic pain. |
Pfizer |
| 16828551 |
12 |
Design and synthesis of APTCs (aminopyrrolidinetricarboxylic acids): identification of a new group III metabotropic glutamate receptor selective agonist. |
Faust Pharmaceuticals |
| 16809035 |
15 |
Correlation between brain/plasma ratios and efficacy in neuropathic pain models of selective metabotropic glutamate receptor 1 antagonists. |
Abbott Laboratories |
| 16279797 |
132 |
Structure-activity relationship of triazafluorenone derivatives as potent and selective mGluR1 antagonists. |
Abbott Laboratories |
| 16190758 |
30 |
Synthesis, binding affinity at glutamic acid receptors, neuroprotective effects, and molecular modeling investigation of novel dihydroisoxazole amino acids. |
Università |
| 16078827 |
2 |
A positron emission tomography radioligand for the in vivo labeling of metabotropic glutamate 1 receptor: (3-ethyl-2-[11C]methyl-6-quinolinyl)(cis- 4-methoxycyclohexyl)methanone. |
Columbia University College of Physicians and Surgeons |
| 15317467 |
105 |
Synthesis, in vitro pharmacology, structure-activity relationships, and pharmacokinetics of 3-alkoxy-2-amino-6-fluorobicyclo[3.1.0]hexane-2,6-dicarboxylic acid derivatives as potent and selective group II metabotropic glutamate receptor antagonists. |
Taisho Pharmaceutical |
| 14711315 |
72 |
(2S,1'S,2'R,3'R)-2-(2'-Carboxy-3'-hydroxymethylcyclopropyl) glycine is a highly potent group 2 and 3 metabotropic glutamate receptor agonist with oral activity. |
Eli Lilly |
| 12825948 |
13 |
Synthesis and anticonvulsant activity of novel bicyclic acidic amino acids. |
Università |
| 12798316 |
25 |
2,4-Dicarboxy-pyrroles as selective non-competitive mGluR1 antagonists: further characterization of 3,5-dimethyl pyrrole-2,4-dicarboxylic acid 2-propyl ester 4-(1,2,2-trimethyl-propyl) ester and structure-activity relationships. |
Glaxosmithkline |
| 12213064 |
33 |
Selective agonists at group II metabotropic glutamate receptors: synthesis, stereochemistry, and molecular pharmacology of (S)- and (R)-2-amino-4-(4-hydroxy[1,2,5]thiadiazol-3-yl)butyric acid. |
The Royal Danish School of Pharmacy |
| 11831912 |
43 |
Selective antagonists at group I metabotropic glutamate receptors: synthesis and molecular pharmacology of 4-aryl-3-isoxazolol amino acids. |
The Royal Danish School of Pharmacy |
| 30624919 |
502 |
Evaluation of Amides, Carbamates, Sulfonamides, and Ureas of 4-Prop-2-ynylidenecycloalkylamine as Potent, Selective, and Bioavailable Negative Allosteric Modulators of Metabotropic Glutamate Receptor 5. |
Recordati |
| 10229625 |
16 |
Agonist selectivity of mGluR1 and mGluR2 metabotropic receptors: a different environment but similar recognition of an extended glutamate conformation. |
Parc Club Orsay Université |
| 9873391 |
15 |
Synthesis and pharmacology of N-alkylated derivatives of the excitotoxin ibotenic acid. |
Royal Danish School of Pharmacy |
| 27013388 |
44 |
Re-exploration of the mGlu? PAM Ro 07-11401 scaffold: Discovery of analogs with improved CNS penetration despite steep SAR. |
Vanderbilt University Medical Center |
| 29057060 |
100 |
Discovery of VU6005649, a CNS Penetrant mGlu |
Vanderbilt University |
| 26010139 |
34 |
Synthesis and anticholinergic activity of 4-hydroxycoumarin derivatives containing substituted benzyl-1,2,3-triazole moiety. |
Tehran University of Medical Sciences |
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