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131 articles for thisTarget


The following articles (labelled with PubMed ID or TBD) are for your review
PMIDDataArticle TitleOrganization
28169167 137 Design and synthesis of a novel series of 4-heteroarylamino-1'-azaspiro[oxazole-5,3'-bicyclo[2.2.2]octanes asa7 nicotinic receptor agonists 2. Development of 4-heteroaryl SAR.EBI Bristol-Myers Squibb Pharmaceutical Research Institute
27639361 88 Synthesis and biological evaluation of novel hybrids of highly potent and selectivea4ß2-Nicotinic acetylcholine receptor (nAChR) partial agonists.EBI University of Illinois At Chicago
26706350 48 Modification of the anabaseine pyridine nucleus allows achieving binding and functional selectivity for thea3ß4 nicotinic acetylcholine receptor subtype.EBI Universit£
26383127 13 Design of novel 3,6-diazabicyclo[3.1.1]heptane derivatives with potent and selective affinities fora4ß2 neuronal nicotinic acetylcholine receptors.EBI University of Sassari
26301559 10 Exploration of the molecular architecture of the orthosteric binding site in thea4ß2 nicotinic acetylcholine receptor with analogs of 3-(dimethylamino)butyl dimethylcarbamate (DMABC) and 1-(pyridin-3-yl)-1,4-diazepane.EBI University of Copenhagen
26164842 30 Bifunctional compounds targeting both D2 and non-a7 nACh receptors: design, synthesis and pharmacological characterization.EBI Universit£
26225816 25 Chemistry and Pharmacology of a Series of Unichiral Analogues of 2-(2-Pyrrolidinyl)-1,4-benzodioxane, Prolinol Phenyl Ether, and Prolinol 3-Pyridyl Ether Designed asa4ß2-Nicotinic Acetylcholine Receptor Agonists.EBI Universit£
26142318 36 The twin drug approach for novel nicotinic acetylcholine receptor ligands.EBI University of Hawaii At Hilo
24814197 63 Discovery of novel 2-((pyridin-3-yloxy)methyl)piperazines asa7 nicotinic acetylcholine receptor modulators for the treatment of inflammatory disorders.EBI Critical Therapeutics
24187998 96 Design, synthesis, and biological evaluation of Erythrina alkaloid analogues as neuronal nicotinic acetylcholine receptor antagonists.EBI University of Copenhagen
24050653 59 Derivatives of dibenzothiophene for positron emission tomography imaging ofa7-nicotinic acetylcholine receptors.EBI The Johns Hopkins University School of Medicine
24365158 9 Synthesis and activity of substituted heteroaromatics as positive allosteric modulators fora4ß2a5 nicotinic acetylcholine receptors.EBI The Scripps Research Institute
24200193 32 Characterization of a novela-conotoxin TxID from Conus textile that potently blocks rata3ß4 nicotinic acetylcholine receptors.EBI Hainan University
24156938 12 The 3,7-diazabicyclo[3.3.1]nonane scaffold for subtype selective nicotinic acetylcholine receptor (nAChR) ligands. Part 1: the influence of different hydrogen bond acceptor systems on alkyl and (hetero)aryl substituents.EBI University of Bonn
24047231 52 Design, synthesis and discovery of picomolar selective α4β2 nicotinic acetylcholine receptor ligands.EBI Georgetown University
24128660 6 Design, synthesis and binding affinity of acetylcholine carbamoyl analogues.EBI Universit£
24035337 10 2-Amino-6-chloro-3,4-dihydroquinazoline: A novel 5-HT3 receptor antagonist with antidepressant character.EBI Virginia Commonwealth University
23886687 9 QM-polarized ligand docking accurately predicts the trend in binding affinity of a series of arylmethylene quinuclidine-like derivatives at thea4ß2 anda3ß4 nicotinic acetylcholine receptors (nAChRs).EBI Targacept
23757208 29 Discovery of benzamide analogs as negative allosteric modulators of human neuronal nicotinic receptors: pharmacophore modeling and structure-activity relationship studies.EBI The Ohio State University
23734673 10 Chemistry, pharmacology, and behavioral studies identify chiral cyclopropanes as selectivea4ß2-nicotinic acetylcholine receptor partial agonists exhibiting an antidepressant profile. Part II.EBI University of Illinois At Chicago
23692872 98 Novel nicotinic acetylcholine receptor agonists containing carbonyl moiety as a hydrogen bond acceptor.EBI Targacept
23602445 23 An analysis of the synthetic tryptamines AMT and 5-MeO-DALT: emerging 'Novel Psychoactive Drugs'.EBI Ucl School of Pharmacy
23561269 53 Neonicotinic analogues: selective antagonists fora4ß2 nicotinic acetylcholine receptors.EBI University of Chile
23507153 4 Radiosynthesis and first evaluation in mice of [(18)F]NS14490 for molecular imaging ofa7 nicotinic acetylcholine receptors.EBI Helmholtz-Zentrum Dresden-Rossendorf
23414838 33 Discovery of a novel series of quinolonea7 nicotinic acetylcholine receptor agonists.EBI Bristol-Myers Squibb Pharmaceutical Research Institute
23461628 9 (+)-Laburnamine, a natural selective ligand and partial agonist for the?4?2 nicotinic receptor subtype.EBI Universit£
23540678 26 Chemistry and pharmacological studies of 3-alkoxy-2,5-disubstituted-pyridinyl compounds as novel selectivea4ß2 nicotinic acetylcholine receptor ligands that reduce alcohol intake in rats.EBI Georgetown University Medical Center
23121096 86 Ion channels as therapeutic targets: a drug discovery perspective.EBI Pfizer
23256554 16 Synthesis, pharmacology, and biostructural characterization of novela4ß2 nicotinic acetylcholine receptor agonists.EBI University of Copenhagen
22285942 79 3D-QSAR and 3D-QSSR models of negative allosteric modulators facilitate the design of a novel selective antagonist of humana4ß2 neuronal nicotinic acetylcholine receptors.EBI The Ohio State University
22243960 88 Structure-based design, synthesis and structure-activity relationships of dibenzosuberyl- and benzoate-substituted tropines as ligands for acetylcholine-binding protein.EBI Vu University Amsterdam
22177081 2 Discovery of novela7 nicotinic acetylcholine receptor ligands via pharmacophoric and docking studies of benzylidene anabaseine analogs.EBI Targacept
22060139 21 Structure-activity relationship studies of sulfonylpiperazine analogues as novel negative allosteric modulators of human neuronal nicotinic receptors.EBI The Ohio State University
21905680 26 Deconstruction of thea4ß2 nicotinic acetylcholine receptor positive allosteric modulator desformylflustrabromine.EBI Virginia Commonwealth University
20822184 27 Chemistry and pharmacological characterization of novel nitrogen analogues of AMOP-H-OH (Sazetidine-A, 6-[5-(azetidin-2-ylmethoxy)pyridin-3-yl]hex-5-yn-1-ol) asa4ß2-nicotinic acetylcholine receptor-selective partial agonists.EBI University of Illinois At Chicago
17889526 2 Unique spirocyclopiperazinium salt III: further investigation of monospirocyclopiperazinium (MSPZ) salts as potential analgesics.EBI Peking University
17994682 11 Synthesis and nicotinic acetylcholine receptor binding properties of bridged and fused ring analogues of epibatidine.EBI Research Triangle Institute
17929796 55 Synthesis and structure-activity relationship studies of 3,6-diazabicyclo[3.2.0]heptanes as novel alpha4beta2 nicotinic acetylcholine receptor selective agonists.EBI Neuroscience Research
17585748 31 Structure-activity studies and analgesic efficacy of N-(3-pyridinyl)-bridged bicyclic diamines, exceptionally potent agonists at nicotinic acetylcholine receptors.EBI Abbott Laboratories
17181167 50 Synthesis and structure-activity relationships of 3,8-diazabicyclo[4.2.0]octane ligands, potent nicotinic acetylcholine receptor agonists.EBI Abbott Laboratories
16722642 1 Synthesis and pharmacological characterization of nicotinic acetylcholine receptor properties of (+)- and (-)-pyrido-[3,4-b]homotropanes.EBI Research Triangle Institute
16412637 8 Synthesis and analgesic activity of secondary amine analogues of pyridylmethylamine and positional isomeric analogues of ABT-594.EBI Peking University
16289815 1 A novel nicotinic acetylcholine receptor antagonist radioligand for PET studies.EBI Brookhaven National Laboratory
15686946 36 Halogenated and isosteric cytisine derivatives with increased affinity and functional activity at nicotinic acetylcholine receptors.EBI National Institute of Diabetes and Digestive and Kidney Diseases
15050612 8 alpha4beta2 nACh receptor pharmacophore models.EBI Virginia Commonwealth University
14698195 20 3-(4-Aminobutyn-1-yl)pyridines: binding at alpha 4 beta 2 nicotinic cholinergic receptors.EBI Virginia Commonwealth University
23641311 38 From a4ß2 Nicotinic Ligands to the Discovery of s1 Receptor Ligands: Pharmacophore Analysis and Rational Design.EBI TBA
23126648 213 Discovery of (2S,3R)-N-[2-(Pyridin-3-ylmethyl)-1-azabicyclo[2.2.2]oct-3-yl]benzo[b]furan-2-carboxamide (TC-5619), a selectivea7 nicotinic acetylcholine receptor agonist, for the treatment of cognitive disorders.EBI Targacept
23092294 75 Discovery of highly potent and selectivea4ß2-nicotinic acetylcholine receptor (nAChR) partial agonists containing an isoxazolylpyridine ether scaffold that demonstrate antidepressant-like activity. Part II.EBI University of Illinois At Chicago
23025891 169 Structure-activity studies of 7-heteroaryl-3-azabicyclo[3.3.1]non-6-enes: a novel class of highly potent nicotinic receptor ligands.EBI Targacept
22928944 12 Insights into the structural determinants required for high-affinity binding of chiral cyclopropane-containing ligands toa4ß2-nicotinic acetylcholine receptors: an integrated approach to behaviorally active nicotinic ligands.EBI University of Illinois At Chicago
22793665 190 Discovery of 3-(5-chloro-2-furoyl)-3,7-diazabicyclo[3.3.0]octane (TC-6683, AZD1446), a novel highly selectivea4ß2 nicotinic acetylcholine receptor agonist for the treatment of cognitive disorders.EBI Targacept
21919481 114 Discovery and development ofa7 nicotinic acetylcholine receptor modulators.EBI Targacept
22591063 12 Synthesis and nicotinic receptor activity of chemical space analogues of N-(3R)-1-azabicyclo[2.2.2]oct-3-yl-4-chlorobenzamide (PNU-282,987) and 1,4-diazabicyclo[3.2.2]nonane-4-carboxylic acid 4-bromophenyl ester (SSR180711).EBI University of Berne
22749278 16 Diazaspirocyclic compounds as selective ligands for thea4ß2 nicotinic acetylcholine receptor.EBI Targacept
22171543 22 Chemistry and behavioral studies identify chiral cyclopropanes as selectivea4ß2-nicotinic acetylcholine receptor partial agonists exhibiting an antidepressant profile.EBI University of Illinois At Chicago
24936233 8 Discovery of Novel a4ß2 Neuronal Nicotinic Receptor Modulators through Structure-Based Virtual Screening.EBI TBA
22503453 59 The discovery of 2-fluoro-N-(3-fluoro-4-(5-((4-morpholinobutyl)amino)-1,3,4-oxadiazol-2-yl)phenyl)benzamide, a full agonist of the alpha-7 nicotinic acetylcholine receptor showing efficacy in the novel object recognition model of cognition enhancement.EBI Glaxosmithkline
22503248 61 Identification of a series of 1,3,4-oxadiazol-2-amines as potent alpha-7 agonists with efficacy in the novel object recognition model of cognition.EBI Glaxosmithkline
21058665 52 Nicotinic Acetylcholine Receptor Efficacy and Pharmacological Properties of 3-(Substituted phenyl)-2ß-substituted Tropanes.EBI Research Triangle Institute
20684563 176 Discovery of N-{1-[3-(3-oxo-2,3-dihydrobenzo[1,4]oxazin-4-yl)propyl]piperidin-4-yl}-2-phenylacetamide (Lu AE51090): an allosteric muscarinic M1 receptor agonist with unprecedented selectivity and procognitive potential.EBI H. Lundbeck
20663668 43 A novel series of [3.2.1] azabicyclic biaryl ethers as alpha3beta4 and alpha6/4beta4 nicotinic receptor agonists.EBI Pfizer
19954975 27 Structure-activity relationships of N-substituted ligands for the alpha7 nicotinic acetylcholine receptor.EBI Abbott Laboratories
16934977 16 Epibatidine isomers and analogues: structure-activity relationships.EBI University of Leicester
16765047 23 Aryloxyethylamines: binding at alpha7 nicotinic acetylcholine receptors.EBI Virginia Commonwealth University
16171993 45 3,5-Bicyclic aryl piperidines: a novel class of alpha4beta2 neuronal nicotinic receptor partial agonists for smoking cessation.EBI Pfizer
16033252 84 Neuronal nicotinic acetylcholine receptors: structural revelations, target identifications, and therapeutic inspirations.EBI The Danish University of Pharmaceutical Sciences
15808471 144 2-(Arylmethyl)-3-substituted quinuclidines as selective alpha 7 nicotinic receptor ligands.EBI Targacept
15908213 35 In pursuit of alpha4beta2 nicotinic receptor partial agonists for smoking cessation: carbon analogs of (-)-cytisine.EBI Pfizer
9484491 23 Identification and initial structure-activity relationships of (R)-5-(2-azetidinylmethoxy)-2-chloropyridine (ABT-594), a potent, orally active, non-opiate analgesic agent acting via neuronal nicotinic acetylcholine receptors.EBI Abbott Laboratories
9435889 70 Neuronal nicotinic acetylcholine receptors as targets for drug discovery.EBI Abbott Laboratories
8765504 34 (S)-(-)-5-ethynyl-3-(1-methyl-2-pyrrolidinyl)pyridine maleate (SIB-1508Y): a novel anti-parkinsonian agent with selectivity for neuronal nicotinic acetylcholine receptors.EBI Sibia Neurosciences
15050614 10 Activity of alpha7-selective agonists at nicotinic and serotonin 5HT3 receptors expressed in Xenopus oocytes.EBI University of Florida
15203136 39 (+/-)8-Amino-5,6,7,8-tetrahydroisoquinolines as novel antinociceptive agents.EBI Virginia Commonwealth University
11212100 27 The 5-HT3 antagonist tropisetron (ICS 205-930) is a potent and selective alpha7 nicotinic receptor partial agonist.EBI Astrazeneca
22281189 63 SAR ofa7 nicotinic receptor agonists derived from tilorone: exploration of a novel nicotinic pharmacophore.EBI Abbott Laboratories
22222032 3 Synthesis and binding affinity ata4ß2 anda7 nicotinic acetylcholine receptors of new analogs of epibatidine and epiboxidine containing the 7-azabicyclo[2.2.1]hept-2-ene ring system.EBI Universit£
21905669 9 Discovery of isoxazole analogues of sazetidine-A as selectivea4ß2-nicotinic acetylcholine receptor partial agonists for the treatment of depression.EBI University of Illinois At Chicago
21920761 52 Acetylcholine binding protein (AChBP) as template for hierarchical in silico screening procedures to identify structurally novel ligands for the nicotinic receptors.EBI Vu University Amsterdam
21319801 54 Synthesis of 2-(substituted phenyl)-3,5,5-trimethylmorpholine analogues and their effects on monoamine uptake, nicotinic acetylcholine receptor function, and behavioral effects of nicotine.EBI Research Triangle Institute
21397497 18 Discovery of non-peptide, small molecule antagonists ofa9a10 nicotinic acetylcholine receptors as novel analgesics for the treatment of neuropathic and tonic inflammatory pain.EBI University of Kentucky
21216141 2 Synthesis and structure-analgesic activity relationships of a novel series of monospirocyclopiperazinium salts (MSPZ).EBI Peking University
20681583 7 Novel N-methylated 8-oxoisoguanines from Pacific sponges with diverse neuroactivities.EBI Hokkaido University
20509659 182 Synthesis and characterization of in vitro and in vivo profiles of hydroxybupropion analogues: aids to smoking cessation.EBI Barrow Neurological Institute
20465311 36 Novel alpha-7 nicotinic acetylcholine receptor agonists containing a urea moiety: identification and characterization of the potent, selective, and orally efficacious agonist 1-[6-(4-fluorophenyl)pyridin-3-yl]-3-(4-piperidin-1-ylbutyl) urea (SEN34625/WYE-103914).EBI Siena Biotech
20158204 136 Synthesis and biological evaluation of bupropion analogues as potential pharmacotherapies for smoking cessation.EBI Research Triangle Institute
 11 Novel 2-(2′-furo[3,2-b]pyridinyl) pyrrolidines: potent neuronal nicotinic acetylcholine receptor ligandsEBI TBA
 16 Identification of novel (isoxazole)methylene-1-azabicyclic compounds with high affinity for the central nicotinic cholinergic receptorEBI TBA
17827002 6 Synthesis of poison-frog alkaloids 233A, 235U, and 251AA and their inhibitory effects on neuronal nicotinic acetylcholine receptors.EBI University of Toyama
17604168 3 Synthesis of desformylflustrabromine and its evaluation as an alpha4beta2 and alpha7 nACh receptor modulator.EBI Virginia Commonwealth University
17391965 28 Aporphine metho salts as neuronal nicotinic acetylcholine receptor blockers.EBI University of Chile
15771418 38 Novel pyridyl ring C5 substituted analogues of epibatidine and 3-(1-methyl-2(S)-pyrrolidinylmethoxy)pyridine (A-84543) as highly selective agents for neuronal nicotinic acetylcholine receptors containing beta2 subunits.EBI University of Illinois At Chicago
14684341 15 Synthesis and nicotinic receptor activity of a hydroxylated tropane.EBI University of Wollongong
14611837 18 Synthesis and nicotinic binding of novel phenyl derivatives of UB-165. Identifying factors associated with alpha7 selectivity.EBI University of Bristol
12565964 4 5-Azidoepibatidine: an exceptionally potent photoaffinity ligand for neuronal alpha 4 beta 2 and alpha 7 nicotinic acetylcholine receptors.EBI University of California
12061885 22 Structural features of azidopyridinyl neonicotinoid probes conferring high affinity and selectivity for mammalian alpha4beta2 and Drosophila nicotinic receptors.EBI University of California
32026697 111 Discovery and Development of 3-(6-Chloropyridine-3-yloxymethyl)-2-azabicyclo[3.1.0]hexane Hydrochloride (SUVN-911): A Novel, Potent, Selective, and Orally Active Neuronal Nicotinic Acetylcholine ?4?2 Receptor Antagonist for the Treatment of Depression.EBI Suven Life Sciences
27774124 76 Varying Chirality Across Nicotinic Acetylcholine Receptor Subtypes: Selective Binding of Quinuclidine Triazole Compounds.EBI Mahidol University
30681854 50 New Rigid Nicotine Analogues, Carrying a Norbornane Moiety, Are Potent Agonists of ?7 and ?3* Nicotinic Receptors.EBI University of Florence
31434041 12 Discovery of fused heterocyclic carboxamide derivatives as novel ?7-nAChR agonists: Synthesis, preliminary SAR and biological evaluation.EBI Peking University
10447950 15 Molecular recognition in nicotinic acetylcholine receptors: the importance of pi-cation interactions.EBI Targacept
10377231 2 Synthesis and nicotinic acetylcholine receptor in vivo binding properties of 2-fluoro-3-[2(S)-2-azetidinylmethoxy]pyridine: a new positron emission tomography ligand for nicotinic receptors.EBI Cea
9873508 3 Conformationally restricted analogues of nicotine and anabasine.EBI Sibia Neurosciences
31185168 144 Functionalized 6-(Piperidin-1-yl)-8,9-Diphenyl Purines as Peripherally Restricted Inverse Agonists of the CB1 Receptor.EBI Rti International
31299587 56 Novel N-aryl nicotinamide derivatives: Taking stock on 3,6-diazabicyclo[3.1.1]heptanes as ligands for neuronal acetylcholine receptors.EBI Universit£
31244109 36 Philanthotoxin Analogues That Selectively Inhibit Ganglionic Nicotinic Acetylcholine Receptors with Exceptional Potency.EBI University of Nottingham
9871663 49 Synthesis and structure-activity relationships of pyridine-modified analogs of 3-[2-((S)-pyrrolidinyl)methoxy]pyridine, A-84543, a potent nicotinic acetylcholine receptor agonist.EBI Abbott Laboratories
31271958 53 Bis(het)aryl-1,2,3-triazole quinuclidines as ?7 nicotinic acetylcholine receptor ligands: Synthesis, structure affinity relationships, agonism activity, [EBI Universit£
31401465 52 Multi-target-directed-ligands acting as enzyme inhibitors and receptor ligands.EBI Julius Maximilian University of W£Rzburg
31276409 8 Alkaloids Purified from EBI American University of Health Sciences
26580980 38 Design of ?7 nicotinic acetylcholine receptor ligands using the (het)Aryl-1,2,3-triazole core: Synthesis, in vitro evaluation and SAR studies.EBI Universite Orleans
25147147 101 Identification and pharmacological characterization of 3,6-diazabicyclo[3.1.1]heptane-3-carboxamides as novel ligands for the ?4?2 and ?6/?3?2?3 nicotinic acetylcholine receptors (nAChRs).EBI Targacept
19628399 13 Structural basis for alpha-conotoxin potency and selectivity.EBI Boise State University
30403486 35 Potent Antiglioblastoma Agents by Hybridizing the Onium-Alkyloxy-Stilbene Based Structures of an ?7-nAChR, ?9-nAChR Antagonist and of a Pro-Oxidant Mitocan.EBI Universit£
29671588 35 Absolute Configuration and Pharmacology of the Poison Frog Alkaloid Phantasmidine.EBI Indiana State University
29634269 11 Drimane Sesquiterpenoids Noncompetitively Inhibit Human ?4?2 Nicotinic Acetylcholine Receptors with Higher Potency Compared to Human ?3?4 and ?7 Subtypes.EBI California Northstate University College of Medicine
28606760 57 Progress in the discovery of small molecule modulators of the Cys-loop superfamily receptors.EBI Amgen
29751234 94 Pyridinyl- and pyridazinyl-3,6-diazabicyclo[3.1.1]heptane-anilines: Novel selective ligands with subnanomolar affinity for ?EBI Istituto Di Chimica Biomolecolare
29384668 249 Dual Nicotinic Acetylcholine Receptor ?4?2 Antagonists/?7 Agonists: Synthesis, Docking Studies, and Pharmacological Evaluation of Tetrahydroisoquinolines and Tetrahydroisoquinolinium Salts.EBI University of Copenhagen
27810599 14 From pyrrolidinyl-benzodioxane to pyrrolidinyl-pyridodioxanes, or from unselective antagonism to selective partial agonism at?4?2 nicotinic acetylcholine receptor.EBI Universit£
29094937 194 Structure-Based Design and Discovery of New MEBI University of California
28885019 6 Sulfonium as a Surrogate for Ammonium: A New?7 Nicotinic Acetylcholine Receptor Partial Agonist with Desensitizing Activity.EBI University of Florida
24194515 1 Insights into distinct modulation of a7 and a7ß2 nicotinic acetylcholine receptors by the volatile anesthetic isoflurane.BDB University of Pittsburgh