The following articles (labelled with PubMed ID or TBD) are for your review
| PMID | Data | Article Title | Organization |
|---|
| 6809941 |
88 |
Comparison of the inhibition of Escherichia coli and Lactobacillus casei dihydrofolate reductase by 2,4-diamino-5-(substituted-benzyl)pyrimidines: quantitative structure-activity relationships, X-ray crystallography, and computer graphics in structure-activity analysis. |
TBA |
| 6796688 |
44 |
Comparison of the inhibition of methotrexate-sensitive and -resistant Lactobacillus casei cell cultures with purified Lactobacillus casei dihydrofolate reductase by 4,6-diamino-1,2-dihydro-2,2-dimethyl-1-(3-substituted-phenyl)-s-triazines. Use of quantitative structure-activity relationships in maki |
TBA |
| 25937878 |
9 |
The chemistry and pharmacology of privileged pyrroloquinazolines. |
Oregon Health & Science University |
| 409842 |
24 |
Methotrexate analogues. 9. Synthesis and biological properties of some 8-alkyl-7,8-dihydro analogues. |
TBA |
| 109616 |
9 |
Methotrexate analogues. 12. Synthesis and biological properties of some aza homologues. |
TBA |
| 2502631 |
142 |
On the structure selectivity problem in drug design. A comparative study of benzylpyrimidine inhibition of vertebrate and bacterial dihydrofolate reductase via molecular graphics and quantitative structure-activity relationships. |
Pomona College |
| 6420569 |
189 |
Crystallography, quantitative structure-activity relationships, and molecular graphics in a comparative analysis of the inhibition of dihydrofolate reductase from chicken liver and Lactobacillus casei by 4,6-diamino-1,2-dihydro-2,2-dimethyl-1-(substituted-phenyl)-s-triazine s. |
TBA |
| 6772788 |
8 |
Folate analogues altered in the C9-N10 bridge region. 16. Synthesis and antifolate activity of 11-thiohomoaminopterin. |
TBA |
| 20580561 |
33 |
Pteridine-sulfonamide conjugates as dual inhibitors of carbonic anhydrases and dihydrofolate reductase with potential antitumor activity. |
Instituto Superior T£Cnico |
| 15615538 |
28 |
Synthesis of classical, three-carbon-bridged 5-substituted furo[2,3-d]pyrimidine and 6-substituted pyrrolo[2,3-d]pyrimidine analogues as antifolates. |
Duquesne University |
| 16078850 |
41 |
Synthesis of classical, four-carbon bridged 5-substituted furo[2,3-d]pyrimidine and 6-substituted pyrrolo[2,3-d]pyrimidine analogues as antifolates. |
Duquesne University |
| 12570380 |
34 |
Design, synthesis, and biological activities of classical N-[4-[2-(2-amino-4-ethylpyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-l-glutamic acid and its 6-methyl derivative as potential dual inhibitors of thymidylate synthase and dihydrofolate reductase and as potential antitumor agents. |
Duquesne University |
| 10956221 |
46 |
Effect of C9-methyl substitution and C8-C9 conformational restriction on antifolate and antitumor activity of classical 5-substituted 2,4-diaminofuro[2,3-d]pyrimidines. |
Duquesne University |
| 8201595 |
12 |
Synthesis and antitumor activities of novel 6-5 fused ring heterocycle antifolates: N-[4-[omega-(2-amino-4-substituted-6,7-dihydrocyclopenta [d]pyrimidin-5-yl)alkyl]benzoyl]-L-glutamic acids. |
Eisai |
| 3121855 |
21 |
Synthesis and biological evaluation of 8-deazahomofolic acid and its tetrahydro derivative. |
Sri International |
| 3091832 |
28 |
Folate analogues. 26. Syntheses and antifolate activity of 10-substituted derivatives of 5,8-dideazafolic acid and of the poly-gamma-glutamyl metabolites of N10-propargyl-5,8-dideazafolic acid (PDDF). |
TBA |
| 3100797 |
21 |
Folate analogues. 25. Synthesis and biological evaluation of N10-propargylfolic acid and its reduced derivatives. |
TBA |
| 2423690 |
15 |
Syntheses and antifolate activity of 5-methyl-5-deaza analogues of aminopterin, methotrexate, folic acid, and N10-methylfolic acid. |
TBA |
| 4009615 |
10 |
Synthesis of the antileukemic agents 5,10-dideazaaminopterin and 5,10-dideaza-5,6,7,8-tetrahydroaminopterin. |
TBA |
| 7108907 |
11 |
10-Propargylaminopterin and alkyl homologues of methotrexate as inhibitors of folate metabolism. |
TBA |
| 17569517 |
7 |
Novel boron-containing, nonclassical antifolates: synthesis and preliminary biological and structural evaluation. |
Southern Research Institute |
| 14998335 |
69 |
New 2,4-diamino-5-(2',5'-substituted benzyl)pyrimidines as potential drugs against opportunistic infections of AIDS and other immune disorders. Synthesis and species-dependent antifolate activity. |
Harvard Medical School |
| 9719595 |
120 |
Structure-based design and synthesis of lipophilic 2,4-diamino-6-substituted quinazolines and their evaluation as inhibitors of dihydrofolate reductases and potential antitumor agents. |
Duquesne University |
| 8691474 |
111 |
2,4-diamino-5-deaza-6-substituted pyrido[2,3-d]pyrimidine antifolates as potent and selective nonclassical inhibitors of dihydrofolate reductases. |
Duquesne University |
| 8230134 |
48 |
Synthesis of 5-methyl-5-deaza nonclassical antifolates as inhibitors of dihydrofolate reductases and as potential antipneumocystis, antitoxoplasma, and antitumor agents. |
Duquesne University |
| 8230096 |
79 |
2,4-Diaminothieno[2,3-d]pyrimidine analogues of trimetrexate and piritrexim as potential inhibitors of Pneumocystis carinii and Toxoplasma gondii dihydrofolate reductase. |
Harvard Medical School |
| 8164259 |
44 |
Classical and nonclassical furo[2,3-d]pyrimidines as novel antifolates: synthesis and biological activities. |
Duquesne University |
| 7752201 |
68 |
6-substituted 2,4-diamino-5-methylpyrido[2,3-d]pyrimidines as inhibitors of dihydrofolate reductases from Pneumocystis carinii and Toxoplasma gondii and as antitumor agents. |
Duquesne University |
| 7562910 |
18 |
Effect of bridge region variation on antifolate and antitumor activity of classical 5-substituted 2,4-diaminofuro[2,3-d]pyrimidines. |
Duquesne University |
| 7490723 |
37 |
New drug developments for opportunistic infections in immunosuppressed patients: Pneumocystis carinii. |
Indiana University School of Medicine |
| 7473577 |
11 |
5-Arylthio-substituted 2-amino-4-oxo-6-methylpyrrolo[2,3-d]pyrimidine antifolates as thymidylate synthase inhibitors and antitumor agents. |
Duquesne University |
| 6793726 |
7 |
Folate analogues altered in the C9-N10 bridge region. 18. Synthesis and antitumor evaluation of 11-oxahomoaminopterin and related compounds. |
TBA |
| 6438320 |
10 |
A 1H NMR study of the interactions and conformations of rationally designed brodimoprim analogues in complexes with Lactobacillus casei dihydrofolate reductase. |
TBA |
| 6403710 |
6 |
Folate analogues. 21. Synthesis and antifolate and antitumor activities of N10-(cyanomethyl)-5,8-dideazafolic acid. |
TBA |
| 9784101 |
32 |
Quantitative structure-activity relationships of 2, 4-diamino-5-(2-X-benzyl)pyrimidines versus bacterial and avian dihydrofolate reductase. |
University of California |
| 3712374 |
25 |
Synthesis and biological activity of resolved C-10 diastereomers of 10-methyl- and 10-ethyl-10-deazaminopterin. |
TBA |
| 3599032 |
22 |
Folate analogues. 30. Synthesis and biological evaluation of N10-propargyl-5,8-dideaza-5,6,7,8-tetrahydrofolic acid and related compounds. |
TBA |
| 3184124 |
28 |
Synthesis and antifolate activity of 5-methyl-5,10-dideaza analogues of aminopterin and folic acid and an alternative synthesis of 5,10-dideazatetrahydrofolic acid, a potent inhibitor of glycinamide ribonucleotide formyltransferase. |
Southern Research Institute |
| 3091834 |
6 |
Synthesis and antifolate properties of 5,10-methylenetetrahydro-8,10-dideazaminopterin. |
TBA |
| 2542557 |
14 |
Folate analogues. 32. Synthesis and biological evaluation of 2-desamino-2-methyl-N10-propargyl-5,8-dideazafolic acid and related compounds. |
University of South Alabama |
| 2447278 |
17 |
Synthesis and biological evaluation of poly-gamma-glutamyl metabolites of 10-deazaaminopterin and 10-ethyl-10-deazaaminopterin. |
University of South Alabama |
| 1995868 |
4 |
The renewed potential for folate antagonists in contemporary cancer chemotherapy. |
Parke-Davis Pharmaceutical Research Division |
| 1433179 |
13 |
5,10-Methylenetetrahydro-5-deazafolic acid and analogues: synthesis and biological activities. |
Duquesne University |
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