The following articles (labelled with PubMed ID or TBD) are for your review
| PMID | Data | Article Title | Organization |
|---|
| 8360878 |
29 |
Quinoxaline N-oxide containing potent angiotensin II receptor antagonists: synthesis, biological properties, and structure-activity relationships. |
Bristol-Myers Squibb Pharmaceutical Research Institute |
| 8360871 |
86 |
Nonpeptide angiotensin II receptor antagonists. 2. Design, synthesis, and structure-activity relationships of 2-alkyl-4-(1H-pyrrol-1-yl)-1H-imidazole derivatives: profile of 2-propyl-1-[[2'-(1H-tetrazol-5-yl)-[1,1' -biphenyl]-4-yl]-methyl]-4-[2-(trifluoroacetyl)-1H-pyrrol-1-yl]-1H- imidazole-5-car |
Warner-Lambert |
| 8515425 |
65 |
Potent nonpeptide angiotensin II receptor antagonists. 2. 1-(Carboxybenzyl)imidazole-5-acrylic acids. |
Smithkline Beecham Pharmaceuticals |
| 1875338 |
7 |
Conformationally restricted polysubstituted biphenyl derivatives with angiotensin II receptors antagonist properties. |
Searle R & D and Mcr |
| 1875348 |
65 |
Nonpeptide angiotensin II receptor antagonists: the discovery of a series of N-(biphenylylmethyl)imidazoles as potent, orally active antihypertensives. |
E. I. Du Pont De Nemours |
| 1956044 |
115 |
Synthesis and structure-activity relationships of a novel series of non-peptide angiotensin II receptor binding inhibitors specific for the AT2 subtype. |
Warner-Lambert |
| 2329554 |
20 |
Nonpeptide angiotensin II receptor antagonists: N-[(benzyloxy)benzyl]imidazoles and related compounds as potent antihypertensives. |
E. I. Du Pont De Nemours And |
| 2329553 |
81 |
The discovery of potent nonpeptide angiotensin II receptor antagonists: a new class of potent antihypertensives. |
E. I. Du Pont De Nemours |
| 2704034 |
16 |
Topographic probes of angiotensin and receptor: potent angiotensin II agonist containing diphenylalanine and long-acting antagonists containing biphenylalanine and 2-indan amino acid in position 8. |
Washington State University |
| 16220978 |
14 |
Angiotensin II pseudopeptides containing 1,3,5-trisubstituted benzene scaffolds with high AT2 receptor affinity. |
Uppsala University |
| 11960488 |
3 |
Vinyl sulfide cyclized analogues of angiotensin II with high affinity and full agonist activity at the AT(1) receptor. |
Uppsala University |
| 1469703 |
14 |
Dihydropyrimidine angiotensin II receptor antagonists. |
Bristol-Myers Squibb Pharmaceutical Research Institute |
| | 17 |
1,4-substituted indoles: a potent and selective class of angiostensin II receptor antagonists |
TBA |
| | 8 |
Acyliminothiadiazoline derivatives: New, highly potent, and orally active angiotensin II receptor antagonists |
TBA |
| | 54 |
4,5-Dihydro-4-oxo-3H-imidazo[4,5-c]pyridines: potent arylacetic acid-derived AT1 antagonists with improved affinity for the AT2 receptor |
TBA |
| | 42 |
Balanced AT1 and AT2 angiotensin II antagonists. II. Potent 5 α-hydroxyacid imidazolyl biphenyl sulfonylureas |
TBA |
| | 31 |
Uracil-based angiotensin II receptor antagonists |
TBA |
| | 60 |
The SAR of 6-(N-alkyl-N-acyl)-2-propyl-3-[(2′-tetrazol-5-yl)biphen-4-yl)methyl]-quinazolinones as balanced affinity antagonists of the human AT1 and AT2 receptors |
TBA |
| | 19 |
2,3,6-Substituted quinazolinones as angiotensin II receptor antagonists |
TBA |
| | 56 |
Potent triazolinone-based angiotensin II receptor antagonists with equivalent affinity for both the AT1 and AT2 subtypes |
TBA |
| | 24 |
Discovery of nonpeptide potent conformationally restricted angiotensin II receptor antagonists |
TBA |
| | 134 |
Development of angiotensin II antagonists with equipotent affinity for human AT1 and AT2 receptor subtypes. |
TBA |
| | 46 |
Balanced angiotensin II receptor antagonists. I. The effects of biphenyl “ortho”-substitution on AT1/AT2 affinities |
TBA |
| | 10 |
Synthesis and biological evaluation of the potent isoxazolidinyl angiotensin II receptor antagonist CL332,877 and its enantiomers. |
TBA |
| | 34 |
6-isoxazolinyl and isoxazolidinyl substituted quinazolinones as angiotensin II receptor antagonists |
TBA |
| | 12 |
A potent long-acting imidazole-5-acrylic acid angiotensin II AT-1 receptor antagonist |
TBA |
| | 1 |
Orally active prodrugs of quinoline-4-carboxylic acid angiotensin II receptor antagonists |
TBA |
| | 12 |
Quinoline-4-carboxylic acids as angiotensin II receptor antagonists |
TBA |
| | 16 |
Dihydro-imidazolone derivatives as angiotensin II receptor antagonists: chiral effect on the activity |
TBA |
| | 6 |
Cyclopentanespiro-3H-dihydro-pyrimidinones as Angiotensin II AT1 receptor antagonists |
TBA |
| | 19 |
Triazolinones as nonpeptide angiotensin II antagonists. 2. discovery of a potent and orally active triazolinone acylsulfonamide |
TBA |
| 15115399 |
41 |
Design, synthesis, structural studies, biological evaluation, and computational simulations of novel potent AT(1) angiotensin II receptor antagonists based on the 4-phenylquinoline structure. |
Università |
| 12643919 |
50 |
Discovery of 4'-[(imidazol-1-yl)methyl]biphenyl-2-sulfonamides as dual endothelin/angiotensin II receptor antagonists. |
Bristol-Myers Squibb Pharmaceutical Research Institute |
| 12190306 |
14 |
Discovery of N-isoxazolyl biphenylsulfonamides as potent dual angiotensin II and endothelin A receptor antagonists. |
Bristol-Myers Squibb Pharmaceutical Research Institute |
| 8515427 |
43 |
Multiple binding modes for the receptor-bound conformations of cyclic AII agonists. |
Washington University |
| 8510101 |
37 |
Nonpeptide angiotensin II receptor antagonists. 1. Synthesis and in vitro structure-activity relationships of 4-[[[(1H-pyrrol-1-ylacetyl)amino]phenyl]methyl]imidazole derivatives as angiotensin II receptor antagonists. |
Warner-Lambert |
| 8496939 |
100 |
Nonpeptide angiotensin II antagonists derived from 4H-1,2,4-triazoles and 3H-imidazo[1,2-b][1,2,4]triazoles. |
Merck Research Laboratories |
| 8421274 |
27 |
Nonpeptide angiotensin II antagonists: N-phenyl-1H-pyrrole derivatives are angiotensin II receptor antagonists. |
Searle |
| 8340920 |
43 |
Synthesis and structure-activity relationships of nonpeptide, potent triazolone-based angiotensin II receptor antagonists. |
Searle R&D |
| 8258826 |
42 |
6-Substituted benzimidazoles as new nonpeptide angiotensin II receptor antagonists: synthesis, biological activity, and structure-activity relationships. |
Dr. Karl Thomae |
| 8258820 |
47 |
A novel series of selective, non-peptide inhibitors of angiotensin II binding to the AT2 site. |
Dupont Pharmaceuticals |
| 8230127 |
52 |
A new series of imidazolones: highly specific and potent nonpeptide AT1 angiotensin II receptor antagonists. |
Sanofi Recherche |
| 8201597 |
10 |
Non-peptide angiotensin II receptor antagonists: synthesis and biological activity of a series of novel 4,5-dihydro-4-oxo-3H-imidazo[4,5-c]pyridine derivatives. |
E. Merck |
| 8057285 |
44 |
Synthesis and SAR studies of novel triazolopyrimidine derivatives as potent, orally active angiotensin II receptor antagonists. |
Carpibem |
| 12593652 |
50 |
Non-peptide angiotensin II receptor antagonists: chemical feature based pharmacophore identification. |
University of Innsbruck |
| 10052967 |
2 |
Bicyclic tripeptide mimetics with reverse turn inducing properties. |
Uppsala University |
| 10579816 |
10 |
Angiotensin II analogues encompassing 5,9- and 5,10-fused thiazabicycloalkane tripeptide mimetics. |
Uppsala University |
| 9784100 |
5 |
Metabolites of the angiotensin II antagonist tasosartan: the importance of a second acidic group. |
Wyeth-Ayerst Research |
| 9083479 |
15 |
Design, synthesis, and biological activities of four angiotensin II receptor ligands with gamma-turn mimetics replacing amino acid residues 3-5. |
Uppsala University |
| 7473594 |
11 |
4-(Heteroarylthio)-2-biphenylyltetrazoles as nonpeptide angiotensin II antagonists. |
Burroughs Wellcome |
| 7636853 |
35 |
4-Diazinyl- and 4-pyridinylimidazoles: potent angiotensin II antagonists. A study of their activity and computational characterization. |
Laboratori Guidotti |
| 7608902 |
53 |
Sulfonylureas and sulfonylcarbamates as new non-tetrazole angiotensin II receptor antagonists. Discovery of a highly potent orally active (imidazolylbiphenylyl)sulfonylurea (HR 720). |
Hoechst Roussel Pgu Cardiovascular Agents |
| 8120871 |
19 |
Pyrido[2,3-d]pyrimidine angiotensin II antagonists. |
Wyeth-Ayerst Research |
| 7966154 |
15 |
Nonpeptide angiotensin II receptor antagonists. Synthesis, in vitro activity, and molecular modeling studies of N-[(heterobiaryl)methyl] imidazoles. |
Istituto Lusofarmaco |
| 7932534 |
29 |
Bromobenzofuran-based non-peptide antagonists of angiotensin II: GR138950, a potent antihypertensive agent with high oral bioavailability. |
Glaxo Research and Development |
| 2362273 |
16 |
Conformational restriction of angiotensin II: cyclic analogues having high potency. |
G.D. Searle And |
| 1920360 |
13 |
Nonpeptidic angiotensin II antagonists: synthesis and in vitro activity of a series of novel naphthalene and tetrahydronaphthalene derivatives. |
Ciba-Geigy |
| 1635064 |
8 |
Nonpeptide angiotensin II receptor antagonists: synthetic and computational chemistry of N-[[4-[2-(2H-tetrazol-5-yl)-1-cycloalken-1- yl]phenyl]methyl]imidazole derivatives and their in vitro activity. |
Eli Lilly |
| 1433195 |
55 |
Imidazole-5-acrylic acids: potent nonpeptide angiotensin II receptor antagonists designed using a novel peptide pharmacophore model. |
Smithkline Beecham Pharmaceuticals |
| 1433184 |
7 |
Discovery of a novel class of orally active, non-peptide angiotensin II antagonists. |
Abbott Laboratories |
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