The following articles (labelled with PubMed ID or TBD) are for your review
| PMID | Data | Article Title | Organization |
|---|
| 28603989 |
53 |
a-Conotoxin [S9A]TxID Potently Discriminates betweena3ß4 anda6/a3ß4 Nicotinic Acetylcholine Receptors. |
Hainan University |
| 28337332 |
41 |
BMS-933043, a Selectivea7 nAChR Partial Agonist for the Treatment of Cognitive Deficits Associated with Schizophrenia. |
Bristol-Myers Squibb |
| 27958732 |
93 |
Design and Synthesis of a New Series of 4-Heteroarylamino-1'-azaspiro[oxazole-5,3'-bicyclo[2.2.2]octanes asa7 Nicotinic Receptor Agonists. 1. Development of Pharmacophore and Early Structure-Activity Relationship. |
Bristol-Myers Squibb |
| 27639361 |
88 |
Synthesis and biological evaluation of novel hybrids of highly potent and selectivea4ß2-Nicotinic acetylcholine receptor (nAChR) partial agonists. |
University of Illinois At Chicago |
| 27818109 |
30 |
Novel 5-substituted 3-hydroxyphenyl and 3-nitrophenyl ethers of S-prolinol asa4ß2-nicotinic acetylcholine receptor ligands. |
Universit£ |
| 26706350 |
48 |
Modification of the anabaseine pyridine nucleus allows achieving binding and functional selectivity for thea3ß4 nicotinic acetylcholine receptor subtype. |
Universit£ |
| 24844195 |
21 |
Synthesis and pharmacological characterization of new neuronal nicotinic acetylcholine receptor ligands derived from Sazetidine-A. |
Georgetown University Medical Center |
| 24942641 |
7 |
Molecular basis of the selective binding of MDMA enantiomers to the alpha4beta2 nicotinic receptor subtype: synthesis, pharmacological evaluation and mechanistic studies. |
University of Barcelona |
| 24187998 |
96 |
Design, synthesis, and biological evaluation of Erythrina alkaloid analogues as neuronal nicotinic acetylcholine receptor antagonists. |
University of Copenhagen |
| 24649848 |
47 |
Discovery of a potent and selectivea3ß4 nicotinic acetylcholine receptor antagonist from ana-conotoxin synthetic combinatorial library. |
Torrey Pines Institute For Molecular Studies |
| 9513595 |
2 |
Mono- and disubstituted-3,8-diazabicyclo[3.2.1]octane derivatives as analgesics structurally related to epibatidine: synthesis, activity, and modeling. |
Universit£ |
| 9733494 |
12 |
2-, 5-, and 6-Halo-3-(2(S)-azetidinylmethoxy)pyridines: synthesis, affinity for nicotinic acetylcholine receptors, and molecular modeling. |
National Institute On Drug Abuse |
| 15050617 |
5 |
Subtype-selective nicotinic receptor antagonists: potential as tobacco use cessation agents. |
University of Kentucky |
| 15050615 |
36 |
Synthesis and pharmacological characterization of bivalent ligands of epibatidine at neuronal nicotinic acetylcholine receptors. |
University of Illinois At Chicago |
| 12639569 |
23 |
Binding of nicotine and homoazanicotine analogues at neuronal nicotinic acetylcholinergic (nACh) receptors. |
Virginia Commonwealth University |
| 12729652 |
1 |
Unique spirocyclopiperazinium salt. Part 2: synthesis and structure-activity relationship of dispirocyclopiperazinium salts as analgesics. |
Peking University |
| 9873625 |
45 |
Structure-activity studies related to ABT-594, a potent nonopioid analgesic agent: effect of pyridine and azetidine ring substitutions on nicotinic acetylcholine receptor binding affinity and analgesic activity in mice. |
Abbott Laboratories |
| 23121096 |
86 |
Ion channels as therapeutic targets: a drug discovery perspective. |
Pfizer |
| 11405659 |
22 |
Synthesis, nicotinic acetylcholine receptor binding, and antinociceptive properties of 2-exo-2-(2'-substituted 5'-pyridinyl)-7-azabicyclo[2.2.1]heptanes. Epibatidine analogues. |
Research Triangle Institute |
| 10841800 |
4 |
Novel potent ligands for the central nicotinic acetylcholine receptor: synthesis, receptor binding, and 3D-QSAR analysis. |
Neurosearch |
| 12643898 |
4 |
Syntheses and biological properties of cysteine-reactive epibatidine derivatives. |
Universit£ |
| 10843217 |
24 |
Synthesis and structure-activity relationship of novel pyridyl ethers for the nicotinic acetylcholine receptor. |
R. W. Johnson Pharmaceutical Research Institute |
| 23641311 |
38 |
From a4ß2 Nicotinic Ligands to the Discovery of s1 Receptor Ligands: Pharmacophore Analysis and Rational Design. |
TBA |
| 22410083 |
17 |
Consequences of linker length alteration of thea7 nicotinic acetylcholine receptor (nAChR) agonist, SEN12333. |
The University of Sydney |
| 19954975 |
27 |
Structure-activity relationships of N-substituted ligands for the alpha7 nicotinic acetylcholine receptor. |
Abbott Laboratories |
| 15715488 |
21 |
Synthesis, nicotinic acetylcholine receptor binding, and antinociceptive properties of 3'-substituted deschloroepibatidine analogues. Novel nicotinic antagonists. |
Research Triangle Institute |
| 11855986 |
24 |
Synthesis and nicotinic binding studies on enantiopure diazine analogues of the novel (2-chloro-5-pyridyl)-9-azabicyclo[4.2.1]non-2-ene UB-165. |
Institut F£R Pharmazeutische Chemie Der Philipps-Universit£T Marburg |
| 9622546 |
109 |
6beta-Acetoxynortropane: a potent muscarinic agonist with apparent selectivity toward M2-receptors. |
National Institute of Diabetes and Digestive and Kidney Diseases |
| 9435889 |
70 |
Neuronal nicotinic acetylcholine receptors as targets for drug discovery. |
Abbott Laboratories |
| 15050613 |
50 |
Pharmacology of the agonist binding sites of rat neuronal nicotinic receptor subtypes expressed in HEK 293 cells. |
Georgetown University School of Medicine |
| 12467625 |
32 |
N,N-disubstituted piperazines: synthesis and affinities at alpha4beta2(*) and alpha7(*) neuronal nicotinic acetylcholine receptors. |
Chinese Academy of Sciences |
| 12372503 |
76 |
bis-Azaaromatic quaternary ammonium analogues: ligands for alpha4beta2* and alpha7* subtypes of neuronal nicotinic receptors. |
University of Kentucky |
| 20932609 |
26 |
Synthesis of novel chiral¿2-isoxazoline derivatives related to ABT-418 and estimation of their affinity at neuronal nicotinic acetylcholine receptor subtypes. |
Universit£ |
| 20979364 |
40 |
Novela3ß4 nicotinic acetylcholine receptor-selective ligands. Discovery, structure-activity studies, and pharmacological evaluation. |
Sri International |
| 20880707 |
13 |
Identification of 9-fluoro substituted (-)-cytisine derivatives as ligands with high affinity for nicotinic receptors. |
Ensicaen-Université |
| 20236734 |
186 |
A computational study of the binding of 3-(arylidene) anabaseines to two major brain nicotinic acetylcholine receptors and to the acetylcholine binding protein. |
University of Florida |
| 20472430 |
114 |
Syntheses and structure-activity relationship (SAR) studies of 2,5-diazabicyclo[2.2.1]heptanes as novel alpha7 neuronal nicotinic receptor (NNR) ligands. |
Abbott Laboratories |
| 20038125 |
28 |
Synthesis, nicotinic acetylcholine receptor binding, and antinociceptive properties of 3'-(substituted phenyl)epibatidine analogues. Nicotinic partial agonists. |
Research Triangle Institute |
| | 18 |
Corrigendum to Epibatidine structureactivity relationships |
TBA |
| 17850058 |
19 |
Design, synthesis, and preliminary pharmacological evaluation of new quinoline derivatives as nicotinic ligands. |
University of Florence |
| 16905316 |
42 |
Des-keto lobeline analogs with increased potency and selectivity at dopamine and serotonin transporters. |
University of Kentucky |
| 16005216 |
20 |
The characterization of a novel rigid nicotine analog with alpha7-selective nAChR agonist activity and modulation of agonist properties by boron inclusion. |
University of Florida |
| 15771418 |
38 |
Novel pyridyl ring C5 substituted analogues of epibatidine and 3-(1-methyl-2(S)-pyrrolidinylmethoxy)pyridine (A-84543) as highly selective agents for neuronal nicotinic acetylcholine receptors containing beta2 subunits. |
University of Illinois At Chicago |
| 15501049 |
18 |
Synthesis and alpha4beta2 nicotinic affinity of 2-pyrrolidinylmethoxyimines and prolinal oxime ethers. |
Università |
| 15050621 |
100 |
Epibatidine structure-activity relationships. |
Research Triangle Institute |
| 15050618 |
32 |
Development of subtype-selective ligands as antagonists at nicotinic receptors mediating nicotine-evoked dopamine release. |
University of Kentucky |
| 14611837 |
18 |
Synthesis and nicotinic binding of novel phenyl derivatives of UB-165. Identifying factors associated with alpha7 selectivity. |
University of Bristol |
| 12061886 |
11 |
Synthesis and evaluation of a novel series of 2-chloro-5-((1-methyl-2-(S)-pyrrolidinyl)methoxy)-3-(2-(4-pyridinyl)vinyl)pyridine analogues as potential positron emission tomography imaging agents for nicotinic acetylcholine receptors. |
National Institute On Drug Abuse |
| 11266158 |
29 |
Synthesis and structure-activity relationships of 5-substituted pyridine analogues of 3. |
Abbott Laboratories |
| 32026697 |
111 |
Discovery and Development of 3-(6-Chloropyridine-3-yloxymethyl)-2-azabicyclo[3.1.0]hexane Hydrochloride (SUVN-911): A Novel, Potent, Selective, and Orally Active Neuronal Nicotinic Acetylcholine ?4?2 Receptor Antagonist for the Treatment of Depression. |
Suven Life Sciences |
| 11063601 |
29 |
(-)-Spiro[1-azabicyclo[2.2.2]octane-3,5'-oxazolidin-2'-one], a conformationally restricted analogue of acetylcholine, is a highly selective full agonist at the alpha 7 nicotinic acetylcholine receptor. |
Astrazeneca R&D Boston |
| 27774124 |
76 |
Varying Chirality Across Nicotinic Acetylcholine Receptor Subtypes: Selective Binding of Quinuclidine Triazole Compounds. |
Mahidol University |
| 10509928 |
31 |
Structure-activity studies on a novel series of cholinergic channel activators based on a heteroaryl ether framework. |
Abbott Laboratories |
| 31986036 |
89 |
Structure and Activity Studies of Disulfide-Deficient Analogues of ?O-Conotoxin GeXIVA. |
Hainan University |
| 31194549 |
57 |
PeIA-5466: A Novel Peptide Antagonist Containing Non-natural Amino Acids That Selectively Targets ?3?2 Nicotinic Acetylcholine Receptors. |
Veterans Affairs Medical Center |
| 31299587 |
56 |
Novel N-aryl nicotinamide derivatives: Taking stock on 3,6-diazabicyclo[3.1.1]heptanes as ligands for neuronal acetylcholine receptors. |
Universit£ |
| 9871663 |
49 |
Synthesis and structure-activity relationships of pyridine-modified analogs of 3-[2-((S)-pyrrolidinyl)methoxy]pyridine, A-84543, a potent nicotinic acetylcholine receptor agonist. |
Abbott Laboratories |
| 26298493 |
133 |
Conformationally restrained carbamoylcholine homologues. Synthesis, pharmacology at neuronal nicotinic acetylcholine receptors and biostructural considerations. |
Iqm-Csic |
| 25050162 |
78 |
Synthesis and Pharmacological Evaluation of DH?E Analogues as Neuronal Nicotinic Acetylcholine Receptor Antagonists. |
University of Copenhagen |
| 24145137 |
90 |
The 3,7-diazabicyclo[3.3.1]nonane scaffold for subtype selective nicotinic acetylcholine receptor ligands. Part 2: carboxamide derivatives with different spacer motifs. |
University of Bonn |
| 24900582 |
8 |
Anabaseine analogues as modulators of nicotinic acetylcholine receptor. |
Dart Neuroscience |
| 23116890 |
5 |
Synthesis and evaluation of 3-¹²³I-iodo-5-[2-(S)-3-pyrrolinylmethoxy]-pyridine (niodene) as a potential nicotinic ?4?2 receptor imaging agent. |
University of California - Irvine |
| 21962147 |
113 |
Structure-activity studies of diazabicyclo[3.3.0]octane-substituted pyrazines and pyridines as potent ?4?2 nicotinic acetylcholine receptor ligands. |
Abbott Laboratories |
| 20493692 |
7 |
In silico characterization of cytisinoids docked into an acetylcholine binding protein. |
Instituto De Investigaciones Biol£Gicas Clemente Estable |
| 16722635 |
27 |
New ligands with affinity for the alpha4beta2 subtype of nicotinic acetylcholine receptors. Synthesis, receptor binding, and 3D-QSAR modeling. |
Neurosearch |
| 16640326 |
104 |
Synthesis and pharmacological evaluation of novel 9- and 10-substituted cytisine derivatives. Nicotinic ligands of enhanced subtype selectivity. |
University of Illinois At Chicago |
| 16039849 |
84 |
Epibatidine analogues as selective ligands for the alpha(x)beta2-containing subtypes of nicotinic acetylcholine receptors. |
Columbia University College of Physicians and Surgeons |
| 16039854 |
31 |
3-(2-Aminoethyl)pyridine analogs as alpha4beta2 nicotinic cholinergic receptor ligands. |
Virginia Commonwealth University |
| 16078832 |
25 |
Ligand selectivity for the acetylcholine binding site of the rat alpha4beta2 and alpha3beta4 nicotinic subtypes investigated by molecular docking. |
Swiss Federal Institute of Technology Zurich |
| 15925512 |
23 |
6-(2-Phenylethyl)nicotine: a novel nicotinic cholinergic receptor ligand. |
Virginia Commonwealth University |
| 15482927 |
1 |
Nocathiacin I analogues: synthesis, in vitro and in vivo biological activity of novel semi-synthetic thiazolyl peptide antibiotics. |
The Bristol-Myers Squibb Pharmaceutical Research Institute |
| 15115389 |
23 |
5-substituted derivatives of 6-halogeno-3-((2-(S)-azetidinyl)methoxy)pyridine and 6-halogeno-3-((2-(S)-pyrrolidinyl)methoxy)pyridine with low picomolar affinity for alpha4beta2 nicotinic acetylcholine receptor and wide range of lipophilicity: potential probes for imaging with positron emission tomog |
National Institute On Drug Abuse |
| 12620069 |
42 |
Synthesis, nicotinic acetylcholine receptor binding affinities, and molecular modeling of constrained epibatidine analogues. |
Georgetown University Medical Center |
| 12747776 |
67 |
3D QSAR analyses-guided rational design of novel ligands for the (alpha4)2(beta2)3 nicotinic acetylcholine receptor. |
Institut F£R Pharmazeutische Chemie Der Philipps-Universit£T Marburg |
| 12190326 |
11 |
Conformationally constrained nicotines: polycyclic, bridged, and spiro-annulated analogues as novel ligands for the nicotinic acetylcholine receptor. |
Vienna University of Technology |
| 12086489 |
19 |
Synthesis and biological evaluation at nicotinic acetylcholine receptors of N-arylalkyl- and N-aryl-7-azabicyclo[2.2.1]heptanes. |
University of New Orleans |
| 11689081 |
86 |
Structure-affinity relationships of a unique nicotinic ligand: N(1)-dimethyl-N(4)-phenylpiperazinium iodide (DMPP). |
Universit£ |
| 10377228 |
31 |
Novel and potent 6-chloro-3-pyridinyl ligands for the alpha4beta2 neuronal nicotinic acetylcholine receptor. |
University of California |
| 29671588 |
35 |
Absolute Configuration and Pharmacology of the Poison Frog Alkaloid Phantasmidine. |
Indiana State University |
| 30252466 |
37 |
Single Amino Acid Substitution in ?-Conotoxin TxID Reveals a Specific ?3?4 Nicotinic Acetylcholine Receptor Antagonist. |
Hainan University |
| 29050783 |
40 |
Design and synthesis of a novel series of (1'S,2R,4'S)-3H-4'-azaspiro[benzo[4,5]imidazo[2,1-b]oxazole-2,2'-bicyclo[2.2.2]octanes] with high affinity for the ?7 neuronal nicotinic receptor. |
Bristol-Myers Squibb Pharmaceutical Research Institute |
| 29751234 |
94 |
Pyridinyl- and pyridazinyl-3,6-diazabicyclo[3.1.1]heptane-anilines: Novel selective ligands with subnanomolar affinity for ? |
Istituto Di Chimica Biomolecolare |
| 29384668 |
249 |
Dual Nicotinic Acetylcholine Receptor ?4?2 Antagonists/?7 Agonists: Synthesis, Docking Studies, and Pharmacological Evaluation of Tetrahydroisoquinolines and Tetrahydroisoquinolinium Salts. |
University of Copenhagen |
| 27810599 |
14 |
From pyrrolidinyl-benzodioxane to pyrrolidinyl-pyridodioxanes, or from unselective antagonism to selective partial agonism at?4?2 nicotinic acetylcholine receptor. |
Universit£ |
| 29178785 |
61 |
Highly Selective and Potent?4?2 nAChR Antagonist Inhibits Nicotine Self-Administration and Reinstatement in Rats. |
Torrey Pines Institute For Molecular Studies |
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