47 articles for thisTarget

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The following articles (labelled with PubMed ID or TBD) are for your review

PMID	Data	Article Title	Organization
25782055	9	Discovery of a Cyclic Boronic Acidß-Lactamase Inhibitor (RPX7009) with Utility vs Class A Serine Carbapenemases.	Rempex Pharmaceuticals
23719288	41	Discovery of novel series of 6-benzyl substituted 4-aminocarbonyl-1,4-diazepane-2,5-diones as human chymase inhibitors using structure-based drug design.	Asubio Pharma
23659209	30	Discovery of potent, selective chymase inhibitors via fragment linking strategies.	Boehringer Ingelheim Pharmaceuticals
16644215	52	Design and synthesis of selective keto-1,2,4-oxadiazole-based tryptase inhibitors.	Celera Genomics
19715320	87	Grassystatins A-C from marine cyanobacteria, potent cathepsin E inhibitors that reduce antigen presentation.	University Of Florida
18053726	364	Inhibitors of proteases and amide hydrolases that employ an alpha-ketoheterocycle as a key enabling functionality.	Johnson & Johnson Pharmaceutical Research & Development
18247547	6	Discovery of a potent, selective, and orally active proteasome inhibitor for the treatment of cancer.	Cephalon
11312928	62	Synthesis, structure-activity relationships, and pharmacokinetic profiles of nonpeptidic difluoromethylene ketones as novel inhibitors of human chymase.	Welfide
11312927	64	Synthesis, structure-activity relationships, and pharmacokinetic profiles of nonpeptidic alpha-keto heterocycles as novel inhibitors of human chymase.	Welfide
22192588	9	Structure-based library design and the discovery of a potent and selective mast cellß-tryptase inhibitor as an oral therapeutic agent.	Sanofi Pharmaceuticals
21733690	40	Benzimidazolone as potent chymase inhibitor: modulation of reactive metabolite formation in the hydrophobic (P1) region.	Boehringer Ingelheim Pharmaceuticals
20970895	4	2-Azetidinone--a new profile of various pharmacological activities.	Barkatullah University
19841155	29	MK-7009, a potent and selective inhibitor of hepatitis C virus NS3/4A protease.	Merck Research Laboratories
20102150	35	Discovery and clinical evaluation of 1-{N-[2-(amidinoaminooxy)ethyl]amino}carbonylmethyl-6-methyl-3-[2,2-difluoro-2-phenylethylamino]pyrazinone (RWJ-671818), a thrombin inhibitor with an oxyguanidine P1 motif.	Johnson & Johnson Pharmaceutical Research And Development
19908842	84	Identification and optimization of inhibitors of Trypanosomal cysteine proteases: cruzain, rhodesain, and TbCatB.	National Human Genome Research Institute
17434735	34	Development of 6-benzyl substituted 4-aminocarbonyl-1,4-diazepane-2,5-diones as orally active human chymase inhibitors.	Daiichi Asubio Pharma
17419055	30	Identification of 6-substituted 4-arylsulfonyl-1,4-diazepane-2,5-diones as a novel scaffold for human chymase inhibitors.	Daiichi Asubio Pharma
17361995	31	Discovery of potent, selective, orally active, nonpeptide inhibitors of human mast cell chymase.	Johnson & Johnson Pharmaceutical Research And Development
16725321	13	Novel, potent, selective, and orally bioavailable human betaII-tryptase inhibitors.	Celera Genomics
14592513	24	Structure-activity relationship of benzo[b]thiophene-2-sulfonamide derivatives as novel human chymase inhibitors.	Toa Eiyo
12467610	1	Identification of a stable chymase inhibitor using a pharmacophore-Based database search.	Toa Eiyo
11425540	6	Total synthesis of human chymase inhibitor methyllinderone and structure--activity relationships of its derivatives.	Shionogi
11425539	23	Inhibition of serine proteases: activity of 1,3-diazetidine-2,4-diones.	Shionogi
32150407	27	Discovery of Cyclic Boronic Acid QPX7728, an Ultrabroad-Spectrum Inhibitor of Serine and Metallo-?-lactamases.	Qpex Biopharma
11078188	20	1-Oxacephem-based human chymase inhibitors: discovery of stable inhibitors in human plasma.	Shionogi
11078187	36	Synthesis and structure-activity relationships of a new class of 1-oxacephem-based human chymase inhibitors.	Shionogi
10698435	150	Structure-activity relationship studies of chloromethyl ketone derivatives for selective human chymase inhibitors.	Kyoto Pharmaceutical University
10091694	90	Symmetrical anhydride-type serine protease inhibitors: structure-activity relationship studies of human chymase inhibitors.	Nippon Steel
31855419	63	Binding Loop Substitutions in the Cyclic Peptide SFTI-1 Generate Potent and Selective Chymase Inhibitors.	The University Of Queensland
9925737	57	N-[2,2-dimethyl-3-(N-(4-cyanobenzoyl)amino)nonanoyl]-L-phenylalanine ethyl ester as a stable ester-type inhibitor of chymotrypsin-like serine proteases: structural requirements for potent inhibition of alpha-chymotrypsin.	Nippon Steel
9871512	20	Peptidyl human heart chymase inhibitors. 2. Discovery of highly selective difluoromethylene ketone derivatives with Glu at P3 site.	Green Cross Research Laboratories
9871511	54	Peptidyl human heart chymase inhibitors. 1. Synthesis and inhibitory activity of difluoromethylene ketone derivatives bearing P' binding subsites.	Green Cross Research Laboratories
30366253	11	Naphthalene, a versatile platform in medicinal chemistry: Sky-high perspective.	Indian Institute Of Technology (Bhu)
9216834	153	Substituted 3-(phenylsulfonyl)-1-phenylimidazolidine-2,4-dione derivatives as novel nonpeptide inhibitors of human heart chymase.	Suntory
31413811	26	Iterative Optimization of the Cyclic Peptide SFTI-1 Yields Potent Inhibitors of Neutrophil Proteinase 3.	The University Of Queensland
21397370	2	SPF32629A and SPF32629B: enantioselective synthesis, determination of absolute configuration, cytotoxicity and antibacterial evaluation.	Gvk Biosciences
29191554	11	Structure-based design, synthesis, and binding mode analysis of novel and potent chymase inhibitors.	Asubio Pharma
30015488	44	Discovery, Synthesis, Pharmacological Profiling, and Biological Characterization of Brintonamides A-E, Novel Dual Protease and GPCR Modulators from a Marine Cyanobacterium.	University Of Florida
28045523	35	Design of Potent and Selective Cathepsin G Inhibitors Based on the Sunflower Trypsin Inhibitor-1 Scaffold.	The University Of Queensland
15449728	11	Design and synthesis of indole and tetrahydroisoquinoline hydantoin derivatives as human chymase inhibitors.	UniversitÉ
9468142	60	Design of potent selective zinc-mediated serine protease inhibitors.	Arris