BindingDB PrimarySearch

BDBM50157304 3',5-di-2-propenyl-1,1'-biphenyl-2,4'-diol::3',5-diallylbiphenyl-2,4'-diol::5,3''-Diallyl-biphenyl-2,4''-diol::5,3'-diallyl-biphenyl-2,4'-diol::CHEMBL16901::HONOKIOL::Honokiol, HO::cid_72303

SMILES: Oc1ccc(cc1CC=C)-c1cc(CC=C)ccc1O

InChI Key: InChIKey=FVYXIJYOAGAUQK-UHFFFAOYSA-N

Data: 5 KI 6 IC50 4 EC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 17 hits for monomerid = 50157304
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Cannabinoid receptor 2 (Homo sapiens (Human))	BDBM50157304 (3',5-di-2-propenyl-1,1'-biphenyl-2,4'-diol \| 3',5-...) Show SMILES Oc1ccc(cc1CC=C)-c1cc(CC=C)ccc1O Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	5.60	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ di Pisa Curated by ChEMBL					Assay Description Displacement of [3H]CP55940 from human CB2 receptor expressed in CHO cell membranes after 2 hrs				Eur J Med Chem 116: 252-266 (2016) Article DOI: 10.1016/j.ejmech.2016.03.072 BindingDB Entry DOI: 10.7270/Q2DJ5HHP
Universit£ di Pisa Curated by ChEMBL					More data for this Ligand-Target Pair
Cannabinoid receptor 1 (Homo sapiens (Human))	BDBM50157304 (3',5-di-2-propenyl-1,1'-biphenyl-2,4'-diol \| 3',5-...) Show SMILES Oc1ccc(cc1CC=C)-c1cc(CC=C)ccc1O Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	6.5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ di Pisa Curated by ChEMBL					Assay Description Displacement of [3H]CP55940 from human CB1 receptor expressed in CHO cell membranes after 2 hrs				Eur J Med Chem 116: 252-266 (2016) Article DOI: 10.1016/j.ejmech.2016.03.072 BindingDB Entry DOI: 10.7270/Q2DJ5HHP
Universit£ di Pisa Curated by ChEMBL					More data for this Ligand-Target Pair
Cannabinoid receptor 2 (Homo sapiens (Human))	BDBM50157304 (3',5-di-2-propenyl-1,1'-biphenyl-2,4'-diol \| 3',5-...) Show SMILES Oc1ccc(cc1CC=C)-c1cc(CC=C)ccc1O Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	1.76E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Bern					Assay Description Binding assay with hCB1 and hCB2 receptors.				Chem Biol 18: 1053-64 (2011) Article DOI: 10.1016/j.chembiol.2011.05.012 BindingDB Entry DOI: 10.7270/Q27W69PQ
University of Bern					More data for this Ligand-Target Pair
Cannabinoid receptor 2 (Homo sapiens (Human))	BDBM50157304 (3',5-di-2-propenyl-1,1'-biphenyl-2,4'-diol \| 3',5-...) Show SMILES Oc1ccc(cc1CC=C)-c1cc(CC=C)ccc1O Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	5.61E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Bonn Curated by ChEMBL					Assay Description Displacement of [3H]CP55,940 from recombinant human CB2 receptor expressed in CHO cells after 2 hrs by liquid scintillation counting				ACS Med Chem Lett 4: 41-5 (2013) Article DOI: 10.1021/ml300235q BindingDB Entry DOI: 10.7270/Q2SF2XHW
University of Bonn Curated by ChEMBL					More data for this Ligand-Target Pair
Cannabinoid receptor 1 (Homo sapiens (Human))	BDBM50157304 (3',5-di-2-propenyl-1,1'-biphenyl-2,4'-diol \| 3',5-...) Show SMILES Oc1ccc(cc1CC=C)-c1cc(CC=C)ccc1O Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	6.46E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Bonn Curated by ChEMBL					Assay Description Displacement of [3H]CP55,940 from recombinant human CB1 receptor expressed in CHO cells after 2 hrs by liquid scintillation counting				ACS Med Chem Lett 4: 41-5 (2013) Article DOI: 10.1021/ml300235q BindingDB Entry DOI: 10.7270/Q2SF2XHW
University of Bonn Curated by ChEMBL					More data for this Ligand-Target Pair
Platelet glycoprotein VI (Homo sapiens (Human))	BDBM50157304 (3',5-di-2-propenyl-1,1'-biphenyl-2,4'-diol \| 3',5-...) Show SMILES Oc1ccc(cc1CC=C)-c1cc(CC=C)ccc1O Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG PC cid PC sid UniChem Patents Similars		n/a	n/a	n/a	2.89E+5	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
TBA					More data for this Ligand-Target Pair
GABA-A receptor; GABA-A site (alpha1/beta2 interface) (Homo sapiens (Human))	BDBM50157304 (3',5-di-2-propenyl-1,1'-biphenyl-2,4'-diol \| 3',5-...) Show SMILES Oc1ccc(cc1CC=C)-c1cc(CC=C)ccc1O Show InChI	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	3.93E+4	n/a	n/a	n/a	n/a
University of Vienna Curated by ChEMBL					Assay Description Modulation of GABA Aalpha1beta2 receptor expressed in Xenopus laevis oocytes assessed as potentiation of GABA-induced chloride current at holding pot...				J Med Chem 54: 5349-61 (2011) Article DOI: 10.1021/jm200186n BindingDB Entry DOI: 10.7270/Q2QR4XGP
University of Vienna Curated by ChEMBL					More data for this Ligand-Target Pair
Cannabinoid receptor 1 (Homo sapiens (Human))	BDBM50157304 (3',5-di-2-propenyl-1,1'-biphenyl-2,4'-diol \| 3',5-...) Show SMILES Oc1ccc(cc1CC=C)-c1cc(CC=C)ccc1O Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a
University of Bonn Curated by ChEMBL					Assay Description Agonist activity at recombinant human CB1 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 5 mins ...				ACS Med Chem Lett 4: 41-5 (2013) Article DOI: 10.1021/ml300235q BindingDB Entry DOI: 10.7270/Q2SF2XHW
University of Bonn Curated by ChEMBL					More data for this Ligand-Target Pair
Neuraminidase (Influenza A virus)	BDBM50157304 (3',5-di-2-propenyl-1,1'-biphenyl-2,4'-diol \| 3',5-...) Show SMILES Oc1ccc(cc1CC=C)-c1cc(CC=C)ccc1O Show InChI	PDB MMDB B.MOAD GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	3.01E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Innsbruck Curated by ChEMBL					Assay Description Inhibition of Influenza A virus (A/Puerto Rico/8/1934(H1N1)) neuraminidase by chemiluminescence based assay				J Nat Prod 77: 563-70 (2014) Article DOI: 10.1021/np400817j BindingDB Entry DOI: 10.7270/Q23J3GZJ
University of Innsbruck Curated by ChEMBL					More data for this Ligand-Target Pair
Neuraminidase (Influenza A virus)	BDBM50157304 (3',5-di-2-propenyl-1,1'-biphenyl-2,4'-diol \| 3',5-...) Show SMILES Oc1ccc(cc1CC=C)-c1cc(CC=C)ccc1O Show InChI	PDB MMDB B.MOAD GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.39E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Innsbruck Curated by ChEMBL					Assay Description Inhibition of oseltamivir-resistant Influenza A virus H1N1 B/55/08 neuraminidase by chemiluminescence based assay				J Nat Prod 77: 563-70 (2014) Article DOI: 10.1021/np400817j BindingDB Entry DOI: 10.7270/Q23J3GZJ
University of Innsbruck Curated by ChEMBL					More data for this Ligand-Target Pair
Platelet glycoprotein VI (Homo sapiens (Human))	BDBM50157304 (3',5-di-2-propenyl-1,1'-biphenyl-2,4'-diol \| 3',5-...) Show SMILES Oc1ccc(cc1CC=C)-c1cc(CC=C)ccc1O Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG PC cid PC sid UniChem Patents Similars		n/a	n/a	n/a	2.89E+5	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
TBA					More data for this Ligand-Target Pair
Arachidonate 5-lipoxygenase (Homo sapiens (Human))	BDBM50157304 (3',5-di-2-propenyl-1,1'-biphenyl-2,4'-diol \| 3',5-...) Show SMILES Oc1ccc(cc1CC=C)-c1cc(CC=C)ccc1O Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	4.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
Karl-Franzens-Universit£t Graz Curated by ChEMBL					Assay Description Inhibition of 5LOX-mediated LTB4 formation in stimulated human polymorphonuclear leukocytes				Bioorg Med Chem 17: 4459-65 (2009) Article DOI: 10.1016/j.bmc.2009.05.018 BindingDB Entry DOI: 10.7270/Q2SX6D9B
Karl-Franzens-Universit£t Graz Curated by ChEMBL					More data for this Ligand-Target Pair
Prostaglandin G/H synthase (Cyclooxygenase-2) (Ovis aries (Sheep))	BDBM50157304 (3',5-di-2-propenyl-1,1'-biphenyl-2,4'-diol \| 3',5-...) Show SMILES Oc1ccc(cc1CC=C)-c1cc(CC=C)ccc1O Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	2.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
Karl-Franzens-Universit£t Graz Curated by ChEMBL					Assay Description Inhibition of COX2 in sheep placental vesicle by enzyme immunoassay				Bioorg Med Chem 17: 4459-65 (2009) Article DOI: 10.1016/j.bmc.2009.05.018 BindingDB Entry DOI: 10.7270/Q2SX6D9B
Karl-Franzens-Universit£t Graz Curated by ChEMBL					More data for this Ligand-Target Pair
Prostaglandin G/H synthase (cyclooxygenase) (Ovis aries (Sheep))	BDBM50157304 (3',5-di-2-propenyl-1,1'-biphenyl-2,4'-diol \| 3',5-...) Show SMILES Oc1ccc(cc1CC=C)-c1cc(CC=C)ccc1O Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.80E+3	n/a	n/a	n/a	n/a	n/a	n/a
Karl-Franzens-Universit£t Graz Curated by ChEMBL					Assay Description Inhibition of COX1 in ram seminal vesicle by enzyme immunoassay				Bioorg Med Chem 17: 4459-65 (2009) Article DOI: 10.1016/j.bmc.2009.05.018 BindingDB Entry DOI: 10.7270/Q2SX6D9B
Karl-Franzens-Universit£t Graz Curated by ChEMBL					More data for this Ligand-Target Pair
GABA-A receptor; alpha-1/beta-2/gamma-2 (Homo sapiens (Human))	BDBM50157304 (3',5-di-2-propenyl-1,1'-biphenyl-2,4'-diol \| 3',5-...) Show SMILES Oc1ccc(cc1CC=C)-c1cc(CC=C)ccc1O Show InChI	PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	n/a	n/a	7.62E+4	n/a	n/a	n/a	n/a
University of Graz Curated by ChEMBL					Assay Description Partial agonist activity at GABAAalpha1beta2gamma2s receptor (unknown origin) expressed in Xenopus laevis oocytes assessed as induction of chloride c...				Bioorg Med Chem 23: 6757-62 (2015) BindingDB Entry DOI: 10.7270/Q2WQ05KM
University of Graz Curated by ChEMBL					More data for this Ligand-Target Pair
TPA: Essential protein of the mitochondrial intermembrane space (Saccharomyces cerevisiae S288c)	BDBM50157304 (3',5-di-2-propenyl-1,1'-biphenyl-2,4'-diol \| 3',5-...) Show SMILES Oc1ccc(cc1CC=C)-c1cc(CC=C)ccc1O Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG PC cid PC sid UniChem Patents Similars	PCBioAssay	n/a	n/a	4.88E+4	n/a	n/a	n/a	n/a	n/a	n/a
Burnham Center for Chemical Genomics Curated by PubChem BioAssay					Assay Description Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford-Burnham Medical Research Institute(SBMRI, San Diego, CA...				PubChem Bioassay (2010) BindingDB Entry DOI: 10.7270/Q2F18X6W
					More data for this Ligand-Target Pair
Retinoic acid receptor RXR-alpha (Homo sapiens (Human))	BDBM50157304 (3',5-di-2-propenyl-1,1'-biphenyl-2,4'-diol \| 3',5-...) Show SMILES Oc1ccc(cc1CC=C)-c1cc(CC=C)ccc1O Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	1.18E+4	n/a	n/a	n/a	n/a
Aichi Gakuin University Curated by ChEMBL					Assay Description Agonist activity at RXRalpha in HEK293 cells assessed as transcriptional activation after 48 hrs by luciferase reporter gene assay				J Nat Prod 73: 1332-6 (2010) Article DOI: 10.1021/np100120c BindingDB Entry DOI: 10.7270/Q2VT1S9K
Aichi Gakuin University Curated by ChEMBL					More data for this Ligand-Target Pair