BDBM50185433 CHEMBL3824068
SMILES: CN1CCN(CC1)c1ccc(cc1)-n1cc(cn1)-c1ccncc1OCC1CCNCC1
InChI Key: InChIKey=BLFBSGVUERKSST-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
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Maternal embryonic leucine zipper kinase (Homo sapiens (Human)) | BDBM50185433 (CHEMBL3824068) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars | PDB PubMed | n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for Biomedical Research Curated by ChEMBL | Assay Description Inhibition of MELK catalytic domain (unknown origin) preincubated for 20 mins followed by addition of KinEASE STK S1 peptide as substrate in presence... | J Med Chem 59: 4711-23 (2016) BindingDB Entry DOI: 10.7270/Q2MK6FTG | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Receptor-type tyrosine-protein kinase FLT3 (Homo sapiens (Human)) | BDBM50185433 (CHEMBL3824068) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars | PubMed | n/a | n/a | 180 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for Biomedical Research Curated by ChEMBL | Assay Description Inhibition of partial-length human FLT3 ITD mutant expressed in bacterial expression system by KINOMEscan assay | J Med Chem 59: 4711-23 (2016) BindingDB Entry DOI: 10.7270/Q2MK6FTG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serine/threonine-protein kinase haspin (Homo sapiens (Human)) | BDBM50185433 (CHEMBL3824068) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars | PubMed | n/a | n/a | 190 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for Biomedical Research Curated by ChEMBL | Assay Description Inhibition of partial-length human wild type HASPIN expressed in mammalian expression system by KINOMEscan assay | J Med Chem 59: 4711-23 (2016) BindingDB Entry DOI: 10.7270/Q2MK6FTG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Maternal embryonic leucine zipper kinase (Homo sapiens (Human)) | BDBM50185433 (CHEMBL3824068) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars | PDB PubMed | n/a | n/a | 140 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for Biomedical Research Curated by ChEMBL | Assay Description Inhibition of MELK catalytic domain (unknown origin) preincubated for 20 mins followed by addition of KinEASE STK S1 peptide as substrate in presence... | J Med Chem 59: 4711-23 (2016) BindingDB Entry DOI: 10.7270/Q2MK6FTG | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Platelet-derived growth factor receptor alpha (Homo sapiens (Human)) | BDBM50185433 (CHEMBL3824068) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars | PubMed | n/a | n/a | 420 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for Biomedical Research Curated by ChEMBL | Assay Description Inhibition of partial-length human wild type PDGFR-alpha expressed in mammalian expression system by KINOMEscan assay | J Med Chem 59: 4711-23 (2016) BindingDB Entry DOI: 10.7270/Q2MK6FTG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Maternal embryonic leucine zipper kinase (Homo sapiens (Human)) | BDBM50185433 (CHEMBL3824068) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars | PDB PubMed | n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for Biomedical Research Curated by ChEMBL | Assay Description Binding affinity to MELK (unknown origin) expressed in Escherichia coli by SPR analysis | J Med Chem 59: 4711-23 (2016) BindingDB Entry DOI: 10.7270/Q2MK6FTG | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Maternal embryonic leucine zipper kinase (Homo sapiens (Human)) | BDBM50185433 (CHEMBL3824068) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars | PDB PubMed | n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for Biomedical Research Curated by ChEMBL | Assay Description Inhibition of full-length MELK (unknown origin) preincubated for 20 mins followed by addition of KinEASE STK S1 peptide as substrate in presence of 2... | J Med Chem 59: 4711-23 (2016) BindingDB Entry DOI: 10.7270/Q2MK6FTG | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Mast/stem cell growth factor receptor Kit (Homo sapiens (Human)) | BDBM50185433 (CHEMBL3824068) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars | PubMed | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for Biomedical Research Curated by ChEMBL | Assay Description Inhibition of partial-length human KIT A829P mutant expressed in mammalian expression system by KINOMEscan assay | J Med Chem 59: 4711-23 (2016) BindingDB Entry DOI: 10.7270/Q2MK6FTG | |||||||||||
More data for this Ligand-Target Pair |