BDBM50194655 (2R)-N-(1-cyclopentyl-4-piperidinylmethyl)-1-((2S,4R)-4-hydroxy-1-[3,3,3-tris(4-fluorophenyl)-propanoyl]pyrrolidine-2-yl)carbonylpyrrolidine-2-carboxamide::CHEMBL212645

SMILES: O[C@@H]1C[C@H](N(C1)C(=O)CC(c1ccc(F)cc1)(c1ccc(F)cc1)c1ccc(F)cc1)C(=O)N1CCC[C@@H]1C(=O)NCC1CCN(CC1)C1CCCC1

InChI Key: InChIKey=SSQJHXZOEJZLAK-IZNNDHRXSA-N

Data: 5 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50194655   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Muscarinic acetylcholine receptor M3 (Homo sapiens (Human))	BDBM50194655 ((2R)-N-(1-cyclopentyl-4-piperidinylmethyl)-1-((2S,...) Show SMILES O[C@@H]1C[C@H](N(C1)C(=O)CC(c1ccc(F)cc1)(c1ccc(F)cc1)c1ccc(F)cc1)C(=O)N1CCC[C@@H]1C(=O)NCC1CCN(CC1)C1CCCC1 Show InChI InChI=1S/C42H49F3N4O4/c43-32-13-7-29(8-14-32)42(30-9-15-33(44)16-10-30,31-11-17-34(45)18-12-31)25-39(51)49-27-36(50)24-38(49)41(53)48-21-3-6-37(48)40(52)46-26-28-19-22-47(23-20-28)35-4-1-2-5-35/h7-18,28,35-38,50H,1-6,19-27H2,(H,46,52)/t36-,37-,38+/m1/s1	Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	0.510	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Tsukuba Research Institute Curated by ChEMBL					Assay Description Inhibition of [3H]NMS binding to human cloned M3 receptor expressed in CHO cells				J Med Chem 49: 5653-63 (2006) Article DOI: 10.1021/jm051205r BindingDB Entry DOI: 10.7270/Q2F76C6K
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M4 (Homo sapiens (Human))	BDBM50194655 ((2R)-N-(1-cyclopentyl-4-piperidinylmethyl)-1-((2S,...) Show SMILES O[C@@H]1C[C@H](N(C1)C(=O)CC(c1ccc(F)cc1)(c1ccc(F)cc1)c1ccc(F)cc1)C(=O)N1CCC[C@@H]1C(=O)NCC1CCN(CC1)C1CCCC1 Show InChI InChI=1S/C42H49F3N4O4/c43-32-13-7-29(8-14-32)42(30-9-15-33(44)16-10-30,31-11-17-34(45)18-12-31)25-39(51)49-27-36(50)24-38(49)41(53)48-21-3-6-37(48)40(52)46-26-28-19-22-47(23-20-28)35-4-1-2-5-35/h7-18,28,35-38,50H,1-6,19-27H2,(H,46,52)/t36-,37-,38+/m1/s1	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	48	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Tsukuba Research Institute Curated by ChEMBL					Assay Description Inhibition of [3H]NMS binding to human cloned M4 receptor expressed in CHO cells				J Med Chem 49: 5653-63 (2006) Article DOI: 10.1021/jm051205r BindingDB Entry DOI: 10.7270/Q2F76C6K
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M2 (Homo sapiens (Human))	BDBM50194655 ((2R)-N-(1-cyclopentyl-4-piperidinylmethyl)-1-((2S,...) Show SMILES O[C@@H]1C[C@H](N(C1)C(=O)CC(c1ccc(F)cc1)(c1ccc(F)cc1)c1ccc(F)cc1)C(=O)N1CCC[C@@H]1C(=O)NCC1CCN(CC1)C1CCCC1 Show InChI InChI=1S/C42H49F3N4O4/c43-32-13-7-29(8-14-32)42(30-9-15-33(44)16-10-30,31-11-17-34(45)18-12-31)25-39(51)49-27-36(50)24-38(49)41(53)48-21-3-6-37(48)40(52)46-26-28-19-22-47(23-20-28)35-4-1-2-5-35/h7-18,28,35-38,50H,1-6,19-27H2,(H,46,52)/t36-,37-,38+/m1/s1	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	110	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Tsukuba Research Institute Curated by ChEMBL					Assay Description Inhibition of [3H]NMS binding to human cloned M2 receptor expressed in CHO cells				J Med Chem 49: 5653-63 (2006) Article DOI: 10.1021/jm051205r BindingDB Entry DOI: 10.7270/Q2F76C6K
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1 (Homo sapiens (Human))	BDBM50194655 ((2R)-N-(1-cyclopentyl-4-piperidinylmethyl)-1-((2S,...) Show SMILES O[C@@H]1C[C@H](N(C1)C(=O)CC(c1ccc(F)cc1)(c1ccc(F)cc1)c1ccc(F)cc1)C(=O)N1CCC[C@@H]1C(=O)NCC1CCN(CC1)C1CCCC1 Show InChI InChI=1S/C42H49F3N4O4/c43-32-13-7-29(8-14-32)42(30-9-15-33(44)16-10-30,31-11-17-34(45)18-12-31)25-39(51)49-27-36(50)24-38(49)41(53)48-21-3-6-37(48)40(52)46-26-28-19-22-47(23-20-28)35-4-1-2-5-35/h7-18,28,35-38,50H,1-6,19-27H2,(H,46,52)/t36-,37-,38+/m1/s1	UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	210	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Tsukuba Research Institute Curated by ChEMBL					Assay Description Inhibition of [3H]NMS binding to human cloned M1 receptor expressed in CHO cells				J Med Chem 49: 5653-63 (2006) Article DOI: 10.1021/jm051205r BindingDB Entry DOI: 10.7270/Q2F76C6K
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M5 (Homo sapiens (Human))	BDBM50194655 ((2R)-N-(1-cyclopentyl-4-piperidinylmethyl)-1-((2S,...) Show SMILES O[C@@H]1C[C@H](N(C1)C(=O)CC(c1ccc(F)cc1)(c1ccc(F)cc1)c1ccc(F)cc1)C(=O)N1CCC[C@@H]1C(=O)NCC1CCN(CC1)C1CCCC1 Show InChI InChI=1S/C42H49F3N4O4/c43-32-13-7-29(8-14-32)42(30-9-15-33(44)16-10-30,31-11-17-34(45)18-12-31)25-39(51)49-27-36(50)24-38(49)41(53)48-21-3-6-37(48)40(52)46-26-28-19-22-47(23-20-28)35-4-1-2-5-35/h7-18,28,35-38,50H,1-6,19-27H2,(H,46,52)/t36-,37-,38+/m1/s1	Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	3.20E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Tsukuba Research Institute Curated by ChEMBL					Assay Description Inhibition of [3H]NMS binding to human cloned M5 receptor expressed in CHO cells				J Med Chem 49: 5653-63 (2006) Article DOI: 10.1021/jm051205r BindingDB Entry DOI: 10.7270/Q2F76C6K
					More data for this Ligand-Target Pair