null
SMILES: COc1cc2CCN([C@@H](c3ccccc3)c2cc1OC)C(=O)N1CCc2cc(OC)c(OC)cc2[C@@H]1c1ccccc1
InChI Key: InChIKey=WEFAJZMOKCWZDL-HEVIKAOCSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Transient receptor potential cation channel subfamily V member 4 (Rattus norvegicus) | BDBM50535865 (CHEMBL4543647) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 8.26E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
National Research Council Curated by ChEMBL | Assay Description Antagonist activity at recombinant rat TRPV4 expressed in HEK293 cells assessed as inhibition of 4alphaPDD-induced intracellular calcium accumulation... | J Med Chem 59: 5661-83 (2016) Article DOI: 10.1021/acs.jmedchem.5b01448 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Transient receptor potential cation channel subfamily M member 8 (Rattus norvegicus (Rat)) | BDBM50535865 (CHEMBL4543647) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 500 | n/a | n/a | n/a | n/a | n/a | n/a |
National Research Council Curated by ChEMBL | Assay Description Antagonist activity at recombinant rat TRPM8 expressed in HEK293 cells assessed as inhibition of icilin-induced intracellular calcium accumulation pr... | J Med Chem 59: 5661-83 (2016) Article DOI: 10.1021/acs.jmedchem.5b01448 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Transient receptor potential cation channel subfamily V member 1 (Homo sapiens (Human)) | BDBM50535865 (CHEMBL4543647) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 5.30E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
National Research Council Curated by ChEMBL | Assay Description Antagonist activity at recombinant human TRPV1 expressed in HEK293 cells assessed as inhibition of capsaicin-induced intracellular calcium accumulati... | J Med Chem 59: 5661-83 (2016) Article DOI: 10.1021/acs.jmedchem.5b01448 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Transient receptor potential cation channel subfamily V member 2 (Rattus norvegicus) | BDBM50535865 (CHEMBL4543647) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 5.19E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
National Research Council Curated by ChEMBL | Assay Description Antagonist activity at recombinant rat TRPV2 expressed in HEK293 cells assessed as inhibition of LPC-induced intracellular calcium accumulation prein... | J Med Chem 59: 5661-83 (2016) Article DOI: 10.1021/acs.jmedchem.5b01448 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Transient receptor potential cation channel subfamily A member 1 (Rattus norvegicus) | BDBM50535865 (CHEMBL4543647) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
National Research Council Curated by ChEMBL | Assay Description Antagonist activity at recombinant rat TRPA1 expressed in HEK293 cells assessed as inhibition of AITC-induced intracellular calcium accumulation prei... | J Med Chem 59: 5661-83 (2016) Article DOI: 10.1021/acs.jmedchem.5b01448 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Heat sensitive channel TRPV3 (Rattus norvegicus) | BDBM50535865 (CHEMBL4543647) | PDB UniProtKB/TrEMBL GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
National Research Council Curated by ChEMBL | Assay Description Antagonist activity at recombinant rat TRPV3 expressed in HEK293 cells assessed as inhibition of thymol-induced intracellular calcium accumulation pr... | J Med Chem 59: 5661-83 (2016) Article DOI: 10.1021/acs.jmedchem.5b01448 | |||||||||||
More data for this Ligand-Target Pair |