Found 87 hits with Last Name = 'carreño' and Initial = 'c' Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Lysine--tRNA ligase
(Homo sapiens (Human)) | BDBM50390557
(CHEMBL2069346)Show SMILES FC(F)(F)c1ccnc(Nc2cccc(n2)-c2cccc(c2)N2CCNCC2)c1 Show InChI InChI=1S/C21H20F3N5/c22-21(23,24)16-7-8-26-20(14-16)28-19-6-2-5-18(27-19)15-3-1-4-17(13-15)29-11-9-25-10-12-29/h1-8,13-14,25H,9-12H2,(H,26,27,28) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
MMDB
PC cid
PC sid
PDB
UniChem
Similars
| Article
PubMed
| n/a | n/a | 0.600 | n/a | n/a | n/a | n/a | n/a | n/a |
Rhône-Poulenc Rorer
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant full-length Syk using poly-GT as substrate after 40 mins by radioactive filtration assay |
Bioorg Med Chem Lett 22: 5419-23 (2012)
Article DOI: 10.1016/j.bmcl.2012.07.045
BindingDB Entry DOI: 10.7270/Q2416Z4V |
More data for this
Ligand-Target Pair | |
Lysine--tRNA ligase
(Homo sapiens (Human)) | BDBM50390556
(CHEMBL2069345)Show SMILES FC(F)(F)c1ccnc(Nc2cccc(n2)-c2ccnc(c2)N2CCNCC2)c1 Show InChI InChI=1S/C20H19F3N6/c21-20(22,23)15-5-7-25-18(13-15)28-17-3-1-2-16(27-17)14-4-6-26-19(12-14)29-10-8-24-9-11-29/h1-7,12-13,24H,8-11H2,(H,25,27,28) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.80 | n/a | n/a | n/a | n/a | n/a | n/a |
Rhône-Poulenc Rorer
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant full-length Syk using poly-GT as substrate after 40 mins by radioactive filtration assay |
Bioorg Med Chem Lett 22: 5419-23 (2012)
Article DOI: 10.1016/j.bmcl.2012.07.045
BindingDB Entry DOI: 10.7270/Q2416Z4V |
More data for this
Ligand-Target Pair | |
Lysine--tRNA ligase
(Homo sapiens (Human)) | BDBM50390560
(CHEMBL2069349)Show InChI InChI=1S/C18H20N8/c19-14-10-15(24-16(11-14)25-17-12-21-3-4-22-17)13-1-2-23-18(9-13)26-7-5-20-6-8-26/h1-4,9-12,20H,5-8H2,(H3,19,22,24,25) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
Rhône-Poulenc Rorer
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant full-length Syk using poly-GT as substrate after 40 mins by radioactive filtration assay |
Bioorg Med Chem Lett 22: 5419-23 (2012)
Article DOI: 10.1016/j.bmcl.2012.07.045
BindingDB Entry DOI: 10.7270/Q2416Z4V |
More data for this
Ligand-Target Pair | |
Lysine--tRNA ligase
(Homo sapiens (Human)) | BDBM50390563
(CHEMBL2069352)Show SMILES O=C(Nc1cc(Nc2cnccn2)nc(c1)-c1ccnc(c1)N1CCNCC1)C1CCNCC1 Show InChI InChI=1S/C24H29N9O/c34-24(17-1-4-25-5-2-17)30-19-14-20(31-21(15-19)32-22-16-27-7-8-28-22)18-3-6-29-23(13-18)33-11-9-26-10-12-33/h3,6-8,13-17,25-26H,1-2,4-5,9-12H2,(H2,28,30,31,32,34) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
Rhône-Poulenc Rorer
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant full-length Syk using poly-GT as substrate after 40 mins by radioactive filtration assay |
Bioorg Med Chem Lett 22: 5419-23 (2012)
Article DOI: 10.1016/j.bmcl.2012.07.045
BindingDB Entry DOI: 10.7270/Q2416Z4V |
More data for this
Ligand-Target Pair | |
Lysine--tRNA ligase
(Homo sapiens (Human)) | BDBM50390561
(CHEMBL2069350)Show InChI InChI=1S/C19H22N8/c1-20-15-11-16(25-17(12-15)26-18-13-22-4-5-23-18)14-2-3-24-19(10-14)27-8-6-21-7-9-27/h2-5,10-13,21H,6-9H2,1H3,(H2,20,23,25,26) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
Rhône-Poulenc Rorer
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant full-length Syk using poly-GT as substrate after 40 mins by radioactive filtration assay |
Bioorg Med Chem Lett 22: 5419-23 (2012)
Article DOI: 10.1016/j.bmcl.2012.07.045
BindingDB Entry DOI: 10.7270/Q2416Z4V |
More data for this
Ligand-Target Pair | |
Lysine--tRNA ligase
(Homo sapiens (Human)) | BDBM50390568
(CHEMBL2069358)Show SMILES O=C(Cc1cccnc1)Nc1cc(Nc2cnccn2)nc(c1)-c1ccnc(c1)N1CCNCC1 Show InChI InChI=1S/C25H25N9O/c35-25(12-18-2-1-4-27-16-18)31-20-14-21(32-22(15-20)33-23-17-28-6-7-29-23)19-3-5-30-24(13-19)34-10-8-26-9-11-34/h1-7,13-17,26H,8-12H2,(H2,29,31,32,33,35) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
Rhône-Poulenc Rorer
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant full-length Syk using poly-GT as substrate after 40 mins by radioactive filtration assay |
Bioorg Med Chem Lett 22: 5419-23 (2012)
Article DOI: 10.1016/j.bmcl.2012.07.045
BindingDB Entry DOI: 10.7270/Q2416Z4V |
More data for this
Ligand-Target Pair | |
Lysine--tRNA ligase
(Homo sapiens (Human)) | BDBM50390564
(CHEMBL2069353)Show SMILES CC(=O)N1CCC(CC1)C(=O)Nc1cc(Nc2cnccn2)nc(c1)-c1ccnc(c1)N1CCNCC1 Show InChI InChI=1S/C26H31N9O2/c1-18(36)34-10-3-19(4-11-34)26(37)31-21-15-22(32-23(16-21)33-24-17-28-6-7-29-24)20-2-5-30-25(14-20)35-12-8-27-9-13-35/h2,5-7,14-17,19,27H,3-4,8-13H2,1H3,(H2,29,31,32,33,37) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
Rhône-Poulenc Rorer
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant full-length Syk using poly-GT as substrate after 40 mins by radioactive filtration assay |
Bioorg Med Chem Lett 22: 5419-23 (2012)
Article DOI: 10.1016/j.bmcl.2012.07.045
BindingDB Entry DOI: 10.7270/Q2416Z4V |
More data for this
Ligand-Target Pair | |
Lysine--tRNA ligase
(Homo sapiens (Human)) | BDBM50390566
(CHEMBL2069355)Show SMILES O=C(Nc1cc(Nc2cnccn2)nc(c1)-c1ccnc(c1)N1CCNCC1)c1cccnc1 Show InChI InChI=1S/C24H23N9O/c34-24(18-2-1-4-26-15-18)30-19-13-20(31-21(14-19)32-22-16-27-6-7-28-22)17-3-5-29-23(12-17)33-10-8-25-9-11-33/h1-7,12-16,25H,8-11H2,(H2,28,30,31,32,34) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 6 | n/a | n/a | n/a | n/a | n/a | n/a |
Rhône-Poulenc Rorer
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant full-length Syk using poly-GT as substrate after 40 mins by radioactive filtration assay |
Bioorg Med Chem Lett 22: 5419-23 (2012)
Article DOI: 10.1016/j.bmcl.2012.07.045
BindingDB Entry DOI: 10.7270/Q2416Z4V |
More data for this
Ligand-Target Pair | |
Lysine--tRNA ligase
(Homo sapiens (Human)) | BDBM50390567
(CHEMBL2069357)Show SMILES Cc1cc(C(=O)Nc2cc(Nc3cnccn3)nc(c2)-c2ccnc(c2)N2CCNCC2)n(C)n1 Show InChI InChI=1S/C24H26N10O/c1-16-11-20(33(2)32-16)24(35)29-18-13-19(30-21(14-18)31-22-15-26-5-6-27-22)17-3-4-28-23(12-17)34-9-7-25-8-10-34/h3-6,11-15,25H,7-10H2,1-2H3,(H2,27,29,30,31,35) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 7 | n/a | n/a | n/a | n/a | n/a | n/a |
Rhône-Poulenc Rorer
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant full-length Syk using poly-GT as substrate after 40 mins by radioactive filtration assay |
Bioorg Med Chem Lett 22: 5419-23 (2012)
Article DOI: 10.1016/j.bmcl.2012.07.045
BindingDB Entry DOI: 10.7270/Q2416Z4V |
More data for this
Ligand-Target Pair | |
Lysine--tRNA ligase
(Homo sapiens (Human)) | BDBM50390562
(CHEMBL2069351)Show SMILES Oc1ccc(CNc2cc(Nc3cnccn3)nc(c2)-c2ccnc(c2)N2CCNCC2)cc1 Show InChI InChI=1S/C25H26N8O/c34-21-3-1-18(2-4-21)16-30-20-14-22(31-23(15-20)32-24-17-27-7-8-28-24)19-5-6-29-25(13-19)33-11-9-26-10-12-33/h1-8,13-15,17,26,34H,9-12,16H2,(H2,28,30,31,32) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 8 | n/a | n/a | n/a | n/a | n/a | n/a |
Rhône-Poulenc Rorer
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant full-length Syk using poly-GT as substrate after 40 mins by radioactive filtration assay |
Bioorg Med Chem Lett 22: 5419-23 (2012)
Article DOI: 10.1016/j.bmcl.2012.07.045
BindingDB Entry DOI: 10.7270/Q2416Z4V |
More data for this
Ligand-Target Pair | |
Lysine--tRNA ligase
(Homo sapiens (Human)) | BDBM50390569
(CHEMBL2069359)Show SMILES OC(=O)c1ccc(cc1)C(=O)Nc1cc(Nc2cnccn2)nc(c1)-c1ccnc(c1)N1CCNCC1 Show InChI InChI=1S/C26H24N8O3/c35-25(17-1-3-18(4-2-17)26(36)37)31-20-14-21(32-22(15-20)33-23-16-28-7-8-29-23)19-5-6-30-24(13-19)34-11-9-27-10-12-34/h1-8,13-16,27H,9-12H2,(H,36,37)(H2,29,31,32,33,35) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 8 | n/a | n/a | n/a | n/a | n/a | n/a |
Rhône-Poulenc Rorer
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant full-length Syk using poly-GT as substrate after 40 mins by radioactive filtration assay |
Bioorg Med Chem Lett 22: 5419-23 (2012)
Article DOI: 10.1016/j.bmcl.2012.07.045
BindingDB Entry DOI: 10.7270/Q2416Z4V |
More data for this
Ligand-Target Pair | |
Lysine--tRNA ligase
(Homo sapiens (Human)) | BDBM50390573
(CHEMBL2069356)Show SMILES O=C(Nc1cc(Nc2cnccn2)nc(c1)-c1ccnc(c1)N1CCNCC1)c1cncnc1 Show InChI InChI=1S/C23H22N10O/c34-23(17-12-26-15-27-13-17)30-18-10-19(31-20(11-18)32-21-14-25-3-4-28-21)16-1-2-29-22(9-16)33-7-5-24-6-8-33/h1-4,9-15,24H,5-8H2,(H2,28,30,31,32,34) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 9 | n/a | n/a | n/a | n/a | n/a | n/a |
Rhône-Poulenc Rorer
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant full-length Syk using poly-GT as substrate after 40 mins by radioactive filtration assay |
Bioorg Med Chem Lett 22: 5419-23 (2012)
Article DOI: 10.1016/j.bmcl.2012.07.045
BindingDB Entry DOI: 10.7270/Q2416Z4V |
More data for this
Ligand-Target Pair | |
Lysine--tRNA ligase
(Homo sapiens (Human)) | BDBM50390571
(CHEMBL2069360)Show SMILES OC(=O)c1ccc(cn1)C(=O)Nc1cc(Nc2cnccn2)nc(c1)-c1ccnc(c1)N1CCNCC1 Show InChI InChI=1S/C25H23N9O3/c35-24(17-1-2-19(25(36)37)30-14-17)31-18-12-20(32-21(13-18)33-22-15-27-5-6-28-22)16-3-4-29-23(11-16)34-9-7-26-8-10-34/h1-6,11-15,26H,7-10H2,(H,36,37)(H2,28,31,32,33,35) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
Rhône-Poulenc Rorer
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant full-length Syk using poly-GT as substrate after 40 mins by radioactive filtration assay |
Bioorg Med Chem Lett 22: 5419-23 (2012)
Article DOI: 10.1016/j.bmcl.2012.07.045
BindingDB Entry DOI: 10.7270/Q2416Z4V |
More data for this
Ligand-Target Pair | |
Lysine--tRNA ligase
(Homo sapiens (Human)) | BDBM50390552
(CHEMBL2069341)Show InChI InChI=1S/C20H22N6/c1-15-5-7-22-19(13-15)25-18-4-2-3-17(24-18)16-6-8-23-20(14-16)26-11-9-21-10-12-26/h2-8,13-14,21H,9-12H2,1H3,(H,22,24,25) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 14 | n/a | n/a | n/a | n/a | n/a | n/a |
Rhône-Poulenc Rorer
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant full-length Syk using poly-GT as substrate after 40 mins by radioactive filtration assay |
Bioorg Med Chem Lett 22: 5419-23 (2012)
Article DOI: 10.1016/j.bmcl.2012.07.045
BindingDB Entry DOI: 10.7270/Q2416Z4V |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase receptor TYRO3
(Homo sapiens (Human)) | BDBM50380802
(CHEMBL2018145)Show SMILES Cn1cc(cn1)-c1cccc(c1)-c1cnc(N)c(n1)C(=O)N[C@H]1C2CC3CC1C[C@](O)(C3)C2 |r,wU:29.33,wD:22.24,TLB:30:29:22:26.24.25,21:22:28:26.25.31,THB:24:23:28:26.25.31,24:25:22.23.32:28,31:25:22:32.29.28,31:29:22:26.24.25,(-9.26,-3.44,;-7.71,-3.48,;-6.77,-2.25,;-5.32,-2.76,;-5.35,-4.3,;-6.83,-4.74,;-4.05,-1.88,;-4.02,-.34,;-2.69,.41,;-1.36,-.37,;-1.38,-1.92,;-2.73,-2.67,;-.06,-2.7,;-.08,-4.25,;1.24,-5.03,;2.59,-4.28,;3.91,-5.06,;2.6,-2.73,;1.28,-1.95,;3.94,-1.97,;5.27,-2.76,;3.95,-.43,;5.28,.33,;6.78,.72,;8.18,.13,;9.22,1.39,;7.81,1.07,;6.5,1.58,;6.51,3.07,;7.87,3.52,;7.92,5.06,;9.26,2.92,;6.81,2.3,)| Show InChI InChI=1S/C25H28N6O2/c1-31-13-19(11-28-31)15-3-2-4-16(7-15)20-12-27-23(26)22(29-20)24(32)30-21-17-5-14-6-18(21)10-25(33,8-14)9-17/h2-4,7,11-14,17-18,21,33H,5-6,8-10H2,1H3,(H2,26,27)(H,30,32)/t14?,17?,18?,21-,25- | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a | n/a |
Rhône-Poulenc Rorer
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant Sky using poly-GT as substrate and [33P]ATP after 40 mins by beta counting |
Bioorg Med Chem Lett 22: 2784-8 (2012)
Article DOI: 10.1016/j.bmcl.2012.02.087
BindingDB Entry DOI: 10.7270/Q25T3MHR |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase receptor TYRO3
(Homo sapiens (Human)) | BDBM50380766
(CHEMBL2018146)Show SMILES CCn1cc(cn1)-c1cccc(c1)-c1cnc(N)c(n1)C(=O)N[C@H]1C2CC3CC1C[C@](O)(C3)C2 |r,wU:30.34,wD:23.25,TLB:31:30:23:27.25.26,22:23:29:27.26.32,THB:25:24:29:27.26.32,25:26:23.24.33:29,32:26:23:33.30.29,32:30:23:27.25.26,(-9.62,-2.09,;-8.88,-3.44,;-7.34,-3.48,;-6.41,-2.25,;-4.95,-2.76,;-4.99,-4.3,;-6.47,-4.74,;-3.68,-1.88,;-3.66,-.34,;-2.32,.41,;-1,-.37,;-1.01,-1.92,;-2.36,-2.67,;.3,-2.7,;.28,-4.25,;1.6,-5.03,;2.95,-4.28,;4.27,-5.06,;2.96,-2.73,;1.64,-1.95,;4.3,-1.97,;5.63,-2.76,;4.32,-.43,;5.64,.33,;7.15,.72,;8.54,.13,;9.58,1.39,;8.18,1.07,;6.86,1.58,;6.88,3.07,;8.23,3.52,;8.29,5.06,;9.62,2.92,;7.17,2.3,)| Show InChI InChI=1S/C26H30N6O2/c1-2-32-14-20(12-29-32)16-4-3-5-17(8-16)21-13-28-24(27)23(30-21)25(33)31-22-18-6-15-7-19(22)11-26(34,9-15)10-18/h3-5,8,12-15,18-19,22,34H,2,6-7,9-11H2,1H3,(H2,27,28)(H,31,33)/t15?,18?,19?,22-,26- | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a | n/a |
Rhône-Poulenc Rorer
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant Sky using poly-GT as substrate and [33P]ATP after 40 mins by beta counting |
Bioorg Med Chem Lett 22: 2784-8 (2012)
Article DOI: 10.1016/j.bmcl.2012.02.087
BindingDB Entry DOI: 10.7270/Q25T3MHR |
More data for this
Ligand-Target Pair | |
Lysine--tRNA ligase
(Homo sapiens (Human)) | BDBM50390555
(CHEMBL2069344)Show InChI InChI=1S/C21H24N6/c1-16-6-9-23-20(14-16)26-19-5-2-4-18(25-19)17-7-10-24-21(15-17)27-12-3-8-22-11-13-27/h2,4-7,9-10,14-15,22H,3,8,11-13H2,1H3,(H,23,25,26) | PDB
MMDB
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| n/a | n/a | 27 | n/a | n/a | n/a | n/a | n/a | n/a |
Rhône-Poulenc Rorer
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant full-length Syk using poly-GT as substrate after 40 mins by radioactive filtration assay |
Bioorg Med Chem Lett 22: 5419-23 (2012)
Article DOI: 10.1016/j.bmcl.2012.07.045
BindingDB Entry DOI: 10.7270/Q2416Z4V |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase receptor TYRO3
(Homo sapiens (Human)) | BDBM50380784
(CHEMBL2018015)Show SMILES CC(C)(NC(=O)c1nc(cnc1N)-c1cccc(c1)-c1ccc(N)nc1)C1CCNCC1 Show InChI InChI=1S/C24H29N7O/c1-24(2,18-8-10-27-11-9-18)31-23(32)21-22(26)29-14-19(30-21)16-5-3-4-15(12-16)17-6-7-20(25)28-13-17/h3-7,12-14,18,27H,8-11H2,1-2H3,(H2,25,28)(H2,26,29)(H,31,32) | PDB
MMDB
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antibodypedia
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| n/a | n/a | 28 | n/a | n/a | n/a | n/a | n/a | n/a |
Rhône-Poulenc Rorer
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant Sky using poly-GT as substrate and [33P]ATP after 40 mins by beta counting |
Bioorg Med Chem Lett 22: 2784-8 (2012)
Article DOI: 10.1016/j.bmcl.2012.02.087
BindingDB Entry DOI: 10.7270/Q25T3MHR |
More data for this
Ligand-Target Pair | |
Lysine--tRNA ligase
(Homo sapiens (Human)) | BDBM50390565
(CHEMBL2069354)Show SMILES O=C(Nc1cc(Nc2cnccn2)nc(c1)-c1ccnc(c1)N1CCNCC1)c1ccccc1 Show InChI InChI=1S/C25H24N8O/c34-25(18-4-2-1-3-5-18)30-20-15-21(31-22(16-20)32-23-17-27-8-9-28-23)19-6-7-29-24(14-19)33-12-10-26-11-13-33/h1-9,14-17,26H,10-13H2,(H2,28,30,31,32,34) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
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antibodypedia
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| CHEMBL
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PC sid
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Similars
| Article
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| n/a | n/a | 28 | n/a | n/a | n/a | n/a | n/a | n/a |
Rhône-Poulenc Rorer
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant full-length Syk using poly-GT as substrate after 40 mins by radioactive filtration assay |
Bioorg Med Chem Lett 22: 5419-23 (2012)
Article DOI: 10.1016/j.bmcl.2012.07.045
BindingDB Entry DOI: 10.7270/Q2416Z4V |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase receptor TYRO3
(Homo sapiens (Human)) | BDBM50380792
(CHEMBL2018025)Show SMILES CCn1cc(cn1)-c1cccc(c1)-c1cnc(N)c(n1)C(=O)N[C@H]1C2CC3CC1C[C@@](O)(C3)C2 |r,wU:23.25,30.34,TLB:31:30:23:25.27.26,27:28:33:25.26.32,27:26:23.28.29:33,THB:32:26:23:29.30.33,32:30:23:25.27.26,22:23:25.27.26:29.30.33,22:23:33:25.26.32,(-7.92,6.35,;-6.38,6.3,;-5.66,4.94,;-4.19,4.47,;-4.18,2.93,;-5.64,2.45,;-6.56,3.69,;-2.91,2.06,;-1.6,2.88,;-.24,2.16,;-.18,.62,;-1.49,-.2,;-2.85,.52,;-1.43,-1.74,;-2.74,-2.56,;-2.68,-4.09,;-1.31,-4.81,;-1.25,-6.35,;-.01,-3.99,;-.07,-2.45,;1.36,-4.7,;1.42,-6.24,;2.66,-3.87,;4.02,-4.58,;5.19,-3.28,;6.53,-3.74,;7.92,-3.36,;6.93,-4.66,;5.52,-4.13,;5.48,-2.55,;6.49,-1.29,;6.48,.26,;7.9,-1.83,;5.15,-1.79,)| Show InChI InChI=1S/C26H30N6O2/c1-2-32-14-20(12-29-32)16-4-3-5-17(8-16)21-13-28-24(27)23(30-21)25(33)31-22-18-6-15-7-19(22)11-26(34,9-15)10-18/h3-5,8,12-15,18-19,22,34H,2,6-7,9-11H2,1H3,(H2,27,28)(H,31,33)/t15?,18?,19?,22-,26+ | PDB
MMDB
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| n/a | n/a | 30 | n/a | n/a | n/a | n/a | n/a | n/a |
Rhône-Poulenc Rorer
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant Sky using poly-GT as substrate and [33P]ATP after 40 mins by beta counting |
Bioorg Med Chem Lett 22: 2784-8 (2012)
Article DOI: 10.1016/j.bmcl.2012.02.087
BindingDB Entry DOI: 10.7270/Q25T3MHR |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase receptor TYRO3
(Homo sapiens (Human)) | BDBM50380790
(CHEMBL2018023)Show SMILES Cc1cc(cc(c1)-c1cnc(N)c(n1)C(=O)N[C@H]1C2CC3CC1C[C@@](O)(C3)C2)-c1cnn(C)c1 |r,wU:17.18,24.27,TLB:21:22:27:19.20.26,21:20:17.22.23:27,25:24:17:19.21.20,THB:16:17:19.21.20:23.24.27,16:17:27:19.20.26,26:20:17:23.24.27,26:24:17:19.21.20,(.72,-40.49,;-.58,-41.31,;-1.94,-40.59,;-3.25,-41.41,;-3.2,-42.95,;-1.83,-43.68,;-.52,-42.85,;-1.78,-45.21,;-3.08,-46.03,;-3.02,-47.57,;-1.66,-48.29,;-1.6,-49.82,;-.35,-47.46,;-.42,-45.92,;1.01,-48.17,;1.08,-49.71,;2.31,-47.34,;3.68,-48.05,;4.85,-46.75,;6.18,-47.21,;7.57,-46.83,;6.59,-48.13,;5.17,-47.6,;5.13,-46.02,;6.14,-44.76,;6.13,-43.21,;7.55,-45.31,;4.8,-45.27,;-4.62,-40.7,;-6.01,-41.37,;-7.08,-40.26,;-6.36,-38.9,;-7.03,-37.52,;-4.84,-39.17,)| Show InChI InChI=1S/C26H30N6O2/c1-14-3-16(20-11-29-32(2)13-20)7-17(4-14)21-12-28-24(27)23(30-21)25(33)31-22-18-5-15-6-19(22)10-26(34,8-15)9-18/h3-4,7,11-13,15,18-19,22,34H,5-6,8-10H2,1-2H3,(H2,27,28)(H,31,33)/t15?,18?,19?,22-,26+ | PDB
MMDB
KEGG
UniProtKB/SwissProt
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| CHEMBL
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PC sid
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Similars
| Article
PubMed
| n/a | n/a | 30 | n/a | n/a | n/a | n/a | n/a | n/a |
Rhône-Poulenc Rorer
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant Sky using poly-GT as substrate and [33P]ATP after 40 mins by beta counting |
Bioorg Med Chem Lett 22: 2784-8 (2012)
Article DOI: 10.1016/j.bmcl.2012.02.087
BindingDB Entry DOI: 10.7270/Q25T3MHR |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase receptor TYRO3
(Homo sapiens (Human)) | BDBM50380783
(CHEMBL2018014)Show SMILES COc1cncc(c1)-c1cccc(c1)-c1cnc(N)c(n1)C(=O)NC(C)(C)C1CCNCC1 Show InChI InChI=1S/C25H30N6O2/c1-25(2,19-7-9-27-10-8-19)31-24(32)22-23(26)29-15-21(30-22)17-6-4-5-16(11-17)18-12-20(33-3)14-28-13-18/h4-6,11-15,19,27H,7-10H2,1-3H3,(H2,26,29)(H,31,32) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
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antibodypedia
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| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 34 | n/a | n/a | n/a | n/a | n/a | n/a |
Rhône-Poulenc Rorer
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant Sky using poly-GT as substrate and [33P]ATP after 40 mins by beta counting |
Bioorg Med Chem Lett 22: 2784-8 (2012)
Article DOI: 10.1016/j.bmcl.2012.02.087
BindingDB Entry DOI: 10.7270/Q25T3MHR |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase receptor TYRO3
(Homo sapiens (Human)) | BDBM50380799
(CHEMBL2018032)Show SMILES NC(=O)Cn1cc(cn1)-c1cccc(c1)-c1cnc(N)c(n1)C(=O)N[C@H]1C2CC3CC1C[C@@](O)(C3)C2 |r,wU:25.27,32.36,TLB:29:30:35:27.28.34,29:28:25.30.31:35,33:32:25:27.29.28,THB:34:28:25:31.32.35,34:32:25:27.29.28,24:25:27.29.28:31.32.35,24:25:35:27.28.34,(-8.36,6.94,;-7.56,5.63,;-8.29,4.28,;-6.02,5.67,;-5.21,4.35,;-3.75,3.88,;-3.74,2.34,;-5.2,1.86,;-6.12,3.1,;-2.47,1.47,;-1.16,2.29,;.2,1.57,;.26,.03,;-1.05,-.79,;-2.41,-.07,;-.99,-2.33,;-2.3,-3.15,;-2.24,-4.68,;-.87,-5.4,;-.81,-6.94,;.43,-4.58,;.37,-3.04,;1.8,-5.29,;1.86,-6.83,;3.1,-4.46,;4.46,-5.17,;5.63,-3.87,;6.97,-4.33,;8.36,-3.95,;7.37,-5.25,;5.96,-4.72,;5.92,-3.14,;6.93,-1.88,;6.92,-.33,;8.34,-2.42,;5.59,-2.39,)| Show InChI InChI=1S/C26H29N7O3/c27-21(34)13-33-12-19(10-30-33)15-2-1-3-16(6-15)20-11-29-24(28)23(31-20)25(35)32-22-17-4-14-5-18(22)9-26(36,7-14)8-17/h1-3,6,10-12,14,17-18,22,36H,4-5,7-9,13H2,(H2,27,34)(H2,28,29)(H,32,35)/t14?,17?,18?,22-,26+ | PDB
MMDB
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| CHEMBL
PC cid
PC sid
UniChem
Similars
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PubMed
| n/a | n/a | 40 | n/a | n/a | n/a | n/a | n/a | n/a |
Rhône-Poulenc Rorer
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant Sky using poly-GT as substrate and [33P]ATP after 40 mins by beta counting |
Bioorg Med Chem Lett 22: 2784-8 (2012)
Article DOI: 10.1016/j.bmcl.2012.02.087
BindingDB Entry DOI: 10.7270/Q25T3MHR |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase receptor TYRO3
(Homo sapiens (Human)) | BDBM50380795
(CHEMBL2018028)Show SMILES CC(C)n1cc(cn1)-c1cccc(c1)-c1cnc(N)c(n1)C(=O)N[C@H]1C2CC3CC1C[C@@](O)(C3)C2 |r,wU:24.26,31.35,TLB:28:29:34:26.27.33,28:27:24.29.30:34,32:31:24:26.28.27,THB:33:27:24:30.31.34,33:31:24:26.28.27,23:24:26.28.27:30.31.34,23:24:34:26.27.33,(-5.68,6.98,;-6.42,5.63,;-7.96,5.59,;-5.62,4.31,;-4.15,3.84,;-4.14,2.3,;-5.61,1.82,;-6.52,3.06,;-2.87,1.43,;-1.56,2.25,;-.2,1.53,;-.14,-0,;-1.45,-.83,;-2.81,-.11,;-1.39,-2.37,;-2.7,-3.18,;-2.64,-4.72,;-1.27,-5.44,;-1.21,-6.98,;.03,-4.61,;-.03,-3.08,;1.4,-5.33,;1.46,-6.87,;2.7,-4.5,;4.06,-5.21,;5.23,-3.91,;6.57,-4.37,;7.96,-3.99,;6.97,-5.29,;5.56,-4.76,;5.51,-3.17,;6.53,-1.91,;6.51,-.37,;7.93,-2.46,;5.19,-2.42,)| Show InChI InChI=1S/C27H32N6O2/c1-15(2)33-14-21(12-30-33)17-4-3-5-18(8-17)22-13-29-25(28)24(31-22)26(34)32-23-19-6-16-7-20(23)11-27(35,9-16)10-19/h3-5,8,12-16,19-20,23,35H,6-7,9-11H2,1-2H3,(H2,28,29)(H,32,34)/t16?,19?,20?,23-,27+ | PDB
MMDB
KEGG
UniProtKB/SwissProt
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antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 40 | n/a | n/a | n/a | n/a | n/a | n/a |
Rhône-Poulenc Rorer
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant Sky using poly-GT as substrate and [33P]ATP after 40 mins by beta counting |
Bioorg Med Chem Lett 22: 2784-8 (2012)
Article DOI: 10.1016/j.bmcl.2012.02.087
BindingDB Entry DOI: 10.7270/Q25T3MHR |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase receptor TYRO3
(Homo sapiens (Human)) | BDBM50380794
(CHEMBL2018027)Show SMILES CCCn1cc(cn1)-c1cccc(c1)-c1cnc(N)c(n1)C(=O)N[C@H]1C2CC3CC1C[C@@](O)(C3)C2 |r,wU:24.26,31.35,TLB:32:31:24:26.28.27,28:29:34:26.27.33,28:27:24.29.30:34,THB:33:27:24:30.31.34,33:31:24:26.28.27,23:24:26.28.27:30.31.34,23:24:34:26.27.33,(-8.33,5.05,;-7.51,6.35,;-5.97,6.3,;-5.25,4.94,;-3.78,4.47,;-3.77,2.93,;-5.24,2.45,;-6.15,3.69,;-2.5,2.06,;-1.19,2.88,;.17,2.16,;.23,.62,;-1.08,-.2,;-2.44,.52,;-1.02,-1.74,;-2.33,-2.56,;-2.27,-4.09,;-.91,-4.81,;-.85,-6.35,;.4,-3.99,;.34,-2.45,;1.77,-4.7,;1.83,-6.24,;3.07,-3.87,;4.43,-4.58,;5.6,-3.28,;6.94,-3.74,;8.33,-3.36,;7.34,-4.66,;5.92,-4.13,;5.88,-2.55,;6.89,-1.29,;6.88,.26,;8.3,-1.83,;5.56,-1.79,)| Show InChI InChI=1S/C27H32N6O2/c1-2-6-33-15-21(13-30-33)17-4-3-5-18(9-17)22-14-29-25(28)24(31-22)26(34)32-23-19-7-16-8-20(23)12-27(35,10-16)11-19/h3-5,9,13-16,19-20,23,35H,2,6-8,10-12H2,1H3,(H2,28,29)(H,32,34)/t16?,19?,20?,23-,27+ | PDB
MMDB
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UniProtKB/SwissProt
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antibodypedia
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AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 40 | n/a | n/a | n/a | n/a | n/a | n/a |
Rhône-Poulenc Rorer
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant Sky using poly-GT as substrate and [33P]ATP after 40 mins by beta counting |
Bioorg Med Chem Lett 22: 2784-8 (2012)
Article DOI: 10.1016/j.bmcl.2012.02.087
BindingDB Entry DOI: 10.7270/Q25T3MHR |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase receptor TYRO3
(Homo sapiens (Human)) | BDBM50380762
(CHEMBL2018022)Show SMILES Cn1cc(cn1)-c1cccc(c1)-c1cnc(N)c(n1)C(=O)N[C@H]1C2CC3CC1C[C@@](O)(C3)C2 |r,wU:22.24,29.33,TLB:26:27:32:24.25.31,26:25:22.27.28:32,30:29:22:24.26.25,THB:21:22:24.26.25:28.29.32,21:22:32:24.25.31,31:25:22:28.29.32,31:29:22:24.26.25,(12.2,-23.88,;12.88,-25.26,;14.4,-25.53,;14.61,-27.05,;13.23,-27.73,;12.16,-26.62,;15.98,-27.77,;17.29,-26.95,;18.65,-27.67,;18.71,-29.21,;17.4,-30.03,;16.04,-29.31,;17.46,-31.57,;16.15,-32.39,;16.21,-33.92,;17.57,-34.64,;17.64,-36.18,;18.88,-33.81,;18.82,-32.28,;20.25,-34.53,;20.31,-36.07,;21.55,-33.7,;22.91,-34.41,;24.08,-33.11,;25.42,-33.57,;26.81,-33.19,;25.82,-34.49,;24.4,-33.96,;24.36,-32.37,;25.38,-31.12,;25.36,-29.57,;26.78,-31.66,;24.04,-31.62,)| Show InChI InChI=1S/C25H28N6O2/c1-31-13-19(11-28-31)15-3-2-4-16(7-15)20-12-27-23(26)22(29-20)24(32)30-21-17-5-14-6-18(21)10-25(33,8-14)9-17/h2-4,7,11-14,17-18,21,33H,5-6,8-10H2,1H3,(H2,26,27)(H,30,32)/t14?,17?,18?,21-,25+ | PDB
MMDB
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UniProtKB/SwissProt
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antibodypedia
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AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 40 | n/a | n/a | n/a | n/a | n/a | n/a |
Rhône-Poulenc Rorer
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant Sky using poly-GT as substrate and [33P]ATP after 40 mins by beta counting |
Bioorg Med Chem Lett 22: 2784-8 (2012)
Article DOI: 10.1016/j.bmcl.2012.02.087
BindingDB Entry DOI: 10.7270/Q25T3MHR |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase receptor TYRO3
(Homo sapiens (Human)) | BDBM50380782
(CHEMBL2018013)Show SMILES CC(C)(NC(=O)c1nc(cnc1N)-c1cccc2cn[nH]c12)C1CCNCC1 Show InChI InChI=1S/C20H25N7O/c1-20(2,13-6-8-22-9-7-13)26-19(28)17-18(21)23-11-15(25-17)14-5-3-4-12-10-24-27-16(12)14/h3-5,10-11,13,22H,6-9H2,1-2H3,(H2,21,23)(H,24,27)(H,26,28) | PDB
MMDB
KEGG
UniProtKB/SwissProt
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antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 42 | n/a | n/a | n/a | n/a | n/a | n/a |
Rhône-Poulenc Rorer
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant Sky using poly-GT as substrate and [33P]ATP after 40 mins by beta counting |
Bioorg Med Chem Lett 22: 2784-8 (2012)
Article DOI: 10.1016/j.bmcl.2012.02.087
BindingDB Entry DOI: 10.7270/Q25T3MHR |
More data for this
Ligand-Target Pair | |
Lysine--tRNA ligase
(Homo sapiens (Human)) | BDBM50390559
(CHEMBL2069348)Show InChI InChI=1S/C19H20N6/c1-3-15(13-16(4-1)25-11-9-20-10-12-25)17-5-2-6-18(23-17)24-19-14-21-7-8-22-19/h1-8,13-14,20H,9-12H2,(H,22,23,24) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 43 | n/a | n/a | n/a | n/a | n/a | n/a |
Rhône-Poulenc Rorer
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant full-length Syk using poly-GT as substrate after 40 mins by radioactive filtration assay |
Bioorg Med Chem Lett 22: 5419-23 (2012)
Article DOI: 10.1016/j.bmcl.2012.07.045
BindingDB Entry DOI: 10.7270/Q2416Z4V |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase receptor TYRO3
(Homo sapiens (Human)) | BDBM50380791
(CHEMBL2018024)Show SMILES COc1cc(cc(c1)-c1cnc(N)c(n1)C(=O)N[C@H]1C2CC3CC1C[C@@](O)(C3)C2)-c1cnn(C)c1 |r,wU:18.19,25.28,TLB:22:23:28:20.21.27,22:21:18.23.24:28,26:25:18:20.22.21,THB:17:18:20.22.21:24.25.28,17:18:28:20.21.27,27:21:18:24.25.28,27:25:18:20.22.21,(1.83,2.47,;.47,3.18,;-.83,2.36,;-2.19,3.08,;-3.5,2.26,;-3.44,.72,;-2.08,-0,;-.77,.83,;-2.02,-1.54,;-3.33,-2.36,;-3.27,-3.89,;-1.91,-4.61,;-1.85,-6.15,;-.6,-3.78,;-.67,-2.25,;.76,-4.5,;.83,-6.04,;2.06,-3.67,;3.43,-4.38,;4.6,-3.08,;5.94,-3.54,;7.32,-3.16,;6.34,-4.46,;4.92,-3.93,;4.88,-2.34,;5.89,-1.09,;5.88,.46,;7.3,-1.63,;4.56,-1.59,;-4.87,2.98,;-6.25,2.3,;-7.32,3.41,;-6.6,4.77,;-7.28,6.15,;-5.09,4.5,)| Show InChI InChI=1S/C26H30N6O3/c1-32-13-19(11-29-32)15-5-16(7-20(6-15)35-2)21-12-28-24(27)23(30-21)25(33)31-22-17-3-14-4-18(22)10-26(34,8-14)9-17/h5-7,11-14,17-18,22,34H,3-4,8-10H2,1-2H3,(H2,27,28)(H,31,33)/t14?,17?,18?,22-,26+ | PDB
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| n/a | n/a | 50 | n/a | n/a | n/a | n/a | n/a | n/a |
Rhône-Poulenc Rorer
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant Sky using poly-GT as substrate and [33P]ATP after 40 mins by beta counting |
Bioorg Med Chem Lett 22: 2784-8 (2012)
Article DOI: 10.1016/j.bmcl.2012.02.087
BindingDB Entry DOI: 10.7270/Q25T3MHR |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase receptor TYRO3
(Homo sapiens (Human)) | BDBM50380793
(CHEMBL2018026)Show SMILES Nc1ncc(nc1C(=O)N[C@H]1C2CC3CC1C[C@@](O)(C3)C2)-c1cccc(c1)-c1cnn(CC(F)(F)F)c1 |r,wU:10.10,17.19,TLB:18:17:10:12.14.13,14:15:20:12.13.19,14:13:10.15.16:20,THB:19:13:10:16.17.20,19:17:10:12.14.13,9:10:12.14.13:16.17.20,9:10:20:12.13.19,(-.48,-7.03,;-.54,-5.49,;-1.91,-4.77,;-1.96,-3.24,;-.66,-2.42,;.7,-3.13,;.76,-4.66,;2.13,-5.38,;2.19,-6.92,;3.43,-4.55,;4.8,-5.26,;5.96,-3.96,;7.3,-4.42,;8.69,-4.04,;7.7,-5.34,;6.29,-4.81,;6.25,-3.22,;7.26,-1.97,;7.25,-.42,;8.67,-2.51,;5.92,-2.47,;-.71,-.88,;.6,-.06,;.53,1.48,;-.83,2.2,;-2.14,1.38,;-2.08,-.16,;-3.41,2.25,;-4.87,1.77,;-5.78,3.01,;-4.88,4.26,;-5.61,5.62,;-7.15,5.67,;-7.87,7.03,;-7.96,4.37,;-8.69,5.68,;-3.42,3.79,)| Show InChI InChI=1S/C26H27F3N6O2/c27-26(28,29)13-35-12-19(10-32-35)15-2-1-3-16(6-15)20-11-31-23(30)22(33-20)24(36)34-21-17-4-14-5-18(21)9-25(37,7-14)8-17/h1-3,6,10-12,14,17-18,21,37H,4-5,7-9,13H2,(H2,30,31)(H,34,36)/t14?,17?,18?,21-,25+ | PDB
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| n/a | n/a | 50 | n/a | n/a | n/a | n/a | n/a | n/a |
Rhône-Poulenc Rorer
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant Sky using poly-GT as substrate and [33P]ATP after 40 mins by beta counting |
Bioorg Med Chem Lett 22: 2784-8 (2012)
Article DOI: 10.1016/j.bmcl.2012.02.087
BindingDB Entry DOI: 10.7270/Q25T3MHR |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase receptor TYRO3
(Homo sapiens (Human)) | BDBM50380788
(CHEMBL2018020)Show SMILES Nc1ncc(nc1C(=O)N[C@H]1C2CC3CC1C[C@@](O)(C3)C2)-c1cccc(c1)-c1cn[nH]c1 |r,wU:10.10,17.19,TLB:14:15:20:12.13.19,14:13:10.15.16:20,18:17:10:12.14.13,THB:9:10:12.14.13:16.17.20,9:10:20:12.13.19,19:13:10:16.17.20,19:17:10:12.14.13,(31.51,-20.45,;31.45,-18.91,;30.09,-18.19,;30.03,-16.65,;31.33,-15.83,;32.69,-16.54,;32.76,-18.08,;34.12,-18.79,;34.19,-20.33,;35.42,-17.97,;36.79,-18.68,;37.96,-17.37,;39.29,-17.83,;40.68,-17.46,;39.7,-18.76,;38.28,-18.22,;38.24,-16.64,;39.25,-15.38,;39.24,-13.84,;40.66,-15.93,;37.91,-15.89,;31.28,-14.3,;32.59,-13.47,;32.53,-11.93,;31.17,-11.22,;29.86,-12.04,;29.91,-13.58,;28.49,-11.32,;27.1,-12,;26.03,-10.89,;26.75,-9.53,;28.27,-9.79,)| Show InChI InChI=1S/C24H26N6O2/c25-22-21(23(31)30-20-16-4-13-5-17(20)9-24(32,7-13)8-16)29-19(12-26-22)15-3-1-2-14(6-15)18-10-27-28-11-18/h1-3,6,10-13,16-17,20,32H,4-5,7-9H2,(H2,25,26)(H,27,28)(H,30,31)/t13?,16?,17?,20-,24+ | PDB
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| n/a | n/a | 50 | n/a | n/a | n/a | n/a | n/a | n/a |
Rhône-Poulenc Rorer
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant Sky using poly-GT as substrate and [33P]ATP after 40 mins by beta counting |
Bioorg Med Chem Lett 22: 2784-8 (2012)
Article DOI: 10.1016/j.bmcl.2012.02.087
BindingDB Entry DOI: 10.7270/Q25T3MHR |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase receptor TYRO3
(Homo sapiens (Human)) | BDBM50380803
(CHEMBL2018147)Show SMILES Nc1ncc(nc1C(=O)N[C@H]1C2CC3CC1C[C@](O)(C3)C2)-c1cccc(c1)-c1cnn(CCO)c1 |r,wU:17.19,wD:10.10,TLB:18:17:10:14.12.13,9:10:16:14.13.19,THB:12:11:16:14.13.19,12:13:10.11.20:16,19:13:10:20.17.16,19:17:10:14.12.13,(5.04,-5.06,;3.72,-4.28,;2.37,-5.03,;1.05,-4.25,;1.07,-2.7,;2.41,-1.95,;3.73,-2.73,;5.07,-1.97,;6.4,-2.76,;5.09,-.43,;6.41,.33,;7.92,.72,;9.31,.13,;10.35,1.39,;8.95,1.07,;7.63,1.58,;7.65,3.07,;9,3.52,;9.06,5.06,;10.39,2.92,;7.94,2.3,;-.24,-1.92,;-.23,-.37,;-1.55,.41,;-2.89,-.34,;-2.91,-1.88,;-1.59,-2.67,;-4.18,-2.76,;-4.22,-4.3,;-5.7,-4.74,;-6.57,-3.48,;-8.11,-3.44,;-8.85,-2.09,;-10.39,-2.05,;-5.64,-2.25,)| Show InChI InChI=1S/C26H30N6O3/c27-24-23(25(34)31-22-18-6-15-7-19(22)11-26(35,9-15)10-18)30-21(13-28-24)17-3-1-2-16(8-17)20-12-29-32(14-20)4-5-33/h1-3,8,12-15,18-19,22,33,35H,4-7,9-11H2,(H2,27,28)(H,31,34)/t15?,18?,19?,22-,26- | PDB
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| n/a | n/a | 60 | n/a | n/a | n/a | n/a | n/a | n/a |
Rhône-Poulenc Rorer
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant Sky using poly-GT as substrate and [33P]ATP after 40 mins by beta counting |
Bioorg Med Chem Lett 22: 2784-8 (2012)
Article DOI: 10.1016/j.bmcl.2012.02.087
BindingDB Entry DOI: 10.7270/Q25T3MHR |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase receptor TYRO3
(Homo sapiens (Human)) | BDBM50380798
(CHEMBL2018031)Show SMILES Nc1ncc(nc1C(=O)N[C@H]1C2CC3CC1C[C@@](O)(C3)C2)-c1cccc(c1)-c1cnn(CC(O)=O)c1 |r,wU:10.10,17.19,TLB:14:15:20:12.13.19,14:13:10.15.16:20,18:17:10:12.14.13,THB:19:13:10:16.17.20,19:17:10:12.14.13,9:10:12.14.13:16.17.20,9:10:20:12.13.19,(-.81,-6.94,;-.87,-5.4,;-2.24,-4.68,;-2.3,-3.15,;-.99,-2.33,;.37,-3.04,;.43,-4.58,;1.8,-5.29,;1.86,-6.83,;3.1,-4.46,;4.46,-5.17,;5.63,-3.87,;6.97,-4.33,;8.36,-3.95,;7.37,-5.25,;5.96,-4.72,;5.92,-3.14,;6.93,-1.88,;6.92,-.33,;8.34,-2.42,;5.59,-2.39,;-1.05,-.79,;.26,.03,;.2,1.57,;-1.16,2.29,;-2.47,1.47,;-2.41,-.07,;-3.74,2.34,;-5.2,1.86,;-6.12,3.1,;-5.21,4.35,;-6.02,5.67,;-7.56,5.63,;-8.36,6.94,;-8.29,4.28,;-3.75,3.88,)| Show InChI InChI=1S/C26H28N6O4/c27-24-23(25(35)31-22-17-4-14-5-18(22)9-26(36,7-14)8-17)30-20(11-28-24)16-3-1-2-15(6-16)19-10-29-32(12-19)13-21(33)34/h1-3,6,10-12,14,17-18,22,36H,4-5,7-9,13H2,(H2,27,28)(H,31,35)(H,33,34)/t14?,17?,18?,22-,26+ | PDB
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| n/a | n/a | 60 | n/a | n/a | n/a | n/a | n/a | n/a |
Rhône-Poulenc Rorer
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant Sky using poly-GT as substrate and [33P]ATP after 40 mins by beta counting |
Bioorg Med Chem Lett 22: 2784-8 (2012)
Article DOI: 10.1016/j.bmcl.2012.02.087
BindingDB Entry DOI: 10.7270/Q25T3MHR |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase receptor TYRO3
(Homo sapiens (Human)) | BDBM50380796
(CHEMBL2018029)Show SMILES Nc1ncc(nc1C(=O)N[C@H]1C2CC3CC1C[C@@](O)(C3)C2)-c1cccc(c1)-c1cnn(CCO)c1 |r,wU:10.10,17.19,TLB:14:15:20:12.13.19,14:13:10.15.16:20,18:17:10:12.14.13,THB:19:13:10:16.17.20,19:17:10:12.14.13,9:10:12.14.13:16.17.20,9:10:20:12.13.19,(-.81,-6.94,;-.87,-5.4,;-2.24,-4.68,;-2.3,-3.15,;-.99,-2.33,;.37,-3.04,;.43,-4.58,;1.8,-5.29,;1.86,-6.83,;3.1,-4.46,;4.46,-5.17,;5.63,-3.87,;6.97,-4.33,;8.36,-3.95,;7.37,-5.25,;5.96,-4.72,;5.92,-3.14,;6.93,-1.88,;6.92,-.33,;8.34,-2.42,;5.59,-2.39,;-1.05,-.79,;.26,.03,;.2,1.57,;-1.16,2.29,;-2.47,1.47,;-2.41,-.07,;-3.74,2.34,;-5.2,1.86,;-6.12,3.1,;-5.21,4.35,;-6.02,5.67,;-7.56,5.63,;-8.36,6.94,;-3.75,3.88,)| Show InChI InChI=1S/C26H30N6O3/c27-24-23(25(34)31-22-18-6-15-7-19(22)11-26(35,9-15)10-18)30-21(13-28-24)17-3-1-2-16(8-17)20-12-29-32(14-20)4-5-33/h1-3,8,12-15,18-19,22,33,35H,4-7,9-11H2,(H2,27,28)(H,31,34)/t15?,18?,19?,22-,26+ | PDB
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| n/a | n/a | 60 | n/a | n/a | n/a | n/a | n/a | n/a |
Rhône-Poulenc Rorer
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant Sky using poly-GT as substrate and [33P]ATP after 40 mins by beta counting |
Bioorg Med Chem Lett 22: 2784-8 (2012)
Article DOI: 10.1016/j.bmcl.2012.02.087
BindingDB Entry DOI: 10.7270/Q25T3MHR |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase receptor TYRO3
(Homo sapiens (Human)) | BDBM50380779
(CHEMBL2018010)Show SMILES CC(C)(NC(=O)c1nc(cnc1N)-c1cccc(OC(F)(F)F)c1)C1CCNCC1 Show InChI InChI=1S/C20H24F3N5O2/c1-19(2,13-6-8-25-9-7-13)28-18(29)16-17(24)26-11-15(27-16)12-4-3-5-14(10-12)30-20(21,22)23/h3-5,10-11,13,25H,6-9H2,1-2H3,(H2,24,26)(H,28,29) | PDB
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| n/a | n/a | 60 | n/a | n/a | n/a | n/a | n/a | n/a |
Rhône-Poulenc Rorer
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant Sky using poly-GT as substrate and [33P]ATP after 40 mins by beta counting |
Bioorg Med Chem Lett 22: 2784-8 (2012)
Article DOI: 10.1016/j.bmcl.2012.02.087
BindingDB Entry DOI: 10.7270/Q25T3MHR |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase receptor TYRO3
(Homo sapiens (Human)) | BDBM50380800
(CHEMBL2018143)Show SMILES COCCn1cc(cn1)-c1cccc(c1)-c1cnc(N)c(n1)C(=O)N[C@H]1C2CC3CC1C[C@@](O)(C3)C2 |r,wU:25.27,32.36,TLB:29:30:35:27.28.34,29:28:25.30.31:35,33:32:25:27.29.28,THB:34:28:25:31.32.35,34:32:25:27.29.28,24:25:27.29.28:31.32.35,24:25:35:27.28.34,(-9.1,4.88,;-7.56,4.91,;-6.82,6.27,;-5.28,6.3,;-4.48,4.99,;-3.01,4.52,;-3,2.98,;-4.47,2.5,;-5.38,3.74,;-1.73,2.11,;-.42,2.92,;.94,2.21,;1,.67,;-.31,-.16,;-1.67,.57,;-.25,-1.69,;-1.56,-2.51,;-1.5,-4.05,;-.14,-4.77,;-.08,-6.3,;1.17,-3.94,;1.11,-2.4,;2.54,-4.65,;2.6,-6.19,;3.84,-3.83,;5.2,-4.53,;6.37,-3.23,;7.71,-3.69,;9.1,-3.31,;8.11,-4.61,;6.69,-4.08,;6.65,-2.5,;7.66,-1.24,;7.65,.31,;9.07,-1.79,;6.33,-1.75,)| Show InChI InChI=1S/C27H32N6O3/c1-36-6-5-33-15-21(13-30-33)17-3-2-4-18(9-17)22-14-29-25(28)24(31-22)26(34)32-23-19-7-16-8-20(23)12-27(35,10-16)11-19/h2-4,9,13-16,19-20,23,35H,5-8,10-12H2,1H3,(H2,28,29)(H,32,34)/t16?,19?,20?,23-,27+ | PDB
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| n/a | n/a | 60 | n/a | n/a | n/a | n/a | n/a | n/a |
Rhône-Poulenc Rorer
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant Sky using poly-GT as substrate and [33P]ATP after 40 mins by beta counting |
Bioorg Med Chem Lett 22: 2784-8 (2012)
Article DOI: 10.1016/j.bmcl.2012.02.087
BindingDB Entry DOI: 10.7270/Q25T3MHR |
More data for this
Ligand-Target Pair | |
Lysine--tRNA ligase
(Homo sapiens (Human)) | BDBM50390558
(CHEMBL2069347)Show InChI InChI=1S/C18H19N7/c1-2-15(23-16(3-1)24-17-13-20-6-7-21-17)14-4-5-22-18(12-14)25-10-8-19-9-11-25/h1-7,12-13,19H,8-11H2,(H,21,23,24) | PDB
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| n/a | n/a | 62 | n/a | n/a | n/a | n/a | n/a | n/a |
Rhône-Poulenc Rorer
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant full-length Syk using poly-GT as substrate after 40 mins by radioactive filtration assay |
Bioorg Med Chem Lett 22: 5419-23 (2012)
Article DOI: 10.1016/j.bmcl.2012.07.045
BindingDB Entry DOI: 10.7270/Q2416Z4V |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase receptor TYRO3
(Homo sapiens (Human)) | BDBM50380785
(CHEMBL2018016)Show SMILES Cn1cc(cn1)-c1cccc(c1)-c1cnc(N)c(n1)C(=O)NC(C)(C)C1CCNCC1 Show InChI InChI=1S/C23H29N7O/c1-23(2,18-7-9-25-10-8-18)29-22(31)20-21(24)26-13-19(28-20)16-6-4-5-15(11-16)17-12-27-30(3)14-17/h4-6,11-14,18,25H,7-10H2,1-3H3,(H2,24,26)(H,29,31) | PDB
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PC cid
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Similars
| Article
PubMed
| n/a | n/a | 67 | n/a | n/a | n/a | n/a | n/a | n/a |
Rhône-Poulenc Rorer
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant Sky using poly-GT as substrate and [33P]ATP after 40 mins by beta counting |
Bioorg Med Chem Lett 22: 2784-8 (2012)
Article DOI: 10.1016/j.bmcl.2012.02.087
BindingDB Entry DOI: 10.7270/Q25T3MHR |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase receptor TYRO3
(Homo sapiens (Human)) | BDBM50380797
(CHEMBL2018030)Show SMILES NCCn1cc(cn1)-c1cccc(c1)-c1cnc(N)c(n1)C(=O)N[C@H]1C2CC3CC1C[C@@](O)(C3)C2 |r,wU:24.26,31.35,TLB:28:29:34:26.27.33,28:27:24.29.30:34,32:31:24:26.28.27,THB:33:27:24:30.31.34,33:31:24:26.28.27,23:24:26.28.27:30.31.34,23:24:34:26.27.33,(-8.36,6.94,;-7.56,5.63,;-6.02,5.67,;-5.21,4.35,;-3.75,3.88,;-3.74,2.34,;-5.2,1.86,;-6.12,3.1,;-2.47,1.47,;-1.16,2.29,;.2,1.57,;.26,.03,;-1.05,-.79,;-2.41,-.07,;-.99,-2.33,;-2.3,-3.15,;-2.24,-4.68,;-.87,-5.4,;-.81,-6.94,;.43,-4.58,;.37,-3.04,;1.8,-5.29,;1.86,-6.83,;3.1,-4.46,;4.46,-5.17,;5.63,-3.87,;6.97,-4.33,;8.36,-3.95,;7.37,-5.25,;5.96,-4.72,;5.92,-3.14,;6.93,-1.88,;6.92,-.33,;8.34,-2.42,;5.59,-2.39,)| Show InChI InChI=1S/C26H31N7O2/c27-4-5-33-14-20(12-30-33)16-2-1-3-17(8-16)21-13-29-24(28)23(31-21)25(34)32-22-18-6-15-7-19(22)11-26(35,9-15)10-18/h1-3,8,12-15,18-19,22,35H,4-7,9-11,27H2,(H2,28,29)(H,32,34)/t15?,18?,19?,22-,26+ | PDB
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| n/a | n/a | 80 | n/a | n/a | n/a | n/a | n/a | n/a |
Rhône-Poulenc Rorer
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant Sky using poly-GT as substrate and [33P]ATP after 40 mins by beta counting |
Bioorg Med Chem Lett 22: 2784-8 (2012)
Article DOI: 10.1016/j.bmcl.2012.02.087
BindingDB Entry DOI: 10.7270/Q25T3MHR |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase receptor TYRO3
(Homo sapiens (Human)) | BDBM50380781
(CHEMBL2018012)Show SMILES CC(C)(NC(=O)c1nc(cnc1N)-c1ccc2cn[nH]c2c1)C1CCNCC1 Show InChI InChI=1S/C20H25N7O/c1-20(2,14-5-7-22-8-6-14)26-19(28)17-18(21)23-11-16(25-17)12-3-4-13-10-24-27-15(13)9-12/h3-4,9-11,14,22H,5-8H2,1-2H3,(H2,21,23)(H,24,27)(H,26,28) | PDB
MMDB
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PC sid
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| n/a | n/a | 85 | n/a | n/a | n/a | n/a | n/a | n/a |
Rhône-Poulenc Rorer
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant Sky using poly-GT as substrate and [33P]ATP after 40 mins by beta counting |
Bioorg Med Chem Lett 22: 2784-8 (2012)
Article DOI: 10.1016/j.bmcl.2012.02.087
BindingDB Entry DOI: 10.7270/Q25T3MHR |
More data for this
Ligand-Target Pair | |
Lysine--tRNA ligase
(Homo sapiens (Human)) | BDBM50390570
(CHEMBL2069337)Show InChI InChI=1S/C19H21N5/c1-14-8-10-22-19(12-14)24-18-7-3-6-17(23-18)15-4-2-5-16(13-15)21-11-9-20/h2-8,10,12-13,21H,9,11,20H2,1H3,(H,22,23,24) | PDB
MMDB
Reactome pathway
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| n/a | n/a | 91 | n/a | n/a | n/a | n/a | n/a | n/a |
Rhône-Poulenc Rorer
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant full-length Syk using poly-GT as substrate after 40 mins by radioactive filtration assay |
Bioorg Med Chem Lett 22: 5419-23 (2012)
Article DOI: 10.1016/j.bmcl.2012.07.045
BindingDB Entry DOI: 10.7270/Q2416Z4V |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase receptor TYRO3
(Homo sapiens (Human)) | BDBM50380780
(CHEMBL2018011)Show SMILES CC(C)(NC(=O)c1nc(cnc1N)-c1ccc2CC(=O)Nc2c1)C1CCNCC1 Show InChI InChI=1S/C21H26N6O2/c1-21(2,14-5-7-23-8-6-14)27-20(29)18-19(22)24-11-16(26-18)12-3-4-13-10-17(28)25-15(13)9-12/h3-4,9,11,14,23H,5-8,10H2,1-2H3,(H2,22,24)(H,25,28)(H,27,29) | PDB
MMDB
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antibodypedia
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PC cid
PC sid
UniChem
| Article
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| n/a | n/a | 100 | n/a | n/a | n/a | n/a | n/a | n/a |
Rhône-Poulenc Rorer
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant Sky using poly-GT as substrate and [33P]ATP after 40 mins by beta counting |
Bioorg Med Chem Lett 22: 2784-8 (2012)
Article DOI: 10.1016/j.bmcl.2012.02.087
BindingDB Entry DOI: 10.7270/Q25T3MHR |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase receptor TYRO3
(Homo sapiens (Human)) | BDBM50380786
(CHEMBL2018018)Show SMILES Nc1ncc(nc1C(=O)N[C@H]1C2CC3CC1C[C@@](O)(C3)C2)-c1ccc2cn[nH]c2c1 |r,wU:10.10,17.19,TLB:14:15:20:12.13.19,14:13:10.15.16:20,18:17:10:12.14.13,THB:9:10:12.14.13:16.17.20,9:10:20:12.13.19,19:13:10:16.17.20,19:17:10:12.14.13,(-3.17,-5.41,;-3.23,-3.88,;-4.59,-3.16,;-4.65,-1.62,;-3.34,-.8,;-1.98,-1.51,;-1.92,-3.05,;-.56,-3.76,;-.49,-5.3,;.74,-2.94,;2.11,-3.64,;3.28,-2.34,;4.61,-2.8,;6,-2.42,;5.02,-3.72,;3.6,-3.19,;3.56,-1.61,;4.57,-.35,;4.56,1.19,;5.98,-.9,;3.24,-.86,;-3.4,.73,;-2.09,1.56,;-2.15,3.1,;-3.51,3.81,;-3.89,5.31,;-5.43,5.41,;-6,3.98,;-4.82,2.99,;-4.76,1.45,)| Show InChI InChI=1S/C22H24N6O2/c23-20-19(26-17(10-24-20)12-1-2-13-9-25-28-16(13)5-12)21(29)27-18-14-3-11-4-15(18)8-22(30,6-11)7-14/h1-2,5,9-11,14-15,18,30H,3-4,6-8H2,(H2,23,24)(H,25,28)(H,27,29)/t11?,14?,15?,18-,22+ | PDB
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PC sid
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PubMed
| n/a | n/a | 100 | n/a | n/a | n/a | n/a | n/a | n/a |
Rhône-Poulenc Rorer
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant Sky using poly-GT as substrate and [33P]ATP after 40 mins by beta counting |
Bioorg Med Chem Lett 22: 2784-8 (2012)
Article DOI: 10.1016/j.bmcl.2012.02.087
BindingDB Entry DOI: 10.7270/Q25T3MHR |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase receptor TYRO3
(Homo sapiens (Human)) | BDBM50380787
(CHEMBL2018019)Show SMILES Nc1ccc(cn1)-c1cccc(c1)-c1cnc(N)c(n1)C(=O)N[C@H]1C2CC3CC1C[C@@](O)(C3)C2 |r,wU:23.25,30.34,TLB:27:28:33:25.26.32,27:26:23.28.29:33,31:30:23:25.27.26,THB:22:23:25.27.26:29.30.33,22:23:33:25.26.32,32:26:23:29.30.33,32:30:23:25.27.26,(5.49,-8.4,;6.86,-9.12,;8.16,-8.3,;9.52,-9.03,;9.58,-10.57,;8.28,-11.38,;6.92,-10.67,;10.93,-11.28,;12.24,-10.46,;13.6,-11.18,;13.66,-12.72,;12.35,-13.54,;10.99,-12.82,;12.41,-15.08,;11.1,-15.9,;11.16,-17.43,;12.53,-18.15,;12.59,-19.69,;13.83,-17.33,;13.77,-15.79,;15.2,-18.04,;15.26,-19.58,;16.5,-17.21,;17.86,-17.92,;19.03,-16.62,;20.37,-17.08,;21.76,-16.7,;20.77,-18,;19.36,-17.47,;19.32,-15.89,;20.33,-14.63,;20.32,-13.08,;21.74,-15.17,;18.99,-15.13,)| Show InChI InChI=1S/C26H28N6O2/c27-21-5-4-17(12-29-21)15-2-1-3-16(8-15)20-13-30-24(28)23(31-20)25(33)32-22-18-6-14-7-19(22)11-26(34,9-14)10-18/h1-5,8,12-14,18-19,22,34H,6-7,9-11H2,(H2,27,29)(H2,28,30)(H,32,33)/t14?,18?,19?,22-,26+ | PDB
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PubMed
| n/a | n/a | 110 | n/a | n/a | n/a | n/a | n/a | n/a |
Rhône-Poulenc Rorer
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant Sky using poly-GT as substrate and [33P]ATP after 40 mins by beta counting |
Bioorg Med Chem Lett 22: 2784-8 (2012)
Article DOI: 10.1016/j.bmcl.2012.02.087
BindingDB Entry DOI: 10.7270/Q25T3MHR |
More data for this
Ligand-Target Pair | |
Lysine--tRNA ligase
(Homo sapiens (Human)) | BDBM50390554
(CHEMBL2069343)Show SMILES Cc1ccnc(Nc2cccc(n2)-c2ccnc(c2)N2CCC(N)CC2)c1 Show InChI InChI=1S/C21H24N6/c1-15-5-9-23-20(13-15)26-19-4-2-3-18(25-19)16-6-10-24-21(14-16)27-11-7-17(22)8-12-27/h2-6,9-10,13-14,17H,7-8,11-12,22H2,1H3,(H,23,25,26) | PDB
MMDB
Reactome pathway
KEGG
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| CHEMBL
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PC sid
UniChem
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PubMed
| n/a | n/a | 114 | n/a | n/a | n/a | n/a | n/a | n/a |
Rhône-Poulenc Rorer
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant full-length Syk using poly-GT as substrate after 40 mins by radioactive filtration assay |
Bioorg Med Chem Lett 22: 5419-23 (2012)
Article DOI: 10.1016/j.bmcl.2012.07.045
BindingDB Entry DOI: 10.7270/Q2416Z4V |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase receptor TYRO3
(Homo sapiens (Human)) | BDBM50380771
(CHEMBL2018002)Show SMILES CC(C)(NC(=O)c1nc(cnc1N)-c1cccc(NS(C)(=O)=O)c1)C1CCNCC1 Show InChI InChI=1S/C20H28N6O3S/c1-20(2,14-7-9-22-10-8-14)25-19(27)17-18(21)23-12-16(24-17)13-5-4-6-15(11-13)26-30(3,28)29/h4-6,11-12,14,22,26H,7-10H2,1-3H3,(H2,21,23)(H,25,27) | PDB
MMDB
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| CHEMBL
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PC sid
UniChem
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PubMed
| n/a | n/a | 120 | n/a | n/a | n/a | n/a | n/a | n/a |
Rhône-Poulenc Rorer
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant Sky using poly-GT as substrate and [33P]ATP after 40 mins by beta counting |
Bioorg Med Chem Lett 22: 2784-8 (2012)
Article DOI: 10.1016/j.bmcl.2012.02.087
BindingDB Entry DOI: 10.7270/Q25T3MHR |
More data for this
Ligand-Target Pair | |
Lysine--tRNA ligase
(Homo sapiens (Human)) | BDBM50390548
(CHEMBL2069340)Show InChI InChI=1S/C19H20N4/c1-14-9-11-21-19(12-14)23-18-7-3-6-17(22-18)16-5-2-4-15(13-16)8-10-20/h2-7,9,11-13H,8,10,20H2,1H3,(H,21,22,23) | PDB
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Reactome pathway
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PubMed
| n/a | n/a | 160 | n/a | n/a | n/a | n/a | n/a | n/a |
Rhône-Poulenc Rorer
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant full-length Syk using poly-GT as substrate after 40 mins by radioactive filtration assay |
Bioorg Med Chem Lett 22: 5419-23 (2012)
Article DOI: 10.1016/j.bmcl.2012.07.045
BindingDB Entry DOI: 10.7270/Q2416Z4V |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Rattus norvegicus (rat)) | BDBM50226429
(CHEMBL237354 | [L-arginyl]-N-(2,4-dichlorophenethy...)Show SMILES [#7]-[#6@@H](-[#6]-[#6]-[#6]\[#7]=[#6](\[#7])-[#7])-[#6](=O)-[#7](-[#6]-[#6]-c1ccc(Cl)cc1Cl)-[#6]-[#6](=O)-[#7]-[#6]-[#6]-c1ccc(Cl)cc1Cl Show InChI InChI=1S/C24H30Cl4N6O2/c25-17-5-3-15(19(27)12-17)7-10-32-22(35)14-34(11-8-16-4-6-18(26)13-20(16)28)23(36)21(29)2-1-9-33-24(30)31/h3-6,12-13,21H,1-2,7-11,14,29H2,(H,32,35)(H4,30,31,33)/t21-/m0/s1 | PDB
MMDB
Reactome pathway
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| CHEMBL
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PubMed
| n/a | n/a | 170 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Barcelona
Curated by ChEMBL
| Assay Description
Blockade of capsaicin-activated rat TRPV1 channel expressed in Xenopus oocytes |
J Med Chem 50: 6133-43 (2007)
Article DOI: 10.1021/jm070612v
BindingDB Entry DOI: 10.7270/Q2FQ9WC0 |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase receptor TYRO3
(Homo sapiens (Human)) | BDBM50380801
(CHEMBL2018144)Show SMILES Nc1ncc(nc1C(=O)N[C@H]1C2CC3CC1C[C@](O)(C3)C2)-c1ccc2cn[nH]c2c1 |r,wU:17.19,wD:10.10,TLB:9:10:16:14.13.19,18:17:10:14.12.13,THB:12:11:16:14.13.19,12:13:10.11.20:16,19:13:10:20.17.16,19:17:10:14.12.13,(2.49,-5.06,;1.16,-4.28,;-.18,-5.03,;-1.5,-4.25,;-1.48,-2.7,;-.15,-1.95,;1.18,-2.73,;2.52,-1.97,;3.84,-2.76,;2.53,-.43,;3.85,.33,;5.36,.72,;6.76,.13,;7.79,1.39,;6.39,1.07,;5.07,1.58,;5.09,3.07,;6.45,3.52,;6.5,5.06,;7.83,2.92,;5.39,2.3,;-2.8,-1.92,;-2.78,-.37,;-4.11,.41,;-5.45,-.34,;-6.91,.15,;-7.83,-1.08,;-6.94,-2.34,;-5.47,-1.88,;-4.15,-2.67,)| Show InChI InChI=1S/C22H24N6O2/c23-20-19(26-17(10-24-20)12-1-2-13-9-25-28-16(13)5-12)21(29)27-18-14-3-11-4-15(18)8-22(30,6-11)7-14/h1-2,5,9-11,14-15,18,30H,3-4,6-8H2,(H2,23,24)(H,25,28)(H,27,29)/t11?,14?,15?,18-,22- | PDB
MMDB
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PubMed
| n/a | n/a | 180 | n/a | n/a | n/a | n/a | n/a | n/a |
Rhône-Poulenc Rorer
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant Sky using poly-GT as substrate and [33P]ATP after 40 mins by beta counting |
Bioorg Med Chem Lett 22: 2784-8 (2012)
Article DOI: 10.1016/j.bmcl.2012.02.087
BindingDB Entry DOI: 10.7270/Q25T3MHR |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Rattus norvegicus (rat)) | BDBM50226436
(CHEMBL401228 | [L-arginyl]-[N-(2,4-dichloropheneth...)Show SMILES N[C@@H](CCCN=C(N)N)C(=O)N(CCc1ccc(Cl)cc1Cl)CC(=O)N(CCc1c[nH]c2ccccc12)CC(N)=O |wD:1.0,(-7.03,-18.3,;-5.69,-19.07,;-5.69,-20.61,;-7.03,-21.38,;-7.03,-22.92,;-8.36,-23.69,;-8.36,-25.23,;-9.7,-26,;-7.03,-26,;-4.36,-18.31,;-4.36,-16.77,;-3.03,-19.08,;-3.03,-20.62,;-1.69,-21.39,;-1.69,-22.93,;-3.03,-23.69,;-3.03,-25.23,;-1.7,-26,;-1.69,-27.54,;-.36,-25.22,;-.36,-23.68,;.97,-22.91,;-1.69,-18.31,;-.36,-19.08,;-.36,-20.62,;.97,-18.31,;.97,-16.77,;-.36,-16,;-.36,-14.46,;.88,-13.56,;.41,-12.09,;-1.13,-12.09,;-2.16,-10.94,;-3.67,-11.27,;-4.15,-12.74,;-3.11,-13.88,;-1.61,-13.56,;2.31,-19.08,;3.64,-18.31,;4.98,-19.08,;3.64,-16.77,)| Show InChI InChI=1S/C28H36Cl2N8O3/c29-20-8-7-18(22(30)14-20)9-13-38(27(41)23(31)5-3-11-35-28(33)34)17-26(40)37(16-25(32)39)12-10-19-15-36-24-6-2-1-4-21(19)24/h1-2,4,6-8,14-15,23,36H,3,5,9-13,16-17,31H2,(H2,32,39)(H4,33,34,35)/t23-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
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GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 180 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Barcelona
Curated by ChEMBL
| Assay Description
Blockade of capsaicin-activated rat TRPV1 channel expressed in Xenopus oocytes |
J Med Chem 50: 6133-43 (2007)
Article DOI: 10.1021/jm070612v
BindingDB Entry DOI: 10.7270/Q2FQ9WC0 |
More data for this
Ligand-Target Pair | |
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