BindingDB logo
myBDB logout
Compile Data Set for Download or QSAR

Found 405 hits with Last Name = 'mosley' and Initial = 'c'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))		BDBM50304090
PNG
(CHEMBL594615 | N-(4-(3-(2-(3,4-Dichlorophenylamino...)
Show SMILES CS(=O)(=O)Nc1ccc(CCCNCCNc2ccc(Cl)c(Cl)c2)cc1
Show InChI InChI=1S/C18H23Cl2N3O2S/c1-26(24,25)23-15-6-4-14(5-7-15)3-2-10-21-11-12-22-16-8-9-17(19)18(20)13-16/h4-9,13,21-23H,2-3,10-12H2,1H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
 14n/an/an/an/an/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Displacement of [3H]astemizole from human recombinant ERG expressed in HEK293 cells

Bioorg Med Chem 17: 6463-80 (2009)


Article DOI: 10.1016/j.bmc.2009.05.085
BindingDB Entry DOI: 10.7270/Q2M61KB5
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B


(Rattus norvegicus (Rat))		BDBM50304085
PNG
(CHEMBL607819 | N-(2-(3,4-Dichlorophenylamino)ethyl...)
Show SMILES CS(=O)(=O)Nc1ccc(OCC(=O)NCCNc2ccc(Cl)c(Cl)c2)cc1
Show InChI InChI=1S/C17H19Cl2N3O4S/c1-27(24,25)22-12-2-5-14(6-3-12)26-11-17(23)21-9-8-20-13-4-7-15(18)16(19)10-13/h2-7,10,20,22H,8-9,11H2,1H3,(H,21,23)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
 119n/an/an/an/an/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Displacement of [3H]ifenprodil form NR2B receptor in Wistar rat cerebral cortex membrane

Bioorg Med Chem 17: 6463-80 (2009)


Article DOI: 10.1016/j.bmc.2009.05.085
BindingDB Entry DOI: 10.7270/Q2M61KB5
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))		BDBM50304088
PNG
(CHEMBL596046 | N-(4-(2-(2-(3,4-Dichlorophenylamino...)
Show SMILES CS(=O)(=O)Nc1ccc(OCCNCCNc2ccc(Cl)c(Cl)c2)cc1
Show InChI InChI=1S/C17H21Cl2N3O3S/c1-26(23,24)22-13-2-5-15(6-3-13)25-11-10-20-8-9-21-14-4-7-16(18)17(19)12-14/h2-7,12,20-22H,8-11H2,1H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
 300n/an/an/an/an/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Displacement of [3H]astemizole from human recombinant ERG expressed in HEK293 cells

Bioorg Med Chem 17: 6463-80 (2009)


Article DOI: 10.1016/j.bmc.2009.05.085
BindingDB Entry DOI: 10.7270/Q2M61KB5
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B


(Rattus norvegicus (Rat))		BDBM50304087
PNG
(CHEMBL596036 | N-(4-(2-(3-(3,4-Dichlorophenyl)-2-o...)
Show SMILES CS(=O)(=O)Nc1ccc(OCCN2CCN(C2=O)c2ccc(Cl)c(Cl)c2)cc1
Show InChI InChI=1S/C18H19Cl2N3O4S/c1-28(25,26)21-13-2-5-15(6-3-13)27-11-10-22-8-9-23(18(22)24)14-4-7-16(19)17(20)12-14/h2-7,12,21H,8-11H2,1H3
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents
Article
PubMed
 300n/an/an/an/an/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Displacement of [3H]ifenprodil form NR2B receptor in Wistar rat cerebral cortex membrane

Bioorg Med Chem 17: 6463-80 (2009)


Article DOI: 10.1016/j.bmc.2009.05.085
BindingDB Entry DOI: 10.7270/Q2M61KB5
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))		BDBM168618
PNG
(US9079852, Table F, Compound 3)
Show SMILES CS(=O)(=O)Nc1ccc(OC[C@@H](O)CN2CCN(CC2)c2ccc(Cl)cc2)cc1 |r|
Show InChI InChI=1S/C20H26ClN3O4S/c1-29(26,27)22-17-4-8-20(9-5-17)28-15-19(25)14-23-10-12-24(13-11-23)18-6-2-16(21)3-7-18/h2-9,19,22,25H,10-15H2,1H3/t19-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
 553n/an/an/an/an/an/an/an/a



Emory University; NeurOp, Inc.

US Patent


Assay Description
Compounds were evaluated for binding to the human ether-a-go-go potassium channel (hERG) expressed in HEK293 cells by displacement of 3[H]-astemizole...

US Patent US9079852 (2015)


BindingDB Entry DOI: 10.7270/Q2K35SF5
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B


(Rattus norvegicus (Rat))		BDBM50304086
PNG
(CHEMBL594417 | N-(4-(2-(4-(3,4-Dichlorophenyl)pipe...)
Show SMILES CS(=O)(=O)Nc1ccc(OCC(=O)N2CCN(CC2)c2ccc(Cl)c(Cl)c2)cc1
Show InChI InChI=1S/C19H21Cl2N3O4S/c1-29(26,27)22-14-2-5-16(6-3-14)28-13-19(25)24-10-8-23(9-11-24)15-4-7-17(20)18(21)12-15/h2-7,12,22H,8-11,13H2,1H3
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
 817n/an/an/an/an/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Displacement of [3H]ifenprodil form NR2B receptor in Wistar rat cerebral cortex membrane

Bioorg Med Chem 17: 6463-80 (2009)


Article DOI: 10.1016/j.bmc.2009.05.085
BindingDB Entry DOI: 10.7270/Q2M61KB5
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))		BDBM168620
PNG
(US9079852, Table F, Compound 5)
Show SMILES O[C@H](COc1ccc2[nH]ncc2c1)CN1CCN(CC1)c1ccc(Cl)cc1 |r|
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
 1.00E+3n/an/an/an/an/an/an/an/a



Emory University; NeurOp, Inc.

US Patent


Assay Description
Compounds were evaluated for binding to the human ether-a-go-go potassium channel (hERG) expressed in HEK293 cells by displacement of 3[H]-astemizole...

US Patent US9079852 (2015)


BindingDB Entry DOI: 10.7270/Q2K35SF5
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))		BDBM168617
PNG
(US9079852, Table F, Compound 2)
Show SMILES O[C@H](COc1ccc2[nH]c(=O)oc2c1)CN1CCN(CC1)c1ccc(Cl)cc1 |r|
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
 1.60E+3n/an/an/an/an/an/an/an/a



Emory University; NeurOp, Inc.

US Patent


Assay Description
Compounds were evaluated for binding to the human ether-a-go-go potassium channel (hERG) expressed in HEK293 cells by displacement of 3[H]-astemizole...

US Patent US9079852 (2015)


BindingDB Entry DOI: 10.7270/Q2K35SF5
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))		BDBM50304091
PNG
(CHEMBL609857 | N-(3,4-Dichlorocinnamyl)-3-(4-(meth...)
Show SMILES CS(=O)(=O)Nc1ccc(CCC(=O)NC\C=C\c2ccc(Cl)c(Cl)c2)cc1
Show InChI InChI=1S/C19H20Cl2N2O3S/c1-27(25,26)23-16-8-4-14(5-9-16)7-11-19(24)22-12-2-3-15-6-10-17(20)18(21)13-15/h2-6,8-10,13,23H,7,11-12H2,1H3,(H,22,24)/b3-2+
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
 3.00E+3n/an/an/an/an/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Displacement of [3H]astemizole from human recombinant ERG expressed in HEK293 cells

Bioorg Med Chem 17: 6463-80 (2009)


Article DOI: 10.1016/j.bmc.2009.05.085
BindingDB Entry DOI: 10.7270/Q2M61KB5
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))		BDBM50304089
PNG
(CHEMBL595318 | N-(2-(3,4-Dichlorophenylamino)ethyl...)
Show SMILES CS(=O)(=O)Nc1ccc(CCC(=O)NCCNc2ccc(Cl)c(Cl)c2)cc1
Show InChI InChI=1S/C18H21Cl2N3O3S/c1-27(25,26)23-14-5-2-13(3-6-14)4-9-18(24)22-11-10-21-15-7-8-16(19)17(20)12-15/h2-3,5-8,12,21,23H,4,9-11H2,1H3,(H,22,24)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
 4.62E+3n/an/an/an/an/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Displacement of [3H]astemizole from human recombinant ERG expressed in HEK293 cells

Bioorg Med Chem 17: 6463-80 (2009)


Article DOI: 10.1016/j.bmc.2009.05.085
BindingDB Entry DOI: 10.7270/Q2M61KB5
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))		BDBM168626
PNG
(US9079852, Table F, Compound 11)
Show SMILES O[C@H](COc1ccc2NC(=O)CCc2c1)CN1CCN(CC1)c1ccc(Cl)cc1 |r|
Show InChI InChI=1S/C22H26ClN3O3/c23-17-2-4-18(5-3-17)26-11-9-25(10-12-26)14-19(27)15-29-20-6-7-21-16(13-20)1-8-22(28)24-21/h2-7,13,19,27H,1,8-12,14-15H2,(H,24,28)/t19-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
 5.00E+3n/an/an/an/an/an/an/an/a



Emory University; NeurOp, Inc.

US Patent


Assay Description
Compounds were evaluated for binding to the human ether-a-go-go potassium channel (hERG) expressed in HEK293 cells by displacement of 3[H]-astemizole...

US Patent US9079852 (2015)


BindingDB Entry DOI: 10.7270/Q2K35SF5
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))		BDBM168625
PNG
(US9079852, Table F, Compound 10)
Show SMILES O[C@H](COc1ccc2[nH]c(=S)[nH]c2c1)CN1CCN(CC1)c1ccc(Cl)cc1 |r|
Show InChI InChI=1S/C20H21ClN4O2S/c21-14-1-3-15(4-2-14)25-9-7-24(8-10-25)12-16(26)13-27-17-5-6-18-19(11-17)23-20(28)22-18/h1-6,11,16,26H,7-10,12-13H2/t16-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
 7.50E+3n/an/an/an/an/an/an/an/a



Emory University; NeurOp, Inc.

US Patent


Assay Description
Compounds were evaluated for binding to the human ether-a-go-go potassium channel (hERG) expressed in HEK293 cells by displacement of 3[H]-astemizole...

US Patent US9079852 (2015)


BindingDB Entry DOI: 10.7270/Q2K35SF5
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))		BDBM168622
PNG
(US9079852, Table F, Compound 7)
Show SMILES O[C@H](COc1ccc2[nH]c(=O)[nH]c2c1)CN1CCN(CC1)c1ccc(Cl)cc1 |r|
Show InChI InChI=1S/C20H21ClN4O3/c21-14-1-3-15(4-2-14)25-9-7-24(8-10-25)12-16(26)13-28-17-5-6-18-19(11-17)23-20(27)22-18/h1-6,11,16,26H,7-10,12-13H2/t16-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
 7.50E+3n/an/an/an/an/an/an/an/a



Emory University; NeurOp, Inc.

US Patent


Assay Description
Compounds were evaluated for binding to the human ether-a-go-go potassium channel (hERG) expressed in HEK293 cells by displacement of 3[H]-astemizole...

US Patent US9079852 (2015)


BindingDB Entry DOI: 10.7270/Q2K35SF5
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))		BDBM168621
PNG
(US9079852, Table F, Compound 6)
Show SMILES O[C@H](COc1ccc2[nH]c(=O)ccc2c1)CN1CCN(CC1)c1ccc(Cl)cc1 |r|
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
 7.50E+3n/an/an/an/an/an/an/an/a



Emory University; NeurOp, Inc.

US Patent


Assay Description
Compounds were evaluated for binding to the human ether-a-go-go potassium channel (hERG) expressed in HEK293 cells by displacement of 3[H]-astemizole...

US Patent US9079852 (2015)


BindingDB Entry DOI: 10.7270/Q2K35SF5
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))		BDBM168624
PNG
(US9079852, Table F, Compound 9)
Show SMILES O[C@H](COc1ccc2NC(=O)Cc2c1)CN1CCN(CC1)c1ccc(Cl)cc1 |r|
Show InChI InChI=1S/C21H24ClN3O3/c22-16-1-3-17(4-2-16)25-9-7-24(8-10-25)13-18(26)14-28-19-5-6-20-15(11-19)12-21(27)23-20/h1-6,11,18,26H,7-10,12-14H2,(H,23,27)/t18-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
 1.00E+4n/an/an/an/an/an/an/an/a



Emory University; NeurOp, Inc.

US Patent


Assay Description
Compounds were evaluated for binding to the human ether-a-go-go potassium channel (hERG) expressed in HEK293 cells by displacement of 3[H]-astemizole...

US Patent US9079852 (2015)


BindingDB Entry DOI: 10.7270/Q2K35SF5
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))		BDBM168619
PNG
(US9079852, Table F, Compound 4)
Show SMILES NC(=O)Nc1ccc(OC[C@@H](O)CN2CCN(CC2)c2ccc(Cl)cc2)cc1 |r|
Show InChI InChI=1S/C20H25ClN4O3/c21-15-1-5-17(6-2-15)25-11-9-24(10-12-25)13-18(26)14-28-19-7-3-16(4-8-19)23-20(22)27/h1-8,18,26H,9-14H2,(H3,22,23,27)/t18-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
 1.30E+4n/an/an/an/an/an/an/an/a



Emory University; NeurOp, Inc.

US Patent


Assay Description
Compounds were evaluated for binding to the human ether-a-go-go potassium channel (hERG) expressed in HEK293 cells by displacement of 3[H]-astemizole...

US Patent US9079852 (2015)


BindingDB Entry DOI: 10.7270/Q2K35SF5
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))		BDBM168616
PNG
(US9079852, Table F, Compound 1)
Show SMILES O[C@H](COc1ccc(O)cc1)CN1CCN(CC1)c1ccc(Cl)cc1 |r|
Show InChI InChI=1S/C19H23ClN2O3/c20-15-1-3-16(4-2-15)22-11-9-21(10-12-22)13-18(24)14-25-19-7-5-17(23)6-8-19/h1-8,18,23-24H,9-14H2/t18-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
 3.90E+4n/an/an/an/an/an/an/an/a



Emory University; NeurOp, Inc.

US Patent


Assay Description
Compounds were evaluated for binding to the human ether-a-go-go potassium channel (hERG) expressed in HEK293 cells by displacement of 3[H]-astemizole...

US Patent US9079852 (2015)


BindingDB Entry DOI: 10.7270/Q2K35SF5
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1/2B


(Rattus norvegicus (Rat)-RAT)		BDBM50304085
PNG
(CHEMBL607819 | N-(2-(3,4-Dichlorophenylamino)ethyl...)
Show SMILES CS(=O)(=O)Nc1ccc(OCC(=O)NCCNc2ccc(Cl)c(Cl)c2)cc1
Show InChI InChI=1S/C17H19Cl2N3O4S/c1-27(24,25)22-12-2-5-14(6-3-12)26-11-17(23)21-9-8-20-13-4-7-15(18)16(19)10-13/h2-7,10,20,22H,8-9,11H2,1H3,(H,21,23)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 57n/an/an/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Antagonist activity at rat recombinant NR1/NR2B receptor expressed in frog oocytes assessed as inhibition of glutamate/glycine-induced current by two...

Bioorg Med Chem 17: 6463-80 (2009)


Article DOI: 10.1016/j.bmc.2009.05.085
BindingDB Entry DOI: 10.7270/Q2M61KB5
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1/2B


(Rattus norvegicus (Rat)-RAT)		BDBM50304085
PNG
(CHEMBL607819 | N-(2-(3,4-Dichlorophenylamino)ethyl...)
Show SMILES CS(=O)(=O)Nc1ccc(OCC(=O)NCCNc2ccc(Cl)c(Cl)c2)cc1
Show InChI InChI=1S/C17H19Cl2N3O4S/c1-27(24,25)22-12-2-5-14(6-3-12)26-11-17(23)21-9-8-20-13-4-7-15(18)16(19)10-13/h2-7,10,20,22H,8-9,11H2,1H3,(H,21,23)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 57n/an/an/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Antagonist activity at wild type rat NR1/NR2B receptor expressed in Xenopus laevis oocytes assessed as inhibition of glutamate/glycine-induced curren...

Bioorg Med Chem 17: 6463-80 (2009)


Article DOI: 10.1016/j.bmc.2009.05.085
BindingDB Entry DOI: 10.7270/Q2M61KB5
More data for this
Ligand-Target Pair
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))		BDBM168626
PNG
(US9079852, Table F, Compound 11)
Show SMILES O[C@H](COc1ccc2NC(=O)CCc2c1)CN1CCN(CC1)c1ccc(Cl)cc1 |r|
Show InChI InChI=1S/C22H26ClN3O3/c23-17-2-4-18(5-3-17)26-11-9-25(10-12-26)14-19(27)15-29-20-6-7-21-16(13-20)1-8-22(28)24-21/h2-7,13,19,27H,1,8-12,14-15H2,(H,24,28)/t19-/m0/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 100n/an/an/an/an/an/a



Emory University; NeurOp, Inc.

US Patent


Assay Description
Binding to the rat alpha-1 adrenergic receptor in rat brain membranes was determined by displacement of 3[H]-prazosin (P. Greengrass and R. Bremner; ...

US Patent US9079852 (2015)


BindingDB Entry DOI: 10.7270/Q2K35SF5
More data for this
Ligand-Target Pair
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))		BDBM168624
PNG
(US9079852, Table F, Compound 9)
Show SMILES O[C@H](COc1ccc2NC(=O)Cc2c1)CN1CCN(CC1)c1ccc(Cl)cc1 |r|
Show InChI InChI=1S/C21H24ClN3O3/c22-16-1-3-17(4-2-16)25-9-7-24(8-10-25)13-18(26)14-28-19-5-6-20-15(11-19)12-21(27)23-20/h1-6,11,18,26H,7-10,12-14H2,(H,23,27)/t18-/m0/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 100n/an/an/an/an/an/a



Emory University; NeurOp, Inc.

US Patent


Assay Description
Binding to the rat alpha-1 adrenergic receptor in rat brain membranes was determined by displacement of 3[H]-prazosin (P. Greengrass and R. Bremner; ...

US Patent US9079852 (2015)


BindingDB Entry DOI: 10.7270/Q2K35SF5
More data for this
Ligand-Target Pair
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))		BDBM168625
PNG
(US9079852, Table F, Compound 10)
Show SMILES O[C@H](COc1ccc2[nH]c(=S)[nH]c2c1)CN1CCN(CC1)c1ccc(Cl)cc1 |r|
Show InChI InChI=1S/C20H21ClN4O2S/c21-14-1-3-15(4-2-14)25-9-7-24(8-10-25)12-16(26)13-27-17-5-6-18-19(11-17)23-20(28)22-18/h1-6,11,16,26H,7-10,12-13H2/t16-/m0/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 150n/an/an/an/an/an/a



Emory University; NeurOp, Inc.

US Patent


Assay Description
Binding to the rat alpha-1 adrenergic receptor in rat brain membranes was determined by displacement of 3[H]-prazosin (P. Greengrass and R. Bremner; ...

US Patent US9079852 (2015)


BindingDB Entry DOI: 10.7270/Q2K35SF5
More data for this
Ligand-Target Pair
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))		BDBM168620
PNG
(US9079852, Table F, Compound 5)
Show SMILES O[C@H](COc1ccc2[nH]ncc2c1)CN1CCN(CC1)c1ccc(Cl)cc1 |r|
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 300n/an/an/an/an/an/a



Emory University; NeurOp, Inc.

US Patent


Assay Description
Binding to the rat alpha-1 adrenergic receptor in rat brain membranes was determined by displacement of 3[H]-prazosin (P. Greengrass and R. Bremner; ...

US Patent US9079852 (2015)


BindingDB Entry DOI: 10.7270/Q2K35SF5
More data for this
Ligand-Target Pair
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))		BDBM168619
PNG
(US9079852, Table F, Compound 4)
Show SMILES NC(=O)Nc1ccc(OC[C@@H](O)CN2CCN(CC2)c2ccc(Cl)cc2)cc1 |r|
Show InChI InChI=1S/C20H25ClN4O3/c21-15-1-5-17(6-2-15)25-11-9-24(10-12-25)13-18(26)14-28-19-7-3-16(4-8-19)23-20(22)27/h1-8,18,26H,9-14H2,(H3,22,23,27)/t18-/m0/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 340n/an/an/an/an/an/a



Emory University; NeurOp, Inc.

US Patent


Assay Description
Binding to the rat alpha-1 adrenergic receptor in rat brain membranes was determined by displacement of 3[H]-prazosin (P. Greengrass and R. Bremner; ...

US Patent US9079852 (2015)


BindingDB Entry DOI: 10.7270/Q2K35SF5
More data for this
Ligand-Target Pair
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))		BDBM168621
PNG
(US9079852, Table F, Compound 6)
Show SMILES O[C@H](COc1ccc2[nH]c(=O)ccc2c1)CN1CCN(CC1)c1ccc(Cl)cc1 |r|
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 350n/an/an/an/an/an/a



Emory University; NeurOp, Inc.

US Patent


Assay Description
Binding to the rat alpha-1 adrenergic receptor in rat brain membranes was determined by displacement of 3[H]-prazosin (P. Greengrass and R. Bremner; ...

US Patent US9079852 (2015)


BindingDB Entry DOI: 10.7270/Q2K35SF5
More data for this
Ligand-Target Pair
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))		BDBM168622
PNG
(US9079852, Table F, Compound 7)
Show SMILES O[C@H](COc1ccc2[nH]c(=O)[nH]c2c1)CN1CCN(CC1)c1ccc(Cl)cc1 |r|
Show InChI InChI=1S/C20H21ClN4O3/c21-14-1-3-15(4-2-14)25-9-7-24(8-10-25)12-16(26)13-28-17-5-6-18-19(11-17)23-20(27)22-18/h1-6,11,16,26H,7-10,12-13H2/t16-/m0/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 350n/an/an/an/an/an/a



Emory University; NeurOp, Inc.

US Patent


Assay Description
Binding to the rat alpha-1 adrenergic receptor in rat brain membranes was determined by displacement of 3[H]-prazosin (P. Greengrass and R. Bremner; ...

US Patent US9079852 (2015)


BindingDB Entry DOI: 10.7270/Q2K35SF5
More data for this
Ligand-Target Pair
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))		BDBM168618
PNG
(US9079852, Table F, Compound 3)
Show SMILES CS(=O)(=O)Nc1ccc(OC[C@@H](O)CN2CCN(CC2)c2ccc(Cl)cc2)cc1 |r|
Show InChI InChI=1S/C20H26ClN3O4S/c1-29(26,27)22-17-4-8-20(9-5-17)28-15-19(25)14-23-10-12-24(13-11-23)18-6-2-16(21)3-7-18/h2-9,19,22,25H,10-15H2,1H3/t19-/m0/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 350n/an/an/an/an/an/a



Emory University; NeurOp, Inc.

US Patent


Assay Description
Binding to the rat alpha-1 adrenergic receptor in rat brain membranes was determined by displacement of 3[H]-prazosin (P. Greengrass and R. Bremner; ...

US Patent US9079852 (2015)


BindingDB Entry DOI: 10.7270/Q2K35SF5
More data for this
Ligand-Target Pair
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))		BDBM168617
PNG
(US9079852, Table F, Compound 2)
Show SMILES O[C@H](COc1ccc2[nH]c(=O)oc2c1)CN1CCN(CC1)c1ccc(Cl)cc1 |r|
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 620n/an/an/an/an/an/a



Emory University; NeurOp, Inc.

US Patent


Assay Description
Binding to the rat alpha-1 adrenergic receptor in rat brain membranes was determined by displacement of 3[H]-prazosin (P. Greengrass and R. Bremner; ...

US Patent US9079852 (2015)


BindingDB Entry DOI: 10.7270/Q2K35SF5
More data for this
Ligand-Target Pair
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))		BDBM168616
PNG
(US9079852, Table F, Compound 1)
Show SMILES O[C@H](COc1ccc(O)cc1)CN1CCN(CC1)c1ccc(Cl)cc1 |r|
Show InChI InChI=1S/C19H23ClN2O3/c20-15-1-3-16(4-2-15)22-11-9-21(10-12-22)13-18(24)14-25-19-7-5-17(23)6-8-19/h1-8,18,23-24H,9-14H2/t18-/m0/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 720n/an/an/an/an/an/a



Emory University; NeurOp, Inc.

US Patent


Assay Description
Binding to the rat alpha-1 adrenergic receptor in rat brain membranes was determined by displacement of 3[H]-prazosin (P. Greengrass and R. Bremner; ...

US Patent US9079852 (2015)


BindingDB Entry DOI: 10.7270/Q2K35SF5
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1/2C


(RAT-Rattus norvegicus (Rat))		BDBM50324399
PNG
((E)-4-(6-iodo-2-(3-nitrostyryl)-4-oxoquinazolin-3(...)
Show SMILES OC(=O)c1ccc(cc1)-n1c(\C=C\c2cccc(c2)[N+]([O-])=O)nc2ccc(I)cc2c1=O
Show InChI InChI=1S/C23H14IN3O5/c24-16-7-10-20-19(13-16)22(28)26(17-8-5-15(6-9-17)23(29)30)21(25-20)11-4-14-2-1-3-18(12-14)27(31)32/h1-13H,(H,29,30)/b11-4+
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 1.00E+3n/an/an/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Antagonist activity at rat recombinant NR1-NR2C receptor expressed in Xenopus oocytes at holding potential of -40mV by two-electrode voltage-clamp el...

J Med Chem 53: 5476-90 (2010)


Article DOI: 10.1021/jm100027p
BindingDB Entry DOI: 10.7270/Q2DR2VQF
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1/2C


(RAT-Rattus norvegicus (Rat))		BDBM50324405
PNG
((E)-4-(2-(3-Nitrostyryl)-4-oxobenzo[g]quinazolin-3...)
Show SMILES OC(=O)c1ccc(cc1)-n1c(\C=C\c2cccc(c2)[N+]([O-])=O)nc2cc3ccccc3cc2c1=O
Show InChI InChI=1S/C27H17N3O5/c31-26-23-15-19-5-1-2-6-20(19)16-24(23)28-25(13-8-17-4-3-7-22(14-17)30(34)35)29(26)21-11-9-18(10-12-21)27(32)33/h1-16H,(H,32,33)/b13-8+
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

Similars
Article
PubMed
n/an/a 2.00E+3n/an/an/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Antagonist activity at rat recombinant NR1-NR2C receptor expressed in Xenopus oocytes at holding potential of -40mV by two-electrode voltage-clamp el...

J Med Chem 53: 5476-90 (2010)


Article DOI: 10.1021/jm100027p
BindingDB Entry DOI: 10.7270/Q2DR2VQF
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1/2C


(RAT-Rattus norvegicus (Rat))		BDBM50324404
PNG
((E)-4-(2-(3-Nitrostyryl)-4-oxo-6-phenylquinazolin-...)
Show SMILES OC(=O)c1ccc(cc1)-n1c(\C=C\c2cccc(c2)[N+]([O-])=O)nc2ccc(cc2c1=O)-c1ccccc1
Show InChI InChI=1S/C29H19N3O5/c33-28-25-18-22(20-6-2-1-3-7-20)12-15-26(25)30-27(16-9-19-5-4-8-24(17-19)32(36)37)31(28)23-13-10-21(11-14-23)29(34)35/h1-18H,(H,34,35)/b16-9+
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

Similars
Article
PubMed
n/an/a 2.00E+3n/an/an/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Antagonist activity at rat recombinant NR1-NR2C receptor expressed in Xenopus oocytes at holding potential of -40mV by two-electrode voltage-clamp el...

J Med Chem 53: 5476-90 (2010)


Article DOI: 10.1021/jm100027p
BindingDB Entry DOI: 10.7270/Q2DR2VQF
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1/2C


(RAT-Rattus norvegicus (Rat))		BDBM50324397
PNG
((E)-4-(6-Fluoro-2-(3-nitrostyryl)-4-oxoquinazolin-...)
Show SMILES OC(=O)c1ccc(cc1)-n1c(\C=C\c2cccc(c2)[N+]([O-])=O)nc2ccc(F)cc2c1=O
Show InChI InChI=1S/C23H14FN3O5/c24-16-7-10-20-19(13-16)22(28)26(17-8-5-15(6-9-17)23(29)30)21(25-20)11-4-14-2-1-3-18(12-14)27(31)32/h1-13H,(H,29,30)/b11-4+
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 2.00E+3n/an/an/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Antagonist activity at rat recombinant NR1-NR2C receptor expressed in Xenopus oocytes at holding potential of -40mV by two-electrode voltage-clamp el...

J Med Chem 53: 5476-90 (2010)


Article DOI: 10.1021/jm100027p
BindingDB Entry DOI: 10.7270/Q2DR2VQF
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1/2C


(RAT-Rattus norvegicus (Rat))		BDBM50324398
PNG
((E)-4-(6-Bromo-2-(3-nitrostyryl)-4-oxoquinazolin-3...)
Show SMILES OC(=O)c1ccc(cc1)-n1c(\C=C\c2cccc(c2)[N+]([O-])=O)nc2ccc(Br)cc2c1=O
Show InChI InChI=1S/C23H14BrN3O5/c24-16-7-10-20-19(13-16)22(28)26(17-8-5-15(6-9-17)23(29)30)21(25-20)11-4-14-2-1-3-18(12-14)27(31)32/h1-13H,(H,29,30)/b11-4+
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 2.00E+3n/an/an/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Antagonist activity at rat recombinant NR1-NR2C receptor expressed in Xenopus oocytes at holding potential of -40mV by two-electrode voltage-clamp el...

J Med Chem 53: 5476-90 (2010)


Article DOI: 10.1021/jm100027p
BindingDB Entry DOI: 10.7270/Q2DR2VQF
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1/2C


(RAT-Rattus norvegicus (Rat))		BDBM50324428
PNG
((E)-3-(6-Iodo-2-(3-nitrostyryl)-4-oxoquinazolin-3(...)
Show SMILES OC(=O)c1cccc(c1)-n1c(\C=C\c2cccc(c2)[N+]([O-])=O)nc2ccc(I)cc2c1=O
Show InChI InChI=1S/C23H14IN3O5/c24-16-8-9-20-19(13-16)22(28)26(17-5-2-4-15(12-17)23(29)30)21(25-20)10-7-14-3-1-6-18(11-14)27(31)32/h1-13H,(H,29,30)/b10-7+
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 2.00E+3n/an/an/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Antagonist activity at rat recombinant NR1-NR2C receptor expressed in Xenopus oocytes at holding potential of -40mV by two-electrode voltage-clamp el...

J Med Chem 53: 5476-90 (2010)


Article DOI: 10.1021/jm100027p
BindingDB Entry DOI: 10.7270/Q2DR2VQF
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1/2C


(RAT-Rattus norvegicus (Rat))		BDBM50324392
PNG
((E)-4-(6-Chloro-2-(3-nitrostyryl)-4-oxoquinazolin-...)
Show SMILES OC(=O)c1ccc(cc1)-n1c(\C=C\c2cccc(c2)[N+]([O-])=O)nc2ccc(Cl)cc2c1=O
Show InChI InChI=1S/C23H14ClN3O5/c24-16-7-10-20-19(13-16)22(28)26(17-8-5-15(6-9-17)23(29)30)21(25-20)11-4-14-2-1-3-18(12-14)27(31)32/h1-13H,(H,29,30)/b11-4+
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 2.00E+3n/an/an/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Antagonist activity at rat recombinant NR1-NR2C receptor expressed in Xenopus oocytes at holding potential of -40mV by two-electrode voltage-clamp el...

J Med Chem 53: 5476-90 (2010)


Article DOI: 10.1021/jm100027p
BindingDB Entry DOI: 10.7270/Q2DR2VQF
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1/2C


(RAT-Rattus norvegicus (Rat))		BDBM50324426
PNG
((E)-4-(6-iodo-2-(4-nitrostyryl)-4-oxoquinazolin-3(...)
Show SMILES OC(=O)c1ccc(cc1)-n1c(\C=C\c2ccc(cc2)[N+]([O-])=O)nc2ccc(I)cc2c1=O
Show InChI InChI=1S/C23H14IN3O5/c24-16-6-11-20-19(13-16)22(28)26(17-9-4-15(5-10-17)23(29)30)21(25-20)12-3-14-1-7-18(8-2-14)27(31)32/h1-13H,(H,29,30)/b12-3+
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Patents

Similars
Article
PubMed
n/an/a 2.00E+3n/an/an/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Antagonist activity at rat recombinant NR1-NR2C receptor expressed in Xenopus oocytes at holding potential of -40mV by two-electrode voltage-clamp el...

J Med Chem 53: 5476-90 (2010)


Article DOI: 10.1021/jm100027p
BindingDB Entry DOI: 10.7270/Q2DR2VQF
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1/2B


(Rattus norvegicus (Rat)-RAT)		BDBM50324404
PNG
((E)-4-(2-(3-Nitrostyryl)-4-oxo-6-phenylquinazolin-...)
Show SMILES OC(=O)c1ccc(cc1)-n1c(\C=C\c2cccc(c2)[N+]([O-])=O)nc2ccc(cc2c1=O)-c1ccccc1
Show InChI InChI=1S/C29H19N3O5/c33-28-25-18-22(20-6-2-1-3-7-20)12-15-26(25)30-27(16-9-19-5-4-8-24(17-19)32(36)37)31(28)23-13-10-21(11-14-23)29(34)35/h1-18H,(H,34,35)/b16-9+
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

Similars
Article
PubMed
n/an/a 3.00E+3n/an/an/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Antagonist activity at rat recombinant NR1-NR2B receptor expressed in Xenopus oocytes at holding potential of -40mV by two-electrode voltage-clamp el...

J Med Chem 53: 5476-90 (2010)


Article DOI: 10.1021/jm100027p
BindingDB Entry DOI: 10.7270/Q2DR2VQF
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1/2C


(RAT-Rattus norvegicus (Rat))		BDBM50324445
PNG
((E)-6-iodo-3-(2-methoxyphenyl)-2-(2-(pyridin-3-yl)...)
Show SMILES COc1ccccc1-n1c(\C=C\c2cccnc2)nc2ccc(I)cc2c1=O |(9.99,5.86,;9.99,4.32,;11.33,3.56,;12.66,4.34,;14.01,3.58,;14.01,2.04,;12.68,1.26,;11.34,2.03,;10.01,1.26,;10.02,-.29,;11.36,-1.06,;11.36,-2.6,;12.69,-3.36,;14.01,-2.58,;15.35,-3.34,;15.35,-4.89,;14.02,-5.66,;12.69,-4.9,;8.68,-1.07,;7.35,-.3,;6,-1.07,;4.67,-.3,;4.67,1.24,;3.34,2.01,;6,2.01,;7.34,1.24,;8.67,2.03,;8.66,3.57,)|
Show InChI InChI=1S/C22H16IN3O2/c1-28-20-7-3-2-6-19(20)26-21(11-8-15-5-4-12-24-14-15)25-18-10-9-16(23)13-17(18)22(26)27/h2-14H,1H3/b11-8+
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 3.00E+3n/an/an/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Antagonist activity at rat recombinant NR1-NR2C receptor expressed in Xenopus oocytes at holding potential of -40mV by two-electrode voltage-clamp el...

J Med Chem 53: 5476-90 (2010)


Article DOI: 10.1021/jm100027p
BindingDB Entry DOI: 10.7270/Q2DR2VQF
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1/2C


(RAT-Rattus norvegicus (Rat))		BDBM50324409
PNG
((E)-4-(2-(3-Nitrostyryl)-4-oxo-6-propylquinazolin-...)
Show SMILES CCCc1ccc2nc(\C=C\c3cccc(c3)[N+]([O-])=O)n(-c3ccc(cc3)C(O)=O)c(=O)c2c1
Show InChI InChI=1S/C26H21N3O5/c1-2-4-17-7-13-23-22(16-17)25(30)28(20-11-9-19(10-12-20)26(31)32)24(27-23)14-8-18-5-3-6-21(15-18)29(33)34/h3,5-16H,2,4H2,1H3,(H,31,32)/b14-8+
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 3.00E+3n/an/an/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Antagonist activity at rat recombinant NR1-NR2C receptor expressed in Xenopus oocytes at holding potential of -40mV by two-electrode voltage-clamp el...

J Med Chem 53: 5476-90 (2010)


Article DOI: 10.1021/jm100027p
BindingDB Entry DOI: 10.7270/Q2DR2VQF
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1/2C


(RAT-Rattus norvegicus (Rat))		BDBM50324411
PNG
(4-(2-(3-Nitrostyryl)-4-oxo-6-styrylquinazolin-3(4H...)
Show SMILES OC(=O)c1ccc(cc1)-n1c(\C=C\c2cccc(c2)[N+]([O-])=O)nc2ccc(\C=C\c3ccccc3)cc2c1=O
Show InChI InChI=1S/C31H21N3O5/c35-30-27-20-23(10-9-21-5-2-1-3-6-21)11-17-28(27)32-29(18-12-22-7-4-8-26(19-22)34(38)39)33(30)25-15-13-24(14-16-25)31(36)37/h1-20H,(H,36,37)/b10-9+,18-12+
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 4.00E+3n/an/an/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Antagonist activity at rat recombinant NR1-NR2C receptor expressed in Xenopus oocytes at holding potential of -40mV by two-electrode voltage-clamp el...

J Med Chem 53: 5476-90 (2010)


Article DOI: 10.1021/jm100027p
BindingDB Entry DOI: 10.7270/Q2DR2VQF
More data for this
Ligand-Target Pair
Glutamate receptor 1


(Rattus norvegicus (Rat))		BDBM50324405
PNG
((E)-4-(2-(3-Nitrostyryl)-4-oxobenzo[g]quinazolin-3...)
Show SMILES OC(=O)c1ccc(cc1)-n1c(\C=C\c2cccc(c2)[N+]([O-])=O)nc2cc3ccccc3cc2c1=O
Show InChI InChI=1S/C27H17N3O5/c31-26-23-15-19-5-1-2-6-20(19)16-24(23)28-25(13-8-17-4-3-7-22(14-17)30(34)35)29(26)21-11-9-18(10-12-21)27(32)33/h1-16H,(H,32,33)/b13-8+
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

Similars
Article
PubMed
n/an/a 4.00E+3n/an/an/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Antagonist activity at rat recombinant GLuR1 expressed in Xenopus oocytes assessed as inhibition of glutamate-induced current by two-electrode voltag...

J Med Chem 53: 5476-90 (2010)


Article DOI: 10.1021/jm100027p
BindingDB Entry DOI: 10.7270/Q2DR2VQF
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1/2C


(RAT-Rattus norvegicus (Rat))		BDBM50324473
PNG
((E)-3-(2-methoxyphenyl)-2-(2-nitrostyryl)quinazoli...)
Show SMILES COc1ccccc1-n1c(\C=C\c2ccccc2[N+]([O-])=O)nc2ccccc2c1=O |(33.08,.19,;31.74,.96,;31.74,2.5,;33.07,3.27,;33.06,4.81,;31.73,5.58,;30.4,4.8,;30.4,3.27,;29.07,2.5,;29.08,.94,;30.41,.19,;30.42,-1.37,;31.76,-2.13,;33.07,-1.35,;34.41,-2.12,;34.42,-3.66,;33.09,-4.43,;31.75,-3.67,;30.42,-4.44,;29.08,-3.67,;30.42,-5.98,;27.74,.16,;26.4,.93,;25.05,.16,;23.72,.93,;23.72,2.47,;25.05,3.25,;26.39,2.48,;27.72,3.27,;27.71,4.81,)|
Show InChI InChI=1S/C23H17N3O4/c1-30-21-13-7-6-12-20(21)25-22(24-18-10-4-3-9-17(18)23(25)27)15-14-16-8-2-5-11-19(16)26(28)29/h2-15H,1H3/b15-14+
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 4.00E+3n/an/an/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Antagonist activity at rat recombinant NR1-NR2C receptor expressed in Xenopus oocytes at holding potential of -40mV by two-electrode voltage-clamp el...

J Med Chem 53: 5476-90 (2010)


Article DOI: 10.1021/jm100027p
BindingDB Entry DOI: 10.7270/Q2DR2VQF
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1/2A


(Rattus norvegicus (Rat)-RAT)		BDBM50324473
PNG
((E)-3-(2-methoxyphenyl)-2-(2-nitrostyryl)quinazoli...)
Show SMILES COc1ccccc1-n1c(\C=C\c2ccccc2[N+]([O-])=O)nc2ccccc2c1=O |(33.08,.19,;31.74,.96,;31.74,2.5,;33.07,3.27,;33.06,4.81,;31.73,5.58,;30.4,4.8,;30.4,3.27,;29.07,2.5,;29.08,.94,;30.41,.19,;30.42,-1.37,;31.76,-2.13,;33.07,-1.35,;34.41,-2.12,;34.42,-3.66,;33.09,-4.43,;31.75,-3.67,;30.42,-4.44,;29.08,-3.67,;30.42,-5.98,;27.74,.16,;26.4,.93,;25.05,.16,;23.72,.93,;23.72,2.47,;25.05,3.25,;26.39,2.48,;27.72,3.27,;27.71,4.81,)|
Show InChI InChI=1S/C23H17N3O4/c1-30-21-13-7-6-12-20(21)25-22(24-18-10-4-3-9-17(18)23(25)27)15-14-16-8-2-5-11-19(16)26(28)29/h2-15H,1H3/b15-14+
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 4.00E+3n/an/an/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Antagonist activity at rat recombinant NR1-NR2A receptor expressed in Xenopus oocytes at holding potential of -40mV by two-electrode voltage-clamp el...

J Med Chem 53: 5476-90 (2010)


Article DOI: 10.1021/jm100027p
BindingDB Entry DOI: 10.7270/Q2DR2VQF
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1/2C


(RAT-Rattus norvegicus (Rat))		BDBM50324410
PNG
((E)-4-(2-(3-nitrostyryl)-4-oxo-6-(thiophen-2-yl)qu...)
Show SMILES OC(=O)c1ccc(cc1)-n1c(\C=C\c2cccc(c2)[N+]([O-])=O)nc2ccc(cc2c1=O)-c1cccs1
Show InChI InChI=1S/C27H17N3O5S/c31-26-22-16-19(24-5-2-14-36-24)9-12-23(22)28-25(13-6-17-3-1-4-21(15-17)30(34)35)29(26)20-10-7-18(8-11-20)27(32)33/h1-16H,(H,32,33)/b13-6+
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

Similars
Article
PubMed
n/an/a 5.00E+3n/an/an/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Antagonist activity at rat recombinant NR1-NR2C receptor expressed in Xenopus oocytes at holding potential of -40mV by two-electrode voltage-clamp el...

J Med Chem 53: 5476-90 (2010)


Article DOI: 10.1021/jm100027p
BindingDB Entry DOI: 10.7270/Q2DR2VQF
More data for this
Ligand-Target Pair
Glutamate receptor 1


(Rattus norvegicus (Rat))		BDBM50324463
PNG
((E)-3-(2-(2-nitrostyryl)-4-oxoquinazolin-3(4H)-yl)...)
Show SMILES OC(=O)c1cccc(c1)-n1c(\C=C\c2ccccc2[N+]([O-])=O)nc2ccccc2c1=O
Show InChI InChI=1S/C23H15N3O5/c27-22-18-9-2-3-10-19(18)24-21(13-12-15-6-1-4-11-20(15)26(30)31)25(22)17-8-5-7-16(14-17)23(28)29/h1-14H,(H,28,29)/b13-12+
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 5.00E+3n/an/an/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Antagonist activity at rat recombinant GLuR1 expressed in Xenopus oocytes assessed as inhibition of glutamate-induced current by two-electrode voltag...

J Med Chem 53: 5476-90 (2010)


Article DOI: 10.1021/jm100027p
BindingDB Entry DOI: 10.7270/Q2DR2VQF
More data for this
Ligand-Target Pair
Glutamate receptor 1


(Rattus norvegicus (Rat))		BDBM50324404
PNG
((E)-4-(2-(3-Nitrostyryl)-4-oxo-6-phenylquinazolin-...)
Show SMILES OC(=O)c1ccc(cc1)-n1c(\C=C\c2cccc(c2)[N+]([O-])=O)nc2ccc(cc2c1=O)-c1ccccc1
Show InChI InChI=1S/C29H19N3O5/c33-28-25-18-22(20-6-2-1-3-7-20)12-15-26(25)30-27(16-9-19-5-4-8-24(17-19)32(36)37)31(28)23-13-10-21(11-14-23)29(34)35/h1-18H,(H,34,35)/b16-9+
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

Similars
Article
PubMed
n/an/a 5.00E+3n/an/an/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Antagonist activity at rat recombinant GLuR1 expressed in Xenopus oocytes assessed as inhibition of glutamate-induced current by two-electrode voltag...

J Med Chem 53: 5476-90 (2010)


Article DOI: 10.1021/jm100027p
BindingDB Entry DOI: 10.7270/Q2DR2VQF
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1/2B


(Rattus norvegicus (Rat)-RAT)		BDBM50324405
PNG
((E)-4-(2-(3-Nitrostyryl)-4-oxobenzo[g]quinazolin-3...)
Show SMILES OC(=O)c1ccc(cc1)-n1c(\C=C\c2cccc(c2)[N+]([O-])=O)nc2cc3ccccc3cc2c1=O
Show InChI InChI=1S/C27H17N3O5/c31-26-23-15-19-5-1-2-6-20(19)16-24(23)28-25(13-8-17-4-3-7-22(14-17)30(34)35)29(26)21-11-9-18(10-12-21)27(32)33/h1-16H,(H,32,33)/b13-8+
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

Similars
Article
PubMed
n/an/a 5.00E+3n/an/an/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Antagonist activity at rat recombinant NR1-NR2B receptor expressed in Xenopus oocytes at holding potential of -40mV by two-electrode voltage-clamp el...

J Med Chem 53: 5476-90 (2010)


Article DOI: 10.1021/jm100027p
BindingDB Entry DOI: 10.7270/Q2DR2VQF
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1/2C


(RAT-Rattus norvegicus (Rat))		BDBM50324400
PNG
((E)-4-(6-Methyl-2-(3-nitrostyryl)-4-oxoquinazolin-...)
Show SMILES Cc1ccc2nc(\C=C\c3cccc(c3)[N+]([O-])=O)n(-c3ccc(cc3)C(O)=O)c(=O)c2c1
Show InChI InChI=1S/C24H17N3O5/c1-15-5-11-21-20(13-15)23(28)26(18-9-7-17(8-10-18)24(29)30)22(25-21)12-6-16-3-2-4-19(14-16)27(31)32/h2-14H,1H3,(H,29,30)/b12-6+
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 5.00E+3n/an/an/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Antagonist activity at rat recombinant NR1-NR2C receptor expressed in Xenopus oocytes at holding potential of -40mV by two-electrode voltage-clamp el...

J Med Chem 53: 5476-90 (2010)


Article DOI: 10.1021/jm100027p
BindingDB Entry DOI: 10.7270/Q2DR2VQF
More data for this
Ligand-Target Pair
Glutamate receptor 1


(Rattus norvegicus (Rat))		BDBM50324461
PNG
((E)-4-(2-(2-nitrostyryl)-4-oxoquinazolin-3(4H)-yl)...)
Show SMILES OC(=O)c1ccc(cc1)-n1c(\C=C\c2ccccc2[N+]([O-])=O)nc2ccccc2c1=O
Show InChI InChI=1S/C23H15N3O5/c27-22-18-6-2-3-7-19(18)24-21(14-11-15-5-1-4-8-20(15)26(30)31)25(22)17-12-9-16(10-13-17)23(28)29/h1-14H,(H,28,29)/b14-11+
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 6.00E+3n/an/an/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Antagonist activity at rat recombinant GLuR1 expressed in Xenopus oocytes assessed as inhibition of glutamate-induced current by two-electrode voltag...

J Med Chem 53: 5476-90 (2010)


Article DOI: 10.1021/jm100027p
BindingDB Entry DOI: 10.7270/Q2DR2VQF
More data for this
Ligand-Target Pair
Displayed 1 to 50 (of 405 total )  |  Next  |  Last  >>
Jump to: