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Compile Data Set for Download or QSAR

Found 107 hits with Last Name = 'yamane' and Initial = 'h'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
RAC-alpha serine/threonine-protein kinase


(Homo sapiens (Human))
BDBM50312752
PNG
((S)-N1-(5-(isoquinolin-6-yl)-1,3,4-thiadiazol-2-yl...)
Show SMILES N[C@H](CNc1nnc(s1)-c1ccc2cnccc2c1)Cc1ccc(cc1)C(F)(F)F |r|
Show InChI InChI=1S/C21H18F3N5S/c22-21(23,24)17-5-1-13(2-6-17)9-18(25)12-27-20-29-28-19(30-20)15-3-4-16-11-26-8-7-14(16)10-15/h1-8,10-11,18H,9,12,25H2,(H,27,29)/t18-/m0/s1
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n/an/a 3n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of AKT1 after 10 mins by [gamma33]ATP assay


Bioorg Med Chem Lett 20: 1652-6 (2010)


Article DOI: 10.1016/j.bmcl.2010.01.046
BindingDB Entry DOI: 10.7270/Q21836MC
More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase


(Homo sapiens (Human))
BDBM50312752
PNG
((S)-N1-(5-(isoquinolin-6-yl)-1,3,4-thiadiazol-2-yl...)
Show SMILES N[C@H](CNc1nnc(s1)-c1ccc2cnccc2c1)Cc1ccc(cc1)C(F)(F)F |r|
Show InChI InChI=1S/C21H18F3N5S/c22-21(23,24)17-5-1-13(2-6-17)9-18(25)12-27-20-29-28-19(30-20)15-3-4-16-11-26-8-7-14(16)10-15/h1-8,10-11,18H,9,12,25H2,(H,27,29)/t18-/m0/s1
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n/an/a 3.20n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human AKT1 in human U87MG cells assessed as PRAS40 phosphorylation after 1 hr by ELISA


Bioorg Med Chem Lett 20: 1559-64 (2010)


Article DOI: 10.1016/j.bmcl.2010.01.067
BindingDB Entry DOI: 10.7270/Q20C4VWX
More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase


(Homo sapiens (Human))
BDBM50312922
PNG
((S)-N1-(5-(isoquinolin-6-yl)thiazol-2-yl)-3-(4-(tr...)
Show SMILES N[C@H](CNc1ncc(s1)-c1ccc2cnccc2c1)Cc1ccc(cc1)C(F)(F)F |r|
Show InChI InChI=1S/C22H19F3N4S/c23-22(24,25)18-5-1-14(2-6-18)9-19(26)12-28-21-29-13-20(30-21)16-3-4-17-11-27-8-7-15(17)10-16/h1-8,10-11,13,19H,9,12,26H2,(H,28,29)/t19-/m0/s1
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n/an/a 4.90n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human AKT1 in human U87MG cells assessed as PRAS40 phosphorylation after 1 hr by ELISA


Bioorg Med Chem Lett 20: 1559-64 (2010)


Article DOI: 10.1016/j.bmcl.2010.01.067
BindingDB Entry DOI: 10.7270/Q20C4VWX
More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase


(Homo sapiens (Human))
BDBM50312754
PNG
((S)-N1-(5-(3-methyl-1H-indazol-5-yl)-1,3,4-thiadia...)
Show SMILES Cc1n[nH]c2ccc(cc12)-c1nnc(NC[C@@H](N)Cc2ccc(cc2)C(F)(F)F)s1 |r|
Show InChI InChI=1S/C20H19F3N6S/c1-11-16-9-13(4-7-17(16)27-26-11)18-28-29-19(30-18)25-10-15(24)8-12-2-5-14(6-3-12)20(21,22)23/h2-7,9,15H,8,10,24H2,1H3,(H,25,29)(H,26,27)/t15-/m0/s1
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n/an/a 5.5n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of AKT1 after 10 mins by [gamma33]ATP assay


Bioorg Med Chem Lett 20: 1652-6 (2010)


Article DOI: 10.1016/j.bmcl.2010.01.046
BindingDB Entry DOI: 10.7270/Q21836MC
More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase


(Homo sapiens (Human))
BDBM50312750
PNG
((S)-N1-(5-(1H-indazol-5-yl)-1,3,4-thiadiazol-2-yl)...)
Show SMILES N[C@H](CNc1nnc(s1)-c1ccc2[nH]ncc2c1)Cc1ccc(cc1)C(F)(F)F |r|
Show InChI InChI=1S/C19H17F3N6S/c20-19(21,22)14-4-1-11(2-5-14)7-15(23)10-24-18-28-27-17(29-18)12-3-6-16-13(8-12)9-25-26-16/h1-6,8-9,15H,7,10,23H2,(H,24,28)(H,25,26)/t15-/m0/s1
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n/an/a 6n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of AKT1 after 10 mins by [gamma33]ATP assay


Bioorg Med Chem Lett 20: 1652-6 (2010)


Article DOI: 10.1016/j.bmcl.2010.01.046
BindingDB Entry DOI: 10.7270/Q21836MC
More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase


(Homo sapiens (Human))
BDBM50312744
PNG
((S)-N1-(5-(3-methyl-1H-indazol-5-yl)-1,3,4-thiadia...)
Show SMILES Cc1n[nH]c2ccc(cc12)-c1nnc(NC[C@@H](N)Cc2cccc(c2)C(F)(F)F)s1 |r|
Show InChI InChI=1S/C20H19F3N6S/c1-11-16-9-13(5-6-17(16)27-26-11)18-28-29-19(30-18)25-10-15(24)8-12-3-2-4-14(7-12)20(21,22)23/h2-7,9,15H,8,10,24H2,1H3,(H,25,29)(H,26,27)/t15-/m0/s1
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n/an/a 6.10n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of AKT1 after 10 mins by [gamma33]ATP assay


Bioorg Med Chem Lett 20: 1652-6 (2010)


Article DOI: 10.1016/j.bmcl.2010.01.046
BindingDB Entry DOI: 10.7270/Q21836MC
More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase


(Homo sapiens (Human))
BDBM50312934
PNG
((S)-6-(2-(2-amino-3-(4-(trifluoromethyl)phenyl)pro...)
Show SMILES N[C@H](CNc1ncc(s1)-c1ccc2[nH]c(=O)oc2c1)Cc1ccc(cc1)C(F)(F)F |r|
Show InChI InChI=1S/C20H17F3N4O2S/c21-20(22,23)13-4-1-11(2-5-13)7-14(24)9-25-18-26-10-17(30-18)12-3-6-15-16(8-12)29-19(28)27-15/h1-6,8,10,14H,7,9,24H2,(H,25,26)(H,27,28)/t14-/m0/s1
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n/an/a 8n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human AKT1 in human U87MG cells assessed as PRAS40 phosphorylation after 1 hr by ELISA


Bioorg Med Chem Lett 20: 1559-64 (2010)


Article DOI: 10.1016/j.bmcl.2010.01.067
BindingDB Entry DOI: 10.7270/Q20C4VWX
More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase


(Homo sapiens (Human))
BDBM50312931
PNG
((S)-N1-(5-(1H-indazol-5-yl)thiazol-2-yl)-3-(4-(tri...)
Show SMILES N[C@H](CNc1ncc(s1)-c1ccc2[nH]ncc2c1)Cc1ccc(cc1)C(F)(F)F |r|
Show InChI InChI=1S/C20H18F3N5S/c21-20(22,23)15-4-1-12(2-5-15)7-16(24)10-25-19-26-11-18(29-19)13-3-6-17-14(8-13)9-27-28-17/h1-6,8-9,11,16H,7,10,24H2,(H,25,26)(H,27,28)/t16-/m0/s1
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n/an/a 8.5n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human AKT1 in human U87MG cells assessed as PRAS40 phosphorylation after 1 hr by ELISA


Bioorg Med Chem Lett 20: 1559-64 (2010)


Article DOI: 10.1016/j.bmcl.2010.01.067
BindingDB Entry DOI: 10.7270/Q20C4VWX
More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase


(Homo sapiens (Human))
BDBM50312755
PNG
((S)-3-(4-chlorophenyl)-N1-(5-(3-methyl-1H-indazol-...)
Show SMILES Cc1n[nH]c2ccc(cc12)-c1nnc(NC[C@@H](N)Cc2ccc(Cl)cc2)s1 |r|
Show InChI InChI=1S/C19H19ClN6S/c1-11-16-9-13(4-7-17(16)24-23-11)18-25-26-19(27-18)22-10-15(21)8-12-2-5-14(20)6-3-12/h2-7,9,15H,8,10,21H2,1H3,(H,22,26)(H,23,24)/t15-/m0/s1
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n/an/a 8.90n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of AKT1 after 10 mins by [gamma33]ATP assay


Bioorg Med Chem Lett 20: 1652-6 (2010)


Article DOI: 10.1016/j.bmcl.2010.01.046
BindingDB Entry DOI: 10.7270/Q21836MC
More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase


(Homo sapiens (Human))
BDBM50312942
PNG
((S)-N1-(5-(3-aminoisoquinolin-6-yl)thiazol-2-yl)-3...)
Show SMILES N[C@H](CNc1ncc(s1)-c1ccc2cnc(N)cc2c1)Cc1ccc(cc1)C(F)(F)F |r|
Show InChI InChI=1S/C22H20F3N5S/c23-22(24,25)17-5-1-13(2-6-17)7-18(26)11-29-21-30-12-19(31-21)14-3-4-15-10-28-20(27)9-16(15)8-14/h1-6,8-10,12,18H,7,11,26H2,(H2,27,28)(H,29,30)/t18-/m0/s1
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n/an/a 12n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of AKT1 after 10 mins by [gamma33]ATP assay


Bioorg Med Chem Lett 20: 1559-64 (2010)


Article DOI: 10.1016/j.bmcl.2010.01.067
BindingDB Entry DOI: 10.7270/Q20C4VWX
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 2


(Homo sapiens (Human))
BDBM50312922
PNG
((S)-N1-(5-(isoquinolin-6-yl)thiazol-2-yl)-3-(4-(tr...)
Show SMILES N[C@H](CNc1ncc(s1)-c1ccc2cnccc2c1)Cc1ccc(cc1)C(F)(F)F |r|
Show InChI InChI=1S/C22H19F3N4S/c23-22(24,25)18-5-1-14(2-6-18)9-19(26)12-28-21-29-13-20(30-21)16-3-4-17-11-27-8-7-15(17)10-16/h1-8,10-11,13,19H,9,12,26H2,(H,28,29)/t19-/m0/s1
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n/an/a 12n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of CDK2


Bioorg Med Chem Lett 20: 1559-64 (2010)


Article DOI: 10.1016/j.bmcl.2010.01.067
BindingDB Entry DOI: 10.7270/Q20C4VWX
More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase


(Homo sapiens (Human))
BDBM50312757
PNG
((S)-3-(3,4-difluorophenyl)-N1-(5-(3-methyl-1H-inda...)
Show SMILES Cc1n[nH]c2ccc(cc12)-c1nnc(NC[C@@H](N)Cc2ccc(F)c(F)c2)s1 |r|
Show InChI InChI=1S/C19H18F2N6S/c1-10-14-8-12(3-5-17(14)25-24-10)18-26-27-19(28-18)23-9-13(22)6-11-2-4-15(20)16(21)7-11/h2-5,7-8,13H,6,9,22H2,1H3,(H,23,27)(H,24,25)/t13-/m0/s1
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n/an/a 14n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of AKT1 after 10 mins by [gamma33]ATP assay


Bioorg Med Chem Lett 20: 1652-6 (2010)


Article DOI: 10.1016/j.bmcl.2010.01.046
BindingDB Entry DOI: 10.7270/Q21836MC
More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase


(Homo sapiens (Human))
BDBM50312936
PNG
((S)-6-(2-(2-amino-3-(4-(trifluoromethyl)phenyl)pro...)
Show SMILES Cn1c2cc(ccc2[nH]c1=O)-c1cnc(NC[C@@H](N)Cc2ccc(cc2)C(F)(F)F)s1 |r|
Show InChI InChI=1S/C21H20F3N5OS/c1-29-17-9-13(4-7-16(17)28-20(29)30)18-11-27-19(31-18)26-10-15(25)8-12-2-5-14(6-3-12)21(22,23)24/h2-7,9,11,15H,8,10,25H2,1H3,(H,26,27)(H,28,30)/t15-/m0/s1
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n/an/a 15n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human AKT1 in human U87MG cells assessed as PRAS40 phosphorylation after 1 hr by ELISA


Bioorg Med Chem Lett 20: 1559-64 (2010)


Article DOI: 10.1016/j.bmcl.2010.01.067
BindingDB Entry DOI: 10.7270/Q20C4VWX
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 2


(Homo sapiens (Human))
BDBM50312942
PNG
((S)-N1-(5-(3-aminoisoquinolin-6-yl)thiazol-2-yl)-3...)
Show SMILES N[C@H](CNc1ncc(s1)-c1ccc2cnc(N)cc2c1)Cc1ccc(cc1)C(F)(F)F |r|
Show InChI InChI=1S/C22H20F3N5S/c23-22(24,25)17-5-1-13(2-6-17)7-18(26)11-29-21-30-12-19(31-21)14-3-4-15-10-28-20(27)9-16(15)8-14/h1-6,8-10,12,18H,7,11,26H2,(H2,27,28)(H,29,30)/t18-/m0/s1
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n/an/a 15n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of CDK2


Bioorg Med Chem Lett 20: 1559-64 (2010)


Article DOI: 10.1016/j.bmcl.2010.01.067
BindingDB Entry DOI: 10.7270/Q20C4VWX
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 2


(Homo sapiens (Human))
BDBM50312754
PNG
((S)-N1-(5-(3-methyl-1H-indazol-5-yl)-1,3,4-thiadia...)
Show SMILES Cc1n[nH]c2ccc(cc12)-c1nnc(NC[C@@H](N)Cc2ccc(cc2)C(F)(F)F)s1 |r|
Show InChI InChI=1S/C20H19F3N6S/c1-11-16-9-13(4-7-17(16)27-26-11)18-28-29-19(30-18)25-10-15(24)8-12-2-5-14(6-3-12)20(21,22)23/h2-7,9,15H,8,10,24H2,1H3,(H,25,29)(H,26,27)/t15-/m0/s1
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n/an/a 17n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of CDK2


Bioorg Med Chem Lett 20: 1652-6 (2010)


Article DOI: 10.1016/j.bmcl.2010.01.046
BindingDB Entry DOI: 10.7270/Q21836MC
More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase


(Homo sapiens (Human))
BDBM50312924
PNG
((S)-N1-(3-(isoquinolin-6-yl)isoxazol-5-yl)-3-(4-(t...)
Show SMILES N[C@H](CNc1cc(no1)-c1ccc2cnccc2c1)Cc1ccc(cc1)C(F)(F)F |r|
Show InChI InChI=1S/C22H19F3N4O/c23-22(24,25)18-5-1-14(2-6-18)9-19(26)13-28-21-11-20(29-30-21)16-3-4-17-12-27-8-7-15(17)10-16/h1-8,10-12,19,28H,9,13,26H2/t19-/m0/s1
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n/an/a 17n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human AKT1 in human U87MG cells assessed as PRAS40 phosphorylation after 1 hr by ELISA


Bioorg Med Chem Lett 20: 1559-64 (2010)


Article DOI: 10.1016/j.bmcl.2010.01.067
BindingDB Entry DOI: 10.7270/Q20C4VWX
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 2


(Homo sapiens (Human))
BDBM50312765
PNG
((S)-3-(3-chlorophenyl)-N1-(5-(3-methyl-1H-indazol-...)
Show SMILES Cc1n[nH]c2ccc(cc12)-c1nnc(NC[C@@H](N)Cc2cccc(Cl)c2)s1 |r|
Show InChI InChI=1S/C19H19ClN6S/c1-11-16-9-13(5-6-17(16)24-23-11)18-25-26-19(27-18)22-10-15(21)8-12-3-2-4-14(20)7-12/h2-7,9,15H,8,10,21H2,1H3,(H,22,26)(H,23,24)/t15-/m0/s1
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n/an/a 17n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of CDK2


Bioorg Med Chem Lett 20: 1652-6 (2010)


Article DOI: 10.1016/j.bmcl.2010.01.046
BindingDB Entry DOI: 10.7270/Q21836MC
More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase


(Homo sapiens (Human))
BDBM50312756
PNG
((S)-3-(2,4-dichlorophenyl)-N1-(5-(3-methyl-1H-inda...)
Show SMILES Cc1n[nH]c2ccc(cc12)-c1nnc(NC[C@@H](N)Cc2ccc(Cl)cc2Cl)s1 |r|
Show InChI InChI=1S/C19H18Cl2N6S/c1-10-15-7-12(3-5-17(15)25-24-10)18-26-27-19(28-18)23-9-14(22)6-11-2-4-13(20)8-16(11)21/h2-5,7-8,14H,6,9,22H2,1H3,(H,23,27)(H,24,25)/t14-/m0/s1
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n/an/a 18n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of AKT1 after 10 mins by [gamma33]ATP assay


Bioorg Med Chem Lett 20: 1652-6 (2010)


Article DOI: 10.1016/j.bmcl.2010.01.046
BindingDB Entry DOI: 10.7270/Q21836MC
More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase


(Homo sapiens (Human))
BDBM50312933
PNG
((S)-5-(2-(2-amino-3-(4-(trifluoromethyl)phenyl)pro...)
Show SMILES N[C@H](CNc1ncc(s1)-c1ccc2NC(=O)Cc2c1)Cc1ccc(cc1)C(F)(F)F |r|
Show InChI InChI=1S/C21H19F3N4OS/c22-21(23,24)15-4-1-12(2-5-15)7-16(25)10-26-20-27-11-18(30-20)13-3-6-17-14(8-13)9-19(29)28-17/h1-6,8,11,16H,7,9-10,25H2,(H,26,27)(H,28,29)/t16-/m0/s1
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n/an/a 18n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human AKT1 in human U87MG cells assessed as PRAS40 phosphorylation after 1 hr by ELISA


Bioorg Med Chem Lett 20: 1559-64 (2010)


Article DOI: 10.1016/j.bmcl.2010.01.067
BindingDB Entry DOI: 10.7270/Q20C4VWX
More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase


(Homo sapiens (Human))
BDBM50312765
PNG
((S)-3-(3-chlorophenyl)-N1-(5-(3-methyl-1H-indazol-...)
Show SMILES Cc1n[nH]c2ccc(cc12)-c1nnc(NC[C@@H](N)Cc2cccc(Cl)c2)s1 |r|
Show InChI InChI=1S/C19H19ClN6S/c1-11-16-9-13(5-6-17(16)24-23-11)18-25-26-19(27-18)22-10-15(21)8-12-3-2-4-14(20)7-12/h2-7,9,15H,8,10,21H2,1H3,(H,22,26)(H,23,24)/t15-/m0/s1
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n/an/a 19n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of AKT1 after 10 mins by [gamma33]ATP assay


Bioorg Med Chem Lett 20: 1652-6 (2010)


Article DOI: 10.1016/j.bmcl.2010.01.046
BindingDB Entry DOI: 10.7270/Q21836MC
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 2


(Homo sapiens (Human))
BDBM50312757
PNG
((S)-3-(3,4-difluorophenyl)-N1-(5-(3-methyl-1H-inda...)
Show SMILES Cc1n[nH]c2ccc(cc12)-c1nnc(NC[C@@H](N)Cc2ccc(F)c(F)c2)s1 |r|
Show InChI InChI=1S/C19H18F2N6S/c1-10-14-8-12(3-5-17(14)25-24-10)18-26-27-19(28-18)23-9-13(22)6-11-2-4-15(20)16(21)7-11/h2-5,7-8,13H,6,9,22H2,1H3,(H,23,27)(H,24,25)/t13-/m0/s1
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n/an/a 19n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of CDK2


Bioorg Med Chem Lett 20: 1652-6 (2010)


Article DOI: 10.1016/j.bmcl.2010.01.046
BindingDB Entry DOI: 10.7270/Q21836MC
More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase


(Homo sapiens (Human))
BDBM50312749
PNG
((S)-N1-(5-(1H-indazol-5-yl)-1,3,4-thiadiazol-2-yl)...)
Show SMILES N[C@H](CNc1nnc(s1)-c1ccc2[nH]ncc2c1)Cc1ccc(Cl)cc1 |r|
Show InChI InChI=1S/C18H17ClN6S/c19-14-4-1-11(2-5-14)7-15(20)10-21-18-25-24-17(26-18)12-3-6-16-13(8-12)9-22-23-16/h1-6,8-9,15H,7,10,20H2,(H,21,25)(H,22,23)/t15-/m0/s1
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n/an/a 24n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of AKT1 after 10 mins by [gamma33]ATP assay


Bioorg Med Chem Lett 20: 1652-6 (2010)


Article DOI: 10.1016/j.bmcl.2010.01.046
BindingDB Entry DOI: 10.7270/Q21836MC
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 2


(Homo sapiens (Human))
BDBM50312750
PNG
((S)-N1-(5-(1H-indazol-5-yl)-1,3,4-thiadiazol-2-yl)...)
Show SMILES N[C@H](CNc1nnc(s1)-c1ccc2[nH]ncc2c1)Cc1ccc(cc1)C(F)(F)F |r|
Show InChI InChI=1S/C19H17F3N6S/c20-19(21,22)14-4-1-11(2-5-14)7-15(23)10-24-18-28-27-17(29-18)12-3-6-16-13(8-12)9-25-26-16/h1-6,8-9,15H,7,10,23H2,(H,24,28)(H,25,26)/t15-/m0/s1
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n/an/a 24n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of CDK2


Bioorg Med Chem Lett 20: 1652-6 (2010)


Article DOI: 10.1016/j.bmcl.2010.01.046
BindingDB Entry DOI: 10.7270/Q21836MC
More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase


(Homo sapiens (Human))
BDBM50312747
PNG
((S)-N1-(5-(1H-indazol-5-yl)-1,3,4-thiadiazol-2-yl)...)
Show SMILES N[C@H](CNc1nnc(s1)-c1ccc2[nH]ncc2c1)Cc1cccc(c1)C(F)(F)F |r|
Show InChI InChI=1S/C19H17F3N6S/c20-19(21,22)14-3-1-2-11(6-14)7-15(23)10-24-18-28-27-17(29-18)12-4-5-16-13(8-12)9-25-26-16/h1-6,8-9,15H,7,10,23H2,(H,24,28)(H,25,26)/t15-/m0/s1
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n/an/a 25n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of AKT1 after 10 mins by [gamma33]ATP assay


Bioorg Med Chem Lett 20: 1652-6 (2010)


Article DOI: 10.1016/j.bmcl.2010.01.046
BindingDB Entry DOI: 10.7270/Q21836MC
More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase


(Homo sapiens (Human))
BDBM50312935
PNG
((S)-6-(2-(2-amino-3-(4-(trifluoromethyl)phenyl)pro...)
Show SMILES N[C@H](CNc1ncc(s1)-c1ccc2[nH]c(=O)sc2c1)Cc1ccc(cc1)C(F)(F)F |r|
Show InChI InChI=1S/C20H17F3N4OS2/c21-20(22,23)13-4-1-11(2-5-13)7-14(24)9-25-18-26-10-17(29-18)12-3-6-15-16(8-12)30-19(28)27-15/h1-6,8,10,14H,7,9,24H2,(H,25,26)(H,27,28)/t14-/m0/s1
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n/an/a 27n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human AKT1 in human U87MG cells assessed as PRAS40 phosphorylation after 1 hr by ELISA


Bioorg Med Chem Lett 20: 1559-64 (2010)


Article DOI: 10.1016/j.bmcl.2010.01.067
BindingDB Entry DOI: 10.7270/Q20C4VWX
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 2


(Homo sapiens (Human))
BDBM50312744
PNG
((S)-N1-(5-(3-methyl-1H-indazol-5-yl)-1,3,4-thiadia...)
Show SMILES Cc1n[nH]c2ccc(cc12)-c1nnc(NC[C@@H](N)Cc2cccc(c2)C(F)(F)F)s1 |r|
Show InChI InChI=1S/C20H19F3N6S/c1-11-16-9-13(5-6-17(16)27-26-11)18-28-29-19(30-18)25-10-15(24)8-12-3-2-4-14(7-12)20(21,22)23/h2-7,9,15H,8,10,24H2,1H3,(H,25,29)(H,26,27)/t15-/m0/s1
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n/an/a 35n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of CDK2


Bioorg Med Chem Lett 20: 1652-6 (2010)


Article DOI: 10.1016/j.bmcl.2010.01.046
BindingDB Entry DOI: 10.7270/Q21836MC
More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase


(Homo sapiens (Human))
BDBM50312943
PNG
((S)-N1-(5-(quinazolin-7-yl)thiazol-2-yl)-3-(4-(tri...)
Show SMILES N[C@H](CNc1ncc(s1)-c1ccc2cncnc2c1)Cc1ccc(cc1)C(F)(F)F |r|
Show InChI InChI=1S/C21H18F3N5S/c22-21(23,24)16-5-1-13(2-6-16)7-17(25)10-27-20-28-11-19(30-20)14-3-4-15-9-26-12-29-18(15)8-14/h1-6,8-9,11-12,17H,7,10,25H2,(H,27,28)/t17-/m0/s1
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n/an/a 35n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of AKT1 after 10 mins by [gamma33]ATP assay


Bioorg Med Chem Lett 20: 1559-64 (2010)


Article DOI: 10.1016/j.bmcl.2010.01.067
BindingDB Entry DOI: 10.7270/Q20C4VWX
More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase


(Homo sapiens (Human))
BDBM50312764
PNG
((S)-3-(3-fluorophenyl)-N1-(5-(3-methyl-1H-indazol-...)
Show SMILES Cc1n[nH]c2ccc(cc12)-c1nnc(NC[C@@H](N)Cc2cccc(F)c2)s1 |r|
Show InChI InChI=1S/C19H19FN6S/c1-11-16-9-13(5-6-17(16)24-23-11)18-25-26-19(27-18)22-10-15(21)8-12-3-2-4-14(20)7-12/h2-7,9,15H,8,10,21H2,1H3,(H,22,26)(H,23,24)/t15-/m0/s1
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n/an/a 38n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of AKT1 after 10 mins by [gamma33]ATP assay


Bioorg Med Chem Lett 20: 1652-6 (2010)


Article DOI: 10.1016/j.bmcl.2010.01.046
BindingDB Entry DOI: 10.7270/Q21836MC
More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase


(Homo sapiens (Human))
BDBM50312925
PNG
((R)-4-(3-(isoquinolin-6-yl)isoxazol-5-yl)-1-(4-(tr...)
Show SMILES N[C@H](CCc1cc(no1)-c1ccc2cnccc2c1)Cc1ccc(cc1)C(F)(F)F |r|
Show InChI InChI=1S/C23H20F3N3O/c24-23(25,26)19-5-1-15(2-6-19)11-20(27)7-8-21-13-22(29-30-21)17-3-4-18-14-28-10-9-16(18)12-17/h1-6,9-10,12-14,20H,7-8,11,27H2/t20-/m1/s1
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n/an/a 40n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human AKT1 in human U87MG cells assessed as PRAS40 phosphorylation after 1 hr by ELISA


Bioorg Med Chem Lett 20: 1559-64 (2010)


Article DOI: 10.1016/j.bmcl.2010.01.067
BindingDB Entry DOI: 10.7270/Q20C4VWX
More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase


(Homo sapiens (Human))
BDBM50312751
PNG
((S)-N1-(5-(1H-indazol-5-yl)-1,3,4-thiadiazol-2-yl)...)
Show SMILES N[C@H](CNc1nnc(s1)-c1ccc2[nH]ncc2c1)Cc1ccc(Cl)cc1Cl |r|
Show InChI InChI=1S/C18H16Cl2N6S/c19-13-3-1-10(15(20)7-13)6-14(21)9-22-18-26-25-17(27-18)11-2-4-16-12(5-11)8-23-24-16/h1-5,7-8,14H,6,9,21H2,(H,22,26)(H,23,24)/t14-/m0/s1
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n/an/a 40n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of AKT1 after 10 mins by [gamma33]ATP assay


Bioorg Med Chem Lett 20: 1652-6 (2010)


Article DOI: 10.1016/j.bmcl.2010.01.046
BindingDB Entry DOI: 10.7270/Q21836MC
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 2


(Homo sapiens (Human))
BDBM50312749
PNG
((S)-N1-(5-(1H-indazol-5-yl)-1,3,4-thiadiazol-2-yl)...)
Show SMILES N[C@H](CNc1nnc(s1)-c1ccc2[nH]ncc2c1)Cc1ccc(Cl)cc1 |r|
Show InChI InChI=1S/C18H17ClN6S/c19-14-4-1-11(2-5-14)7-15(20)10-21-18-25-24-17(26-18)12-3-6-16-13(8-12)9-22-23-16/h1-6,8-9,15H,7,10,20H2,(H,21,25)(H,22,23)/t15-/m0/s1
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n/an/a 41n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of CDK2


Bioorg Med Chem Lett 20: 1652-6 (2010)


Article DOI: 10.1016/j.bmcl.2010.01.046
BindingDB Entry DOI: 10.7270/Q21836MC
More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase


(Homo sapiens (Human))
BDBM50312762
PNG
((S)-3-(2-chlorophenyl)-N1-(5-(3-methyl-1H-indazol-...)
Show SMILES Cc1n[nH]c2ccc(cc12)-c1nnc(NC[C@@H](N)Cc2ccccc2Cl)s1 |r|
Show InChI InChI=1S/C19H19ClN6S/c1-11-15-9-13(6-7-17(15)24-23-11)18-25-26-19(27-18)22-10-14(21)8-12-4-2-3-5-16(12)20/h2-7,9,14H,8,10,21H2,1H3,(H,22,26)(H,23,24)/t14-/m0/s1
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n/an/a 47n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of AKT1 after 10 mins by [gamma33]ATP assay


Bioorg Med Chem Lett 20: 1652-6 (2010)


Article DOI: 10.1016/j.bmcl.2010.01.046
BindingDB Entry DOI: 10.7270/Q21836MC
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 2


(Homo sapiens (Human))
BDBM50312752
PNG
((S)-N1-(5-(isoquinolin-6-yl)-1,3,4-thiadiazol-2-yl...)
Show SMILES N[C@H](CNc1nnc(s1)-c1ccc2cnccc2c1)Cc1ccc(cc1)C(F)(F)F |r|
Show InChI InChI=1S/C21H18F3N5S/c22-21(23,24)17-5-1-13(2-6-17)9-18(25)12-27-20-29-28-19(30-20)15-3-4-16-11-26-8-7-14(16)10-15/h1-8,10-11,18H,9,12,25H2,(H,27,29)/t18-/m0/s1
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n/an/a 53n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of CDK2


Bioorg Med Chem Lett 20: 1559-64 (2010)


Article DOI: 10.1016/j.bmcl.2010.01.067
BindingDB Entry DOI: 10.7270/Q20C4VWX
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 2


(Homo sapiens (Human))
BDBM50312752
PNG
((S)-N1-(5-(isoquinolin-6-yl)-1,3,4-thiadiazol-2-yl...)
Show SMILES N[C@H](CNc1nnc(s1)-c1ccc2cnccc2c1)Cc1ccc(cc1)C(F)(F)F |r|
Show InChI InChI=1S/C21H18F3N5S/c22-21(23,24)17-5-1-13(2-6-17)9-18(25)12-27-20-29-28-19(30-20)15-3-4-16-11-26-8-7-14(16)10-15/h1-8,10-11,18H,9,12,25H2,(H,27,29)/t18-/m0/s1
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n/an/a 53n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of CDK2


Bioorg Med Chem Lett 20: 1652-6 (2010)


Article DOI: 10.1016/j.bmcl.2010.01.046
BindingDB Entry DOI: 10.7270/Q21836MC
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 2


(Homo sapiens (Human))
BDBM50312932
PNG
((S)-N1-(5-(1-amino-1H-benzo[d][1,2,3]triazol-6-yl)...)
Show SMILES N[C@H](CNc1ncc(s1)-c1ccc2nnn(N)c2c1)Cc1ccc(cc1)C(F)(F)F |r|
Show InChI InChI=1S/C19H18F3N7S/c20-19(21,22)13-4-1-11(2-5-13)7-14(23)9-25-18-26-10-17(30-18)12-3-6-15-16(8-12)29(24)28-27-15/h1-6,8,10,14H,7,9,23-24H2,(H,25,26)/t14-/m0/s1
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n/an/a 55n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of CDK2


Bioorg Med Chem Lett 20: 1559-64 (2010)


Article DOI: 10.1016/j.bmcl.2010.01.067
BindingDB Entry DOI: 10.7270/Q20C4VWX
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 2


(Homo sapiens (Human))
BDBM50312762
PNG
((S)-3-(2-chlorophenyl)-N1-(5-(3-methyl-1H-indazol-...)
Show SMILES Cc1n[nH]c2ccc(cc12)-c1nnc(NC[C@@H](N)Cc2ccccc2Cl)s1 |r|
Show InChI InChI=1S/C19H19ClN6S/c1-11-15-9-13(6-7-17(15)24-23-11)18-25-26-19(27-18)22-10-14(21)8-12-4-2-3-5-16(12)20/h2-7,9,14H,8,10,21H2,1H3,(H,22,26)(H,23,24)/t14-/m0/s1
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n/an/a 57n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of CDK2


Bioorg Med Chem Lett 20: 1652-6 (2010)


Article DOI: 10.1016/j.bmcl.2010.01.046
BindingDB Entry DOI: 10.7270/Q21836MC
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 2


(Homo sapiens (Human))
BDBM50312756
PNG
((S)-3-(2,4-dichlorophenyl)-N1-(5-(3-methyl-1H-inda...)
Show SMILES Cc1n[nH]c2ccc(cc12)-c1nnc(NC[C@@H](N)Cc2ccc(Cl)cc2Cl)s1 |r|
Show InChI InChI=1S/C19H18Cl2N6S/c1-10-15-7-12(3-5-17(15)25-24-10)18-26-27-19(28-18)23-9-14(22)6-11-2-4-13(20)8-16(11)21/h2-5,7-8,14H,6,9,22H2,1H3,(H,23,27)(H,24,25)/t14-/m0/s1
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n/an/a 70n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of CDK2


Bioorg Med Chem Lett 20: 1652-6 (2010)


Article DOI: 10.1016/j.bmcl.2010.01.046
BindingDB Entry DOI: 10.7270/Q21836MC
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 2


(Homo sapiens (Human))
BDBM50312759
PNG
((S)-N1-(5-(3-methyl-1H-indazol-5-yl)-1,3,4-thiadia...)
Show SMILES Cc1n[nH]c2ccc(cc12)-c1nnc(NC[C@@H](N)Cc2ccccc2)s1 |r|
Show InChI InChI=1S/C19H20N6S/c1-12-16-10-14(7-8-17(16)23-22-12)18-24-25-19(26-18)21-11-15(20)9-13-5-3-2-4-6-13/h2-8,10,15H,9,11,20H2,1H3,(H,21,25)(H,22,23)/t15-/m0/s1
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n/an/a 72n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of CDK2


Bioorg Med Chem Lett 20: 1652-6 (2010)


Article DOI: 10.1016/j.bmcl.2010.01.046
BindingDB Entry DOI: 10.7270/Q21836MC
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 2


(Homo sapiens (Human))
BDBM50312755
PNG
((S)-3-(4-chlorophenyl)-N1-(5-(3-methyl-1H-indazol-...)
Show SMILES Cc1n[nH]c2ccc(cc12)-c1nnc(NC[C@@H](N)Cc2ccc(Cl)cc2)s1 |r|
Show InChI InChI=1S/C19H19ClN6S/c1-11-16-9-13(4-7-17(16)24-23-11)18-25-26-19(27-18)22-10-15(21)8-12-2-5-14(20)6-3-12/h2-7,9,15H,8,10,21H2,1H3,(H,22,26)(H,23,24)/t15-/m0/s1
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n/an/a 72n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of CDK2


Bioorg Med Chem Lett 20: 1652-6 (2010)


Article DOI: 10.1016/j.bmcl.2010.01.046
BindingDB Entry DOI: 10.7270/Q21836MC
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 2


(Homo sapiens (Human))
BDBM50312748
PNG
((S)-N1-(5-(1H-indazol-5-yl)-1,3,4-thiadiazol-2-yl)...)
Show SMILES N[C@H](CNc1nnc(s1)-c1ccc2[nH]ncc2c1)Cc1ccc(F)cc1 |r|
Show InChI InChI=1S/C18H17FN6S/c19-14-4-1-11(2-5-14)7-15(20)10-21-18-25-24-17(26-18)12-3-6-16-13(8-12)9-22-23-16/h1-6,8-9,15H,7,10,20H2,(H,21,25)(H,22,23)/t15-/m0/s1
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n/an/a 74n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of CDK2


Bioorg Med Chem Lett 20: 1652-6 (2010)


Article DOI: 10.1016/j.bmcl.2010.01.046
BindingDB Entry DOI: 10.7270/Q21836MC
More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase


(Homo sapiens (Human))
BDBM50312759
PNG
((S)-N1-(5-(3-methyl-1H-indazol-5-yl)-1,3,4-thiadia...)
Show SMILES Cc1n[nH]c2ccc(cc12)-c1nnc(NC[C@@H](N)Cc2ccccc2)s1 |r|
Show InChI InChI=1S/C19H20N6S/c1-12-16-10-14(7-8-17(16)23-22-12)18-24-25-19(26-18)21-11-15(20)9-13-5-3-2-4-6-13/h2-8,10,15H,9,11,20H2,1H3,(H,21,25)(H,22,23)/t15-/m0/s1
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n/an/a 76n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of AKT1 after 10 mins by [gamma33]ATP assay


Bioorg Med Chem Lett 20: 1652-6 (2010)


Article DOI: 10.1016/j.bmcl.2010.01.046
BindingDB Entry DOI: 10.7270/Q21836MC
More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase


(Homo sapiens (Human))
BDBM50312932
PNG
((S)-N1-(5-(1-amino-1H-benzo[d][1,2,3]triazol-6-yl)...)
Show SMILES N[C@H](CNc1ncc(s1)-c1ccc2nnn(N)c2c1)Cc1ccc(cc1)C(F)(F)F |r|
Show InChI InChI=1S/C19H18F3N7S/c20-19(21,22)13-4-1-11(2-5-13)7-14(23)9-25-18-26-10-17(30-18)12-3-6-15-16(8-12)29(24)28-27-15/h1-6,8,10,14H,7,9,23-24H2,(H,25,26)/t14-/m0/s1
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n/an/a 77n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human AKT1 in human U87MG cells assessed as PRAS40 phosphorylation after 1 hr by ELISA


Bioorg Med Chem Lett 20: 1559-64 (2010)


Article DOI: 10.1016/j.bmcl.2010.01.067
BindingDB Entry DOI: 10.7270/Q20C4VWX
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 2


(Homo sapiens (Human))
BDBM50312746
PNG
((S)-N1-(5-(3-phenyl-1H-indazol-5-yl)-1,3,4-thiadia...)
Show SMILES N[C@H](CNc1nnc(s1)-c1ccc2[nH]nc(-c3ccccc3)c2c1)Cc1cccc(c1)C(F)(F)F |r|
Show InChI InChI=1S/C25H21F3N6S/c26-25(27,28)18-8-4-5-15(11-18)12-19(29)14-30-24-34-33-23(35-24)17-9-10-21-20(13-17)22(32-31-21)16-6-2-1-3-7-16/h1-11,13,19H,12,14,29H2,(H,30,34)(H,31,32)/t19-/m0/s1
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n/an/a 79n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of CDK2


Bioorg Med Chem Lett 20: 1652-6 (2010)


Article DOI: 10.1016/j.bmcl.2010.01.046
BindingDB Entry DOI: 10.7270/Q21836MC
More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase


(Homo sapiens (Human))
BDBM50312941
PNG
((S)-N1-(5-(isoquinolin-6-yl)-1,3,4-oxadiazol-2-yl)...)
Show SMILES N[C@H](CNc1nnc(o1)-c1ccc2cnccc2c1)Cc1ccc(cc1)C(F)(F)F |r|
Show InChI InChI=1S/C21H18F3N5O/c22-21(23,24)17-5-1-13(2-6-17)9-18(25)12-27-20-29-28-19(30-20)15-3-4-16-11-26-8-7-14(16)10-15/h1-8,10-11,18H,9,12,25H2,(H,27,29)/t18-/m0/s1
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n/an/a 85n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human AKT1 in human U87MG cells assessed as PRAS40 phosphorylation after 1 hr by ELISA


Bioorg Med Chem Lett 20: 1559-64 (2010)


Article DOI: 10.1016/j.bmcl.2010.01.067
BindingDB Entry DOI: 10.7270/Q20C4VWX
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 2


(Homo sapiens (Human))
BDBM50312924
PNG
((S)-N1-(3-(isoquinolin-6-yl)isoxazol-5-yl)-3-(4-(t...)
Show SMILES N[C@H](CNc1cc(no1)-c1ccc2cnccc2c1)Cc1ccc(cc1)C(F)(F)F |r|
Show InChI InChI=1S/C22H19F3N4O/c23-22(24,25)18-5-1-14(2-6-18)9-19(26)13-28-21-11-20(29-30-21)16-3-4-17-12-27-8-7-15(17)10-16/h1-8,10-12,19,28H,9,13,26H2/t19-/m0/s1
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n/an/a 93n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of CDK2


Bioorg Med Chem Lett 20: 1559-64 (2010)


Article DOI: 10.1016/j.bmcl.2010.01.067
BindingDB Entry DOI: 10.7270/Q20C4VWX
More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase


(Homo sapiens (Human))
BDBM50312940
PNG
((S)-5-(2-(2-amino-3-(4-(trifluoromethyl)phenyl)pro...)
Show SMILES N[C@H](CNc1ncc(s1)-c1ccc2C(=O)NCc2c1)Cc1ccc(cc1)C(F)(F)F |r|
Show InChI InChI=1S/C21H19F3N4OS/c22-21(23,24)15-4-1-12(2-5-15)7-16(25)10-27-20-28-11-18(30-20)13-3-6-17-14(8-13)9-26-19(17)29/h1-6,8,11,16H,7,9-10,25H2,(H,26,29)(H,27,28)/t16-/m0/s1
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n/an/a 95n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of AKT1 after 10 mins by [gamma33]ATP assay


Bioorg Med Chem Lett 20: 1559-64 (2010)


Article DOI: 10.1016/j.bmcl.2010.01.067
BindingDB Entry DOI: 10.7270/Q20C4VWX
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 2


(Homo sapiens (Human))
BDBM50312761
PNG
((S)-3-(2-fluorophenyl)-N1-(5-(3-methyl-1H-indazol-...)
Show SMILES Cc1n[nH]c2ccc(cc12)-c1nnc(NC[C@@H](N)Cc2ccccc2F)s1 |r|
Show InChI InChI=1S/C19H19FN6S/c1-11-15-9-13(6-7-17(15)24-23-11)18-25-26-19(27-18)22-10-14(21)8-12-4-2-3-5-16(12)20/h2-7,9,14H,8,10,21H2,1H3,(H,22,26)(H,23,24)/t14-/m0/s1
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n/an/a 104n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of CDK2


Bioorg Med Chem Lett 20: 1652-6 (2010)


Article DOI: 10.1016/j.bmcl.2010.01.046
BindingDB Entry DOI: 10.7270/Q21836MC
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM50312933
PNG
((S)-5-(2-(2-amino-3-(4-(trifluoromethyl)phenyl)pro...)
Show SMILES N[C@H](CNc1ncc(s1)-c1ccc2NC(=O)Cc2c1)Cc1ccc(cc1)C(F)(F)F |r|
Show InChI InChI=1S/C21H19F3N4OS/c22-21(23,24)15-4-1-12(2-5-15)7-16(25)10-26-20-27-11-18(30-20)13-3-6-17-14(8-13)9-19(29)28-17/h1-6,8,11,16H,7,9-10,25H2,(H,26,27)(H,28,29)/t16-/m0/s1
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n/an/a 110n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of cKIT


Bioorg Med Chem Lett 20: 1559-64 (2010)


Article DOI: 10.1016/j.bmcl.2010.01.067
BindingDB Entry DOI: 10.7270/Q20C4VWX
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 2


(Homo sapiens (Human))
BDBM50312925
PNG
((R)-4-(3-(isoquinolin-6-yl)isoxazol-5-yl)-1-(4-(tr...)
Show SMILES N[C@H](CCc1cc(no1)-c1ccc2cnccc2c1)Cc1ccc(cc1)C(F)(F)F |r|
Show InChI InChI=1S/C23H20F3N3O/c24-23(25,26)19-5-1-15(2-6-19)11-20(27)7-8-21-13-22(29-30-21)17-3-4-18-14-28-10-9-16(18)12-17/h1-6,9-10,12-14,20H,7-8,11,27H2/t20-/m1/s1
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n/an/a 117n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of CDK2


Bioorg Med Chem Lett 20: 1559-64 (2010)


Article DOI: 10.1016/j.bmcl.2010.01.067
BindingDB Entry DOI: 10.7270/Q20C4VWX
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 2


(Homo sapiens (Human))
BDBM50312745
PNG
((S)-N1-(5-(3-cyclopropyl-1H-indazol-5-yl)-1,3,4-th...)
Show SMILES N[C@H](CNc1nnc(s1)-c1ccc2[nH]nc(C3CC3)c2c1)Cc1ccc(cc1)C(F)(F)F |r|
Show InChI InChI=1S/C22H21F3N6S/c23-22(24,25)15-6-1-12(2-7-15)9-16(26)11-27-21-31-30-20(32-21)14-5-8-18-17(10-14)19(29-28-18)13-3-4-13/h1-2,5-8,10,13,16H,3-4,9,11,26H2,(H,27,31)(H,28,29)/t16-/m0/s1
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n/an/a 135n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of CDK2


Bioorg Med Chem Lett 20: 1652-6 (2010)


Article DOI: 10.1016/j.bmcl.2010.01.046
BindingDB Entry DOI: 10.7270/Q21836MC
More data for this
Ligand-Target Pair
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