Found 51 hits with Last Name = 'hirahara' and Initial = 'k' Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM14774
(3-(cyclopropylmethoxy)-N-(3,5-dichloropyridin-4-yl...)Show SMILES FC(F)Oc1ccc(cc1OCC1CC1)C(=O)Nc1c(Cl)cncc1Cl Show InChI InChI=1S/C17H14Cl2F2N2O3/c18-11-6-22-7-12(19)15(11)23-16(24)10-3-4-13(26-17(20)21)14(5-10)25-8-9-1-2-9/h3-7,9,17H,1-2,8H2,(H,22,23,24) | PDB
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| PDB
Article
PubMed
| n/a | n/a | 0.490 | n/a | n/a | n/a | n/a | n/a | n/a |
Kyushu University
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human PDE4B using cAMP as substrate after 30 mins |
Bioorg Med Chem 21: 7025-37 (2013)
Article DOI: 10.1016/j.bmc.2013.09.013
BindingDB Entry DOI: 10.7270/Q2DZ0C84 |
More data for this
Ligand-Target Pair | 
3D Structure (crystal) |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM14774
(3-(cyclopropylmethoxy)-N-(3,5-dichloropyridin-4-yl...)Show SMILES FC(F)Oc1ccc(cc1OCC1CC1)C(=O)Nc1c(Cl)cncc1Cl Show InChI InChI=1S/C17H14Cl2F2N2O3/c18-11-6-22-7-12(19)15(11)23-16(24)10-3-4-13(26-17(20)21)14(5-10)25-8-9-1-2-9/h3-7,9,17H,1-2,8H2,(H,22,23,24) | PDB
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MCE
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UniChem
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| PDB
Article
PubMed
| n/a | n/a | 0.490 | n/a | n/a | n/a | n/a | n/a | n/a |
Daiichi Sankyo Co., Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant PDE4B (152 to 564 amino acids) using cAMP as substrate after 30 mins by plate reader analysis |
Bioorg Med Chem Lett 23: 3325-8 (2013)
Article DOI: 10.1016/j.bmcl.2013.03.104
BindingDB Entry DOI: 10.7270/Q2QF8WSQ |
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50493949
(CHEMBL2442479)Show SMILES CC(=C)c1ncc(C(N)=O)c(Nc2ccc(CC(=O)NCC(C)(C)C)cc2)n1 Show InChI InChI=1S/C21H27N5O2/c1-13(2)19-23-11-16(18(22)28)20(26-19)25-15-8-6-14(7-9-15)10-17(27)24-12-21(3,4)5/h6-9,11H,1,10,12H2,2-5H3,(H2,22,28)(H,24,27)(H,23,25,26) | PDB
UniProtKB/SwissProt
antibodypedia
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| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 3.70 | n/a | n/a | n/a | n/a | n/a | n/a |
Kyushu University
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human PDE4B using cAMP as substrate after 30 mins |
Bioorg Med Chem 21: 7025-37 (2013)
Article DOI: 10.1016/j.bmc.2013.09.013
BindingDB Entry DOI: 10.7270/Q2DZ0C84 |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50491736
(CHEMBL2385759)Show SMILES CC(C)(C)CNC(=O)Cc1ccc(Nc2nc(nc3CCCS(=O)(=O)c23)-c2ccccc2)cc1 Show InChI InChI=1S/C26H30N4O3S/c1-26(2,3)17-27-22(31)16-18-11-13-20(14-12-18)28-25-23-21(10-7-15-34(23,32)33)29-24(30-25)19-8-5-4-6-9-19/h4-6,8-9,11-14H,7,10,15-17H2,1-3H3,(H,27,31)(H,28,29,30) | PDB
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| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 4.70 | n/a | n/a | n/a | n/a | n/a | n/a |
Daiichi Sankyo Co., Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant PDE4B (152 to 564 amino acids) using cAMP as substrate after 30 mins by plate reader analysis |
Bioorg Med Chem Lett 23: 3325-8 (2013)
Article DOI: 10.1016/j.bmcl.2013.03.104
BindingDB Entry DOI: 10.7270/Q2QF8WSQ |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50491737
(CHEMBL2385757)Show SMILES CC(C)CNC(=O)Cc1ccc(Nc2nc(nc3CCCS(=O)(=O)c23)-c2ccccc2)cc1 Show InChI InChI=1S/C25H28N4O3S/c1-17(2)16-26-22(30)15-18-10-12-20(13-11-18)27-25-23-21(9-6-14-33(23,31)32)28-24(29-25)19-7-4-3-5-8-19/h3-5,7-8,10-13,17H,6,9,14-16H2,1-2H3,(H,26,30)(H,27,28,29) | PDB
UniProtKB/SwissProt
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GoogleScholar
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| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 6.60 | n/a | n/a | n/a | n/a | n/a | n/a |
Daiichi Sankyo Co., Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant PDE4B (152 to 564 amino acids) using cAMP as substrate after 30 mins by plate reader analysis |
Bioorg Med Chem Lett 23: 3325-8 (2013)
Article DOI: 10.1016/j.bmcl.2013.03.104
BindingDB Entry DOI: 10.7270/Q2QF8WSQ |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50493958
(CHEMBL2442473)Show SMILES NC(=O)c1cnc(nc1Nc1ccc(CC(=O)NO)cc1)-c1ccccc1 Show InChI InChI=1S/C19H17N5O3/c20-17(26)15-11-21-18(13-4-2-1-3-5-13)23-19(15)22-14-8-6-12(7-9-14)10-16(25)24-27/h1-9,11,27H,10H2,(H2,20,26)(H,24,25)(H,21,22,23) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 7.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Kyushu University
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human PDE4B using cAMP as substrate after 30 mins |
Bioorg Med Chem 21: 7025-37 (2013)
Article DOI: 10.1016/j.bmc.2013.09.013
BindingDB Entry DOI: 10.7270/Q2DZ0C84 |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50493947
(CHEMBL2442465)Show SMILES CC(C)CNC(=O)Cc1ccc(Nc2nc(nc3CCNC(=O)c23)-c2ccccc2)cc1 Show InChI InChI=1S/C25H27N5O2/c1-16(2)15-27-21(31)14-17-8-10-19(11-9-17)28-24-22-20(12-13-26-25(22)32)29-23(30-24)18-6-4-3-5-7-18/h3-11,16H,12-15H2,1-2H3,(H,26,32)(H,27,31)(H,28,29,30) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 7.30 | n/a | n/a | n/a | n/a | n/a | n/a |
Kyushu University
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human PDE4B using cAMP as substrate after 30 mins |
Bioorg Med Chem 21: 7025-37 (2013)
Article DOI: 10.1016/j.bmc.2013.09.013
BindingDB Entry DOI: 10.7270/Q2DZ0C84 |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50491759
(CHEMBL2385755 | US11401286, Example 270)Show SMILES CCCNC(=O)Cc1ccc(Nc2nc(nc3CCCS(=O)(=O)c23)-c2ccccc2)cc1 Show InChI InChI=1S/C24H26N4O3S/c1-2-14-25-21(29)16-17-10-12-19(13-11-17)26-24-22-20(9-6-15-32(22,30)31)27-23(28-24)18-7-4-3-5-8-18/h3-5,7-8,10-13H,2,6,9,14-16H2,1H3,(H,25,29)(H,26,27,28) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 7.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Daiichi Sankyo Co., Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant PDE4B (152 to 564 amino acids) using cAMP as substrate after 30 mins by plate reader analysis |
Bioorg Med Chem Lett 23: 3325-8 (2013)
Article DOI: 10.1016/j.bmcl.2013.03.104
BindingDB Entry DOI: 10.7270/Q2QF8WSQ |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50493961
(CHEMBL2442478)Show SMILES CC(C)(C)CNC(=O)Cc1ccc(Nc2nc(ncc2C(N)=O)-c2ccc3[nH]ccc3c2)cc1 Show InChI InChI=1S/C26H28N6O2/c1-26(2,3)15-30-22(33)12-16-4-7-19(8-5-16)31-25-20(23(27)34)14-29-24(32-25)18-6-9-21-17(13-18)10-11-28-21/h4-11,13-14,28H,12,15H2,1-3H3,(H2,27,34)(H,30,33)(H,29,31,32) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 8.20 | n/a | n/a | n/a | n/a | n/a | n/a |
Kyushu University
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human PDE4B using cAMP as substrate after 30 mins |
Bioorg Med Chem 21: 7025-37 (2013)
Article DOI: 10.1016/j.bmc.2013.09.013
BindingDB Entry DOI: 10.7270/Q2DZ0C84 |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50493946
(CHEMBL2442472)Show SMILES CC(C)(C)CNC(=O)Cc1ccc(Nc2nc(ncc2C(N)=O)-c2ccccc2)cc1 Show InChI InChI=1S/C24H27N5O2/c1-24(2,3)15-27-20(30)13-16-9-11-18(12-10-16)28-23-19(21(25)31)14-26-22(29-23)17-7-5-4-6-8-17/h4-12,14H,13,15H2,1-3H3,(H2,25,31)(H,27,30)(H,26,28,29) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
PDB
UniChem
| PDB
Article
PubMed
| n/a | n/a | 8.30 | n/a | n/a | n/a | n/a | n/a | n/a |
Kyushu University
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human PDE4B using cAMP as substrate after 30 mins |
Bioorg Med Chem 21: 7025-37 (2013)
Article DOI: 10.1016/j.bmc.2013.09.013
BindingDB Entry DOI: 10.7270/Q2DZ0C84 |
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50493950
(CHEMBL2442477)Show SMILES CC(C)(C)CNC(=O)Cc1ccc(Nc2nc(ncc2C(N)=O)-c2ccoc2)cc1 Show InChI InChI=1S/C22H25N5O3/c1-22(2,3)13-25-18(28)10-14-4-6-16(7-5-14)26-21-17(19(23)29)11-24-20(27-21)15-8-9-30-12-15/h4-9,11-12H,10,13H2,1-3H3,(H2,23,29)(H,25,28)(H,24,26,27) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 11 | n/a | n/a | n/a | n/a | n/a | n/a |
Kyushu University
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human PDE4B using cAMP as substrate after 30 mins |
Bioorg Med Chem 21: 7025-37 (2013)
Article DOI: 10.1016/j.bmc.2013.09.013
BindingDB Entry DOI: 10.7270/Q2DZ0C84 |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50491753
(CHEMBL2385758)Show SMILES CC(C)(C)NC(=O)Cc1ccc(Nc2nc(nc3CCCS(=O)(=O)c23)-c2ccccc2)cc1 Show InChI InChI=1S/C25H28N4O3S/c1-25(2,3)29-21(30)16-17-11-13-19(14-12-17)26-24-22-20(10-7-15-33(22,31)32)27-23(28-24)18-8-5-4-6-9-18/h4-6,8-9,11-14H,7,10,15-16H2,1-3H3,(H,29,30)(H,26,27,28) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
PDB
UniChem
| PDB
Article
PubMed
| n/a | n/a | 11 | n/a | n/a | n/a | n/a | n/a | n/a |
Daiichi Sankyo Co., Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant PDE4B (152 to 564 amino acids) using cAMP as substrate after 30 mins by plate reader analysis |
Bioorg Med Chem Lett 23: 3325-8 (2013)
Article DOI: 10.1016/j.bmcl.2013.03.104
BindingDB Entry DOI: 10.7270/Q2QF8WSQ |
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50493962
(CHEMBL2442470)Show SMILES CC(C)CNC(=O)Cc1ccc(Nc2nc(ncc2C(N)=O)-c2ccccc2)cc1 Show InChI InChI=1S/C23H25N5O2/c1-15(2)13-25-20(29)12-16-8-10-18(11-9-16)27-23-19(21(24)30)14-26-22(28-23)17-6-4-3-5-7-17/h3-11,14-15H,12-13H2,1-2H3,(H2,24,30)(H,25,29)(H,26,27,28) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 11 | n/a | n/a | n/a | n/a | n/a | n/a |
Kyushu University
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human PDE4B using cAMP as substrate after 30 mins |
Bioorg Med Chem 21: 7025-37 (2013)
Article DOI: 10.1016/j.bmc.2013.09.013
BindingDB Entry DOI: 10.7270/Q2DZ0C84 |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50493948
(CHEMBL2442462)Show SMILES CC(C)(C)CNC(=O)Cc1ccc(Nc2nc(ncc2C(N)=O)N2CCCC2)cc1 Show InChI InChI=1S/C22H30N6O2/c1-22(2,3)14-25-18(29)12-15-6-8-16(9-7-15)26-20-17(19(23)30)13-24-21(27-20)28-10-4-5-11-28/h6-9,13H,4-5,10-12,14H2,1-3H3,(H2,23,30)(H,25,29)(H,24,26,27) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 13 | n/a | n/a | n/a | n/a | n/a | n/a |
Kyushu University
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human PDE4B using cAMP as substrate after 30 mins |
Bioorg Med Chem 21: 7025-37 (2013)
Article DOI: 10.1016/j.bmc.2013.09.013
BindingDB Entry DOI: 10.7270/Q2DZ0C84 |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50493953
(CHEMBL2442469)Show SMILES NC(=O)c1cnc(nc1Nc1ccc(CC(=O)NCC2CC2)cc1)-c1ccccc1 Show InChI InChI=1S/C23H23N5O2/c24-21(30)19-14-26-22(17-4-2-1-3-5-17)28-23(19)27-18-10-8-15(9-11-18)12-20(29)25-13-16-6-7-16/h1-5,8-11,14,16H,6-7,12-13H2,(H2,24,30)(H,25,29)(H,26,27,28) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 16 | n/a | n/a | n/a | n/a | n/a | n/a |
Kyushu University
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human PDE4B using cAMP as substrate after 30 mins |
Bioorg Med Chem 21: 7025-37 (2013)
Article DOI: 10.1016/j.bmc.2013.09.013
BindingDB Entry DOI: 10.7270/Q2DZ0C84 |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50493957
(CHEMBL2442461)Show SMILES CN(C)c1ncc(C(N)=O)c(Nc2ccc(CC(=O)NCC(C)(C)C)cc2)n1 Show InChI InChI=1S/C20H28N6O2/c1-20(2,3)12-23-16(27)10-13-6-8-14(9-7-13)24-18-15(17(21)28)11-22-19(25-18)26(4)5/h6-9,11H,10,12H2,1-5H3,(H2,21,28)(H,23,27)(H,22,24,25) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 16 | n/a | n/a | n/a | n/a | n/a | n/a |
Kyushu University
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human PDE4B using cAMP as substrate after 30 mins |
Bioorg Med Chem 21: 7025-37 (2013)
Article DOI: 10.1016/j.bmc.2013.09.013
BindingDB Entry DOI: 10.7270/Q2DZ0C84 |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50491738
(CHEMBL2385753 | US11401286, Example 269)Show SMILES NC(=O)Cc1ccc(Nc2nc(nc3CCCS(=O)(=O)c23)-c2ccccc2)cc1 Show InChI InChI=1S/C21H20N4O3S/c22-18(26)13-14-8-10-16(11-9-14)23-21-19-17(7-4-12-29(19,27)28)24-20(25-21)15-5-2-1-3-6-15/h1-3,5-6,8-11H,4,7,12-13H2,(H2,22,26)(H,23,24,25) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 16 | n/a | n/a | n/a | n/a | n/a | n/a |
Daiichi Sankyo Co., Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant PDE4B (152 to 564 amino acids) using cAMP as substrate after 30 mins by plate reader analysis |
Bioorg Med Chem Lett 23: 3325-8 (2013)
Article DOI: 10.1016/j.bmcl.2013.03.104
BindingDB Entry DOI: 10.7270/Q2QF8WSQ |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50491754
(CHEMBL2385756)Show SMILES CCCCNC(=O)Cc1ccc(Nc2nc(nc3CCCS(=O)(=O)c23)-c2ccccc2)cc1 Show InChI InChI=1S/C25H28N4O3S/c1-2-3-15-26-22(30)17-18-11-13-20(14-12-18)27-25-23-21(10-7-16-33(23,31)32)28-24(29-25)19-8-5-4-6-9-19/h4-6,8-9,11-14H,2-3,7,10,15-17H2,1H3,(H,26,30)(H,27,28,29) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 22 | n/a | n/a | n/a | n/a | n/a | n/a |
Daiichi Sankyo Co., Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant PDE4B (152 to 564 amino acids) using cAMP as substrate after 30 mins by plate reader analysis |
Bioorg Med Chem Lett 23: 3325-8 (2013)
Article DOI: 10.1016/j.bmcl.2013.03.104
BindingDB Entry DOI: 10.7270/Q2QF8WSQ |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50491740
(CHEMBL2385749)Show SMILES OC(=O)Cc1ccc(Nc2nc(nc3CCCS(=O)(=O)c23)-c2ccccc2)cc1 Show InChI InChI=1S/C21H19N3O4S/c25-18(26)13-14-8-10-16(11-9-14)22-21-19-17(7-4-12-29(19,27)28)23-20(24-21)15-5-2-1-3-6-15/h1-3,5-6,8-11H,4,7,12-13H2,(H,25,26)(H,22,23,24) | PDB
UniProtKB/SwissProt
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AffyNet
| KEGG
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 25 | n/a | n/a | n/a | n/a | n/a | n/a |
Daiichi Sankyo Co., Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant PDE4B (152 to 564 amino acids) using cAMP as substrate after 30 mins by plate reader analysis |
Bioorg Med Chem Lett 23: 3325-8 (2013)
Article DOI: 10.1016/j.bmcl.2013.03.104
BindingDB Entry DOI: 10.7270/Q2QF8WSQ |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50491751
(CHEMBL2385754)Show SMILES CNC(=O)Cc1ccc(Nc2nc(nc3CCCS(=O)(=O)c23)-c2ccccc2)cc1 Show InChI InChI=1S/C22H22N4O3S/c1-23-19(27)14-15-9-11-17(12-10-15)24-22-20-18(8-5-13-30(20,28)29)25-21(26-22)16-6-3-2-4-7-16/h2-4,6-7,9-12H,5,8,13-14H2,1H3,(H,23,27)(H,24,25,26) | PDB
UniProtKB/SwissProt
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GoogleScholar
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| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 27 | n/a | n/a | n/a | n/a | n/a | n/a |
Daiichi Sankyo Co., Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant PDE4B (152 to 564 amino acids) using cAMP as substrate after 30 mins by plate reader analysis |
Bioorg Med Chem Lett 23: 3325-8 (2013)
Article DOI: 10.1016/j.bmcl.2013.03.104
BindingDB Entry DOI: 10.7270/Q2QF8WSQ |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50491739
(CHEMBL2385750)Show SMILES OC(=O)Cc1ccc(Nc2nc(nc3CS(=O)(=O)CCc23)-c2ccccc2)cc1 Show InChI InChI=1S/C21H19N3O4S/c25-19(26)12-14-6-8-16(9-7-14)22-21-17-10-11-29(27,28)13-18(17)23-20(24-21)15-4-2-1-3-5-15/h1-9H,10-13H2,(H,25,26)(H,22,23,24) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
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| KEGG
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 28 | n/a | n/a | n/a | n/a | n/a | n/a |
Daiichi Sankyo Co., Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant PDE4B (152 to 564 amino acids) using cAMP as substrate after 30 mins by plate reader analysis |
Bioorg Med Chem Lett 23: 3325-8 (2013)
Article DOI: 10.1016/j.bmcl.2013.03.104
BindingDB Entry DOI: 10.7270/Q2QF8WSQ |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50491746
(CHEMBL2385559)Show InChI InChI=1S/C20H17N3O2S/c24-18(25)10-13-6-8-15(9-7-13)21-20-16-11-26-12-17(16)22-19(23-20)14-4-2-1-3-5-14/h1-9H,10-12H2,(H,24,25)(H,21,22,23) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| KEGG
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 29 | n/a | n/a | n/a | n/a | n/a | n/a |
Daiichi Sankyo Co., Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant PDE4B (152 to 564 amino acids) using cAMP as substrate after 30 mins by plate reader analysis |
Bioorg Med Chem Lett 23: 3325-8 (2013)
Article DOI: 10.1016/j.bmcl.2013.03.104
BindingDB Entry DOI: 10.7270/Q2QF8WSQ |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50493966
(CHEMBL2442475)Show SMILES CC(C)(C)CNC(=O)Cc1ccc(Nc2nc(ncc2C(N)=O)-c2cccnc2)cc1 Show InChI InChI=1S/C23H26N6O2/c1-23(2,3)14-27-19(30)11-15-6-8-17(9-7-15)28-22-18(20(24)31)13-26-21(29-22)16-5-4-10-25-12-16/h4-10,12-13H,11,14H2,1-3H3,(H2,24,31)(H,27,30)(H,26,28,29) | PDB
UniProtKB/SwissProt
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| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 29 | n/a | n/a | n/a | n/a | n/a | n/a |
Kyushu University
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human PDE4B using cAMP as substrate after 30 mins |
Bioorg Med Chem 21: 7025-37 (2013)
Article DOI: 10.1016/j.bmc.2013.09.013
BindingDB Entry DOI: 10.7270/Q2DZ0C84 |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50491761
(CHEMBL2385573)Show SMILES OC(=O)Cc1ccc(Nc2nc(nc3CCCSc23)-c2ccccc2)cc1 Show InChI InChI=1S/C21H19N3O2S/c25-18(26)13-14-8-10-16(11-9-14)22-21-19-17(7-4-12-27-19)23-20(24-21)15-5-2-1-3-6-15/h1-3,5-6,8-11H,4,7,12-13H2,(H,25,26)(H,22,23,24) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| KEGG
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 29 | n/a | n/a | n/a | n/a | n/a | n/a |
Daiichi Sankyo Co., Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant PDE4B (152 to 564 amino acids) using cAMP as substrate after 30 mins by plate reader analysis |
Bioorg Med Chem Lett 23: 3325-8 (2013)
Article DOI: 10.1016/j.bmcl.2013.03.104
BindingDB Entry DOI: 10.7270/Q2QF8WSQ |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50491735
(CHEMBL2385761)Show SMILES CN(C)C(=O)Cc1ccc(Nc2nc(nc3CCCS(=O)(=O)c23)-c2ccccc2)cc1 Show InChI InChI=1S/C23H24N4O3S/c1-27(2)20(28)15-16-10-12-18(13-11-16)24-23-21-19(9-6-14-31(21,29)30)25-22(26-23)17-7-4-3-5-8-17/h3-5,7-8,10-13H,6,9,14-15H2,1-2H3,(H,24,25,26) | PDB
UniProtKB/SwissProt
antibodypedia
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| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 33 | n/a | n/a | n/a | n/a | n/a | n/a |
Daiichi Sankyo Co., Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant PDE4B (152 to 564 amino acids) using cAMP as substrate after 30 mins by plate reader analysis |
Bioorg Med Chem Lett 23: 3325-8 (2013)
Article DOI: 10.1016/j.bmcl.2013.03.104
BindingDB Entry DOI: 10.7270/Q2QF8WSQ |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50491750
(CHEMBL2385760)Show SMILES O=C(Cc1ccc(Nc2nc(nc3CCCS(=O)(=O)c23)-c2ccccc2)cc1)Nc1ccccc1 Show InChI InChI=1S/C27H24N4O3S/c32-24(28-21-10-5-2-6-11-21)18-19-13-15-22(16-14-19)29-27-25-23(12-7-17-35(25,33)34)30-26(31-27)20-8-3-1-4-9-20/h1-6,8-11,13-16H,7,12,17-18H2,(H,28,32)(H,29,30,31) | PDB
UniProtKB/SwissProt
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| PC cid
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UniChem
| Article
PubMed
| n/a | n/a | 43 | n/a | n/a | n/a | n/a | n/a | n/a |
Daiichi Sankyo Co., Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant PDE4B (152 to 564 amino acids) using cAMP as substrate after 30 mins by plate reader analysis |
Bioorg Med Chem Lett 23: 3325-8 (2013)
Article DOI: 10.1016/j.bmcl.2013.03.104
BindingDB Entry DOI: 10.7270/Q2QF8WSQ |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50493959
(CHEMBL2442464)Show SMILES OC(=O)Cc1ccc(Nc2nc(nc3CCNC(=O)c23)-c2ccccc2)cc1 Show InChI InChI=1S/C21H18N4O3/c26-17(27)12-13-6-8-15(9-7-13)23-20-18-16(10-11-22-21(18)28)24-19(25-20)14-4-2-1-3-5-14/h1-9H,10-12H2,(H,22,28)(H,26,27)(H,23,24,25) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| KEGG
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 47 | n/a | n/a | n/a | n/a | n/a | n/a |
Kyushu University
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human PDE4B using cAMP as substrate after 30 mins |
Bioorg Med Chem 21: 7025-37 (2013)
Article DOI: 10.1016/j.bmc.2013.09.013
BindingDB Entry DOI: 10.7270/Q2DZ0C84 |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50493952
(CHEMBL2442471)Show SMILES CC(C)(C)NC(=O)Cc1ccc(Nc2nc(ncc2C(N)=O)-c2ccccc2)cc1 Show InChI InChI=1S/C23H25N5O2/c1-23(2,3)28-19(29)13-15-9-11-17(12-10-15)26-22-18(20(24)30)14-25-21(27-22)16-7-5-4-6-8-16/h4-12,14H,13H2,1-3H3,(H2,24,30)(H,28,29)(H,25,26,27) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 110 | n/a | n/a | n/a | n/a | n/a | n/a |
Kyushu University
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human PDE4B using cAMP as substrate after 30 mins |
Bioorg Med Chem 21: 7025-37 (2013)
Article DOI: 10.1016/j.bmc.2013.09.013
BindingDB Entry DOI: 10.7270/Q2DZ0C84 |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50493951
(CHEMBL2440142)Show SMILES CC(C)(C)CNC(=O)Cc1ccc(Nc2nc(ncc2C(N)=O)-c2cncnc2)cc1 Show InChI InChI=1S/C22H25N7O2/c1-22(2,3)12-27-18(30)8-14-4-6-16(7-5-14)28-21-17(19(23)31)11-26-20(29-21)15-9-24-13-25-10-15/h4-7,9-11,13H,8,12H2,1-3H3,(H2,23,31)(H,27,30)(H,26,28,29) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 110 | n/a | n/a | n/a | n/a | n/a | n/a |
Kyushu University
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human PDE4B using cAMP as substrate after 30 mins |
Bioorg Med Chem 21: 7025-37 (2013)
Article DOI: 10.1016/j.bmc.2013.09.013
BindingDB Entry DOI: 10.7270/Q2DZ0C84 |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50493955
(CHEMBL2442467)Show SMILES NC(=O)Cc1ccc(Nc2nc(ncc2C(N)=O)-c2ccccc2)cc1 Show InChI InChI=1S/C19H17N5O2/c20-16(25)10-12-6-8-14(9-7-12)23-19-15(17(21)26)11-22-18(24-19)13-4-2-1-3-5-13/h1-9,11H,10H2,(H2,20,25)(H2,21,26)(H,22,23,24) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 120 | n/a | n/a | n/a | n/a | n/a | n/a |
Kyushu University
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human PDE4B using cAMP as substrate after 30 mins |
Bioorg Med Chem 21: 7025-37 (2013)
Article DOI: 10.1016/j.bmc.2013.09.013
BindingDB Entry DOI: 10.7270/Q2DZ0C84 |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50493954
(CHEMBL2442468)Show SMILES CCCNC(=O)Cc1ccc(Nc2nc(ncc2C(N)=O)-c2ccccc2)cc1 Show InChI InChI=1S/C22H23N5O2/c1-2-12-24-19(28)13-15-8-10-17(11-9-15)26-22-18(20(23)29)14-25-21(27-22)16-6-4-3-5-7-16/h3-11,14H,2,12-13H2,1H3,(H2,23,29)(H,24,28)(H,25,26,27) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 120 | n/a | n/a | n/a | n/a | n/a | n/a |
Kyushu University
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human PDE4B using cAMP as substrate after 30 mins |
Bioorg Med Chem 21: 7025-37 (2013)
Article DOI: 10.1016/j.bmc.2013.09.013
BindingDB Entry DOI: 10.7270/Q2DZ0C84 |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50491744
(CHEMBL2385563)Show SMILES OC(=O)Cc1ccc(Nc2nc(nc3CS(=O)(=O)Cc23)-c2ccccc2)cc1 Show InChI InChI=1S/C20H17N3O4S/c24-18(25)10-13-6-8-15(9-7-13)21-20-16-11-28(26,27)12-17(16)22-19(23-20)14-4-2-1-3-5-14/h1-9H,10-12H2,(H,24,25)(H,21,22,23) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| KEGG
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 140 | n/a | n/a | n/a | n/a | n/a | n/a |
Daiichi Sankyo Co., Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant PDE4B (152 to 564 amino acids) using cAMP as substrate after 30 mins by plate reader analysis |
Bioorg Med Chem Lett 23: 3325-8 (2013)
Article DOI: 10.1016/j.bmcl.2013.03.104
BindingDB Entry DOI: 10.7270/Q2QF8WSQ |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50491747
(CHEMBL2385558)Show InChI InChI=1S/C19H21N3O2S/c23-17(24)10-13-6-8-22(9-7-13)19-15-11-25-12-16(15)20-18(21-19)14-4-2-1-3-5-14/h1-5,13H,6-12H2,(H,23,24) | PDB
UniProtKB/SwissProt
antibodypedia
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| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 150 | n/a | n/a | n/a | n/a | n/a | n/a |
Daiichi Sankyo Co., Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant PDE4B (152 to 564 amino acids) using cAMP as substrate after 30 mins by plate reader analysis |
Bioorg Med Chem Lett 23: 3325-8 (2013)
Article DOI: 10.1016/j.bmcl.2013.03.104
BindingDB Entry DOI: 10.7270/Q2QF8WSQ |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50491745
(CHEMBL2385560)Show SMILES OC(=O)CC1CCN(CC1)c1nc(nc2CS(=O)(=O)Cc12)-c1ccccc1 Show InChI InChI=1S/C19H21N3O4S/c23-17(24)10-13-6-8-22(9-7-13)19-15-11-27(25,26)12-16(15)20-18(21-19)14-4-2-1-3-5-14/h1-5,13H,6-12H2,(H,23,24) | PDB
UniProtKB/SwissProt
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| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 190 | n/a | n/a | n/a | n/a | n/a | n/a |
Daiichi Sankyo Co., Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant PDE4B (152 to 564 amino acids) using cAMP as substrate after 30 mins by plate reader analysis |
Bioorg Med Chem Lett 23: 3325-8 (2013)
Article DOI: 10.1016/j.bmcl.2013.03.104
BindingDB Entry DOI: 10.7270/Q2QF8WSQ |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50493967
(CHEMBL2442480)Show SMILES NC(=O)c1cnc(nc1Nc1ccc(CC(O)=O)cc1)-c1ccccc1 Show InChI InChI=1S/C19H16N4O3/c20-17(26)15-11-21-18(13-4-2-1-3-5-13)23-19(15)22-14-8-6-12(7-9-14)10-16(24)25/h1-9,11H,10H2,(H2,20,26)(H,24,25)(H,21,22,23) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| KEGG
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 200 | n/a | n/a | n/a | n/a | n/a | n/a |
Kyushu University
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human PDE4B using cAMP as substrate after 30 mins |
Bioorg Med Chem 21: 7025-37 (2013)
Article DOI: 10.1016/j.bmc.2013.09.013
BindingDB Entry DOI: 10.7270/Q2DZ0C84 |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50491741
(CHEMBL2385572)Show InChI InChI=1S/C20H15N3O2S/c24-17(25)12-13-6-8-15(9-7-13)21-19-16-10-11-26-20(16)23-18(22-19)14-4-2-1-3-5-14/h1-11H,12H2,(H,24,25)(H,21,22,23) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| KEGG
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 230 | n/a | n/a | n/a | n/a | n/a | n/a |
Daiichi Sankyo Co., Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant PDE4B (152 to 564 amino acids) using cAMP as substrate after 30 mins by plate reader analysis |
Bioorg Med Chem Lett 23: 3325-8 (2013)
Article DOI: 10.1016/j.bmcl.2013.03.104
BindingDB Entry DOI: 10.7270/Q2QF8WSQ |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50491752
(CHEMBL2385751)Show SMILES OC(=O)Cc1ccc(Nc2nc(nc3CCS(=O)(=O)c23)-c2ccccc2)cc1 Show InChI InChI=1S/C20H17N3O4S/c24-17(25)12-13-6-8-15(9-7-13)21-20-18-16(10-11-28(18,26)27)22-19(23-20)14-4-2-1-3-5-14/h1-9H,10-12H2,(H,24,25)(H,21,22,23) | PDB
UniProtKB/SwissProt
antibodypedia
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PC sid
UniChem
| Article
PubMed
| n/a | n/a | 280 | n/a | n/a | n/a | n/a | n/a | n/a |
Daiichi Sankyo Co., Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant PDE4B (152 to 564 amino acids) using cAMP as substrate after 30 mins by plate reader analysis |
Bioorg Med Chem Lett 23: 3325-8 (2013)
Article DOI: 10.1016/j.bmcl.2013.03.104
BindingDB Entry DOI: 10.7270/Q2QF8WSQ |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50491742
(CHEMBL2385567)Show SMILES OC(=O)Cc1ccc(Nc2nc(nc3CCCCc23)-c2ccccc2)cc1 Show InChI InChI=1S/C22H21N3O2/c26-20(27)14-15-10-12-17(13-11-15)23-22-18-8-4-5-9-19(18)24-21(25-22)16-6-2-1-3-7-16/h1-3,6-7,10-13H,4-5,8-9,14H2,(H,26,27)(H,23,24,25) | PDB
UniProtKB/SwissProt
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AffyNet
| Purchase
KEGG
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 430 | n/a | n/a | n/a | n/a | n/a | n/a |
Daiichi Sankyo Co., Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant PDE4B (152 to 564 amino acids) using cAMP as substrate after 30 mins by plate reader analysis |
Bioorg Med Chem Lett 23: 3325-8 (2013)
Article DOI: 10.1016/j.bmcl.2013.03.104
BindingDB Entry DOI: 10.7270/Q2QF8WSQ |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50491748
(CHEMBL2385570)Show SMILES OC(=O)Cc1ccc(Nc2nc(nc3ccccc23)-c2ccccc2)cc1 Show InChI InChI=1S/C22H17N3O2/c26-20(27)14-15-10-12-17(13-11-15)23-22-18-8-4-5-9-19(18)24-21(25-22)16-6-2-1-3-7-16/h1-13H,14H2,(H,26,27)(H,23,24,25) | PDB
UniProtKB/SwissProt
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PC sid
UniChem
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PubMed
| n/a | n/a | 480 | n/a | n/a | n/a | n/a | n/a | n/a |
Daiichi Sankyo Co., Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant PDE4B (152 to 564 amino acids) using cAMP as substrate after 30 mins by plate reader analysis |
Bioorg Med Chem Lett 23: 3325-8 (2013)
Article DOI: 10.1016/j.bmcl.2013.03.104
BindingDB Entry DOI: 10.7270/Q2QF8WSQ |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50493964
(CHEMBL2442474)Show SMILES CS(=O)(=O)NC(=O)Cc1ccc(Nc2nc(ncc2C(N)=O)-c2ccccc2)cc1 Show InChI InChI=1S/C20H19N5O4S/c1-30(28,29)25-17(26)11-13-7-9-15(10-8-13)23-20-16(18(21)27)12-22-19(24-20)14-5-3-2-4-6-14/h2-10,12H,11H2,1H3,(H2,21,27)(H,25,26)(H,22,23,24) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 490 | n/a | n/a | n/a | n/a | n/a | n/a |
Kyushu University
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human PDE4B using cAMP as substrate after 30 mins |
Bioorg Med Chem 21: 7025-37 (2013)
Article DOI: 10.1016/j.bmc.2013.09.013
BindingDB Entry DOI: 10.7270/Q2DZ0C84 |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50491756
(CHEMBL2385566)Show InChI InChI=1S/C21H19N3O2/c25-19(26)13-14-9-11-16(12-10-14)22-21-17-7-4-8-18(17)23-20(24-21)15-5-2-1-3-6-15/h1-3,5-6,9-12H,4,7-8,13H2,(H,25,26)(H,22,23,24) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| KEGG
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 610 | n/a | n/a | n/a | n/a | n/a | n/a |
Daiichi Sankyo Co., Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant PDE4B (152 to 564 amino acids) using cAMP as substrate after 30 mins by plate reader analysis |
Bioorg Med Chem Lett 23: 3325-8 (2013)
Article DOI: 10.1016/j.bmcl.2013.03.104
BindingDB Entry DOI: 10.7270/Q2QF8WSQ |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50491743
(CHEMBL2385565)Show SMILES OC(=O)CCc1ccc(Nc2nc(nc3CS(=O)(=O)Cc23)-c2ccccc2)cc1 Show InChI InChI=1S/C21H19N3O4S/c25-19(26)11-8-14-6-9-16(10-7-14)22-21-17-12-29(27,28)13-18(17)23-20(24-21)15-4-2-1-3-5-15/h1-7,9-10H,8,11-13H2,(H,25,26)(H,22,23,24) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 800 | n/a | n/a | n/a | n/a | n/a | n/a |
Daiichi Sankyo Co., Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant PDE4B (152 to 564 amino acids) using cAMP as substrate after 30 mins by plate reader analysis |
Bioorg Med Chem Lett 23: 3325-8 (2013)
Article DOI: 10.1016/j.bmcl.2013.03.104
BindingDB Entry DOI: 10.7270/Q2QF8WSQ |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50493963
(CHEMBL2442482)Show SMILES CSc1nc(nc(Nc2ccc(CC(O)=O)cc2)c1C(N)=O)-c1ccccc1 Show InChI InChI=1S/C20H18N4O3S/c1-28-20-16(17(21)27)19(23-18(24-20)13-5-3-2-4-6-13)22-14-9-7-12(8-10-14)11-15(25)26/h2-10H,11H2,1H3,(H2,21,27)(H,25,26)(H,22,23,24) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| KEGG
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 2.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Kyushu University
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human PDE4B using cAMP as substrate after 30 mins |
Bioorg Med Chem 21: 7025-37 (2013)
Article DOI: 10.1016/j.bmc.2013.09.013
BindingDB Entry DOI: 10.7270/Q2DZ0C84 |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50491760
(CHEMBL2385569)Show InChI InChI=1S/C20H17N3O3/c24-18(25)10-13-6-8-15(9-7-13)21-20-16-11-26-12-17(16)22-19(23-20)14-4-2-1-3-5-14/h1-9H,10-12H2,(H,24,25)(H,21,22,23) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| KEGG
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 2.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Daiichi Sankyo Co., Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant PDE4B (152 to 564 amino acids) using cAMP as substrate after 30 mins by plate reader analysis |
Bioorg Med Chem Lett 23: 3325-8 (2013)
Article DOI: 10.1016/j.bmcl.2013.03.104
BindingDB Entry DOI: 10.7270/Q2QF8WSQ |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50491758
(CHEMBL2385564)Show SMILES OC(=O)Cc1cccc(Nc2nc(nc3CS(=O)(=O)Cc23)-c2ccccc2)c1 Show InChI InChI=1S/C20H17N3O4S/c24-18(25)10-13-5-4-8-15(9-13)21-20-16-11-28(26,27)12-17(16)22-19(23-20)14-6-2-1-3-7-14/h1-9H,10-12H2,(H,24,25)(H,21,22,23) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 2.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Daiichi Sankyo Co., Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant PDE4B (152 to 564 amino acids) using cAMP as substrate after 30 mins by plate reader analysis |
Bioorg Med Chem Lett 23: 3325-8 (2013)
Article DOI: 10.1016/j.bmcl.2013.03.104
BindingDB Entry DOI: 10.7270/Q2QF8WSQ |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50491757
(CHEMBL2385562)Show SMILES OC(=O)CN1CCC(CC1)Nc1nc(nc2CS(=O)(=O)Cc12)-c1ccccc1 Show InChI InChI=1S/C19H22N4O4S/c24-17(25)10-23-8-6-14(7-9-23)20-19-15-11-28(26,27)12-16(15)21-18(22-19)13-4-2-1-3-5-13/h1-5,14H,6-12H2,(H,24,25)(H,20,21,22) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 3.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Daiichi Sankyo Co., Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant PDE4B (152 to 564 amino acids) using cAMP as substrate after 30 mins by plate reader analysis |
Bioorg Med Chem Lett 23: 3325-8 (2013)
Article DOI: 10.1016/j.bmcl.2013.03.104
BindingDB Entry DOI: 10.7270/Q2QF8WSQ |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50493956
(CHEMBL2442481)Show SMILES Cc1nc(nc(Nc2ccc(CC(O)=O)cc2)c1C(N)=O)-c1ccccc1 Show InChI InChI=1S/C20H18N4O3/c1-12-17(18(21)27)20(24-19(22-12)14-5-3-2-4-6-14)23-15-9-7-13(8-10-15)11-16(25)26/h2-10H,11H2,1H3,(H2,21,27)(H,25,26)(H,22,23,24) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| KEGG
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 4.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Kyushu University
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human PDE4B using cAMP as substrate after 30 mins |
Bioorg Med Chem 21: 7025-37 (2013)
Article DOI: 10.1016/j.bmc.2013.09.013
BindingDB Entry DOI: 10.7270/Q2DZ0C84 |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50491749
(CHEMBL2385561)Show SMILES OC(=O)CN1CCN(CC1)c1nc(nc2CS(=O)(=O)Cc12)-c1ccccc1 Show InChI InChI=1S/C18H20N4O4S/c23-16(24)10-21-6-8-22(9-7-21)18-14-11-27(25,26)12-15(14)19-17(20-18)13-4-2-1-3-5-13/h1-5H,6-12H2,(H,23,24) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 5.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Daiichi Sankyo Co., Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant PDE4B (152 to 564 amino acids) using cAMP as substrate after 30 mins by plate reader analysis |
Bioorg Med Chem Lett 23: 3325-8 (2013)
Article DOI: 10.1016/j.bmcl.2013.03.104
BindingDB Entry DOI: 10.7270/Q2QF8WSQ |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50493960
(CHEMBL2442463)Show SMILES CC(C)(C)CNC(=O)Cc1ccc(Nc2nc(NN3CCCCC3)ncc2C(N)=O)cc1 Show InChI InChI=1S/C23H33N7O2/c1-23(2,3)15-26-19(31)13-16-7-9-17(10-8-16)27-21-18(20(24)32)14-25-22(28-21)29-30-11-5-4-6-12-30/h7-10,14H,4-6,11-13,15H2,1-3H3,(H2,24,32)(H,26,31)(H2,25,27,28,29) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 6.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Kyushu University
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human PDE4B using cAMP as substrate after 30 mins |
Bioorg Med Chem 21: 7025-37 (2013)
Article DOI: 10.1016/j.bmc.2013.09.013
BindingDB Entry DOI: 10.7270/Q2DZ0C84 |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50491755
(CHEMBL2385752)Show SMILES OC(=O)Cc1ccc(Nc2nc(nc3CCS(=O)(=O)Cc23)-c2ccccc2)cc1 Show InChI InChI=1S/C21H19N3O4S/c25-19(26)12-14-6-8-16(9-7-14)22-21-17-13-29(27,28)11-10-18(17)23-20(24-21)15-4-2-1-3-5-15/h1-9H,10-13H2,(H,25,26)(H,22,23,24) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| KEGG
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 7.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Daiichi Sankyo Co., Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant PDE4B (152 to 564 amino acids) using cAMP as substrate after 30 mins by plate reader analysis |
Bioorg Med Chem Lett 23: 3325-8 (2013)
Article DOI: 10.1016/j.bmcl.2013.03.104
BindingDB Entry DOI: 10.7270/Q2QF8WSQ |
More data for this
Ligand-Target Pair | |
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