Found 34 hits with Last Name = 'hillegass' and Initial = 'lm' Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Phenylethanolamine N-methyltransferase
(Homo sapiens (Human)) | BDBM13014
![PNG](/data/jpeg/tenK1/BindingDB_13014.png) (7,8-Dichloro-1,2,3,4-tetrahydro-isoquinoline; hydr...)Show InChI InChI=1S/C9H9Cl2N/c10-8-2-1-6-3-4-12-5-7(6)9(8)11/h1-2,12H,3-5H2 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| Purchase
CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem
Patents
Similars
| DrugBank MMDB PDB PubMed
| 3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Smith Kline& French Laboratories
Curated by ChEMBL
| Assay Description Binding affinity for phenylethanolamine N-methyl-transferase was determined. |
J Med Chem 32: 1566-71 (1989)
BindingDB Entry DOI: 10.7270/Q2QZ2BJV |
More data for this Ligand-Target Pair | ![3D 3D](/images/Docked_3d.png) 3D Structure (crystal) |
Phenylethanolamine N-methyltransferase
(Bos taurus (bovine)) | BDBM50018237
![PNG](/data/jpeg/tenK5001/BindingDB_50018237.png) (6,7,8,9-Tetrahydro-3-thia-1,2,8-triaza-cyclopenta[...)Show InChI InChI=1S/C9H9N3S/c1-2-8-9(11-12-13-8)7-5-10-4-3-6(1)7/h1-2,10H,3-5H2 | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
| PubMed
| 8 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Smith Kline& French Laboratories
Curated by ChEMBL
| Assay Description Binding affinity for phenylethanolamine N-methyl-transferase was determined. |
J Med Chem 32: 1566-71 (1989)
BindingDB Entry DOI: 10.7270/Q2QZ2BJV |
More data for this Ligand-Target Pair | |
Phenylethanolamine N-methyltransferase
(Homo sapiens (Human)) | BDBM13014
![PNG](/data/jpeg/tenK1/BindingDB_13014.png) (7,8-Dichloro-1,2,3,4-tetrahydro-isoquinoline; hydr...)Show InChI InChI=1S/C9H9Cl2N/c10-8-2-1-6-3-4-12-5-7(6)9(8)11/h1-2,12H,3-5H2 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| Purchase
CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem
Patents
Similars
| DrugBank MMDB PDB PubMed
| n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibition of rabbit adrenal phenylethanolamine N-methyl-transferase |
J Med Chem 24: 756-9 (1981)
BindingDB Entry DOI: 10.7270/Q2DZ08VH |
More data for this Ligand-Target Pair | ![3D 3D](/images/Docked_3d.png) 3D Structure (crystal) |
Phenylethanolamine N-methyltransferase
(Homo sapiens (Human)) | BDBM50028902
![PNG](/data/jpeg/tenK5002/BindingDB_50028902.png) (7,8-dichloro-2-[2-(7,8-dichloro-1,2,3,4-tetrahydro...)Show SMILES Clc1ccc2CCN(CCN3CCc4ccc(Cl)c(Cl)c4C3)Cc2c1Cl Show InChI InChI=1S/C20H20Cl4N2/c21-17-3-1-13-5-7-25(11-15(13)19(17)23)9-10-26-8-6-14-2-4-18(22)20(24)16(14)12-26/h1-4H,5-12H2 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 80 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibition of rabbit adrenal phenylethanolamine N-methyl-transferase |
J Med Chem 24: 756-9 (1981)
BindingDB Entry DOI: 10.7270/Q2DZ08VH |
More data for this Ligand-Target Pair | |
Phenylethanolamine N-methyltransferase
(Homo sapiens (Human)) | BDBM50028908
![PNG](/data/jpeg/tenK5002/BindingDB_50028908.png) (7,8-dichloro-2-[4-(7,8-dichloro-1,2,3,4-tetrahydro...)Show SMILES Clc1ccc2CCN(CCCCN3CCc4ccc(Cl)c(Cl)c4C3)Cc2c1Cl Show InChI InChI=1S/C22H24Cl4N2/c23-19-5-3-15-7-11-27(13-17(15)21(19)25)9-1-2-10-28-12-8-16-4-6-20(24)22(26)18(16)14-28/h3-6H,1-2,7-14H2 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 100 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibition of rabbit adrenal phenylethanolamine N-methyl-transferase |
J Med Chem 24: 756-9 (1981)
BindingDB Entry DOI: 10.7270/Q2DZ08VH |
More data for this Ligand-Target Pair | ![3D 3D](/images/Docked_3d.png) 3D Structure (docked) |
Phenylethanolamine N-methyltransferase
(Homo sapiens (Human)) | BDBM50028903
![PNG](/data/jpeg/tenK5002/BindingDB_50028903.png) (7,8-dichloro-2-[3-(7,8-dichloro-1,2,3,4-tetrahydro...)Show SMILES Clc1ccc2CCN(CCCN3CCc4ccc(Cl)c(Cl)c4C3)Cc2c1Cl Show InChI InChI=1S/C21H22Cl4N2/c22-18-4-2-14-6-10-26(12-16(14)20(18)24)8-1-9-27-11-7-15-3-5-19(23)21(25)17(15)13-27/h2-5H,1,6-13H2 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 300 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibition of rabbit adrenal phenylethanolamine N-methyl-transferase |
J Med Chem 24: 756-9 (1981)
BindingDB Entry DOI: 10.7270/Q2DZ08VH |
More data for this Ligand-Target Pair | ![3D 3D](/images/Docked_3d.png) 3D Structure (docked) |
Phenylethanolamine N-methyltransferase
(Homo sapiens (Human)) | BDBM50028910
![PNG](/data/jpeg/tenK5002/BindingDB_50028910.png) (7,8-dichloro-2-[6-(7,8-dichloro-1,2,3,4-tetrahydro...)Show SMILES Clc1ccc2CCN(CCCCCCN3CCc4ccc(Cl)c(Cl)c4C3)Cc2c1Cl Show InChI InChI=1S/C24H28Cl4N2/c25-21-7-5-17-9-13-29(15-19(17)23(21)27)11-3-1-2-4-12-30-14-10-18-6-8-22(26)24(28)20(18)16-30/h5-8H,1-4,9-16H2 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibition of rabbit adrenal phenylethanolamine N-methyl-transferase |
J Med Chem 24: 756-9 (1981)
BindingDB Entry DOI: 10.7270/Q2DZ08VH |
More data for this Ligand-Target Pair | ![3D 3D](/images/Docked_3d.png) 3D Structure (docked) |
Phenylethanolamine N-methyltransferase
(Homo sapiens (Human)) | BDBM50028911
![PNG](/data/jpeg/tenK5002/BindingDB_50028911.png) (7,8-dichloro-2-[8-(7,8-dichloro-1,2,3,4-tetrahydro...)Show SMILES Clc1ccc2CCN(CCCCCCCCN3CCc4ccc(Cl)c(Cl)c4C3)Cc2c1Cl Show InChI InChI=1S/C26H32Cl4N2/c27-23-9-7-19-11-15-31(17-21(19)25(23)29)13-5-3-1-2-4-6-14-32-16-12-20-8-10-24(28)26(30)22(20)18-32/h7-10H,1-6,11-18H2 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 2.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibition of rabbit adrenal phenylethanolamine N-methyl-transferase |
J Med Chem 24: 756-9 (1981)
BindingDB Entry DOI: 10.7270/Q2DZ08VH |
More data for this Ligand-Target Pair | ![3D 3D](/images/Docked_3d.png) 3D Structure (docked) |
Phenylethanolamine N-methyltransferase
(Homo sapiens (Human)) | BDBM50028914
![PNG](/data/jpeg/tenK5002/BindingDB_50028914.png) (7,8-dichloro-2-[7-(7,8-dichloro-1,2,3,4-tetrahydro...)Show SMILES Clc1ccc2CCN(CCCCCCCN3CCc4ccc(Cl)c(Cl)c4C3)Cc2c1Cl Show InChI InChI=1S/C25H30Cl4N2/c26-22-8-6-18-10-14-30(16-20(18)24(22)28)12-4-2-1-3-5-13-31-15-11-19-7-9-23(27)25(29)21(19)17-31/h6-9H,1-5,10-17H2 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 2.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibition of rabbit adrenal phenylethanolamine N-methyl-transferase |
J Med Chem 24: 756-9 (1981)
BindingDB Entry DOI: 10.7270/Q2DZ08VH |
More data for this Ligand-Target Pair | ![3D 3D](/images/Docked_3d.png) 3D Structure (docked) |
Phenylethanolamine N-methyltransferase
(Homo sapiens (Human)) | BDBM50028909
![PNG](/data/jpeg/tenK5002/BindingDB_50028909.png) (2-(7,8-Dichloro-3,4-dihydro-1H-isoquinolin-2-yl)-e...)Show InChI InChI=1S/C11H14Cl2N2/c12-10-2-1-8-3-5-15(6-4-14)7-9(8)11(10)13/h1-2H,3-7,14H2 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 2.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibition of rabbit adrenal phenylethanolamine N-methyl-transferase |
J Med Chem 24: 756-9 (1981)
BindingDB Entry DOI: 10.7270/Q2DZ08VH |
More data for this Ligand-Target Pair | ![3D 3D](/images/Docked_3d.png) 3D Structure (docked) |
Phenylethanolamine N-methyltransferase
(Homo sapiens (Human)) | BDBM50028901
![PNG](/data/jpeg/tenK5002/BindingDB_50028901.png) (7,8-Dichloro-2-ethyl-1,2,3,4-tetrahydro-isoquinoli...)Show InChI InChI=1S/C11H13Cl2N/c1-2-14-6-5-8-3-4-10(12)11(13)9(8)7-14/h3-4H,2,5-7H2,1H3 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 2.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibition of rabbit adrenal phenylethanolamine N-methyl-transferase |
J Med Chem 24: 756-9 (1981)
BindingDB Entry DOI: 10.7270/Q2DZ08VH |
More data for this Ligand-Target Pair | ![3D 3D](/images/Docked_3d.png) 3D Structure (docked) |
Polyunsaturated fatty acid 5-lipoxygenase
(Rattus norvegicus) | BDBM50053432
![PNG](/data/jpeg/tenK5005/BindingDB_50053432.png) (2-(4-Methylsulfanyl-phenyl)-3-pyridin-4-yl-6,7-dih...)Show InChI InChI=1S/C18H17N3S/c1-22-15-6-4-13(5-7-15)17-18(14-8-10-19-11-9-14)21-12-2-3-16(21)20-17/h4-11H,2-3,12H2,1H3 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Patents
| Article PubMed
| n/a | n/a | 3.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
SmithKline Beecham Pharmaceuticals
Curated by ChEMBL
| Assay Description Inhibitory concentration against 5-lipoxygenase in rat RBL-1 cells |
J Med Chem 39: 3929-37 (1996)
Article DOI: 10.1021/jm960415o BindingDB Entry DOI: 10.7270/Q29W0G4Z |
More data for this Ligand-Target Pair | |
Polyunsaturated fatty acid 5-lipoxygenase
(Rattus norvegicus) | BDBM50000541
![PNG](/data/jpeg/tenK5000/BindingDB_50000541.png) ((+-)-1-(1-Benzo[b]thien-2-ylethyl)-1-hydroxyurea |...)Show InChI InChI=1S/C11H12N2O2S/c1-7(13(15)11(12)14)10-6-8-4-2-3-5-9(8)16-10/h2-7,15H,1H3,(H2,12,14) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| Purchase
CHEMBL DrugBank MCE PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 3.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
SmithKline Beecham Pharmaceuticals
Curated by ChEMBL
| Assay Description Inhibitory concentration against 5-lipoxygenase in rat RBL-1 cells |
J Med Chem 39: 3929-37 (1996)
Article DOI: 10.1021/jm960415o BindingDB Entry DOI: 10.7270/Q29W0G4Z |
More data for this Ligand-Target Pair | |
Phenylethanolamine N-methyltransferase
(Homo sapiens (Human)) | BDBM50028913
![PNG](/data/jpeg/tenK5002/BindingDB_50028913.png) (7,8-Dichloro-2-propyl-1,2,3,4-tetrahydro-isoquinol...)Show InChI InChI=1S/C12H15Cl2N/c1-2-6-15-7-5-9-3-4-11(13)12(14)10(9)8-15/h3-4H,2,5-8H2,1H3 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 5.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibition of rabbit adrenal phenylethanolamine N-methyl-transferase |
J Med Chem 24: 756-9 (1981)
BindingDB Entry DOI: 10.7270/Q2DZ08VH |
More data for this Ligand-Target Pair | ![3D 3D](/images/Docked_3d.png) 3D Structure (docked) |
Prostaglandin G/H synthase 1
(Ovis aries (Sheep)) | BDBM14832
![PNG](/data/jpeg/tenK1/BindingDB_14832.png) (3-(4-fluorophenyl)-2-pyridin-4-yl-6-thia-1,4-diaza...)Show InChI InChI=1S/C16H12FN3S/c17-13-3-1-11(2-4-13)14-15(12-5-7-18-8-6-12)20-9-10-21-16(20)19-14/h1-8H,9-10H2 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| Purchase
CHEMBL MCE PC cid PC sid PDB UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 5.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
SmithKline Beecham Pharmaceuticals
Curated by ChEMBL
| Assay Description Inhibitory concentration against Prostaglandin H2 synthase 1 (PGHS-1) from ram seminal vesicle |
J Med Chem 39: 3929-37 (1996)
Article DOI: 10.1021/jm960415o BindingDB Entry DOI: 10.7270/Q29W0G4Z |
More data for this Ligand-Target Pair | |
Phenylethanolamine N-methyltransferase
(Homo sapiens (Human)) | BDBM50028912
![PNG](/data/jpeg/tenK5002/BindingDB_50028912.png) (2-Benzyl-7,8-dichloro-1,2,3,4-tetrahydro-isoquinol...)Show InChI InChI=1S/C16H15Cl2N/c17-15-7-6-13-8-9-19(11-14(13)16(15)18)10-12-4-2-1-3-5-12/h1-7H,8-11H2 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 7.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibition of rabbit adrenal phenylethanolamine N-methyl-transferase |
J Med Chem 24: 756-9 (1981)
BindingDB Entry DOI: 10.7270/Q2DZ08VH |
More data for this Ligand-Target Pair | ![3D 3D](/images/Docked_3d.png) 3D Structure (docked) |
Phenylethanolamine N-methyltransferase
(Homo sapiens (Human)) | BDBM50028906
![PNG](/data/jpeg/tenK5002/BindingDB_50028906.png) (7,8-dichloro-2-[5-(7,8-dichloro-1,2,3,4-tetrahydro...)Show SMILES Clc1ccc2CCN(CCCCCN3CCc4ccc(Cl)c(Cl)c4C3)Cc2c1Cl Show InChI InChI=1S/C23H26Cl4N2/c24-20-6-4-16-8-12-28(14-18(16)22(20)26)10-2-1-3-11-29-13-9-17-5-7-21(25)23(27)19(17)15-29/h4-7H,1-3,8-15H2 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibition of rabbit adrenal phenylethanolamine N-methyl-transferase |
J Med Chem 24: 756-9 (1981)
BindingDB Entry DOI: 10.7270/Q2DZ08VH |
More data for this Ligand-Target Pair | ![3D 3D](/images/Docked_3d.png) 3D Structure (docked) |
Polyunsaturated fatty acid 5-lipoxygenase
(Rattus norvegicus) | BDBM14832
![PNG](/data/jpeg/tenK1/BindingDB_14832.png) (3-(4-fluorophenyl)-2-pyridin-4-yl-6-thia-1,4-diaza...)Show InChI InChI=1S/C16H12FN3S/c17-13-3-1-11(2-4-13)14-15(12-5-7-18-8-6-12)20-9-10-21-16(20)19-14/h1-8H,9-10H2 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| Purchase
CHEMBL MCE PC cid PC sid PDB UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
SmithKline Beecham Pharmaceuticals
Curated by ChEMBL
| Assay Description Inhibitory concentration against 5-lipoxygenase in rat RBL-1 cells |
J Med Chem 39: 3929-37 (1996)
Article DOI: 10.1021/jm960415o BindingDB Entry DOI: 10.7270/Q29W0G4Z |
More data for this Ligand-Target Pair | |
Phenylethanolamine N-methyltransferase
(Homo sapiens (Human)) | BDBM13014
![PNG](/data/jpeg/tenK1/BindingDB_13014.png) (7,8-Dichloro-1,2,3,4-tetrahydro-isoquinoline; hydr...)Show InChI InChI=1S/C9H9Cl2N/c10-8-2-1-6-3-4-12-5-7(6)9(8)11/h1-2,12H,3-5H2 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| Purchase
CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem
Patents
Similars
| DrugBank MMDB PDB PubMed
| n/a | n/a | 1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description In vitro inhibitory activity against human phenylethanolamine N-methyl-transferase |
J Med Chem 24: 756-9 (1981)
BindingDB Entry DOI: 10.7270/Q2DZ08VH |
More data for this Ligand-Target Pair | ![3D 3D](/images/Docked_3d.png) 3D Structure (crystal) |
Prostaglandin G/H synthase 1
(Ovis aries (Sheep)) | BDBM50053430
![PNG](/data/jpeg/tenK5005/BindingDB_50053430.png) (4-[3-Cyclopropyl-5-(4-fluoro-phenyl)-3H-imidazol-4...)Show InChI InChI=1S/C17H14FN3/c18-14-3-1-12(2-4-14)16-17(13-7-9-19-10-8-13)21(11-20-16)15-5-6-15/h1-4,7-11,15H,5-6H2 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 1.60E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
SmithKline Beecham Pharmaceuticals
Curated by ChEMBL
| Assay Description Inhibitory concentration against Prostaglandin H2 synthase 1 (PGHS-1) from ram seminal vesicle |
J Med Chem 39: 3929-37 (1996)
Article DOI: 10.1021/jm960415o BindingDB Entry DOI: 10.7270/Q29W0G4Z |
More data for this Ligand-Target Pair | |
Prostaglandin G/H synthase 1
(Ovis aries (Sheep)) | BDBM50339185
![PNG](/data/jpeg/tenK5033/BindingDB_50339185.png) ((2S)-2-(6-methoxynaphthalen-2-yl)propanoic acid | ...)Show InChI InChI=1S/C14H14O3/c1-9(14(15)16)10-3-4-12-8-13(17-2)6-5-11(12)7-10/h3-9H,1-2H3,(H,15,16)/t9-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| Purchase
CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 2.10E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
SmithKline Beecham Pharmaceuticals
Curated by ChEMBL
| Assay Description Inhibitory concentration against Prostaglandin H2 synthase 1 (PGHS-1) from ram seminal vesicle |
J Med Chem 39: 3929-37 (1996)
Article DOI: 10.1021/jm960415o BindingDB Entry DOI: 10.7270/Q29W0G4Z |
More data for this Ligand-Target Pair | |
Phenylethanolamine N-methyltransferase
(Homo sapiens (Human)) | BDBM50028905
![PNG](/data/jpeg/tenK5002/BindingDB_50028905.png) (7,8-Dichloro-2-(6-phenyl-hexyl)-1,2,3,4-tetrahydro...)Show InChI InChI=1S/C21H25Cl2N/c22-20-12-11-18-13-15-24(16-19(18)21(20)23)14-7-2-1-4-8-17-9-5-3-6-10-17/h3,5-6,9-12H,1-2,4,7-8,13-16H2 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 5.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibition of rabbit adrenal phenylethanolamine N-methyl-transferase |
J Med Chem 24: 756-9 (1981)
BindingDB Entry DOI: 10.7270/Q2DZ08VH |
More data for this Ligand-Target Pair | ![3D 3D](/images/Docked_3d.png) 3D Structure (docked) |
Prostaglandin G/H synthase 1
(Ovis aries (Sheep)) | BDBM15237
![PNG](/data/jpeg/tenK1/BindingDB_15237.png) (4-[1-(cyclopropylmethyl)-4-(4-fluorophenyl)-1H-imi...)Show InChI InChI=1S/C18H16FN3/c19-16-5-3-14(4-6-16)17-18(15-7-9-20-10-8-15)22(12-21-17)11-13-1-2-13/h3-10,12-13H,1-2,11H2 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 5.10E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
SmithKline Beecham Pharmaceuticals
Curated by ChEMBL
| Assay Description Inhibitory concentration against Prostaglandin H2 synthase 1 (PGHS-1) from ram seminal vesicle |
J Med Chem 39: 3929-37 (1996)
Article DOI: 10.1021/jm960415o BindingDB Entry DOI: 10.7270/Q29W0G4Z |
More data for this Ligand-Target Pair | |
Polyunsaturated fatty acid 5-lipoxygenase
(Rattus norvegicus) | BDBM50053430
![PNG](/data/jpeg/tenK5005/BindingDB_50053430.png) (4-[3-Cyclopropyl-5-(4-fluoro-phenyl)-3H-imidazol-4...)Show InChI InChI=1S/C17H14FN3/c18-14-3-1-12(2-4-14)16-17(13-7-9-19-10-8-13)21(11-20-16)15-5-6-15/h1-4,7-11,15H,5-6H2 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 6.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
SmithKline Beecham Pharmaceuticals
Curated by ChEMBL
| Assay Description Inhibitory concentration against 5-lipoxygenase in rat RBL-1 cells |
J Med Chem 39: 3929-37 (1996)
Article DOI: 10.1021/jm960415o BindingDB Entry DOI: 10.7270/Q29W0G4Z |
More data for this Ligand-Target Pair | |
Polyunsaturated fatty acid 5-lipoxygenase
(Rattus norvegicus) | BDBM15237
![PNG](/data/jpeg/tenK1/BindingDB_15237.png) (4-[1-(cyclopropylmethyl)-4-(4-fluorophenyl)-1H-imi...)Show InChI InChI=1S/C18H16FN3/c19-16-5-3-14(4-6-16)17-18(15-7-9-20-10-8-15)22(12-21-17)11-13-1-2-13/h3-10,12-13H,1-2,11H2 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
SmithKline Beecham Pharmaceuticals
Curated by ChEMBL
| Assay Description Inhibitory concentration against 5-lipoxygenase in rat RBL-1 cells |
J Med Chem 39: 3929-37 (1996)
Article DOI: 10.1021/jm960415o BindingDB Entry DOI: 10.7270/Q29W0G4Z |
More data for this Ligand-Target Pair | |
Polyunsaturated fatty acid 5-lipoxygenase
(Rattus norvegicus) | BDBM50053424
![PNG](/data/jpeg/tenK5005/BindingDB_50053424.png) (4-{3-[4-(4-Fluoro-phenyl)-5-pyridin-4-yl-imidazol-...)Show InChI InChI=1S/C21H23FN4O/c22-19-4-2-17(3-5-19)20-21(18-6-8-23-9-7-18)26(16-24-20)11-1-10-25-12-14-27-15-13-25/h2-9,16H,1,10-15H2 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
SmithKline Beecham Pharmaceuticals
Curated by ChEMBL
| Assay Description Inhibitory concentration against 5-lipoxygenase in rat RBL-1 cells |
J Med Chem 39: 3929-37 (1996)
Article DOI: 10.1021/jm960415o BindingDB Entry DOI: 10.7270/Q29W0G4Z |
More data for this Ligand-Target Pair | |
Prostaglandin G/H synthase 1
(Ovis aries (Sheep)) | BDBM50053424
![PNG](/data/jpeg/tenK5005/BindingDB_50053424.png) (4-{3-[4-(4-Fluoro-phenyl)-5-pyridin-4-yl-imidazol-...)Show InChI InChI=1S/C21H23FN4O/c22-19-4-2-17(3-5-19)20-21(18-6-8-23-9-7-18)26(16-24-20)11-1-10-25-12-14-27-15-13-25/h2-9,16H,1,10-15H2 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
SmithKline Beecham Pharmaceuticals
Curated by ChEMBL
| Assay Description Inhibitory concentration against Prostaglandin H2 synthase 1 (PGHS-1) from ram seminal vesicle |
J Med Chem 39: 3929-37 (1996)
Article DOI: 10.1021/jm960415o BindingDB Entry DOI: 10.7270/Q29W0G4Z |
More data for this Ligand-Target Pair | |
Polyunsaturated fatty acid 5-lipoxygenase
(Rattus norvegicus) | BDBM50053410
![PNG](/data/jpeg/tenK5005/BindingDB_50053410.png) (4-(4-Fluorophenyl)-5-(pyridin-4-yl)-1H-imidazole |...)Show InChI InChI=1S/C14H10FN3/c15-12-3-1-10(2-4-12)13-14(18-9-17-13)11-5-7-16-8-6-11/h1-9H,(H,17,18) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
SmithKline Beecham Pharmaceuticals
Curated by ChEMBL
| Assay Description Inhibitory concentration against 5-lipoxygenase in rat RBL-1 cells |
J Med Chem 39: 3929-37 (1996)
Article DOI: 10.1021/jm960415o BindingDB Entry DOI: 10.7270/Q29W0G4Z |
More data for this Ligand-Target Pair | |
Polyunsaturated fatty acid 5-lipoxygenase
(Rattus norvegicus) | BDBM50053412
![PNG](/data/jpeg/tenK5005/BindingDB_50053412.png) (4-{3-[4-(3,4-Dichloro-phenyl)-5-pyridin-4-yl-imida...)Show SMILES Clc1ccc(cc1Cl)-c1ncn(CCCN2CCOCC2)c1-c1ccncc1 Show InChI InChI=1S/C21H22Cl2N4O/c22-18-3-2-17(14-19(18)23)20-21(16-4-6-24-7-5-16)27(15-25-20)9-1-8-26-10-12-28-13-11-26/h2-7,14-15H,1,8-13H2 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
SmithKline Beecham Pharmaceuticals
Curated by ChEMBL
| Assay Description Inhibitory concentration against 5-lipoxygenase in rat RBL-1 cells |
J Med Chem 39: 3929-37 (1996)
Article DOI: 10.1021/jm960415o BindingDB Entry DOI: 10.7270/Q29W0G4Z |
More data for this Ligand-Target Pair | |
Prostaglandin G/H synthase 1
(Ovis aries (Sheep)) | BDBM50053410
![PNG](/data/jpeg/tenK5005/BindingDB_50053410.png) (4-(4-Fluorophenyl)-5-(pyridin-4-yl)-1H-imidazole |...)Show InChI InChI=1S/C14H10FN3/c15-12-3-1-10(2-4-12)13-14(18-9-17-13)11-5-7-16-8-6-11/h1-9H,(H,17,18) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
SmithKline Beecham Pharmaceuticals
Curated by ChEMBL
| Assay Description Inhibitory concentration against Prostaglandin H2 synthase 1 (PGHS-1) from ram seminal vesicle |
J Med Chem 39: 3929-37 (1996)
Article DOI: 10.1021/jm960415o BindingDB Entry DOI: 10.7270/Q29W0G4Z |
More data for this Ligand-Target Pair | |
Prostaglandin G/H synthase 1
(Ovis aries (Sheep)) | BDBM50053432
![PNG](/data/jpeg/tenK5005/BindingDB_50053432.png) (2-(4-Methylsulfanyl-phenyl)-3-pyridin-4-yl-6,7-dih...)Show InChI InChI=1S/C18H17N3S/c1-22-15-6-4-13(5-7-15)17-18(14-8-10-19-11-9-14)21-12-2-3-16(21)20-17/h4-11H,2-3,12H2,1H3 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Patents
| Article PubMed
| n/a | n/a | 1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
SmithKline Beecham Pharmaceuticals
Curated by ChEMBL
| Assay Description Inhibitory concentration against Prostaglandin H2 synthase 1 (PGHS-1) from ram seminal vesicle |
J Med Chem 39: 3929-37 (1996)
Article DOI: 10.1021/jm960415o BindingDB Entry DOI: 10.7270/Q29W0G4Z |
More data for this Ligand-Target Pair | |
Prostaglandin G/H synthase 1
(Ovis aries (Sheep)) | BDBM50053412
![PNG](/data/jpeg/tenK5005/BindingDB_50053412.png) (4-{3-[4-(3,4-Dichloro-phenyl)-5-pyridin-4-yl-imida...)Show SMILES Clc1ccc(cc1Cl)-c1ncn(CCCN2CCOCC2)c1-c1ccncc1 Show InChI InChI=1S/C21H22Cl2N4O/c22-18-3-2-17(14-19(18)23)20-21(16-4-6-24-7-5-16)27(15-25-20)9-1-8-26-10-12-28-13-11-26/h2-7,14-15H,1,8-13H2 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
SmithKline Beecham Pharmaceuticals
Curated by ChEMBL
| Assay Description Inhibitory concentration against Prostaglandin H2 synthase 1 (PGHS-1) from ram seminal vesicle |
J Med Chem 39: 3929-37 (1996)
Article DOI: 10.1021/jm960415o BindingDB Entry DOI: 10.7270/Q29W0G4Z |
More data for this Ligand-Target Pair | |
Phenylethanolamine N-methyltransferase
(Homo sapiens (Human)) | BDBM50028907
![PNG](/data/jpeg/tenK5002/BindingDB_50028907.png) (6-(7,8-Dichloro-3,4-dihydro-1H-isoquinolin-2-yl)-h...)Show InChI InChI=1S/C15H21Cl2NO/c16-14-6-5-12-7-9-18(11-13(12)15(14)17)8-3-1-2-4-10-19/h5-6,19H,1-4,7-11H2 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibition of rabbit adrenal phenylethanolamine N-methyl-transferase |
J Med Chem 24: 756-9 (1981)
BindingDB Entry DOI: 10.7270/Q2DZ08VH |
More data for this Ligand-Target Pair | |
Phenylethanolamine N-methyltransferase
(Homo sapiens (Human)) | BDBM50028904
![PNG](/data/jpeg/tenK5002/BindingDB_50028904.png) (2-(6-Bromo-hexyl)-7,8-dichloro-1,2,3,4-tetrahydro-...)Show InChI InChI=1S/C15H20BrCl2N/c16-8-3-1-2-4-9-19-10-7-12-5-6-14(17)15(18)13(12)11-19/h5-6H,1-4,7-11H2 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibition of rabbit adrenal phenylethanolamine N-methyl-transferase |
J Med Chem 24: 756-9 (1981)
BindingDB Entry DOI: 10.7270/Q2DZ08VH |
More data for this Ligand-Target Pair | |