Compile Data Set for Download or QSAR

Found 53 hits with Last Name = 'bove' and Initial = 'se'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat))	BDBM50220087 (2-(3,5-dichlorophenyl)-7-methylpyrido[2,3-d]pyrimi...) Show SMILES Cc1ccc2cnc(nc2n1)-c1cc(Cl)cc(Cl)c1 Show InChI InChI=1S/C14H9Cl2N3/c1-8-2-3-9-7-17-13(19-14(9)18-8)10-4-11(15)6-12(16)5-10/h2-7H,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.720	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research & Development Curated by ChEMBL					Assay Description Antagonistic activity at rat mGluR5 expressed in CHO cells assessed as inhibition of quisqualate stimulated calcium mobilization by FLIPR technology				Bioorg Med Chem Lett 17: 5396-9 (2007) Article DOI: 10.1016/j.bmcl.2007.07.047 BindingDB Entry DOI: 10.7270/Q2JH3KWK
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat))	BDBM50220096 (3-methoxy-5-(7-methylpyrido[2,3-d]pyrimidin-2-yl)b...) Show SMILES COc1cc(cc(c1)-c1ncc2ccc(C)nc2n1)C#N Show InChI InChI=1S/C16H12N4O/c1-10-3-4-12-9-18-15(20-16(12)19-10)13-5-11(8-17)6-14(7-13)21-2/h3-7,9H,1-2H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.20	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research & Development Curated by ChEMBL					Assay Description Antagonistic activity at rat mGluR5 expressed in CHO cells assessed as inhibition of quisqualate stimulated calcium mobilization by FLIPR technology				Bioorg Med Chem Lett 17: 5396-9 (2007) Article DOI: 10.1016/j.bmcl.2007.07.047 BindingDB Entry DOI: 10.7270/Q2JH3KWK
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat))	BDBM50220088 (3-methoxy-5-(pyrido[2,3-d]pyrimidin-2-yl)benzonitr...) Show SMILES COc1cc(cc(c1)-c1ncc2cccnc2n1)C#N Show InChI InChI=1S/C15H10N4O/c1-20-13-6-10(8-16)5-12(7-13)15-18-9-11-3-2-4-17-14(11)19-15/h2-7,9H,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.95	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research & Development Curated by ChEMBL					Assay Description Antagonistic activity at rat mGluR5 expressed in CHO cells assessed as inhibition of quisqualate stimulated calcium mobilization by FLIPR technology				Bioorg Med Chem Lett 17: 5396-9 (2007) Article DOI: 10.1016/j.bmcl.2007.07.047 BindingDB Entry DOI: 10.7270/Q2JH3KWK
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat))	BDBM50224920 (3-methoxy-5-(2-methyl-1,6-naphthyridin-7-yl)benzon...) Show SMILES COc1cc(cc(c1)-c1cc2nc(C)ccc2cn1)C#N Show InChI InChI=1S/C17H13N3O/c1-11-3-4-13-10-19-16(8-17(13)20-11)14-5-12(9-18)6-15(7-14)21-2/h3-8,10H,1-2H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	6.19	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research & Development Curated by ChEMBL					Assay Description Antagonist activity at rat mGlu5 receptor expressed in CHO cells assessed as inhibition of quisqualate-stimulated calcium mobilization				Bioorg Med Chem Lett 17: 6525-8 (2007) Article DOI: 10.1016/j.bmcl.2007.09.083 BindingDB Entry DOI: 10.7270/Q2V40TXS
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat))	BDBM50220085 (2-(3-bromophenyl)-7-methylpyrido[2,3-d]pyrimidine ...) Show SMILES Cc1ccc2cnc(nc2n1)-c1cccc(Br)c1 Show InChI InChI=1S/C14H10BrN3/c1-9-5-6-11-8-16-13(18-14(11)17-9)10-3-2-4-12(15)7-10/h2-8H,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	38	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research & Development Curated by ChEMBL					Assay Description Antagonistic activity at rat mGluR5 expressed in CHO cells assessed as inhibition of quisqualate stimulated calcium mobilization by FLIPR technology				Bioorg Med Chem Lett 17: 5396-9 (2007) Article DOI: 10.1016/j.bmcl.2007.07.047 BindingDB Entry DOI: 10.7270/Q2JH3KWK
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat))	BDBM50220076 (2-(3-fluoro-5-methylphenyl)-7-methylpyrido[2,3-d]p...) Show SMILES Cc1cc(F)cc(c1)-c1ncc2ccc(C)nc2n1 Show InChI InChI=1S/C15H12FN3/c1-9-5-12(7-13(16)6-9)14-17-8-11-4-3-10(2)18-15(11)19-14/h3-8H,1-2H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	39.7	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research & Development Curated by ChEMBL					Assay Description Antagonistic activity at rat mGluR5 expressed in CHO cells assessed as inhibition of quisqualate stimulated calcium mobilization by FLIPR technology				Bioorg Med Chem Lett 17: 5396-9 (2007) Article DOI: 10.1016/j.bmcl.2007.07.047 BindingDB Entry DOI: 10.7270/Q2JH3KWK
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat))	BDBM50224924 (2-(3,4-dimethylphenyl)-1,8-naphthyridine | CHEMBL2...) Show SMILES Cc1ccc(cc1C)-c1ccc2cccnc2n1 Show InChI InChI=1S/C16H14N2/c1-11-5-6-14(10-12(11)2)15-8-7-13-4-3-9-17-16(13)18-15/h3-10H,1-2H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	45	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research & Development Curated by ChEMBL					Assay Description Antagonist activity at rat mGlu5 receptor expressed in CHO cells assessed as inhibition of quisqualate-stimulated calcium mobilization				Bioorg Med Chem Lett 17: 6525-8 (2007) Article DOI: 10.1016/j.bmcl.2007.09.083 BindingDB Entry DOI: 10.7270/Q2V40TXS
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat))	BDBM50224929 (2-(3-bromophenyl)-7-methyl-1,8-naphthyridine | CHE...) Show SMILES Cc1ccc2ccc(nc2n1)-c1cccc(Br)c1 Show InChI InChI=1S/C15H11BrN2/c1-10-5-6-11-7-8-14(18-15(11)17-10)12-3-2-4-13(16)9-12/h2-9H,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	47.9	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research & Development Curated by ChEMBL					Assay Description Antagonist activity at rat mGlu5 receptor expressed in CHO cells assessed as inhibition of quisqualate-stimulated calcium mobilization				Bioorg Med Chem Lett 17: 6525-8 (2007) Article DOI: 10.1016/j.bmcl.2007.09.083 BindingDB Entry DOI: 10.7270/Q2V40TXS
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat))	BDBM50224922 (2-(3,5-dimethoxyphenyl)-7-methyl-1,8-naphthyridine...) Show SMILES COc1cc(OC)cc(c1)-c1ccc2ccc(C)nc2n1 Show InChI InChI=1S/C17H16N2O2/c1-11-4-5-12-6-7-16(19-17(12)18-11)13-8-14(20-2)10-15(9-13)21-3/h4-10H,1-3H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	51.7	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research & Development Curated by ChEMBL					Assay Description Antagonist activity at rat mGlu5 receptor expressed in CHO cells assessed as inhibition of quisqualate-stimulated calcium mobilization				Bioorg Med Chem Lett 17: 6525-8 (2007) Article DOI: 10.1016/j.bmcl.2007.09.083 BindingDB Entry DOI: 10.7270/Q2V40TXS
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat))	BDBM50220084 (7-methyl-2-m-tolylpyrido[2,3-d]pyrimidine | CHEMBL...) Show SMILES Cc1cccc(c1)-c1ncc2ccc(C)nc2n1 Show InChI InChI=1S/C15H13N3/c1-10-4-3-5-12(8-10)14-16-9-13-7-6-11(2)17-15(13)18-14/h3-9H,1-2H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	53	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research & Development Curated by ChEMBL					Assay Description Antagonistic activity at rat mGluR5 expressed in CHO cells assessed as inhibition of quisqualate stimulated calcium mobilization by FLIPR technology				Bioorg Med Chem Lett 17: 5396-9 (2007) Article DOI: 10.1016/j.bmcl.2007.07.047 BindingDB Entry DOI: 10.7270/Q2JH3KWK
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat))	BDBM50224932 (3-methoxy-5-(1,5-naphthyridin-3-yl)benzonitrile | ...) Show SMILES COc1cc(cc(c1)-c1cnc2cccnc2c1)C#N Show InChI InChI=1S/C16H11N3O/c1-20-14-6-11(9-17)5-12(7-14)13-8-16-15(19-10-13)3-2-4-18-16/h2-8,10H,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	55	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research & Development Curated by ChEMBL					Assay Description Antagonist activity at rat mGlu5 receptor expressed in CHO cells assessed as inhibition of quisqualate-stimulated calcium mobilization				Bioorg Med Chem Lett 17: 6525-8 (2007) Article DOI: 10.1016/j.bmcl.2007.09.083 BindingDB Entry DOI: 10.7270/Q2V40TXS
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat))	BDBM50224941 (2-(3,5-dimethoxyphenyl)-1,8-naphthyridine | CHEMBL...) Show SMILES COc1cc(OC)cc(c1)-c1ccc2cccnc2n1 Show InChI InChI=1S/C16H14N2O2/c1-19-13-8-12(9-14(10-13)20-2)15-6-5-11-4-3-7-17-16(11)18-15/h3-10H,1-2H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	67	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research & Development Curated by ChEMBL					Assay Description Antagonist activity at rat mGlu5 receptor expressed in CHO cells assessed as inhibition of quisqualate-stimulated calcium mobilization				Bioorg Med Chem Lett 17: 6525-8 (2007) Article DOI: 10.1016/j.bmcl.2007.09.083 BindingDB Entry DOI: 10.7270/Q2V40TXS
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat))	BDBM50224940 (3-methoxy-5-(1,6-naphthyridin-7-yl)benzonitrile | ...) Show SMILES COc1cc(cc(c1)-c1cc2ncccc2cn1)C#N Show InChI InChI=1S/C16H11N3O/c1-20-14-6-11(9-17)5-13(7-14)16-8-15-12(10-19-16)3-2-4-18-15/h2-8,10H,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	68	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research & Development Curated by ChEMBL					Assay Description Antagonist activity at rat mGlu5 receptor expressed in CHO cells assessed as inhibition of quisqualate-stimulated calcium mobilization				Bioorg Med Chem Lett 17: 6525-8 (2007) Article DOI: 10.1016/j.bmcl.2007.09.083 BindingDB Entry DOI: 10.7270/Q2V40TXS
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat))	BDBM50224923 (3-(1,8-naphthyridin-2-yl)benzonitrile | CHEMBL2353...) Show SMILES N#Cc1cccc(c1)-c1ccc2cccnc2n1 Show InChI InChI=1S/C15H9N3/c16-10-11-3-1-4-13(9-11)14-7-6-12-5-2-8-17-15(12)18-14/h1-9H	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	115	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research & Development Curated by ChEMBL					Assay Description Antagonist activity at rat mGlu5 receptor expressed in CHO cells assessed as inhibition of quisqualate-stimulated calcium mobilization				Bioorg Med Chem Lett 17: 6525-8 (2007) Article DOI: 10.1016/j.bmcl.2007.09.083 BindingDB Entry DOI: 10.7270/Q2V40TXS
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat))	BDBM50224936 (2-(3-chlorophenyl)-7-methyl-1,8-naphthyridine | CH...) Show SMILES Cc1ccc2ccc(nc2n1)-c1cccc(Cl)c1 Show InChI InChI=1S/C15H11ClN2/c1-10-5-6-11-7-8-14(18-15(11)17-10)12-3-2-4-13(16)9-12/h2-9H,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	177	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research & Development Curated by ChEMBL					Assay Description Antagonist activity at rat mGlu5 receptor expressed in CHO cells assessed as inhibition of quisqualate-stimulated calcium mobilization				Bioorg Med Chem Lett 17: 6525-8 (2007) Article DOI: 10.1016/j.bmcl.2007.09.083 BindingDB Entry DOI: 10.7270/Q2V40TXS
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat))	BDBM50220079 (2-(3,5-dimethoxyphenyl)-7-methylpyrido[2,3-d]pyrim...) Show SMILES COc1cc(OC)cc(c1)-c1ncc2ccc(C)nc2n1 Show InChI InChI=1S/C16H15N3O2/c1-10-4-5-11-9-17-15(19-16(11)18-10)12-6-13(20-2)8-14(7-12)21-3/h4-9H,1-3H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	179	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research & Development Curated by ChEMBL					Assay Description Antagonistic activity at rat mGluR5 expressed in CHO cells assessed as inhibition of quisqualate stimulated calcium mobilization by FLIPR technology				Bioorg Med Chem Lett 17: 5396-9 (2007) Article DOI: 10.1016/j.bmcl.2007.07.047 BindingDB Entry DOI: 10.7270/Q2JH3KWK
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat))	BDBM50224925 (2-(3,5-difluorophenyl)-7-methyl-1,8-naphthyridine ...) Show SMILES Cc1ccc2ccc(nc2n1)-c1cc(F)cc(F)c1 Show InChI InChI=1S/C15H10F2N2/c1-9-2-3-10-4-5-14(19-15(10)18-9)11-6-12(16)8-13(17)7-11/h2-8H,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	181	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research & Development Curated by ChEMBL					Assay Description Antagonist activity at rat mGlu5 receptor expressed in CHO cells assessed as inhibition of quisqualate-stimulated calcium mobilization				Bioorg Med Chem Lett 17: 6525-8 (2007) Article DOI: 10.1016/j.bmcl.2007.09.083 BindingDB Entry DOI: 10.7270/Q2V40TXS
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat))	BDBM50224917 (2-m-tolyl-1,8-naphthyridine | CHEMBL395902) Show SMILES Cc1cccc(c1)-c1ccc2cccnc2n1 Show InChI InChI=1S/C15H12N2/c1-11-4-2-5-13(10-11)14-8-7-12-6-3-9-16-15(12)17-14/h2-10H,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	225	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research & Development Curated by ChEMBL					Assay Description Antagonist activity at rat mGlu5 receptor expressed in CHO cells assessed as inhibition of quisqualate-stimulated calcium mobilization				Bioorg Med Chem Lett 17: 6525-8 (2007) Article DOI: 10.1016/j.bmcl.2007.09.083 BindingDB Entry DOI: 10.7270/Q2V40TXS
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat))	BDBM50220077 (2-(3,5-dichlorophenyl)pyrido[2,3-d]pyrimidine | CH...) Show SMILES Clc1cc(Cl)cc(c1)-c1ncc2cccnc2n1 Show InChI InChI=1S/C13H7Cl2N3/c14-10-4-9(5-11(15)6-10)13-17-7-8-2-1-3-16-12(8)18-13/h1-7H	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	228	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research & Development Curated by ChEMBL					Assay Description Antagonistic activity at rat mGluR5 expressed in CHO cells assessed as inhibition of quisqualate stimulated calcium mobilization by FLIPR technology				Bioorg Med Chem Lett 17: 5396-9 (2007) Article DOI: 10.1016/j.bmcl.2007.07.047 BindingDB Entry DOI: 10.7270/Q2JH3KWK
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat))	BDBM50220094 (3-(7-methylpyrido[2,3-d]pyrimidin-2-yl)benzonitril...) Show SMILES Cc1ccc2cnc(nc2n1)-c1cccc(c1)C#N Show InChI InChI=1S/C15H10N4/c1-10-5-6-13-9-17-14(19-15(13)18-10)12-4-2-3-11(7-12)8-16/h2-7,9H,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	240	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research & Development Curated by ChEMBL					Assay Description Antagonistic activity at rat mGluR5 expressed in CHO cells assessed as inhibition of quisqualate stimulated calcium mobilization by FLIPR technology				Bioorg Med Chem Lett 17: 5396-9 (2007) Article DOI: 10.1016/j.bmcl.2007.07.047 BindingDB Entry DOI: 10.7270/Q2JH3KWK
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat))	BDBM50224939 (2-methyl-7-m-tolyl-1,8-naphthyridine | CHEMBL23562...) Show SMILES Cc1cccc(c1)-c1ccc2ccc(C)nc2n1 Show InChI InChI=1S/C16H14N2/c1-11-4-3-5-14(10-11)15-9-8-13-7-6-12(2)17-16(13)18-15/h3-10H,1-2H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	277	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research & Development Curated by ChEMBL					Assay Description Antagonist activity at rat mGlu5 receptor expressed in CHO cells assessed as inhibition of quisqualate-stimulated calcium mobilization				Bioorg Med Chem Lett 17: 6525-8 (2007) Article DOI: 10.1016/j.bmcl.2007.09.083 BindingDB Entry DOI: 10.7270/Q2V40TXS
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat))	BDBM50220082 (2-(3-fluoro-5-methylphenyl)pyrido[2,3-d]pyrimidine...) Show SMILES Cc1cc(F)cc(c1)-c1ncc2cccnc2n1 Show InChI InChI=1S/C14H10FN3/c1-9-5-11(7-12(15)6-9)14-17-8-10-3-2-4-16-13(10)18-14/h2-8H,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	321	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research & Development Curated by ChEMBL					Assay Description Antagonistic activity at rat mGluR5 expressed in CHO cells assessed as inhibition of quisqualate stimulated calcium mobilization by FLIPR technology				Bioorg Med Chem Lett 17: 5396-9 (2007) Article DOI: 10.1016/j.bmcl.2007.07.047 BindingDB Entry DOI: 10.7270/Q2JH3KWK
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat))	BDBM50220083 (2-(3-bromophenyl)pyrido[2,3-d]pyrimidine | CHEMBL2...) Show SMILES Brc1cccc(c1)-c1ncc2cccnc2n1 Show InChI InChI=1S/C13H8BrN3/c14-11-5-1-3-9(7-11)12-16-8-10-4-2-6-15-13(10)17-12/h1-8H	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	333	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research & Development Curated by ChEMBL					Assay Description Antagonistic activity at rat mGluR5 expressed in CHO cells assessed as inhibition of quisqualate stimulated calcium mobilization by FLIPR technology				Bioorg Med Chem Lett 17: 5396-9 (2007) Article DOI: 10.1016/j.bmcl.2007.07.047 BindingDB Entry DOI: 10.7270/Q2JH3KWK
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat))	BDBM50224926 (7-(3,5-dimethoxyphenyl)-2-methyl-1,6-naphthyridine...) Show SMILES COc1cc(OC)cc(c1)-c1cc2nc(C)ccc2cn1 Show InChI InChI=1S/C17H16N2O2/c1-11-4-5-12-10-18-16(9-17(12)19-11)13-6-14(20-2)8-15(7-13)21-3/h4-10H,1-3H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	345	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research & Development Curated by ChEMBL					Assay Description Antagonist activity at rat mGlu5 receptor expressed in CHO cells assessed as inhibition of quisqualate-stimulated calcium mobilization				Bioorg Med Chem Lett 17: 6525-8 (2007) Article DOI: 10.1016/j.bmcl.2007.09.083 BindingDB Entry DOI: 10.7270/Q2V40TXS
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat))	BDBM50224921 (3-(methoxymethoxy)-5-(1,6-naphthyridin-7-yl)benzon...) Show SMILES COCOc1cc(cc(c1)-c1cc2ncccc2cn1)C#N Show InChI InChI=1S/C17H13N3O2/c1-21-11-22-15-6-12(9-18)5-14(7-15)17-8-16-13(10-20-17)3-2-4-19-16/h2-8,10H,11H2,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	468	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research & Development Curated by ChEMBL					Assay Description Antagonist activity at rat mGlu5 receptor expressed in CHO cells assessed as inhibition of quisqualate-stimulated calcium mobilization				Bioorg Med Chem Lett 17: 6525-8 (2007) Article DOI: 10.1016/j.bmcl.2007.09.083 BindingDB Entry DOI: 10.7270/Q2V40TXS
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat))	BDBM50224931 (3-(7-methyl-1,8-naphthyridin-2-yl)benzonitrile | C...) Show SMILES Cc1ccc2ccc(nc2n1)-c1cccc(c1)C#N Show InChI InChI=1S/C16H11N3/c1-11-5-6-13-7-8-15(19-16(13)18-11)14-4-2-3-12(9-14)10-17/h2-9H,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	480	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research & Development Curated by ChEMBL					Assay Description Antagonist activity at rat mGlu5 receptor expressed in CHO cells assessed as inhibition of quisqualate-stimulated calcium mobilization				Bioorg Med Chem Lett 17: 6525-8 (2007) Article DOI: 10.1016/j.bmcl.2007.09.083 BindingDB Entry DOI: 10.7270/Q2V40TXS
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat))	BDBM50090686 (2-Methyl-7-phenyl-[1,8]naphthyridine | 2-methyl-7-...) Show SMILES Cc1ccc2ccc(nc2n1)-c1ccccc1 Show InChI InChI=1S/C15H12N2/c1-11-7-8-13-9-10-14(17-15(13)16-11)12-5-3-2-4-6-12/h2-10H,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	664	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research & Development Curated by ChEMBL					Assay Description Antagonist activity at rat mGlu5 receptor expressed in CHO cells assessed as inhibition of quisqualate-stimulated calcium mobilization				Bioorg Med Chem Lett 17: 6525-8 (2007) Article DOI: 10.1016/j.bmcl.2007.09.083 BindingDB Entry DOI: 10.7270/Q2V40TXS
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat))	BDBM50224938 (2-methyl-7-m-tolyl-1,6-naphthyridine | CHEMBL23643...) Show SMILES Cc1cccc(c1)-c1cc2nc(C)ccc2cn1 Show InChI InChI=1S/C16H14N2/c1-11-4-3-5-13(8-11)15-9-16-14(10-17-15)7-6-12(2)18-16/h3-10H,1-2H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	676	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research & Development Curated by ChEMBL					Assay Description Antagonist activity at rat mGlu5 receptor expressed in CHO cells assessed as inhibition of quisqualate-stimulated calcium mobilization				Bioorg Med Chem Lett 17: 6525-8 (2007) Article DOI: 10.1016/j.bmcl.2007.09.083 BindingDB Entry DOI: 10.7270/Q2V40TXS
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat))	BDBM50224930 (7-m-tolyl-1,6-naphthyridine | CHEMBL238388) Show SMILES Cc1cccc(c1)-c1cc2ncccc2cn1 Show InChI InChI=1S/C15H12N2/c1-11-4-2-5-12(8-11)14-9-15-13(10-17-14)6-3-7-16-15/h2-10H,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.27E+3	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research & Development Curated by ChEMBL					Assay Description Antagonist activity at rat mGlu5 receptor expressed in CHO cells assessed as inhibition of quisqualate-stimulated calcium mobilization				Bioorg Med Chem Lett 17: 6525-8 (2007) Article DOI: 10.1016/j.bmcl.2007.09.083 BindingDB Entry DOI: 10.7270/Q2V40TXS
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat))	BDBM50220081 (2-(3-methoxyphenyl)-7-methylpyrido[2,3-d]pyrimidin...) Show SMILES COc1cccc(c1)-c1ncc2ccc(C)nc2n1 Show InChI InChI=1S/C15H13N3O/c1-10-6-7-12-9-16-14(18-15(12)17-10)11-4-3-5-13(8-11)19-2/h3-9H,1-2H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research & Development Curated by ChEMBL					Assay Description Antagonistic activity at rat mGluR5 expressed in CHO cells assessed as inhibition of quisqualate stimulated calcium mobilization by FLIPR technology				Bioorg Med Chem Lett 17: 5396-9 (2007) Article DOI: 10.1016/j.bmcl.2007.07.047 BindingDB Entry DOI: 10.7270/Q2JH3KWK
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat))	BDBM50224933 (3-fluoro-5-(1,6-naphthyridin-7-yl)benzonitrile | C...) Show SMILES Fc1cc(cc(c1)-c1cc2ncccc2cn1)C#N Show InChI InChI=1S/C15H8FN3/c16-13-5-10(8-17)4-12(6-13)15-7-14-11(9-19-15)2-1-3-18-14/h1-7,9H	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.59E+3	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research & Development Curated by ChEMBL					Assay Description Antagonist activity at rat mGlu5 receptor expressed in CHO cells assessed as inhibition of quisqualate-stimulated calcium mobilization				Bioorg Med Chem Lett 17: 6525-8 (2007) Article DOI: 10.1016/j.bmcl.2007.09.083 BindingDB Entry DOI: 10.7270/Q2V40TXS
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat))	BDBM50224918 (2-phenyl-1,8-naphthyridine | CHEMBL235396) Show SMILES c1ccc(cc1)-c1ccc2cccnc2n1 Show InChI InChI=1S/C14H10N2/c1-2-5-11(6-3-1)13-9-8-12-7-4-10-15-14(12)16-13/h1-10H	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.84E+3	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research & Development Curated by ChEMBL					Assay Description Antagonist activity at rat mGlu5 receptor expressed in CHO cells assessed as inhibition of quisqualate-stimulated calcium mobilization				Bioorg Med Chem Lett 17: 6525-8 (2007) Article DOI: 10.1016/j.bmcl.2007.09.083 BindingDB Entry DOI: 10.7270/Q2V40TXS
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat))	BDBM50220097 (7-methyl-2-phenylpyrido[2,3-d]pyrimidine | CHEMBL3...) Show SMILES Cc1ccc2cnc(nc2n1)-c1ccccc1 Show InChI InChI=1S/C14H11N3/c1-10-7-8-12-9-15-13(17-14(12)16-10)11-5-3-2-4-6-11/h2-9H,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.70E+3	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research & Development Curated by ChEMBL					Assay Description Antagonistic activity at rat mGluR5 expressed in CHO cells assessed as inhibition of quisqualate stimulated calcium mobilization by FLIPR technology				Bioorg Med Chem Lett 17: 5396-9 (2007) Article DOI: 10.1016/j.bmcl.2007.07.047 BindingDB Entry DOI: 10.7270/Q2JH3KWK
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat))	BDBM50224943 (7-(3-fluoro-5-methylphenyl)-2-methyl-1,6-naphthyri...) Show SMILES Cc1cc(F)cc(c1)-c1cc2nc(C)ccc2cn1 Show InChI InChI=1S/C16H13FN2/c1-10-5-13(7-14(17)6-10)15-8-16-12(9-18-15)4-3-11(2)19-16/h3-9H,1-2H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.93E+3	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research & Development Curated by ChEMBL					Assay Description Antagonist activity at rat mGlu5 receptor expressed in CHO cells assessed as inhibition of quisqualate-stimulated calcium mobilization				Bioorg Med Chem Lett 17: 6525-8 (2007) Article DOI: 10.1016/j.bmcl.2007.09.083 BindingDB Entry DOI: 10.7270/Q2V40TXS
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat))	BDBM50224927 (7-(3,5-dimethoxyphenyl)-1,6-naphthyridine | CHEMBL...) Show SMILES COc1cc(OC)cc(c1)-c1cc2ncccc2cn1 Show InChI InChI=1S/C16H14N2O2/c1-19-13-6-12(7-14(8-13)20-2)16-9-15-11(10-18-16)4-3-5-17-15/h3-10H,1-2H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	6.07E+3	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research & Development Curated by ChEMBL					Assay Description Antagonist activity at rat mGlu5 receptor expressed in CHO cells assessed as inhibition of quisqualate-stimulated calcium mobilization				Bioorg Med Chem Lett 17: 6525-8 (2007) Article DOI: 10.1016/j.bmcl.2007.09.083 BindingDB Entry DOI: 10.7270/Q2V40TXS
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat))	BDBM50224937 (7-(3-fluoro-5-methylphenyl)-1,6-naphthyridine | CH...) Show SMILES Cc1cc(F)cc(c1)-c1cc2ncccc2cn1 Show InChI InChI=1S/C15H11FN2/c1-10-5-12(7-13(16)6-10)15-8-14-11(9-18-15)3-2-4-17-14/h2-9H,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	6.57E+3	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research & Development Curated by ChEMBL					Assay Description Antagonist activity at rat mGlu5 receptor expressed in CHO cells assessed as inhibition of quisqualate-stimulated calcium mobilization				Bioorg Med Chem Lett 17: 6525-8 (2007) Article DOI: 10.1016/j.bmcl.2007.09.083 BindingDB Entry DOI: 10.7270/Q2V40TXS
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat))	BDBM50224944 (7-(3-methoxyphenyl)-2-methyl-1,6-naphthyridine | C...) Show SMILES COc1cccc(c1)-c1cc2nc(C)ccc2cn1 Show InChI InChI=1S/C16H14N2O/c1-11-6-7-13-10-17-15(9-16(13)18-11)12-4-3-5-14(8-12)19-2/h3-10H,1-2H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	7.90E+3	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research & Development Curated by ChEMBL					Assay Description Antagonist activity at rat mGlu5 receptor expressed in CHO cells assessed as inhibition of quisqualate-stimulated calcium mobilization				Bioorg Med Chem Lett 17: 6525-8 (2007) Article DOI: 10.1016/j.bmcl.2007.09.083 BindingDB Entry DOI: 10.7270/Q2V40TXS
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat))	BDBM50224945 (3-(3,4-dimethylphenyl)-1,5-naphthyridine | CHEMBL2...) Show SMILES Cc1ccc(cc1C)-c1cnc2cccnc2c1 Show InChI InChI=1S/C16H14N2/c1-11-5-6-13(8-12(11)2)14-9-16-15(18-10-14)4-3-7-17-16/h3-10H,1-2H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.20E+4	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research & Development Curated by ChEMBL					Assay Description Antagonist activity at rat mGlu5 receptor expressed in CHO cells assessed as inhibition of quisqualate-stimulated calcium mobilization				Bioorg Med Chem Lett 17: 6525-8 (2007) Article DOI: 10.1016/j.bmcl.2007.09.083 BindingDB Entry DOI: 10.7270/Q2V40TXS
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat))	BDBM50224919 (3-m-tolyl-1,5-naphthyridine | CHEMBL236263) Show SMILES Cc1cccc(c1)-c1cnc2cccnc2c1 Show InChI InChI=1S/C15H12N2/c1-11-4-2-5-12(8-11)13-9-15-14(17-10-13)6-3-7-16-15/h2-10H,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.57E+4	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research & Development Curated by ChEMBL					Assay Description Antagonist activity at rat mGlu5 receptor expressed in CHO cells assessed as inhibition of quisqualate-stimulated calcium mobilization				Bioorg Med Chem Lett 17: 6525-8 (2007) Article DOI: 10.1016/j.bmcl.2007.09.083 BindingDB Entry DOI: 10.7270/Q2V40TXS
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat))	BDBM50224942 (3-(1,5-naphthyridin-3-yl)benzonitrile | CHEMBL3947...) Show SMILES N#Cc1cccc(c1)-c1cnc2cccnc2c1 Show InChI InChI=1S/C15H9N3/c16-9-11-3-1-4-12(7-11)13-8-15-14(18-10-13)5-2-6-17-15/h1-8,10H	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.86E+4	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research & Development Curated by ChEMBL					Assay Description Antagonist activity at rat mGlu5 receptor expressed in CHO cells assessed as inhibition of quisqualate-stimulated calcium mobilization				Bioorg Med Chem Lett 17: 6525-8 (2007) Article DOI: 10.1016/j.bmcl.2007.09.083 BindingDB Entry DOI: 10.7270/Q2V40TXS
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat))	BDBM50220098 (3-(pyrido[2,3-d]pyrimidin-2-yl)benzonitrile | CHEM...) Show SMILES N#Cc1cccc(c1)-c1ncc2cccnc2n1 Show InChI InChI=1S/C14H8N4/c15-8-10-3-1-4-11(7-10)13-17-9-12-5-2-6-16-14(12)18-13/h1-7,9H	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>2.61E+4	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research & Development Curated by ChEMBL					Assay Description Antagonistic activity at rat mGluR5 expressed in CHO cells assessed as inhibition of quisqualate stimulated calcium mobilization by FLIPR technology				Bioorg Med Chem Lett 17: 5396-9 (2007) Article DOI: 10.1016/j.bmcl.2007.07.047 BindingDB Entry DOI: 10.7270/Q2JH3KWK
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat))	BDBM50224934 (2-methyl-7-phenyl-1,6-naphthyridine | CHEMBL236429) Show SMILES Cc1ccc2cnc(cc2n1)-c1ccccc1 Show InChI InChI=1S/C15H12N2/c1-11-7-8-13-10-16-14(9-15(13)17-11)12-5-3-2-4-6-12/h2-10H,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research & Development Curated by ChEMBL					Assay Description Antagonist activity at rat mGlu5 receptor expressed in CHO cells assessed as inhibition of quisqualate-stimulated calcium mobilization				Bioorg Med Chem Lett 17: 6525-8 (2007) Article DOI: 10.1016/j.bmcl.2007.09.083 BindingDB Entry DOI: 10.7270/Q2V40TXS
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat))	BDBM50220089 (7-methyl-2-(3-(methylsulfonyl)phenyl)pyrido[2,3-d]...) Show SMILES Cc1ccc2cnc(nc2n1)-c1cccc(c1)S(C)(=O)=O Show InChI InChI=1S/C15H13N3O2S/c1-10-6-7-12-9-16-14(18-15(12)17-10)11-4-3-5-13(8-11)21(2,19)20/h3-9H,1-2H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research & Development Curated by ChEMBL					Assay Description Antagonistic activity at rat mGluR5 expressed in CHO cells assessed as inhibition of quisqualate stimulated calcium mobilization by FLIPR technology				Bioorg Med Chem Lett 17: 5396-9 (2007) Article DOI: 10.1016/j.bmcl.2007.07.047 BindingDB Entry DOI: 10.7270/Q2JH3KWK
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat))	BDBM50220091 (2-(2,4-dichlorophenyl)-7-methylpyrido[2,3-d]pyrimi...) Show SMILES Cc1ccc2cnc(nc2n1)-c1ccc(Cl)cc1Cl Show InChI InChI=1S/C14H9Cl2N3/c1-8-2-3-9-7-17-14(19-13(9)18-8)11-5-4-10(15)6-12(11)16/h2-7H,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research & Development Curated by ChEMBL					Assay Description Antagonistic activity at rat mGluR5 expressed in CHO cells assessed as inhibition of quisqualate stimulated calcium mobilization by FLIPR technology				Bioorg Med Chem Lett 17: 5396-9 (2007) Article DOI: 10.1016/j.bmcl.2007.07.047 BindingDB Entry DOI: 10.7270/Q2JH3KWK
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat))	BDBM50220095 (2-(2-methoxyphenyl)-7-methylpyrido[2,3-d]pyrimidin...) Show SMILES COc1ccccc1-c1ncc2ccc(C)nc2n1 Show InChI InChI=1S/C15H13N3O/c1-10-7-8-11-9-16-15(18-14(11)17-10)12-5-3-4-6-13(12)19-2/h3-9H,1-2H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research & Development Curated by ChEMBL					Assay Description Antagonistic activity at rat mGluR5 expressed in CHO cells assessed as inhibition of quisqualate stimulated calcium mobilization by FLIPR technology				Bioorg Med Chem Lett 17: 5396-9 (2007) Article DOI: 10.1016/j.bmcl.2007.07.047 BindingDB Entry DOI: 10.7270/Q2JH3KWK
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat))	BDBM50220090 (2-(3,4-dichlorophenyl)-7-methylpyrido[2,3-d]pyrimi...) Show SMILES Cc1ccc2cnc(nc2n1)-c1ccc(Cl)c(Cl)c1 Show InChI InChI=1S/C14H9Cl2N3/c1-8-2-3-10-7-17-13(19-14(10)18-8)9-4-5-11(15)12(16)6-9/h2-7H,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research & Development Curated by ChEMBL					Assay Description Antagonistic activity at rat mGluR5 expressed in CHO cells assessed as inhibition of quisqualate stimulated calcium mobilization by FLIPR technology				Bioorg Med Chem Lett 17: 5396-9 (2007) Article DOI: 10.1016/j.bmcl.2007.07.047 BindingDB Entry DOI: 10.7270/Q2JH3KWK
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat))	BDBM50220093 (2-(4-bromophenyl)-7-methylpyrido[2,3-d]pyrimidine ...) Show SMILES Cc1ccc2cnc(nc2n1)-c1ccc(Br)cc1 Show InChI InChI=1S/C14H10BrN3/c1-9-2-3-11-8-16-13(18-14(11)17-9)10-4-6-12(15)7-5-10/h2-8H,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research & Development Curated by ChEMBL					Assay Description Antagonistic activity at rat mGluR5 expressed in CHO cells assessed as inhibition of quisqualate stimulated calcium mobilization by FLIPR technology				Bioorg Med Chem Lett 17: 5396-9 (2007) Article DOI: 10.1016/j.bmcl.2007.07.047 BindingDB Entry DOI: 10.7270/Q2JH3KWK
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat))	BDBM50220092 (CHEMBL238554 | methyl 4-(7-methylpyrido[2,3-d]pyri...) Show SMILES COC(=O)c1ccc(cc1)-c1ncc2ccc(C)nc2n1 Show InChI InChI=1S/C16H13N3O2/c1-10-3-4-13-9-17-14(19-15(13)18-10)11-5-7-12(8-6-11)16(20)21-2/h3-9H,1-2H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research & Development Curated by ChEMBL					Assay Description Antagonistic activity at rat mGluR5 expressed in CHO cells assessed as inhibition of quisqualate stimulated calcium mobilization by FLIPR technology				Bioorg Med Chem Lett 17: 5396-9 (2007) Article DOI: 10.1016/j.bmcl.2007.07.047 BindingDB Entry DOI: 10.7270/Q2JH3KWK
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat))	BDBM50220080 ((3-(7-methylpyrido[2,3-d]pyrimidin-2-yl)phenyl)met...) Show SMILES Cc1ccc2cnc(nc2n1)-c1cccc(CN)c1 Show InChI InChI=1S/C15H14N4/c1-10-5-6-13-9-17-14(19-15(13)18-10)12-4-2-3-11(7-12)8-16/h2-7,9H,8,16H2,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research & Development Curated by ChEMBL					Assay Description Antagonistic activity at rat mGluR5 expressed in CHO cells assessed as inhibition of quisqualate stimulated calcium mobilization by FLIPR technology				Bioorg Med Chem Lett 17: 5396-9 (2007) Article DOI: 10.1016/j.bmcl.2007.07.047 BindingDB Entry DOI: 10.7270/Q2JH3KWK
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat))	BDBM50220078 (7-methyl-2-(3,4,5-trimethoxyphenyl)pyrido[2,3-d]py...) Show SMILES COc1cc(cc(OC)c1OC)-c1ncc2ccc(C)nc2n1 Show InChI InChI=1S/C17H17N3O3/c1-10-5-6-11-9-18-16(20-17(11)19-10)12-7-13(21-2)15(23-4)14(8-12)22-3/h5-9H,1-4H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research & Development Curated by ChEMBL					Assay Description Antagonistic activity at rat mGluR5 expressed in CHO cells assessed as inhibition of quisqualate stimulated calcium mobilization by FLIPR technology				Bioorg Med Chem Lett 17: 5396-9 (2007) Article DOI: 10.1016/j.bmcl.2007.07.047 BindingDB Entry DOI: 10.7270/Q2JH3KWK
					More data for this Ligand-Target Pair

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