Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Androgen receptor (Homo sapiens (Human)) | BDBM50220643 (6-((cyclopropylmethyl)(propyl)amino)-4-(trifluorom...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 0.800 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development Curated by ChEMBL | Assay Description Displacement of [3H]dihydrotestosterone from human androgen receptor expressed in Sf9 cells | Bioorg Med Chem Lett 17: 5693-7 (2007) Article DOI: 10.1016/j.bmcl.2007.07.059 BindingDB Entry DOI: 10.7270/Q2GH9HPQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Androgen receptor (Homo sapiens (Human)) | BDBM50220635 (6-(butyl(methyl)amino)-4-(trifluoromethyl)nicotino...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 3.80 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development Curated by ChEMBL | Assay Description Displacement of [3H]dihydrotestosterone from human androgen receptor expressed in Sf9 cells | Bioorg Med Chem Lett 17: 5693-7 (2007) Article DOI: 10.1016/j.bmcl.2007.07.059 BindingDB Entry DOI: 10.7270/Q2GH9HPQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Androgen receptor (Homo sapiens (Human)) | BDBM50220642 (6-(sec-butyl(methyl)amino)-4-(trifluoromethyl)nico...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 7 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development Curated by ChEMBL | Assay Description Displacement of [3H]dihydrotestosterone from human androgen receptor expressed in Sf9 cells | Bioorg Med Chem Lett 17: 5693-7 (2007) Article DOI: 10.1016/j.bmcl.2007.07.059 BindingDB Entry DOI: 10.7270/Q2GH9HPQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Androgen receptor (Homo sapiens (Human)) | BDBM25437 ((trifluoromethyl)benzonitrile, 14 | 4-{[(1R,2S)-2-...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 12 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development Curated by ChEMBL | Assay Description Antagonist activity at androgen receptor expressed in MDA-MB-453 cells assessed as inhibition of dihydrotestosterone-induced response in reporter gen... | Bioorg Med Chem Lett 17: 5983-8 (2007) Article DOI: 10.1016/j.bmcl.2007.07.075 BindingDB Entry DOI: 10.7270/Q27W6BWT | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Androgen receptor (Homo sapiens (Human)) | BDBM50221436 (4-(2-cyano-cyclohexyl-oxy)-2-trifluoromethyl-benzo...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 13 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development Curated by ChEMBL | Assay Description Antagonist activity at androgen receptor expressed in MDA-MB-453 cells assessed as inhibition of dihydrotestosterone-induced response in reporter gen... | Bioorg Med Chem Lett 17: 5983-8 (2007) Article DOI: 10.1016/j.bmcl.2007.07.075 BindingDB Entry DOI: 10.7270/Q27W6BWT | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Androgen receptor (Homo sapiens (Human)) | BDBM25428 (4-[3-(4-hydroxybutyl)-4,4-dimethyl-2,5-dioxoimidaz...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 15.9 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development Curated by ChEMBL | Assay Description Displacement of [3H]dihydrotestosterone from human androgen receptor expressed in Sf9 cells | Bioorg Med Chem Lett 17: 5693-7 (2007) Article DOI: 10.1016/j.bmcl.2007.07.059 BindingDB Entry DOI: 10.7270/Q2GH9HPQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Androgen receptor (Homo sapiens (Human)) | BDBM25428 (4-[3-(4-hydroxybutyl)-4,4-dimethyl-2,5-dioxoimidaz...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 16 | n/a | n/a | n/a | n/a | 7.4 | 4 |
Pfizer | Assay Description The competitive radio-ligand binding analysis was performed on human AR extracts from transfected Sf9 cells in the presence or absence of differing c... | J Med Chem 51: 7010-4 (2008) Article DOI: 10.1021/jm8009316 BindingDB Entry DOI: 10.7270/Q2Z31WZ1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Androgen receptor (Homo sapiens (Human)) | BDBM25432 (6-{methyl[(1R)-1-phenylethyl]amino}-4-(trifluorome...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 20 | n/a | n/a | n/a | n/a | 7.4 | 4 |
Pfizer | Assay Description The competitive radio-ligand binding analysis was performed on human AR extracts from transfected Sf9 cells in the presence or absence of differing c... | J Med Chem 51: 7010-4 (2008) Article DOI: 10.1021/jm8009316 BindingDB Entry DOI: 10.7270/Q2Z31WZ1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Androgen receptor (Homo sapiens (Human)) | BDBM25432 (6-{methyl[(1R)-1-phenylethyl]amino}-4-(trifluorome...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development Curated by ChEMBL | Assay Description Displacement of [3H]dihydrotestosterone from human androgen receptor expressed in Sf9 cells | Bioorg Med Chem Lett 17: 5693-7 (2007) Article DOI: 10.1016/j.bmcl.2007.07.059 BindingDB Entry DOI: 10.7270/Q2GH9HPQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Androgen receptor (Homo sapiens (Human)) | BDBM25434 (4-(2-hydroxycyclohexyl)-2-(trifluoromethyl)benzoni...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 26 | n/a | n/a | n/a | n/a | 7.4 | 4 |
Pfizer | Assay Description The competitive radio-ligand binding analysis was performed on human AR extracts from transfected Sf9 cells in the presence or absence of differing c... | J Med Chem 51: 7010-4 (2008) Article DOI: 10.1021/jm8009316 BindingDB Entry DOI: 10.7270/Q2Z31WZ1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Androgen receptor (Homo sapiens (Human)) | BDBM50319612 ((R)-(+)-4-[4,4-Dimethyl-1-(4-methylsulfanyl-benzyl...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 28 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research& Development Curated by ChEMBL | Assay Description Antagonist activity at androgen receptor in human MDA-MB-453 cells coexpressing MMTV-ARE reporter gene assessed as inhibition of DHT-induced response | J Med Chem 53: 4422-7 (2010) Article DOI: 10.1021/jm9018004 BindingDB Entry DOI: 10.7270/Q2DV1K1T | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Androgen receptor (Homo sapiens (Human)) | BDBM25428 (4-[3-(4-hydroxybutyl)-4,4-dimethyl-2,5-dioxoimidaz...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 31.1 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development Curated by ChEMBL | Assay Description Antagonist activity at human androgen receptor expressed in MDA-MB-453 cells | Bioorg Med Chem Lett 17: 5693-7 (2007) Article DOI: 10.1016/j.bmcl.2007.07.059 BindingDB Entry DOI: 10.7270/Q2GH9HPQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Androgen receptor (Homo sapiens (Human)) | BDBM25431 (4-(2-hydroxyphenyl)-2-methoxybenzonitrile | diaryl...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 37 | n/a | n/a | n/a | n/a | 7.4 | 4 |
Pfizer | Assay Description The competitive radio-ligand binding analysis was performed on human AR extracts from transfected Sf9 cells in the presence or absence of differing c... | J Med Chem 51: 7010-4 (2008) Article DOI: 10.1021/jm8009316 BindingDB Entry DOI: 10.7270/Q2Z31WZ1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Androgen receptor (Homo sapiens (Human)) | BDBM25436 (4-[(1R,2R)-2-hydroxycyclohexyl]-2-(trifluoromethyl...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 37 | n/a | n/a | n/a | n/a | 7.4 | 4 |
Pfizer | Assay Description The competitive radio-ligand binding analysis was performed on human AR extracts from transfected Sf9 cells in the presence or absence of differing c... | J Med Chem 51: 7010-4 (2008) Article DOI: 10.1021/jm8009316 BindingDB Entry DOI: 10.7270/Q2Z31WZ1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Androgen receptor (Homo sapiens (Human)) | BDBM50319611 ((R)-4-(1-benzyl-4,4-dimethyl-2-oxopyrrolidin-3-ylo...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 38 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research& Development Curated by ChEMBL | Assay Description Antagonist activity at androgen receptor in human MDA-MB-453 cells coexpressing MMTV-ARE reporter gene assessed as inhibition of DHT-induced response | J Med Chem 53: 4422-7 (2010) Article DOI: 10.1021/jm9018004 BindingDB Entry DOI: 10.7270/Q2DV1K1T | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Androgen receptor (Homo sapiens (Human)) | BDBM25430 (4-(2-hydroxyphenyl)-2-(trifluoromethyl)benzonitril...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 39.9 | n/a | n/a | n/a | n/a | 7.4 | 4 |
Pfizer | Assay Description The competitive radio-ligand binding analysis was performed on human AR extracts from transfected Sf9 cells in the presence or absence of differing c... | J Med Chem 51: 7010-4 (2008) Article DOI: 10.1021/jm8009316 BindingDB Entry DOI: 10.7270/Q2Z31WZ1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Androgen receptor (Homo sapiens (Human)) | BDBM50221435 (4-((trans)-2-cyanocyclohexyloxy)-2-(trifluoromethy...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 43 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development Curated by ChEMBL | Assay Description Displacement of [3H]DHT from androgen receptor expressed in Sf9 cells | Bioorg Med Chem Lett 17: 5983-8 (2007) Article DOI: 10.1016/j.bmcl.2007.07.075 BindingDB Entry DOI: 10.7270/Q27W6BWT | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Androgen receptor (Homo sapiens (Human)) | BDBM50319613 ((R)-(+)-4-(1-(2-Fluorobenzyl)-4,4-dimethyl-2-oxopy...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 44 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research& Development Curated by ChEMBL | Assay Description Antagonist activity at androgen receptor in human MDA-MB-453 cells coexpressing MMTV-ARE reporter gene assessed as inhibition of DHT-induced response | J Med Chem 53: 4422-7 (2010) Article DOI: 10.1021/jm9018004 BindingDB Entry DOI: 10.7270/Q2DV1K1T | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Androgen receptor (Homo sapiens (Human)) | BDBM25432 (6-{methyl[(1R)-1-phenylethyl]amino}-4-(trifluorome...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 45 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development Curated by ChEMBL | Assay Description Antagonist activity at human androgen receptor expressed in MDA-MB-453 cells | Bioorg Med Chem Lett 17: 5693-7 (2007) Article DOI: 10.1016/j.bmcl.2007.07.059 BindingDB Entry DOI: 10.7270/Q2GH9HPQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Androgen receptor (Homo sapiens (Human)) | BDBM50248594 (4-(2-Fluorophenylthio)-2-(trifluoromethyl)benzonit...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | Article PubMed | n/a | n/a | 54 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research& Development Curated by ChEMBL | Assay Description Antagonist activity at androgen receptor in human MDA-MB-453 cells coexpressing MMTV-ARE reporter gene assessed as inhibition of DHT-induced response | J Med Chem 53: 4422-7 (2010) Article DOI: 10.1021/jm9018004 BindingDB Entry DOI: 10.7270/Q2DV1K1T | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Androgen receptor (Homo sapiens (Human)) | BDBM50221436 (4-(2-cyano-cyclohexyl-oxy)-2-trifluoromethyl-benzo...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 58 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development Curated by ChEMBL | Assay Description Displacement of [3H]DHT from androgen receptor expressed in Sf9 cells | Bioorg Med Chem Lett 17: 5983-8 (2007) Article DOI: 10.1016/j.bmcl.2007.07.075 BindingDB Entry DOI: 10.7270/Q27W6BWT | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Androgen receptor (Homo sapiens (Human)) | BDBM25437 ((trifluoromethyl)benzonitrile, 14 | 4-{[(1R,2S)-2-...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 60 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development Curated by ChEMBL | Assay Description Displacement of [3H]DHT from androgen receptor expressed in Sf9 cells | Bioorg Med Chem Lett 17: 5983-8 (2007) Article DOI: 10.1016/j.bmcl.2007.07.075 BindingDB Entry DOI: 10.7270/Q27W6BWT | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Androgen receptor (Homo sapiens (Human)) | BDBM25437 ((trifluoromethyl)benzonitrile, 14 | 4-{[(1R,2S)-2-...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 60 | n/a | n/a | n/a | n/a | 7.4 | 4 |
Pfizer | Assay Description The competitive radio-ligand binding analysis was performed on human AR extracts from transfected Sf9 cells in the presence or absence of differing c... | J Med Chem 51: 7010-4 (2008) Article DOI: 10.1021/jm8009316 BindingDB Entry DOI: 10.7270/Q2Z31WZ1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Androgen receptor (Homo sapiens (Human)) | BDBM50319614 (4-(2,4-Difluorophenoxy)-2-(trifluoromethyl)benzoni...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 60 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research& Development Curated by ChEMBL | Assay Description Antagonist activity at androgen receptor in human MDA-MB-453 cells coexpressing MMTV-ARE reporter gene assessed as inhibition of DHT-induced response | J Med Chem 53: 4422-7 (2010) Article DOI: 10.1021/jm9018004 BindingDB Entry DOI: 10.7270/Q2DV1K1T | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Androgen receptor (Homo sapiens (Human)) | BDBM50220640 (6-(4-methylpiperidin-1-yl)-4-(trifluoromethyl)nico...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 73 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development Curated by ChEMBL | Assay Description Displacement of [3H]dihydrotestosterone from human androgen receptor expressed in Sf9 cells | Bioorg Med Chem Lett 17: 5693-7 (2007) Article DOI: 10.1016/j.bmcl.2007.07.059 BindingDB Entry DOI: 10.7270/Q2GH9HPQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Androgen receptor (Homo sapiens (Human)) | BDBM50220644 (6-(dipropylamino)-4-(trifluoromethyl)nicotinonitri...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 78 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development Curated by ChEMBL | Assay Description Displacement of [3H]dihydrotestosterone from human androgen receptor expressed in Sf9 cells | Bioorg Med Chem Lett 17: 5693-7 (2007) Article DOI: 10.1016/j.bmcl.2007.07.059 BindingDB Entry DOI: 10.7270/Q2GH9HPQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Androgen receptor (Homo sapiens (Human)) | BDBM50319611 ((R)-4-(1-benzyl-4,4-dimethyl-2-oxopyrrolidin-3-ylo...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 100 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research& Development Curated by ChEMBL | Assay Description Displacement of [3H]DHT from human AR expressed in baculovirus Sf9 cells system by scintillation counting | J Med Chem 53: 4422-7 (2010) Article DOI: 10.1021/jm9018004 BindingDB Entry DOI: 10.7270/Q2DV1K1T | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Androgen receptor (Homo sapiens (Human)) | BDBM50220639 (6-(methyl(1-phenylethyl)amino)-4-(trifluoromethyl)...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 123 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development Curated by ChEMBL | Assay Description Displacement of [3H]dihydrotestosterone from human androgen receptor expressed in Sf9 cells | Bioorg Med Chem Lett 17: 5693-7 (2007) Article DOI: 10.1016/j.bmcl.2007.07.059 BindingDB Entry DOI: 10.7270/Q2GH9HPQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Androgen receptor (Homo sapiens (Human)) | BDBM50220640 (6-(4-methylpiperidin-1-yl)-4-(trifluoromethyl)nico...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 136 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development Curated by ChEMBL | Assay Description Antagonist activity at human androgen receptor expressed in MDA-MB-453 cells | Bioorg Med Chem Lett 17: 5693-7 (2007) Article DOI: 10.1016/j.bmcl.2007.07.059 BindingDB Entry DOI: 10.7270/Q2GH9HPQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Androgen receptor (Homo sapiens (Human)) | BDBM50220638 (6-(octahydroisoquinolin-2(1H)-yl)-4-(trifluorometh...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 169 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development Curated by ChEMBL | Assay Description Displacement of [3H]dihydrotestosterone from human androgen receptor expressed in Sf9 cells | Bioorg Med Chem Lett 17: 5693-7 (2007) Article DOI: 10.1016/j.bmcl.2007.07.059 BindingDB Entry DOI: 10.7270/Q2GH9HPQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Androgen receptor (Homo sapiens (Human)) | BDBM50319613 ((R)-(+)-4-(1-(2-Fluorobenzyl)-4,4-dimethyl-2-oxopy...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 174 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research& Development Curated by ChEMBL | Assay Description Displacement of [3H]DHT from human AR expressed in baculovirus Sf9 cells system by scintillation counting | J Med Chem 53: 4422-7 (2010) Article DOI: 10.1021/jm9018004 BindingDB Entry DOI: 10.7270/Q2DV1K1T | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Androgen receptor (Homo sapiens (Human)) | BDBM50248594 (4-(2-Fluorophenylthio)-2-(trifluoromethyl)benzonit...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | Article PubMed | n/a | n/a | 184 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research& Development Curated by ChEMBL | Assay Description Displacement of [3H]DHT from human AR expressed in baculovirus Sf9 cells system by scintillation counting | J Med Chem 53: 4422-7 (2010) Article DOI: 10.1021/jm9018004 BindingDB Entry DOI: 10.7270/Q2DV1K1T | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Androgen receptor (Homo sapiens (Human)) | BDBM50221435 (4-((trans)-2-cyanocyclohexyloxy)-2-(trifluoromethy...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 196 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development Curated by ChEMBL | Assay Description Antagonist activity at androgen receptor expressed in MDA-MB-453 cells assessed as inhibition of dihydrotestosterone-induced response in reporter gen... | Bioorg Med Chem Lett 17: 5983-8 (2007) Article DOI: 10.1016/j.bmcl.2007.07.075 BindingDB Entry DOI: 10.7270/Q27W6BWT | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Androgen receptor (Homo sapiens (Human)) | BDBM50220641 (6-(piperidin-1-yl)-4-(trifluoromethyl)nicotinonitr...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 209 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development Curated by ChEMBL | Assay Description Displacement of [3H]dihydrotestosterone from human androgen receptor expressed in Sf9 cells | Bioorg Med Chem Lett 17: 5693-7 (2007) Article DOI: 10.1016/j.bmcl.2007.07.059 BindingDB Entry DOI: 10.7270/Q2GH9HPQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Androgen receptor (Homo sapiens (Human)) | BDBM50220639 (6-(methyl(1-phenylethyl)amino)-4-(trifluoromethyl)...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 229 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development Curated by ChEMBL | Assay Description Antagonist activity at human androgen receptor expressed in MDA-MB-453 cells | Bioorg Med Chem Lett 17: 5693-7 (2007) Article DOI: 10.1016/j.bmcl.2007.07.059 BindingDB Entry DOI: 10.7270/Q2GH9HPQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Androgen receptor (Homo sapiens (Human)) | BDBM50220638 (6-(octahydroisoquinolin-2(1H)-yl)-4-(trifluorometh...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 260 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development Curated by ChEMBL | Assay Description Antagonist activity at human androgen receptor expressed in MDA-MB-453 cells | Bioorg Med Chem Lett 17: 5693-7 (2007) Article DOI: 10.1016/j.bmcl.2007.07.059 BindingDB Entry DOI: 10.7270/Q2GH9HPQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Androgen receptor (Homo sapiens (Human)) | BDBM50319612 ((R)-(+)-4-[4,4-Dimethyl-1-(4-methylsulfanyl-benzyl...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 316 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research& Development Curated by ChEMBL | Assay Description Displacement of [3H]DHT from human AR expressed in baculovirus Sf9 cells system by scintillation counting | J Med Chem 53: 4422-7 (2010) Article DOI: 10.1021/jm9018004 BindingDB Entry DOI: 10.7270/Q2DV1K1T | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Androgen receptor (Homo sapiens (Human)) | BDBM50220641 (6-(piperidin-1-yl)-4-(trifluoromethyl)nicotinonitr...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 422 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development Curated by ChEMBL | Assay Description Antagonist activity at human androgen receptor expressed in MDA-MB-453 cells | Bioorg Med Chem Lett 17: 5693-7 (2007) Article DOI: 10.1016/j.bmcl.2007.07.059 BindingDB Entry DOI: 10.7270/Q2GH9HPQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Androgen receptor (Homo sapiens (Human)) | BDBM50319614 (4-(2,4-Difluorophenoxy)-2-(trifluoromethyl)benzoni...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 488 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research& Development Curated by ChEMBL | Assay Description Displacement of [3H]DHT from human AR expressed in baculovirus Sf9 cells system by scintillation counting | J Med Chem 53: 4422-7 (2010) Article DOI: 10.1021/jm9018004 BindingDB Entry DOI: 10.7270/Q2DV1K1T | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Androgen receptor (Homo sapiens (Human)) | BDBM50220643 (6-((cyclopropylmethyl)(propyl)amino)-4-(trifluorom...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | >1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development Curated by ChEMBL | Assay Description Antagonist activity at human androgen receptor expressed in MDA-MB-453 cells | Bioorg Med Chem Lett 17: 5693-7 (2007) Article DOI: 10.1016/j.bmcl.2007.07.059 BindingDB Entry DOI: 10.7270/Q2GH9HPQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Androgen receptor (Homo sapiens (Human)) | BDBM50220642 (6-(sec-butyl(methyl)amino)-4-(trifluoromethyl)nico...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | >1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development Curated by ChEMBL | Assay Description Antagonist activity at human androgen receptor expressed in MDA-MB-453 cells | Bioorg Med Chem Lett 17: 5693-7 (2007) Article DOI: 10.1016/j.bmcl.2007.07.059 BindingDB Entry DOI: 10.7270/Q2GH9HPQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Androgen receptor (Homo sapiens (Human)) | BDBM50220635 (6-(butyl(methyl)amino)-4-(trifluoromethyl)nicotino...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | >1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development Curated by ChEMBL | Assay Description Antagonist activity at human androgen receptor expressed in MDA-MB-453 cells | Bioorg Med Chem Lett 17: 5693-7 (2007) Article DOI: 10.1016/j.bmcl.2007.07.059 BindingDB Entry DOI: 10.7270/Q2GH9HPQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Androgen receptor (Homo sapiens (Human)) | BDBM50220644 (6-(dipropylamino)-4-(trifluoromethyl)nicotinonitri...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | >1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development Curated by ChEMBL | Assay Description Antagonist activity at human androgen receptor expressed in MDA-MB-453 cells | Bioorg Med Chem Lett 17: 5693-7 (2007) Article DOI: 10.1016/j.bmcl.2007.07.059 BindingDB Entry DOI: 10.7270/Q2GH9HPQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Androgen receptor (Homo sapiens (Human)) | BDBM25435 (4-[(1S,2S)-2-hydroxycyclohexyl]-2-(trifluoromethyl...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.60E+3 | n/a | n/a | n/a | n/a | 7.4 | 4 |
Pfizer | Assay Description The competitive radio-ligand binding analysis was performed on human AR extracts from transfected Sf9 cells in the presence or absence of differing c... | J Med Chem 51: 7010-4 (2008) Article DOI: 10.1021/jm8009316 BindingDB Entry DOI: 10.7270/Q2Z31WZ1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Androgen receptor (Homo sapiens (Human)) | BDBM50220637 ((S)-6-(methyl(1-phenylethyl)amino)-4-(trifluoromet...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development Curated by ChEMBL | Assay Description Displacement of [3H]dihydrotestosterone from human androgen receptor expressed in Sf9 cells | Bioorg Med Chem Lett 17: 5693-7 (2007) Article DOI: 10.1016/j.bmcl.2007.07.059 BindingDB Entry DOI: 10.7270/Q2GH9HPQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Androgen receptor (Homo sapiens (Human)) | BDBM25433 (4-[(1R,2S)-2-hydroxycyclohexyl]-2-(trifluoromethyl...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | >3.00E+3 | n/a | n/a | n/a | n/a | 7.4 | 4 |
Pfizer | Assay Description The competitive radio-ligand binding analysis was performed on human AR extracts from transfected Sf9 cells in the presence or absence of differing c... | J Med Chem 51: 7010-4 (2008) Article DOI: 10.1021/jm8009316 BindingDB Entry DOI: 10.7270/Q2Z31WZ1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Progesterone receptor (Homo sapiens (Human)) | BDBM50319611 ((R)-4-(1-benzyl-4,4-dimethyl-2-oxopyrrolidin-3-ylo...) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 4.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research& Development Curated by ChEMBL | Assay Description Binding affinity to progesterone receptor by PRB assay | J Med Chem 53: 4422-7 (2010) Article DOI: 10.1021/jm9018004 BindingDB Entry DOI: 10.7270/Q2DV1K1T | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Progesterone receptor (Homo sapiens (Human)) | BDBM50319613 ((R)-(+)-4-(1-(2-Fluorobenzyl)-4,4-dimethyl-2-oxopy...) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 4.82E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research& Development Curated by ChEMBL | Assay Description Binding affinity to progesterone receptor by PRB assay | J Med Chem 53: 4422-7 (2010) Article DOI: 10.1021/jm9018004 BindingDB Entry DOI: 10.7270/Q2DV1K1T | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Androgen receptor (Homo sapiens (Human)) | BDBM50220636 ((R)-6-(1-phenylethylamino)-4-(trifluoromethyl)nico...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 4.93E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development Curated by ChEMBL | Assay Description Displacement of [3H]dihydrotestosterone from human androgen receptor expressed in Sf9 cells | Bioorg Med Chem Lett 17: 5693-7 (2007) Article DOI: 10.1016/j.bmcl.2007.07.059 BindingDB Entry DOI: 10.7270/Q2GH9HPQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Progesterone receptor (Homo sapiens (Human)) | BDBM50248594 (4-(2-Fluorophenylthio)-2-(trifluoromethyl)benzonit...) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | Article PubMed | n/a | n/a | 6.95E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research& Development Curated by ChEMBL | Assay Description Binding affinity to progesterone receptor by PRB assay | J Med Chem 53: 4422-7 (2010) Article DOI: 10.1021/jm9018004 BindingDB Entry DOI: 10.7270/Q2DV1K1T | |||||||||||
More data for this Ligand-Target Pair |
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