Found 134 hits with Last Name = 'savic' and Initial = 'v' Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Ribosomal protein S6 kinase beta-1
(Homo sapiens (Human)) | BDBM50310456
![PNG](/data/jpeg/tenK5031/BindingDB_50310456.png) (4-(1-cyclobutyl-1H-benzo[d]imidazol-2-yl)-1,2,5-ox...)Show InChI InChI=1S/C13H13N5O/c14-12-11(16-19-17-12)13-15-9-6-1-2-7-10(9)18(13)8-4-3-5-8/h1-2,6-8H,3-5H2,(H2,14,17) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
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Similars
| Article PubMed
| 4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Vertex Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description Inhibition of p70S6K assessed as decrease in NADH absorbance at 340 nm in the presence of |
Bioorg Med Chem Lett 19: 5191-4 (2009)
Article DOI: 10.1016/j.bmcl.2009.07.022 BindingDB Entry DOI: 10.7270/Q2KP8287 |
More data for this Ligand-Target Pair | |
Ribosomal protein S6 kinase beta-1
(Homo sapiens (Human)) | BDBM50310459
![PNG](/data/jpeg/tenK5031/BindingDB_50310459.png) (4-(1-(cyclopropylmethyl)-1H-benzo[d]imidazol-2-yl)...)Show InChI InChI=1S/C13H13N5O/c14-12-11(16-19-17-12)13-15-9-3-1-2-4-10(9)18(13)7-8-5-6-8/h1-4,8H,5-7H2,(H2,14,17) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
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| 12 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Vertex Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description Inhibition of p70S6K assessed as decrease in NADH absorbance at 340 nm in the presence of |
Bioorg Med Chem Lett 19: 5191-4 (2009)
Article DOI: 10.1016/j.bmcl.2009.07.022 BindingDB Entry DOI: 10.7270/Q2KP8287 |
More data for this Ligand-Target Pair | |
Ribosomal protein S6 kinase beta-1
(Homo sapiens (Human)) | BDBM50310458
![PNG](/data/jpeg/tenK5031/BindingDB_50310458.png) (4-(1-cyclohexyl-1H-benzo[d]imidazol-2-yl)-1,2,5-ox...)Show InChI InChI=1S/C15H17N5O/c16-14-13(18-21-19-14)15-17-11-8-4-5-9-12(11)20(15)10-6-2-1-3-7-10/h4-5,8-10H,1-3,6-7H2,(H2,16,19) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
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| Article PubMed
| 12 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Vertex Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description Inhibition of p70S6K assessed as decrease in NADH absorbance at 340 nm in the presence of |
Bioorg Med Chem Lett 19: 5191-4 (2009)
Article DOI: 10.1016/j.bmcl.2009.07.022 BindingDB Entry DOI: 10.7270/Q2KP8287 |
More data for this Ligand-Target Pair | |
Ribosomal protein S6 kinase beta-1
(Homo sapiens (Human)) | BDBM50310457
![PNG](/data/jpeg/tenK5031/BindingDB_50310457.png) (4-(1-cyclopentyl-1H-benzo[d]imidazol-2-yl)-1,2,5-o...)Show InChI InChI=1S/C14H15N5O/c15-13-12(17-20-18-13)14-16-10-7-3-4-8-11(10)19(14)9-5-1-2-6-9/h3-4,7-9H,1-2,5-6H2,(H2,15,18) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
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| Article PubMed
| 13 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Vertex Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description Inhibition of p70S6K assessed as decrease in NADH absorbance at 340 nm in the presence of |
Bioorg Med Chem Lett 19: 5191-4 (2009)
Article DOI: 10.1016/j.bmcl.2009.07.022 BindingDB Entry DOI: 10.7270/Q2KP8287 |
More data for this Ligand-Target Pair | |
Ribosomal protein S6 kinase beta-1
(Homo sapiens (Human)) | BDBM50310475
![PNG](/data/jpeg/tenK5031/BindingDB_50310475.png) ((2-(4-amino-1,2,5-oxadiazol-3-yl)-1-cyclobutyl-1H-...)Show InChI InChI=1S/C14H15N5O2/c15-13-12(17-21-18-13)14-16-10-6-8(7-20)4-5-11(10)19(14)9-2-1-3-9/h4-6,9,20H,1-3,7H2,(H2,15,18) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 16 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Vertex Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description Inhibition of p70S6K assessed as decrease in NADH absorbance at 340 nm in the presence of |
Bioorg Med Chem Lett 19: 5191-4 (2009)
Article DOI: 10.1016/j.bmcl.2009.07.022 BindingDB Entry DOI: 10.7270/Q2KP8287 |
More data for this Ligand-Target Pair | |
Ribosomal protein S6 kinase beta-1
(Homo sapiens (Human)) | BDBM50310474
![PNG](/data/jpeg/tenK5031/BindingDB_50310474.png) (4-(1-cyclobutyl-5-methyl-1H-benzo[d]imidazol-2-yl)...)Show InChI InChI=1S/C14H15N5O/c1-8-5-6-11-10(7-8)16-14(12-13(15)18-20-17-12)19(11)9-3-2-4-9/h5-7,9H,2-4H2,1H3,(H2,15,18) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
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Similars
| Article PubMed
| 19 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Vertex Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description Inhibition of p70S6K assessed as decrease in NADH absorbance at 340 nm in the presence of |
Bioorg Med Chem Lett 19: 5191-4 (2009)
Article DOI: 10.1016/j.bmcl.2009.07.022 BindingDB Entry DOI: 10.7270/Q2KP8287 |
More data for this Ligand-Target Pair | |
Ribosomal protein S6 kinase beta-1
(Homo sapiens (Human)) | BDBM50310461
![PNG](/data/jpeg/tenK5031/BindingDB_50310461.png) (4-(1-isobutyl-1H-benzo[d]imidazol-2-yl)-1,2,5-oxad...)Show InChI InChI=1S/C13H15N5O/c1-8(2)7-18-10-6-4-3-5-9(10)15-13(18)11-12(14)17-19-16-11/h3-6,8H,7H2,1-2H3,(H2,14,17) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
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| 22 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Vertex Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description Inhibition of p70S6K assessed as decrease in NADH absorbance at 340 nm in the presence of |
Bioorg Med Chem Lett 19: 5191-4 (2009)
Article DOI: 10.1016/j.bmcl.2009.07.022 BindingDB Entry DOI: 10.7270/Q2KP8287 |
More data for this Ligand-Target Pair | |
Advanced glycosylation end product-specific receptor
(Homo sapiens (Human)) | BDBM50249567
![PNG](/data/jpeg/tenK5024/BindingDB_50249567.png) (CHEMBL4075936)Show InChI InChI=1S/C20H22ClNO/c21-18-13-11-17(12-14-18)20(23)22(19-9-5-2-6-10-19)15-16-7-3-1-4-8-16/h1,3-4,7-8,11-14,19H,2,5-6,9-10,15H2 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
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| Article PubMed
| 25 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
King's College London
Curated by ChEMBL
| Assay Description Displacement of [I125]amyloid beta (1 to 40) from human RAGE domain V expressed in CHO cells |
J Med Chem 60: 7213-7232 (2017)
Article DOI: 10.1021/acs.jmedchem.7b00058 BindingDB Entry DOI: 10.7270/Q2KD21BP |
More data for this Ligand-Target Pair | |
Ribosomal protein S6 kinase beta-1
(Homo sapiens (Human)) | BDBM50310463
![PNG](/data/jpeg/tenK5031/BindingDB_50310463.png) (2-(2-(4-amino-1,2,5-oxadiazol-3-yl)-1H-benzo[d]imi...)Show SMILES Nc1nonc1-c1nc2ccccc2n1-c1ccccc1C#N |(29.45,-32.67,;29.92,-34.14,;31.39,-34.61,;31.39,-36.15,;29.92,-36.63,;29.02,-35.38,;27.48,-35.38,;26.57,-34.13,;25.09,-34.61,;23.75,-33.84,;22.42,-34.61,;22.42,-36.16,;23.76,-36.93,;25.09,-36.16,;26.57,-36.64,;27.04,-38.1,;28.54,-38.41,;29.03,-39.87,;27.99,-41.03,;26.48,-40.71,;26.01,-39.24,;24.51,-38.92,;23,-38.6,)| Show InChI InChI=1S/C16H10N6O/c17-9-10-5-1-3-7-12(10)22-13-8-4-2-6-11(13)19-16(22)14-15(18)21-23-20-14/h1-8H,(H2,18,21) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
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| Article PubMed
| 26 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Vertex Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description Inhibition of p70S6K assessed as decrease in NADH absorbance at 340 nm in the presence of |
Bioorg Med Chem Lett 19: 5191-4 (2009)
Article DOI: 10.1016/j.bmcl.2009.07.022 BindingDB Entry DOI: 10.7270/Q2KP8287 |
More data for this Ligand-Target Pair | |
Ribosomal protein S6 kinase beta-1
(Homo sapiens (Human)) | BDBM50310466
![PNG](/data/jpeg/tenK5031/BindingDB_50310466.png) (4-(1-(2-methoxyphenyl)-1H-benzo[d]imidazol-2-yl)-1...)Show SMILES COc1ccccc1-n1c(nc2ccccc12)-c1nonc1N |(24.61,-6.88,;25.42,-5.57,;26.96,-5.62,;27.69,-6.97,;29.23,-7.01,;30.03,-5.69,;29.3,-4.35,;27.77,-4.31,;27.04,-2.96,;27.95,-1.7,;27.03,-.45,;25.56,-.93,;24.22,-.16,;22.9,-.93,;22.89,-2.48,;24.23,-3.25,;25.56,-2.48,;29.48,-1.7,;30.39,-2.95,;31.85,-2.47,;31.85,-.93,;30.39,-.46,;29.91,1.01,)| Show InChI InChI=1S/C16H13N5O2/c1-22-13-9-5-4-8-12(13)21-11-7-3-2-6-10(11)18-16(21)14-15(17)20-23-19-14/h2-9H,1H3,(H2,17,20) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| 31 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Vertex Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description Inhibition of p70S6K assessed as decrease in NADH absorbance at 340 nm in the presence of |
Bioorg Med Chem Lett 19: 5191-4 (2009)
Article DOI: 10.1016/j.bmcl.2009.07.022 BindingDB Entry DOI: 10.7270/Q2KP8287 |
More data for this Ligand-Target Pair | |
cAMP-dependent protein kinase catalytic subunit alpha
(Homo sapiens (Human)) | BDBM50310470
![PNG](/data/jpeg/tenK5031/BindingDB_50310470.png) (4-(5-amino-1-cyclobutyl-1H-benzo[d]imidazol-2-yl)-...)Show InChI InChI=1S/C13H14N6O/c14-7-4-5-10-9(6-7)16-13(11-12(15)18-20-17-11)19(10)8-2-1-3-8/h4-6,8H,1-3,14H2,(H2,15,18) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
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Similars
| Article PubMed
| 34 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Vertex Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description Inhibition of PKAalpha assessed as decrease in NADH absorbance at 340 nm in the presence of |
Bioorg Med Chem Lett 19: 5191-4 (2009)
Article DOI: 10.1016/j.bmcl.2009.07.022 BindingDB Entry DOI: 10.7270/Q2KP8287 |
More data for this Ligand-Target Pair | |
Ribosomal protein S6 kinase beta-1
(Homo sapiens (Human)) | BDBM50310471
![PNG](/data/jpeg/tenK5031/BindingDB_50310471.png) (4-(1-cyclobutyl-5-methoxy-1H-benzo[d]imidazol-2-yl...)Show InChI InChI=1S/C14H15N5O2/c1-20-9-5-6-11-10(7-9)16-14(12-13(15)18-21-17-12)19(11)8-3-2-4-8/h5-8H,2-4H2,1H3,(H2,15,18) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
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Similars
| Article PubMed
| 39 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Vertex Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description Inhibition of p70S6K assessed as decrease in NADH absorbance at 340 nm in the presence of |
Bioorg Med Chem Lett 19: 5191-4 (2009)
Article DOI: 10.1016/j.bmcl.2009.07.022 BindingDB Entry DOI: 10.7270/Q2KP8287 |
More data for this Ligand-Target Pair | |
Ribosomal protein S6 kinase beta-1
(Homo sapiens (Human)) | BDBM50310454
![PNG](/data/jpeg/tenK5031/BindingDB_50310454.png) (4-(1-isopropyl-1H-benzo[d]imidazol-2-yl)-1,2,5-oxa...)Show InChI InChI=1S/C12H13N5O/c1-7(2)17-9-6-4-3-5-8(9)14-12(17)10-11(13)16-18-15-10/h3-7H,1-2H3,(H2,13,16) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
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| Article PubMed
| 40 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Vertex Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description Inhibition of p70S6K assessed as decrease in NADH absorbance at 340 nm in the presence of |
Bioorg Med Chem Lett 19: 5191-4 (2009)
Article DOI: 10.1016/j.bmcl.2009.07.022 BindingDB Entry DOI: 10.7270/Q2KP8287 |
More data for this Ligand-Target Pair | |
Ribosomal protein S6 kinase beta-1
(Homo sapiens (Human)) | BDBM50168588
![PNG](/data/jpeg/tenK5016/BindingDB_50168588.png) (4-(1-Ethyl-1H-benzoimidazol-2-yl)-furazan-3-ylamin...)Show InChI InChI=1S/C11H11N5O/c1-2-16-8-6-4-3-5-7(8)13-11(16)9-10(12)15-17-14-9/h3-6H,2H2,1H3,(H2,12,15) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
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Patents
Similars
| Article PubMed
| 50 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Vertex Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description Inhibition of p70S6K assessed as decrease in NADH absorbance at 340 nm in the presence of |
Bioorg Med Chem Lett 19: 5191-4 (2009)
Article DOI: 10.1016/j.bmcl.2009.07.022 BindingDB Entry DOI: 10.7270/Q2KP8287 |
More data for this Ligand-Target Pair | |
Ribosomal protein S6 kinase beta-1
(Homo sapiens (Human)) | BDBM50310460
![PNG](/data/jpeg/tenK5031/BindingDB_50310460.png) (4-(1-(cyclobutylmethyl)-1H-benzo[d]imidazol-2-yl)-...)Show InChI InChI=1S/C14H15N5O/c15-13-12(17-20-18-13)14-16-10-6-1-2-7-11(10)19(14)8-9-4-3-5-9/h1-2,6-7,9H,3-5,8H2,(H2,15,18) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 69 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Vertex Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description Inhibition of p70S6K assessed as decrease in NADH absorbance at 340 nm in the presence of |
Bioorg Med Chem Lett 19: 5191-4 (2009)
Article DOI: 10.1016/j.bmcl.2009.07.022 BindingDB Entry DOI: 10.7270/Q2KP8287 |
More data for this Ligand-Target Pair | |
Rho-associated protein kinase 1
(Homo sapiens (Human)) | BDBM50310470
![PNG](/data/jpeg/tenK5031/BindingDB_50310470.png) (4-(5-amino-1-cyclobutyl-1H-benzo[d]imidazol-2-yl)-...)Show InChI InChI=1S/C13H14N6O/c14-7-4-5-10-9(6-7)16-13(11-12(15)18-20-17-11)19(10)8-2-1-3-8/h4-6,8H,1-3,14H2,(H2,15,18) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 85 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Vertex Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description Inhibition of ROCK1 assessed as decrease in NADH absorbance at 340 nm in the presence of |
Bioorg Med Chem Lett 19: 5191-4 (2009)
Article DOI: 10.1016/j.bmcl.2009.07.022 BindingDB Entry DOI: 10.7270/Q2KP8287 |
More data for this Ligand-Target Pair | |
Ribosomal protein S6 kinase beta-1
(Homo sapiens (Human)) | BDBM50310476
![PNG](/data/jpeg/tenK5031/BindingDB_50310476.png) (4-(1-isobutyl-4-phenyl-1H-imidazol-2-yl)-1,2,5-oxa...)Show InChI InChI=1S/C15H17N5O/c1-10(2)8-20-9-12(11-6-4-3-5-7-11)17-15(20)13-14(16)19-21-18-13/h3-7,9-10H,8H2,1-2H3,(H2,16,19) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| 89 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Vertex Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description Inhibition of p70S6K assessed as decrease in NADH absorbance at 340 nm in the presence of |
Bioorg Med Chem Lett 19: 5191-4 (2009)
Article DOI: 10.1016/j.bmcl.2009.07.022 BindingDB Entry DOI: 10.7270/Q2KP8287 |
More data for this Ligand-Target Pair | |
Ribosomal protein S6 kinase beta-1
(Homo sapiens (Human)) | BDBM50310455
![PNG](/data/jpeg/tenK5031/BindingDB_50310455.png) (4-(1-cyclopropyl-1H-benzo[d]imidazol-2-yl)-1,2,5-o...)Show InChI InChI=1S/C12H11N5O/c13-11-10(15-18-16-11)12-14-8-3-1-2-4-9(8)17(12)7-5-6-7/h1-4,7H,5-6H2,(H2,13,16) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 95 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Vertex Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description Inhibition of p70S6K assessed as decrease in NADH absorbance at 340 nm in the presence of |
Bioorg Med Chem Lett 19: 5191-4 (2009)
Article DOI: 10.1016/j.bmcl.2009.07.022 BindingDB Entry DOI: 10.7270/Q2KP8287 |
More data for this Ligand-Target Pair | |
Ribosomal protein S6 kinase beta-1
(Homo sapiens (Human)) | BDBM50310462
![PNG](/data/jpeg/tenK5031/BindingDB_50310462.png) (4-(1-phenyl-1H-benzo[d]imidazol-2-yl)-1,2,5-oxadia...)Show InChI InChI=1S/C15H11N5O/c16-14-13(18-21-19-14)15-17-11-8-4-5-9-12(11)20(15)10-6-2-1-3-7-10/h1-9H,(H2,16,19) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| 110 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Vertex Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description Inhibition of p70S6K assessed as decrease in NADH absorbance at 340 nm in the presence of |
Bioorg Med Chem Lett 19: 5191-4 (2009)
Article DOI: 10.1016/j.bmcl.2009.07.022 BindingDB Entry DOI: 10.7270/Q2KP8287 |
More data for this Ligand-Target Pair | |
Advanced glycosylation end product-specific receptor
(Homo sapiens (Human)) | BDBM50249567
![PNG](/data/jpeg/tenK5024/BindingDB_50249567.png) (CHEMBL4075936)Show InChI InChI=1S/C20H22ClNO/c21-18-13-11-17(12-14-18)20(23)22(19-9-5-2-6-10-19)15-16-7-3-1-4-8-16/h1,3-4,7-8,11-14,19H,2,5-6,9-10,15H2 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
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| Article PubMed
| 148 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
King's College London
Curated by ChEMBL
| Assay Description Inhibition of HMGB1 binding to human RAGE domain V expressed in CHO cells |
J Med Chem 60: 7213-7232 (2017)
Article DOI: 10.1021/acs.jmedchem.7b00058 BindingDB Entry DOI: 10.7270/Q2KD21BP |
More data for this Ligand-Target Pair | |
Rho-associated protein kinase 1
(Homo sapiens (Human)) | BDBM50310456
![PNG](/data/jpeg/tenK5031/BindingDB_50310456.png) (4-(1-cyclobutyl-1H-benzo[d]imidazol-2-yl)-1,2,5-ox...)Show InChI InChI=1S/C13H13N5O/c14-12-11(16-19-17-12)13-15-9-6-1-2-7-10(9)18(13)8-4-3-5-8/h1-2,6-8H,3-5H2,(H2,14,17) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
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| Article PubMed
| 180 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Vertex Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description Inhibition of ROCK1 assessed as decrease in NADH absorbance at 340 nm in the presence of |
Bioorg Med Chem Lett 19: 5191-4 (2009)
Article DOI: 10.1016/j.bmcl.2009.07.022 BindingDB Entry DOI: 10.7270/Q2KP8287 |
More data for this Ligand-Target Pair | |
Glycogen synthase kinase-3 beta
(Homo sapiens (Human)) | BDBM50310457
![PNG](/data/jpeg/tenK5031/BindingDB_50310457.png) (4-(1-cyclopentyl-1H-benzo[d]imidazol-2-yl)-1,2,5-o...)Show InChI InChI=1S/C14H15N5O/c15-13-12(17-20-18-13)14-16-10-7-3-4-8-11(10)19(14)9-5-1-2-6-9/h3-4,7-9H,1-2,5-6H2,(H2,15,18) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
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| Article PubMed
| 210 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Vertex Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description Inhibition of GSK3beta assessed as decrease in NADH absorbance at 340 nm in the presence of |
Bioorg Med Chem Lett 19: 5191-4 (2009)
Article DOI: 10.1016/j.bmcl.2009.07.022 BindingDB Entry DOI: 10.7270/Q2KP8287 |
More data for this Ligand-Target Pair | |
Advanced glycosylation end product-specific receptor
(Homo sapiens (Human)) | BDBM50249567
![PNG](/data/jpeg/tenK5024/BindingDB_50249567.png) (CHEMBL4075936)Show InChI InChI=1S/C20H22ClNO/c21-18-13-11-17(12-14-18)20(23)22(19-9-5-2-6-10-19)15-16-7-3-1-4-8-16/h1,3-4,7-8,11-14,19H,2,5-6,9-10,15H2 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
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| Article PubMed
| 230 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
King's College London
Curated by ChEMBL
| Assay Description Inhibition of S110B binding to human RAGE domain V expressed in CHO cells |
J Med Chem 60: 7213-7232 (2017)
Article DOI: 10.1021/acs.jmedchem.7b00058 BindingDB Entry DOI: 10.7270/Q2KD21BP |
More data for this Ligand-Target Pair | |
Glycogen synthase kinase-3 beta
(Homo sapiens (Human)) | BDBM50310458
![PNG](/data/jpeg/tenK5031/BindingDB_50310458.png) (4-(1-cyclohexyl-1H-benzo[d]imidazol-2-yl)-1,2,5-ox...)Show InChI InChI=1S/C15H17N5O/c16-14-13(18-21-19-14)15-17-11-8-4-5-9-12(11)20(15)10-6-2-1-3-7-10/h4-5,8-10H,1-3,6-7H2,(H2,16,19) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
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| Article PubMed
| 240 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Vertex Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description Inhibition of GSK3beta assessed as decrease in NADH absorbance at 340 nm in the presence of |
Bioorg Med Chem Lett 19: 5191-4 (2009)
Article DOI: 10.1016/j.bmcl.2009.07.022 BindingDB Entry DOI: 10.7270/Q2KP8287 |
More data for this Ligand-Target Pair | |
Glycogen synthase kinase-3 beta
(Homo sapiens (Human)) | BDBM50310459
![PNG](/data/jpeg/tenK5031/BindingDB_50310459.png) (4-(1-(cyclopropylmethyl)-1H-benzo[d]imidazol-2-yl)...)Show InChI InChI=1S/C13H13N5O/c14-12-11(16-19-17-12)13-15-9-3-1-2-4-10(9)18(13)7-8-5-6-8/h1-4,8H,5-7H2,(H2,14,17) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
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| 290 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Vertex Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description Inhibition of GSK3beta assessed as decrease in NADH absorbance at 340 nm in the presence of |
Bioorg Med Chem Lett 19: 5191-4 (2009)
Article DOI: 10.1016/j.bmcl.2009.07.022 BindingDB Entry DOI: 10.7270/Q2KP8287 |
More data for this Ligand-Target Pair | |
Rho-associated protein kinase 1
(Homo sapiens (Human)) | BDBM50168588
![PNG](/data/jpeg/tenK5016/BindingDB_50168588.png) (4-(1-Ethyl-1H-benzoimidazol-2-yl)-furazan-3-ylamin...)Show InChI InChI=1S/C11H11N5O/c1-2-16-8-6-4-3-5-7(8)13-11(16)9-10(12)15-17-14-9/h3-6H,2H2,1H3,(H2,12,15) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
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| Article PubMed
| 330 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Vertex Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description Inhibition of ROCK1 assessed as decrease in NADH absorbance at 340 nm in the presence of |
Bioorg Med Chem Lett 19: 5191-4 (2009)
Article DOI: 10.1016/j.bmcl.2009.07.022 BindingDB Entry DOI: 10.7270/Q2KP8287 |
More data for this Ligand-Target Pair | |
Ribosomal protein S6 kinase beta-1
(Homo sapiens (Human)) | BDBM50310477
![PNG](/data/jpeg/tenK5031/BindingDB_50310477.png) (4-(1-isobutyl-4-methyl-1H-imidazol-2-yl)-1,2,5-oxa...)Show InChI InChI=1S/C10H15N5O/c1-6(2)4-15-5-7(3)12-10(15)8-9(11)14-16-13-8/h5-6H,4H2,1-3H3,(H2,11,14) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
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| Article PubMed
| 340 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Vertex Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description Inhibition of p70S6K assessed as decrease in NADH absorbance at 340 nm in the presence of |
Bioorg Med Chem Lett 19: 5191-4 (2009)
Article DOI: 10.1016/j.bmcl.2009.07.022 BindingDB Entry DOI: 10.7270/Q2KP8287 |
More data for this Ligand-Target Pair | |
Rho-associated protein kinase 1
(Homo sapiens (Human)) | BDBM50310457
![PNG](/data/jpeg/tenK5031/BindingDB_50310457.png) (4-(1-cyclopentyl-1H-benzo[d]imidazol-2-yl)-1,2,5-o...)Show InChI InChI=1S/C14H15N5O/c15-13-12(17-20-18-13)14-16-10-7-3-4-8-11(10)19(14)9-5-1-2-6-9/h3-4,7-9H,1-2,5-6H2,(H2,15,18) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
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| Article PubMed
| 340 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Vertex Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description Inhibition of ROCK1 assessed as decrease in NADH absorbance at 340 nm in the presence of |
Bioorg Med Chem Lett 19: 5191-4 (2009)
Article DOI: 10.1016/j.bmcl.2009.07.022 BindingDB Entry DOI: 10.7270/Q2KP8287 |
More data for this Ligand-Target Pair | |
Rho-associated protein kinase 1
(Homo sapiens (Human)) | BDBM50310459
![PNG](/data/jpeg/tenK5031/BindingDB_50310459.png) (4-(1-(cyclopropylmethyl)-1H-benzo[d]imidazol-2-yl)...)Show InChI InChI=1S/C13H13N5O/c14-12-11(16-19-17-12)13-15-9-3-1-2-4-10(9)18(13)7-8-5-6-8/h1-4,8H,5-7H2,(H2,14,17) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
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| 360 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Vertex Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description Inhibition of ROCK1 assessed as decrease in NADH absorbance at 340 nm in the presence of |
Bioorg Med Chem Lett 19: 5191-4 (2009)
Article DOI: 10.1016/j.bmcl.2009.07.022 BindingDB Entry DOI: 10.7270/Q2KP8287 |
More data for this Ligand-Target Pair | |
cAMP-dependent protein kinase catalytic subunit alpha
(Homo sapiens (Human)) | BDBM50310459
![PNG](/data/jpeg/tenK5031/BindingDB_50310459.png) (4-(1-(cyclopropylmethyl)-1H-benzo[d]imidazol-2-yl)...)Show InChI InChI=1S/C13H13N5O/c14-12-11(16-19-17-12)13-15-9-3-1-2-4-10(9)18(13)7-8-5-6-8/h1-4,8H,5-7H2,(H2,14,17) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
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| 380 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Vertex Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description Inhibition of PKAalpha assessed as decrease in NADH absorbance at 340 nm in the presence of |
Bioorg Med Chem Lett 19: 5191-4 (2009)
Article DOI: 10.1016/j.bmcl.2009.07.022 BindingDB Entry DOI: 10.7270/Q2KP8287 |
More data for this Ligand-Target Pair | ![3D 3D](/images/Docked_3d.png) 3D Structure (crystal) |
Glycogen synthase kinase-3 beta
(Homo sapiens (Human)) | BDBM50310456
![PNG](/data/jpeg/tenK5031/BindingDB_50310456.png) (4-(1-cyclobutyl-1H-benzo[d]imidazol-2-yl)-1,2,5-ox...)Show InChI InChI=1S/C13H13N5O/c14-12-11(16-19-17-12)13-15-9-6-1-2-7-10(9)18(13)8-4-3-5-8/h1-2,6-8H,3-5H2,(H2,14,17) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
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| Article PubMed
| 380 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Vertex Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description Inhibition of GSK3beta assessed as decrease in NADH absorbance at 340 nm in the presence of |
Bioorg Med Chem Lett 19: 5191-4 (2009)
Article DOI: 10.1016/j.bmcl.2009.07.022 BindingDB Entry DOI: 10.7270/Q2KP8287 |
More data for this Ligand-Target Pair | |
Glycogen synthase kinase-3 beta
(Homo sapiens (Human)) | BDBM50310461
![PNG](/data/jpeg/tenK5031/BindingDB_50310461.png) (4-(1-isobutyl-1H-benzo[d]imidazol-2-yl)-1,2,5-oxad...)Show InChI InChI=1S/C13H15N5O/c1-8(2)7-18-10-6-4-3-5-9(10)15-13(18)11-12(14)17-19-16-11/h3-6,8H,7H2,1-2H3,(H2,14,17) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
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| Article PubMed
| 390 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Vertex Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description Inhibition of GSK3beta assessed as decrease in NADH absorbance at 340 nm in the presence of |
Bioorg Med Chem Lett 19: 5191-4 (2009)
Article DOI: 10.1016/j.bmcl.2009.07.022 BindingDB Entry DOI: 10.7270/Q2KP8287 |
More data for this Ligand-Target Pair | |
Ribosomal protein S6 kinase beta-1
(Homo sapiens (Human)) | BDBM50310472
![PNG](/data/jpeg/tenK5031/BindingDB_50310472.png) (CHEMBL1080073 | methyl 2-(4-amino-1,2,5-oxadiazol-...)Show InChI InChI=1S/C15H15N5O3/c1-22-15(21)8-5-6-11-10(7-8)17-14(12-13(16)19-23-18-12)20(11)9-3-2-4-9/h5-7,9H,2-4H2,1H3,(H2,16,19) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
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Similars
| Article PubMed
| 410 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Vertex Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description Inhibition of p70S6K assessed as decrease in NADH absorbance at 340 nm in the presence of |
Bioorg Med Chem Lett 19: 5191-4 (2009)
Article DOI: 10.1016/j.bmcl.2009.07.022 BindingDB Entry DOI: 10.7270/Q2KP8287 |
More data for this Ligand-Target Pair | |
Rho-associated protein kinase 1
(Homo sapiens (Human)) | BDBM50310455
![PNG](/data/jpeg/tenK5031/BindingDB_50310455.png) (4-(1-cyclopropyl-1H-benzo[d]imidazol-2-yl)-1,2,5-o...)Show InChI InChI=1S/C12H11N5O/c13-11-10(15-18-16-11)12-14-8-3-1-2-4-9(8)17(12)7-5-6-7/h1-4,7H,5-6H2,(H2,13,16) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
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Similars
| Article PubMed
| 450 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Vertex Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description Inhibition of ROCK1 assessed as decrease in NADH absorbance at 340 nm in the presence of |
Bioorg Med Chem Lett 19: 5191-4 (2009)
Article DOI: 10.1016/j.bmcl.2009.07.022 BindingDB Entry DOI: 10.7270/Q2KP8287 |
More data for this Ligand-Target Pair | |
Glycogen synthase kinase-3 beta
(Homo sapiens (Human)) | BDBM50310471
![PNG](/data/jpeg/tenK5031/BindingDB_50310471.png) (4-(1-cyclobutyl-5-methoxy-1H-benzo[d]imidazol-2-yl...)Show InChI InChI=1S/C14H15N5O2/c1-20-9-5-6-11-10(7-9)16-14(12-13(15)18-21-17-12)19(11)8-3-2-4-8/h5-8H,2-4H2,1H3,(H2,15,18) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
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Similars
| Article PubMed
| 460 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Vertex Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description Inhibition of GSK3beta assessed as decrease in NADH absorbance at 340 nm in the presence of |
Bioorg Med Chem Lett 19: 5191-4 (2009)
Article DOI: 10.1016/j.bmcl.2009.07.022 BindingDB Entry DOI: 10.7270/Q2KP8287 |
More data for this Ligand-Target Pair | |
cAMP-dependent protein kinase catalytic subunit alpha
(Homo sapiens (Human)) | BDBM50310456
![PNG](/data/jpeg/tenK5031/BindingDB_50310456.png) (4-(1-cyclobutyl-1H-benzo[d]imidazol-2-yl)-1,2,5-ox...)Show InChI InChI=1S/C13H13N5O/c14-12-11(16-19-17-12)13-15-9-6-1-2-7-10(9)18(13)8-4-3-5-8/h1-2,6-8H,3-5H2,(H2,14,17) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
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Similars
| Article PubMed
| 540 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Vertex Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description Inhibition of PKAalpha assessed as decrease in NADH absorbance at 340 nm in the presence of |
Bioorg Med Chem Lett 19: 5191-4 (2009)
Article DOI: 10.1016/j.bmcl.2009.07.022 BindingDB Entry DOI: 10.7270/Q2KP8287 |
More data for this Ligand-Target Pair | |
Ribosomal protein S6 kinase beta-1
(Homo sapiens (Human)) | BDBM50310453
![PNG](/data/jpeg/tenK5031/BindingDB_50310453.png) (4-(1-methyl-1H-benzo[d]imidazol-2-yl)-1,2,5-oxadia...)Show InChI InChI=1S/C10H9N5O/c1-15-7-5-3-2-4-6(7)12-10(15)8-9(11)14-16-13-8/h2-5H,1H3,(H2,11,14) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
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| Article PubMed
| 540 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Vertex Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description Inhibition of p70S6K assessed as decrease in NADH absorbance at 340 nm in the presence of |
Bioorg Med Chem Lett 19: 5191-4 (2009)
Article DOI: 10.1016/j.bmcl.2009.07.022 BindingDB Entry DOI: 10.7270/Q2KP8287 |
More data for this Ligand-Target Pair | |
Ribosomal protein S6 kinase beta-1
(Homo sapiens (Human)) | BDBM50310468
![PNG](/data/jpeg/tenK5031/BindingDB_50310468.png) (4-(1-(4-methoxyphenyl)-1H-benzo[d]imidazol-2-yl)-1...)Show InChI InChI=1S/C16H13N5O2/c1-22-11-8-6-10(7-9-11)21-13-5-3-2-4-12(13)18-16(21)14-15(17)20-23-19-14/h2-9H,1H3,(H2,17,20) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
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Patents
Similars
| Article PubMed
| 550 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Vertex Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description Inhibition of p70S6K assessed as decrease in NADH absorbance at 340 nm in the presence of |
Bioorg Med Chem Lett 19: 5191-4 (2009)
Article DOI: 10.1016/j.bmcl.2009.07.022 BindingDB Entry DOI: 10.7270/Q2KP8287 |
More data for this Ligand-Target Pair | |
Rho-associated protein kinase 1
(Homo sapiens (Human)) | BDBM50310462
![PNG](/data/jpeg/tenK5031/BindingDB_50310462.png) (4-(1-phenyl-1H-benzo[d]imidazol-2-yl)-1,2,5-oxadia...)Show InChI InChI=1S/C15H11N5O/c16-14-13(18-21-19-14)15-17-11-8-4-5-9-12(11)20(15)10-6-2-1-3-7-10/h1-9H,(H2,16,19) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| 590 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Vertex Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description Inhibition of ROCK1 assessed as decrease in NADH absorbance at 340 nm in the presence of |
Bioorg Med Chem Lett 19: 5191-4 (2009)
Article DOI: 10.1016/j.bmcl.2009.07.022 BindingDB Entry DOI: 10.7270/Q2KP8287 |
More data for this Ligand-Target Pair | |
cAMP-dependent protein kinase catalytic subunit alpha
(Homo sapiens (Human)) | BDBM50310458
![PNG](/data/jpeg/tenK5031/BindingDB_50310458.png) (4-(1-cyclohexyl-1H-benzo[d]imidazol-2-yl)-1,2,5-ox...)Show InChI InChI=1S/C15H17N5O/c16-14-13(18-21-19-14)15-17-11-8-4-5-9-12(11)20(15)10-6-2-1-3-7-10/h4-5,8-10H,1-3,6-7H2,(H2,16,19) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 600 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Vertex Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description Inhibition of PKAalpha assessed as decrease in NADH absorbance at 340 nm in the presence of |
Bioorg Med Chem Lett 19: 5191-4 (2009)
Article DOI: 10.1016/j.bmcl.2009.07.022 BindingDB Entry DOI: 10.7270/Q2KP8287 |
More data for this Ligand-Target Pair | |
Glycogen synthase kinase-3 beta
(Homo sapiens (Human)) | BDBM50310462
![PNG](/data/jpeg/tenK5031/BindingDB_50310462.png) (4-(1-phenyl-1H-benzo[d]imidazol-2-yl)-1,2,5-oxadia...)Show InChI InChI=1S/C15H11N5O/c16-14-13(18-21-19-14)15-17-11-8-4-5-9-12(11)20(15)10-6-2-1-3-7-10/h1-9H,(H2,16,19) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| 620 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Vertex Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description Inhibition of GSK3beta assessed as decrease in NADH absorbance at 340 nm in the presence of |
Bioorg Med Chem Lett 19: 5191-4 (2009)
Article DOI: 10.1016/j.bmcl.2009.07.022 BindingDB Entry DOI: 10.7270/Q2KP8287 |
More data for this Ligand-Target Pair | |
Rho-associated protein kinase 1
(Homo sapiens (Human)) | BDBM50310460
![PNG](/data/jpeg/tenK5031/BindingDB_50310460.png) (4-(1-(cyclobutylmethyl)-1H-benzo[d]imidazol-2-yl)-...)Show InChI InChI=1S/C14H15N5O/c15-13-12(17-20-18-13)14-16-10-6-1-2-7-11(10)19(14)8-9-4-3-5-9/h1-2,6-7,9H,3-5,8H2,(H2,15,18) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 660 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Vertex Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description Inhibition of ROCK1 assessed as decrease in NADH absorbance at 340 nm in the presence of |
Bioorg Med Chem Lett 19: 5191-4 (2009)
Article DOI: 10.1016/j.bmcl.2009.07.022 BindingDB Entry DOI: 10.7270/Q2KP8287 |
More data for this Ligand-Target Pair | |
Glycogen synthase kinase-3 beta
(Homo sapiens (Human)) | BDBM50310460
![PNG](/data/jpeg/tenK5031/BindingDB_50310460.png) (4-(1-(cyclobutylmethyl)-1H-benzo[d]imidazol-2-yl)-...)Show InChI InChI=1S/C14H15N5O/c15-13-12(17-20-18-13)14-16-10-6-1-2-7-11(10)19(14)8-9-4-3-5-9/h1-2,6-7,9H,3-5,8H2,(H2,15,18) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 690 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Vertex Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description Inhibition of GSK3beta assessed as decrease in NADH absorbance at 340 nm in the presence of |
Bioorg Med Chem Lett 19: 5191-4 (2009)
Article DOI: 10.1016/j.bmcl.2009.07.022 BindingDB Entry DOI: 10.7270/Q2KP8287 |
More data for this Ligand-Target Pair | |
Glycogen synthase kinase-3 beta
(Homo sapiens (Human)) | BDBM50310477
![PNG](/data/jpeg/tenK5031/BindingDB_50310477.png) (4-(1-isobutyl-4-methyl-1H-imidazol-2-yl)-1,2,5-oxa...)Show InChI InChI=1S/C10H15N5O/c1-6(2)4-15-5-7(3)12-10(15)8-9(11)14-16-13-8/h5-6H,4H2,1-3H3,(H2,11,14) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| 690 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Vertex Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description Inhibition of GSK3beta assessed as decrease in NADH absorbance at 340 nm in the presence of |
Bioorg Med Chem Lett 19: 5191-4 (2009)
Article DOI: 10.1016/j.bmcl.2009.07.022 BindingDB Entry DOI: 10.7270/Q2KP8287 |
More data for this Ligand-Target Pair | |
Glycogen synthase kinase-3 beta
(Homo sapiens (Human)) | BDBM50168588
![PNG](/data/jpeg/tenK5016/BindingDB_50168588.png) (4-(1-Ethyl-1H-benzoimidazol-2-yl)-furazan-3-ylamin...)Show InChI InChI=1S/C11H11N5O/c1-2-16-8-6-4-3-5-7(8)13-11(16)9-10(12)15-17-14-9/h3-6H,2H2,1H3,(H2,12,15) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| Purchase
CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| 700 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Vertex Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description Inhibition of GSK3beta assessed as decrease in NADH absorbance at 340 nm in the presence of |
Bioorg Med Chem Lett 19: 5191-4 (2009)
Article DOI: 10.1016/j.bmcl.2009.07.022 BindingDB Entry DOI: 10.7270/Q2KP8287 |
More data for this Ligand-Target Pair | |
cAMP-dependent protein kinase catalytic subunit alpha
(Homo sapiens (Human)) | BDBM50310457
![PNG](/data/jpeg/tenK5031/BindingDB_50310457.png) (4-(1-cyclopentyl-1H-benzo[d]imidazol-2-yl)-1,2,5-o...)Show InChI InChI=1S/C14H15N5O/c15-13-12(17-20-18-13)14-16-10-7-3-4-8-11(10)19(14)9-5-1-2-6-9/h3-4,7-9H,1-2,5-6H2,(H2,15,18) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 720 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Vertex Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description Inhibition of PKAalpha assessed as decrease in NADH absorbance at 340 nm in the presence of |
Bioorg Med Chem Lett 19: 5191-4 (2009)
Article DOI: 10.1016/j.bmcl.2009.07.022 BindingDB Entry DOI: 10.7270/Q2KP8287 |
More data for this Ligand-Target Pair | |
Rho-associated protein kinase 1
(Homo sapiens (Human)) | BDBM50310458
![PNG](/data/jpeg/tenK5031/BindingDB_50310458.png) (4-(1-cyclohexyl-1H-benzo[d]imidazol-2-yl)-1,2,5-ox...)Show InChI InChI=1S/C15H17N5O/c16-14-13(18-21-19-14)15-17-11-8-4-5-9-12(11)20(15)10-6-2-1-3-7-10/h4-5,8-10H,1-3,6-7H2,(H2,16,19) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 720 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Vertex Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description Inhibition of ROCK1 assessed as decrease in NADH absorbance at 340 nm in the presence of |
Bioorg Med Chem Lett 19: 5191-4 (2009)
Article DOI: 10.1016/j.bmcl.2009.07.022 BindingDB Entry DOI: 10.7270/Q2KP8287 |
More data for this Ligand-Target Pair | |
Ribosomal protein S6 kinase beta-1
(Homo sapiens (Human)) | BDBM50310465
![PNG](/data/jpeg/tenK5031/BindingDB_50310465.png) (4-(2-(4-amino-1,2,5-oxadiazol-3-yl)-1H-benzo[d]imi...)Show InChI InChI=1S/C16H10N6O/c17-9-10-5-7-11(8-6-10)22-13-4-2-1-3-12(13)19-16(22)14-15(18)21-23-20-14/h1-8H,(H2,18,21) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| 800 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Vertex Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description Inhibition of p70S6K assessed as decrease in NADH absorbance at 340 nm in the presence of |
Bioorg Med Chem Lett 19: 5191-4 (2009)
Article DOI: 10.1016/j.bmcl.2009.07.022 BindingDB Entry DOI: 10.7270/Q2KP8287 |
More data for this Ligand-Target Pair | |
Ribosomal protein S6 kinase beta-1
(Homo sapiens (Human)) | BDBM50310464
![PNG](/data/jpeg/tenK5031/BindingDB_50310464.png) (3-(2-(4-amino-1,2,5-oxadiazol-3-yl)-1H-benzo[d]imi...)Show InChI InChI=1S/C16H10N6O/c17-9-10-4-3-5-11(8-10)22-13-7-2-1-6-12(13)19-16(22)14-15(18)21-23-20-14/h1-8H,(H2,18,21) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| 800 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Vertex Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description Inhibition of p70S6K assessed as decrease in NADH absorbance at 340 nm in the presence of |
Bioorg Med Chem Lett 19: 5191-4 (2009)
Article DOI: 10.1016/j.bmcl.2009.07.022 BindingDB Entry DOI: 10.7270/Q2KP8287 |
More data for this Ligand-Target Pair | |
Rho-associated protein kinase 1
(Homo sapiens (Human)) | BDBM50310463
![PNG](/data/jpeg/tenK5031/BindingDB_50310463.png) (2-(2-(4-amino-1,2,5-oxadiazol-3-yl)-1H-benzo[d]imi...)Show SMILES Nc1nonc1-c1nc2ccccc2n1-c1ccccc1C#N |(29.45,-32.67,;29.92,-34.14,;31.39,-34.61,;31.39,-36.15,;29.92,-36.63,;29.02,-35.38,;27.48,-35.38,;26.57,-34.13,;25.09,-34.61,;23.75,-33.84,;22.42,-34.61,;22.42,-36.16,;23.76,-36.93,;25.09,-36.16,;26.57,-36.64,;27.04,-38.1,;28.54,-38.41,;29.03,-39.87,;27.99,-41.03,;26.48,-40.71,;26.01,-39.24,;24.51,-38.92,;23,-38.6,)| Show InChI InChI=1S/C16H10N6O/c17-9-10-5-1-3-7-12(10)22-13-8-4-2-6-11(13)19-16(22)14-15(18)21-23-20-14/h1-8H,(H2,18,21) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| 810 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Vertex Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description Inhibition of ROCK1 assessed as decrease in NADH absorbance at 340 nm in the presence of |
Bioorg Med Chem Lett 19: 5191-4 (2009)
Article DOI: 10.1016/j.bmcl.2009.07.022 BindingDB Entry DOI: 10.7270/Q2KP8287 |
More data for this Ligand-Target Pair | |