Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Bcl-2-like protein 1 (Homo sapiens (Human)) | BDBM50308110![]() ((S,Z)-2-(5-((6-(2,3-dimethoxyphenyl)pyridin-3-yl)m...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 3.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Institute of Chemical and Engineering Sciences Curated by ChEMBL | Assay Description Binding affinity to human Bcl-XL by isothermal titration calorimetry | J Med Chem 53: 2314-8 (2010) Article DOI: 10.1021/jm901469p BindingDB Entry DOI: 10.7270/Q2K937NJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Bcl-2-like protein 1 (Homo sapiens (Human)) | BDBM50308110![]() ((S,Z)-2-(5-((6-(2,3-dimethoxyphenyl)pyridin-3-yl)m...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 3.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Institute of Chemical and Engineering Sciences Curated by ChEMBL | Assay Description Displacement of fluorescein-labeled Bak-BH3 peptide from human Bcl-XL by fluorescence polarization assay | J Med Chem 53: 2314-8 (2010) Article DOI: 10.1021/jm901469p BindingDB Entry DOI: 10.7270/Q2K937NJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Bcl-2-like protein 1 (Homo sapiens (Human)) | BDBM50107130![]() ((Z)-2-(5-(4-bromobenzylidene)-4-oxo-2-thioxothiazo...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 8.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Institute of Chemical and Engineering Sciences Curated by ChEMBL | Assay Description Binding affinity to human Bcl-XL by isothermal titration calorimetry | J Med Chem 53: 2314-8 (2010) Article DOI: 10.1021/jm901469p BindingDB Entry DOI: 10.7270/Q2K937NJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Bcl-2-like protein 1 (Homo sapiens (Human)) | BDBM50107130![]() ((Z)-2-(5-(4-bromobenzylidene)-4-oxo-2-thioxothiazo...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Institute of Chemical and Engineering Sciences Curated by ChEMBL | Assay Description Displacement of fluorescein-labeled Bak-BH3 peptide from human Bcl-XL by fluorescence polarization assay | J Med Chem 53: 2314-8 (2010) Article DOI: 10.1021/jm901469p BindingDB Entry DOI: 10.7270/Q2K937NJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Bcl-2-like protein 1 (Homo sapiens (Human)) | BDBM50308111![]() ((S,Z)-2-(5-((6-(3,4-dimethoxyphenyl)pyridin-3-yl)m...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Institute of Chemical and Engineering Sciences Curated by ChEMBL | Assay Description Displacement of fluorescein-labeled Bak-BH3 peptide from human Bcl-XL by fluorescence polarization assay | J Med Chem 53: 2314-8 (2010) Article DOI: 10.1021/jm901469p BindingDB Entry DOI: 10.7270/Q2K937NJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Bcl-2-like protein 1 (Homo sapiens (Human)) | BDBM50308111![]() ((S,Z)-2-(5-((6-(3,4-dimethoxyphenyl)pyridin-3-yl)m...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | >7.50E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Institute of Chemical and Engineering Sciences Curated by ChEMBL | Assay Description Binding affinity to human Bcl-XL by isothermal titration calorimetry | J Med Chem 53: 2314-8 (2010) Article DOI: 10.1021/jm901469p BindingDB Entry DOI: 10.7270/Q2K937NJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Bcl-2-like protein 1 (Homo sapiens (Human)) | BDBM25537![]() (4-(2-hydroxyethyl)-8-methyl-12,14-dioxa-8-azatetra...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 3.00E+3 | n/a | n/a | n/a | n/a | 8.0 | 22 |
A*STAR | Assay Description In the fluorescence polarization assay, the Bcl-XL protein is incubated with a fluorescein-tagged Bak-BH3 peptide. The Bcl-XL:Bak-BH3 peptide complex... | J Med Chem 51: 6699-710 (2008) Article DOI: 10.1021/jm8005433 BindingDB Entry DOI: 10.7270/Q25M641R | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Bcl-2-like protein 1 (Homo sapiens (Human)) | BDBM50293171![]() ((1R,2S,4S,6E,8S,11R,12R,13S,14R,15R,22R)-13-hydrox...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 5.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
MerLion Pharmaceuticals Pte Ltd Curated by ChEMBL | Assay Description Inhibition of interaction between GST-tagged Bcl-xl and Bak by fluorescence polarization assay | Bioorg Med Chem Lett 18: 5771-3 (2009) Article DOI: 10.1016/j.bmcl.2008.09.071 BindingDB Entry DOI: 10.7270/Q2DF6R7B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Bcl-2-like protein 1 (Homo sapiens (Human)) | BDBM25539![]() (4-(2-methoxyethyl)-8-methyl-12,14-dioxa-8-azatetra...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 6.00E+3 | n/a | n/a | n/a | n/a | 8.0 | 22 |
A*STAR | Assay Description In the fluorescence polarization assay, the Bcl-XL protein is incubated with a fluorescein-tagged Bak-BH3 peptide. The Bcl-XL:Bak-BH3 peptide complex... | J Med Chem 51: 6699-710 (2008) Article DOI: 10.1021/jm8005433 BindingDB Entry DOI: 10.7270/Q25M641R | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Bcl-2-like protein 1 (Homo sapiens (Human)) | BDBM50293172![]() ((1R,2S,4S,6E,8S,11R,12R,13S,14R,15R,22R)-13-hydrox...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 9.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
MerLion Pharmaceuticals Pte Ltd Curated by ChEMBL | Assay Description Inhibition of interaction between GST-tagged Bcl-xl and Bak by fluorescence polarization assay | Bioorg Med Chem Lett 18: 5771-3 (2009) Article DOI: 10.1016/j.bmcl.2008.09.071 BindingDB Entry DOI: 10.7270/Q2DF6R7B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Bcl-2-like protein 1 (Homo sapiens (Human)) | BDBM25536![]() (4-(hydroxymethyl)-8-methyl-12,14-dioxa-8-azatetrac...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.10E+4 | n/a | n/a | n/a | n/a | 8.0 | 22 |
A*STAR | Assay Description In the fluorescence polarization assay, the Bcl-XL protein is incubated with a fluorescein-tagged Bak-BH3 peptide. The Bcl-XL:Bak-BH3 peptide complex... | J Med Chem 51: 6699-710 (2008) Article DOI: 10.1021/jm8005433 BindingDB Entry DOI: 10.7270/Q25M641R | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Bcl-2-like protein 1 (Homo sapiens (Human)) | BDBM25538![]() (4-(methoxymethyl)-8-methyl-12,14-dioxa-8-azatetrac...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.10E+4 | n/a | n/a | n/a | n/a | 8.0 | 22 |
A*STAR | Assay Description In the fluorescence polarization assay, the Bcl-XL protein is incubated with a fluorescein-tagged Bak-BH3 peptide. The Bcl-XL:Bak-BH3 peptide complex... | J Med Chem 51: 6699-710 (2008) Article DOI: 10.1021/jm8005433 BindingDB Entry DOI: 10.7270/Q25M641R | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Bcl-2-like protein 1 (Homo sapiens (Human)) | BDBM25530![]() (8-methyl-12,14-dioxa-8-azatetracyclo[8.7.0.0^{2,7}...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.20E+4 | n/a | n/a | n/a | n/a | 8.0 | 22 |
A*STAR | Assay Description In the fluorescence polarization assay, the Bcl-XL protein is incubated with a fluorescein-tagged Bak-BH3 peptide. The Bcl-XL:Bak-BH3 peptide complex... | J Med Chem 51: 6699-710 (2008) Article DOI: 10.1021/jm8005433 BindingDB Entry DOI: 10.7270/Q25M641R | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Bcl-2-like protein 1 (Homo sapiens (Human)) | BDBM50293169![]() (CHEMBL523927 | kendomycin) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.23E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
MerLion Pharmaceuticals Pte Ltd Curated by ChEMBL | Assay Description Inhibition of interaction between GST-tagged Bcl-xl and Bak by fluorescence polarization assay | Bioorg Med Chem Lett 18: 5771-3 (2009) Article DOI: 10.1016/j.bmcl.2008.09.071 BindingDB Entry DOI: 10.7270/Q2DF6R7B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Bcl-2-like protein 1 (Homo sapiens (Human)) | BDBM25540![]() (7,8-dihydroxy-5-methylphenanthridin-5-ium chloride...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.80E+4 | n/a | n/a | n/a | n/a | 8.0 | 22 |
A*STAR | Assay Description In the fluorescence polarization assay, the Bcl-XL protein is incubated with a fluorescein-tagged Bak-BH3 peptide. The Bcl-XL:Bak-BH3 peptide complex... | J Med Chem 51: 6699-710 (2008) Article DOI: 10.1021/jm8005433 BindingDB Entry DOI: 10.7270/Q25M641R | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Bcl-2-like protein 1 (Homo sapiens (Human)) | BDBM25525![]() (24-methyl-5,7,18,20-tetraoxa-24-azahexacyclo[11.11...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | Purchase CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 1.90E+4 | n/a | n/a | n/a | n/a | 8.0 | 22 |
A*STAR | Assay Description In the fluorescence polarization assay, the Bcl-XL protein is incubated with a fluorescein-tagged Bak-BH3 peptide. The Bcl-XL:Bak-BH3 peptide complex... | J Med Chem 51: 6699-710 (2008) Article DOI: 10.1021/jm8005433 BindingDB Entry DOI: 10.7270/Q25M641R | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Bcl-2-like protein 1 (Homo sapiens (Human)) | BDBM25541![]() (7,8-dihydroxy-2-(hydroxymethyl)-5-methylphenanthri...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 2.00E+4 | n/a | n/a | n/a | n/a | 8.0 | 22 |
A*STAR | Assay Description In the fluorescence polarization assay, the Bcl-XL protein is incubated with a fluorescein-tagged Bak-BH3 peptide. The Bcl-XL:Bak-BH3 peptide complex... | J Med Chem 51: 6699-710 (2008) Article DOI: 10.1021/jm8005433 BindingDB Entry DOI: 10.7270/Q25M641R | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Bcl-2-like protein 1 (Homo sapiens (Human)) | BDBM25542![]() (7,8-dihydroxy-2-(2-hydroxyethyl)-5-methylphenanthr...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 2.20E+4 | n/a | n/a | n/a | n/a | 8.0 | 22 |
A*STAR | Assay Description In the fluorescence polarization assay, the Bcl-XL protein is incubated with a fluorescein-tagged Bak-BH3 peptide. The Bcl-XL:Bak-BH3 peptide complex... | J Med Chem 51: 6699-710 (2008) Article DOI: 10.1021/jm8005433 BindingDB Entry DOI: 10.7270/Q25M641R | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Bcl-2-like protein 1 (Homo sapiens (Human)) | BDBM25534![]() (13,13-dimethyl-8-oxido-12,14-dioxa-8-azatetracyclo...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | 8.0 | 22 |
A*STAR | Assay Description In the fluorescence polarization assay, the Bcl-XL protein is incubated with a fluorescein-tagged Bak-BH3 peptide. The Bcl-XL:Bak-BH3 peptide complex... | J Med Chem 51: 6699-710 (2008) Article DOI: 10.1021/jm8005433 BindingDB Entry DOI: 10.7270/Q25M641R | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Bcl-2-like protein 1 (Homo sapiens (Human)) | BDBM25532![]() (7,8-dimethoxy-5-oxidophenanthridin-5-ium | chelery...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | 8.0 | 22 |
A*STAR | Assay Description In the fluorescence polarization assay, the Bcl-XL protein is incubated with a fluorescein-tagged Bak-BH3 peptide. The Bcl-XL:Bak-BH3 peptide complex... | J Med Chem 51: 6699-710 (2008) Article DOI: 10.1021/jm8005433 BindingDB Entry DOI: 10.7270/Q25M641R | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Bcl-2-like protein 1 (Homo sapiens (Human)) | BDBM25524![]() (17,18-dimethoxy-21-methyl-5,7-dioxa-21-azapentacyc...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | Purchase CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 1.00E+5 | n/a | n/a | n/a | n/a | 8.0 | 22 |
A*STAR | Assay Description In the fluorescence polarization assay, the Bcl-XL protein is incubated with a fluorescein-tagged Bak-BH3 peptide. The Bcl-XL:Bak-BH3 peptide complex... | J Med Chem 51: 6699-710 (2008) Article DOI: 10.1021/jm8005433 BindingDB Entry DOI: 10.7270/Q25M641R | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Bcl-2-like protein 1 (Homo sapiens (Human)) | BDBM25526![]() (7,8-dimethoxyphenanthridine | chelerythrine analog...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | 8.0 | 22 |
A*STAR | Assay Description In the fluorescence polarization assay, the Bcl-XL protein is incubated with a fluorescein-tagged Bak-BH3 peptide. The Bcl-XL:Bak-BH3 peptide complex... | J Med Chem 51: 6699-710 (2008) Article DOI: 10.1021/jm8005433 BindingDB Entry DOI: 10.7270/Q25M641R | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Bcl-2-like protein 1 (Homo sapiens (Human)) | BDBM25527![]() (12,14-dioxa-8-azatetracyclo[8.7.0.0^{2,7}.0^{11,15...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | 8.0 | 22 |
A*STAR | Assay Description In the fluorescence polarization assay, the Bcl-XL protein is incubated with a fluorescein-tagged Bak-BH3 peptide. The Bcl-XL:Bak-BH3 peptide complex... | J Med Chem 51: 6699-710 (2008) Article DOI: 10.1021/jm8005433 BindingDB Entry DOI: 10.7270/Q25M641R | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Bcl-2-like protein 1 (Homo sapiens (Human)) | BDBM25528![]() (13,13-dimethyl-12,14-dioxa-8-azatetracyclo[8.7.0.0...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | 8.0 | 22 |
A*STAR | Assay Description In the fluorescence polarization assay, the Bcl-XL protein is incubated with a fluorescein-tagged Bak-BH3 peptide. The Bcl-XL:Bak-BH3 peptide complex... | J Med Chem 51: 6699-710 (2008) Article DOI: 10.1021/jm8005433 BindingDB Entry DOI: 10.7270/Q25M641R | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Bcl-2-like protein 1 (Homo sapiens (Human)) | BDBM25529![]() (7,8-dimethoxy-5-methylphenanthridin-5-ium iodide |...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | 8.0 | 22 |
A*STAR | Assay Description In the fluorescence polarization assay, the Bcl-XL protein is incubated with a fluorescein-tagged Bak-BH3 peptide. The Bcl-XL:Bak-BH3 peptide complex... | J Med Chem 51: 6699-710 (2008) Article DOI: 10.1021/jm8005433 BindingDB Entry DOI: 10.7270/Q25M641R | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Bcl-2-like protein 1 (Homo sapiens (Human)) | BDBM25531![]() (8,13,13-trimethyl-12,14-dioxa-8-azatetracyclo[8.7....) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | 8.0 | 22 |
A*STAR | Assay Description In the fluorescence polarization assay, the Bcl-XL protein is incubated with a fluorescein-tagged Bak-BH3 peptide. The Bcl-XL:Bak-BH3 peptide complex... | J Med Chem 51: 6699-710 (2008) Article DOI: 10.1021/jm8005433 BindingDB Entry DOI: 10.7270/Q25M641R | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Bcl-2-like protein 1 (Homo sapiens (Human)) | BDBM25535![]() (2-(hydroxymethyl)-7,8-dimethoxy-5-methylphenanthri...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | 8.0 | 22 |
A*STAR | Assay Description In the fluorescence polarization assay, the Bcl-XL protein is incubated with a fluorescein-tagged Bak-BH3 peptide. The Bcl-XL:Bak-BH3 peptide complex... | J Med Chem 51: 6699-710 (2008) Article DOI: 10.1021/jm8005433 BindingDB Entry DOI: 10.7270/Q25M641R | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Bcl-2-like protein 1 (Homo sapiens (Human)) | BDBM25533![]() (8-oxido-12,14-dioxa-8-azatetracyclo[8.7.0.0^{2,7}....) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | 8.0 | 22 |
A*STAR | Assay Description In the fluorescence polarization assay, the Bcl-XL protein is incubated with a fluorescein-tagged Bak-BH3 peptide. The Bcl-XL:Bak-BH3 peptide complex... | J Med Chem 51: 6699-710 (2008) Article DOI: 10.1021/jm8005433 BindingDB Entry DOI: 10.7270/Q25M641R | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Bcl-2-like protein 1 (Homo sapiens (Human)) | BDBM50293170![]() ((1R,12S,16S,19R,20R,21S,22R)-4,8,21-Trihydroxy-10-...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem | Article PubMed | n/a | n/a | 2.30E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
MerLion Pharmaceuticals Pte Ltd Curated by ChEMBL | Assay Description Inhibition of interaction between GST-tagged Bcl-xl and Bak by fluorescence polarization assay | Bioorg Med Chem Lett 18: 5771-3 (2009) Article DOI: 10.1016/j.bmcl.2008.09.071 BindingDB Entry DOI: 10.7270/Q2DF6R7B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Induced myeloid leukemia cell differentiation protein Mcl-1 (Homo sapiens (Human)) | BDBM50308110![]() ((S,Z)-2-(5-((6-(2,3-dimethoxyphenyl)pyridin-3-yl)m...) | PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | 6.90E+3 | n/a | n/a | n/a | n/a | n/a |
Institute of Chemical and Engineering Sciences Curated by ChEMBL | Assay Description Displacement of fluorescein-labeled Bak-BH3 peptide from human Mcl1 by fluorescence polarization assay | J Med Chem 53: 2314-8 (2010) Article DOI: 10.1021/jm901469p BindingDB Entry DOI: 10.7270/Q2K937NJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Induced myeloid leukemia cell differentiation protein Mcl-1 (Homo sapiens (Human)) | BDBM50308111![]() ((S,Z)-2-(5-((6-(3,4-dimethoxyphenyl)pyridin-3-yl)m...) | PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | 8.00E+3 | n/a | n/a | n/a | n/a | n/a |
Institute of Chemical and Engineering Sciences Curated by ChEMBL | Assay Description Displacement of fluorescein-labeled Bak-BH3 peptide from human Mcl1 by fluorescence polarization assay | J Med Chem 53: 2314-8 (2010) Article DOI: 10.1021/jm901469p BindingDB Entry DOI: 10.7270/Q2K937NJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Induced myeloid leukemia cell differentiation protein Mcl-1 (Homo sapiens (Human)) | BDBM50107130![]() ((Z)-2-(5-(4-bromobenzylidene)-4-oxo-2-thioxothiazo...) | PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet ![]() | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | 4.40E+4 | n/a | n/a | n/a | n/a | n/a |
Institute of Chemical and Engineering Sciences Curated by ChEMBL | Assay Description Displacement of fluorescein-labeled Bak-BH3 peptide from human Mcl1 by fluorescence polarization assay | J Med Chem 53: 2314-8 (2010) Article DOI: 10.1021/jm901469p BindingDB Entry DOI: 10.7270/Q2K937NJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Induced myeloid leukemia cell differentiation protein Mcl-1 (Homo sapiens (Human)) | BDBM50308110![]() ((S,Z)-2-(5-((6-(2,3-dimethoxyphenyl)pyridin-3-yl)m...) | PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | 250 | n/a | n/a | n/a | n/a | n/a |
Institute of Chemical and Engineering Sciences Curated by ChEMBL | Assay Description Binding affinity to human Mcl1 by isothermal titration calorimetry | J Med Chem 53: 2314-8 (2010) Article DOI: 10.1021/jm901469p BindingDB Entry DOI: 10.7270/Q2K937NJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Bcl-2-like protein 1 (Homo sapiens (Human)) | BDBM50293169![]() (CHEMBL523927 | kendomycin) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | 5.28E+5 | n/a | n/a | n/a | n/a | n/a |
MerLion Pharmaceuticals Pte Ltd Curated by ChEMBL | Assay Description Inhibition of interaction between GST-tagged Bcl-xl and Bak by surface plasmon resonance assay | Bioorg Med Chem Lett 18: 5771-3 (2009) Article DOI: 10.1016/j.bmcl.2008.09.071 BindingDB Entry DOI: 10.7270/Q2DF6R7B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Bcl-2-like protein 1 (Homo sapiens (Human)) | BDBM23223![]() (7-[8-formyl-1,6,7-trihydroxy-3-methyl-5-(propan-2-...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | Purchase CHEMBL MCE KEGG PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | 3.38E+5 | n/a | n/a | n/a | n/a | n/a |
MerLion Pharmaceuticals Pte Ltd Curated by ChEMBL | Assay Description Inhibition of interaction between Bcl-xl and Bak by surface plasmon resonance assay | Bioorg Med Chem Lett 18: 5771-3 (2009) Article DOI: 10.1016/j.bmcl.2008.09.071 BindingDB Entry DOI: 10.7270/Q2DF6R7B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Bcl-2-like protein 1 (Homo sapiens (Human)) | BDBM50293171![]() ((1R,2S,4S,6E,8S,11R,12R,13S,14R,15R,22R)-13-hydrox...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | 3.99E+5 | n/a | n/a | n/a | n/a | n/a |
MerLion Pharmaceuticals Pte Ltd Curated by ChEMBL | Assay Description Inhibition of interaction between Bcl-xl and Bak by surface plasmon resonance assay | Bioorg Med Chem Lett 18: 5771-3 (2009) Article DOI: 10.1016/j.bmcl.2008.09.071 BindingDB Entry DOI: 10.7270/Q2DF6R7B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Bcl-2-like protein 1 (Homo sapiens (Human)) | BDBM50293169![]() (CHEMBL523927 | kendomycin) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | 1.83E+6 | n/a | n/a | n/a | n/a | n/a |
MerLion Pharmaceuticals Pte Ltd Curated by ChEMBL | Assay Description Inhibition of interaction between Bcl-xl and Bak by surface plasmon resonance assay | Bioorg Med Chem Lett 18: 5771-3 (2009) Article DOI: 10.1016/j.bmcl.2008.09.071 BindingDB Entry DOI: 10.7270/Q2DF6R7B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Bcl-2-like protein 1 (Homo sapiens (Human)) | BDBM23223![]() (7-[8-formyl-1,6,7-trihydroxy-3-methyl-5-(propan-2-...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | Purchase CHEMBL MCE KEGG PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | 1.71E+3 | n/a | n/a | n/a | n/a | n/a |
MerLion Pharmaceuticals Pte Ltd Curated by ChEMBL | Assay Description Inhibition of interaction between GST-tagged Bcl-xl and Bak by surface plasmon resonance assay | Bioorg Med Chem Lett 18: 5771-3 (2009) Article DOI: 10.1016/j.bmcl.2008.09.071 BindingDB Entry DOI: 10.7270/Q2DF6R7B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Bcl-2-like protein 1 (Homo sapiens (Human)) | BDBM50293171![]() ((1R,2S,4S,6E,8S,11R,12R,13S,14R,15R,22R)-13-hydrox...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | 3.77E+5 | n/a | n/a | n/a | n/a | n/a |
MerLion Pharmaceuticals Pte Ltd Curated by ChEMBL | Assay Description Inhibition of interaction between GST-tagged Bcl-xl and Bak by surface plasmon resonance assay | Bioorg Med Chem Lett 18: 5771-3 (2009) Article DOI: 10.1016/j.bmcl.2008.09.071 BindingDB Entry DOI: 10.7270/Q2DF6R7B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Bcl-2-like protein 1 (Homo sapiens (Human)) | BDBM50293170![]() ((1R,12S,16S,19R,20R,21S,22R)-4,8,21-Trihydroxy-10-...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | 1.08E+7 | n/a | n/a | n/a | n/a | n/a |
MerLion Pharmaceuticals Pte Ltd Curated by ChEMBL | Assay Description Inhibition of interaction between GST-tagged Bcl-xl and Bak by surface plasmon resonance assay | Bioorg Med Chem Lett 18: 5771-3 (2009) Article DOI: 10.1016/j.bmcl.2008.09.071 BindingDB Entry DOI: 10.7270/Q2DF6R7B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Induced myeloid leukemia cell differentiation protein Mcl-1 (Homo sapiens (Human)) | BDBM50308111![]() ((S,Z)-2-(5-((6-(3,4-dimethoxyphenyl)pyridin-3-yl)m...) | PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | 1.00E+4 | n/a | n/a | n/a | n/a | n/a |
Institute of Chemical and Engineering Sciences Curated by ChEMBL | Assay Description Binding affinity to human Mcl1 by isothermal titration calorimetry | J Med Chem 53: 2314-8 (2010) Article DOI: 10.1021/jm901469p BindingDB Entry DOI: 10.7270/Q2K937NJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Induced myeloid leukemia cell differentiation protein Mcl-1 (Homo sapiens (Human)) | BDBM50107130![]() ((Z)-2-(5-(4-bromobenzylidene)-4-oxo-2-thioxothiazo...) | PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet ![]() | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | 8.40E+4 | n/a | n/a | n/a | n/a | n/a |
Institute of Chemical and Engineering Sciences Curated by ChEMBL | Assay Description Binding affinity to human Mcl1 by isothermal titration calorimetry | J Med Chem 53: 2314-8 (2010) Article DOI: 10.1021/jm901469p BindingDB Entry DOI: 10.7270/Q2K937NJ | |||||||||||
More data for this Ligand-Target Pair |