Compile Data Set for Download or QSAR

Found 161 hits with Last Name = 'begum' and Initial = 'h'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Proto-oncogene tyrosine-protein kinase receptor Ret (Homo sapiens (Human))	BDBM50165968 (CHEMBL3797261) Show SMILES COc1cc2c(Nc3c(F)ccc(O)c3C)ncnc2cc1OCCCN1CCNCC1 Show InChI InChI=1S/C23H28FN5O3/c1-15-19(30)5-4-17(24)22(15)28-23-16-12-20(31-2)21(13-18(16)26-14-27-23)32-11-3-8-29-9-6-25-7-10-29/h4-5,12-14,25,30H,3,6-11H2,1-2H3,(H,26,27,28)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
University of Manchester Curated by ChEMBL					Assay Description Inhibition of N-terminal GST fused human RET (658 to 1114 amino acid residue) using CSKtide as substrate expressed in baculovirus preincubated for 15...				Bioorg Med Chem Lett 26: 2724-9 (2016) Article DOI: 10.1016/j.bmcl.2016.03.100 BindingDB Entry DOI: 10.7270/Q2WM1G93
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret (Homo sapiens (Human))	BDBM50165922 (CHEMBL3799523) Show SMILES COc1cc2c(Nc3c(F)ccc(O)c3C)ncnc2cc1OCCCN(C)C Show InChI InChI=1S/C21H25FN4O3/c1-13-17(27)7-6-15(22)20(13)25-21-14-10-18(28-4)19(11-16(14)23-12-24-21)29-9-5-8-26(2)3/h6-7,10-12,27H,5,8-9H2,1-4H3,(H,23,24,25)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	7	n/a	n/a	n/a	n/a	n/a	n/a
University of Manchester Curated by ChEMBL					Assay Description Inhibition of N-terminal GST fused human RET (658 to 1114 amino acid residue) using CSKtide as substrate expressed in baculovirus preincubated for 15...				Bioorg Med Chem Lett 26: 2724-9 (2016) Article DOI: 10.1016/j.bmcl.2016.03.100 BindingDB Entry DOI: 10.7270/Q2WM1G93
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret (Homo sapiens (Human))	BDBM50165977 (CHEMBL3798584) Show SMILES COc1cc2c(Nc3c(F)ccc(O)c3C)ncnc2cc1OCCCN1CCS(=O)(=O)CC1 Show InChI InChI=1S/C23H27FN4O5S/c1-15-19(29)5-4-17(24)22(15)27-23-16-12-20(32-2)21(13-18(16)25-14-26-23)33-9-3-6-28-7-10-34(30,31)11-8-28/h4-5,12-14,29H,3,6-11H2,1-2H3,(H,25,26,27)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	9	n/a	n/a	n/a	n/a	n/a	n/a
University of Manchester Curated by ChEMBL					Assay Description Inhibition of N-terminal GST fused human RET (658 to 1114 amino acid residue) using CSKtide as substrate expressed in baculovirus preincubated for 15...				Bioorg Med Chem Lett 26: 2724-9 (2016) Article DOI: 10.1016/j.bmcl.2016.03.100 BindingDB Entry DOI: 10.7270/Q2WM1G93
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret (Homo sapiens (Human))	BDBM50165970 (CHEMBL3799971) Show SMILES COc1cc2c(Nc3c(F)ccc(O)c3C)ncnc2cc1OCCCN1CCCNCC1 Show InChI InChI=1S/C24H30FN5O3/c1-16-20(31)6-5-18(25)23(16)29-24-17-13-21(32-2)22(14-19(17)27-15-28-24)33-12-4-10-30-9-3-7-26-8-11-30/h5-6,13-15,26,31H,3-4,7-12H2,1-2H3,(H,27,28,29)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	11	n/a	n/a	n/a	n/a	n/a	n/a
University of Manchester Curated by ChEMBL					Assay Description Inhibition of N-terminal GST fused human RET (658 to 1114 amino acid residue) using CSKtide as substrate expressed in baculovirus preincubated for 15...				Bioorg Med Chem Lett 26: 2724-9 (2016) Article DOI: 10.1016/j.bmcl.2016.03.100 BindingDB Entry DOI: 10.7270/Q2WM1G93
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret (Homo sapiens (Human))	BDBM50165975 (CHEMBL3799933) Show SMILES COc1cc2c(Nc3c(F)ccc(O)c3C)ncnc2cc1OCCCN1CCOCC1 Show InChI InChI=1S/C23H27FN4O4/c1-15-19(29)5-4-17(24)22(15)27-23-16-12-20(30-2)21(13-18(16)25-14-26-23)32-9-3-6-28-7-10-31-11-8-28/h4-5,12-14,29H,3,6-11H2,1-2H3,(H,25,26,27)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	11	n/a	n/a	n/a	n/a	n/a	n/a
University of Manchester Curated by ChEMBL					Assay Description Inhibition of N-terminal GST fused human RET (658 to 1114 amino acid residue) using CSKtide as substrate expressed in baculovirus preincubated for 15...				Bioorg Med Chem Lett 26: 2724-9 (2016) Article DOI: 10.1016/j.bmcl.2016.03.100 BindingDB Entry DOI: 10.7270/Q2WM1G93
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret (Homo sapiens (Human))	BDBM50165898 (CHEMBL3800346) Show SMILES COc1cc2c(Nc3c(C)c(O)ccc3F)ncnc2cc1OCc1cccnc1 Show InChI InChI=1S/C22H19FN4O3/c1-13-18(28)6-5-16(23)21(13)27-22-15-8-19(29-2)20(9-17(15)25-12-26-22)30-11-14-4-3-7-24-10-14/h3-10,12,28H,11H2,1-2H3,(H,25,26,27)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	12	n/a	n/a	n/a	n/a	n/a	n/a
University of Manchester Curated by ChEMBL					Assay Description Inhibition of N-terminal GST fused human RET (658 to 1114 amino acid residue) using CSKtide as substrate expressed in baculovirus preincubated for 15...				Bioorg Med Chem Lett 26: 2724-9 (2016) Article DOI: 10.1016/j.bmcl.2016.03.100 BindingDB Entry DOI: 10.7270/Q2WM1G93
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret (Homo sapiens (Human))	BDBM50165976 (CHEMBL3797561) Show SMILES COc1cc2c(Nc3c(F)ccc(O)c3C)ncnc2cc1OCCN1CCS(=O)(=O)CC1 Show InChI InChI=1S/C22H25FN4O5S/c1-14-18(28)4-3-16(23)21(14)26-22-15-11-19(31-2)20(12-17(15)24-13-25-22)32-8-5-27-6-9-33(29,30)10-7-27/h3-4,11-13,28H,5-10H2,1-2H3,(H,24,25,26)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	14	n/a	n/a	n/a	n/a	n/a	n/a
University of Manchester Curated by ChEMBL					Assay Description Inhibition of N-terminal GST fused human RET (658 to 1114 amino acid residue) using CSKtide as substrate expressed in baculovirus preincubated for 15...				Bioorg Med Chem Lett 26: 2724-9 (2016) Article DOI: 10.1016/j.bmcl.2016.03.100 BindingDB Entry DOI: 10.7270/Q2WM1G93
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret (Homo sapiens (Human))	BDBM50165974 (CHEMBL3797688) Show SMILES COc1cc2c(Nc3c(F)ccc(O)c3C)ncnc2cc1OCCN1CCOCC1 Show InChI InChI=1S/C22H25FN4O4/c1-14-18(28)4-3-16(23)21(14)26-22-15-11-19(29-2)20(12-17(15)24-13-25-22)31-10-7-27-5-8-30-9-6-27/h3-4,11-13,28H,5-10H2,1-2H3,(H,24,25,26)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	14	n/a	n/a	n/a	n/a	n/a	n/a
University of Manchester Curated by ChEMBL					Assay Description Inhibition of N-terminal GST fused human RET (658 to 1114 amino acid residue) using CSKtide as substrate expressed in baculovirus preincubated for 15...				Bioorg Med Chem Lett 26: 2724-9 (2016) Article DOI: 10.1016/j.bmcl.2016.03.100 BindingDB Entry DOI: 10.7270/Q2WM1G93
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret (Homo sapiens (Human))	BDBM50165912 (CHEMBL3797413) Show SMILES COCCOc1cc2ncnc(Nc3c(C)c(O)ccc3F)c2cc1OC Show InChI InChI=1S/C19H20FN3O4/c1-11-15(24)5-4-13(20)18(11)23-19-12-8-16(26-3)17(27-7-6-25-2)9-14(12)21-10-22-19/h4-5,8-10,24H,6-7H2,1-3H3,(H,21,22,23)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	14	n/a	n/a	n/a	n/a	n/a	n/a
University of Manchester Curated by ChEMBL					Assay Description Inhibition of N-terminal GST fused human RET (658 to 1114 amino acid residue) using CSKtide as substrate expressed in baculovirus preincubated for 15...				Bioorg Med Chem Lett 26: 2724-9 (2016) Article DOI: 10.1016/j.bmcl.2016.03.100 BindingDB Entry DOI: 10.7270/Q2WM1G93
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret (Homo sapiens (Human))	BDBM50165942 (CHEMBL3800542) Show SMILES COc1cc2c(Nc3c(F)ccc(O)c3C)ncnc2cc1OCCCN1CCCC1 Show InChI InChI=1S/C23H27FN4O3/c1-15-19(29)7-6-17(24)22(15)27-23-16-12-20(30-2)21(13-18(16)25-14-26-23)31-11-5-10-28-8-3-4-9-28/h6-7,12-14,29H,3-5,8-11H2,1-2H3,(H,25,26,27)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	15	n/a	n/a	n/a	n/a	n/a	n/a
University of Manchester Curated by ChEMBL					Assay Description Inhibition of N-terminal GST fused human RET (658 to 1114 amino acid residue) using CSKtide as substrate expressed in baculovirus preincubated for 15...				Bioorg Med Chem Lett 26: 2724-9 (2016) Article DOI: 10.1016/j.bmcl.2016.03.100 BindingDB Entry DOI: 10.7270/Q2WM1G93
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret (Homo sapiens (Human))	BDBM50165964 (CHEMBL3799244) Show SMILES COc1cc2c(Nc3c(F)ccc(O)c3C)ncnc2cc1OCCCN1CCCCC1 Show InChI InChI=1S/C24H29FN4O3/c1-16-20(30)8-7-18(25)23(16)28-24-17-13-21(31-2)22(14-19(17)26-15-27-24)32-12-6-11-29-9-4-3-5-10-29/h7-8,13-15,30H,3-6,9-12H2,1-2H3,(H,26,27,28)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	15	n/a	n/a	n/a	n/a	n/a	n/a
University of Manchester Curated by ChEMBL					Assay Description Inhibition of N-terminal GST fused human RET (658 to 1114 amino acid residue) using CSKtide as substrate expressed in baculovirus preincubated for 15...				Bioorg Med Chem Lett 26: 2724-9 (2016) Article DOI: 10.1016/j.bmcl.2016.03.100 BindingDB Entry DOI: 10.7270/Q2WM1G93
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret (Homo sapiens (Human))	BDBM50165965 (CHEMBL3798033) Show SMILES COc1cc2c(Nc3c(F)ccc(O)c3C)ncnc2cc1OCCN1CCNCC1 Show InChI InChI=1S/C22H26FN5O3/c1-14-18(29)4-3-16(23)21(14)27-22-15-11-19(30-2)20(12-17(15)25-13-26-22)31-10-9-28-7-5-24-6-8-28/h3-4,11-13,24,29H,5-10H2,1-2H3,(H,25,26,27)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	17	n/a	n/a	n/a	n/a	n/a	n/a
University of Manchester Curated by ChEMBL					Assay Description Inhibition of N-terminal GST fused human RET (658 to 1114 amino acid residue) using CSKtide as substrate expressed in baculovirus preincubated for 15...				Bioorg Med Chem Lett 26: 2724-9 (2016) Article DOI: 10.1016/j.bmcl.2016.03.100 BindingDB Entry DOI: 10.7270/Q2WM1G93
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret (Homo sapiens (Human))	BDBM50165911 (CHEMBL3800155) Show SMILES COc1cc2c(Nc3c(F)ccc(O)c3C)ncnc2cc1OCC1CCCO1 Show InChI InChI=1S/C21H22FN3O4/c1-12-17(26)6-5-15(22)20(12)25-21-14-8-18(27-2)19(9-16(14)23-11-24-21)29-10-13-4-3-7-28-13/h5-6,8-9,11,13,26H,3-4,7,10H2,1-2H3,(H,23,24,25)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	18	n/a	n/a	n/a	n/a	n/a	n/a
University of Manchester Curated by ChEMBL					Assay Description Inhibition of N-terminal GST fused human RET (658 to 1114 amino acid residue) using CSKtide as substrate expressed in baculovirus preincubated for 15...				Bioorg Med Chem Lett 26: 2724-9 (2016) Article DOI: 10.1016/j.bmcl.2016.03.100 BindingDB Entry DOI: 10.7270/Q2WM1G93
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret (Homo sapiens (Human))	BDBM50511674 (CHEMBL4561280) Show SMILES CN(C)CCCNc1ccn2ncc(-c3ccc4OCOc4c3)c2n1 Show InChI InChI=1S/C18H21N5O2/c1-22(2)8-3-7-19-17-6-9-23-18(21-17)14(11-20-23)13-4-5-15-16(10-13)25-12-24-15/h4-6,9-11H,3,7-8,12H2,1-2H3,(H,19,21)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem	PDB Article PubMed	n/a	n/a	19	n/a	n/a	n/a	n/a	n/a	n/a
University of Manchester Curated by ChEMBL					Assay Description Inhibition of recombinant N-Terminal GST-tagged human RET V804M mutant (658 to end residues) incubated for 15 mins followed by substrate addition and...				ACS Med Chem Lett 11: 497-505 (2020) Article DOI: 10.1021/acsmedchemlett.9b00615 BindingDB Entry DOI: 10.7270/Q2154MCJ
					More data for this Ligand-Target Pair				3D Structure (crystal)
Proto-oncogene tyrosine-protein kinase receptor Ret (Homo sapiens (Human))	BDBM50511675 (CHEMBL4534366) Show SMILES NC(=O)c1ccc(cc1)-c1cnn2ccc(NCc3ccncc3)nc12 Show InChI InChI=1S/C19H16N6O/c20-18(26)15-3-1-14(2-4-15)16-12-23-25-10-7-17(24-19(16)25)22-11-13-5-8-21-9-6-13/h1-10,12H,11H2,(H2,20,26)(H,22,24)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	MCE PC cid PC sid UniChem	Article PubMed	n/a	n/a	20	n/a	n/a	n/a	n/a	n/a	n/a
University of Manchester Curated by ChEMBL					Assay Description Inhibition of recombinant N-Terminal GST-tagged human RET V804M mutant (658 to end residues) incubated for 15 mins followed by substrate addition and...				ACS Med Chem Lett 11: 497-505 (2020) Article DOI: 10.1021/acsmedchemlett.9b00615 BindingDB Entry DOI: 10.7270/Q2154MCJ
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret (Homo sapiens (Human))	BDBM50165920 (CHEMBL3799756) Show SMILES CNCCCOc1cc2ncnc(Nc3c(C)c(O)ccc3F)c2cc1OC Show InChI InChI=1S/C20H23FN4O3/c1-12-16(26)6-5-14(21)19(12)25-20-13-9-17(27-3)18(28-8-4-7-22-2)10-15(13)23-11-24-20/h5-6,9-11,22,26H,4,7-8H2,1-3H3,(H,23,24,25)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	23	n/a	n/a	n/a	n/a	n/a	n/a
University of Manchester Curated by ChEMBL					Assay Description Inhibition of N-terminal GST fused human RET (658 to 1114 amino acid residue) using CSKtide as substrate expressed in baculovirus preincubated for 15...				Bioorg Med Chem Lett 26: 2724-9 (2016) Article DOI: 10.1016/j.bmcl.2016.03.100 BindingDB Entry DOI: 10.7270/Q2WM1G93
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret (Homo sapiens (Human))	BDBM50165909 (CHEMBL3798119) Show SMILES COc1cc2c(Nc3c(F)ccc(O)c3C)ncnc2cc1OCc1noc(C)n1 Show InChI InChI=1S/C20H18FN5O4/c1-10-15(27)5-4-13(21)19(10)25-20-12-6-16(28-3)17(7-14(12)22-9-23-20)29-8-18-24-11(2)30-26-18/h4-7,9,27H,8H2,1-3H3,(H,22,23,25)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	24	n/a	n/a	n/a	n/a	n/a	n/a
University of Manchester Curated by ChEMBL					Assay Description Inhibition of N-terminal GST fused human RET (658 to 1114 amino acid residue) using CSKtide as substrate expressed in baculovirus preincubated for 15...				Bioorg Med Chem Lett 26: 2724-9 (2016) Article DOI: 10.1016/j.bmcl.2016.03.100 BindingDB Entry DOI: 10.7270/Q2WM1G93
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret (Homo sapiens (Human))	BDBM50165972 (CHEMBL3800348) Show SMILES COc1cc2c(Nc3c(F)ccc(O)c3C)ncnc2cc1OCCCN1CCN(C)CC1 Show InChI InChI=1S/C24H30FN5O3/c1-16-20(31)6-5-18(25)23(16)28-24-17-13-21(32-3)22(14-19(17)26-15-27-24)33-12-4-7-30-10-8-29(2)9-11-30/h5-6,13-15,31H,4,7-12H2,1-3H3,(H,26,27,28)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	29	n/a	n/a	n/a	n/a	n/a	n/a
University of Manchester Curated by ChEMBL					Assay Description Inhibition of N-terminal GST fused human RET (658 to 1114 amino acid residue) using CSKtide as substrate expressed in baculovirus preincubated for 15...				Bioorg Med Chem Lett 26: 2724-9 (2016) Article DOI: 10.1016/j.bmcl.2016.03.100 BindingDB Entry DOI: 10.7270/Q2WM1G93
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret (Homo sapiens (Human))	BDBM50165895 (CHEMBL3800250) Show SMILES COc1cc2c(Nc3c(F)ccc(O)c3C)ncnc2cc1OCCN1CCC(F)C1 Show InChI InChI=1S/C22H24F2N4O3/c1-13-18(29)4-3-16(24)21(13)27-22-15-9-19(30-2)20(10-17(15)25-12-26-22)31-8-7-28-6-5-14(23)11-28/h3-4,9-10,12,14,29H,5-8,11H2,1-2H3,(H,25,26,27)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	30	n/a	n/a	n/a	n/a	n/a	n/a
University of Manchester Curated by ChEMBL					Assay Description Inhibition of N-terminal GST fused human RET (658 to 1114 amino acid residue) using CSKtide as substrate expressed in baculovirus preincubated for 15...				Bioorg Med Chem Lett 26: 2724-9 (2016) Article DOI: 10.1016/j.bmcl.2016.03.100 BindingDB Entry DOI: 10.7270/Q2WM1G93
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret (Homo sapiens (Human))	BDBM50165913 (CHEMBL3797684) Show SMILES COCCCOc1cc2ncnc(Nc3c(C)c(O)ccc3F)c2cc1OC Show InChI InChI=1S/C20H22FN3O4/c1-12-16(25)6-5-14(21)19(12)24-20-13-9-17(27-3)18(28-8-4-7-26-2)10-15(13)22-11-23-20/h5-6,9-11,25H,4,7-8H2,1-3H3,(H,22,23,24)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	38	n/a	n/a	n/a	n/a	n/a	n/a
University of Manchester Curated by ChEMBL					Assay Description Inhibition of N-terminal GST fused human RET (658 to 1114 amino acid residue) using CSKtide as substrate expressed in baculovirus preincubated for 15...				Bioorg Med Chem Lett 26: 2724-9 (2016) Article DOI: 10.1016/j.bmcl.2016.03.100 BindingDB Entry DOI: 10.7270/Q2WM1G93
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret (Homo sapiens (Human))	BDBM50511682 (CHEMBL4458622) Show SMILES C(Nc1ccn2ncc(-c3ccc4OCOc4c3)c2n1)c1ccccn1 Show InChI InChI=1S/C19H15N5O2/c1-2-7-20-14(3-1)10-21-18-6-8-24-19(23-18)15(11-22-24)13-4-5-16-17(9-13)26-12-25-16/h1-9,11H,10,12H2,(H,21,23)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	39	n/a	n/a	n/a	n/a	n/a	n/a
University of Manchester Curated by ChEMBL					Assay Description Inhibition of recombinant N-Terminal GST-tagged human RET V804M mutant (658 to end residues) incubated for 15 mins followed by substrate addition and...				ACS Med Chem Lett 11: 497-505 (2020) Article DOI: 10.1021/acsmedchemlett.9b00615 BindingDB Entry DOI: 10.7270/Q2154MCJ
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret (Homo sapiens (Human))	BDBM50511686 (CHEMBL4468733) Show SMILES NC(=O)c1ccc(cc1)-c1cnn2ccc(NCc3ccccn3)nc12 Show InChI InChI=1S/C19H16N6O/c20-18(26)14-6-4-13(5-7-14)16-12-23-25-10-8-17(24-19(16)25)22-11-15-3-1-2-9-21-15/h1-10,12H,11H2,(H2,20,26)(H,22,24)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	44	n/a	n/a	n/a	n/a	n/a	n/a
University of Manchester Curated by ChEMBL					Assay Description Inhibition of recombinant N-Terminal GST-tagged human RET V804M mutant (658 to end residues) incubated for 15 mins followed by substrate addition and...				ACS Med Chem Lett 11: 497-505 (2020) Article DOI: 10.1021/acsmedchemlett.9b00615 BindingDB Entry DOI: 10.7270/Q2154MCJ
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret (Homo sapiens (Human))	BDBM50165971 (CHEMBL3798442) Show SMILES COc1cc2c(Nc3c(F)ccc(O)c3C)ncnc2cc1OCCN1CCN(C)CC1 Show InChI InChI=1S/C23H28FN5O3/c1-15-19(30)5-4-17(24)22(15)27-23-16-12-20(31-3)21(13-18(16)25-14-26-23)32-11-10-29-8-6-28(2)7-9-29/h4-5,12-14,30H,6-11H2,1-3H3,(H,25,26,27)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	44	n/a	n/a	n/a	n/a	n/a	n/a
University of Manchester Curated by ChEMBL					Assay Description Inhibition of N-terminal GST fused human RET (658 to 1114 amino acid residue) using CSKtide as substrate expressed in baculovirus preincubated for 15...				Bioorg Med Chem Lett 26: 2724-9 (2016) Article DOI: 10.1016/j.bmcl.2016.03.100 BindingDB Entry DOI: 10.7270/Q2WM1G93
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret (Homo sapiens (Human))	BDBM50153899 (CHEMBL3775940) Show SMILES COc1cc2ncnc(Nc3c(C)c(O)ccc3F)c2cc1OC Show InChI InChI=1S/C17H16FN3O3/c1-9-13(22)5-4-11(18)16(9)21-17-10-6-14(23-2)15(24-3)7-12(10)19-8-20-17/h4-8,22H,1-3H3,(H,19,20,21)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	44	n/a	n/a	n/a	n/a	n/a	n/a
University of Manchester Curated by ChEMBL					Assay Description Inhibition of N-terminal GST fused human RET (658 to 1114 amino acid residue) using CSKtide as substrate expressed in baculovirus preincubated for 15...				Bioorg Med Chem Lett 26: 2724-9 (2016) Article DOI: 10.1016/j.bmcl.2016.03.100 BindingDB Entry DOI: 10.7270/Q2WM1G93
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret (Homo sapiens (Human))	BDBM50165918 (CHEMBL3798215) Show SMILES COc1cc2c(Nc3c(C)c(O)ccc3F)ncnc2cc1OCCCN Show InChI InChI=1S/C19H21FN4O3/c1-11-15(25)5-4-13(20)18(11)24-19-12-8-16(26-2)17(27-7-3-6-21)9-14(12)22-10-23-19/h4-5,8-10,25H,3,6-7,21H2,1-2H3,(H,22,23,24)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	48	n/a	n/a	n/a	n/a	n/a	n/a
University of Manchester Curated by ChEMBL					Assay Description Inhibition of N-terminal GST fused human RET (658 to 1114 amino acid residue) using CSKtide as substrate expressed in baculovirus preincubated for 15...				Bioorg Med Chem Lett 26: 2724-9 (2016) Article DOI: 10.1016/j.bmcl.2016.03.100 BindingDB Entry DOI: 10.7270/Q2WM1G93
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret (Homo sapiens (Human))	BDBM50511673 (CHEMBL4570029) Show SMILES NC(=O)c1ccc(cc1)-c1cnn2ccc(NCc3cccnc3)nc12 Show InChI InChI=1S/C19H16N6O/c20-18(26)15-5-3-14(4-6-15)16-12-23-25-9-7-17(24-19(16)25)22-11-13-2-1-8-21-10-13/h1-10,12H,11H2,(H2,20,26)(H,22,24)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem	PDB Article PubMed	n/a	n/a	51	n/a	n/a	n/a	n/a	n/a	n/a
University of Manchester Curated by ChEMBL					Assay Description Inhibition of recombinant N-Terminal GST-tagged human RET V804M mutant (658 to end residues) incubated for 15 mins followed by substrate addition and...				ACS Med Chem Lett 11: 497-505 (2020) Article DOI: 10.1021/acsmedchemlett.9b00615 BindingDB Entry DOI: 10.7270/Q2154MCJ
					More data for this Ligand-Target Pair				3D Structure (crystal)
Proto-oncogene tyrosine-protein kinase receptor Ret (Homo sapiens (Human))	BDBM50165897 (CHEMBL3798883) Show SMILES COc1cc2c(Nc3c(F)ccc(O)c3C)ncnc2cc1OCCCN1CCCC1C(F)(F)F Show InChI InChI=1S/C24H26F4N4O3/c1-14-18(33)7-6-16(25)22(14)31-23-15-11-19(34-2)20(12-17(15)29-13-30-23)35-10-4-9-32-8-3-5-21(32)24(26,27)28/h6-7,11-13,21,33H,3-5,8-10H2,1-2H3,(H,29,30,31)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	62	n/a	n/a	n/a	n/a	n/a	n/a
University of Manchester Curated by ChEMBL					Assay Description Inhibition of N-terminal GST fused human RET (658 to 1114 amino acid residue) using CSKtide as substrate expressed in baculovirus preincubated for 15...				Bioorg Med Chem Lett 26: 2724-9 (2016) Article DOI: 10.1016/j.bmcl.2016.03.100 BindingDB Entry DOI: 10.7270/Q2WM1G93
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret (Homo sapiens (Human))	BDBM50165969 (CHEMBL3799969) Show SMILES COc1cc2c(Nc3c(F)ccc(O)c3C)ncnc2cc1OCCN1CCCNCC1 Show InChI InChI=1S/C23H28FN5O3/c1-15-19(30)5-4-17(24)22(15)28-23-16-12-20(31-2)21(13-18(16)26-14-27-23)32-11-10-29-8-3-6-25-7-9-29/h4-5,12-14,25,30H,3,6-11H2,1-2H3,(H,26,27,28)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	65	n/a	n/a	n/a	n/a	n/a	n/a
University of Manchester Curated by ChEMBL					Assay Description Inhibition of N-terminal GST fused human RET (658 to 1114 amino acid residue) using CSKtide as substrate expressed in baculovirus preincubated for 15...				Bioorg Med Chem Lett 26: 2724-9 (2016) Article DOI: 10.1016/j.bmcl.2016.03.100 BindingDB Entry DOI: 10.7270/Q2WM1G93
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret (Homo sapiens (Human))	BDBM50165910 (CHEMBL3799843) Show SMILES COc1cc2c(Nc3c(F)ccc(O)c3C)ncnc2cc1OCC1CCN(C)CC1 Show InChI InChI=1S/C23H27FN4O3/c1-14-19(29)5-4-17(24)22(14)27-23-16-10-20(30-3)21(11-18(16)25-13-26-23)31-12-15-6-8-28(2)9-7-15/h4-5,10-11,13,15,29H,6-9,12H2,1-3H3,(H,25,26,27)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	78	n/a	n/a	n/a	n/a	n/a	n/a
University of Manchester Curated by ChEMBL					Assay Description Inhibition of N-terminal GST fused human RET (658 to 1114 amino acid residue) using CSKtide as substrate expressed in baculovirus preincubated for 15...				Bioorg Med Chem Lett 26: 2724-9 (2016) Article DOI: 10.1016/j.bmcl.2016.03.100 BindingDB Entry DOI: 10.7270/Q2WM1G93
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret (Homo sapiens (Human))	BDBM50511691 (CHEMBL4536873) Show SMILES CN(C)CCNc1ccn2ncc(-c3ccc4OCOc4c3)c2n1 Show InChI InChI=1S/C17H19N5O2/c1-21(2)8-6-18-16-5-7-22-17(20-16)13(10-19-22)12-3-4-14-15(9-12)24-11-23-14/h3-5,7,9-10H,6,8,11H2,1-2H3,(H,18,20)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	91	n/a	n/a	n/a	n/a	n/a	n/a
University of Manchester Curated by ChEMBL					Assay Description Inhibition of recombinant N-Terminal GST-tagged human RET V804M mutant (658 to end residues) incubated for 15 mins followed by substrate addition and...				ACS Med Chem Lett 11: 497-505 (2020) Article DOI: 10.1021/acsmedchemlett.9b00615 BindingDB Entry DOI: 10.7270/Q2154MCJ
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret (Homo sapiens (Human))	BDBM50165923 (CHEMBL3797895) Show SMILES COc1cc2c(Nc3c(F)ccc(O)c3C)ncnc2cc1OCCN1CCCC1 Show InChI InChI=1S/C22H25FN4O3/c1-14-18(28)6-5-16(23)21(14)26-22-15-11-19(29-2)20(12-17(15)24-13-25-22)30-10-9-27-7-3-4-8-27/h5-6,11-13,28H,3-4,7-10H2,1-2H3,(H,24,25,26)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	100	n/a	n/a	n/a	n/a	n/a	n/a
University of Manchester Curated by ChEMBL					Assay Description Inhibition of N-terminal GST fused human RET (658 to 1114 amino acid residue) using CSKtide as substrate expressed in baculovirus preincubated for 15...				Bioorg Med Chem Lett 26: 2724-9 (2016) Article DOI: 10.1016/j.bmcl.2016.03.100 BindingDB Entry DOI: 10.7270/Q2WM1G93
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret (Homo sapiens (Human))	BDBM50165919 (CHEMBL3800408) Show SMILES CNCCOc1cc2ncnc(Nc3c(C)c(O)ccc3F)c2cc1OC Show InChI InChI=1S/C19H21FN4O3/c1-11-15(25)5-4-13(20)18(11)24-19-12-8-16(26-3)17(27-7-6-21-2)9-14(12)22-10-23-19/h4-5,8-10,21,25H,6-7H2,1-3H3,(H,22,23,24)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	100	n/a	n/a	n/a	n/a	n/a	n/a
University of Manchester Curated by ChEMBL					Assay Description Inhibition of N-terminal GST fused human RET (658 to 1114 amino acid residue) using CSKtide as substrate expressed in baculovirus preincubated for 15...				Bioorg Med Chem Lett 26: 2724-9 (2016) Article DOI: 10.1016/j.bmcl.2016.03.100 BindingDB Entry DOI: 10.7270/Q2WM1G93
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret (Homo sapiens (Human))	BDBM50511674 (CHEMBL4561280) Show SMILES CN(C)CCCNc1ccn2ncc(-c3ccc4OCOc4c3)c2n1 Show InChI InChI=1S/C18H21N5O2/c1-22(2)8-3-7-19-17-6-9-23-18(21-17)14(11-20-23)13-4-5-15-16(10-13)25-12-24-15/h4-6,9-11H,3,7-8,12H2,1-2H3,(H,19,21)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem	PDB Article PubMed	n/a	n/a	110	n/a	n/a	n/a	n/a	n/a	n/a
University of Manchester Curated by ChEMBL					Assay Description Inhibition of RET V804M mutant (unknown origin)expressed in human BaF3 cells assessed as reduction in cell viability incubated for 48 hrs by celltite...				ACS Med Chem Lett 11: 497-505 (2020) Article DOI: 10.1021/acsmedchemlett.9b00615 BindingDB Entry DOI: 10.7270/Q2154MCJ
					More data for this Ligand-Target Pair				3D Structure (crystal)
Proto-oncogene tyrosine-protein kinase receptor Ret (Homo sapiens (Human))	BDBM50165908 (CHEMBL3797991) Show SMILES COc1cc2c(Nc3c(F)ccc(O)c3C)ncnc2cc1OCc1nccn1C Show InChI InChI=1S/C21H20FN5O3/c1-12-16(28)5-4-14(22)20(12)26-21-13-8-17(29-3)18(9-15(13)24-11-25-21)30-10-19-23-6-7-27(19)2/h4-9,11,28H,10H2,1-3H3,(H,24,25,26)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	110	n/a	n/a	n/a	n/a	n/a	n/a
University of Manchester Curated by ChEMBL					Assay Description Inhibition of N-terminal GST fused human RET (658 to 1114 amino acid residue) using CSKtide as substrate expressed in baculovirus preincubated for 15...				Bioorg Med Chem Lett 26: 2724-9 (2016) Article DOI: 10.1016/j.bmcl.2016.03.100 BindingDB Entry DOI: 10.7270/Q2WM1G93
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret (Homo sapiens (Human))	BDBM50165963 (CHEMBL3799867) Show SMILES COc1cc2c(Nc3c(F)ccc(O)c3C)ncnc2cc1OCCN1CCCCC1 Show InChI InChI=1S/C23H27FN4O3/c1-15-19(29)7-6-17(24)22(15)27-23-16-12-20(30-2)21(13-18(16)25-14-26-23)31-11-10-28-8-4-3-5-9-28/h6-7,12-14,29H,3-5,8-11H2,1-2H3,(H,25,26,27)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	120	n/a	n/a	n/a	n/a	n/a	n/a
University of Manchester Curated by ChEMBL					Assay Description Inhibition of N-terminal GST fused human RET (658 to 1114 amino acid residue) using CSKtide as substrate expressed in baculovirus preincubated for 15...				Bioorg Med Chem Lett 26: 2724-9 (2016) Article DOI: 10.1016/j.bmcl.2016.03.100 BindingDB Entry DOI: 10.7270/Q2WM1G93
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret (Homo sapiens (Human))	BDBM50511685 (CHEMBL4466600) Show SMILES OCCNc1ccn2ncc(-c3ccc4OCOc4c3)c2n1 Show InChI InChI=1S/C15H14N4O3/c20-6-4-16-14-3-5-19-15(18-14)11(8-17-19)10-1-2-12-13(7-10)22-9-21-12/h1-3,5,7-8,20H,4,6,9H2,(H,16,18)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	130	n/a	n/a	n/a	n/a	n/a	n/a
University of Manchester Curated by ChEMBL					Assay Description Inhibition of recombinant N-Terminal GST-tagged human RET V804M mutant (658 to end residues) incubated for 15 mins followed by substrate addition and...				ACS Med Chem Lett 11: 497-505 (2020) Article DOI: 10.1021/acsmedchemlett.9b00615 BindingDB Entry DOI: 10.7270/Q2154MCJ
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret (Homo sapiens (Human))	BDBM50165917 (CHEMBL3797288) Show SMILES COc1cc2c(Nc3c(C)c(O)ccc3F)ncnc2cc1OCCN Show InChI InChI=1S/C18H19FN4O3/c1-10-14(24)4-3-12(19)17(10)23-18-11-7-15(25-2)16(26-6-5-20)8-13(11)21-9-22-18/h3-4,7-9,24H,5-6,20H2,1-2H3,(H,21,22,23)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	130	n/a	n/a	n/a	n/a	n/a	n/a
University of Manchester Curated by ChEMBL					Assay Description Inhibition of N-terminal GST fused human RET (658 to 1114 amino acid residue) using CSKtide as substrate expressed in baculovirus preincubated for 15...				Bioorg Med Chem Lett 26: 2724-9 (2016) Article DOI: 10.1016/j.bmcl.2016.03.100 BindingDB Entry DOI: 10.7270/Q2WM1G93
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret (Homo sapiens (Human))	BDBM50165916 (CHEMBL3800327) Show SMILES COc1cc2ncnc(Nc3cccc4[nH]ncc34)c2cc1OC Show InChI InChI=1S/C17H15N5O2/c1-23-15-6-10-14(7-16(15)24-2)18-9-19-17(10)21-12-4-3-5-13-11(12)8-20-22-13/h3-9H,1-2H3,(H,20,22)(H,18,19,21)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	140	n/a	n/a	n/a	n/a	n/a	n/a
University of Manchester Curated by ChEMBL					Assay Description Inhibition of N-terminal GST fused human RET (658 to 1114 amino acid residue) using CSKtide as substrate expressed in baculovirus preincubated for 15...				Bioorg Med Chem Lett 26: 2724-9 (2016) Article DOI: 10.1016/j.bmcl.2016.03.100 BindingDB Entry DOI: 10.7270/Q2WM1G93
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret (Homo sapiens (Human))	BDBM50165896 (CHEMBL3798349) Show SMILES COc1cc2c(Nc3c(F)ccc(O)c3C)ncnc2cc1OCCN1CCCC1C(F)(F)F Show InChI InChI=1S/C23H24F4N4O3/c1-13-17(32)6-5-15(24)21(13)30-22-14-10-18(33-2)19(11-16(14)28-12-29-22)34-9-8-31-7-3-4-20(31)23(25,26)27/h5-6,10-12,20,32H,3-4,7-9H2,1-2H3,(H,28,29,30)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	150	n/a	n/a	n/a	n/a	n/a	n/a
University of Manchester Curated by ChEMBL					Assay Description Inhibition of N-terminal GST fused human RET (658 to 1114 amino acid residue) using CSKtide as substrate expressed in baculovirus preincubated for 15...				Bioorg Med Chem Lett 26: 2724-9 (2016) Article DOI: 10.1016/j.bmcl.2016.03.100 BindingDB Entry DOI: 10.7270/Q2WM1G93
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret (Homo sapiens (Human))	BDBM50021574 (BMS-907351 | CABOZANTINIB | CHEBI:72317 | Cabomety...) Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)C4(CC4)C(=O)Nc4ccc(F)cc4)cc3)c2cc1OC Show InChI InChI=1S/C28H24FN3O5/c1-35-24-15-21-22(16-25(24)36-2)30-14-11-23(21)37-20-9-7-19(8-10-20)32-27(34)28(12-13-28)26(33)31-18-5-3-17(29)4-6-18/h3-11,14-16H,12-13H2,1-2H3,(H,31,33)(H,32,34)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	180	n/a	n/a	n/a	n/a	n/a	n/a
University of Manchester Curated by ChEMBL					Assay Description Inhibition of RET V804M mutant (unknown origin)expressed in human BaF3 cells assessed as reduction in cell viability incubated for 48 hrs by celltite...				ACS Med Chem Lett 11: 497-505 (2020) Article DOI: 10.1021/acsmedchemlett.9b00615 BindingDB Entry DOI: 10.7270/Q2154MCJ
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret (Homo sapiens (Human))	BDBM50511683 (CHEMBL4532182) Show SMILES C(Nc1ccn2ncc(-c3ccc4OCOc4c3)c2n1)C1CCNCC1 Show InChI InChI=1S/C19H21N5O2/c1-2-16-17(26-12-25-16)9-14(1)15-11-22-24-8-5-18(23-19(15)24)21-10-13-3-6-20-7-4-13/h1-2,5,8-9,11,13,20H,3-4,6-7,10,12H2,(H,21,23)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	200	n/a	n/a	n/a	n/a	n/a	n/a
University of Manchester Curated by ChEMBL					Assay Description Inhibition of recombinant N-Terminal GST-tagged human RET V804M mutant (658 to end residues) incubated for 15 mins followed by substrate addition and...				ACS Med Chem Lett 11: 497-505 (2020) Article DOI: 10.1021/acsmedchemlett.9b00615 BindingDB Entry DOI: 10.7270/Q2154MCJ
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret (Homo sapiens (Human))	BDBM50165914 (CHEMBL3800021) Show SMILES COc1cc2ncnc(Nc3ccc4cn[nH]c4c3)c2cc1OC Show InChI InChI=1S/C17H15N5O2/c1-23-15-6-12-14(7-16(15)24-2)18-9-19-17(12)21-11-4-3-10-8-20-22-13(10)5-11/h3-9H,1-2H3,(H,20,22)(H,18,19,21)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	280	n/a	n/a	n/a	n/a	n/a	n/a
University of Manchester Curated by ChEMBL					Assay Description Inhibition of N-terminal GST fused human RET (658 to 1114 amino acid residue) using CSKtide as substrate expressed in baculovirus preincubated for 15...				Bioorg Med Chem Lett 26: 2724-9 (2016) Article DOI: 10.1016/j.bmcl.2016.03.100 BindingDB Entry DOI: 10.7270/Q2WM1G93
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret (Homo sapiens (Human))	BDBM50511687 (CHEMBL4547553) Show SMILES C(Nc1ccn2ncc(-c3ccc4OCOc4c3)c2n1)c1ccncc1 Show InChI InChI=1S/C19H15N5O2/c1-2-16-17(26-12-25-16)9-14(1)15-11-22-24-8-5-18(23-19(15)24)21-10-13-3-6-20-7-4-13/h1-9,11H,10,12H2,(H,21,23)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	290	n/a	n/a	n/a	n/a	n/a	n/a
University of Manchester Curated by ChEMBL					Assay Description Inhibition of recombinant N-Terminal GST-tagged human RET V804M mutant (658 to end residues) incubated for 15 mins followed by substrate addition and...				ACS Med Chem Lett 11: 497-505 (2020) Article DOI: 10.1021/acsmedchemlett.9b00615 BindingDB Entry DOI: 10.7270/Q2154MCJ
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret (Homo sapiens (Human))	BDBM50511672 (CHEMBL4513446) Show SMILES C(Nc1ccn2ncc(-c3ccc4cn[nH]c4c3)c2n1)c1ccncc1 Show InChI InChI=1S/C19H15N7/c1-2-15-11-22-25-17(15)9-14(1)16-12-23-26-8-5-18(24-19(16)26)21-10-13-3-6-20-7-4-13/h1-9,11-12H,10H2,(H,21,24)(H,22,25)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	300	n/a	n/a	n/a	n/a	n/a	n/a
University of Manchester Curated by ChEMBL					Assay Description Inhibition of recombinant N-Terminal GST-tagged human RET V804M mutant (658 to end residues) incubated for 15 mins followed by substrate addition and...				ACS Med Chem Lett 11: 497-505 (2020) Article DOI: 10.1021/acsmedchemlett.9b00615 BindingDB Entry DOI: 10.7270/Q2154MCJ
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret (Homo sapiens (Human))	BDBM50165921 (CHEMBL3799264) Show SMILES COc1cc2c(Nc3c(F)ccc(O)c3C)ncnc2cc1OCCN(C)C Show InChI InChI=1S/C20H23FN4O3/c1-12-16(26)6-5-14(21)19(12)24-20-13-9-17(27-4)18(28-8-7-25(2)3)10-15(13)22-11-23-20/h5-6,9-11,26H,7-8H2,1-4H3,(H,22,23,24)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	350	n/a	n/a	n/a	n/a	n/a	n/a
University of Manchester Curated by ChEMBL					Assay Description Inhibition of N-terminal GST fused human RET (658 to 1114 amino acid residue) using CSKtide as substrate expressed in baculovirus preincubated for 15...				Bioorg Med Chem Lett 26: 2724-9 (2016) Article DOI: 10.1016/j.bmcl.2016.03.100 BindingDB Entry DOI: 10.7270/Q2WM1G93
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret (Homo sapiens (Human))	BDBM50511677 (CHEMBL4457706) Show SMILES CN(C)CCNc1ccn2ncc(-c3ccc(cc3)C(N)=O)c2n1 Show InChI InChI=1S/C17H20N6O/c1-22(2)10-8-19-15-7-9-23-17(21-15)14(11-20-23)12-3-5-13(6-4-12)16(18)24/h3-7,9,11H,8,10H2,1-2H3,(H2,18,24)(H,19,21)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	350	n/a	n/a	n/a	n/a	n/a	n/a
University of Manchester Curated by ChEMBL					Assay Description Inhibition of recombinant N-Terminal GST-tagged human RET V804M mutant (658 to end residues) incubated for 15 mins followed by substrate addition and...				ACS Med Chem Lett 11: 497-505 (2020) Article DOI: 10.1021/acsmedchemlett.9b00615 BindingDB Entry DOI: 10.7270/Q2154MCJ
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret (Homo sapiens (Human))	BDBM50511678 (CHEMBL4536438) Show SMILES NS(=O)(=O)c1ccc(cc1)-c1cnn2ccc(NCc3ccncc3)nc12 Show InChI InChI=1S/C18H16N6O2S/c19-27(25,26)15-3-1-14(2-4-15)16-12-22-24-10-7-17(23-18(16)24)21-11-13-5-8-20-9-6-13/h1-10,12H,11H2,(H,21,23)(H2,19,25,26)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	360	n/a	n/a	n/a	n/a	n/a	n/a
University of Manchester Curated by ChEMBL					Assay Description Inhibition of recombinant N-Terminal GST-tagged human RET V804M mutant (658 to end residues) incubated for 15 mins followed by substrate addition and...				ACS Med Chem Lett 11: 497-505 (2020) Article DOI: 10.1021/acsmedchemlett.9b00615 BindingDB Entry DOI: 10.7270/Q2154MCJ
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret (Homo sapiens (Human))	BDBM50511679 (CHEMBL4593942) Show SMILES OC(=O)c1ccc(cc1)-c1cnn2ccc(NCc3ccncc3)nc12 Show InChI InChI=1S/C19H15N5O2/c25-19(26)15-3-1-14(2-4-15)16-12-22-24-10-7-17(23-18(16)24)21-11-13-5-8-20-9-6-13/h1-10,12H,11H2,(H,21,23)(H,25,26)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	560	n/a	n/a	n/a	n/a	n/a	n/a
University of Manchester Curated by ChEMBL					Assay Description Inhibition of recombinant N-Terminal GST-tagged human RET V804M mutant (658 to end residues) incubated for 15 mins followed by substrate addition and...				ACS Med Chem Lett 11: 497-505 (2020) Article DOI: 10.1021/acsmedchemlett.9b00615 BindingDB Entry DOI: 10.7270/Q2154MCJ
					More data for this Ligand-Target Pair
Kinesin-1 heavy chain/Proto-oncogene tyrosine-protein kinase receptor Ret (Homo sapiens (Human))	BDBM50165897 (CHEMBL3798883) Show SMILES COc1cc2c(Nc3c(F)ccc(O)c3C)ncnc2cc1OCCCN1CCCC1C(F)(F)F Show InChI InChI=1S/C24H26F4N4O3/c1-14-18(33)7-6-16(25)22(14)31-23-15-11-19(34-2)20(12-17(15)29-13-30-23)35-10-4-9-32-8-3-5-21(32)24(26,27)28/h6-7,11-13,21,33H,3-5,8-10H2,1-2H3,(H,29,30,31)	PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	600	n/a	n/a	n/a	n/a	n/a	n/a
University of Manchester Curated by ChEMBL					Assay Description Inhibition of recombinant KIF5B/RET (unknown origin) expressed in IL3 deficient BAF3 cells assessed as reduction in cell viability after 48 hrs by Ce...				Bioorg Med Chem Lett 26: 2724-9 (2016) Article DOI: 10.1016/j.bmcl.2016.03.100 BindingDB Entry DOI: 10.7270/Q2WM1G93
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret (Homo sapiens (Human))	BDBM50165915 (CHEMBL3798986) Show SMILES COc1cc2ncnc(Nc3ccc4[nH]ncc4c3)c2cc1OC Show InChI InChI=1S/C17H15N5O2/c1-23-15-6-12-14(7-16(15)24-2)18-9-19-17(12)21-11-3-4-13-10(5-11)8-20-22-13/h3-9H,1-2H3,(H,20,22)(H,18,19,21)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	600	n/a	n/a	n/a	n/a	n/a	n/a
University of Manchester Curated by ChEMBL					Assay Description Inhibition of N-terminal GST fused human RET (658 to 1114 amino acid residue) using CSKtide as substrate expressed in baculovirus preincubated for 15...				Bioorg Med Chem Lett 26: 2724-9 (2016) Article DOI: 10.1016/j.bmcl.2016.03.100 BindingDB Entry DOI: 10.7270/Q2WM1G93
					More data for this Ligand-Target Pair

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