Compile Data Set for Download or QSAR

Found 312 hits with Last Name = 'chen' and Initial = 'cj'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM50193995 (3-((3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyr...) Show SMILES C[C@@H]1CCN(C[C@@H]1N(C)c1ncnc2[nH]ccc12)C(=O)CC#N |r| Show InChI InChI=1S/C16H20N6O/c1-11-5-8-22(14(23)3-6-17)9-13(11)21(2)16-12-4-7-18-15(12)19-10-20-16/h4,7,10-11,13H,3,5,8-9H2,1-2H3,(H,18,19,20)/t11-,13+/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	0.5	n/a	n/a	n/a	n/a	n/a	n/a
China Pharmaceutical University Curated by ChEMBL					Assay Description Inhibition of human JAK2 using TK-substrate-biotin preincubated for 5 mins followed by substrate addition and further incubated for 30 mins and subse...				Bioorg Med Chem 27: 1646-1657 (2019) Article DOI: 10.1016/j.bmc.2019.03.009 BindingDB Entry DOI: 10.7270/Q2PC35WG
					More data for this Ligand-Target Pair				3D Structure (crystal)
Tyrosine-protein kinase JAK3 (Homo sapiens (Human))	BDBM50193995 (3-((3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyr...) Show SMILES C[C@@H]1CCN(C[C@@H]1N(C)c1ncnc2[nH]ccc12)C(=O)CC#N |r| Show InChI InChI=1S/C16H20N6O/c1-11-5-8-22(14(23)3-6-17)9-13(11)21(2)16-12-4-7-18-15(12)19-10-20-16/h4,7,10-11,13H,3,5,8-9H2,1-2H3,(H,18,19,20)/t11-,13+/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	0.700	n/a	n/a	n/a	n/a	n/a	n/a
China Pharmaceutical University Curated by ChEMBL					Assay Description Inhibition of human JAK3 using TK-substrate-biotin preincubated for 5 mins followed by substrate addition and further incubated for 30 mins and subse...				Bioorg Med Chem 27: 1646-1657 (2019) Article DOI: 10.1016/j.bmc.2019.03.009 BindingDB Entry DOI: 10.7270/Q2PC35WG
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK3 (Homo sapiens (Human))	BDBM50537422 (CHEMBL4584430) Show SMILES CCC(=O)N1CCC(CC1)c1ccc(Nc2cc(NCc3cccc(c3)-c3ccncc3)c(cn2)C(N)=O)cc1 Show InChI InChI=1S/C32H34N6O2/c1-2-31(39)38-16-12-25(13-17-38)23-6-8-27(9-7-23)37-30-19-29(28(21-36-30)32(33)40)35-20-22-4-3-5-26(18-22)24-10-14-34-15-11-24/h3-11,14-15,18-19,21,25H,2,12-13,16-17,20H2,1H3,(H2,33,40)(H2,35,36,37)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
China Pharmaceutical University Curated by ChEMBL					Assay Description Inhibition of human GST-tagged JAK3 using FITC-KGGEEEEYFELVKK as substrate by fluorescence assay				Bioorg Med Chem 27: 1646-1657 (2019) Article DOI: 10.1016/j.bmc.2019.03.009 BindingDB Entry DOI: 10.7270/Q2PC35WG
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 (Homo sapiens (Human))	BDBM50193995 (3-((3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyr...) Show SMILES C[C@@H]1CCN(C[C@@H]1N(C)c1ncnc2[nH]ccc12)C(=O)CC#N |r| Show InChI InChI=1S/C16H20N6O/c1-11-5-8-22(14(23)3-6-17)9-13(11)21(2)16-12-4-7-18-15(12)19-10-20-16/h4,7,10-11,13H,3,5,8-9H2,1-2H3,(H,18,19,20)/t11-,13+/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	1.40	n/a	n/a	n/a	n/a	n/a	n/a
China Pharmaceutical University Curated by ChEMBL					Assay Description Inhibition of human JAK1 using TK-substrate-biotin preincubated for 5 mins followed by substrate addition and further incubated for 30 mins and subse...				Bioorg Med Chem 27: 1646-1657 (2019) Article DOI: 10.1016/j.bmc.2019.03.009 BindingDB Entry DOI: 10.7270/Q2PC35WG
					More data for this Ligand-Target Pair				3D Structure (crystal)
Tyrosine-protein kinase JAK1 (Homo sapiens (Human))	BDBM50193995 (3-((3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyr...) Show SMILES C[C@@H]1CCN(C[C@@H]1N(C)c1ncnc2[nH]ccc12)C(=O)CC#N |r| Show InChI InChI=1S/C16H20N6O/c1-11-5-8-22(14(23)3-6-17)9-13(11)21(2)16-12-4-7-18-15(12)19-10-20-16/h4,7,10-11,13H,3,5,8-9H2,1-2H3,(H,18,19,20)/t11-,13+/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	1.60	n/a	n/a	n/a	n/a	n/a	n/a
China Pharmaceutical University Curated by ChEMBL					Assay Description Inhibition of recombinant human GST-tagged JAK1 catalytic domain (866 to 1154 residues) expressed in baculovirus expression system using TK-substrate...				Bioorg Med Chem 26: 4774-4786 (2018) Article DOI: 10.1016/j.bmc.2018.04.005 BindingDB Entry DOI: 10.7270/Q26Q20XK
					More data for this Ligand-Target Pair				3D Structure (crystal)
Tyrosine-protein kinase JAK1 (Homo sapiens (Human))	BDBM50193995 (3-((3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyr...) Show SMILES C[C@@H]1CCN(C[C@@H]1N(C)c1ncnc2[nH]ccc12)C(=O)CC#N |r| Show InChI InChI=1S/C16H20N6O/c1-11-5-8-22(14(23)3-6-17)9-13(11)21(2)16-12-4-7-18-15(12)19-10-20-16/h4,7,10-11,13H,3,5,8-9H2,1-2H3,(H,18,19,20)/t11-,13+/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	1.60	n/a	n/a	n/a	n/a	n/a	n/a
China Pharmaceutical University Curated by ChEMBL					Assay Description Inhibition of recombinant human GST-tagged JAK1 catalytic domain (866 to 1154 residues) expressed in baculovirus expression system using TK-biotin as...				Bioorg Med Chem 27: 1562-1576 (2019) Article DOI: 10.1016/j.bmc.2019.02.054 BindingDB Entry DOI: 10.7270/Q2VM4GQ9
					More data for this Ligand-Target Pair				3D Structure (crystal)
Tyrosine-protein kinase JAK3 (Homo sapiens (Human))	BDBM50193995 (3-((3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyr...) Show SMILES C[C@@H]1CCN(C[C@@H]1N(C)c1ncnc2[nH]ccc12)C(=O)CC#N |r| Show InChI InChI=1S/C16H20N6O/c1-11-5-8-22(14(23)3-6-17)9-13(11)21(2)16-12-4-7-18-15(12)19-10-20-16/h4,7,10-11,13H,3,5,8-9H2,1-2H3,(H,18,19,20)/t11-,13+/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	2.10	n/a	n/a	n/a	n/a	n/a	n/a
China Pharmaceutical University Curated by ChEMBL					Assay Description Inhibition of recombinant human GST-tagged JAK3 catalytic domain (781 to 1124 residues) expressed in baculovirus expression system using TK-biotin as...				Bioorg Med Chem 27: 1562-1576 (2019) Article DOI: 10.1016/j.bmc.2019.02.054 BindingDB Entry DOI: 10.7270/Q2VM4GQ9
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK3 (Homo sapiens (Human))	BDBM50193995 (3-((3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyr...) Show SMILES C[C@@H]1CCN(C[C@@H]1N(C)c1ncnc2[nH]ccc12)C(=O)CC#N |r| Show InChI InChI=1S/C16H20N6O/c1-11-5-8-22(14(23)3-6-17)9-13(11)21(2)16-12-4-7-18-15(12)19-10-20-16/h4,7,10-11,13H,3,5,8-9H2,1-2H3,(H,18,19,20)/t11-,13+/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	2.10	n/a	n/a	n/a	n/a	n/a	n/a
China Pharmaceutical University Curated by ChEMBL					Assay Description Inhibition of recombinant human GST-tagged JAK3 catalytic domain expressed in baculovirus expression system using TK-substrate-biotin preincubated fo...				Bioorg Med Chem 26: 4774-4786 (2018) Article DOI: 10.1016/j.bmc.2018.04.005 BindingDB Entry DOI: 10.7270/Q26Q20XK
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK3 (Homo sapiens (Human))	BDBM50109518 (CHEMBL3601722) Show SMILES CN1CCN(CC1)c1ccc(Nc2cc(NCc3cccc(NC(=O)C=C)c3)ncn2)cc1 Show InChI InChI=1S/C25H29N7O/c1-3-25(33)30-21-6-4-5-19(15-21)17-26-23-16-24(28-18-27-23)29-20-7-9-22(10-8-20)32-13-11-31(2)12-14-32/h3-10,15-16,18H,1,11-14,17H2,2H3,(H,30,33)(H2,26,27,28,29)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.10	n/a	n/a	n/a	n/a	n/a	n/a
China Pharmaceutical University Curated by ChEMBL					Assay Description Inhibition of human JAK3 using TK-substrate-biotin preincubated for 5 mins followed by substrate addition and further incubated for 30 mins and subse...				Bioorg Med Chem 27: 1646-1657 (2019) Article DOI: 10.1016/j.bmc.2019.03.009 BindingDB Entry DOI: 10.7270/Q2PC35WG
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK3 (Homo sapiens (Human))	BDBM50537427 (CHEMBL4573218) Show SMILES C=CC(=O)Nc1cccc(CNc2cc(Nc3ccc(cc3)N3CCOCC3)ncn2)c1 Show InChI InChI=1S/C24H26N6O2/c1-2-24(31)29-20-5-3-4-18(14-20)16-25-22-15-23(27-17-26-22)28-19-6-8-21(9-7-19)30-10-12-32-13-11-30/h2-9,14-15,17H,1,10-13,16H2,(H,29,31)(H2,25,26,27,28)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	2.40	n/a	n/a	n/a	n/a	n/a	n/a
China Pharmaceutical University Curated by ChEMBL					Assay Description Inhibition of human JAK3 using TK-substrate-biotin preincubated for 5 mins followed by substrate addition and further incubated for 30 mins and subse...				Bioorg Med Chem 27: 1646-1657 (2019) Article DOI: 10.1016/j.bmc.2019.03.009 BindingDB Entry DOI: 10.7270/Q2PC35WG
					More data for this Ligand-Target Pair
Melanin-concentrating hormone receptor 1 (Homo sapiens (Human))	BDBM50201274 (CHEMBL215661 | N-(1-(6-acetamido-2,3-dihydro-1H-in...) Show SMILES CC(=O)Nc1ccc2CCC(N3CCC(CC3)NC(=O)c3cc(=O)c4ccc(F)cc4o3)c2c1 Show InChI InChI=1S/C26H26FN3O4/c1-15(31)28-19-5-2-16-3-7-22(21(16)13-19)30-10-8-18(9-11-30)29-26(33)25-14-23(32)20-6-4-17(27)12-24(20)34-25/h2,4-6,12-14,18,22H,3,7-11H2,1H3,(H,28,31)(H,29,33)	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Displacement of 125I-MCH from MCH-R1 expressed in IMR-32 cells				Bioorg Med Chem Lett 17: 884-9 (2007) Article DOI: 10.1016/j.bmcl.2006.11.061 BindingDB Entry DOI: 10.7270/Q2J38S6V
					More data for this Ligand-Target Pair
Melanin-concentrating hormone receptor 1 (Homo sapiens (Human))	BDBM50201274 (CHEMBL215661 | N-(1-(6-acetamido-2,3-dihydro-1H-in...) Show SMILES CC(=O)Nc1ccc2CCC(N3CCC(CC3)NC(=O)c3cc(=O)c4ccc(F)cc4o3)c2c1 Show InChI InChI=1S/C26H26FN3O4/c1-15(31)28-19-5-2-16-3-7-22(21(16)13-19)30-10-8-18(9-11-30)29-26(33)25-14-23(32)20-6-4-17(27)12-24(20)34-25/h2,4-6,12-14,18,22H,3,7-11H2,1H3,(H,28,31)(H,29,33)	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Displacement of 125I-MCH from MCH-R1 expressed in IMR-32 cells				Bioorg Med Chem Lett 17: 884-9 (2007) Article DOI: 10.1016/j.bmcl.2006.11.061 BindingDB Entry DOI: 10.7270/Q2J38S6V
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK3 (Homo sapiens (Human))	BDBM50537444 (CHEMBL4546009) Show SMILES CN1CCN(CC1)c1ccc(Nc2cc(NCc3cccc(NC(=O)CC#N)c3)ncn2)cc1 Show InChI InChI=1S/C25H28N8O/c1-32-11-13-33(14-12-32)22-7-5-20(6-8-22)30-24-16-23(28-18-29-24)27-17-19-3-2-4-21(15-19)31-25(34)9-10-26/h2-8,15-16,18H,9,11-14,17H2,1H3,(H,31,34)(H2,27,28,29,30)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	3.5	n/a	n/a	n/a	n/a	n/a	n/a
China Pharmaceutical University Curated by ChEMBL					Assay Description Inhibition of human JAK3 using TK-substrate-biotin preincubated for 5 mins followed by substrate addition and further incubated for 30 mins and subse...				Bioorg Med Chem 27: 1646-1657 (2019) Article DOI: 10.1016/j.bmc.2019.03.009 BindingDB Entry DOI: 10.7270/Q2PC35WG
					More data for this Ligand-Target Pair
Melanin-concentrating hormone receptor 1 (Homo sapiens (Human))	BDBM50197113 (CHEMBL214731 | N-(1-(benzo[d][1,3]dioxol-5-ylmethy...) Show SMILES Fc1ccc2oc(cc(=O)c2c1)C(=O)NC1CCN(Cc2ccc3OCOc3c2)CC1 Show InChI InChI=1S/C23H21FN2O5/c24-15-2-4-19-17(10-15)18(27)11-22(31-19)23(28)25-16-5-7-26(8-6-16)12-14-1-3-20-21(9-14)30-13-29-20/h1-4,9-11,16H,5-8,12-13H2,(H,25,28)	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Displacement of 125I-MCH from MCH-R1 expressed in IMR-32 cells				Bioorg Med Chem Lett 17: 884-9 (2007) Article DOI: 10.1016/j.bmcl.2006.11.061 BindingDB Entry DOI: 10.7270/Q2J38S6V
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM50193995 (3-((3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyr...) Show SMILES C[C@@H]1CCN(C[C@@H]1N(C)c1ncnc2[nH]ccc12)C(=O)CC#N |r| Show InChI InChI=1S/C16H20N6O/c1-11-5-8-22(14(23)3-6-17)9-13(11)21(2)16-12-4-7-18-15(12)19-10-20-16/h4,7,10-11,13H,3,5,8-9H2,1-2H3,(H,18,19,20)/t11-,13+/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	4.30	n/a	n/a	n/a	n/a	n/a	n/a
China Pharmaceutical University Curated by ChEMBL					Assay Description Inhibition of recombinant human GST-tagged JAK2 catalytic domain (809 to 1153+9 residues) expressed in baculovirus expression system using TK-biotin ...				Bioorg Med Chem 27: 1562-1576 (2019) Article DOI: 10.1016/j.bmc.2019.02.054 BindingDB Entry DOI: 10.7270/Q2VM4GQ9
					More data for this Ligand-Target Pair				3D Structure (crystal)
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM50193995 (3-((3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyr...) Show SMILES C[C@@H]1CCN(C[C@@H]1N(C)c1ncnc2[nH]ccc12)C(=O)CC#N |r| Show InChI InChI=1S/C16H20N6O/c1-11-5-8-22(14(23)3-6-17)9-13(11)21(2)16-12-4-7-18-15(12)19-10-20-16/h4,7,10-11,13H,3,5,8-9H2,1-2H3,(H,18,19,20)/t11-,13+/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	4.30	n/a	n/a	n/a	n/a	n/a	n/a
China Pharmaceutical University Curated by ChEMBL					Assay Description Inhibition of recombinant human GST-tagged JAK2 catalytic domain expressed in baculovirus expression system using TK-substrate-biotin preincubated fo...				Bioorg Med Chem 26: 4774-4786 (2018) Article DOI: 10.1016/j.bmc.2018.04.005 BindingDB Entry DOI: 10.7270/Q26Q20XK
					More data for this Ligand-Target Pair				3D Structure (crystal)
Tyrosine-protein kinase JAK3 (Homo sapiens (Human))	BDBM50537417 (CHEMBL4518786) Show SMILES O=C(CC#N)Nc1ccc(CNc2cc(Nc3ccc(cc3)N3CCOCC3)ncn2)cc1 Show InChI InChI=1S/C24H25N7O2/c25-10-9-24(32)30-20-3-1-18(2-4-20)16-26-22-15-23(28-17-27-22)29-19-5-7-21(8-6-19)31-11-13-33-14-12-31/h1-8,15,17H,9,11-14,16H2,(H,30,32)(H2,26,27,28,29)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	4.80	n/a	n/a	n/a	n/a	n/a	n/a
China Pharmaceutical University Curated by ChEMBL					Assay Description Inhibition of human JAK3 using TK-substrate-biotin preincubated for 5 mins followed by substrate addition and further incubated for 30 mins and subse...				Bioorg Med Chem 27: 1646-1657 (2019) Article DOI: 10.1016/j.bmc.2019.03.009 BindingDB Entry DOI: 10.7270/Q2PC35WG
					More data for this Ligand-Target Pair
Melanin-concentrating hormone receptor 1 (Homo sapiens (Human))	BDBM50201273 (CHEMBL214585 | N-(1-(6,7-dihydro-5H-indeno[5,6-d][...) Show SMILES Fc1ccc2oc(cc(=O)c2c1)C(=O)NC1CCN(CC1)C1CCc2cc3OCOc3cc12 Show InChI InChI=1S/C25H23FN2O5/c26-15-2-4-21-18(10-15)20(29)12-24(33-21)25(30)27-16-5-7-28(8-6-16)19-3-1-14-9-22-23(11-17(14)19)32-13-31-22/h2,4,9-12,16,19H,1,3,5-8,13H2,(H,27,30)	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Displacement of 125I-MCH from MCH-R1 expressed in IMR-32 cells				Bioorg Med Chem Lett 17: 884-9 (2007) Article DOI: 10.1016/j.bmcl.2006.11.061 BindingDB Entry DOI: 10.7270/Q2J38S6V
					More data for this Ligand-Target Pair
Melanin-concentrating hormone receptor 1 (Homo sapiens (Human))	BDBM50201273 (CHEMBL214585 | N-(1-(6,7-dihydro-5H-indeno[5,6-d][...) Show SMILES Fc1ccc2oc(cc(=O)c2c1)C(=O)NC1CCN(CC1)C1CCc2cc3OCOc3cc12 Show InChI InChI=1S/C25H23FN2O5/c26-15-2-4-21-18(10-15)20(29)12-24(33-21)25(30)27-16-5-7-28(8-6-16)19-3-1-14-9-22-23(11-17(14)19)32-13-31-22/h2,4,9-12,16,19H,1,3,5-8,13H2,(H,27,30)	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Displacement of 125I-MCH from MCH-R1 expressed in IMR-32 cells				Bioorg Med Chem Lett 17: 884-9 (2007) Article DOI: 10.1016/j.bmcl.2006.11.061 BindingDB Entry DOI: 10.7270/Q2J38S6V
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK3 (Homo sapiens (Human))	BDBM50463796 (CHEMBL4244148) Show SMILES Cn1cc(cn1)-c1nn(C2CCCN(C2)C(=O)C=C)c2ncnc(N)c12 Show InChI InChI=1S/C17H20N8O/c1-3-13(26)24-6-4-5-12(9-24)25-17-14(16(18)19-10-20-17)15(22-25)11-7-21-23(2)8-11/h3,7-8,10,12H,1,4-6,9H2,2H3,(H2,18,19,20)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	6.20	n/a	n/a	n/a	n/a	n/a	n/a
China Pharmaceutical University Curated by ChEMBL					Assay Description Inhibition of recombinant human GST-tagged JAK3 catalytic domain expressed in baculovirus expression system using TK-substrate-biotin preincubated fo...				Bioorg Med Chem 26: 4774-4786 (2018) Article DOI: 10.1016/j.bmc.2018.04.005 BindingDB Entry DOI: 10.7270/Q26Q20XK
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM50526450 (CHEMBL4454392) Show SMILES Cn1nc(cc1C(C)(C)O)-c1nn(C2CCCN(C2)C(=O)C=C)c2ncnc(N)c12 Show InChI InChI=1S/C20H26N8O2/c1-5-15(29)27-8-6-7-12(10-27)28-19-16(18(21)22-11-23-19)17(25-28)13-9-14(20(2,3)30)26(4)24-13/h5,9,11-12,30H,1,6-8,10H2,2-4H3,(H2,21,22,23)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	6.5	n/a	n/a	n/a	n/a	n/a	n/a
China Pharmaceutical University Curated by ChEMBL					Assay Description Inhibition of recombinant human GST-tagged JAK2 catalytic domain (809 to 1153+9 residues) expressed in baculovirus expression system using TK-biotin ...				Bioorg Med Chem 27: 1562-1576 (2019) Article DOI: 10.1016/j.bmc.2019.02.054 BindingDB Entry DOI: 10.7270/Q2VM4GQ9
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK3 (Homo sapiens (Human))	BDBM50537441 (CHEMBL4574614) Show SMILES COCCn1cc(Nc2cc(NCc3cccc(NC(=O)C=C)c3)ncn2)cn1 Show InChI InChI=1S/C20H23N7O2/c1-3-20(28)26-16-6-4-5-15(9-16)11-21-18-10-19(23-14-22-18)25-17-12-24-27(13-17)7-8-29-2/h3-6,9-10,12-14H,1,7-8,11H2,2H3,(H,26,28)(H2,21,22,23,25)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	7	n/a	n/a	n/a	n/a	n/a	n/a
China Pharmaceutical University Curated by ChEMBL					Assay Description Inhibition of human JAK3 using TK-substrate-biotin preincubated for 5 mins followed by substrate addition and further incubated for 30 mins and subse...				Bioorg Med Chem 27: 1646-1657 (2019) Article DOI: 10.1016/j.bmc.2019.03.009 BindingDB Entry DOI: 10.7270/Q2PC35WG
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK3 (Homo sapiens (Human))	BDBM50537415 (CHEMBL4572373) Show SMILES OCCn1cc(Nc2cc(NCc3cccc(NC(=O)C=C)c3)ncn2)cn1 Show InChI InChI=1S/C19H21N7O2/c1-2-19(28)25-15-5-3-4-14(8-15)10-20-17-9-18(22-13-21-17)24-16-11-23-26(12-16)6-7-27/h2-5,8-9,11-13,27H,1,6-7,10H2,(H,25,28)(H2,20,21,22,24)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	7.20	n/a	n/a	n/a	n/a	n/a	n/a
China Pharmaceutical University Curated by ChEMBL					Assay Description Inhibition of human JAK3 using TK-substrate-biotin preincubated for 5 mins followed by substrate addition and further incubated for 30 mins and subse...				Bioorg Med Chem 27: 1646-1657 (2019) Article DOI: 10.1016/j.bmc.2019.03.009 BindingDB Entry DOI: 10.7270/Q2PC35WG
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM50526452 (CHEMBL4557416) Show SMILES Cn1nc(cc1C(C)(C)O)-c1nn(C2CCN(C2)C(=O)C=C)c2ncnc(N)c12 Show InChI InChI=1S/C19H24N8O2/c1-5-14(28)26-7-6-11(9-26)27-18-15(17(20)21-10-22-18)16(24-27)12-8-13(19(2,3)29)25(4)23-12/h5,8,10-11,29H,1,6-7,9H2,2-4H3,(H2,20,21,22)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	7.20	n/a	n/a	n/a	n/a	n/a	n/a
China Pharmaceutical University Curated by ChEMBL					Assay Description Inhibition of recombinant human GST-tagged JAK2 catalytic domain (809 to 1153+9 residues) expressed in baculovirus expression system using TK-biotin ...				Bioorg Med Chem 27: 1562-1576 (2019) Article DOI: 10.1016/j.bmc.2019.02.054 BindingDB Entry DOI: 10.7270/Q2VM4GQ9
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK3 (Homo sapiens (Human))	BDBM50537433 (CHEMBL4563864) Show SMILES COCCn1cc(Nc2cc(NCc3cccc(NC(=O)CC#N)c3)ncn2)cn1 Show InChI InChI=1S/C20H22N8O2/c1-30-8-7-28-13-17(12-25-28)26-19-10-18(23-14-24-19)22-11-15-3-2-4-16(9-15)27-20(29)5-6-21/h2-4,9-10,12-14H,5,7-8,11H2,1H3,(H,27,29)(H2,22,23,24,26)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	7.30	n/a	n/a	n/a	n/a	n/a	n/a
China Pharmaceutical University Curated by ChEMBL					Assay Description Inhibition of human JAK3 using TK-substrate-biotin preincubated for 5 mins followed by substrate addition and further incubated for 30 mins and subse...				Bioorg Med Chem 27: 1646-1657 (2019) Article DOI: 10.1016/j.bmc.2019.03.009 BindingDB Entry DOI: 10.7270/Q2PC35WG
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK3 (Homo sapiens (Human))	BDBM50537442 (CHEMBL4577029) Show SMILES CN1CCN(CC1)c1ccc(Nc2cc(NCc3ccc(NC(=O)C=C)cc3)ncn2)cc1 Show InChI InChI=1S/C25H29N7O/c1-3-25(33)30-21-6-4-19(5-7-21)17-26-23-16-24(28-18-27-23)29-20-8-10-22(11-9-20)32-14-12-31(2)13-15-32/h3-11,16,18H,1,12-15,17H2,2H3,(H,30,33)(H2,26,27,28,29)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	7.90	n/a	n/a	n/a	n/a	n/a	n/a
China Pharmaceutical University Curated by ChEMBL					Assay Description Inhibition of human JAK3 using TK-substrate-biotin preincubated for 5 mins followed by substrate addition and further incubated for 30 mins and subse...				Bioorg Med Chem 27: 1646-1657 (2019) Article DOI: 10.1016/j.bmc.2019.03.009 BindingDB Entry DOI: 10.7270/Q2PC35WG
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM50526471 (CHEMBL4590390) Show SMILES Cn1nc(cc1C(C)(C)O)-c1nn(C2CCCN(C2)C(=O)CC#N)c2ncnc(N)c12 Show InChI InChI=1S/C20H25N9O2/c1-20(2,31)14-9-13(25-27(14)3)17-16-18(22)23-11-24-19(16)29(26-17)12-5-4-8-28(10-12)15(30)6-7-21/h9,11-12,31H,4-6,8,10H2,1-3H3,(H2,22,23,24)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	8	n/a	n/a	n/a	n/a	n/a	n/a
China Pharmaceutical University Curated by ChEMBL					Assay Description Inhibition of recombinant human GST-tagged JAK2 catalytic domain (809 to 1153+9 residues) expressed in baculovirus expression system using TK-biotin ...				Bioorg Med Chem 27: 1562-1576 (2019) Article DOI: 10.1016/j.bmc.2019.02.054 BindingDB Entry DOI: 10.7270/Q2VM4GQ9
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK3 (Homo sapiens (Human))	BDBM50537421 (CHEMBL4566849) Show SMILES C=CC(=O)Nc1ccc(CNc2cc(Nc3ccc(cc3)N3CCOCC3)ncn2)cc1 Show InChI InChI=1S/C24H26N6O2/c1-2-24(31)29-20-5-3-18(4-6-20)16-25-22-15-23(27-17-26-22)28-19-7-9-21(10-8-19)30-11-13-32-14-12-30/h2-10,15,17H,1,11-14,16H2,(H,29,31)(H2,25,26,27,28)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	8.40	n/a	n/a	n/a	n/a	n/a	n/a
China Pharmaceutical University Curated by ChEMBL					Assay Description Inhibition of human JAK3 using TK-substrate-biotin preincubated for 5 mins followed by substrate addition and further incubated for 30 mins and subse...				Bioorg Med Chem 27: 1646-1657 (2019) Article DOI: 10.1016/j.bmc.2019.03.009 BindingDB Entry DOI: 10.7270/Q2PC35WG
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK3 (Homo sapiens (Human))	BDBM50537426 (CHEMBL4593058) Show SMILES COCCn1cc(Nc2cc(NCc3ccc(NC(=O)C=C)cc3)ncn2)cn1 Show InChI InChI=1S/C20H23N7O2/c1-3-20(28)26-16-6-4-15(5-7-16)11-21-18-10-19(23-14-22-18)25-17-12-24-27(13-17)8-9-29-2/h3-7,10,12-14H,1,8-9,11H2,2H3,(H,26,28)(H2,21,22,23,25)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	9.30	n/a	n/a	n/a	n/a	n/a	n/a
China Pharmaceutical University Curated by ChEMBL					Assay Description Inhibition of human JAK3 using TK-substrate-biotin preincubated for 5 mins followed by substrate addition and further incubated for 30 mins and subse...				Bioorg Med Chem 27: 1646-1657 (2019) Article DOI: 10.1016/j.bmc.2019.03.009 BindingDB Entry DOI: 10.7270/Q2PC35WG
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK3 (Homo sapiens (Human))	BDBM50537436 (CHEMBL4541547) Show SMILES OCCn1cc(Nc2cc(NCc3ccc(NC(=O)C=C)cc3)ncn2)cn1 Show InChI InChI=1S/C19H21N7O2/c1-2-19(28)25-15-5-3-14(4-6-15)10-20-17-9-18(22-13-21-17)24-16-11-23-26(12-16)7-8-27/h2-6,9,11-13,27H,1,7-8,10H2,(H,25,28)(H2,20,21,22,24)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	9.40	n/a	n/a	n/a	n/a	n/a	n/a
China Pharmaceutical University Curated by ChEMBL					Assay Description Inhibition of human JAK3 using TK-substrate-biotin preincubated for 5 mins followed by substrate addition and further incubated for 30 mins and subse...				Bioorg Med Chem 27: 1646-1657 (2019) Article DOI: 10.1016/j.bmc.2019.03.009 BindingDB Entry DOI: 10.7270/Q2PC35WG
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM50526461 (CHEMBL4561431) Show SMILES Cn1nc(cc1C=O)-c1nn(C2CCN(C2)C(=O)C=C)c2ncnc(N)c12 Show InChI InChI=1S/C17H18N8O2/c1-3-13(27)24-5-4-10(7-24)25-17-14(16(18)19-9-20-17)15(22-25)12-6-11(8-26)23(2)21-12/h3,6,8-10H,1,4-5,7H2,2H3,(H2,18,19,20)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	9.70	n/a	n/a	n/a	n/a	n/a	n/a
China Pharmaceutical University Curated by ChEMBL					Assay Description Inhibition of recombinant human GST-tagged JAK2 catalytic domain (809 to 1153+9 residues) expressed in baculovirus expression system using TK-biotin ...				Bioorg Med Chem 27: 1562-1576 (2019) Article DOI: 10.1016/j.bmc.2019.02.054 BindingDB Entry DOI: 10.7270/Q2VM4GQ9
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK3 (Homo sapiens (Human))	BDBM50463800 (CHEMBL4249310) Show SMILES Cn1cc(cn1)-c1nn(C2CCN(C2)C(=O)C=C)c2ncnc(N)c12 Show InChI InChI=1S/C16H18N8O/c1-3-12(25)23-5-4-11(8-23)24-16-13(15(17)18-9-19-16)14(21-24)10-6-20-22(2)7-10/h3,6-7,9,11H,1,4-5,8H2,2H3,(H2,17,18,19)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	9.90	n/a	n/a	n/a	n/a	n/a	n/a
China Pharmaceutical University Curated by ChEMBL					Assay Description Inhibition of recombinant human GST-tagged JAK3 catalytic domain expressed in baculovirus expression system using TK-substrate-biotin preincubated fo...				Bioorg Med Chem 26: 4774-4786 (2018) Article DOI: 10.1016/j.bmc.2018.04.005 BindingDB Entry DOI: 10.7270/Q26Q20XK
					More data for this Ligand-Target Pair
Melanin-concentrating hormone receptor 1 (Homo sapiens (Human))	BDBM50201271 (7-fluoro-4-oxo-N-(1-(2-oxo-3,5,6,7-tetrahydro-2H-i...) Show SMILES Fc1ccc2c(c1)oc(cc2=O)C(=O)NC1CCN(CC1)C1CCc2cc3oc(=O)[nH]c3cc12 Show InChI InChI=1S/C25H22FN3O5/c26-14-2-3-16-20(30)12-23(33-21(16)10-14)24(31)27-15-5-7-29(8-6-15)19-4-1-13-9-22-18(11-17(13)19)28-25(32)34-22/h2-3,9-12,15,19H,1,4-8H2,(H,27,31)(H,28,32)	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	11	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Displacement of 125I-MCH from MCH-R1 expressed in IMR-32 cells				Bioorg Med Chem Lett 17: 884-9 (2007) Article DOI: 10.1016/j.bmcl.2006.11.061 BindingDB Entry DOI: 10.7270/Q2J38S6V
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM50526468 (CHEMBL4442778) Show SMILES Cn1nc(cc1C=O)-c1nn(C2CCCN(C2)C(=O)C=C)c2ncnc(N)c12 Show InChI InChI=1S/C18H20N8O2/c1-3-14(28)25-6-4-5-11(8-25)26-18-15(17(19)20-10-21-18)16(23-26)13-7-12(9-27)24(2)22-13/h3,7,9-11H,1,4-6,8H2,2H3,(H2,19,20,21)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	12	n/a	n/a	n/a	n/a	n/a	n/a
China Pharmaceutical University Curated by ChEMBL					Assay Description Inhibition of recombinant human GST-tagged JAK2 catalytic domain (809 to 1153+9 residues) expressed in baculovirus expression system using TK-biotin ...				Bioorg Med Chem 27: 1562-1576 (2019) Article DOI: 10.1016/j.bmc.2019.02.054 BindingDB Entry DOI: 10.7270/Q2VM4GQ9
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK3 (Homo sapiens (Human))	BDBM50537425 (CHEMBL4539137) Show SMILES Cn1cc(Nc2cc(NCc3cccc(NC(=O)C=C)c3)ncn2)cn1 Show InChI InChI=1S/C18H19N7O/c1-3-18(26)24-14-6-4-5-13(7-14)9-19-16-8-17(21-12-20-16)23-15-10-22-25(2)11-15/h3-8,10-12H,1,9H2,2H3,(H,24,26)(H2,19,20,21,23)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	12	n/a	n/a	n/a	n/a	n/a	n/a
China Pharmaceutical University Curated by ChEMBL					Assay Description Inhibition of human JAK3 using TK-substrate-biotin preincubated for 5 mins followed by substrate addition and further incubated for 30 mins and subse...				Bioorg Med Chem 27: 1646-1657 (2019) Article DOI: 10.1016/j.bmc.2019.03.009 BindingDB Entry DOI: 10.7270/Q2PC35WG
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM50526451 (CHEMBL4460560) Show SMILES Cn1nc(cc1N1CCOCC1)-c1nn(C2CCCN(C2)C(=O)C=C)c2ncnc(N)c12 Show InChI InChI=1S/C21H27N9O2/c1-3-17(31)29-6-4-5-14(12-29)30-21-18(20(22)23-13-24-21)19(26-30)15-11-16(27(2)25-15)28-7-9-32-10-8-28/h3,11,13-14H,1,4-10,12H2,2H3,(H2,22,23,24)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	13	n/a	n/a	n/a	n/a	n/a	n/a
China Pharmaceutical University Curated by ChEMBL					Assay Description Inhibition of recombinant human GST-tagged JAK2 catalytic domain (809 to 1153+9 residues) expressed in baculovirus expression system using TK-biotin ...				Bioorg Med Chem 27: 1562-1576 (2019) Article DOI: 10.1016/j.bmc.2019.02.054 BindingDB Entry DOI: 10.7270/Q2VM4GQ9
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM50526470 (CHEMBL4457338) Show SMILES Cn1nc(cc1C(C)(C)O)-c1nn(CC2CCN(CC2)C(=O)C=C)c2ncnc(N)c12 Show InChI InChI=1S/C21H28N8O2/c1-5-16(30)28-8-6-13(7-9-28)11-29-20-17(19(22)23-12-24-20)18(26-29)14-10-15(21(2,3)31)27(4)25-14/h5,10,12-13,31H,1,6-9,11H2,2-4H3,(H2,22,23,24)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	15	n/a	n/a	n/a	n/a	n/a	n/a
China Pharmaceutical University Curated by ChEMBL					Assay Description Inhibition of recombinant human GST-tagged JAK2 catalytic domain (809 to 1153+9 residues) expressed in baculovirus expression system using TK-biotin ...				Bioorg Med Chem 27: 1562-1576 (2019) Article DOI: 10.1016/j.bmc.2019.02.054 BindingDB Entry DOI: 10.7270/Q2VM4GQ9
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK3 (Homo sapiens (Human))	BDBM50463792 (CHEMBL4245422) Show SMILES COCCn1cc(cn1)-c1nn(C2CCN(C2)C(=O)C=C)c2ncnc(N)c12 Show InChI InChI=1S/C18H22N8O2/c1-3-14(27)24-5-4-13(10-24)26-18-15(17(19)20-11-21-18)16(23-26)12-8-22-25(9-12)6-7-28-2/h3,8-9,11,13H,1,4-7,10H2,2H3,(H2,19,20,21)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	16	n/a	n/a	n/a	n/a	n/a	n/a
China Pharmaceutical University Curated by ChEMBL					Assay Description Inhibition of recombinant human GST-tagged JAK3 catalytic domain expressed in baculovirus expression system using TK-substrate-biotin preincubated fo...				Bioorg Med Chem 26: 4774-4786 (2018) Article DOI: 10.1016/j.bmc.2018.04.005 BindingDB Entry DOI: 10.7270/Q26Q20XK
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK3 (Homo sapiens (Human))	BDBM50463799 (CHEMBL4241272) Show SMILES Cn1cc(cn1)-c1nn(CC2CCCN(C2)C(=O)C=C)c2ncnc(N)c12 Show InChI InChI=1S/C18H22N8O/c1-3-14(27)25-6-4-5-12(8-25)9-26-18-15(17(19)20-11-21-18)16(23-26)13-7-22-24(2)10-13/h3,7,10-12H,1,4-6,8-9H2,2H3,(H2,19,20,21)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	19	n/a	n/a	n/a	n/a	n/a	n/a
China Pharmaceutical University Curated by ChEMBL					Assay Description Inhibition of recombinant human GST-tagged JAK3 catalytic domain expressed in baculovirus expression system using TK-substrate-biotin preincubated fo...				Bioorg Med Chem 26: 4774-4786 (2018) Article DOI: 10.1016/j.bmc.2018.04.005 BindingDB Entry DOI: 10.7270/Q26Q20XK
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK3 (Homo sapiens (Human))	BDBM50526446 (CHEMBL4517080) Show SMILES Nc1ncnc2n(CC3CCCN(C3)C(=O)C=C)nc(Br)c12 Show InChI InChI=1S/C14H17BrN6O/c1-2-10(22)20-5-3-4-9(6-20)7-21-14-11(12(15)19-21)13(16)17-8-18-14/h2,8-9H,1,3-7H2,(H2,16,17,18)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	21	n/a	n/a	n/a	n/a	n/a	n/a
China Pharmaceutical University Curated by ChEMBL					Assay Description Inhibition of recombinant human GST-tagged JAK3 catalytic domain (781 to 1124 residues) expressed in baculovirus expression system using TK-biotin as...				Bioorg Med Chem 27: 1562-1576 (2019) Article DOI: 10.1016/j.bmc.2019.02.054 BindingDB Entry DOI: 10.7270/Q2VM4GQ9
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK3 (Homo sapiens (Human))	BDBM50463801 (CHEMBL4249492) Show SMILES COCCn1cc(cn1)-c1nn(C2CCCN(C2)C(=O)C=C)c2ncnc(N)c12 Show InChI InChI=1S/C19H24N8O2/c1-3-15(28)25-6-4-5-14(11-25)27-19-16(18(20)21-12-22-19)17(24-27)13-9-23-26(10-13)7-8-29-2/h3,9-10,12,14H,1,4-8,11H2,2H3,(H2,20,21,22)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	21	n/a	n/a	n/a	n/a	n/a	n/a
China Pharmaceutical University Curated by ChEMBL					Assay Description Inhibition of recombinant human GST-tagged JAK3 catalytic domain expressed in baculovirus expression system using TK-substrate-biotin preincubated fo...				Bioorg Med Chem 26: 4774-4786 (2018) Article DOI: 10.1016/j.bmc.2018.04.005 BindingDB Entry DOI: 10.7270/Q26Q20XK
					More data for this Ligand-Target Pair
Melanin-concentrating hormone receptor 1 (Homo sapiens (Human))	BDBM50201275 (7-fluoro-4-oxo-N-(1-(3-oxo-2,3,4,6,7,8-hexahydroin...) Show SMILES Fc1ccc2c(c1)oc(cc2=O)C(=O)NC1CCN(CC1)C1CCc2cc3OCC(=O)Nc3cc12 Show InChI InChI=1S/C26H24FN3O5/c27-15-2-3-17-21(31)12-24(35-22(17)10-15)26(33)28-16-5-7-30(8-6-16)20-4-1-14-9-23-19(11-18(14)20)29-25(32)13-34-23/h2-3,9-12,16,20H,1,4-8,13H2,(H,28,33)(H,29,32)	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	21	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Displacement of 125I-MCH from MCH-R1 expressed in IMR-32 cells				Bioorg Med Chem Lett 17: 884-9 (2007) Article DOI: 10.1016/j.bmcl.2006.11.061 BindingDB Entry DOI: 10.7270/Q2J38S6V
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK3 (Homo sapiens (Human))	BDBM50526475 (CHEMBL4554776) Show SMILES Nc1ncnc2n(nc(I)c12)C1CCCN(C1)C(=O)C=C Show InChI InChI=1S/C13H15IN6O/c1-2-9(21)19-5-3-4-8(6-19)20-13-10(11(14)18-20)12(15)16-7-17-13/h2,7-8H,1,3-6H2,(H2,15,16,17)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	22	n/a	n/a	n/a	n/a	n/a	n/a
China Pharmaceutical University Curated by ChEMBL					Assay Description Inhibition of recombinant human GST-tagged JAK3 catalytic domain (781 to 1124 residues) expressed in baculovirus expression system using TK-biotin as...				Bioorg Med Chem 27: 1562-1576 (2019) Article DOI: 10.1016/j.bmc.2019.02.054 BindingDB Entry DOI: 10.7270/Q2VM4GQ9
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK3 (Homo sapiens (Human))	BDBM50537418 (CHEMBL4526018) Show SMILES Cn1cc(Nc2cc(NCc3ccc(NC(=O)C=C)cc3)ncn2)cn1 Show InChI InChI=1S/C18H19N7O/c1-3-18(26)24-14-6-4-13(5-7-14)9-19-16-8-17(21-12-20-16)23-15-10-22-25(2)11-15/h3-8,10-12H,1,9H2,2H3,(H,24,26)(H2,19,20,21,23)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	24	n/a	n/a	n/a	n/a	n/a	n/a
China Pharmaceutical University Curated by ChEMBL					Assay Description Inhibition of human JAK3 using TK-substrate-biotin preincubated for 5 mins followed by substrate addition and further incubated for 30 mins and subse...				Bioorg Med Chem 27: 1646-1657 (2019) Article DOI: 10.1016/j.bmc.2019.03.009 BindingDB Entry DOI: 10.7270/Q2PC35WG
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (Homo sapiens (Human))	BDBM50193995 (3-((3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyr...) Show SMILES C[C@@H]1CCN(C[C@@H]1N(C)c1ncnc2[nH]ccc12)C(=O)CC#N |r| Show InChI InChI=1S/C16H20N6O/c1-11-5-8-22(14(23)3-6-17)9-13(11)21(2)16-12-4-7-18-15(12)19-10-20-16/h4,7,10-11,13H,3,5,8-9H2,1-2H3,(H,18,19,20)/t11-,13+/m1/s1	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars	DrugBank PDB Article PubMed	n/a	n/a	32	n/a	n/a	n/a	n/a	n/a	n/a
China Pharmaceutical University Curated by ChEMBL					Assay Description Inhibition of human TYK2 using TK-substrate-biotin preincubated for 5 mins followed by substrate addition and further incubated for 30 mins and subse...				Bioorg Med Chem 27: 1646-1657 (2019) Article DOI: 10.1016/j.bmc.2019.03.009 BindingDB Entry DOI: 10.7270/Q2PC35WG
					More data for this Ligand-Target Pair				3D Structure (crystal)
Tyrosine-protein kinase JAK3 (Homo sapiens (Human))	BDBM50463795 (CHEMBL4248202) Show SMILES Cn1cc(cn1)-c1nn(C2CCCN(C2)C(=O)CC#N)c2ncnc(N)c12 Show InChI InChI=1S/C17H19N9O/c1-24-8-11(7-22-24)15-14-16(19)20-10-21-17(14)26(23-15)12-3-2-6-25(9-12)13(27)4-5-18/h7-8,10,12H,2-4,6,9H2,1H3,(H2,19,20,21)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	32	n/a	n/a	n/a	n/a	n/a	n/a
China Pharmaceutical University Curated by ChEMBL					Assay Description Inhibition of recombinant human GST-tagged JAK3 catalytic domain expressed in baculovirus expression system using TK-substrate-biotin preincubated fo...				Bioorg Med Chem 26: 4774-4786 (2018) Article DOI: 10.1016/j.bmc.2018.04.005 BindingDB Entry DOI: 10.7270/Q26Q20XK
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK3 (Homo sapiens (Human))	BDBM209866 (PF-06651600 | US11111242, Example 5 | US2023034848...) Show SMILES C[C@H]1CC[C@H](CN1C(=O)C=C)Nc1ncnc2[nH]ccc12 |r| Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	Article PubMed	n/a	n/a	33	n/a	n/a	n/a	n/a	n/a	n/a
China Pharmaceutical University Curated by ChEMBL					Assay Description Inhibition of JAK3 (unknown origin)				Bioorg Med Chem 27: 1646-1657 (2019) Article DOI: 10.1016/j.bmc.2019.03.009 BindingDB Entry DOI: 10.7270/Q2PC35WG
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK3 (Homo sapiens (Human))	BDBM50526456 (CHEMBL4582632) Show SMILES Nc1ncnc2n(nc(Br)c12)C1CCCN(C1)C(=O)C=C Show InChI InChI=1S/C13H15BrN6O/c1-2-9(21)19-5-3-4-8(6-19)20-13-10(11(14)18-20)12(15)16-7-17-13/h2,7-8H,1,3-6H2,(H2,15,16,17)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	34	n/a	n/a	n/a	n/a	n/a	n/a
China Pharmaceutical University Curated by ChEMBL					Assay Description Inhibition of recombinant human GST-tagged JAK3 catalytic domain (781 to 1124 residues) expressed in baculovirus expression system using TK-biotin as...				Bioorg Med Chem 27: 1562-1576 (2019) Article DOI: 10.1016/j.bmc.2019.02.054 BindingDB Entry DOI: 10.7270/Q2VM4GQ9
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (Homo sapiens (Human))	BDBM50193995 (3-((3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyr...) Show SMILES C[C@@H]1CCN(C[C@@H]1N(C)c1ncnc2[nH]ccc12)C(=O)CC#N |r| Show InChI InChI=1S/C16H20N6O/c1-11-5-8-22(14(23)3-6-17)9-13(11)21(2)16-12-4-7-18-15(12)19-10-20-16/h4,7,10-11,13H,3,5,8-9H2,1-2H3,(H,18,19,20)/t11-,13+/m1/s1	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars	DrugBank PDB Article PubMed	n/a	n/a	36	n/a	n/a	n/a	n/a	n/a	n/a
China Pharmaceutical University Curated by ChEMBL					Assay Description Inhibition of recombinant human GST-tagged TYK2 catalytic domain expressed in baculovirus expression system using TK-substrate-biotin preincubated fo...				Bioorg Med Chem 26: 4774-4786 (2018) Article DOI: 10.1016/j.bmc.2018.04.005 BindingDB Entry DOI: 10.7270/Q26Q20XK
					More data for this Ligand-Target Pair				3D Structure (crystal)
Tyrosine-protein kinase JAK3 (Homo sapiens (Human))	BDBM50463794 (CHEMBL4249872) Show SMILES COCCn1cc(cn1)-c1nn(CC2CCCN(C2)C(=O)C=C)c2ncnc(N)c12 Show InChI InChI=1S/C20H26N8O2/c1-3-16(29)26-6-4-5-14(10-26)11-28-20-17(19(21)22-13-23-20)18(25-28)15-9-24-27(12-15)7-8-30-2/h3,9,12-14H,1,4-8,10-11H2,2H3,(H2,21,22,23)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	36	n/a	n/a	n/a	n/a	n/a	n/a
China Pharmaceutical University Curated by ChEMBL					Assay Description Inhibition of recombinant human GST-tagged JAK3 catalytic domain expressed in baculovirus expression system using TK-substrate-biotin preincubated fo...				Bioorg Med Chem 26: 4774-4786 (2018) Article DOI: 10.1016/j.bmc.2018.04.005 BindingDB Entry DOI: 10.7270/Q26Q20XK
					More data for this Ligand-Target Pair

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