Compile Data Set for Download or QSAR

Found 55 hits with Last Name = 'ciecko' and Initial = 'pa'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM5330 (3-{5-[2-(4-acetylpiperazin-1-yl)ethoxy]-1H-indol-2...) Show SMILES CC(=O)N1CCN(CCOc2ccc3[nH]c(cc3c2)-c2cc3ccccc3[nH]c2=O)CC1 Show InChI InChI=1S/C25H26N4O3/c1-17(30)29-10-8-28(9-11-29)12-13-32-20-6-7-23-19(14-20)16-24(26-23)21-15-18-4-2-3-5-22(18)27-25(21)31/h2-7,14-16,26H,8-13H2,1H3,(H,27,31)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4	n/a	n/a	n/a	n/a	7.4	22
Merck Research Laboratories					Assay Description Activated KDR was incubated with 25 uM/10 uCi of [gamma-33P] ATP, poly-Glu/Tyr, and inhibitors in kinase buffer for 15 min at 22 °C. The reactio...				Bioorg Med Chem Lett 14: 351-5 (2004) Article DOI: 10.1016/j.bmcl.2003.11.007 BindingDB Entry DOI: 10.7270/Q298856Z
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM5332 (3-{5-[2-(piperidin-1-yl)ethoxy]-1H-indol-2-yl}-1,2...) Show SMILES O=c1[nH]c2ccccc2cc1-c1cc2cc(OCCN3CCCCC3)ccc2[nH]1 Show InChI InChI=1S/C24H25N3O2/c28-24-20(15-17-6-2-3-7-21(17)26-24)23-16-18-14-19(8-9-22(18)25-23)29-13-12-27-10-4-1-5-11-27/h2-3,6-9,14-16,25H,1,4-5,10-13H2,(H,26,28)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	4	n/a	n/a	n/a	n/a	7.4	22
Merck Research Laboratories					Assay Description Activated KDR was incubated with 25 uM/10 uCi of [gamma-33P] ATP, poly-Glu/Tyr, and inhibitors in kinase buffer for 15 min at 22 °C. The reactio...				Bioorg Med Chem Lett 14: 351-5 (2004) Article DOI: 10.1016/j.bmcl.2003.11.007 BindingDB Entry DOI: 10.7270/Q298856Z
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM5335 (3-{5-[(3-aminopyrrolidin-1-yl)carbonyl]-1H-indol-2...) Show SMILES NC1CCN(C1)C(=O)c1ccc2[nH]c(cc2c1)-c1cc2ccccc2[nH]c1=O Show InChI InChI=1S/C22H20N4O2/c23-16-7-8-26(12-16)22(28)14-5-6-19-15(9-14)11-20(24-19)17-10-13-3-1-2-4-18(13)25-21(17)27/h1-6,9-11,16,24H,7-8,12,23H2,(H,25,27)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	5	n/a	n/a	n/a	n/a	7.4	22
Merck Research Laboratories					Assay Description Activated KDR was incubated with 25 uM/10 uCi of [gamma-33P] ATP, poly-Glu/Tyr, and inhibitors in kinase buffer for 15 min at 22 °C. The reactio...				Bioorg Med Chem Lett 14: 351-5 (2004) Article DOI: 10.1016/j.bmcl.2003.11.007 BindingDB Entry DOI: 10.7270/Q298856Z
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM5334 (3-[5-(piperazin-1-ylcarbonyl)-1H-indol-2-yl]-1,2-d...) Show SMILES O=C(N1CCNCC1)c1ccc2[nH]c(cc2c1)-c1cc2ccccc2[nH]c1=O Show InChI InChI=1S/C22H20N4O2/c27-21-17(12-14-3-1-2-4-18(14)25-21)20-13-16-11-15(5-6-19(16)24-20)22(28)26-9-7-23-8-10-26/h1-6,11-13,23-24H,7-10H2,(H,25,27)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	5	n/a	n/a	n/a	n/a	7.4	22
Merck Research Laboratories					Assay Description Activated KDR was incubated with 25 uM/10 uCi of [gamma-33P] ATP, poly-Glu/Tyr, and inhibitors in kinase buffer for 15 min at 22 °C. The reactio...				Bioorg Med Chem Lett 14: 351-5 (2004) Article DOI: 10.1016/j.bmcl.2003.11.007 BindingDB Entry DOI: 10.7270/Q298856Z
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM5333 (3-{5-[(4-methylpiperazin-1-yl)carbonyl]-1H-indol-2...) Show SMILES CN1CCN(CC1)C(=O)c1ccc2[nH]c(cc2c1)-c1cc2ccccc2[nH]c1=O Show InChI InChI=1S/C23H22N4O2/c1-26-8-10-27(11-9-26)23(29)16-6-7-20-17(12-16)14-21(24-20)18-13-15-4-2-3-5-19(15)25-22(18)28/h2-7,12-14,24H,8-11H2,1H3,(H,25,28)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	5	n/a	n/a	n/a	n/a	7.4	22
Merck Research Laboratories					Assay Description Activated KDR was incubated with 25 uM/10 uCi of [gamma-33P] ATP, poly-Glu/Tyr, and inhibitors in kinase buffer for 15 min at 22 °C. The reactio...				Bioorg Med Chem Lett 14: 351-5 (2004) Article DOI: 10.1016/j.bmcl.2003.11.007 BindingDB Entry DOI: 10.7270/Q298856Z
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM5336 (2-(2-oxo-1,2-dihydroquinolin-3-yl)-N-(pyrrolidin-3...) Show SMILES O=C(NC1CCNC1)c1ccc2[nH]c(cc2c1)-c1cc2ccccc2[nH]c1=O Show InChI InChI=1S/C22H20N4O2/c27-21(24-16-7-8-23-12-16)14-5-6-19-15(9-14)11-20(25-19)17-10-13-3-1-2-4-18(13)26-22(17)28/h1-6,9-11,16,23,25H,7-8,12H2,(H,24,27)(H,26,28)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	6	n/a	n/a	n/a	n/a	7.4	22
Merck Research Laboratories					Assay Description Activated KDR was incubated with 25 uM/10 uCi of [gamma-33P] ATP, poly-Glu/Tyr, and inhibitors in kinase buffer for 15 min at 22 °C. The reactio...				Bioorg Med Chem Lett 14: 351-5 (2004) Article DOI: 10.1016/j.bmcl.2003.11.007 BindingDB Entry DOI: 10.7270/Q298856Z
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM5280 (5-phenyl-N-(pyridin-2-yl)-1,3-thiazol-2-amine | N-...) Show SMILES N(c1ncc(s1)-c1ccccc1)c1ccccn1 Show InChI InChI=1S/C14H11N3S/c1-2-6-11(7-3-1)12-10-16-14(18-12)17-13-8-4-5-9-15-13/h1-10H,(H,15,16,17)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	7	n/a	n/a	n/a	n/a	7.4	22
Merck Research Laboratories					Assay Description Activated KDR was incubated with 25 uM/10 uCi of [gamma-33P] ATP, poly-Glu/Tyr, and inhibitors in kinase buffer for 15 min at 22 °C. The reactio...				Bioorg Med Chem Lett 14: 351-5 (2004) Article DOI: 10.1016/j.bmcl.2003.11.007 BindingDB Entry DOI: 10.7270/Q298856Z
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM5329 (3-(5-{2-[(2-methoxyethyl)(methyl)amino]ethoxy}-1H-...) Show SMILES COCCN(C)CCOc1ccc2[nH]c(cc2c1)-c1cc2ccccc2[nH]c1=O Show InChI InChI=1S/C23H25N3O3/c1-26(9-11-28-2)10-12-29-18-7-8-21-17(13-18)15-22(24-21)19-14-16-5-3-4-6-20(16)25-23(19)27/h3-8,13-15,24H,9-12H2,1-2H3,(H,25,27)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	7	n/a	n/a	n/a	n/a	7.4	22
Merck Research Laboratories					Assay Description Activated KDR was incubated with 25 uM/10 uCi of [gamma-33P] ATP, poly-Glu/Tyr, and inhibitors in kinase buffer for 15 min at 22 °C. The reactio...				Bioorg Med Chem Lett 14: 351-5 (2004) Article DOI: 10.1016/j.bmcl.2003.11.007 BindingDB Entry DOI: 10.7270/Q298856Z
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM5331 (1-(3-{[2-(2-oxo-1,2-dihydroquinolin-3-yl)-1H-indol...) Show SMILES OC(=O)C1CCN(CCCOc2ccc3[nH]c(cc3c2)-c2cc3ccccc3[nH]c2=O)CC1 Show InChI InChI=1S/C26H27N3O4/c30-25-21(15-18-4-1-2-5-22(18)28-25)24-16-19-14-20(6-7-23(19)27-24)33-13-3-10-29-11-8-17(9-12-29)26(31)32/h1-2,4-7,14-17,27H,3,8-13H2,(H,28,30)(H,31,32)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	8	n/a	n/a	n/a	n/a	7.4	22
Merck Research Laboratories					Assay Description Activated KDR was incubated with 25 uM/10 uCi of [gamma-33P] ATP, poly-Glu/Tyr, and inhibitors in kinase buffer for 15 min at 22 °C. The reactio...				Bioorg Med Chem Lett 14: 351-5 (2004) Article DOI: 10.1016/j.bmcl.2003.11.007 BindingDB Entry DOI: 10.7270/Q298856Z
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50179418 (2-(6-(4-aminoazepan-1-yl)pyrimidin-4-ylamino)thiaz...) Show SMILES NC1CCCN(CC1)c1cc(Nc2ncc(s2)C#N)ncn1 Show InChI InChI=1S/C14H17N7S/c15-7-11-8-17-14(22-11)20-12-6-13(19-9-18-12)21-4-1-2-10(16)3-5-21/h6,8-10H,1-5,16H2,(H,17,18,19,20)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	9	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of KDR				Bioorg Med Chem Lett 16: 1146-50 (2006) Article DOI: 10.1016/j.bmcl.2005.11.089 BindingDB Entry DOI: 10.7270/Q279448N
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50179415 (2-(6-(4-(2-methoxyethyl)piperazin-1-yl)pyrimidin-4...) Show SMILES COCCN1CCN(CC1)c1cc(Nc2ncc(s2)C#N)ncn1 Show InChI InChI=1S/C15H19N7OS/c1-23-7-6-21-2-4-22(5-3-21)14-8-13(18-11-19-14)20-15-17-10-12(9-16)24-15/h8,10-11H,2-7H2,1H3,(H,17,18,19,20)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	9	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of KDR				Bioorg Med Chem Lett 16: 1146-50 (2006) Article DOI: 10.1016/j.bmcl.2005.11.089 BindingDB Entry DOI: 10.7270/Q279448N
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50179427 (2-(6-(4-(2-(pyrrolidin-1-yl)ethyl)piperazin-1-yl)p...) Show SMILES N#Cc1cnc(Nc2cc(ncn2)N2CCN(CCN3CCCC3)CC2)s1 Show InChI InChI=1S/C18H24N8S/c19-12-15-13-20-18(27-15)23-16-11-17(22-14-21-16)26-9-7-25(8-10-26)6-5-24-3-1-2-4-24/h11,13-14H,1-10H2,(H,20,21,22,23)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	9	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of KDR				Bioorg Med Chem Lett 16: 1146-50 (2006) Article DOI: 10.1016/j.bmcl.2005.11.089 BindingDB Entry DOI: 10.7270/Q279448N
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM5337 (3-{5-[(4-methylpiperazine-1-)sulfonyl]-1H-indol-2-...) Show SMILES CN1CCN(CC1)S(=O)(=O)c1ccc2[nH]c(cc2c1)-c1cc2ccccc2[nH]c1=O Show InChI InChI=1S/C22H22N4O3S/c1-25-8-10-26(11-9-25)30(28,29)17-6-7-20-16(12-17)14-21(23-20)18-13-15-4-2-3-5-19(15)24-22(18)27/h2-7,12-14,23H,8-11H2,1H3,(H,24,27)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	10	n/a	n/a	n/a	n/a	7.4	22
Merck Research Laboratories					Assay Description Activated KDR was incubated with 25 uM/10 uCi of [gamma-33P] ATP, poly-Glu/Tyr, and inhibitors in kinase buffer for 15 min at 22 °C. The reactio...				Bioorg Med Chem Lett 14: 351-5 (2004) Article DOI: 10.1016/j.bmcl.2003.11.007 BindingDB Entry DOI: 10.7270/Q298856Z
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50179417 (2-(6-(4-methylpiperazin-1-yl)pyrimidin-4-ylamino)t...) Show SMILES CN1CCN(CC1)c1cc(Nc2ncc(s2)C#N)ncn1 Show InChI InChI=1S/C13H15N7S/c1-19-2-4-20(5-3-19)12-6-11(16-9-17-12)18-13-15-8-10(7-14)21-13/h6,8-9H,2-5H2,1H3,(H,15,16,17,18)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of KDR				Bioorg Med Chem Lett 16: 1146-50 (2006) Article DOI: 10.1016/j.bmcl.2005.11.089 BindingDB Entry DOI: 10.7270/Q279448N
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50179413 (2-(6-(4-aminopiperidin-1-yl)pyrimidin-4-ylamino)th...) Show SMILES NC1CCN(CC1)c1cc(Nc2ncc(s2)C#N)ncn1 Show InChI InChI=1S/C13H15N7S/c14-6-10-7-16-13(21-10)19-11-5-12(18-8-17-11)20-3-1-9(15)2-4-20/h5,7-9H,1-4,15H2,(H,16,17,18,19)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of KDR				Bioorg Med Chem Lett 16: 1146-50 (2006) Article DOI: 10.1016/j.bmcl.2005.11.089 BindingDB Entry DOI: 10.7270/Q279448N
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50179420 (2-(6-(4-(3-morpholinopropyl)piperazin-1-yl)pyrimid...) Show SMILES N#Cc1cnc(Nc2cc(ncn2)N2CCN(CCCN3CCOCC3)CC2)s1 Show InChI InChI=1S/C19H26N8OS/c20-13-16-14-21-19(29-16)24-17-12-18(23-15-22-17)27-6-4-25(5-7-27)2-1-3-26-8-10-28-11-9-26/h12,14-15H,1-11H2,(H,21,22,23,24)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of KDR				Bioorg Med Chem Lett 16: 1146-50 (2006) Article DOI: 10.1016/j.bmcl.2005.11.089 BindingDB Entry DOI: 10.7270/Q279448N
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM5338 (3-[5-(piperazine-1-sulfonyl)-1H-indol-2-yl]-1,2-di...) Show SMILES O=c1[nH]c2ccccc2cc1-c1cc2cc(ccc2[nH]1)S(=O)(=O)N1CCNCC1 Show InChI InChI=1S/C21H20N4O3S/c26-21-17(12-14-3-1-2-4-18(14)24-21)20-13-15-11-16(5-6-19(15)23-20)29(27,28)25-9-7-22-8-10-25/h1-6,11-13,22-23H,7-10H2,(H,24,26)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	11	n/a	n/a	n/a	n/a	7.4	22
Merck Research Laboratories					Assay Description Activated KDR was incubated with 25 uM/10 uCi of [gamma-33P] ATP, poly-Glu/Tyr, and inhibitors in kinase buffer for 15 min at 22 °C. The reactio...				Bioorg Med Chem Lett 14: 351-5 (2004) Article DOI: 10.1016/j.bmcl.2003.11.007 BindingDB Entry DOI: 10.7270/Q298856Z
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50179427 (2-(6-(4-(2-(pyrrolidin-1-yl)ethyl)piperazin-1-yl)p...) Show SMILES N#Cc1cnc(Nc2cc(ncn2)N2CCN(CCN3CCCC3)CC2)s1 Show InChI InChI=1S/C18H24N8S/c19-12-15-13-20-18(27-15)23-16-11-17(22-14-21-16)26-9-7-25(8-10-26)6-5-24-3-1-2-4-24/h11,13-14H,1-10H2,(H,20,21,22,23)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	11	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of human KDR expressed in HEK293 cells by KDR autophosphorylation assay				Bioorg Med Chem Lett 16: 1146-50 (2006) Article DOI: 10.1016/j.bmcl.2005.11.089 BindingDB Entry DOI: 10.7270/Q279448N
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50179414 (2-(6-(4-(2-morpholinoethyl)piperazin-1-yl)pyrimidi...) Show SMILES N#Cc1cnc(Nc2cc(ncn2)N2CCN(CCN3CCOCC3)CC2)s1 Show InChI InChI=1S/C18H24N8OS/c19-12-15-13-20-18(28-15)23-16-11-17(22-14-21-16)26-5-3-24(4-6-26)1-2-25-7-9-27-10-8-25/h11,13-14H,1-10H2,(H,20,21,22,23)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	12	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of KDR				Bioorg Med Chem Lett 16: 1146-50 (2006) Article DOI: 10.1016/j.bmcl.2005.11.089 BindingDB Entry DOI: 10.7270/Q279448N
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50179416 (2-(6-(4-acetylpiperazin-1-yl)pyrimidin-4-ylamino)t...) Show SMILES CC(=O)N1CCN(CC1)c1cc(Nc2ncc(s2)C#N)ncn1 Show InChI InChI=1S/C14H15N7OS/c1-10(22)20-2-4-21(5-3-20)13-6-12(17-9-18-13)19-14-16-8-11(7-15)23-14/h6,8-9H,2-5H2,1H3,(H,16,17,18,19)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	13	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of KDR				Bioorg Med Chem Lett 16: 1146-50 (2006) Article DOI: 10.1016/j.bmcl.2005.11.089 BindingDB Entry DOI: 10.7270/Q279448N
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM5340 (2-(2-oxo-1,2-dihydroquinolin-3-yl)-N-(pyrrolidin-3...) Show SMILES O=c1[nH]c2ccccc2cc1-c1cc2cc(ccc2[nH]1)S(=O)(=O)NC1CCNC1 Show InChI InChI=1S/C21H20N4O3S/c26-21-17(10-13-3-1-2-4-18(13)24-21)20-11-14-9-16(5-6-19(14)23-20)29(27,28)25-15-7-8-22-12-15/h1-6,9-11,15,22-23,25H,7-8,12H2,(H,24,26)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	14	n/a	n/a	n/a	n/a	7.4	22
Merck Research Laboratories					Assay Description Activated KDR was incubated with 25 uM/10 uCi of [gamma-33P] ATP, poly-Glu/Tyr, and inhibitors in kinase buffer for 15 min at 22 °C. The reactio...				Bioorg Med Chem Lett 14: 351-5 (2004) Article DOI: 10.1016/j.bmcl.2003.11.007 BindingDB Entry DOI: 10.7270/Q298856Z
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM5375 (1-phenyl-5-{4-[2-(piperidin-1-yl)ethoxy]phenyl}-1H...) Show SMILES C(CN1CCCCC1)Oc1ccc(cc1)-c1ccc2n(cnc2c1)-c1ccccc1 Show InChI InChI=1S/C26H27N3O/c1-3-7-23(8-4-1)29-20-27-25-19-22(11-14-26(25)29)21-9-12-24(13-10-21)30-18-17-28-15-5-2-6-16-28/h1,3-4,7-14,19-20H,2,5-6,15-18H2	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	14	n/a	n/a	n/a	n/a	7.4	22
Merck Research Laboratories					Assay Description Activated KDR was incubated with 25 uM/10 uCi of [gamma-33P] ATP, poly-Glu/Tyr, and inhibitors in kinase buffer for 15 min at 22 °C. The reactio...				Bioorg Med Chem Lett 13: 2485-8 (2003) Article DOI: 10.1016/s0960-894x(03)00485-2 BindingDB Entry DOI: 10.7270/Q21R6NQ2
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50179418 (2-(6-(4-aminoazepan-1-yl)pyrimidin-4-ylamino)thiaz...) Show SMILES NC1CCCN(CC1)c1cc(Nc2ncc(s2)C#N)ncn1 Show InChI InChI=1S/C14H17N7S/c15-7-11-8-17-14(22-11)20-12-6-13(19-9-18-12)21-4-1-2-10(16)3-5-21/h6,8-10H,1-5,16H2,(H,17,18,19,20)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	15	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of human KDR expressed in HEK293 cells by KDR autophosphorylation assay				Bioorg Med Chem Lett 16: 1146-50 (2006) Article DOI: 10.1016/j.bmcl.2005.11.089 BindingDB Entry DOI: 10.7270/Q279448N
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM5339 (3-{5-[(3-aminopyrrolidine-1-)sulfonyl]-1H-indol-2-...) Show SMILES NC1CCN(C1)S(=O)(=O)c1ccc2[nH]c(cc2c1)-c1cc2ccccc2[nH]c1=O Show InChI InChI=1S/C21H20N4O3S/c22-15-7-8-25(12-15)29(27,28)16-5-6-19-14(9-16)11-20(23-19)17-10-13-3-1-2-4-18(13)24-21(17)26/h1-6,9-11,15,23H,7-8,12,22H2,(H,24,26)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	16	n/a	n/a	n/a	n/a	7.4	22
Merck Research Laboratories					Assay Description Activated KDR was incubated with 25 uM/10 uCi of [gamma-33P] ATP, poly-Glu/Tyr, and inhibitors in kinase buffer for 15 min at 22 °C. The reactio...				Bioorg Med Chem Lett 14: 351-5 (2004) Article DOI: 10.1016/j.bmcl.2003.11.007 BindingDB Entry DOI: 10.7270/Q298856Z
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50179422 (2-(6-(piperazin-1-yl)pyrimidin-4-ylamino)thiazole-...) Show SMILES N#Cc1cnc(Nc2cc(ncn2)N2CCNCC2)s1 Show InChI InChI=1S/C12H13N7S/c13-6-9-7-15-12(20-9)18-10-5-11(17-8-16-10)19-3-1-14-2-4-19/h5,7-8,14H,1-4H2,(H,15,16,17,18)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	16	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of KDR				Bioorg Med Chem Lett 16: 1146-50 (2006) Article DOI: 10.1016/j.bmcl.2005.11.089 BindingDB Entry DOI: 10.7270/Q279448N
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50179421 ((rac)-2-(6-(3-aminopyrrolidin-1-yl)pyrimidin-4-yla...) Show SMILES NC1CCN(C1)c1cc(Nc2ncc(s2)C#N)ncn1 Show InChI InChI=1S/C12H13N7S/c13-4-9-5-15-12(20-9)18-10-3-11(17-7-16-10)19-2-1-8(14)6-19/h3,5,7-8H,1-2,6,14H2,(H,15,16,17,18)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	16	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of KDR				Bioorg Med Chem Lett 16: 1146-50 (2006) Article DOI: 10.1016/j.bmcl.2005.11.089 BindingDB Entry DOI: 10.7270/Q279448N
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50179414 (2-(6-(4-(2-morpholinoethyl)piperazin-1-yl)pyrimidi...) Show SMILES N#Cc1cnc(Nc2cc(ncn2)N2CCN(CCN3CCOCC3)CC2)s1 Show InChI InChI=1S/C18H24N8OS/c19-12-15-13-20-18(28-15)23-16-11-17(22-14-21-16)26-5-3-24(4-6-26)1-2-25-7-9-27-10-8-25/h11,13-14H,1-10H2,(H,20,21,22,23)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	19	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of human KDR expressed in HEK293 cells by KDR autophosphorylation assay				Bioorg Med Chem Lett 16: 1146-50 (2006) Article DOI: 10.1016/j.bmcl.2005.11.089 BindingDB Entry DOI: 10.7270/Q279448N
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50179421 ((rac)-2-(6-(3-aminopyrrolidin-1-yl)pyrimidin-4-yla...) Show SMILES NC1CCN(C1)c1cc(Nc2ncc(s2)C#N)ncn1 Show InChI InChI=1S/C12H13N7S/c13-4-9-5-15-12(20-9)18-10-3-11(17-7-16-10)19-2-1-8(14)6-19/h3,5,7-8H,1-2,6,14H2,(H,15,16,17,18)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	21	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of human KDR expressed in HEK293 cells by KDR autophosphorylation assay				Bioorg Med Chem Lett 16: 1146-50 (2006) Article DOI: 10.1016/j.bmcl.2005.11.089 BindingDB Entry DOI: 10.7270/Q279448N
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50179415 (2-(6-(4-(2-methoxyethyl)piperazin-1-yl)pyrimidin-4...) Show SMILES COCCN1CCN(CC1)c1cc(Nc2ncc(s2)C#N)ncn1 Show InChI InChI=1S/C15H19N7OS/c1-23-7-6-21-2-4-22(5-3-21)14-8-13(18-11-19-14)20-15-17-10-12(9-16)24-15/h8,10-11H,2-7H2,1H3,(H,17,18,19,20)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	22	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of human KDR expressed in HEK293 cells by KDR autophosphorylation assay				Bioorg Med Chem Lett 16: 1146-50 (2006) Article DOI: 10.1016/j.bmcl.2005.11.089 BindingDB Entry DOI: 10.7270/Q279448N
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50179420 (2-(6-(4-(3-morpholinopropyl)piperazin-1-yl)pyrimid...) Show SMILES N#Cc1cnc(Nc2cc(ncn2)N2CCN(CCCN3CCOCC3)CC2)s1 Show InChI InChI=1S/C19H26N8OS/c20-13-16-14-21-19(29-16)24-17-12-18(23-15-22-17)27-6-4-25(5-7-27)2-1-3-26-8-10-28-11-9-26/h12,14-15H,1-11H2,(H,21,22,23,24)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	23	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of human KDR expressed in HEK293 cells by KDR autophosphorylation assay				Bioorg Med Chem Lett 16: 1146-50 (2006) Article DOI: 10.1016/j.bmcl.2005.11.089 BindingDB Entry DOI: 10.7270/Q279448N
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM5366 (1-phenyl-5-{6-[2-(piperidin-1-yl)ethoxy]pyridin-3-...) Show SMILES C(CN1CCCCC1)Oc1ccc(cn1)-c1ccc2n(cnc2c1)-c1ccccc1 Show InChI InChI=1S/C25H26N4O/c1-3-7-22(8-4-1)29-19-27-23-17-20(9-11-24(23)29)21-10-12-25(26-18-21)30-16-15-28-13-5-2-6-14-28/h1,3-4,7-12,17-19H,2,5-6,13-16H2	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	23	n/a	n/a	n/a	n/a	7.4	22
Merck Research Laboratories					Assay Description Activated KDR was incubated with 25 uM/10 uCi of [gamma-33P] ATP, poly-Glu/Tyr, and inhibitors in kinase buffer for 15 min at 22 °C. The reactio...				Bioorg Med Chem Lett 13: 2485-8 (2003) Article DOI: 10.1016/s0960-894x(03)00485-2 BindingDB Entry DOI: 10.7270/Q21R6NQ2
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM5344 (5-phenyl-N-(pyrazin-2-yl)-1,3-thiazol-2-amine | am...) Show SMILES N(c1ncc(s1)-c1ccccc1)c1cnccn1 Show InChI InChI=1S/C13H10N4S/c1-2-4-10(5-3-1)11-8-16-13(18-11)17-12-9-14-6-7-15-12/h1-9H,(H,15,16,17)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	23	n/a	n/a	n/a	n/a	7.4	22
Merck Research Laboratories					Assay Description Activated KDR was incubated with 25 uM/10 uCi of [gamma-33P] ATP, poly-Glu/Tyr, and inhibitors in kinase buffer for 15 min at 22 °C. The reactio...				Bioorg Med Chem Lett 14: 351-5 (2004) Article DOI: 10.1016/j.bmcl.2003.11.007 BindingDB Entry DOI: 10.7270/Q298856Z
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50179417 (2-(6-(4-methylpiperazin-1-yl)pyrimidin-4-ylamino)t...) Show SMILES CN1CCN(CC1)c1cc(Nc2ncc(s2)C#N)ncn1 Show InChI InChI=1S/C13H15N7S/c1-19-2-4-20(5-3-19)12-6-11(16-9-17-12)18-13-15-8-10(7-14)21-13/h6,8-9H,2-5H2,1H3,(H,15,16,17,18)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	23	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of human KDR expressed in HEK293 cells by KDR autophosphorylation assay				Bioorg Med Chem Lett 16: 1146-50 (2006) Article DOI: 10.1016/j.bmcl.2005.11.089 BindingDB Entry DOI: 10.7270/Q279448N
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM5368 (4-(1-phenyl-1H-1,3-benzodiazol-5-yl)-1-[3-(piperid...) Show SMILES O=c1cc(ccn1CCCN1CCCCC1)-c1ccc2n(cnc2c1)-c1ccccc1 Show InChI InChI=1S/C26H28N4O/c31-26-19-22(12-17-29(26)16-7-15-28-13-5-2-6-14-28)21-10-11-25-24(18-21)27-20-30(25)23-8-3-1-4-9-23/h1,3-4,8-12,17-20H,2,5-7,13-16H2	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	25	n/a	n/a	n/a	n/a	7.4	22
Merck Research Laboratories					Assay Description Activated KDR was incubated with 25 uM/10 uCi of [gamma-33P] ATP, poly-Glu/Tyr, and inhibitors in kinase buffer for 15 min at 22 °C. The reactio...				Bioorg Med Chem Lett 13: 2485-8 (2003) Article DOI: 10.1016/s0960-894x(03)00485-2 BindingDB Entry DOI: 10.7270/Q21R6NQ2
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50179423 (2-(6-(1,4-diazepan-1-yl)pyrimidin-4-ylamino)thiazo...) Show SMILES N#Cc1cnc(Nc2cc(ncn2)N2CCCNCC2)s1 Show InChI InChI=1S/C13H15N7S/c14-7-10-8-16-13(21-10)19-11-6-12(18-9-17-11)20-4-1-2-15-3-5-20/h6,8-9,15H,1-5H2,(H,16,17,18,19)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	27	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of KDR				Bioorg Med Chem Lett 16: 1146-50 (2006) Article DOI: 10.1016/j.bmcl.2005.11.089 BindingDB Entry DOI: 10.7270/Q279448N
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50179423 (2-(6-(1,4-diazepan-1-yl)pyrimidin-4-ylamino)thiazo...) Show SMILES N#Cc1cnc(Nc2cc(ncn2)N2CCCNCC2)s1 Show InChI InChI=1S/C13H15N7S/c14-7-10-8-16-13(21-10)19-11-6-12(18-9-17-11)20-4-1-2-15-3-5-20/h6,8-9,15H,1-5H2,(H,16,17,18,19)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	32	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of human KDR expressed in HEK293 cells by KDR autophosphorylation assay				Bioorg Med Chem Lett 16: 1146-50 (2006) Article DOI: 10.1016/j.bmcl.2005.11.089 BindingDB Entry DOI: 10.7270/Q279448N
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50179422 (2-(6-(piperazin-1-yl)pyrimidin-4-ylamino)thiazole-...) Show SMILES N#Cc1cnc(Nc2cc(ncn2)N2CCNCC2)s1 Show InChI InChI=1S/C12H13N7S/c13-6-9-7-15-12(20-9)18-10-5-11(17-8-16-10)19-3-1-14-2-4-19/h5,7-8,14H,1-4H2,(H,15,16,17,18)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	34	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of human KDR expressed in HEK293 cells by KDR autophosphorylation assay				Bioorg Med Chem Lett 16: 1146-50 (2006) Article DOI: 10.1016/j.bmcl.2005.11.089 BindingDB Entry DOI: 10.7270/Q279448N
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM5345 (5-phenyl-N-(pyrimidin-4-yl)-1,3-thiazol-2-amine | ...) Show SMILES N(c1ncc(s1)-c1ccccc1)c1ccncn1 Show InChI InChI=1S/C13H10N4S/c1-2-4-10(5-3-1)11-8-15-13(18-11)17-12-6-7-14-9-16-12/h1-9H,(H,14,15,16,17)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	36	n/a	n/a	n/a	n/a	7.4	22
Merck Research Laboratories					Assay Description Activated KDR was incubated with 25 uM/10 uCi of [gamma-33P] ATP, poly-Glu/Tyr, and inhibitors in kinase buffer for 15 min at 22 °C. The reactio...				Bioorg Med Chem Lett 14: 351-5 (2004) Article DOI: 10.1016/j.bmcl.2003.11.007 BindingDB Entry DOI: 10.7270/Q298856Z
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM5376 (1-[2-(4-{3-phenyl-3H-imidazo[4,5-b]pyridin-6-yl}ph...) Show SMILES C(CN1CCCCC1)Oc1ccc(cc1)-c1cnc2n(cnc2c1)-c1ccccc1 Show InChI InChI=1S/C25H26N4O/c1-3-7-22(8-4-1)29-19-27-24-17-21(18-26-25(24)29)20-9-11-23(12-10-20)30-16-15-28-13-5-2-6-14-28/h1,3-4,7-12,17-19H,2,5-6,13-16H2	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	37	n/a	n/a	n/a	n/a	7.4	22
Merck Research Laboratories					Assay Description Activated KDR was incubated with 25 uM/10 uCi of [gamma-33P] ATP, poly-Glu/Tyr, and inhibitors in kinase buffer for 15 min at 22 °C. The reactio...				Bioorg Med Chem Lett 13: 2485-8 (2003) Article DOI: 10.1016/s0960-894x(03)00485-2 BindingDB Entry DOI: 10.7270/Q21R6NQ2
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM5369 (5-(1-phenyl-1H-1,3-benzodiazol-5-yl)-1-[3-(piperid...) Show SMILES O=c1ccc(cn1CCCN1CCCCC1)-c1ccc2n(cnc2c1)-c1ccccc1 Show InChI InChI=1S/C26H28N4O/c31-26-13-11-22(19-29(26)17-7-16-28-14-5-2-6-15-28)21-10-12-25-24(18-21)27-20-30(25)23-8-3-1-4-9-23/h1,3-4,8-13,18-20H,2,5-7,14-17H2	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	37	n/a	n/a	n/a	n/a	7.4	22
Merck Research Laboratories					Assay Description Activated KDR was incubated with 25 uM/10 uCi of [gamma-33P] ATP, poly-Glu/Tyr, and inhibitors in kinase buffer for 15 min at 22 °C. The reactio...				Bioorg Med Chem Lett 13: 2485-8 (2003) Article DOI: 10.1016/s0960-894x(03)00485-2 BindingDB Entry DOI: 10.7270/Q21R6NQ2
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50179425 (2-(6-aminopyrimidin-4-ylamino)thiazole-5-carbonitr...) Show SMILES Nc1cc(Nc2ncc(s2)C#N)ncn1 Show InChI InChI=1S/C8H6N6S/c9-2-5-3-11-8(15-5)14-7-1-6(10)12-4-13-7/h1,3-4H,(H3,10,11,12,13,14)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	41	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of KDR				Bioorg Med Chem Lett 16: 1146-50 (2006) Article DOI: 10.1016/j.bmcl.2005.11.089 BindingDB Entry DOI: 10.7270/Q279448N
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50179416 (2-(6-(4-acetylpiperazin-1-yl)pyrimidin-4-ylamino)t...) Show SMILES CC(=O)N1CCN(CC1)c1cc(Nc2ncc(s2)C#N)ncn1 Show InChI InChI=1S/C14H15N7OS/c1-10(22)20-2-4-21(5-3-20)13-6-12(17-9-18-13)19-14-16-8-11(7-15)23-14/h6,8-9H,2-5H2,1H3,(H,16,17,18,19)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	44	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of human KDR expressed in HEK293 cells by KDR autophosphorylation assay				Bioorg Med Chem Lett 16: 1146-50 (2006) Article DOI: 10.1016/j.bmcl.2005.11.089 BindingDB Entry DOI: 10.7270/Q279448N
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM5367 (N-[2-(morpholin-4-yl)ethyl]-5-(1-phenyl-1H-1,3-ben...) Show SMILES C(CN1CCOCC1)Nc1ccc(cn1)-c1ccc2n(cnc2c1)-c1ccccc1 Show InChI InChI=1S/C24H25N5O/c1-2-4-21(5-3-1)29-18-27-22-16-19(6-8-23(22)29)20-7-9-24(26-17-20)25-10-11-28-12-14-30-15-13-28/h1-9,16-18H,10-15H2,(H,25,26)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	52	n/a	n/a	n/a	n/a	7.4	22
Merck Research Laboratories					Assay Description Activated KDR was incubated with 25 uM/10 uCi of [gamma-33P] ATP, poly-Glu/Tyr, and inhibitors in kinase buffer for 15 min at 22 °C. The reactio...				Bioorg Med Chem Lett 13: 2485-8 (2003) Article DOI: 10.1016/s0960-894x(03)00485-2 BindingDB Entry DOI: 10.7270/Q21R6NQ2
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50179413 (2-(6-(4-aminopiperidin-1-yl)pyrimidin-4-ylamino)th...) Show SMILES NC1CCN(CC1)c1cc(Nc2ncc(s2)C#N)ncn1 Show InChI InChI=1S/C13H15N7S/c14-6-10-7-16-13(21-10)19-11-5-12(18-8-17-11)20-3-1-9(15)2-4-20/h5,7-9H,1-4,15H2,(H,16,17,18,19)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	59	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of human KDR expressed in HEK293 cells by KDR autophosphorylation assay				Bioorg Med Chem Lett 16: 1146-50 (2006) Article DOI: 10.1016/j.bmcl.2005.11.089 BindingDB Entry DOI: 10.7270/Q279448N
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM5342 (N-(5-phenyl-1,3-thiazol-2-yl)benzamide | aminothia...) Show SMILES O=C(Nc1ncc(s1)-c1ccccc1)c1ccccc1 Show InChI InChI=1S/C16H12N2OS/c19-15(13-9-5-2-6-10-13)18-16-17-11-14(20-16)12-7-3-1-4-8-12/h1-11H,(H,17,18,19)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	81	n/a	n/a	n/a	n/a	7.4	22
Merck Research Laboratories					Assay Description Activated KDR was incubated with 25 uM/10 uCi of [gamma-33P] ATP, poly-Glu/Tyr, and inhibitors in kinase buffer for 15 min at 22 °C. The reactio...				Bioorg Med Chem Lett 14: 351-5 (2004) Article DOI: 10.1016/j.bmcl.2003.11.007 BindingDB Entry DOI: 10.7270/Q298856Z
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM5370 (4-(1-phenyl-1H-1,3-benzodiazol-5-yl)-1-[2-(piperid...) Show SMILES O=c1cc(ccn1CCN1CCCCC1)-c1ccc2n(cnc2c1)-c1ccccc1 Show InChI InChI=1S/C25H26N4O/c30-25-18-21(11-14-28(25)16-15-27-12-5-2-6-13-27)20-9-10-24-23(17-20)26-19-29(24)22-7-3-1-4-8-22/h1,3-4,7-11,14,17-19H,2,5-6,12-13,15-16H2	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	88	n/a	n/a	n/a	n/a	7.4	22
Merck Research Laboratories					Assay Description Activated KDR was incubated with 25 uM/10 uCi of [gamma-33P] ATP, poly-Glu/Tyr, and inhibitors in kinase buffer for 15 min at 22 °C. The reactio...				Bioorg Med Chem Lett 13: 2485-8 (2003) Article DOI: 10.1016/s0960-894x(03)00485-2 BindingDB Entry DOI: 10.7270/Q21R6NQ2
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM5372 (4-(1-phenyl-1H-1,3-benzodiazol-5-yl)-1-[3-(piperid...) Show SMILES O=c1nc(ccn1CCCN1CCCCC1)-c1ccc2n(cnc2c1)-c1ccccc1 Show InChI InChI=1S/C25H27N5O/c31-25-27-22(12-17-29(25)16-7-15-28-13-5-2-6-14-28)20-10-11-24-23(18-20)26-19-30(24)21-8-3-1-4-9-21/h1,3-4,8-12,17-19H,2,5-7,13-16H2	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	96	n/a	n/a	n/a	n/a	7.4	22
Merck Research Laboratories					Assay Description Activated KDR was incubated with 25 uM/10 uCi of [gamma-33P] ATP, poly-Glu/Tyr, and inhibitors in kinase buffer for 15 min at 22 °C. The reactio...				Bioorg Med Chem Lett 13: 2485-8 (2003) Article DOI: 10.1016/s0960-894x(03)00485-2 BindingDB Entry DOI: 10.7270/Q21R6NQ2
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM5374 (4-(1H-1,3-benzodiazol-1-yl)-N-(3-chlorophenyl)pyri...) Show SMILES Clc1cccc(Nc2nccc(n2)-n2cnc3ccccc23)c1 Show InChI InChI=1S/C17H12ClN5/c18-12-4-3-5-13(10-12)21-17-19-9-8-16(22-17)23-11-20-14-6-1-2-7-15(14)23/h1-11H,(H,19,21,22)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	113	n/a	n/a	n/a	n/a	7.4	22
Merck Research Laboratories					Assay Description Activated KDR was incubated with 25 uM/10 uCi of [gamma-33P] ATP, poly-Glu/Tyr, and inhibitors in kinase buffer for 15 min at 22 °C. The reactio...				Bioorg Med Chem Lett 13: 2485-8 (2003) Article DOI: 10.1016/s0960-894x(03)00485-2 BindingDB Entry DOI: 10.7270/Q21R6NQ2
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM5346 (5-phenyl-N-(pyrimidin-2-yl)-1,3-thiazol-2-amine | ...) Show SMILES N(c1ncc(s1)-c1ccccc1)c1ncccn1 Show InChI InChI=1S/C13H10N4S/c1-2-5-10(6-3-1)11-9-16-13(18-11)17-12-14-7-4-8-15-12/h1-9H,(H,14,15,16,17)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	137	n/a	n/a	n/a	n/a	7.4	22
Merck Research Laboratories					Assay Description Activated KDR was incubated with 25 uM/10 uCi of [gamma-33P] ATP, poly-Glu/Tyr, and inhibitors in kinase buffer for 15 min at 22 °C. The reactio...				Bioorg Med Chem Lett 14: 351-5 (2004) Article DOI: 10.1016/j.bmcl.2003.11.007 BindingDB Entry DOI: 10.7270/Q298856Z
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM5341 (N-butyl-N,3-dimethyl-4-[(E)-2-(5-nitro-1,3-thiazol...) Show SMILES CCCCN(C)c1ccc(\N=N\c2ncc(s2)[N+]([O-])=O)c(C)c1 Show InChI InChI=1S/C15H19N5O2S/c1-4-5-8-19(3)12-6-7-13(11(2)9-12)17-18-15-16-10-14(23-15)20(21)22/h6-7,9-10H,4-5,8H2,1-3H3/b18-17+	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	151	n/a	n/a	n/a	n/a	7.4	22
Merck Research Laboratories					Assay Description Activated KDR was incubated with 25 uM/10 uCi of [gamma-33P] ATP, poly-Glu/Tyr, and inhibitors in kinase buffer for 15 min at 22 °C. The reactio...				Bioorg Med Chem Lett 14: 351-5 (2004) Article DOI: 10.1016/j.bmcl.2003.11.007 BindingDB Entry DOI: 10.7270/Q298856Z
					More data for this Ligand-Target Pair

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