Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Glutathione reductase, mitochondrial (Homo sapiens (Human)) | BDBM50422689 (640/359 | CEFUROXIME) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Similars | Article PubMed | 1.04E+4 | n/a | 1.88E+4 | n/a | n/a | n/a | n/a | 8.0 | n/a |
Ondokuz Mayis University | Assay Description Enzymatic activity was measured by Beutler's method with a Shimadzu Spectrophotometer UV-(1208), at 25°C. The assay system contained 100 mM Tris-... | J Enzyme Inhib Med Chem 28: 824-9 (2013) Article DOI: 10.3109/14756366.2012.688042 BindingDB Entry DOI: 10.7270/Q21J98P4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Carbonic anhydrase 2 (Homo sapiens (Human)) | BDBM50049707 ((6R,7R)-7-{2-(2-Amino-thiazol-4-yl)-2-[(Z)-methoxy...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid UniChem Patents Similars | Article PubMed | 1.58E+4 | -27.4 | 2.10E+4 | n/a | n/a | n/a | n/a | 7.4 | 25 |
Erzincan University | Assay Description CA activity was assayed according to method of Verpoorte et al. [Verpoorte et al., J. Biol. Chem., 242:4221-4229] described previously by Innocenti e... | J Enzyme Inhib Med Chem 27: 641-5 (2012) Article DOI: 10.3109/14756366.2011.604852 BindingDB Entry DOI: 10.7270/Q2WH2NXK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glutathione reductase, mitochondrial (Homo sapiens (Human)) | BDBM50049707 ((6R,7R)-7-{2-(2-Amino-thiazol-4-yl)-2-[(Z)-methoxy...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid UniChem Patents Similars | Article PubMed | 1.73E+4 | n/a | 2.13E+4 | n/a | n/a | n/a | n/a | 8.0 | n/a |
Ondokuz Mayis University | Assay Description Enzymatic activity was measured by Beutler's method with a Shimadzu Spectrophotometer UV-(1208), at 25°C. The assay system contained 100 mM Tris-... | J Enzyme Inhib Med Chem 28: 824-9 (2013) Article DOI: 10.3109/14756366.2012.688042 BindingDB Entry DOI: 10.7270/Q21J98P4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glutathione reductase, mitochondrial (Homo sapiens (Human)) | BDBM237182 (Ceftizoxime) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase DrugBank MCE KEGG PC cid PC sid UniChem | Article PubMed | 2.28E+4 | n/a | 3.97E+4 | n/a | n/a | n/a | n/a | 8.0 | n/a |
Ondokuz Mayis University | Assay Description Enzymatic activity was measured by Beutler's method with a Shimadzu Spectrophotometer UV-(1208), at 25°C. The assay system contained 100 mM Tris-... | J Enzyme Inhib Med Chem 28: 824-9 (2013) Article DOI: 10.3109/14756366.2012.688042 BindingDB Entry DOI: 10.7270/Q21J98P4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Carbonic anhydrase 1 (Homo sapiens (Human)) | BDBM50049707 ((6R,7R)-7-{2-(2-Amino-thiazol-4-yl)-2-[(Z)-methoxy...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid UniChem Patents Similars | Article PubMed | 2.85E+4 | -25.9 | 2.71E+4 | n/a | n/a | n/a | n/a | 7.4 | 25 |
Erzincan University | Assay Description CA activity was assayed according to method of Verpoorte et al. [Verpoorte et al., J. Biol. Chem., 242:4221-4229] described previously by Innocenti e... | J Enzyme Inhib Med Chem 27: 641-5 (2012) Article DOI: 10.3109/14756366.2011.604852 BindingDB Entry DOI: 10.7270/Q2WH2NXK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glutathione reductase, mitochondrial (Homo sapiens (Human)) | BDBM50390999 (CEFOPERAZONE) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase MCE KEGG PC cid PC sid UniChem Similars | Article PubMed | 2.87E+4 | n/a | 4.84E+4 | n/a | n/a | n/a | n/a | 8.0 | n/a |
Ondokuz Mayis University | Assay Description Enzymatic activity was measured by Beutler's method with a Shimadzu Spectrophotometer UV-(1208), at 25°C. The assay system contained 100 mM Tris-... | J Enzyme Inhib Med Chem 28: 824-9 (2013) Article DOI: 10.3109/14756366.2012.688042 BindingDB Entry DOI: 10.7270/Q21J98P4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Carbonic anhydrase 2 (Homo sapiens (Human)) | BDBM237183 (Ranitidine) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase DrugBank MCE PC cid PC sid UniChem | Article PubMed | 2.97E+4 | -25.8 | 6.61E+4 | n/a | n/a | n/a | n/a | 7.4 | 25 |
Erzincan University | Assay Description CA activity was assayed according to method of Verpoorte et al. [Verpoorte et al., J. Biol. Chem., 242:4221-4229] described previously by Innocenti e... | J Enzyme Inhib Med Chem 27: 641-5 (2012) Article DOI: 10.3109/14756366.2011.604852 BindingDB Entry DOI: 10.7270/Q2WH2NXK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Microsomal glutathione S-transferase 1 (Homo sapiens (Human)) | BDBM50422689 (640/359 | CEFUROXIME) | UniProtKB/SwissProt GoogleScholar AffyNet | Purchase DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Similars | Article PubMed | 3.24E+4 | n/a | 5.64E+4 | n/a | n/a | n/a | n/a | 6.5 | n/a |
Ondokuz Mayis University | Assay Description Enzymatic activity was determined spectrophotometrically by measuring the conjugation of CDNB with GSH. The 1 ml assay mixture contained 0.5 mM CDNB,... | J Enzyme Inhib Med Chem 28: 824-9 (2013) Article DOI: 10.3109/14756366.2012.688042 BindingDB Entry DOI: 10.7270/Q21J98P4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glutathione peroxidase 1 (Homo sapiens (Human)) | BDBM50422689 (640/359 | CEFUROXIME) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Similars | Article PubMed | 3.27E+4 | n/a | 4.43E+4 | n/a | n/a | n/a | n/a | 7.0 | n/a |
Ondokuz Mayis University | Assay Description Glutathione peroxidase was assayed in a l-ml system containing 0.1 M potassium phosphate buffer, pH 7.0, 0.2 mM NADPH, 1 i.u. glutathione reductase, ... | J Enzyme Inhib Med Chem 28: 824-9 (2013) Article DOI: 10.3109/14756366.2012.688042 BindingDB Entry DOI: 10.7270/Q21J98P4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glutathione peroxidase 1 (Homo sapiens (Human)) | BDBM50049707 ((6R,7R)-7-{2-(2-Amino-thiazol-4-yl)-2-[(Z)-methoxy...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid UniChem Patents Similars | Article PubMed | 3.41E+4 | n/a | 4.86E+4 | n/a | n/a | n/a | n/a | 7.0 | n/a |
Ondokuz Mayis University | Assay Description Glutathione peroxidase was assayed in a l-ml system containing 0.1 M potassium phosphate buffer, pH 7.0, 0.2 mM NADPH, 1 i.u. glutathione reductase, ... | J Enzyme Inhib Med Chem 28: 824-9 (2013) Article DOI: 10.3109/14756366.2012.688042 BindingDB Entry DOI: 10.7270/Q21J98P4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Microsomal glutathione S-transferase 1 (Homo sapiens (Human)) | BDBM50049707 ((6R,7R)-7-{2-(2-Amino-thiazol-4-yl)-2-[(Z)-methoxy...) | UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid UniChem Patents Similars | Article PubMed | 3.54E+4 | n/a | 6.18E+4 | n/a | n/a | n/a | n/a | 6.5 | n/a |
Ondokuz Mayis University | Assay Description Enzymatic activity was determined spectrophotometrically by measuring the conjugation of CDNB with GSH. The 1 ml assay mixture contained 0.5 mM CDNB,... | J Enzyme Inhib Med Chem 28: 824-9 (2013) Article DOI: 10.3109/14756366.2012.688042 BindingDB Entry DOI: 10.7270/Q21J98P4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Carbonic anhydrase 2 (Homo sapiens (Human)) | BDBM237182 (Ceftizoxime) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase DrugBank MCE KEGG PC cid PC sid UniChem | Article PubMed | 5.18E+4 | -24.5 | 7.91E+4 | n/a | n/a | n/a | n/a | 7.4 | 25 |
Erzincan University | Assay Description CA activity was assayed according to method of Verpoorte et al. [Verpoorte et al., J. Biol. Chem., 242:4221-4229] described previously by Innocenti e... | J Enzyme Inhib Med Chem 27: 641-5 (2012) Article DOI: 10.3109/14756366.2011.604852 BindingDB Entry DOI: 10.7270/Q2WH2NXK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Carbonic anhydrase 1 (Homo sapiens (Human)) | BDBM237183 (Ranitidine) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase DrugBank MCE PC cid PC sid UniChem | Article PubMed | 5.47E+4 | -24.3 | 5.55E+4 | n/a | n/a | n/a | n/a | 7.4 | 25 |
Erzincan University | Assay Description CA activity was assayed according to method of Verpoorte et al. [Verpoorte et al., J. Biol. Chem., 242:4221-4229] described previously by Innocenti e... | J Enzyme Inhib Med Chem 27: 641-5 (2012) Article DOI: 10.3109/14756366.2011.604852 BindingDB Entry DOI: 10.7270/Q2WH2NXK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Carbonic anhydrase 2 (Homo sapiens (Human)) | BDBM50350465 (AMPICILLIN | AY-6108 | Amcill | Aminobenzylpenicil...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | 8.30E+4 | -23.3 | 5.68E+4 | n/a | n/a | n/a | n/a | 7.4 | 25 |
Erzincan University | Assay Description CA activity was assayed according to method of Verpoorte et al. [Verpoorte et al., J. Biol. Chem., 242:4221-4229] described previously by Innocenti e... | J Enzyme Inhib Med Chem 27: 641-5 (2012) Article DOI: 10.3109/14756366.2011.604852 BindingDB Entry DOI: 10.7270/Q2WH2NXK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Carbonic anhydrase 1 (Homo sapiens (Human)) | BDBM237182 (Ceftizoxime) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase DrugBank MCE KEGG PC cid PC sid UniChem | Article PubMed | 8.61E+4 | -23.2 | 7.94E+4 | n/a | n/a | n/a | n/a | 7.4 | 25 |
Erzincan University | Assay Description CA activity was assayed according to method of Verpoorte et al. [Verpoorte et al., J. Biol. Chem., 242:4221-4229] described previously by Innocenti e... | J Enzyme Inhib Med Chem 27: 641-5 (2012) Article DOI: 10.3109/14756366.2011.604852 BindingDB Entry DOI: 10.7270/Q2WH2NXK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glutathione peroxidase 1 (Homo sapiens (Human)) | BDBM237182 (Ceftizoxime) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase DrugBank MCE KEGG PC cid PC sid UniChem | Article PubMed | 1.21E+5 | n/a | 1.86E+5 | n/a | n/a | n/a | n/a | 7.0 | n/a |
Ondokuz Mayis University | Assay Description Glutathione peroxidase was assayed in a l-ml system containing 0.1 M potassium phosphate buffer, pH 7.0, 0.2 mM NADPH, 1 i.u. glutathione reductase, ... | J Enzyme Inhib Med Chem 28: 824-9 (2013) Article DOI: 10.3109/14756366.2012.688042 BindingDB Entry DOI: 10.7270/Q21J98P4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Microsomal glutathione S-transferase 1 (Homo sapiens (Human)) | BDBM237182 (Ceftizoxime) | UniProtKB/SwissProt GoogleScholar AffyNet | Purchase DrugBank MCE KEGG PC cid PC sid UniChem | Article PubMed | 1.65E+5 | n/a | 2.78E+5 | n/a | n/a | n/a | n/a | 6.5 | n/a |
Ondokuz Mayis University | Assay Description Enzymatic activity was determined spectrophotometrically by measuring the conjugation of CDNB with GSH. The 1 ml assay mixture contained 0.5 mM CDNB,... | J Enzyme Inhib Med Chem 28: 824-9 (2013) Article DOI: 10.3109/14756366.2012.688042 BindingDB Entry DOI: 10.7270/Q21J98P4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glutathione peroxidase 1 (Homo sapiens (Human)) | BDBM50390999 (CEFOPERAZONE) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase MCE KEGG PC cid PC sid UniChem Similars | Article PubMed | 2.45E+5 | n/a | 3.13E+5 | n/a | n/a | n/a | n/a | 7.0 | n/a |
Ondokuz Mayis University | Assay Description Glutathione peroxidase was assayed in a l-ml system containing 0.1 M potassium phosphate buffer, pH 7.0, 0.2 mM NADPH, 1 i.u. glutathione reductase, ... | J Enzyme Inhib Med Chem 28: 824-9 (2013) Article DOI: 10.3109/14756366.2012.688042 BindingDB Entry DOI: 10.7270/Q21J98P4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Microsomal glutathione S-transferase 1 (Homo sapiens (Human)) | BDBM50390999 (CEFOPERAZONE) | UniProtKB/SwissProt GoogleScholar AffyNet | Purchase MCE KEGG PC cid PC sid UniChem Similars | Article PubMed | 2.67E+5 | n/a | 4.84E+5 | n/a | n/a | n/a | n/a | 6.5 | n/a |
Ondokuz Mayis University | Assay Description Enzymatic activity was determined spectrophotometrically by measuring the conjugation of CDNB with GSH. The 1 ml assay mixture contained 0.5 mM CDNB,... | J Enzyme Inhib Med Chem 28: 824-9 (2013) Article DOI: 10.3109/14756366.2012.688042 BindingDB Entry DOI: 10.7270/Q21J98P4 | |||||||||||
More data for this Ligand-Target Pair |