Compile Data Set for Download or QSAR

Found 510 hits with Last Name = 'demestre' and Initial = 'cg'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha (Homo sapiens (Human))	BDBM288386 (US10087187, Compound 81) Show SMILES CCC(C)C(N)C(=O)OCc1nc2c(N)cc(nn2c1Nc1cccc(c1C)C(F)(F)F)N1CCOCC1 Show InChI InChI=1S/C25H32F3N7O3/c1-4-14(2)21(30)24(36)38-13-19-23(31-18-7-5-6-16(15(18)3)25(26,27)28)35-22(32-19)17(29)12-20(33-35)34-8-10-37-11-9-34/h5-7,12,14,21,31H,4,8-11,13,29-30H2,1-3H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	KEGG PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	2.69E+4	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description Kinase enzyme binding affinities of compounds disclosed herein were determined using the KINOMEscan technology performed by DiscoveRx Corporation, Sa...				US Patent US10087187 (2018) BindingDB Entry DOI: 10.7270/Q2M61N9J
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Homo sapiens (Human))	BDBM288386 (US10087187, Compound 81) Show SMILES CCC(C)C(N)C(=O)OCc1nc2c(N)cc(nn2c1Nc1cccc(c1C)C(F)(F)F)N1CCOCC1 Show InChI InChI=1S/C25H32F3N7O3/c1-4-14(2)21(30)24(36)38-13-19-23(31-18-7-5-6-16(15(18)3)25(26,27)28)35-22(32-19)17(29)12-20(33-35)34-8-10-37-11-9-34/h5-7,12,14,21,31H,4,8-11,13,29-30H2,1-3H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	KEGG PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	724	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description Kinase enzyme binding affinities of compounds disclosed herein were determined using the KINOMEscan technology performed by DiscoveRx Corporation, Sa...				US Patent US10087187 (2018) BindingDB Entry DOI: 10.7270/Q2M61N9J
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (Homo sapiens (Human))	BDBM288386 (US10087187, Compound 81) Show SMILES CCC(C)C(N)C(=O)OCc1nc2c(N)cc(nn2c1Nc1cccc(c1C)C(F)(F)F)N1CCOCC1 Show InChI InChI=1S/C25H32F3N7O3/c1-4-14(2)21(30)24(36)38-13-19-23(31-18-7-5-6-16(15(18)3)25(26,27)28)35-22(32-19)17(29)12-20(33-35)34-8-10-37-11-9-34/h5-7,12,14,21,31H,4,8-11,13,29-30H2,1-3H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	KEGG PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	>3.02E+4	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description Kinase enzyme binding affinities of compounds disclosed herein were determined using the KINOMEscan technology performed by DiscoveRx Corporation, Sa...				US Patent US10087187 (2018) BindingDB Entry DOI: 10.7270/Q2M61N9J
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase mTOR (Homo sapiens (Human))	BDBM288386 (US10087187, Compound 81) Show SMILES CCC(C)C(N)C(=O)OCc1nc2c(N)cc(nn2c1Nc1cccc(c1C)C(F)(F)F)N1CCOCC1 Show InChI InChI=1S/C25H32F3N7O3/c1-4-14(2)21(30)24(36)38-13-19-23(31-18-7-5-6-16(15(18)3)25(26,27)28)35-22(32-19)17(29)12-20(33-35)34-8-10-37-11-9-34/h5-7,12,14,21,31H,4,8-11,13,29-30H2,1-3H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	KEGG PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	>3.02E+4	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description Kinase enzyme binding affinities of compounds disclosed herein were determined using the KINOMEscan technology performed by DiscoveRx Corporation, Sa...				US Patent US10087187 (2018) BindingDB Entry DOI: 10.7270/Q2M61N9J
					More data for this Ligand-Target Pair
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha (Homo sapiens (Human))	BDBM288387 (US10087187, Compound 82) Show SMILES CC(C)C(N)C(=O)OCc1nc2c(N)cc(nn2c1Nc1cccc(c1C)C(F)(F)F)N1CCOCC1 Show InChI InChI=1S/C24H30F3N7O3/c1-13(2)20(29)23(35)37-12-18-22(30-17-6-4-5-15(14(17)3)24(25,26)27)34-21(31-18)16(28)11-19(32-34)33-7-9-36-10-8-33/h4-6,11,13,20,30H,7-10,12,28-29H2,1-3H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	KEGG PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	3.24E+4	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description Kinase enzyme binding affinities of compounds disclosed herein were determined using the KINOMEscan technology performed by DiscoveRx Corporation, Sa...				US Patent US10087187 (2018) BindingDB Entry DOI: 10.7270/Q2M61N9J
					More data for this Ligand-Target Pair
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta (Homo sapiens (Human))	BDBM288387 (US10087187, Compound 82) Show SMILES CC(C)C(N)C(=O)OCc1nc2c(N)cc(nn2c1Nc1cccc(c1C)C(F)(F)F)N1CCOCC1 Show InChI InChI=1S/C24H30F3N7O3/c1-13(2)20(29)23(35)37-12-18-22(30-17-6-4-5-15(14(17)3)24(25,26)27)34-21(31-18)16(28)11-19(32-34)33-7-9-36-10-8-33/h4-6,11,13,20,30H,7-10,12,28-29H2,1-3H3	NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	KEGG PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	1.30	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description Kinase enzyme binding affinities of compounds disclosed herein were determined using the KINOMEscan technology performed by DiscoveRx Corporation, Sa...				US Patent US10087187 (2018) BindingDB Entry DOI: 10.7270/Q2M61N9J
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Homo sapiens (Human))	BDBM288387 (US10087187, Compound 82) Show SMILES CC(C)C(N)C(=O)OCc1nc2c(N)cc(nn2c1Nc1cccc(c1C)C(F)(F)F)N1CCOCC1 Show InChI InChI=1S/C24H30F3N7O3/c1-13(2)20(29)23(35)37-12-18-22(30-17-6-4-5-15(14(17)3)24(25,26)27)34-21(31-18)16(28)11-19(32-34)33-7-9-36-10-8-33/h4-6,11,13,20,30H,7-10,12,28-29H2,1-3H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	KEGG PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	263	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description Kinase enzyme binding affinities of compounds disclosed herein were determined using the KINOMEscan technology performed by DiscoveRx Corporation, Sa...				US Patent US10087187 (2018) BindingDB Entry DOI: 10.7270/Q2M61N9J
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (Homo sapiens (Human))	BDBM288387 (US10087187, Compound 82) Show SMILES CC(C)C(N)C(=O)OCc1nc2c(N)cc(nn2c1Nc1cccc(c1C)C(F)(F)F)N1CCOCC1 Show InChI InChI=1S/C24H30F3N7O3/c1-13(2)20(29)23(35)37-12-18-22(30-17-6-4-5-15(14(17)3)24(25,26)27)34-21(31-18)16(28)11-19(32-34)33-7-9-36-10-8-33/h4-6,11,13,20,30H,7-10,12,28-29H2,1-3H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	KEGG PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	>3.02E+4	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description Kinase enzyme binding affinities of compounds disclosed herein were determined using the KINOMEscan technology performed by DiscoveRx Corporation, Sa...				US Patent US10087187 (2018) BindingDB Entry DOI: 10.7270/Q2M61N9J
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase mTOR (Homo sapiens (Human))	BDBM288387 (US10087187, Compound 82) Show SMILES CC(C)C(N)C(=O)OCc1nc2c(N)cc(nn2c1Nc1cccc(c1C)C(F)(F)F)N1CCOCC1 Show InChI InChI=1S/C24H30F3N7O3/c1-13(2)20(29)23(35)37-12-18-22(30-17-6-4-5-15(14(17)3)24(25,26)27)34-21(31-18)16(28)11-19(32-34)33-7-9-36-10-8-33/h4-6,11,13,20,30H,7-10,12,28-29H2,1-3H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	KEGG PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	2.51E+4	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description Kinase enzyme binding affinities of compounds disclosed herein were determined using the KINOMEscan technology performed by DiscoveRx Corporation, Sa...				US Patent US10087187 (2018) BindingDB Entry DOI: 10.7270/Q2M61N9J
					More data for this Ligand-Target Pair
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha (Homo sapiens (Human))	BDBM288388 (US10087187, Compound 83) Show SMILES Cc1c(Nc2c(COC(=O)C3(CC3)NC(=O)OC(C)(C)C)nc3c(N)cc(nn23)N2CCOCC2)cccc1C(F)(F)F Show InChI InChI=1S/C28H34F3N7O5/c1-16-17(28(29,30)31)6-5-7-19(16)33-23-20(15-42-24(39)27(8-9-27)35-25(40)43-26(2,3)4)34-22-18(32)14-21(36-38(22)23)37-10-12-41-13-11-37/h5-7,14,33H,8-13,15,32H2,1-4H3,(H,35,40)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	2.22E+4	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description Kinase enzyme binding affinities of compounds disclosed herein were determined using the KINOMEscan technology performed by DiscoveRx Corporation, Sa...				US Patent US10087187 (2018) BindingDB Entry DOI: 10.7270/Q2M61N9J
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Homo sapiens (Human))	BDBM288388 (US10087187, Compound 83) Show SMILES Cc1c(Nc2c(COC(=O)C3(CC3)NC(=O)OC(C)(C)C)nc3c(N)cc(nn23)N2CCOCC2)cccc1C(F)(F)F Show InChI InChI=1S/C28H34F3N7O5/c1-16-17(28(29,30)31)6-5-7-19(16)33-23-20(15-42-24(39)27(8-9-27)35-25(40)43-26(2,3)4)34-22-18(32)14-21(36-38(22)23)37-10-12-41-13-11-37/h5-7,14,33H,8-13,15,32H2,1-4H3,(H,35,40)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	309	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description Kinase enzyme binding affinities of compounds disclosed herein were determined using the KINOMEscan technology performed by DiscoveRx Corporation, Sa...				US Patent US10087187 (2018) BindingDB Entry DOI: 10.7270/Q2M61N9J
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (Homo sapiens (Human))	BDBM288388 (US10087187, Compound 83) Show SMILES Cc1c(Nc2c(COC(=O)C3(CC3)NC(=O)OC(C)(C)C)nc3c(N)cc(nn23)N2CCOCC2)cccc1C(F)(F)F Show InChI InChI=1S/C28H34F3N7O5/c1-16-17(28(29,30)31)6-5-7-19(16)33-23-20(15-42-24(39)27(8-9-27)35-25(40)43-26(2,3)4)34-22-18(32)14-21(36-38(22)23)37-10-12-41-13-11-37/h5-7,14,33H,8-13,15,32H2,1-4H3,(H,35,40)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	>3.02E+4	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description Kinase enzyme binding affinities of compounds disclosed herein were determined using the KINOMEscan technology performed by DiscoveRx Corporation, Sa...				US Patent US10087187 (2018) BindingDB Entry DOI: 10.7270/Q2M61N9J
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase mTOR (Homo sapiens (Human))	BDBM288388 (US10087187, Compound 83) Show SMILES Cc1c(Nc2c(COC(=O)C3(CC3)NC(=O)OC(C)(C)C)nc3c(N)cc(nn23)N2CCOCC2)cccc1C(F)(F)F Show InChI InChI=1S/C28H34F3N7O5/c1-16-17(28(29,30)31)6-5-7-19(16)33-23-20(15-42-24(39)27(8-9-27)35-25(40)43-26(2,3)4)34-22-18(32)14-21(36-38(22)23)37-10-12-41-13-11-37/h5-7,14,33H,8-13,15,32H2,1-4H3,(H,35,40)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	>2.83E+4	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description Kinase enzyme binding affinities of compounds disclosed herein were determined using the KINOMEscan technology performed by DiscoveRx Corporation, Sa...				US Patent US10087187 (2018) BindingDB Entry DOI: 10.7270/Q2M61N9J
					More data for this Ligand-Target Pair
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha (Homo sapiens (Human))	BDBM288384 (US10087187, Compound 79 | US10087187, Compound 84) Show SMILES CC(N)C(=O)OCc1nc2c(N)cc(nn2c1Nc1cccc(c1C)C(F)(F)F)N1CCOCC1 Show InChI InChI=1S/C22H26F3N7O3/c1-12-14(22(23,24)25)4-3-5-16(12)28-20-17(11-35-21(33)13(2)26)29-19-15(27)10-18(30-32(19)20)31-6-8-34-9-7-31/h3-5,10,13,28H,6-9,11,26-27H2,1-2H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	KEGG PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	1.20E+4	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description Kinase enzyme binding affinities of compounds disclosed herein were determined using the KINOMEscan technology performed by DiscoveRx Corporation, Sa...				US Patent US10087187 (2018) BindingDB Entry DOI: 10.7270/Q2M61N9J
					More data for this Ligand-Target Pair
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta (Homo sapiens (Human))	BDBM288384 (US10087187, Compound 79 | US10087187, Compound 84) Show SMILES CC(N)C(=O)OCc1nc2c(N)cc(nn2c1Nc1cccc(c1C)C(F)(F)F)N1CCOCC1 Show InChI InChI=1S/C22H26F3N7O3/c1-12-14(22(23,24)25)4-3-5-16(12)28-20-17(11-35-21(33)13(2)26)29-19-15(27)10-18(30-32(19)20)31-6-8-34-9-7-31/h3-5,10,13,28H,6-9,11,26-27H2,1-2H3	NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	KEGG PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	0.5	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description Kinase enzyme binding affinities of compounds disclosed herein were determined using the KINOMEscan technology performed by DiscoveRx Corporation, Sa...				US Patent US10087187 (2018) BindingDB Entry DOI: 10.7270/Q2M61N9J
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Homo sapiens (Human))	BDBM288384 (US10087187, Compound 79 | US10087187, Compound 84) Show SMILES CC(N)C(=O)OCc1nc2c(N)cc(nn2c1Nc1cccc(c1C)C(F)(F)F)N1CCOCC1 Show InChI InChI=1S/C22H26F3N7O3/c1-12-14(22(23,24)25)4-3-5-16(12)28-20-17(11-35-21(33)13(2)26)29-19-15(27)10-18(30-32(19)20)31-6-8-34-9-7-31/h3-5,10,13,28H,6-9,11,26-27H2,1-2H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	KEGG PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	48	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description Kinase enzyme binding affinities of compounds disclosed herein were determined using the KINOMEscan technology performed by DiscoveRx Corporation, Sa...				US Patent US10087187 (2018) BindingDB Entry DOI: 10.7270/Q2M61N9J
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (Homo sapiens (Human))	BDBM288384 (US10087187, Compound 79 | US10087187, Compound 84) Show SMILES CC(N)C(=O)OCc1nc2c(N)cc(nn2c1Nc1cccc(c1C)C(F)(F)F)N1CCOCC1 Show InChI InChI=1S/C22H26F3N7O3/c1-12-14(22(23,24)25)4-3-5-16(12)28-20-17(11-35-21(33)13(2)26)29-19-15(27)10-18(30-32(19)20)31-6-8-34-9-7-31/h3-5,10,13,28H,6-9,11,26-27H2,1-2H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	KEGG PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	1.26E+4	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description Kinase enzyme binding affinities of compounds disclosed herein were determined using the KINOMEscan technology performed by DiscoveRx Corporation, Sa...				US Patent US10087187 (2018) BindingDB Entry DOI: 10.7270/Q2M61N9J
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase mTOR (Homo sapiens (Human))	BDBM288384 (US10087187, Compound 79 | US10087187, Compound 84) Show SMILES CC(N)C(=O)OCc1nc2c(N)cc(nn2c1Nc1cccc(c1C)C(F)(F)F)N1CCOCC1 Show InChI InChI=1S/C22H26F3N7O3/c1-12-14(22(23,24)25)4-3-5-16(12)28-20-17(11-35-21(33)13(2)26)29-19-15(27)10-18(30-32(19)20)31-6-8-34-9-7-31/h3-5,10,13,28H,6-9,11,26-27H2,1-2H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	KEGG PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	7.94E+3	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description Kinase enzyme binding affinities of compounds disclosed herein were determined using the KINOMEscan technology performed by DiscoveRx Corporation, Sa...				US Patent US10087187 (2018) BindingDB Entry DOI: 10.7270/Q2M61N9J
					More data for this Ligand-Target Pair
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha (Homo sapiens (Human))	BDBM288390 (US10087187, Compound 85) Show SMILES Cc1c(Nc2c(CN)nc3c(N)cc(nn23)N2CCOCC2)cccc1C(F)(F)F Show InChI InChI=1S/C19H22F3N7O/c1-11-12(19(20,21)22)3-2-4-14(11)25-18-15(10-23)26-17-13(24)9-16(27-29(17)18)28-5-7-30-8-6-28/h2-4,9,25H,5-8,10,23-24H2,1H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	>2.30E+4	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description Kinase enzyme binding affinities of compounds disclosed herein were determined using the KINOMEscan technology performed by DiscoveRx Corporation, Sa...				US Patent US10087187 (2018) BindingDB Entry DOI: 10.7270/Q2M61N9J
					More data for this Ligand-Target Pair
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta (Homo sapiens (Human))	BDBM288390 (US10087187, Compound 85) Show SMILES Cc1c(Nc2c(CN)nc3c(N)cc(nn23)N2CCOCC2)cccc1C(F)(F)F Show InChI InChI=1S/C19H22F3N7O/c1-11-12(19(20,21)22)3-2-4-14(11)25-18-15(10-23)26-17-13(24)9-16(27-29(17)18)28-5-7-30-8-6-28/h2-4,9,25H,5-8,10,23-24H2,1H3	NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	0.700	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description Kinase enzyme binding affinities of compounds disclosed herein were determined using the KINOMEscan technology performed by DiscoveRx Corporation, Sa...				US Patent US10087187 (2018) BindingDB Entry DOI: 10.7270/Q2M61N9J
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Homo sapiens (Human))	BDBM288390 (US10087187, Compound 85) Show SMILES Cc1c(Nc2c(CN)nc3c(N)cc(nn23)N2CCOCC2)cccc1C(F)(F)F Show InChI InChI=1S/C19H22F3N7O/c1-11-12(19(20,21)22)3-2-4-14(11)25-18-15(10-23)26-17-13(24)9-16(27-29(17)18)28-5-7-30-8-6-28/h2-4,9,25H,5-8,10,23-24H2,1H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	75	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description Kinase enzyme binding affinities of compounds disclosed herein were determined using the KINOMEscan technology performed by DiscoveRx Corporation, Sa...				US Patent US10087187 (2018) BindingDB Entry DOI: 10.7270/Q2M61N9J
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase mTOR (Homo sapiens (Human))	BDBM288390 (US10087187, Compound 85) Show SMILES Cc1c(Nc2c(CN)nc3c(N)cc(nn23)N2CCOCC2)cccc1C(F)(F)F Show InChI InChI=1S/C19H22F3N7O/c1-11-12(19(20,21)22)3-2-4-14(11)25-18-15(10-23)26-17-13(24)9-16(27-29(17)18)28-5-7-30-8-6-28/h2-4,9,25H,5-8,10,23-24H2,1H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	2.68E+3	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description Kinase enzyme binding affinities of compounds disclosed herein were determined using the KINOMEscan technology performed by DiscoveRx Corporation, Sa...				US Patent US10087187 (2018) BindingDB Entry DOI: 10.7270/Q2M61N9J
					More data for this Ligand-Target Pair
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha (Homo sapiens (Human))	BDBM288391 (US10087187, Compound 86) Show SMILES Cc1nc2c(cc(nn2c1Nc1ccccc1N1CCOCC1)N1CCOCC1)C(O)=O Show InChI InChI=1S/C22H26N6O4/c1-15-20(24-17-4-2-3-5-18(17)26-6-10-31-11-7-26)28-21(23-15)16(22(29)30)14-19(25-28)27-8-12-32-13-9-27/h2-5,14,24H,6-13H2,1H3,(H,29,30)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	1.78E+3	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description Kinase enzyme binding affinities of compounds disclosed herein were determined using the KINOMEscan technology performed by DiscoveRx Corporation, Sa...				US Patent US10087187 (2018) BindingDB Entry DOI: 10.7270/Q2M61N9J
					More data for this Ligand-Target Pair
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta (Homo sapiens (Human))	BDBM288391 (US10087187, Compound 86) Show SMILES Cc1nc2c(cc(nn2c1Nc1ccccc1N1CCOCC1)N1CCOCC1)C(O)=O Show InChI InChI=1S/C22H26N6O4/c1-15-20(24-17-4-2-3-5-18(17)26-6-10-31-11-7-26)28-21(23-15)16(22(29)30)14-19(25-28)27-8-12-32-13-9-27/h2-5,14,24H,6-13H2,1H3,(H,29,30)	NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description Kinase enzyme binding affinities of compounds disclosed herein were determined using the KINOMEscan technology performed by DiscoveRx Corporation, Sa...				US Patent US10087187 (2018) BindingDB Entry DOI: 10.7270/Q2M61N9J
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Homo sapiens (Human))	BDBM288391 (US10087187, Compound 86) Show SMILES Cc1nc2c(cc(nn2c1Nc1ccccc1N1CCOCC1)N1CCOCC1)C(O)=O Show InChI InChI=1S/C22H26N6O4/c1-15-20(24-17-4-2-3-5-18(17)26-6-10-31-11-7-26)28-21(23-15)16(22(29)30)14-19(25-28)27-8-12-32-13-9-27/h2-5,14,24H,6-13H2,1H3,(H,29,30)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	117	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description Kinase enzyme binding affinities of compounds disclosed herein were determined using the KINOMEscan technology performed by DiscoveRx Corporation, Sa...				US Patent US10087187 (2018) BindingDB Entry DOI: 10.7270/Q2M61N9J
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (Homo sapiens (Human))	BDBM288391 (US10087187, Compound 86) Show SMILES Cc1nc2c(cc(nn2c1Nc1ccccc1N1CCOCC1)N1CCOCC1)C(O)=O Show InChI InChI=1S/C22H26N6O4/c1-15-20(24-17-4-2-3-5-18(17)26-6-10-31-11-7-26)28-21(23-15)16(22(29)30)14-19(25-28)27-8-12-32-13-9-27/h2-5,14,24H,6-13H2,1H3,(H,29,30)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	1.32E+4	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description Kinase enzyme binding affinities of compounds disclosed herein were determined using the KINOMEscan technology performed by DiscoveRx Corporation, Sa...				US Patent US10087187 (2018) BindingDB Entry DOI: 10.7270/Q2M61N9J
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase mTOR (Homo sapiens (Human))	BDBM288391 (US10087187, Compound 86) Show SMILES Cc1nc2c(cc(nn2c1Nc1ccccc1N1CCOCC1)N1CCOCC1)C(O)=O Show InChI InChI=1S/C22H26N6O4/c1-15-20(24-17-4-2-3-5-18(17)26-6-10-31-11-7-26)28-21(23-15)16(22(29)30)14-19(25-28)27-8-12-32-13-9-27/h2-5,14,24H,6-13H2,1H3,(H,29,30)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	1.95E+4	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description Kinase enzyme binding affinities of compounds disclosed herein were determined using the KINOMEscan technology performed by DiscoveRx Corporation, Sa...				US Patent US10087187 (2018) BindingDB Entry DOI: 10.7270/Q2M61N9J
					More data for this Ligand-Target Pair
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha (Homo sapiens (Human))	BDBM288392 (US10087187, Compound 87) Show SMILES Cc1nc2c(cc(nn2c1Nc1ccccc1N1CCOCC1)N1CCOCC1)C(N)=O Show InChI InChI=1S/C22H27N7O3/c1-15-21(25-17-4-2-3-5-18(17)27-6-10-31-11-7-27)29-22(24-15)16(20(23)30)14-19(26-29)28-8-12-32-13-9-28/h2-5,14,25H,6-13H2,1H3,(H2,23,30)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	1.20E+3	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description Kinase enzyme binding affinities of compounds disclosed herein were determined using the KINOMEscan technology performed by DiscoveRx Corporation, Sa...				US Patent US10087187 (2018) BindingDB Entry DOI: 10.7270/Q2M61N9J
					More data for this Ligand-Target Pair
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta (Homo sapiens (Human))	BDBM288392 (US10087187, Compound 87) Show SMILES Cc1nc2c(cc(nn2c1Nc1ccccc1N1CCOCC1)N1CCOCC1)C(N)=O Show InChI InChI=1S/C22H27N7O3/c1-15-21(25-17-4-2-3-5-18(17)27-6-10-31-11-7-27)29-22(24-15)16(20(23)30)14-19(26-29)28-8-12-32-13-9-28/h2-5,14,25H,6-13H2,1H3,(H2,23,30)	NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	43	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description Kinase enzyme binding affinities of compounds disclosed herein were determined using the KINOMEscan technology performed by DiscoveRx Corporation, Sa...				US Patent US10087187 (2018) BindingDB Entry DOI: 10.7270/Q2M61N9J
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Homo sapiens (Human))	BDBM288392 (US10087187, Compound 87) Show SMILES Cc1nc2c(cc(nn2c1Nc1ccccc1N1CCOCC1)N1CCOCC1)C(N)=O Show InChI InChI=1S/C22H27N7O3/c1-15-21(25-17-4-2-3-5-18(17)27-6-10-31-11-7-27)29-22(24-15)16(20(23)30)14-19(26-29)28-8-12-32-13-9-28/h2-5,14,25H,6-13H2,1H3,(H2,23,30)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	219	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description Kinase enzyme binding affinities of compounds disclosed herein were determined using the KINOMEscan technology performed by DiscoveRx Corporation, Sa...				US Patent US10087187 (2018) BindingDB Entry DOI: 10.7270/Q2M61N9J
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (Homo sapiens (Human))	BDBM288392 (US10087187, Compound 87) Show SMILES Cc1nc2c(cc(nn2c1Nc1ccccc1N1CCOCC1)N1CCOCC1)C(N)=O Show InChI InChI=1S/C22H27N7O3/c1-15-21(25-17-4-2-3-5-18(17)27-6-10-31-11-7-27)29-22(24-15)16(20(23)30)14-19(26-29)28-8-12-32-13-9-28/h2-5,14,25H,6-13H2,1H3,(H2,23,30)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	3.63E+3	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description Kinase enzyme binding affinities of compounds disclosed herein were determined using the KINOMEscan technology performed by DiscoveRx Corporation, Sa...				US Patent US10087187 (2018) BindingDB Entry DOI: 10.7270/Q2M61N9J
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase mTOR (Homo sapiens (Human))	BDBM288392 (US10087187, Compound 87) Show SMILES Cc1nc2c(cc(nn2c1Nc1ccccc1N1CCOCC1)N1CCOCC1)C(N)=O Show InChI InChI=1S/C22H27N7O3/c1-15-21(25-17-4-2-3-5-18(17)27-6-10-31-11-7-27)29-22(24-15)16(20(23)30)14-19(26-29)28-8-12-32-13-9-28/h2-5,14,25H,6-13H2,1H3,(H2,23,30)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	5.89E+3	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description Kinase enzyme binding affinities of compounds disclosed herein were determined using the KINOMEscan technology performed by DiscoveRx Corporation, Sa...				US Patent US10087187 (2018) BindingDB Entry DOI: 10.7270/Q2M61N9J
					More data for this Ligand-Target Pair
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta (Homo sapiens (Human))	BDBM288393 (US10087187, Compound 88) Show SMILES Cc1nc2c(N)cc(nn2c1Nc1ccccc1N1CCOCC1)N1CCOCC1 Show InChI InChI=1S/C21H27N7O2/c1-15-20(24-17-4-2-3-5-18(17)26-6-10-29-11-7-26)28-21(23-15)16(22)14-19(25-28)27-8-12-30-13-9-27/h2-5,14,24H,6-13,22H2,1H3	NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	12	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description Kinase enzyme binding affinities of compounds disclosed herein were determined using the KINOMEscan technology performed by DiscoveRx Corporation, Sa...				US Patent US10087187 (2018) BindingDB Entry DOI: 10.7270/Q2M61N9J
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Homo sapiens (Human))	BDBM288393 (US10087187, Compound 88) Show SMILES Cc1nc2c(N)cc(nn2c1Nc1ccccc1N1CCOCC1)N1CCOCC1 Show InChI InChI=1S/C21H27N7O2/c1-15-20(24-17-4-2-3-5-18(17)26-6-10-29-11-7-26)28-21(23-15)16(22)14-19(25-28)27-8-12-30-13-9-27/h2-5,14,24H,6-13,22H2,1H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	69	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description Kinase enzyme binding affinities of compounds disclosed herein were determined using the KINOMEscan technology performed by DiscoveRx Corporation, Sa...				US Patent US10087187 (2018) BindingDB Entry DOI: 10.7270/Q2M61N9J
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (Homo sapiens (Human))	BDBM288393 (US10087187, Compound 88) Show SMILES Cc1nc2c(N)cc(nn2c1Nc1ccccc1N1CCOCC1)N1CCOCC1 Show InChI InChI=1S/C21H27N7O2/c1-15-20(24-17-4-2-3-5-18(17)26-6-10-29-11-7-26)28-21(23-15)16(22)14-19(25-28)27-8-12-30-13-9-27/h2-5,14,24H,6-13,22H2,1H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	8.32E+3	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description Kinase enzyme binding affinities of compounds disclosed herein were determined using the KINOMEscan technology performed by DiscoveRx Corporation, Sa...				US Patent US10087187 (2018) BindingDB Entry DOI: 10.7270/Q2M61N9J
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase mTOR (Homo sapiens (Human))	BDBM288393 (US10087187, Compound 88) Show SMILES Cc1nc2c(N)cc(nn2c1Nc1ccccc1N1CCOCC1)N1CCOCC1 Show InChI InChI=1S/C21H27N7O2/c1-15-20(24-17-4-2-3-5-18(17)26-6-10-29-11-7-26)28-21(23-15)16(22)14-19(25-28)27-8-12-30-13-9-27/h2-5,14,24H,6-13,22H2,1H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	8.71E+3	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description Kinase enzyme binding affinities of compounds disclosed herein were determined using the KINOMEscan technology performed by DiscoveRx Corporation, Sa...				US Patent US10087187 (2018) BindingDB Entry DOI: 10.7270/Q2M61N9J
					More data for this Ligand-Target Pair
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha (Homo sapiens (Human))	BDBM288394 (US10087187, Compound 89) Show SMILES Cc1nc2c(cc(nn2c1Nc1ccccc1N1CCOCC1)N1CCOCC1)-c1ccn[nH]1 Show InChI InChI=1S/C24H28N8O2/c1-17-23(27-20-4-2-3-5-21(20)30-8-12-33-13-9-30)32-24(26-17)18(19-6-7-25-28-19)16-22(29-32)31-10-14-34-15-11-31/h2-7,16,27H,8-15H2,1H3,(H,25,28)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	631	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description Kinase enzyme binding affinities of compounds disclosed herein were determined using the KINOMEscan technology performed by DiscoveRx Corporation, Sa...				US Patent US10087187 (2018) BindingDB Entry DOI: 10.7270/Q2M61N9J
					More data for this Ligand-Target Pair
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta (Homo sapiens (Human))	BDBM288394 (US10087187, Compound 89) Show SMILES Cc1nc2c(cc(nn2c1Nc1ccccc1N1CCOCC1)N1CCOCC1)-c1ccn[nH]1 Show InChI InChI=1S/C24H28N8O2/c1-17-23(27-20-4-2-3-5-21(20)30-8-12-33-13-9-30)32-24(26-17)18(19-6-7-25-28-19)16-22(29-32)31-10-14-34-15-11-31/h2-7,16,27H,8-15H2,1H3,(H,25,28)	NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	22	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description Kinase enzyme binding affinities of compounds disclosed herein were determined using the KINOMEscan technology performed by DiscoveRx Corporation, Sa...				US Patent US10087187 (2018) BindingDB Entry DOI: 10.7270/Q2M61N9J
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Homo sapiens (Human))	BDBM288394 (US10087187, Compound 89) Show SMILES Cc1nc2c(cc(nn2c1Nc1ccccc1N1CCOCC1)N1CCOCC1)-c1ccn[nH]1 Show InChI InChI=1S/C24H28N8O2/c1-17-23(27-20-4-2-3-5-21(20)30-8-12-33-13-9-30)32-24(26-17)18(19-6-7-25-28-19)16-22(29-32)31-10-14-34-15-11-31/h2-7,16,27H,8-15H2,1H3,(H,25,28)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	44	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description Kinase enzyme binding affinities of compounds disclosed herein were determined using the KINOMEscan technology performed by DiscoveRx Corporation, Sa...				US Patent US10087187 (2018) BindingDB Entry DOI: 10.7270/Q2M61N9J
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (Homo sapiens (Human))	BDBM288394 (US10087187, Compound 89) Show SMILES Cc1nc2c(cc(nn2c1Nc1ccccc1N1CCOCC1)N1CCOCC1)-c1ccn[nH]1 Show InChI InChI=1S/C24H28N8O2/c1-17-23(27-20-4-2-3-5-21(20)30-8-12-33-13-9-30)32-24(26-17)18(19-6-7-25-28-19)16-22(29-32)31-10-14-34-15-11-31/h2-7,16,27H,8-15H2,1H3,(H,25,28)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	851	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description Kinase enzyme binding affinities of compounds disclosed herein were determined using the KINOMEscan technology performed by DiscoveRx Corporation, Sa...				US Patent US10087187 (2018) BindingDB Entry DOI: 10.7270/Q2M61N9J
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase mTOR (Homo sapiens (Human))	BDBM288394 (US10087187, Compound 89) Show SMILES Cc1nc2c(cc(nn2c1Nc1ccccc1N1CCOCC1)N1CCOCC1)-c1ccn[nH]1 Show InChI InChI=1S/C24H28N8O2/c1-17-23(27-20-4-2-3-5-21(20)30-8-12-33-13-9-30)32-24(26-17)18(19-6-7-25-28-19)16-22(29-32)31-10-14-34-15-11-31/h2-7,16,27H,8-15H2,1H3,(H,25,28)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	85	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description Kinase enzyme binding affinities of compounds disclosed herein were determined using the KINOMEscan technology performed by DiscoveRx Corporation, Sa...				US Patent US10087187 (2018) BindingDB Entry DOI: 10.7270/Q2M61N9J
					More data for this Ligand-Target Pair
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha (Homo sapiens (Human))	BDBM288395 (US10087187, Compound 91) Show SMILES Cc1c(Cc2c(nc3c(N)cc(nn23)N2CCOCC2)C(O)CN)cccc1C(F)(F)F Show InChI InChI=1S/C21H25F3N6O2/c1-12-13(3-2-4-14(12)21(22,23)24)9-16-19(17(31)11-25)27-20-15(26)10-18(28-30(16)20)29-5-7-32-8-6-29/h2-4,10,17,31H,5-9,11,25-26H2,1H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	8.91E+3	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description Kinase enzyme binding affinities of compounds disclosed herein were determined using the KINOMEscan technology performed by DiscoveRx Corporation, Sa...				US Patent US10087187 (2018) BindingDB Entry DOI: 10.7270/Q2M61N9J
					More data for this Ligand-Target Pair
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta (Homo sapiens (Human))	BDBM288395 (US10087187, Compound 91) Show SMILES Cc1c(Cc2c(nc3c(N)cc(nn23)N2CCOCC2)C(O)CN)cccc1C(F)(F)F Show InChI InChI=1S/C21H25F3N6O2/c1-12-13(3-2-4-14(12)21(22,23)24)9-16-19(17(31)11-25)27-20-15(26)10-18(28-30(16)20)29-5-7-32-8-6-29/h2-4,10,17,31H,5-9,11,25-26H2,1H3	NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	1.10	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description Kinase enzyme binding affinities of compounds disclosed herein were determined using the KINOMEscan technology performed by DiscoveRx Corporation, Sa...				US Patent US10087187 (2018) BindingDB Entry DOI: 10.7270/Q2M61N9J
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (Homo sapiens (Human))	BDBM288395 (US10087187, Compound 91) Show SMILES Cc1c(Cc2c(nc3c(N)cc(nn23)N2CCOCC2)C(O)CN)cccc1C(F)(F)F Show InChI InChI=1S/C21H25F3N6O2/c1-12-13(3-2-4-14(12)21(22,23)24)9-16-19(17(31)11-25)27-20-15(26)10-18(28-30(16)20)29-5-7-32-8-6-29/h2-4,10,17,31H,5-9,11,25-26H2,1H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	8.13E+3	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description Kinase enzyme binding affinities of compounds disclosed herein were determined using the KINOMEscan technology performed by DiscoveRx Corporation, Sa...				US Patent US10087187 (2018) BindingDB Entry DOI: 10.7270/Q2M61N9J
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase mTOR (Homo sapiens (Human))	BDBM288395 (US10087187, Compound 91) Show SMILES Cc1c(Cc2c(nc3c(N)cc(nn23)N2CCOCC2)C(O)CN)cccc1C(F)(F)F Show InChI InChI=1S/C21H25F3N6O2/c1-12-13(3-2-4-14(12)21(22,23)24)9-16-19(17(31)11-25)27-20-15(26)10-18(28-30(16)20)29-5-7-32-8-6-29/h2-4,10,17,31H,5-9,11,25-26H2,1H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	776	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description Kinase enzyme binding affinities of compounds disclosed herein were determined using the KINOMEscan technology performed by DiscoveRx Corporation, Sa...				US Patent US10087187 (2018) BindingDB Entry DOI: 10.7270/Q2M61N9J
					More data for this Ligand-Target Pair
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha (Homo sapiens (Human))	BDBM288396 (US10087187, Compound 93) Show SMILES Cc1c(F)cccc1Cc1c(CO)nc2c(N)cc(nn12)N1CCOCC1 Show InChI InChI=1S/C19H22FN5O2/c1-12-13(3-2-4-14(12)20)9-17-16(11-26)22-19-15(21)10-18(23-25(17)19)24-5-7-27-8-6-24/h2-4,10,26H,5-9,11,21H2,1H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	>3.02E+4	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description Kinase enzyme binding affinities of compounds disclosed herein were determined using the KINOMEscan technology performed by DiscoveRx Corporation, Sa...				US Patent US10087187 (2018) BindingDB Entry DOI: 10.7270/Q2M61N9J
					More data for this Ligand-Target Pair
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta (Homo sapiens (Human))	BDBM288396 (US10087187, Compound 93) Show SMILES Cc1c(F)cccc1Cc1c(CO)nc2c(N)cc(nn12)N1CCOCC1 Show InChI InChI=1S/C19H22FN5O2/c1-12-13(3-2-4-14(12)20)9-17-16(11-26)22-19-15(21)10-18(23-25(17)19)24-5-7-27-8-6-24/h2-4,10,26H,5-9,11,21H2,1H3	NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	2.70	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description Kinase enzyme binding affinities of compounds disclosed herein were determined using the KINOMEscan technology performed by DiscoveRx Corporation, Sa...				US Patent US10087187 (2018) BindingDB Entry DOI: 10.7270/Q2M61N9J
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Homo sapiens (Human))	BDBM288396 (US10087187, Compound 93) Show SMILES Cc1c(F)cccc1Cc1c(CO)nc2c(N)cc(nn12)N1CCOCC1 Show InChI InChI=1S/C19H22FN5O2/c1-12-13(3-2-4-14(12)20)9-17-16(11-26)22-19-15(21)10-18(23-25(17)19)24-5-7-27-8-6-24/h2-4,10,26H,5-9,11,21H2,1H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	166	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description Kinase enzyme binding affinities of compounds disclosed herein were determined using the KINOMEscan technology performed by DiscoveRx Corporation, Sa...				US Patent US10087187 (2018) BindingDB Entry DOI: 10.7270/Q2M61N9J
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (Homo sapiens (Human))	BDBM288396 (US10087187, Compound 93) Show SMILES Cc1c(F)cccc1Cc1c(CO)nc2c(N)cc(nn12)N1CCOCC1 Show InChI InChI=1S/C19H22FN5O2/c1-12-13(3-2-4-14(12)20)9-17-16(11-26)22-19-15(21)10-18(23-25(17)19)24-5-7-27-8-6-24/h2-4,10,26H,5-9,11,21H2,1H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	3.89E+3	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description Kinase enzyme binding affinities of compounds disclosed herein were determined using the KINOMEscan technology performed by DiscoveRx Corporation, Sa...				US Patent US10087187 (2018) BindingDB Entry DOI: 10.7270/Q2M61N9J
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase mTOR (Homo sapiens (Human))	BDBM288396 (US10087187, Compound 93) Show SMILES Cc1c(F)cccc1Cc1c(CO)nc2c(N)cc(nn12)N1CCOCC1 Show InChI InChI=1S/C19H22FN5O2/c1-12-13(3-2-4-14(12)20)9-17-16(11-26)22-19-15(21)10-18(23-25(17)19)24-5-7-27-8-6-24/h2-4,10,26H,5-9,11,21H2,1H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	1.91E+3	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description Kinase enzyme binding affinities of compounds disclosed herein were determined using the KINOMEscan technology performed by DiscoveRx Corporation, Sa...				US Patent US10087187 (2018) BindingDB Entry DOI: 10.7270/Q2M61N9J
					More data for this Ligand-Target Pair

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