Found 12 hits with Last Name = 'fan' and Initial = 'hj' Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
5-hydroxytryptamine receptor 2A
(BOVINE) | BDBM50005836
(4-Amino-5-chloro-N-{1-[3-(4-fluoro-phenoxy)-propyl...)Show SMILES COC1CN(CCCOc2ccc(F)cc2)CCC1NC(=O)c1cc(Cl)c(N)cc1OC Show InChI InChI=1S/C23H29ClFN3O4/c1-30-21-13-19(26)18(24)12-17(21)23(29)27-20-8-10-28(14-22(20)31-2)9-3-11-32-16-6-4-15(25)5-7-16/h4-7,12-13,20,22H,3,8-11,14,26H2,1-2H3,(H,27,29) | PDB
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| 7.20 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Sandoz Pharma Limited
Curated by ChEMBL
| Assay Description
Compound was evaluated for the binding affinity at 5- HT2 receptor |
J Med Chem 38: 2326-30 (1995)
BindingDB Entry DOI: 10.7270/Q2W959VM |
More data for this
Ligand-Target Pair | |
Alpha-2A adrenergic receptor [16-465]
(Rattus norvegicus (rat)) | BDBM50005836
(4-Amino-5-chloro-N-{1-[3-(4-fluoro-phenoxy)-propyl...)Show SMILES COC1CN(CCCOc2ccc(F)cc2)CCC1NC(=O)c1cc(Cl)c(N)cc1OC Show InChI InChI=1S/C23H29ClFN3O4/c1-30-21-13-19(26)18(24)12-17(21)23(29)27-20-8-10-28(14-22(20)31-2)9-3-11-32-16-6-4-15(25)5-7-16/h4-7,12-13,20,22H,3,8-11,14,26H2,1-2H3,(H,27,29) | PDB
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| 30 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Sandoz Pharma Limited
Curated by ChEMBL
| Assay Description
Compound was evaluated for the binding affinity at Alpha adrenergic receptor |
J Med Chem 38: 2326-30 (1995)
BindingDB Entry DOI: 10.7270/Q2W959VM |
More data for this
Ligand-Target Pair | |
5-hydroxytryptamine receptor 1A
(Homo sapiens (Human)) | BDBM50031474
((2E)-2-[(5-hydroxy-1H-indol-3-yl)methylene]hydrazi...)Show InChI InChI=1S/C10H11N5O/c11-10(12)15-14-5-6-4-13-9-2-1-7(16)3-8(6)9/h1-5,13,16H,(H4,11,12,15) | PDB
UniProtKB/SwissProt
antibodypedia
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| CHEMBL
PC cid
PC sid
UniChem
| PubMed
| 63 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Sandoz Pharma Limited
Curated by ChEMBL
| Assay Description
Compound was evaluated for the binding affinity at 5- HT1A receptor |
J Med Chem 38: 2326-30 (1995)
BindingDB Entry DOI: 10.7270/Q2W959VM |
More data for this
Ligand-Target Pair | |
D(2) dopamine receptor
(BOVINE) | BDBM48320
(4-amino-5-chloro-N-[2-(diethylamino)ethyl]-2-metho...)Show InChI InChI=1S/C14H22ClN3O2/c1-4-18(5-2)7-6-17-14(19)10-8-11(15)12(16)9-13(10)20-3/h8-9H,4-7,16H2,1-3H3,(H,17,19) | PDB
UniProtKB/SwissProt
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| 80 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Sandoz Pharma Limited
Curated by ChEMBL
| Assay Description
Compound was evaluated for the binding affinity at Dopamine receptor D2 |
J Med Chem 38: 2326-30 (1995)
BindingDB Entry DOI: 10.7270/Q2W959VM |
More data for this
Ligand-Target Pair | |
5-hydroxytryptamine 1D receptor
(Bos taurus (Bovine)) | BDBM50056401
(2-diethylaminoethyl [2-methoxy-4-amino-5-chloro]be...)Show InChI InChI=1S/C14H21ClN2O3/c1-4-17(5-2)6-7-20-14(18)10-8-11(15)12(16)9-13(10)19-3/h8-9H,4-7,16H2,1-3H3 | PDB
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| Article
PubMed
| 2.51E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
SANDOZ Pharma Ltd.
Curated by PDSP Ki Database
| |
Naunyn Schmiedebergs Arch Pharmacol 345: 387-93 (1992)
Article DOI: 10.1007/bf00176615
BindingDB Entry DOI: 10.7270/Q2M043WM |
More data for this
Ligand-Target Pair | |
5-hydroxytryptamine receptor 2C
(PIG) | BDBM50056401
(2-diethylaminoethyl [2-methoxy-4-amino-5-chloro]be...)Show InChI InChI=1S/C14H21ClN2O3/c1-4-17(5-2)6-7-20-14(18)10-8-11(15)12(16)9-13(10)19-3/h8-9H,4-7,16H2,1-3H3 | PDB
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| Article
PubMed
| 3.98E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
SANDOZ Pharma Ltd.
Curated by PDSP Ki Database
| |
Naunyn Schmiedebergs Arch Pharmacol 345: 387-93 (1992)
Article DOI: 10.1007/bf00176615
BindingDB Entry DOI: 10.7270/Q2M043WM |
More data for this
Ligand-Target Pair | |
Alpha-1A adrenergic receptor
(CALF) | BDBM50056401
(2-diethylaminoethyl [2-methoxy-4-amino-5-chloro]be...)Show InChI InChI=1S/C14H21ClN2O3/c1-4-17(5-2)6-7-20-14(18)10-8-11(15)12(16)9-13(10)19-3/h8-9H,4-7,16H2,1-3H3 | PDB
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| 6.31E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
SANDOZ Pharma Ltd.
Curated by PDSP Ki Database
| |
Naunyn Schmiedebergs Arch Pharmacol 345: 387-93 (1992)
Article DOI: 10.1007/bf00176615
BindingDB Entry DOI: 10.7270/Q2M043WM |
More data for this
Ligand-Target Pair | |
Alpha-2A adrenergic receptor
(BOVINE) | BDBM50056401
(2-diethylaminoethyl [2-methoxy-4-amino-5-chloro]be...)Show InChI InChI=1S/C14H21ClN2O3/c1-4-17(5-2)6-7-20-14(18)10-8-11(15)12(16)9-13(10)19-3/h8-9H,4-7,16H2,1-3H3 | PDB
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| >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
SANDOZ Pharma Ltd.
Curated by PDSP Ki Database
| |
Naunyn Schmiedebergs Arch Pharmacol 345: 387-93 (1992)
Article DOI: 10.1007/bf00176615
BindingDB Entry DOI: 10.7270/Q2M043WM |
More data for this
Ligand-Target Pair | |
5-hydroxytryptamine receptor 2A
(Rattus norvegicus (rat)) | BDBM50056401
(2-diethylaminoethyl [2-methoxy-4-amino-5-chloro]be...)Show InChI InChI=1S/C14H21ClN2O3/c1-4-17(5-2)6-7-20-14(18)10-8-11(15)12(16)9-13(10)19-3/h8-9H,4-7,16H2,1-3H3 | PDB
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PC sid
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PubMed
| >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
SANDOZ Pharma Ltd.
Curated by PDSP Ki Database
| |
Naunyn Schmiedebergs Arch Pharmacol 345: 387-93 (1992)
Article DOI: 10.1007/bf00176615
BindingDB Entry DOI: 10.7270/Q2M043WM |
More data for this
Ligand-Target Pair | |
Mu-type opioid receptor
(Rattus norvegicus (rat)) | BDBM50056401
(2-diethylaminoethyl [2-methoxy-4-amino-5-chloro]be...)Show InChI InChI=1S/C14H21ClN2O3/c1-4-17(5-2)6-7-20-14(18)10-8-11(15)12(16)9-13(10)19-3/h8-9H,4-7,16H2,1-3H3 | PDB
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| >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
SANDOZ Pharma Ltd.
Curated by PDSP Ki Database
| |
Naunyn Schmiedebergs Arch Pharmacol 345: 387-93 (1992)
Article DOI: 10.1007/bf00176615
BindingDB Entry DOI: 10.7270/Q2M043WM |
More data for this
Ligand-Target Pair | |
Fatty acid synthase
(Gallus gallus (Chicken)) | BDBM50349517
(CHEMBL1808693)Show SMILES [O-][N+](=O)c1cccc(c1)-c1csc(N=NCc2ccccn2)n1 |w:14.15| Show InChI InChI=1S/C15H11N5O2S/c21-20(22)13-6-3-4-11(8-13)14-10-23-15(18-14)19-17-9-12-5-1-2-7-16-12/h1-8,10H,9H2 | UniProtKB/SwissProt
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| n/a | n/a | 1.27E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Sichuan University
Curated by ChEMBL
| Assay Description
Inhibition of chicken FAS by spectrophotometric analysis |
Bioorg Med Chem Lett 21: 4742-4 (2011)
Article DOI: 10.1016/j.bmcl.2011.06.075
BindingDB Entry DOI: 10.7270/Q2RV0P27 |
More data for this
Ligand-Target Pair | |
Aldehyde dehydrogenase, mitochondrial
(Homo sapiens (Human)) | BDBM78304
(2-(2-hydroxy-5-prop-2-enylphenyl)-4-prop-2-enylphe...)Show InChI InChI=1S/C18H18O2/c1-3-5-13-7-9-17(19)15(11-13)16-12-14(6-4-2)8-10-18(16)20/h3-4,7-12,19-20H,1-2,5-6H2 | PDB
MMDB
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| n/a | n/a | n/a | n/a | 5.79E+4 | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Agonist activity at human recombinant ALDH2 measured after 1 hr |
Citation and Details
Article DOI: 10.1016/j.bmcl.2021.128045
BindingDB Entry DOI: 10.7270/Q2N301QC |
More data for this
Ligand-Target Pair | |
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