Found 122 hits with Last Name = 'grandi' and Initial = 'n' Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Integrase
(Human immunodeficiency virus 1) | BDBM25351
(N-[2-(4-{[(4-fluorophenyl)methyl]carbamoyl}-5-hydr...)Show SMILES Cc1nnc(o1)C(=O)NC(C)(C)c1nc(C(=O)NCc2ccc(F)cc2)c(O)c(=O)n1C Show InChI InChI=1S/C20H21FN6O5/c1-10-25-26-17(32-10)16(30)24-20(2,3)19-23-13(14(28)18(31)27(19)4)15(29)22-9-11-5-7-12(21)8-6-11/h5-8,28H,9H2,1-4H3,(H,22,29)(H,24,30) | PDB
MMDB
UniProtKB/TrEMBL
B.MOAD
DrugBank
GoogleScholar
AffyNet 
| Purchase
DrugBank
MCE
MMDB
PC cid
PC sid
PDB
UniChem
Similars
| DrugBank
Article
PubMed
| n/a | n/a | 19 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.1c00535
BindingDB Entry DOI: 10.7270/Q2V98D1X |
More data for this
Ligand-Target Pair | |
Gag-Pol polyprotein
(Human immunodeficiency virus type 1 group M subtyp...) | BDBM2483
((4S)-6-chloro-4-(2-cyclopropylethynyl)-4-(trifluor...)Show SMILES FC(F)(F)[C@]1(OC(=O)Nc2ccc(Cl)cc12)C#CC1CC1 |r| Show InChI InChI=1S/C14H9ClF3NO2/c15-9-3-4-11-10(7-9)13(14(16,17)18,21-12(20)19-11)6-5-8-1-2-8/h3-4,7-8H,1-2H2,(H,19,20)/t13-/m0/s1 | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| Purchase
CHEMBL
DrugBank
MCE
KEGG
MMDB
PC cid
PC sid
PDB
UniChem
Patents
Similars
| MMDB
PDB
Article
PubMed
| n/a | n/a | 20 | n/a | n/a | n/a | n/a | 8.1 | 37 |
University of Siena
| Assay Description
RNA-dependent DNA polymerase (RDDP) activity was measured as described[J. Microbiol. 2015, 53:288-293] in Tris·HCl buffer (25 mL, 60 mm, pH 8.1) con... |
Chembiochem 17: 683-8 (2016)
Article DOI: 10.1002/cbic.201500668
BindingDB Entry DOI: 10.7270/Q25H7F28 |
More data for this
Ligand-Target Pair | 
3D Structure (crystal) |
Reverse transcriptase/RNaseH
(Human immunodeficiency virus 1) | BDBM2483
((4S)-6-chloro-4-(2-cyclopropylethynyl)-4-(trifluor...)Show SMILES FC(F)(F)[C@]1(OC(=O)Nc2ccc(Cl)cc12)C#CC1CC1 |r| Show InChI InChI=1S/C14H9ClF3NO2/c15-9-3-4-11-10(7-9)13(14(16,17)18,21-12(20)19-11)6-5-8-1-2-8/h3-4,7-8H,1-2H2,(H,19,20)/t13-/m0/s1 | PDB
MMDB
UniProtKB/TrEMBL
B.MOAD
DrugBank
GoogleScholar
AffyNet
| Purchase
CHEMBL
DrugBank
MCE
KEGG
MMDB
PC cid
PC sid
PDB
UniChem
Patents
Similars
| DrugBank
MMDB
PDB
Article
PubMed
| n/a | n/a | 35 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.1c00535
BindingDB Entry DOI: 10.7270/Q2V98D1X |
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
Integrase
(Human immunodeficiency virus 1) | BDBM50587990
(CHEMBL5182942)Show SMILES CCOC(=O)c1cn(Cc2ccc(F)cc2)c2ccc(OCc3cccc(Cl)c3Cl)cc2c1=O | PDB
MMDB
UniProtKB/TrEMBL
B.MOAD
DrugBank
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 50 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.1c00535
BindingDB Entry DOI: 10.7270/Q2V98D1X |
More data for this
Ligand-Target Pair | |
Reverse transcriptase/RNaseH
(Human immunodeficiency virus 1) | BDBM33411
(β-Thujaplicinol | hydroxytropolone, 3)Show InChI InChI=1S/C10H12O3/c1-6(2)7-3-4-8(11)10(13)9(12)5-7/h3-6H,1-2H3,(H2,11,12,13) | PDB
MMDB
UniProtKB/TrEMBL
B.MOAD
DrugBank
GoogleScholar
AffyNet
| MMDB
PC cid
PC sid
PDB
UniChem
Patents
Similars
| MMDB
PDB
Article
PubMed
| n/a | n/a | 190 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.1c00535
BindingDB Entry DOI: 10.7270/Q2V98D1X |
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
Reverse transcriptase/RNaseH
(Human immunodeficiency virus 1) | BDBM50540702
(CHEMBL4641618)Show SMILES OC(=O)c1cc(n[nH]1)-c1cn(Cc2ccc(F)cc2)cc1-c1ccc(OCCCCc2ccccc2)cc1 Show InChI InChI=1S/C31H28FN3O3/c32-25-13-9-23(10-14-25)19-35-20-27(28(21-35)29-18-30(31(36)37)34-33-29)24-11-15-26(16-12-24)38-17-5-4-8-22-6-2-1-3-7-22/h1-3,6-7,9-16,18,20-21H,4-5,8,17,19H2,(H,33,34)(H,36,37) | PDB
MMDB
UniProtKB/TrEMBL
B.MOAD
DrugBank
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 270 | n/a | n/a | n/a | n/a | n/a | n/a |
"Sapienza" Universit£ di Roma
Curated by ChEMBL
| Assay Description
Inhibition of RNase H activity of recombinant His-tagged HIV-1 group M subtype B reverse transcriptase p66/p51 expressed in Escherichia coli M15 usin... |
ACS Med Chem Lett 11: 798-805 (2020)
Article DOI: 10.1021/acsmedchemlett.9b00617
BindingDB Entry DOI: 10.7270/Q2T1576W |
More data for this
Ligand-Target Pair | |
Integrase
(Human immunodeficiency virus 1) | BDBM50587966
(CHEMBL5188823)Show SMILES OC(=O)c1cn(Cc2ccc(F)cc2)c2ccc(OCc3ccccc3)cc2c1=O | PDB
MMDB
UniProtKB/TrEMBL
B.MOAD
DrugBank
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 410 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.1c00535
BindingDB Entry DOI: 10.7270/Q2V98D1X |
More data for this
Ligand-Target Pair | |
Reverse transcriptase/RNaseH
(Human immunodeficiency virus 1) | BDBM50587988
(CHEMBL5172754)Show SMILES CCOC(=O)c1cn(Cc2ccc(F)cc2)c2ccc(OCc3cccc4ccccc34)cc2c1=O | PDB
MMDB
UniProtKB/TrEMBL
B.MOAD
DrugBank
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 1.49E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.1c00535
BindingDB Entry DOI: 10.7270/Q2V98D1X |
More data for this
Ligand-Target Pair | |
Reverse transcriptase/RNaseH
(Human immunodeficiency virus 1) | BDBM50587969
(CHEMBL5173288)Show SMILES OC(=O)c1cn(Cc2ccc(F)cc2)c2ccc(OCc3cccc4ccccc34)cc2c1=O | PDB
MMDB
UniProtKB/TrEMBL
B.MOAD
DrugBank
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 1.51E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.1c00535
BindingDB Entry DOI: 10.7270/Q2V98D1X |
More data for this
Ligand-Target Pair | |
Reverse transcriptase/RNaseH
(Human immunodeficiency virus 1) | BDBM50540705
(CHEMBL4641010)Show SMILES OC(=O)c1cc(n[nH]1)-c1cn(Cc2cccc3ccccc23)cc1-c1ccc(OCc2cccc3ccccc23)cc1 Show InChI InChI=1S/C36H27N3O3/c40-36(41)35-19-34(37-38-35)33-22-39(20-27-11-5-9-24-7-1-3-13-30(24)27)21-32(33)26-15-17-29(18-16-26)42-23-28-12-6-10-25-8-2-4-14-31(25)28/h1-19,21-22H,20,23H2,(H,37,38)(H,40,41) | PDB
MMDB
UniProtKB/TrEMBL
B.MOAD
DrugBank
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 1.73E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
"Sapienza" Universit£ di Roma
Curated by ChEMBL
| Assay Description
Inhibition of RNase H activity of recombinant His-tagged HIV-1 group M subtype B reverse transcriptase p66/p51 expressed in Escherichia coli M15 usin... |
ACS Med Chem Lett 11: 798-805 (2020)
Article DOI: 10.1021/acsmedchemlett.9b00617
BindingDB Entry DOI: 10.7270/Q2T1576W |
More data for this
Ligand-Target Pair | |
Reverse transcriptase/RNaseH
(Human immunodeficiency virus 1) | BDBM50587990
(CHEMBL5182942)Show SMILES CCOC(=O)c1cn(Cc2ccc(F)cc2)c2ccc(OCc3cccc(Cl)c3Cl)cc2c1=O | PDB
MMDB
UniProtKB/TrEMBL
B.MOAD
DrugBank
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 1.88E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.1c00535
BindingDB Entry DOI: 10.7270/Q2V98D1X |
More data for this
Ligand-Target Pair | |
Reverse transcriptase/RNaseH
(Human immunodeficiency virus 1) | BDBM50587968
(CHEMBL5198940)Show SMILES OC(=O)c1cn(Cc2ccc(F)cc2)c2ccc(OCc3ccc(Cl)c(Cl)c3)cc2c1=O | PDB
MMDB
UniProtKB/TrEMBL
B.MOAD
DrugBank
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 2.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.1c00535
BindingDB Entry DOI: 10.7270/Q2V98D1X |
More data for this
Ligand-Target Pair | |
Reverse transcriptase/RNaseH
(Human immunodeficiency virus 1) | BDBM50587974
(CHEMBL5185855)Show SMILES OC(=O)c1cn(Cc2ccc(F)cc2)c2ccc(OCc3ccc(Oc4ccccc4)cc3)cc2c1=O | PDB
MMDB
UniProtKB/TrEMBL
B.MOAD
DrugBank
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 2.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.1c00535
BindingDB Entry DOI: 10.7270/Q2V98D1X |
More data for this
Ligand-Target Pair | |
Reverse transcriptase/RNaseH
(Human immunodeficiency virus 1) | BDBM50540703
(CHEMBL4639414)Show SMILES OC(=O)c1cc(n[nH]1)-c1cn(Cc2cccc3ccccc23)cc1-c1ccc(OCCCCc2ccccc2)cc1 Show InChI InChI=1S/C35H31N3O3/c39-35(40)34-21-33(36-37-34)32-24-38(22-28-14-8-13-26-12-4-5-15-30(26)28)23-31(32)27-16-18-29(19-17-27)41-20-7-6-11-25-9-2-1-3-10-25/h1-5,8-10,12-19,21,23-24H,6-7,11,20,22H2,(H,36,37)(H,39,40) | PDB
MMDB
UniProtKB/TrEMBL
B.MOAD
DrugBank
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 2.38E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
"Sapienza" Universit£ di Roma
Curated by ChEMBL
| Assay Description
Inhibition of RNase H activity of recombinant His-tagged HIV-1 group M subtype B reverse transcriptase p66/p51 expressed in Escherichia coli M15 usin... |
ACS Med Chem Lett 11: 798-805 (2020)
Article DOI: 10.1021/acsmedchemlett.9b00617
BindingDB Entry DOI: 10.7270/Q2T1576W |
More data for this
Ligand-Target Pair | |
Reverse transcriptase/RNaseH
(Human immunodeficiency virus 1) | BDBM50540701
(CHEMBL4648383)Show SMILES OC(=O)c1cc(n[nH]1)-c1cn(Cc2ccc(F)cc2)cc1-c1ccc(OCc2ccccc2)cc1 Show InChI InChI=1S/C28H22FN3O3/c29-22-10-6-19(7-11-22)15-32-16-24(25(17-32)26-14-27(28(33)34)31-30-26)21-8-12-23(13-9-21)35-18-20-4-2-1-3-5-20/h1-14,16-17H,15,18H2,(H,30,31)(H,33,34) | PDB
MMDB
UniProtKB/TrEMBL
B.MOAD
DrugBank
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 3.21E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
"Sapienza" Universit£ di Roma
Curated by ChEMBL
| Assay Description
Inhibition of RNase H activity of recombinant His-tagged HIV-1 group M subtype B reverse transcriptase p66/p51 expressed in Escherichia coli M15 usin... |
ACS Med Chem Lett 11: 798-805 (2020)
Article DOI: 10.1021/acsmedchemlett.9b00617
BindingDB Entry DOI: 10.7270/Q2T1576W |
More data for this
Ligand-Target Pair | |
Integrase
(Human immunodeficiency virus 1) | BDBM50587968
(CHEMBL5198940)Show SMILES OC(=O)c1cn(Cc2ccc(F)cc2)c2ccc(OCc3ccc(Cl)c(Cl)c3)cc2c1=O | PDB
MMDB
UniProtKB/TrEMBL
B.MOAD
DrugBank
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 3.25E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.1c00535
BindingDB Entry DOI: 10.7270/Q2V98D1X |
More data for this
Ligand-Target Pair | |
Integrase
(Human immunodeficiency virus 1) | BDBM50587965
(CHEMBL5176128)Show SMILES OC(=O)c1cn(Cc2ccc(F)cc2)c2ccc(\C=C\C(=O)c3ccccc3)cc2c1=O | PDB
MMDB
UniProtKB/TrEMBL
B.MOAD
DrugBank
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 3.38E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.1c00535
BindingDB Entry DOI: 10.7270/Q2V98D1X |
More data for this
Ligand-Target Pair | |
Reverse transcriptase/RNaseH
(Human immunodeficiency virus 1) | BDBM50540696
(CHEMBL4643229)Show SMILES CCOC(=O)c1cc(n[nH]1)-c1cn(Cc2cccc3ccccc23)cc1-c1ccc(OCc2cccc3ccccc23)cc1 Show InChI InChI=1S/C38H31N3O3/c1-2-43-38(42)37-21-36(39-40-37)35-24-41(22-29-13-7-11-26-9-3-5-15-32(26)29)23-34(35)28-17-19-31(20-18-28)44-25-30-14-8-12-27-10-4-6-16-33(27)30/h3-21,23-24H,2,22,25H2,1H3,(H,39,40) | PDB
MMDB
UniProtKB/TrEMBL
B.MOAD
DrugBank
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 4.15E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
"Sapienza" Universit£ di Roma
Curated by ChEMBL
| Assay Description
Inhibition of RNase H activity of recombinant His-tagged HIV-1 group M subtype B reverse transcriptase p66/p51 expressed in Escherichia coli M15 usin... |
ACS Med Chem Lett 11: 798-805 (2020)
Article DOI: 10.1021/acsmedchemlett.9b00617
BindingDB Entry DOI: 10.7270/Q2T1576W |
More data for this
Ligand-Target Pair | |
Reverse transcriptase/RNaseH
(Human immunodeficiency virus 1) | BDBM50540704
(CHEMBL4634514)Show SMILES OC(=O)c1cc(n[nH]1)-c1cn(Cc2ccc(F)cc2)cc1-c1ccc(OCc2cccc3ccccc23)cc1 Show InChI InChI=1S/C32H24FN3O3/c33-25-12-8-21(9-13-25)17-36-18-28(29(19-36)30-16-31(32(37)38)35-34-30)23-10-14-26(15-11-23)39-20-24-6-3-5-22-4-1-2-7-27(22)24/h1-16,18-19H,17,20H2,(H,34,35)(H,37,38) | PDB
MMDB
UniProtKB/TrEMBL
B.MOAD
DrugBank
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 4.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
"Sapienza" Universit£ di Roma
Curated by ChEMBL
| Assay Description
Inhibition of RNase H activity of recombinant His-tagged HIV-1 group M subtype B reverse transcriptase p66/p51 expressed in Escherichia coli M15 usin... |
ACS Med Chem Lett 11: 798-805 (2020)
Article DOI: 10.1021/acsmedchemlett.9b00617
BindingDB Entry DOI: 10.7270/Q2T1576W |
More data for this
Ligand-Target Pair | |
Reverse transcriptase/RNaseH
(Human immunodeficiency virus 1) | BDBM50587971
(CHEMBL5183730)Show SMILES OC(=O)c1cn(Cc2ccc(F)cc2)c2ccc(OCc3ccc4OCOc4c3)cc2c1=O | PDB
MMDB
UniProtKB/TrEMBL
B.MOAD
DrugBank
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 5.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.1c00535
BindingDB Entry DOI: 10.7270/Q2V98D1X |
More data for this
Ligand-Target Pair | |
Reverse transcriptase/RNaseH
(Human immunodeficiency virus 1) | BDBM50540692
(CHEMBL4649730)Show SMILES CCOC(=O)c1cc(n[nH]1)-c1cn(Cc2ccc(F)cc2)cc1-c1ccc(OCc2ccccc2)cc1 Show InChI InChI=1S/C30H26FN3O3/c1-2-36-30(35)29-16-28(32-33-29)27-19-34(17-21-8-12-24(31)13-9-21)18-26(27)23-10-14-25(15-11-23)37-20-22-6-4-3-5-7-22/h3-16,18-19H,2,17,20H2,1H3,(H,32,33) | PDB
MMDB
UniProtKB/TrEMBL
B.MOAD
DrugBank
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 5.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
"Sapienza" Universit£ di Roma
Curated by ChEMBL
| Assay Description
Inhibition of RNase H activity of recombinant His-tagged HIV-1 group M subtype B reverse transcriptase p66/p51 expressed in Escherichia coli M15 usin... |
ACS Med Chem Lett 11: 798-805 (2020)
Article DOI: 10.1021/acsmedchemlett.9b00617
BindingDB Entry DOI: 10.7270/Q2T1576W |
More data for this
Ligand-Target Pair | |
Reverse transcriptase/RNaseH
(Human immunodeficiency virus 1) | BDBM50540695
(CHEMBL4638007)Show SMILES CCOC(=O)c1cc(n[nH]1)-c1cn(Cc2ccc(F)cc2)cc1-c1ccc(OCc2cccc3ccccc23)cc1 Show InChI InChI=1S/C34H28FN3O3/c1-2-40-34(39)33-18-32(36-37-33)31-21-38(19-23-10-14-27(35)15-11-23)20-30(31)25-12-16-28(17-13-25)41-22-26-8-5-7-24-6-3-4-9-29(24)26/h3-18,20-21H,2,19,22H2,1H3,(H,36,37) | PDB
MMDB
UniProtKB/TrEMBL
B.MOAD
DrugBank
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 5.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
"Sapienza" Universit£ di Roma
Curated by ChEMBL
| Assay Description
Inhibition of RNase H activity of recombinant His-tagged HIV-1 group M subtype B reverse transcriptase p66/p51 expressed in Escherichia coli M15 usin... |
ACS Med Chem Lett 11: 798-805 (2020)
Article DOI: 10.1021/acsmedchemlett.9b00617
BindingDB Entry DOI: 10.7270/Q2T1576W |
More data for this
Ligand-Target Pair | |
Reverse transcriptase/RNaseH
(Human immunodeficiency virus 1) | BDBM50587967
(CHEMBL5197780)Show SMILES OC(=O)c1cn(Cc2ccc(F)cc2)c2ccc(OCc3cccc(Cl)c3Cl)cc2c1=O | PDB
MMDB
UniProtKB/TrEMBL
B.MOAD
DrugBank
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 5.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.1c00535
BindingDB Entry DOI: 10.7270/Q2V98D1X |
More data for this
Ligand-Target Pair | |
Reverse transcriptase/RNaseH
(Human immunodeficiency virus 1) | BDBM50540708
(CHEMBL4640609)Show SMILES OC(=O)c1cc(n[nH]1)-c1cn(Cc2cccc3ccccc23)cc1-c1ccc(OCC(=O)Nc2ccccc2)cc1 Show InChI InChI=1S/C33H26N4O4/c38-32(34-25-10-2-1-3-11-25)21-41-26-15-13-23(14-16-26)28-19-37(20-29(28)30-17-31(33(39)40)36-35-30)18-24-9-6-8-22-7-4-5-12-27(22)24/h1-17,19-20H,18,21H2,(H,34,38)(H,35,36)(H,39,40) | PDB
MMDB
UniProtKB/TrEMBL
B.MOAD
DrugBank
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 5.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
"Sapienza" Universit£ di Roma
Curated by ChEMBL
| Assay Description
Inhibition of RNase H activity of recombinant His-tagged HIV-1 group M subtype B reverse transcriptase p66/p51 expressed in Escherichia coli M15 usin... |
ACS Med Chem Lett 11: 798-805 (2020)
Article DOI: 10.1021/acsmedchemlett.9b00617
BindingDB Entry DOI: 10.7270/Q2T1576W |
More data for this
Ligand-Target Pair | |
Reverse transcriptase/RNaseH
(Human immunodeficiency virus 1) | BDBM50587965
(CHEMBL5176128)Show SMILES OC(=O)c1cn(Cc2ccc(F)cc2)c2ccc(\C=C\C(=O)c3ccccc3)cc2c1=O | PDB
MMDB
UniProtKB/TrEMBL
B.MOAD
DrugBank
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 5.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.1c00535
BindingDB Entry DOI: 10.7270/Q2V98D1X |
More data for this
Ligand-Target Pair | |
Reverse transcriptase/RNaseH
(Human immunodeficiency virus 1) | BDBM50540698
(CHEMBL4644576)Show SMILES CCOC(=O)c1cc(n[nH]1)-c1cn(Cc2ccc(F)cc2)cc1-c1ccc(OCC(=O)Nc2ccccc2)cc1 Show InChI InChI=1S/C31H27FN4O4/c1-2-39-31(38)29-16-28(34-35-29)27-19-36(17-21-8-12-23(32)13-9-21)18-26(27)22-10-14-25(15-11-22)40-20-30(37)33-24-6-4-3-5-7-24/h3-16,18-19H,2,17,20H2,1H3,(H,33,37)(H,34,35) | PDB
MMDB
UniProtKB/TrEMBL
B.MOAD
DrugBank
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 6.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
"Sapienza" Universit£ di Roma
Curated by ChEMBL
| Assay Description
Inhibition of RNase H activity of recombinant His-tagged HIV-1 group M subtype B reverse transcriptase p66/p51 expressed in Escherichia coli M15 usin... |
ACS Med Chem Lett 11: 798-805 (2020)
Article DOI: 10.1021/acsmedchemlett.9b00617
BindingDB Entry DOI: 10.7270/Q2T1576W |
More data for this
Ligand-Target Pair | |
Reverse transcriptase/RNaseH
(Human immunodeficiency virus 1) | BDBM50540710
(CHEMBL4643404)Show SMILES CCOC(=O)C(\O)=C\C(=O)\C=C\c1cccn1Cc1ccccc1Cl Show InChI InChI=1S/C19H18ClNO4/c1-2-25-19(24)18(23)12-16(22)10-9-15-7-5-11-21(15)13-14-6-3-4-8-17(14)20/h3-12,23H,2,13H2,1H3/b10-9+,18-12- | PDB
MMDB
UniProtKB/TrEMBL
B.MOAD
DrugBank
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 7.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
"Sapienza" Universit£ di Roma
Curated by ChEMBL
| Assay Description
Inhibition of RNase H activity of recombinant HIV-1 reverse transcriptase p66/p51 expressed in Escherichia coli M15 using 5'-[gamma32P]ATP-labeled-tC... |
ACS Med Chem Lett 11: 798-805 (2020)
Article DOI: 10.1021/acsmedchemlett.9b00617
BindingDB Entry DOI: 10.7270/Q2T1576W |
More data for this
Ligand-Target Pair | |
Reverse transcriptase/RNaseH
(Human immunodeficiency virus 1) | BDBM50587973
(CHEMBL5198310)Show SMILES OC(=O)c1cn(Cc2ccc(F)cc2)c2ccc(OCc3ccc(cc3)-c3ccccc3)cc2c1=O | PDB
MMDB
UniProtKB/TrEMBL
B.MOAD
DrugBank
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 7.47E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.1c00535
BindingDB Entry DOI: 10.7270/Q2V98D1X |
More data for this
Ligand-Target Pair | |
Reverse transcriptase/RNaseH
(Human immunodeficiency virus 1) | BDBM50587974
(CHEMBL5185855)Show SMILES OC(=O)c1cn(Cc2ccc(F)cc2)c2ccc(OCc3ccc(Oc4ccccc4)cc3)cc2c1=O | PDB
MMDB
UniProtKB/TrEMBL
B.MOAD
DrugBank
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 7.48E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.1c00535
BindingDB Entry DOI: 10.7270/Q2V98D1X |
More data for this
Ligand-Target Pair | |
Gag-Pol polyprotein
(Human immunodeficiency virus type 1 group M subtyp...) | BDBM189342
(RDS1759)Show InChI InChI=1S/C19H18ClNO4/c1-2-25-19(24)18(23)12-16(22)10-9-15-7-5-11-21(15)13-14-6-3-4-8-17(14)20/h3-11H,2,12-13H2,1H3/b10-9+ | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 7.50E+3 | n/a | n/a | n/a | n/a | 7.8 | 37 |
University of Siena
| Assay Description
HIV RT-associated RNase H activity was measured as previously
described.[J. Med. Chem. 2014, 57:3223-3234] Briefly, the reaction
mixture comprised ... |
Chembiochem 17: 683-8 (2016)
Article DOI: 10.1002/cbic.201500668
BindingDB Entry DOI: 10.7270/Q25H7F28 |
More data for this
Ligand-Target Pair | |
Reverse transcriptase/RNaseH
(Human immunodeficiency virus 1) | BDBM50540699
(CHEMBL4648093)Show SMILES CCOC(=O)c1cc(n[nH]1)-c1cn(Cc2cccc3ccccc23)cc1-c1ccc(OCC(=O)Nc2ccccc2)cc1 Show InChI InChI=1S/C35H30N4O4/c1-2-42-35(41)33-19-32(37-38-33)31-22-39(20-26-11-8-10-24-9-6-7-14-29(24)26)21-30(31)25-15-17-28(18-16-25)43-23-34(40)36-27-12-4-3-5-13-27/h3-19,21-22H,2,20,23H2,1H3,(H,36,40)(H,37,38) | PDB
MMDB
UniProtKB/TrEMBL
B.MOAD
DrugBank
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 7.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
"Sapienza" Universit£ di Roma
Curated by ChEMBL
| Assay Description
Inhibition of RNase H activity of recombinant His-tagged HIV-1 group M subtype B reverse transcriptase p66/p51 expressed in Escherichia coli M15 usin... |
ACS Med Chem Lett 11: 798-805 (2020)
Article DOI: 10.1021/acsmedchemlett.9b00617
BindingDB Entry DOI: 10.7270/Q2T1576W |
More data for this
Ligand-Target Pair | |
Reverse transcriptase/RNaseH
(Human immunodeficiency virus 1) | BDBM50587991
(CHEMBL5174596)Show SMILES CCOC(=O)c1cn(Cc2ccc(F)cc2)c2ccc(OCc3ccccc3)cc2c1=O | PDB
MMDB
UniProtKB/TrEMBL
B.MOAD
DrugBank
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 8.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.1c00535
BindingDB Entry DOI: 10.7270/Q2V98D1X |
More data for this
Ligand-Target Pair | |
Reverse transcriptase/RNaseH
(Human immunodeficiency virus 1) | BDBM50540697
(CHEMBL4633074)Show SMILES CCOC(=O)c1cc(n[nH]1)-c1cn(Cc2ccc(F)cc2)cc1-c1ccc(OCC(=O)Nc2ccc(cc2)C(O)=O)cc1 Show InChI InChI=1S/C32H27FN4O6/c1-2-42-32(41)29-15-28(35-36-29)27-18-37(16-20-3-9-23(33)10-4-20)17-26(27)21-7-13-25(14-8-21)43-19-30(38)34-24-11-5-22(6-12-24)31(39)40/h3-15,17-18H,2,16,19H2,1H3,(H,34,38)(H,35,36)(H,39,40) | PDB
MMDB
UniProtKB/TrEMBL
B.MOAD
DrugBank
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 8.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
"Sapienza" Universit£ di Roma
Curated by ChEMBL
| Assay Description
Inhibition of RNase H activity of recombinant His-tagged HIV-1 group M subtype B reverse transcriptase p66/p51 expressed in Escherichia coli M15 usin... |
ACS Med Chem Lett 11: 798-805 (2020)
Article DOI: 10.1021/acsmedchemlett.9b00617
BindingDB Entry DOI: 10.7270/Q2T1576W |
More data for this
Ligand-Target Pair | |
Reverse transcriptase/RNaseH
(Human immunodeficiency virus 1) | BDBM50587967
(CHEMBL5197780)Show SMILES OC(=O)c1cn(Cc2ccc(F)cc2)c2ccc(OCc3cccc(Cl)c3Cl)cc2c1=O | PDB
MMDB
UniProtKB/TrEMBL
B.MOAD
DrugBank
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 8.19E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.1c00535
BindingDB Entry DOI: 10.7270/Q2V98D1X |
More data for this
Ligand-Target Pair | |
Reverse transcriptase/RNaseH
(Human immunodeficiency virus 1) | BDBM50587972
(CHEMBL5202973)Show SMILES OC(=O)c1cn(Cc2ccc(F)cc2)c2ccc(OCCCCc3ccccc3)cc2c1=O | PDB
MMDB
UniProtKB/TrEMBL
B.MOAD
DrugBank
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 8.27E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.1c00535
BindingDB Entry DOI: 10.7270/Q2V98D1X |
More data for this
Ligand-Target Pair | |
Reverse transcriptase/RNaseH
(Human immunodeficiency virus 1) | BDBM50540694
(CHEMBL4640576)Show SMILES CCOC(=O)c1cc(n[nH]1)-c1cn(Cc2cccc3ccccc23)cc1-c1ccc(OCCCCc2ccccc2)cc1 Show InChI InChI=1S/C37H35N3O3/c1-2-42-37(41)36-23-35(38-39-36)34-26-40(24-30-16-10-15-28-14-6-7-17-32(28)30)25-33(34)29-18-20-31(21-19-29)43-22-9-8-13-27-11-4-3-5-12-27/h3-7,10-12,14-21,23,25-26H,2,8-9,13,22,24H2,1H3,(H,38,39) | PDB
MMDB
UniProtKB/TrEMBL
B.MOAD
DrugBank
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 8.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
"Sapienza" Universit£ di Roma
Curated by ChEMBL
| Assay Description
Inhibition of RNase H activity of recombinant His-tagged HIV-1 group M subtype B reverse transcriptase p66/p51 expressed in Escherichia coli M15 usin... |
ACS Med Chem Lett 11: 798-805 (2020)
Article DOI: 10.1021/acsmedchemlett.9b00617
BindingDB Entry DOI: 10.7270/Q2T1576W |
More data for this
Ligand-Target Pair | |
Reverse transcriptase/RNaseH
(Human immunodeficiency virus 1) | BDBM50540709
(CHEMBL4642283)Show SMILES OC(=O)c1cc(n[nH]1)-c1cn(Cc2ccc(F)cc2)cc1-c1ccc(OCCCCCc2ccccc2)cc1 Show InChI InChI=1S/C32H30FN3O3/c33-26-14-10-24(11-15-26)20-36-21-28(29(22-36)30-19-31(32(37)38)35-34-30)25-12-16-27(17-13-25)39-18-6-2-5-9-23-7-3-1-4-8-23/h1,3-4,7-8,10-17,19,21-22H,2,5-6,9,18,20H2,(H,34,35)(H,37,38) | PDB
MMDB
UniProtKB/TrEMBL
B.MOAD
DrugBank
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 9.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
"Sapienza" Universit£ di Roma
Curated by ChEMBL
| Assay Description
Inhibition of RNase H activity of recombinant His-tagged HIV-1 group M subtype B reverse transcriptase p66/p51 expressed in Escherichia coli M15 usin... |
ACS Med Chem Lett 11: 798-805 (2020)
Article DOI: 10.1021/acsmedchemlett.9b00617
BindingDB Entry DOI: 10.7270/Q2T1576W |
More data for this
Ligand-Target Pair | |
Reverse transcriptase/RNaseH
(Human immunodeficiency virus 1) | BDBM50540679
(CHEMBL4642836)Show SMILES CCOC(=O)c1cc(n[nH]1)-c1cn(Cc2ccc(F)cc2)cc1-c1ccc2ccccc2c1 Show InChI InChI=1S/C27H22FN3O2/c1-2-33-27(32)26-14-25(29-30-26)24-17-31(15-18-7-11-22(28)12-8-18)16-23(24)21-10-9-19-5-3-4-6-20(19)13-21/h3-14,16-17H,2,15H2,1H3,(H,29,30) | PDB
MMDB
UniProtKB/TrEMBL
B.MOAD
DrugBank
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 9.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
"Sapienza" Universit£ di Roma
Curated by ChEMBL
| Assay Description
Inhibition of RNase H activity of recombinant His-tagged HIV-1 group M subtype B reverse transcriptase p66/p51 expressed in Escherichia coli M15 usin... |
ACS Med Chem Lett 11: 798-805 (2020)
Article DOI: 10.1021/acsmedchemlett.9b00617
BindingDB Entry DOI: 10.7270/Q2T1576W |
More data for this
Ligand-Target Pair | |
Reverse transcriptase/RNaseH
(Human immunodeficiency virus 1) | BDBM50540677
(CHEMBL4647376)Show SMILES CCOC(=O)c1cc(n[nH]1)-c1cn(Cc2cccc3ccccc23)cc1-c1ccccc1 Show InChI InChI=1S/C27H23N3O2/c1-2-32-27(31)26-15-25(28-29-26)24-18-30(17-23(24)20-9-4-3-5-10-20)16-21-13-8-12-19-11-6-7-14-22(19)21/h3-15,17-18H,2,16H2,1H3,(H,28,29) | PDB
MMDB
UniProtKB/TrEMBL
B.MOAD
DrugBank
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 9.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
"Sapienza" Universit£ di Roma
Curated by ChEMBL
| Assay Description
Inhibition of RNase H activity of recombinant His-tagged HIV-1 group M subtype B reverse transcriptase p66/p51 expressed in Escherichia coli M15 usin... |
ACS Med Chem Lett 11: 798-805 (2020)
Article DOI: 10.1021/acsmedchemlett.9b00617
BindingDB Entry DOI: 10.7270/Q2T1576W |
More data for this
Ligand-Target Pair | |
Integrase
(Human immunodeficiency virus 1) | BDBM50587989
(CHEMBL5191403)Show SMILES CCOC(=O)c1cn(Cc2ccc(F)cc2)c2ccc(OCc3ccc(Cl)c(Cl)c3)cc2c1=O | PDB
MMDB
UniProtKB/TrEMBL
B.MOAD
DrugBank
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 9.45E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.1c00535
BindingDB Entry DOI: 10.7270/Q2V98D1X |
More data for this
Ligand-Target Pair | |
Reverse transcriptase/RNaseH
(Human immunodeficiency virus 1) | BDBM50076167
(CHEMBL3415832)Show SMILES CCOC(=O)C(\O)=C\C(=O)c1cn(Cc2ccc(F)cc2)cc1-c1ccccc1 Show InChI InChI=1S/C23H20FNO4/c1-2-29-23(28)22(27)12-21(26)20-15-25(13-16-8-10-18(24)11-9-16)14-19(20)17-6-4-3-5-7-17/h3-12,14-15,27H,2,13H2,1H3/b22-12- | PDB
MMDB
UniProtKB/TrEMBL
B.MOAD
DrugBank
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
"Sapienza" Universit£ di Roma
Curated by ChEMBL
| Assay Description
Inhibition of RNase H activity of recombinant His-tagged HIV-1 group M subtype B reverse transcriptase p66/p51 expressed in Escherichia coli M15 usin... |
ACS Med Chem Lett 11: 798-805 (2020)
Article DOI: 10.1021/acsmedchemlett.9b00617
BindingDB Entry DOI: 10.7270/Q2T1576W |
More data for this
Ligand-Target Pair | |
Reverse transcriptase/RNaseH
(Human immunodeficiency virus 1) | BDBM50587977
(CHEMBL5194402)Show SMILES CCOC(=O)c1cn(Cc2ccc(F)cc2)c2ccc(cc2c1=O)C(C)=O | PDB
MMDB
UniProtKB/TrEMBL
B.MOAD
DrugBank
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 1.10E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.1c00535
BindingDB Entry DOI: 10.7270/Q2V98D1X |
More data for this
Ligand-Target Pair | |
Reverse transcriptase/RNaseH
(Human immunodeficiency virus 1) | BDBM50587969
(CHEMBL5173288)Show SMILES OC(=O)c1cn(Cc2ccc(F)cc2)c2ccc(OCc3cccc4ccccc34)cc2c1=O | PDB
MMDB
UniProtKB/TrEMBL
B.MOAD
DrugBank
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 1.14E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.1c00535
BindingDB Entry DOI: 10.7270/Q2V98D1X |
More data for this
Ligand-Target Pair | |
Reverse transcriptase/RNaseH
(Human immunodeficiency virus 1) | BDBM50587973
(CHEMBL5198310)Show SMILES OC(=O)c1cn(Cc2ccc(F)cc2)c2ccc(OCc3ccc(cc3)-c3ccccc3)cc2c1=O | PDB
MMDB
UniProtKB/TrEMBL
B.MOAD
DrugBank
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 1.16E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.1c00535
BindingDB Entry DOI: 10.7270/Q2V98D1X |
More data for this
Ligand-Target Pair | |
Reverse transcriptase/RNaseH
(Human immunodeficiency virus 1) | BDBM50587971
(CHEMBL5183730)Show SMILES OC(=O)c1cn(Cc2ccc(F)cc2)c2ccc(OCc3ccc4OCOc4c3)cc2c1=O | PDB
MMDB
UniProtKB/TrEMBL
B.MOAD
DrugBank
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 1.35E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.1c00535
BindingDB Entry DOI: 10.7270/Q2V98D1X |
More data for this
Ligand-Target Pair | |
Reverse transcriptase/RNaseH
(Human immunodeficiency virus 1) | BDBM50540687
(CHEMBL4649140)Show SMILES OC(=O)c1cc(n[nH]1)-c1cn(Cc2ccc(F)cc2)cc1-c1ccc2ccccc2c1 Show InChI InChI=1S/C25H18FN3O2/c26-20-9-5-16(6-10-20)13-29-14-21(19-8-7-17-3-1-2-4-18(17)11-19)22(15-29)23-12-24(25(30)31)28-27-23/h1-12,14-15H,13H2,(H,27,28)(H,30,31) | PDB
MMDB
UniProtKB/TrEMBL
B.MOAD
DrugBank
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 1.37E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
"Sapienza" Universit£ di Roma
Curated by ChEMBL
| Assay Description
Inhibition of RNase H activity of recombinant His-tagged HIV-1 group M subtype B reverse transcriptase p66/p51 expressed in Escherichia coli M15 usin... |
ACS Med Chem Lett 11: 798-805 (2020)
Article DOI: 10.1021/acsmedchemlett.9b00617
BindingDB Entry DOI: 10.7270/Q2T1576W |
More data for this
Ligand-Target Pair | |
Reverse transcriptase/RNaseH
(Human immunodeficiency virus 1) | BDBM50540672
(CHEMBL4642985)Show SMILES CCOC(=O)c1cc(n[nH]1)-c1cn(Cc2ccc(F)cc2)cc1-c1ccccc1 Show InChI InChI=1S/C23H20FN3O2/c1-2-29-23(28)22-12-21(25-26-22)20-15-27(13-16-8-10-18(24)11-9-16)14-19(20)17-6-4-3-5-7-17/h3-12,14-15H,2,13H2,1H3,(H,25,26) | PDB
MMDB
UniProtKB/TrEMBL
B.MOAD
DrugBank
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 1.43E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
"Sapienza" Universit£ di Roma
Curated by ChEMBL
| Assay Description
Inhibition of RNase H activity of recombinant His-tagged HIV-1 group M subtype B reverse transcriptase p66/p51 expressed in Escherichia coli M15 usin... |
ACS Med Chem Lett 11: 798-805 (2020)
Article DOI: 10.1021/acsmedchemlett.9b00617
BindingDB Entry DOI: 10.7270/Q2T1576W |
More data for this
Ligand-Target Pair | |
Reverse transcriptase/RNaseH
(Human immunodeficiency virus 1) | BDBM50587992
(CHEMBL5187082)Show SMILES CCOC(=O)c1cn(Cc2ccc(F)cc2)c2ccc(\C=C\C(=O)c3ccccc3)cc2c1=O | PDB
MMDB
UniProtKB/TrEMBL
B.MOAD
DrugBank
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 1.53E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.1c00535
BindingDB Entry DOI: 10.7270/Q2V98D1X |
More data for this
Ligand-Target Pair | |
Reverse transcriptase/RNaseH
(Human immunodeficiency virus 1) | BDBM50587964
(CHEMBL5187446)Show SMILES CN(C)CCCOc1ccc2n(Cc3ccc(F)cc3)cc(C(O)=O)c(=O)c2c1 | PDB
MMDB
UniProtKB/TrEMBL
B.MOAD
DrugBank
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 1.54E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.1c00535
BindingDB Entry DOI: 10.7270/Q2V98D1X |
More data for this
Ligand-Target Pair | |
Reverse transcriptase/RNaseH
(Human immunodeficiency virus 1) | BDBM50587958
(CHEMBL5207303)Show SMILES CC(=O)c1ccc2n(Cc3ccc(F)cc3)cc(C(O)=O)c(=O)c2c1 | PDB
MMDB
UniProtKB/TrEMBL
B.MOAD
DrugBank
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 1.63E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.1c00535
BindingDB Entry DOI: 10.7270/Q2V98D1X |
More data for this
Ligand-Target Pair | |
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