Reaction Details |
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Target | Reverse transcriptase/RNaseH |
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Ligand | BDBM50540672 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1982604 (CHEMBL4615866) |
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IC50 | 14300±n/a nM |
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Citation | Messore, A; Corona, A; Madia, VN; Saccoliti, F; Tudino, V; De Leo, A; Scipione, L; De Vita, D; Amendola, G; Di Maro, S; Novellino, E; Cosconati, S; Métifiot, M; Andreola, ML; Valenti, P; Esposito, F; Grandi, N; Tramontano, E; Costi, R; Di Santo, R Pyrrolyl Pyrazoles as Non-Diketo Acid Inhibitors of the HIV-1 Ribonuclease H Function of Reverse Transcriptase. ACS Med Chem Lett11:798-805 (2020) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Reverse transcriptase/RNaseH |
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Name: | Reverse transcriptase/RNaseH |
Synonyms: | HIV-1 Reverse Transcriptase RNase H | Human immunodeficiency virus type 1 reverse transcriptase | Reverse transcriptase/RNaseH |
Type: | PROTEIN |
Mol. Mass.: | 65229.15 |
Organism: | Human immunodeficiency virus 1 |
Description: | ChEMBL_1473730 |
Residue: | 566 |
Sequence: | PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV
FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKRKSVTVLDVGDAYFSVPL
DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI
YQYMDDLYVGSDLEIGQHRTKIEELRQHLLRWGLTTPDKKHQKEPPFLWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIRVRQLCKLLRGTKALTEVIPLTEEAE
LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLRTGKYARMRGA
HTNDVKQLTEAVQKITTESIVIWGKTPKFKLPIQKETWETWWTEYWQATWIPEWEFVNTP
PLVKLWYQLEKEPIVGAETFYVDGAANRETKLGKAGYVTNRGRQKVVTLTDTTNQKTELQ
AIYLALQDSGLEVNIVTDSQYALGIIQAQPDQSESELVNQIIEQLIKKEKVYLAWVPAHK
GIGGNEQVDKLVSAGIRKVLFLDGID
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BDBM50540672 |
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n/a |
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Name | BDBM50540672 |
Synonyms: | CHEMBL4642985 |
Type | Small organic molecule |
Emp. Form. | C23H20FN3O2 |
Mol. Mass. | 389.4222 |
SMILES | CCOC(=O)c1cc(n[nH]1)-c1cn(Cc2ccc(F)cc2)cc1-c1ccccc1 |
Structure |
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