Compile Data Set for Download or QSAR

Found 272 hits with Last Name = 'hwang' and Initial = 'hj'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM138204 (US8871778, 161) Show SMILES Cc1nn(cc1CN1CC(O)C1)-c1ccnc(Nc2ccc3n(C)nc(Cl)c3c2)n1 Show InChI InChI=1S/C20H21ClN8O/c1-12-13(8-28-10-15(30)11-28)9-29(25-12)18-5-6-22-20(24-18)23-14-3-4-17-16(7-14)19(21)26-27(17)2/h3-7,9,15,30H,8,10-11H2,1-2H3,(H,22,23,24)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	0.700	n/a	n/a	n/a	n/a	n/a	25
Kangwon National University Curated by ChEMBL					Assay Description Inhibition of purified full-length human SYK pre-incubated for 30 mins at room temperature before Ulight-TK peptide substrate addition and measured 1...				Bioorg Med Chem Lett 25: 4441-6 (2015) Article DOI: 10.1016/j.bmcl.2015.09.011 BindingDB Entry DOI: 10.7270/Q22Z17BN
					More data for this Ligand-Target Pair				3D Structure (crystal)
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM138201 (US8871778, 144) Show SMILES Cc1nn(cc1CN1CC(O)C1)-c1ccnc(Nc2ccc3n(C)cc(Cl)c3c2)n1 Show InChI InChI=1S/C21H22ClN7O/c1-13-14(8-28-10-16(30)11-28)9-29(26-13)20-5-6-23-21(25-20)24-15-3-4-19-17(7-15)18(22)12-27(19)2/h3-7,9,12,16,30H,8,10-11H2,1-2H3,(H,23,24,25)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.700	n/a	n/a	n/a	n/a	n/a	25
Kangwon National University Curated by ChEMBL					Assay Description Inhibition of purified full-length human SYK pre-incubated for 30 mins at room temperature before Ulight-TK peptide substrate addition and measured 1...				Bioorg Med Chem Lett 25: 4441-6 (2015) Article DOI: 10.1016/j.bmcl.2015.09.011 BindingDB Entry DOI: 10.7270/Q22Z17BN
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM138210 (US8871778, 189) Show SMILES Cc1nn(cc1CN1CC[C@@H](O)C1)-c1ccnc(Nc2ccc3n(C)c(C)c(Cl)c3c2)n1 |r| Show InChI InChI=1S/C23H26ClN7O/c1-14-16(11-30-9-7-18(32)13-30)12-31(28-14)21-6-8-25-23(27-21)26-17-4-5-20-19(10-17)22(24)15(2)29(20)3/h4-6,8,10,12,18,32H,7,9,11,13H2,1-3H3,(H,25,26,27)/t18-/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	25
Kangwon National University Curated by ChEMBL					Assay Description Inhibition of purified full-length human SYK pre-incubated for 30 mins at room temperature before Ulight-TK peptide substrate addition and measured 1...				Bioorg Med Chem Lett 25: 4441-6 (2015) Article DOI: 10.1016/j.bmcl.2015.09.011 BindingDB Entry DOI: 10.7270/Q22Z17BN
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM138200 (US8871778, 141) Show SMILES Cc1nn(cc1CN1CC(O)C1)-c1ccnc(Nc2ccc3n(C)c(C)c(Cl)c3c2)n1 Show InChI InChI=1S/C22H24ClN7O/c1-13-15(9-29-11-17(31)12-29)10-30(27-13)20-6-7-24-22(26-20)25-16-4-5-19-18(8-16)21(23)14(2)28(19)3/h4-8,10,17,31H,9,11-12H2,1-3H3,(H,24,25,26)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	25
Kangwon National University Curated by ChEMBL					Assay Description Inhibition of purified full-length human SYK pre-incubated for 30 mins at room temperature before Ulight-TK peptide substrate addition and measured 1...				Bioorg Med Chem Lett 25: 4441-6 (2015) Article DOI: 10.1016/j.bmcl.2015.09.011 BindingDB Entry DOI: 10.7270/Q22Z17BN
					More data for this Ligand-Target Pair				3D Structure (crystal)
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM50124868 (CHEMBL3622958) Show SMILES Cc1nn(cc1CN1CC(O)C1)-c1ccnc(Nc2ccc3n(C)c(C)c(C)c3c2)n1 Show InChI InChI=1S/C23H27N7O/c1-14-16(3)28(4)21-6-5-18(9-20(14)21)25-23-24-8-7-22(26-23)30-11-17(15(2)27-30)10-29-12-19(31)13-29/h5-9,11,19,31H,10,12-13H2,1-4H3,(H,24,25,26)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid PDB UniChem	PDB Article PubMed	n/a	n/a	1.70	n/a	n/a	n/a	n/a	n/a	25
Kangwon National University Curated by ChEMBL					Assay Description Inhibition of purified full-length human SYK pre-incubated for 30 mins at room temperature before Ulight-TK peptide substrate addition and measured 1...				Bioorg Med Chem Lett 25: 4441-6 (2015) Article DOI: 10.1016/j.bmcl.2015.09.011 BindingDB Entry DOI: 10.7270/Q22Z17BN
					More data for this Ligand-Target Pair				3D Structure (crystal)
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM50124761 (CHEMBL3622935) Show SMILES Cc1cc(C)cc(Nc2nccc(n2)-n2cc(CN3CC(O)C3)c(c2)C2CC2)c1 Show InChI InChI=1S/C23H27N5O/c1-15-7-16(2)9-19(8-15)25-23-24-6-5-22(26-23)28-11-18(10-27-12-20(29)13-27)21(14-28)17-3-4-17/h5-9,11,14,17,20,29H,3-4,10,12-13H2,1-2H3,(H,24,25,26)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.90	n/a	n/a	n/a	n/a	n/a	25
Kangwon National University Curated by ChEMBL					Assay Description Inhibition of purified full-length human SYK pre-incubated for 30 mins at room temperature before Ulight-TK peptide substrate addition and measured 1...				Bioorg Med Chem Lett 25: 4441-6 (2015) Article DOI: 10.1016/j.bmcl.2015.09.011 BindingDB Entry DOI: 10.7270/Q22Z17BN
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM50124705 (CHEMBL3622924) Show SMILES Cc1cn(cc1CN1CC[C@@H](O)C1)-c1ccnc(Nc2cc(C)cc(C)c2)n1 |r| Show InChI InChI=1S/C22H27N5O/c1-15-8-16(2)10-19(9-15)24-22-23-6-4-21(25-22)27-11-17(3)18(13-27)12-26-7-5-20(28)14-26/h4,6,8-11,13,20,28H,5,7,12,14H2,1-3H3,(H,23,24,25)/t20-/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.30	n/a	n/a	n/a	n/a	n/a	25
Kangwon National University Curated by ChEMBL					Assay Description Inhibition of purified full-length human SYK pre-incubated for 30 mins at room temperature before Ulight-TK peptide substrate addition and measured 1...				Bioorg Med Chem Lett 25: 4441-6 (2015) Article DOI: 10.1016/j.bmcl.2015.09.011 BindingDB Entry DOI: 10.7270/Q22Z17BN
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM50124709 (CHEMBL3622928) Show SMILES Cc1nn(cc1CN1CC[C@@H](O)C1)-c1ccnc(Nc2cc(C)cc(C)c2)n1 |r| Show InChI InChI=1S/C21H26N6O/c1-14-8-15(2)10-18(9-14)23-21-22-6-4-20(24-21)27-12-17(16(3)25-27)11-26-7-5-19(28)13-26/h4,6,8-10,12,19,28H,5,7,11,13H2,1-3H3,(H,22,23,24)/t19-/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.5	n/a	n/a	n/a	n/a	n/a	25
Kangwon National University Curated by ChEMBL					Assay Description Inhibition of purified full-length human SYK pre-incubated for 30 mins at room temperature before Ulight-TK peptide substrate addition and measured 1...				Bioorg Med Chem Lett 25: 4441-6 (2015) Article DOI: 10.1016/j.bmcl.2015.09.011 BindingDB Entry DOI: 10.7270/Q22Z17BN
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM50124756 (CHEMBL3622934) Show SMILES Cc1cc(C)cc(Nc2nccc(n2)-n2cc(CN3CC[C@@H](O)C3)c(c2)C2CC2)c1 |r| Show InChI InChI=1S/C24H29N5O/c1-16-9-17(2)11-20(10-16)26-24-25-7-5-23(27-24)29-13-19(22(15-29)18-3-4-18)12-28-8-6-21(30)14-28/h5,7,9-11,13,15,18,21,30H,3-4,6,8,12,14H2,1-2H3,(H,25,26,27)/t21-/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	3.70	n/a	n/a	n/a	n/a	n/a	25
Kangwon National University Curated by ChEMBL					Assay Description Inhibition of purified full-length human SYK pre-incubated for 30 mins at room temperature before Ulight-TK peptide substrate addition and measured 1...				Bioorg Med Chem Lett 25: 4441-6 (2015) Article DOI: 10.1016/j.bmcl.2015.09.011 BindingDB Entry DOI: 10.7270/Q22Z17BN
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM50124765 (CHEMBL3622938) Show SMILES Cc1cn(cc1CN1CC(O)C1)-c1ccnc(Nc2cc(C)c(OCCO)c(C)c2)n1 Show InChI InChI=1S/C23H29N5O3/c1-15-8-19(9-16(2)22(15)31-7-6-29)25-23-24-5-4-21(26-23)28-10-17(3)18(12-28)11-27-13-20(30)14-27/h4-5,8-10,12,20,29-30H,6-7,11,13-14H2,1-3H3,(H,24,25,26)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	25
Kangwon National University Curated by ChEMBL					Assay Description Inhibition of purified full-length human SYK pre-incubated for 30 mins at room temperature before Ulight-TK peptide substrate addition and measured 1...				Bioorg Med Chem Lett 25: 4441-6 (2015) Article DOI: 10.1016/j.bmcl.2015.09.011 BindingDB Entry DOI: 10.7270/Q22Z17BN
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM50124707 (CHEMBL3622926) Show SMILES Cc1cn(cc1CN1CC(O)C1)-c1ccnc(Nc2cc(C)cc(C)c2)n1 Show InChI InChI=1S/C21H25N5O/c1-14-6-15(2)8-18(7-14)23-21-22-5-4-20(24-21)26-9-16(3)17(11-26)10-25-12-19(27)13-25/h4-9,11,19,27H,10,12-13H2,1-3H3,(H,22,23,24)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	5.40	n/a	n/a	n/a	n/a	n/a	25
Kangwon National University Curated by ChEMBL					Assay Description Inhibition of purified full-length human SYK pre-incubated for 30 mins at room temperature before Ulight-TK peptide substrate addition and measured 1...				Bioorg Med Chem Lett 25: 4441-6 (2015) Article DOI: 10.1016/j.bmcl.2015.09.011 BindingDB Entry DOI: 10.7270/Q22Z17BN
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM50124807 (CHEMBL3622944) Show SMILES COc1c(C)cc(Nc2nccc(n2)-n2cc(C)c(CN3CC(O)C3)c2)cc1C Show InChI InChI=1S/C22H27N5O2/c1-14-7-18(8-15(2)21(14)29-4)24-22-23-6-5-20(25-22)27-9-16(3)17(11-27)10-26-12-19(28)13-26/h5-9,11,19,28H,10,12-13H2,1-4H3,(H,23,24,25)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5.70	n/a	n/a	n/a	n/a	n/a	25
Kangwon National University Curated by ChEMBL					Assay Description Inhibition of purified full-length human SYK pre-incubated for 30 mins at room temperature before Ulight-TK peptide substrate addition and measured 1...				Bioorg Med Chem Lett 25: 4441-6 (2015) Article DOI: 10.1016/j.bmcl.2015.09.011 BindingDB Entry DOI: 10.7270/Q22Z17BN
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM50124711 (CHEMBL3622930) Show SMILES CN(C)Cc1cn(cc1C)-c1ccnc(Nc2cc(C)cc(C)c2)n1 Show InChI InChI=1S/C20H25N5/c1-14-8-15(2)10-18(9-14)22-20-21-7-6-19(23-20)25-11-16(3)17(13-25)12-24(4)5/h6-11,13H,12H2,1-5H3,(H,21,22,23)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	6.20	n/a	n/a	n/a	n/a	n/a	25
Kangwon National University Curated by ChEMBL					Assay Description Inhibition of purified full-length human SYK pre-incubated for 30 mins at room temperature before Ulight-TK peptide substrate addition and measured 1...				Bioorg Med Chem Lett 25: 4441-6 (2015) Article DOI: 10.1016/j.bmcl.2015.09.011 BindingDB Entry DOI: 10.7270/Q22Z17BN
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM50124816 (CHEMBL3622945) Show SMILES Cc1cn(cc1CN1CC(O)C1)-c1ccnc(Nc2cc(C)c(OS(C)(=O)=O)c(C)c2)n1 Show InChI InChI=1S/C22H27N5O4S/c1-14-7-18(8-15(2)21(14)31-32(4,29)30)24-22-23-6-5-20(25-22)27-9-16(3)17(11-27)10-26-12-19(28)13-26/h5-9,11,19,28H,10,12-13H2,1-4H3,(H,23,24,25)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	6.30	n/a	n/a	n/a	n/a	n/a	25
Kangwon National University Curated by ChEMBL					Assay Description Inhibition of purified full-length human SYK pre-incubated for 30 mins at room temperature before Ulight-TK peptide substrate addition and measured 1...				Bioorg Med Chem Lett 25: 4441-6 (2015) Article DOI: 10.1016/j.bmcl.2015.09.011 BindingDB Entry DOI: 10.7270/Q22Z17BN
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM50124771 (CHEMBL3622940) Show SMILES Cc1cn(cc1CN1CC(O)C1)-c1ccnc(Nc2cc(C)c(OCC(=O)N3CCCC3)c(C)c2)n1 Show InChI InChI=1S/C27H34N6O3/c1-18-10-22(11-19(2)26(18)36-17-25(35)32-8-4-5-9-32)29-27-28-7-6-24(30-27)33-12-20(3)21(14-33)13-31-15-23(34)16-31/h6-7,10-12,14,23,34H,4-5,8-9,13,15-17H2,1-3H3,(H,28,29,30)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	7.30	n/a	n/a	n/a	n/a	n/a	25
Kangwon National University Curated by ChEMBL					Assay Description Inhibition of purified full-length human SYK pre-incubated for 30 mins at room temperature before Ulight-TK peptide substrate addition and measured 1...				Bioorg Med Chem Lett 25: 4441-6 (2015) Article DOI: 10.1016/j.bmcl.2015.09.011 BindingDB Entry DOI: 10.7270/Q22Z17BN
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM50124710 (CHEMBL3622929) Show SMILES Cc1nn(cc1CN1CC(O)C1)-c1ccnc(Nc2cc(C)cc(C)c2)n1 Show InChI InChI=1S/C20H24N6O/c1-13-6-14(2)8-17(7-13)22-20-21-5-4-19(23-20)26-10-16(15(3)24-26)9-25-11-18(27)12-25/h4-8,10,18,27H,9,11-12H2,1-3H3,(H,21,22,23)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	7.30	n/a	n/a	n/a	n/a	n/a	25
Kangwon National University Curated by ChEMBL					Assay Description Inhibition of purified full-length human SYK pre-incubated for 30 mins at room temperature before Ulight-TK peptide substrate addition and measured 1...				Bioorg Med Chem Lett 25: 4441-6 (2015) Article DOI: 10.1016/j.bmcl.2015.09.011 BindingDB Entry DOI: 10.7270/Q22Z17BN
					More data for this Ligand-Target Pair				3D Structure (crystal)
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM50124839 (CHEMBL3622946) Show SMILES Cc1cn(cc1CN1CC[C@@H](O)C1)-c1ccnc(Nc2cc(C)c(OS(C)(=O)=O)c(C)c2)n1 |r| Show InChI InChI=1S/C23H29N5O4S/c1-15-9-19(10-16(2)22(15)32-33(4,30)31)25-23-24-7-5-21(26-23)28-11-17(3)18(13-28)12-27-8-6-20(29)14-27/h5,7,9-11,13,20,29H,6,8,12,14H2,1-4H3,(H,24,25,26)/t20-/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	7.90	n/a	n/a	n/a	n/a	n/a	25
Kangwon National University Curated by ChEMBL					Assay Description Inhibition of purified full-length human SYK pre-incubated for 30 mins at room temperature before Ulight-TK peptide substrate addition and measured 1...				Bioorg Med Chem Lett 25: 4441-6 (2015) Article DOI: 10.1016/j.bmcl.2015.09.011 BindingDB Entry DOI: 10.7270/Q22Z17BN
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM50124869 (CHEMBL3622960) Show SMILES Cc1nn(cc1CN1CC(O)C1)-c1ccnc(Nc2ccc3n(ncc3c2)C2CC2)n1 Show InChI InChI=1S/C22H24N8O/c1-14-16(10-28-12-19(31)13-28)11-29(27-14)21-6-7-23-22(26-21)25-17-2-5-20-15(8-17)9-24-30(20)18-3-4-18/h2,5-9,11,18-19,31H,3-4,10,12-13H2,1H3,(H,23,25,26)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	8	n/a	n/a	n/a	n/a	n/a	25
Kangwon National University Curated by ChEMBL					Assay Description Inhibition of purified full-length human SYK pre-incubated for 30 mins at room temperature before Ulight-TK peptide substrate addition and measured 1...				Bioorg Med Chem Lett 25: 4441-6 (2015) Article DOI: 10.1016/j.bmcl.2015.09.011 BindingDB Entry DOI: 10.7270/Q22Z17BN
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM50124806 (CHEMBL3622943) Show SMILES Cc1nn(cc1CN1CC(O)C1)-c1ccnc(Nc2cc(C)c(OCCN3CCCC3)c(C)c2)n1 Show InChI InChI=1S/C26H35N7O2/c1-18-12-22(13-19(2)25(18)35-11-10-31-8-4-5-9-31)28-26-27-7-6-24(29-26)33-15-21(20(3)30-33)14-32-16-23(34)17-32/h6-7,12-13,15,23,34H,4-5,8-11,14,16-17H2,1-3H3,(H,27,28,29)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	8.90	n/a	n/a	n/a	n/a	n/a	25
Kangwon National University Curated by ChEMBL					Assay Description Inhibition of purified full-length human SYK pre-incubated for 30 mins at room temperature before Ulight-TK peptide substrate addition and measured 1...				Bioorg Med Chem Lett 25: 4441-6 (2015) Article DOI: 10.1016/j.bmcl.2015.09.011 BindingDB Entry DOI: 10.7270/Q22Z17BN
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM50124866 (CHEMBL3622953) Show SMILES CCn1ccc2cc(Nc3nccc(n3)-n3cc(CN4CC(O)C4)c(n3)C3CC3)ccc12 Show InChI InChI=1S/C24H27N7O/c1-2-30-10-8-17-11-19(5-6-21(17)30)26-24-25-9-7-22(27-24)31-13-18(12-29-14-20(32)15-29)23(28-31)16-3-4-16/h5-11,13,16,20,32H,2-4,12,14-15H2,1H3,(H,25,26,27)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	9.20	n/a	n/a	n/a	n/a	n/a	25
Kangwon National University Curated by ChEMBL					Assay Description Inhibition of purified full-length human SYK pre-incubated for 30 mins at room temperature before Ulight-TK peptide substrate addition and measured 1...				Bioorg Med Chem Lett 25: 4441-6 (2015) Article DOI: 10.1016/j.bmcl.2015.09.011 BindingDB Entry DOI: 10.7270/Q22Z17BN
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM50124781 (CHEMBL3622942) Show SMILES Cc1cn(cc1CN1CC(O)C1)-c1ccnc(Nc2cc(C)c(OCCN3CCCC3)c(C)c2)n1 Show InChI InChI=1S/C27H36N6O2/c1-19-12-23(13-20(2)26(19)35-11-10-31-8-4-5-9-31)29-27-28-7-6-25(30-27)33-14-21(3)22(16-33)15-32-17-24(34)18-32/h6-7,12-14,16,24,34H,4-5,8-11,15,17-18H2,1-3H3,(H,28,29,30)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	12	n/a	n/a	n/a	n/a	n/a	25
Kangwon National University Curated by ChEMBL					Assay Description Inhibition of purified full-length human SYK pre-incubated for 30 mins at room temperature before Ulight-TK peptide substrate addition and measured 1...				Bioorg Med Chem Lett 25: 4441-6 (2015) Article DOI: 10.1016/j.bmcl.2015.09.011 BindingDB Entry DOI: 10.7270/Q22Z17BN
					More data for this Ligand-Target Pair				3D Structure (crystal)
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM50124763 (CHEMBL3622936) Show SMILES Cc1cn(cc1CN1CC[C@@H](N)C1)-c1ccnc(Nc2cc(C)cc(C)c2)n1 |r| Show InChI InChI=1S/C22H28N6/c1-15-8-16(2)10-20(9-15)25-22-24-6-4-21(26-22)28-11-17(3)18(13-28)12-27-7-5-19(23)14-27/h4,6,8-11,13,19H,5,7,12,14,23H2,1-3H3,(H,24,25,26)/t19-/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	13	n/a	n/a	n/a	n/a	n/a	25
Kangwon National University Curated by ChEMBL					Assay Description Inhibition of purified full-length human SYK pre-incubated for 30 mins at room temperature before Ulight-TK peptide substrate addition and measured 1...				Bioorg Med Chem Lett 25: 4441-6 (2015) Article DOI: 10.1016/j.bmcl.2015.09.011 BindingDB Entry DOI: 10.7270/Q22Z17BN
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM50124778 (CHEMBL3622941) Show SMILES Cc1cn(cc1CN1CC[C@@H](O)C1)-c1ccnc(Nc2cc(C)c(OCC(=O)N3CCCC3)c(C)c2)n1 |r| Show InChI InChI=1S/C28H36N6O3/c1-19-12-23(13-20(2)27(19)37-18-26(36)33-9-4-5-10-33)30-28-29-8-6-25(31-28)34-14-21(3)22(16-34)15-32-11-7-24(35)17-32/h6,8,12-14,16,24,35H,4-5,7,9-11,15,17-18H2,1-3H3,(H,29,30,31)/t24-/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	14	n/a	n/a	n/a	n/a	n/a	25
Kangwon National University Curated by ChEMBL					Assay Description Inhibition of purified full-length human SYK pre-incubated for 30 mins at room temperature before Ulight-TK peptide substrate addition and measured 1...				Bioorg Med Chem Lett 25: 4441-6 (2015) Article DOI: 10.1016/j.bmcl.2015.09.011 BindingDB Entry DOI: 10.7270/Q22Z17BN
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM50124769 (CHEMBL3622939) Show SMILES Cc1cn(cc1CN1CC[C@@H](O)C1)-c1ccnc(Nc2cc(C)c(OCCO)c(C)c2)n1 |r| Show InChI InChI=1S/C24H31N5O3/c1-16-10-20(11-17(2)23(16)32-9-8-30)26-24-25-6-4-22(27-24)29-12-18(3)19(14-29)13-28-7-5-21(31)15-28/h4,6,10-12,14,21,30-31H,5,7-9,13,15H2,1-3H3,(H,25,26,27)/t21-/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	17	n/a	n/a	n/a	n/a	n/a	25
Kangwon National University Curated by ChEMBL					Assay Description Inhibition of purified full-length human SYK pre-incubated for 30 mins at room temperature before Ulight-TK peptide substrate addition and measured 1...				Bioorg Med Chem Lett 25: 4441-6 (2015) Article DOI: 10.1016/j.bmcl.2015.09.011 BindingDB Entry DOI: 10.7270/Q22Z17BN
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM50124764 (CHEMBL3622937) Show SMILES Cc1cn(cc1CN1CC[C@@H](C1)C(O)=O)-c1ccnc(Nc2cc(C)cc(C)c2)n1 |r| Show InChI InChI=1S/C23H27N5O2/c1-15-8-16(2)10-20(9-15)25-23-24-6-4-21(26-23)28-11-17(3)19(14-28)13-27-7-5-18(12-27)22(29)30/h4,6,8-11,14,18H,5,7,12-13H2,1-3H3,(H,29,30)(H,24,25,26)/t18-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	18	n/a	n/a	n/a	n/a	n/a	25
Kangwon National University Curated by ChEMBL					Assay Description Inhibition of purified full-length human SYK pre-incubated for 30 mins at room temperature before Ulight-TK peptide substrate addition and measured 1...				Bioorg Med Chem Lett 25: 4441-6 (2015) Article DOI: 10.1016/j.bmcl.2015.09.011 BindingDB Entry DOI: 10.7270/Q22Z17BN
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM50124865 (CHEMBL3622951) Show SMILES CN1CCc2cc(Nc3nccc(n3)-n3cc(CN4CC(O)C4)c(C)n3)ccc12 Show InChI InChI=1S/C21H25N7O/c1-14-16(10-27-12-18(29)13-27)11-28(25-14)20-5-7-22-21(24-20)23-17-3-4-19-15(9-17)6-8-26(19)2/h3-5,7,9,11,18,29H,6,8,10,12-13H2,1-2H3,(H,22,23,24)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	20	n/a	n/a	n/a	n/a	n/a	25
Kangwon National University Curated by ChEMBL					Assay Description Inhibition of purified full-length human SYK pre-incubated for 30 mins at room temperature before Ulight-TK peptide substrate addition and measured 1...				Bioorg Med Chem Lett 25: 4441-6 (2015) Article DOI: 10.1016/j.bmcl.2015.09.011 BindingDB Entry DOI: 10.7270/Q22Z17BN
					More data for this Ligand-Target Pair
Estrogen-related receptor gamma (Homo sapiens (Human))	BDBM50193253 (CHEMBL3961676) Show SMILES Cl.CN(C)CCOc1ccc(cc1)C(=C(\CCCF)c1ccccc1)\c1ccc(O)cc1 Show InChI InChI=1S/C27H30FNO2.ClH/c1-29(2)19-20-31-25-16-12-23(13-17-25)27(22-10-14-24(30)15-11-22)26(9-6-18-28)21-7-4-3-5-8-21;/h3-5,7-8,10-17,30H,6,9,18-20H2,1-2H3;1H/b27-26-;	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	20	n/a	n/a	n/a	n/a	n/a	n/a
Daegu-Gyeongbuk Medical Innovation Foundation Curated by ChEMBL					Assay Description Inhibition of fluorescien-conjugated coactivator PGC1a binding to GST-tagged human ERRgamma LBD after 1 hr by TR-FRET assay				Eur J Med Chem 120: 338-52 (2016) Article DOI: 10.1016/j.ejmech.2016.04.076 BindingDB Entry DOI: 10.7270/Q2TH8PN2
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM138203 (US8871778, 160) Show SMILES Cc1nn(cc1CN1CC(O)C1)-c1ccnc(Nc2ccc3n(C)ncc3c2)n1 Show InChI InChI=1S/C20H22N8O/c1-13-15(9-27-11-17(29)12-27)10-28(25-13)19-5-6-21-20(24-19)23-16-3-4-18-14(7-16)8-22-26(18)2/h3-8,10,17,29H,9,11-12H2,1-2H3,(H,21,23,24)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	20	n/a	n/a	n/a	n/a	n/a	25
Kangwon National University Curated by ChEMBL					Assay Description Inhibition of purified full-length human SYK pre-incubated for 30 mins at room temperature before Ulight-TK peptide substrate addition and measured 1...				Bioorg Med Chem Lett 25: 4441-6 (2015) Article DOI: 10.1016/j.bmcl.2015.09.011 BindingDB Entry DOI: 10.7270/Q22Z17BN
					More data for this Ligand-Target Pair				3D Structure (crystal)
Estrogen receptor (Homo sapiens (Human))	BDBM50193253 (CHEMBL3961676) Show SMILES Cl.CN(C)CCOc1ccc(cc1)C(=C(\CCCF)c1ccccc1)\c1ccc(O)cc1 Show InChI InChI=1S/C27H30FNO2.ClH/c1-29(2)19-20-31-25-16-12-23(13-17-25)27(22-10-14-24(30)15-11-22)26(9-6-18-28)21-7-4-3-5-8-21;/h3-5,7-8,10-17,30H,6,9,18-20H2,1-2H3;1H/b27-26-;	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	20	n/a	n/a	n/a	n/a	n/a	n/a
Daegu-Gyeongbuk Medical Innovation Foundation Curated by ChEMBL					Assay Description Inhibition of fluorescien-conjugated coactivator PGC1a binding to ERalpha (unknown origin) after 1 hr by TR-FRET assay				Eur J Med Chem 120: 338-52 (2016) Article DOI: 10.1016/j.ejmech.2016.04.076 BindingDB Entry DOI: 10.7270/Q2TH8PN2
					More data for this Ligand-Target Pair
Estrogen-related receptor gamma (Homo sapiens (Human))	BDBM485047 (US10934303, Cmpd No. 6g | US10934303, Example 10 |...) Show SMILES CN1CCCC1CCOc1ccc(cc1)C(=C(\CCCO)c1ccccc1)\c1ccc(O)cc1 Show InChI InChI=1S/C30H35NO3/c1-31-20-5-9-26(31)19-22-34-28-17-13-25(14-18-28)30(24-11-15-27(33)16-12-24)29(10-6-21-32)23-7-3-2-4-8-23/h2-4,7-8,11-18,26,32-33H,5-6,9-10,19-22H2,1H3/b30-29-	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	PubMed	n/a	n/a	20	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Binding affinity to GST-tagged ERRgamma LBD (unknown origin) using fluorescein PGC1alpha as coactivator incubated for 1 hr by LanthaScreen TR-FRET co...				Citation and Details BindingDB Entry DOI: 10.7270/Q23X8B8M
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM50124867 (CHEMBL3622954) Show SMILES CCn1ccc2cc(Nc3nccc(n3)-n3cc(CN4CC(O)C4)c(C)n3)ccc12 Show InChI InChI=1S/C22H25N7O/c1-3-28-9-7-16-10-18(4-5-20(16)28)24-22-23-8-6-21(25-22)29-12-17(15(2)26-29)11-27-13-19(30)14-27/h4-10,12,19,30H,3,11,13-14H2,1-2H3,(H,23,24,25)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	23	n/a	n/a	n/a	n/a	n/a	25
Kangwon National University Curated by ChEMBL					Assay Description Inhibition of purified full-length human SYK pre-incubated for 30 mins at room temperature before Ulight-TK peptide substrate addition and measured 1...				Bioorg Med Chem Lett 25: 4441-6 (2015) Article DOI: 10.1016/j.bmcl.2015.09.011 BindingDB Entry DOI: 10.7270/Q22Z17BN
					More data for this Ligand-Target Pair
Estrogen-related receptor gamma (Homo sapiens (Human))	BDBM50550304 (CHEMBL4744529) Show SMILES Cl.Cl.CN1CCC[C@@H]1CCOc1ccc(cc1)C(=C(\CCCO)c1ccccc1)\c1ccc(O)cc1 |r| Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	PubMed	n/a	n/a	26	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Binding affinity to GST-tagged ERRgamma LBD (unknown origin) using fluorescein PGC1alpha as coactivator incubated for 1 hr by LanthaScreen TR-FRET co...				Citation and Details BindingDB Entry DOI: 10.7270/Q23X8B8M
					More data for this Ligand-Target Pair
Estrogen-related receptor gamma (Homo sapiens (Human))	BDBM50550294 (CHEMBL4791981) Show SMILES Cl.CN1CCC[C@H]1COc1ccc(cc1)C(=C(\CCCO)c1ccccc1)\c1ccc(O)cc1 |r| Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	PubMed	n/a	n/a	30	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Binding affinity to GST-tagged ERRgamma LBD (unknown origin) using fluorescein PGC1alpha as coactivator incubated for 1 hr by LanthaScreen TR-FRET co...				Citation and Details BindingDB Entry DOI: 10.7270/Q23X8B8M
					More data for this Ligand-Target Pair
Estrogen-related receptor gamma (Homo sapiens (Human))	BDBM50550305 (CHEMBL4792390) Show SMILES Cl.CN1CCC[C@H]1CCOc1ccc(cc1)C(=C(\CCCO)c1ccccc1)\c1ccc(O)cc1 |r| Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	PubMed	n/a	n/a	34	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Binding affinity to GST-tagged ERRgamma LBD (unknown origin) using fluorescein PGC1alpha as coactivator incubated for 1 hr by LanthaScreen TR-FRET co...				Citation and Details BindingDB Entry DOI: 10.7270/Q23X8B8M
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM138221 (US8871778, 52) Show SMILES Cc1nn(cc1CN1CC(O)C1)-c1ccnc(Nc2ccc3n(C)ccc3c2)n1 Show InChI InChI=1S/C21H23N7O/c1-14-16(10-27-12-18(29)13-27)11-28(25-14)20-5-7-22-21(24-20)23-17-3-4-19-15(9-17)6-8-26(19)2/h3-9,11,18,29H,10,12-13H2,1-2H3,(H,22,23,24)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	37	n/a	n/a	n/a	n/a	n/a	25
Kangwon National University Curated by ChEMBL					Assay Description Inhibition of purified full-length human SYK pre-incubated for 30 mins at room temperature before Ulight-TK peptide substrate addition and measured 1...				Bioorg Med Chem Lett 25: 4441-6 (2015) Article DOI: 10.1016/j.bmcl.2015.09.011 BindingDB Entry DOI: 10.7270/Q22Z17BN
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM50124708 (CHEMBL3622927) Show SMILES COc1cc(Nc2nccc(n2)-n2cc(C)c(CN3CC(O)C3)c2)cc(OC)c1OC Show InChI InChI=1S/C22H27N5O4/c1-14-9-27(11-15(14)10-26-12-17(28)13-26)20-5-6-23-22(25-20)24-16-7-18(29-2)21(31-4)19(8-16)30-3/h5-9,11,17,28H,10,12-13H2,1-4H3,(H,23,24,25)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	38	n/a	n/a	n/a	n/a	n/a	25
Kangwon National University Curated by ChEMBL					Assay Description Inhibition of purified full-length human SYK pre-incubated for 30 mins at room temperature before Ulight-TK peptide substrate addition and measured 1...				Bioorg Med Chem Lett 25: 4441-6 (2015) Article DOI: 10.1016/j.bmcl.2015.09.011 BindingDB Entry DOI: 10.7270/Q22Z17BN
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM138200 (US8871778, 141) Show SMILES Cc1nn(cc1CN1CC(O)C1)-c1ccnc(Nc2ccc3n(C)c(C)c(Cl)c3c2)n1 Show InChI InChI=1S/C22H24ClN7O/c1-13-15(9-29-11-17(31)12-29)10-30(27-13)20-6-7-24-22(26-20)25-16-4-5-19-18(8-16)21(23)14(2)28(19)3/h4-8,10,17,31H,9,11-12H2,1-3H3,(H,24,25,26)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	38	n/a	n/a	n/a	n/a	n/a	n/a
Kangwon National University Curated by ChEMBL					Assay Description Inhibition of SYK-mediated TNFalpha production in human IgG-stimulated human THP1 cells incubated for 18 hrs by ELISA method				Bioorg Med Chem Lett 25: 4441-6 (2015) Article DOI: 10.1016/j.bmcl.2015.09.011 BindingDB Entry DOI: 10.7270/Q22Z17BN
					More data for this Ligand-Target Pair				3D Structure (crystal)
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM50124713 (CHEMBL3622932) Show SMILES Cc1nn(cc1CN1CCC(O)CC1)-c1ccnc(Nc2cc(C)cc(C)c2)n1 Show InChI InChI=1S/C22H28N6O/c1-15-10-16(2)12-19(11-15)24-22-23-7-4-21(25-22)28-14-18(17(3)26-28)13-27-8-5-20(29)6-9-27/h4,7,10-12,14,20,29H,5-6,8-9,13H2,1-3H3,(H,23,24,25)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	39	n/a	n/a	n/a	n/a	n/a	25
Kangwon National University Curated by ChEMBL					Assay Description Inhibition of purified full-length human SYK pre-incubated for 30 mins at room temperature before Ulight-TK peptide substrate addition and measured 1...				Bioorg Med Chem Lett 25: 4441-6 (2015) Article DOI: 10.1016/j.bmcl.2015.09.011 BindingDB Entry DOI: 10.7270/Q22Z17BN
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM138210 (US8871778, 189) Show SMILES Cc1nn(cc1CN1CC[C@@H](O)C1)-c1ccnc(Nc2ccc3n(C)c(C)c(Cl)c3c2)n1 |r| Show InChI InChI=1S/C23H26ClN7O/c1-14-16(11-30-9-7-18(32)13-30)12-31(28-14)21-6-8-25-23(27-21)26-17-4-5-20-19(10-17)22(24)15(2)29(20)3/h4-6,8,10,12,18,32H,7,9,11,13H2,1-3H3,(H,25,26,27)/t18-/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	44	n/a	n/a	n/a	n/a	n/a	n/a
Kangwon National University Curated by ChEMBL					Assay Description Inhibition of SYK-mediated TNFalpha production in human IgG-stimulated human THP1 cells incubated for 18 hrs by ELISA method				Bioorg Med Chem Lett 25: 4441-6 (2015) Article DOI: 10.1016/j.bmcl.2015.09.011 BindingDB Entry DOI: 10.7270/Q22Z17BN
					More data for this Ligand-Target Pair
Estrogen-related receptor gamma (Homo sapiens (Human))	BDBM50193253 (CHEMBL3961676) Show SMILES Cl.CN(C)CCOc1ccc(cc1)C(=C(\CCCF)c1ccccc1)\c1ccc(O)cc1 Show InChI InChI=1S/C27H30FNO2.ClH/c1-29(2)19-20-31-25-16-12-23(13-17-25)27(22-10-14-24(30)15-11-22)26(9-6-18-28)21-7-4-3-5-8-21;/h3-5,7-8,10-17,30H,6,9,18-20H2,1-2H3;1H/b27-26-;	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	48	n/a	n/a	n/a	n/a	n/a	n/a
Daegu-Gyeongbuk Medical Innovation Foundation Curated by ChEMBL					Assay Description Inverse agonist activity at ERRgamma (unknown origin) expressed in human AD293 cells after 24 hrs by beta-galactosidase/luciferase reporter gene assa...				Eur J Med Chem 120: 338-52 (2016) Article DOI: 10.1016/j.ejmech.2016.04.076 BindingDB Entry DOI: 10.7270/Q2TH8PN2
					More data for this Ligand-Target Pair
Estrogen-related receptor gamma (Homo sapiens (Human))	BDBM485074 (US10934303, Cmpd No. 38b | US10934303, Example 107...) Show SMILES OCCC\C(=C(/c1ccc(O)cc1)c1ccc(OCCN2CCC3(CCCC3)C2)cc1)c1ccccc1 Show InChI InChI=1S/C33H39NO3/c35-23-6-9-31(26-7-2-1-3-8-26)32(27-10-14-29(36)15-11-27)28-12-16-30(17-13-28)37-24-22-34-21-20-33(25-34)18-4-5-19-33/h1-3,7-8,10-17,35-36H,4-6,9,18-25H2/b32-31-	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	PubMed	n/a	n/a	50	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Binding affinity to GST-tagged ERRgamma LBD (unknown origin) using fluorescein PGC1alpha as coactivator incubated for 1 hr by LanthaScreen TR-FRET co...				Citation and Details BindingDB Entry DOI: 10.7270/Q23X8B8M
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM50124868 (CHEMBL3622958) Show SMILES Cc1nn(cc1CN1CC(O)C1)-c1ccnc(Nc2ccc3n(C)c(C)c(C)c3c2)n1 Show InChI InChI=1S/C23H27N7O/c1-14-16(3)28(4)21-6-5-18(9-20(14)21)25-23-24-8-7-22(26-23)30-11-17(15(2)27-30)10-29-12-19(31)13-29/h5-9,11,19,31H,10,12-13H2,1-4H3,(H,24,25,26)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid PDB UniChem	PDB Article PubMed	n/a	n/a	56	n/a	n/a	n/a	n/a	n/a	n/a
Kangwon National University Curated by ChEMBL					Assay Description Inhibition of SYK-mediated TNFalpha production in human IgG-stimulated human THP1 cells incubated for 18 hrs by ELISA method				Bioorg Med Chem Lett 25: 4441-6 (2015) Article DOI: 10.1016/j.bmcl.2015.09.011 BindingDB Entry DOI: 10.7270/Q22Z17BN
					More data for this Ligand-Target Pair				3D Structure (crystal)
Estrogen-related receptor gamma (Homo sapiens (Human))	BDBM50193250 (CHEMBL3897416) Show SMILES Cl.CN(C)CCCOc1ccc(cc1)C(=C(\CCCO)c1ccccc1)\c1ccc(O)cc1 Show InChI InChI=1S/C28H33NO3.ClH/c1-29(2)19-7-21-32-26-17-13-24(14-18-26)28(23-11-15-25(31)16-12-23)27(10-6-20-30)22-8-4-3-5-9-22;/h3-5,8-9,11-18,30-31H,6-7,10,19-21H2,1-2H3;1H/b28-27-;	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	58	n/a	n/a	n/a	n/a	n/a	n/a
Daegu-Gyeongbuk Medical Innovation Foundation Curated by ChEMBL					Assay Description Inverse agonist activity at ERRgamma (unknown origin) expressed in human AD293 cells after 24 hrs by beta-galactosidase/luciferase reporter gene assa...				Eur J Med Chem 120: 338-52 (2016) Article DOI: 10.1016/j.ejmech.2016.04.076 BindingDB Entry DOI: 10.7270/Q2TH8PN2
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM50124841 (CHEMBL3622947) Show SMILES COc1cc(Nc2nccc(n2)-n2cc(C)c(CN3CC(O)C3)c2)cc(OC)c1OCC(=O)N1CCCC1 Show InChI InChI=1S/C27H34N6O5/c1-18-12-33(14-19(18)13-31-15-21(34)16-31)24-6-7-28-27(30-24)29-20-10-22(36-2)26(23(11-20)37-3)38-17-25(35)32-8-4-5-9-32/h6-7,10-12,14,21,34H,4-5,8-9,13,15-17H2,1-3H3,(H,28,29,30)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	61	n/a	n/a	n/a	n/a	n/a	25
Kangwon National University Curated by ChEMBL					Assay Description Inhibition of purified full-length human SYK pre-incubated for 30 mins at room temperature before Ulight-TK peptide substrate addition and measured 1...				Bioorg Med Chem Lett 25: 4441-6 (2015) Article DOI: 10.1016/j.bmcl.2015.09.011 BindingDB Entry DOI: 10.7270/Q22Z17BN
					More data for this Ligand-Target Pair
Estrogen-related receptor gamma (Homo sapiens (Human))	BDBM50550299 (CHEMBL4791571) Show SMILES Cl.CN1CCC[C@H]1COc1ccc(cc1)C(=C(\CCCO)c1ccccc1)\c1ccc(Br)cc1 |r| Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	PubMed	n/a	n/a	64	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Binding affinity to GST-tagged ERRgamma LBD (unknown origin) using fluorescein PGC1alpha as coactivator incubated for 1 hr by LanthaScreen TR-FRET co...				Citation and Details BindingDB Entry DOI: 10.7270/Q23X8B8M
					More data for this Ligand-Target Pair
Estrogen-related receptor gamma (Homo sapiens (Human))	BDBM485045 (US10934303, Cmpd No. 6e | US10934303, Example 5 | ...) Show SMILES OCCC\C(=C(/c1ccc(O)cc1)c1ccc(OCCN2CCCC2)cc1)c1ccccc1 Show InChI InChI=1S/C29H33NO3/c31-21-6-9-28(23-7-2-1-3-8-23)29(24-10-14-26(32)15-11-24)25-12-16-27(17-13-25)33-22-20-30-18-4-5-19-30/h1-3,7-8,10-17,31-32H,4-6,9,18-22H2/b29-28-	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	PubMed	n/a	n/a	67	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Binding affinity to GST-tagged ERRgamma LBD (unknown origin) using fluorescein PGC1alpha as coactivator incubated for 1 hr by LanthaScreen TR-FRET co...				Citation and Details BindingDB Entry DOI: 10.7270/Q23X8B8M
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret (Homo sapiens (Human))	BDBM138200 (US8871778, 141) Show SMILES Cc1nn(cc1CN1CC(O)C1)-c1ccnc(Nc2ccc3n(C)c(C)c(Cl)c3c2)n1 Show InChI InChI=1S/C22H24ClN7O/c1-13-15(9-29-11-17(31)12-29)10-30(27-13)20-6-7-24-22(26-20)25-16-4-5-19-18(8-16)21(23)14(2)28(19)3/h4-8,10,17,31H,9,11-12H2,1-3H3,(H,24,25,26)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	68	n/a	n/a	n/a	n/a	n/a	25
Kangwon National University Curated by ChEMBL					Assay Description Inhibition of human RET pre-incubated for 30 mins at room temperature before substrate addition and measured 1 hr after substrate addition by cell fr...				Bioorg Med Chem Lett 25: 4441-6 (2015) Article DOI: 10.1016/j.bmcl.2015.09.011 BindingDB Entry DOI: 10.7270/Q22Z17BN
					More data for this Ligand-Target Pair
Estrogen-related receptor gamma (Homo sapiens (Human))	BDBM485046 (US10934303, Cmpd No. 6f | US10934303, Example 6 | ...) Show SMILES OCCC\C(=C(/c1ccc(O)cc1)c1ccc(OCCN2CC2)cc1)c1ccccc1 Show InChI InChI=1S/C27H29NO3/c29-19-4-7-26(21-5-2-1-3-6-21)27(22-8-12-24(30)13-9-22)23-10-14-25(15-11-23)31-20-18-28-16-17-28/h1-3,5-6,8-15,29-30H,4,7,16-20H2/b27-26-	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	PubMed	n/a	n/a	70	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Binding affinity to GST-tagged ERRgamma LBD (unknown origin) using fluorescein PGC1alpha as coactivator incubated for 1 hr by LanthaScreen TR-FRET co...				Citation and Details BindingDB Entry DOI: 10.7270/Q23X8B8M
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM50124712 (CHEMBL3622931) Show SMILES COc1cc(Nc2nccc(n2)-n2cc(C)c(CN(C)C)c2)cc(OC)c1OC Show InChI InChI=1S/C21H27N5O3/c1-14-11-26(13-15(14)12-25(2)3)19-7-8-22-21(24-19)23-16-9-17(27-4)20(29-6)18(10-16)28-5/h7-11,13H,12H2,1-6H3,(H,22,23,24)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	72	n/a	n/a	n/a	n/a	n/a	25
Kangwon National University Curated by ChEMBL					Assay Description Inhibition of purified full-length human SYK pre-incubated for 30 mins at room temperature before Ulight-TK peptide substrate addition and measured 1...				Bioorg Med Chem Lett 25: 4441-6 (2015) Article DOI: 10.1016/j.bmcl.2015.09.011 BindingDB Entry DOI: 10.7270/Q22Z17BN
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM50124705 (CHEMBL3622924) Show SMILES Cc1cn(cc1CN1CC[C@@H](O)C1)-c1ccnc(Nc2cc(C)cc(C)c2)n1 |r| Show InChI InChI=1S/C22H27N5O/c1-15-8-16(2)10-19(9-15)24-22-23-6-4-21(25-22)27-11-17(3)18(13-27)12-26-7-5-20(28)14-26/h4,6,8-11,13,20,28H,5,7,12,14H2,1-3H3,(H,23,24,25)/t20-/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	77	n/a	n/a	n/a	n/a	n/a	n/a
Kangwon National University Curated by ChEMBL					Assay Description Inhibition of SYK-mediated TNFalpha production in human IgG-stimulated human THP1 cells incubated for 18 hrs by ELISA method				Bioorg Med Chem Lett 25: 4441-6 (2015) Article DOI: 10.1016/j.bmcl.2015.09.011 BindingDB Entry DOI: 10.7270/Q22Z17BN
					More data for this Ligand-Target Pair

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