Found 2436 hits with Last Name = 'ii' and Initial = 'k' Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Nociceptin receptor
(Homo sapiens (Human)) | BDBM50478160
(CHEMBL260767)Show SMILES CNC(=O)Cn1c2ccccc2n(C2CCN(CC[C@H](Oc3cc(OC)ccc3C)C(C)C)CC2)c1=O Show InChI InChI=1S/C29H40N4O4/c1-20(2)26(37-27-18-23(36-5)11-10-21(27)3)14-17-31-15-12-22(13-16-31)33-25-9-7-6-8-24(25)32(29(33)35)19-28(34)30-4/h6-11,18,20,22,26H,12-17,19H2,1-5H3,(H,30,34)/t26-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| PC cid
PC sid
UniChem
| Article
PubMed
| 0.501 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Organon Laboratories Ltd
Curated by ChEMBL
| Assay Description
Displacement of [3H]nociceptin from human NOP receptor expressed in CHO cells |
Bioorg Med Chem 16: 2829-51 (2008)
Article DOI: 10.1016/j.bmc.2008.01.005
BindingDB Entry DOI: 10.7270/Q2C82D2D |
More data for this
Ligand-Target Pair | |
Alpha-2C adrenergic receptor
(Homo sapiens (Human)) | BDBM50203558
(4-((6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)...)Show SMILES COc1cc2CCN(Cc3ccc(OC)c4oc(cc34)C(=O)NC3CN4CCC3CC4)Cc2cc1OC |w:23.24,TEB:22:23:26.27:30.29,(16.31,-37.39,;14.97,-38.15,;13.64,-37.38,;12.31,-38.14,;10.99,-37.37,;9.65,-38.14,;8.33,-37.37,;8.32,-35.83,;6.99,-35.06,;6.99,-33.52,;5.66,-32.75,;5.66,-31.2,;6.99,-30.43,;6.98,-28.9,;5.64,-28.13,;8.32,-31.2,;9.8,-30.71,;10.72,-31.96,;9.81,-33.22,;8.33,-32.75,;12.26,-31.95,;13.03,-33.28,;13.02,-30.61,;14.56,-30.63,;15.38,-31.75,;16.42,-30.44,;17.92,-30.34,;17.02,-29.25,;15.54,-29.36,;14.82,-27.89,;15.74,-28.65,;9.66,-35.05,;10.99,-35.83,;12.32,-35.07,;13.64,-35.84,;14.98,-35.08,;16.31,-35.85,)| Show InChI InChI=1S/C29H35N3O5/c1-34-24-5-4-20(15-32-11-8-19-12-25(35-2)26(36-3)13-21(19)16-32)22-14-27(37-28(22)24)29(33)30-23-17-31-9-6-18(23)7-10-31/h4-5,12-14,18,23H,6-11,15-17H2,1-3H3,(H,30,33) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 0.800 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Kyowa Hakko Kogyo Co. Ltd.
Curated by ChEMBL
| Assay Description
Displacement of [3H]MK912 from adrenergic Alpha-2C receptor in HepG2 cells |
Bioorg Med Chem Lett 17: 1616-21 (2007)
Article DOI: 10.1016/j.bmcl.2006.12.094
BindingDB Entry DOI: 10.7270/Q2TD9Z5F |
More data for this
Ligand-Target Pair | |
Nociceptin receptor
(Homo sapiens (Human)) | BDBM50478179
(CHEMBL260556)Show SMILES COc1ccc(C)c(OC(CCN2CCC(CC2)n2c3ccccc3n(Cc3ncn[nH]3)c2=O)C(C)C)c1 Show InChI InChI=1S/C29H38N6O3/c1-20(2)26(38-27-17-23(37-4)10-9-21(27)3)13-16-33-14-11-22(12-15-33)35-25-8-6-5-7-24(25)34(29(35)36)18-28-30-19-31-32-28/h5-10,17,19-20,22,26H,11-16,18H2,1-4H3,(H,30,31,32) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| 0.891 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Organon Laboratories Ltd
Curated by ChEMBL
| Assay Description
Displacement of [3H]nociceptin from human NOP receptor expressed in CHO cells |
Bioorg Med Chem 16: 2829-51 (2008)
Article DOI: 10.1016/j.bmc.2008.01.005
BindingDB Entry DOI: 10.7270/Q2C82D2D |
More data for this
Ligand-Target Pair | |
Nociceptin receptor
(Homo sapiens (Human)) | BDBM50478179
(CHEMBL260556)Show SMILES COc1ccc(C)c(OC(CCN2CCC(CC2)n2c3ccccc3n(Cc3ncn[nH]3)c2=O)C(C)C)c1 Show InChI InChI=1S/C29H38N6O3/c1-20(2)26(38-27-17-23(37-4)10-9-21(27)3)13-16-33-14-11-22(12-15-33)35-25-8-6-5-7-24(25)34(29(35)36)18-28-30-19-31-32-28/h5-10,17,19-20,22,26H,11-16,18H2,1-4H3,(H,30,31,32) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| 0.891 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Organon Laboratories Ltd
Curated by ChEMBL
| Assay Description
Displacement of [3H]nociceptin from human NOP receptor expressed in CHO cells |
Bioorg Med Chem 16: 2829-51 (2008)
Article DOI: 10.1016/j.bmc.2008.01.005
BindingDB Entry DOI: 10.7270/Q2C82D2D |
More data for this
Ligand-Target Pair | |
Nociceptin receptor
(Homo sapiens (Human)) | BDBM50200592
((+)-2-(3-{1-[3-(5-methoxy-2-methyl-phenoxy)-4-meth...)Show SMILES CNC(=O)Cn1c2ccccc2n(C2CCN(CCC(Oc3cc(OC)ccc3C)C(C)C)CC2)c1=O |w:19.20| Show InChI InChI=1S/C29H40N4O4/c1-20(2)26(37-27-18-23(36-5)11-10-21(27)3)14-17-31-15-12-22(13-16-31)33-25-9-7-6-8-24(25)32(29(33)35)19-28(34)30-4/h6-11,18,20,22,26H,12-17,19H2,1-5H3,(H,30,34) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 1 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Organon Laboratories Ltd
Curated by ChEMBL
| Assay Description
Displacement of [3H]nociceptin from human NOP receptor expressed in CHO cells |
Bioorg Med Chem 16: 2829-51 (2008)
Article DOI: 10.1016/j.bmc.2008.01.005
BindingDB Entry DOI: 10.7270/Q2C82D2D |
More data for this
Ligand-Target Pair | |
Nociceptin receptor
(Homo sapiens (Human)) | BDBM50478171
(CHEMBL259263)Show SMILES COc1ccc(C)c(OC(CCN2CCC(CC2)n2c3ccccc3n(Cc3cscn3)c2=O)C(C)C)c1 Show InChI InChI=1S/C30H38N4O3S/c1-21(2)28(37-29-17-25(36-4)10-9-22(29)3)13-16-32-14-11-24(12-15-32)34-27-8-6-5-7-26(27)33(30(34)35)18-23-19-38-20-31-23/h5-10,17,19-21,24,28H,11-16,18H2,1-4H3 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| 1.20 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Organon Laboratories Ltd
Curated by ChEMBL
| Assay Description
Displacement of [3H]nociceptin from human NOP receptor expressed in CHO cells |
Bioorg Med Chem 16: 2829-51 (2008)
Article DOI: 10.1016/j.bmc.2008.01.005
BindingDB Entry DOI: 10.7270/Q2C82D2D |
More data for this
Ligand-Target Pair | |
Nociceptin receptor
(Homo sapiens (Human)) | BDBM50478190
(CHEMBL260169)Show SMILES COc1ccc(C)c(OC(CCN2CCC(CC2)n2c3ccccc3n(Cc3cccs3)c2=O)C(C)C)c1 Show InChI InChI=1S/C31H39N3O3S/c1-22(2)29(37-30-20-25(36-4)12-11-23(30)3)15-18-32-16-13-24(14-17-32)34-28-10-6-5-9-27(28)33(31(34)35)21-26-8-7-19-38-26/h5-12,19-20,22,24,29H,13-18,21H2,1-4H3 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| 1.40 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Organon Laboratories Ltd
Curated by ChEMBL
| Assay Description
Displacement of [3H]nociceptin from human NOP receptor expressed in CHO cells |
Bioorg Med Chem 16: 2829-51 (2008)
Article DOI: 10.1016/j.bmc.2008.01.005
BindingDB Entry DOI: 10.7270/Q2C82D2D |
More data for this
Ligand-Target Pair | |
Nociceptin receptor
(Homo sapiens (Human)) | BDBM50478170
(CHEMBL259511)Show SMILES COc1ccc(C)c(OC(CCN2CCC(CC2)n2c3ccccc3n(Cc3ccsc3)c2=O)C(C)C)c1 Show InChI InChI=1S/C31H39N3O3S/c1-22(2)29(37-30-19-26(36-4)10-9-23(30)3)13-17-32-15-11-25(12-16-32)34-28-8-6-5-7-27(28)33(31(34)35)20-24-14-18-38-21-24/h5-10,14,18-19,21-22,25,29H,11-13,15-17,20H2,1-4H3 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| 1.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Organon Laboratories Ltd
Curated by ChEMBL
| Assay Description
Displacement of [3H]nociceptin from human NOP receptor expressed in CHO cells |
Bioorg Med Chem 16: 2829-51 (2008)
Article DOI: 10.1016/j.bmc.2008.01.005
BindingDB Entry DOI: 10.7270/Q2C82D2D |
More data for this
Ligand-Target Pair | |
Nociceptin receptor
(Homo sapiens (Human)) | BDBM50478177
(CHEMBL261839)Show SMILES COc1ccc(C)c(OC(CCN2CCC(CC2)n2c3ccccc3n(Cc3ncsn3)c2=O)C(C)C)c1 Show InChI InChI=1S/C29H37N5O3S/c1-20(2)26(37-27-17-23(36-4)10-9-21(27)3)13-16-32-14-11-22(12-15-32)34-25-8-6-5-7-24(25)33(29(34)35)18-28-30-19-38-31-28/h5-10,17,19-20,22,26H,11-16,18H2,1-4H3 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| 1.70 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Organon Laboratories Ltd
Curated by ChEMBL
| Assay Description
Displacement of [3H]nociceptin from human NOP receptor expressed in CHO cells |
Bioorg Med Chem 16: 2829-51 (2008)
Article DOI: 10.1016/j.bmc.2008.01.005
BindingDB Entry DOI: 10.7270/Q2C82D2D |
More data for this
Ligand-Target Pair | |
Alpha-2A adrenergic receptor
(Homo sapiens (Human)) | BDBM50013515
((+)-yohimbine | (16alpha,17alpha)-17-hydroxyyohimb...)Show SMILES COC(=O)[C@H]1[C@@H](O)CC[C@H]2CN3CCc4c([nH]c5ccccc45)[C@@H]3C[C@H]12 |r| Show InChI InChI=1S/C21H26N2O3/c1-26-21(25)19-15-10-17-20-14(13-4-2-3-5-16(13)22-20)8-9-23(17)11-12(15)6-7-18(19)24/h2-5,12,15,17-19,22,24H,6-11H2,1H3/t12-,15-,17-,18-,19+/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
DrugBank
MCE
KEGG
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 1.80 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Kyowa Hakko Kogyo Co. Ltd.
Curated by ChEMBL
| Assay Description
Displacement of [3H]MK-912 from adrenergic alpha2A receptor in HT29 cells |
Bioorg Med Chem Lett 17: 1616-21 (2007)
Article DOI: 10.1016/j.bmcl.2006.12.094
BindingDB Entry DOI: 10.7270/Q2TD9Z5F |
More data for this
Ligand-Target Pair | |
Alpha-2C adrenergic receptor
(Homo sapiens (Human)) | BDBM50013515
((+)-yohimbine | (16alpha,17alpha)-17-hydroxyyohimb...)Show SMILES COC(=O)[C@H]1[C@@H](O)CC[C@H]2CN3CCc4c([nH]c5ccccc45)[C@@H]3C[C@H]12 |r| Show InChI InChI=1S/C21H26N2O3/c1-26-21(25)19-15-10-17-20-14(13-4-2-3-5-16(13)22-20)8-9-23(17)11-12(15)6-7-18(19)24/h2-5,12,15,17-19,22,24H,6-11H2,1H3/t12-,15-,17-,18-,19+/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
DrugBank
MCE
KEGG
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 1.90 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Kyowa Hakko Kogyo Co. Ltd.
Curated by ChEMBL
| Assay Description
Displacement of [3H]MK912 from adrenergic Alpha-2C receptor in HepG2 cells |
Bioorg Med Chem Lett 17: 1616-21 (2007)
Article DOI: 10.1016/j.bmcl.2006.12.094
BindingDB Entry DOI: 10.7270/Q2TD9Z5F |
More data for this
Ligand-Target Pair | |
Nociceptin receptor
(Homo sapiens (Human)) | BDBM50478188
(CHEMBL411643)Show SMILES COc1ccc(C)c(OC(CCN2CCC(CC2)n2c3ccccc3n(Cn3cncn3)c2=O)C(C)C)c1 Show InChI InChI=1S/C29H38N6O3/c1-21(2)27(38-28-17-24(37-4)10-9-22(28)3)13-16-32-14-11-23(12-15-32)35-26-8-6-5-7-25(26)34(29(35)36)20-33-19-30-18-31-33/h5-10,17-19,21,23,27H,11-16,20H2,1-4H3 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| 1.90 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Organon Laboratories Ltd
Curated by ChEMBL
| Assay Description
Displacement of [3H]nociceptin from human NOP receptor expressed in CHO cells |
Bioorg Med Chem 16: 2829-51 (2008)
Article DOI: 10.1016/j.bmc.2008.01.005
BindingDB Entry DOI: 10.7270/Q2C82D2D |
More data for this
Ligand-Target Pair | |
Nociceptin receptor
(Homo sapiens (Human)) | BDBM50478166
(CHEMBL260768)Show SMILES COCCn1c2ccccc2n(C2CCN(CC[C@H](Oc3cc(OC)ccc3C)C(C)C)CC2)c1=O Show InChI InChI=1S/C29H41N3O4/c1-21(2)27(36-28-20-24(35-5)11-10-22(28)3)14-17-30-15-12-23(13-16-30)32-26-9-7-6-8-25(26)31(29(32)33)18-19-34-4/h6-11,20-21,23,27H,12-19H2,1-5H3/t27-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| 2 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Organon Laboratories Ltd
Curated by ChEMBL
| Assay Description
Displacement of [3H]nociceptin from human NOP receptor expressed in CHO cells |
Bioorg Med Chem 16: 2829-51 (2008)
Article DOI: 10.1016/j.bmc.2008.01.005
BindingDB Entry DOI: 10.7270/Q2C82D2D |
More data for this
Ligand-Target Pair | |
Nociceptin receptor
(Homo sapiens (Human)) | BDBM50478178
(CHEMBL259048)Show SMILES COc1ccc(C)c(OC(CCN2CCC(CC2)n2c3ccccc3n(Cc3ncon3)c2=O)C(C)C)c1 Show InChI InChI=1S/C29H37N5O4/c1-20(2)26(38-27-17-23(36-4)10-9-21(27)3)13-16-32-14-11-22(12-15-32)34-25-8-6-5-7-24(25)33(29(34)35)18-28-30-19-37-31-28/h5-10,17,19-20,22,26H,11-16,18H2,1-4H3 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| 2.40 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Organon Laboratories Ltd
Curated by ChEMBL
| Assay Description
Displacement of [3H]nociceptin from human NOP receptor expressed in CHO cells |
Bioorg Med Chem 16: 2829-51 (2008)
Article DOI: 10.1016/j.bmc.2008.01.005
BindingDB Entry DOI: 10.7270/Q2C82D2D |
More data for this
Ligand-Target Pair | |
Nociceptin receptor
(Homo sapiens (Human)) | BDBM50478167
(CHEMBL262064)Show SMILES COc1ccc(C)c(OC(CCN2CCC(CC2)n2c3ccccc3n(Cc3cocn3)c2=O)C(C)C)c1 Show InChI InChI=1S/C30H38N4O4/c1-21(2)28(38-29-17-25(36-4)10-9-22(29)3)13-16-32-14-11-24(12-15-32)34-27-8-6-5-7-26(27)33(30(34)35)18-23-19-37-20-31-23/h5-10,17,19-21,24,28H,11-16,18H2,1-4H3 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| 2.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Organon Laboratories Ltd
Curated by ChEMBL
| Assay Description
Displacement of [3H]nociceptin from human NOP receptor expressed in CHO cells |
Bioorg Med Chem 16: 2829-51 (2008)
Article DOI: 10.1016/j.bmc.2008.01.005
BindingDB Entry DOI: 10.7270/Q2C82D2D |
More data for this
Ligand-Target Pair | |
Nociceptin receptor
(Homo sapiens (Human)) | BDBM50478161
(CHEMBL428253)Show SMILES COc1ccc(C)c(OC(CCN2CCC(CC2)n2c3ccccc3n(Cn3cccn3)c2=O)C(C)C)c1 Show InChI InChI=1S/C30H39N5O3/c1-22(2)28(38-29-20-25(37-4)11-10-23(29)3)14-19-32-17-12-24(13-18-32)35-27-9-6-5-8-26(27)34(30(35)36)21-33-16-7-15-31-33/h5-11,15-16,20,22,24,28H,12-14,17-19,21H2,1-4H3 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| 3.30 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Organon Laboratories Ltd
Curated by ChEMBL
| Assay Description
Displacement of [3H]nociceptin from human NOP receptor expressed in CHO cells |
Bioorg Med Chem 16: 2829-51 (2008)
Article DOI: 10.1016/j.bmc.2008.01.005
BindingDB Entry DOI: 10.7270/Q2C82D2D |
More data for this
Ligand-Target Pair | |
Alpha-2C adrenergic receptor
(Homo sapiens (Human)) | BDBM50203561
((4-((6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl...)Show SMILES COc1cc2CCN(Cc3ccc(OC)c4oc(cc34)C(=O)N3CCC(CC3)N3CCCC3)Cc2cc1OC Show InChI InChI=1S/C31H39N3O5/c1-36-26-7-6-22(19-32-13-8-21-16-27(37-2)28(38-3)17-23(21)20-32)25-18-29(39-30(25)26)31(35)34-14-9-24(10-15-34)33-11-4-5-12-33/h6-7,16-18,24H,4-5,8-15,19-20H2,1-3H3 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 3.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Kyowa Hakko Kogyo Co. Ltd.
Curated by ChEMBL
| Assay Description
Displacement of [3H]MK912 from adrenergic Alpha-2C receptor in HepG2 cells |
Bioorg Med Chem Lett 17: 1616-21 (2007)
Article DOI: 10.1016/j.bmcl.2006.12.094
BindingDB Entry DOI: 10.7270/Q2TD9Z5F |
More data for this
Ligand-Target Pair | |
Nociceptin receptor
(Homo sapiens (Human)) | BDBM50478162
(CHEMBL259120)Show SMILES COc1ccc(C)c(OC(CCN2CCC(CC2)n2c3ccccc3n(Cc3c(C)noc3C)c2=O)C(C)C)c1 Show InChI InChI=1S/C32H42N4O4/c1-21(2)30(39-31-19-26(38-6)12-11-22(31)3)15-18-34-16-13-25(14-17-34)36-29-10-8-7-9-28(29)35(32(36)37)20-27-23(4)33-40-24(27)5/h7-12,19,21,25,30H,13-18,20H2,1-6H3 | PDB
Reactome pathway
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UniChem
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| 3.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Organon Laboratories Ltd
Curated by ChEMBL
| Assay Description
Displacement of [3H]nociceptin from human NOP receptor expressed in CHO cells |
Bioorg Med Chem 16: 2829-51 (2008)
Article DOI: 10.1016/j.bmc.2008.01.005
BindingDB Entry DOI: 10.7270/Q2C82D2D |
More data for this
Ligand-Target Pair | |
Nociceptin receptor
(Homo sapiens (Human)) | BDBM50478186
(CHEMBL410257)Show SMILES COc1ccc(C)c(OC(CCN2CCC(CC2)n2c3ccccc3n(Cc3c[nH]cn3)c2=O)C(C)C)c1 Show InChI InChI=1S/C30H39N5O3/c1-21(2)28(38-29-17-25(37-4)10-9-22(29)3)13-16-33-14-11-24(12-15-33)35-27-8-6-5-7-26(27)34(30(35)36)19-23-18-31-20-32-23/h5-10,17-18,20-21,24,28H,11-16,19H2,1-4H3,(H,31,32) | PDB
Reactome pathway
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UniChem
| Article
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| 3.70 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Organon Laboratories Ltd
Curated by ChEMBL
| Assay Description
Displacement of [3H]nociceptin from human NOP receptor expressed in CHO cells |
Bioorg Med Chem 16: 2829-51 (2008)
Article DOI: 10.1016/j.bmc.2008.01.005
BindingDB Entry DOI: 10.7270/Q2C82D2D |
More data for this
Ligand-Target Pair | |
Nociceptin receptor
(Homo sapiens (Human)) | BDBM50478182
(CHEMBL262062)Show SMILES COc1ccc(C)c(OC(CCN2CCC(CC2)n2c3ccccc3n(Cc3ncco3)c2=O)C(C)C)c1 Show InChI InChI=1S/C30H38N4O4/c1-21(2)27(38-28-19-24(36-4)10-9-22(28)3)13-17-32-15-11-23(12-16-32)34-26-8-6-5-7-25(26)33(30(34)35)20-29-31-14-18-37-29/h5-10,14,18-19,21,23,27H,11-13,15-17,20H2,1-4H3 | PDB
Reactome pathway
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UniChem
| Article
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| 3.90 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Organon Laboratories Ltd
Curated by ChEMBL
| Assay Description
Displacement of [3H]nociceptin from human NOP receptor expressed in CHO cells |
Bioorg Med Chem 16: 2829-51 (2008)
Article DOI: 10.1016/j.bmc.2008.01.005
BindingDB Entry DOI: 10.7270/Q2C82D2D |
More data for this
Ligand-Target Pair | |
Nociceptin receptor
(Homo sapiens (Human)) | BDBM50200595
((+)-1-(2-methoxy-ethyl)-3-{1-[3-(5-methoxy-2-methy...)Show SMILES COCCn1c2ccccc2n(C2CCN(CCC(Oc3cc(OC)ccc3C)C(C)C)CC2)c1=O |w:18.19| Show InChI InChI=1S/C29H41N3O4/c1-21(2)27(36-28-20-24(35-5)11-10-22(28)3)14-17-30-15-12-23(13-16-30)32-26-9-7-6-8-25(26)31(29(32)33)18-19-34-4/h6-11,20-21,23,27H,12-19H2,1-5H3 | PDB
Reactome pathway
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| 4.10 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Organon Laboratories Ltd
Curated by ChEMBL
| Assay Description
Displacement of [3H]nociceptin from human NOP receptor expressed in CHO cells |
Bioorg Med Chem 16: 2829-51 (2008)
Article DOI: 10.1016/j.bmc.2008.01.005
BindingDB Entry DOI: 10.7270/Q2C82D2D |
More data for this
Ligand-Target Pair | |
Nociceptin receptor
(Homo sapiens (Human)) | BDBM50478180
(CHEMBL260784)Show SMILES COc1ccc(C)c(OC(CCN2CCC(CC2)n2c3ccccc3n(Cn3ccnc3)c2=O)C(C)C)c1 Show InChI InChI=1S/C30H39N5O3/c1-22(2)28(38-29-19-25(37-4)10-9-23(29)3)13-17-32-15-11-24(12-16-32)35-27-8-6-5-7-26(27)34(30(35)36)21-33-18-14-31-20-33/h5-10,14,18-20,22,24,28H,11-13,15-17,21H2,1-4H3 | PDB
Reactome pathway
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| 4.20 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Organon Laboratories Ltd
Curated by ChEMBL
| Assay Description
Displacement of [3H]nociceptin from human NOP receptor expressed in CHO cells |
Bioorg Med Chem 16: 2829-51 (2008)
Article DOI: 10.1016/j.bmc.2008.01.005
BindingDB Entry DOI: 10.7270/Q2C82D2D |
More data for this
Ligand-Target Pair | |
Alpha-2C adrenergic receptor
(Homo sapiens (Human)) | BDBM50203553
(CHEMBL247664 | N-(2-amino-2-methylpropyl)-4-((6,7-...)Show SMILES COc1cc2CCN(Cc3ccc(OC)c4oc(cc34)C(=O)NCC(C)(C)N)Cc2cc1OC Show InChI InChI=1S/C26H33N3O5/c1-26(2,27)15-28-25(30)23-12-19-17(6-7-20(31-3)24(19)34-23)13-29-9-8-16-10-21(32-4)22(33-5)11-18(16)14-29/h6-7,10-12H,8-9,13-15,27H2,1-5H3,(H,28,30) | PDB
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| 4.20 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Kyowa Hakko Kogyo Co. Ltd.
Curated by ChEMBL
| Assay Description
Displacement of [3H]MK912 from adrenergic Alpha-2C receptor in HepG2 cells |
Bioorg Med Chem Lett 17: 1616-21 (2007)
Article DOI: 10.1016/j.bmcl.2006.12.094
BindingDB Entry DOI: 10.7270/Q2TD9Z5F |
More data for this
Ligand-Target Pair | |
Chymotrypsinogen A
(Bos taurus (bovine)) | BDBM50073123
((S)-2-[3-(4-Cyano-benzoylamino)-2,2-dimethyl-nonan...)Show SMILES CCCCCCC(NC(=O)c1ccc(cc1)C#N)C(C)(C)C(=O)N[C@@H](Cc1ccccc1)C(=O)OCC Show InChI InChI=1S/C30H39N3O4/c1-5-7-8-12-15-26(33-27(34)24-18-16-23(21-31)17-19-24)30(3,4)29(36)32-25(28(35)37-6-2)20-22-13-10-9-11-14-22/h9-11,13-14,16-19,25-26H,5-8,12,15,20H2,1-4H3,(H,32,36)(H,33,34)/t25-,26?/m0/s1 | PDB
MMDB
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| 4.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Nippon Steel Corporation
Curated by ChEMBL
| Assay Description
Compound was evaluated for inactivation of bovine alpha-Chymotrypsin Kinetic constant(Ki) |
J Med Chem 42: 312-23 (1999)
Article DOI: 10.1021/jm980562h
BindingDB Entry DOI: 10.7270/Q2930SBF |
More data for this
Ligand-Target Pair | |
Nociceptin receptor
(Homo sapiens (Human)) | BDBM50478176
(CHEMBL406647)Show SMILES COc1ccc(C)c(OC(CCN2CCC(CC2)n2c3ccccc3n(Cn3ccnc3C)c2=O)C(C)C)c1 Show InChI InChI=1S/C31H41N5O3/c1-22(2)29(39-30-20-26(38-5)11-10-23(30)3)14-18-33-16-12-25(13-17-33)36-28-9-7-6-8-27(28)35(31(36)37)21-34-19-15-32-24(34)4/h6-11,15,19-20,22,25,29H,12-14,16-18,21H2,1-5H3 | PDB
Reactome pathway
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UniChem
| Article
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| 4.90 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Organon Laboratories Ltd
Curated by ChEMBL
| Assay Description
Displacement of [3H]nociceptin from human NOP receptor expressed in CHO cells |
Bioorg Med Chem 16: 2829-51 (2008)
Article DOI: 10.1016/j.bmc.2008.01.005
BindingDB Entry DOI: 10.7270/Q2C82D2D |
More data for this
Ligand-Target Pair | |
Nociceptin receptor
(Homo sapiens (Human)) | BDBM50478165
(CHEMBL408909)Show SMILES COc1ccc(C)c(OC(CCN2CCC(CC2)n2c3ccccc3n(Cc3ccccn3)c2=O)C(C)C)c1 Show InChI InChI=1S/C32H40N4O3/c1-23(2)30(39-31-21-27(38-4)13-12-24(31)3)16-20-34-18-14-26(15-19-34)36-29-11-6-5-10-28(29)35(32(36)37)22-25-9-7-8-17-33-25/h5-13,17,21,23,26,30H,14-16,18-20,22H2,1-4H3 | PDB
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UniChem
| Article
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| 4.90 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Organon Laboratories Ltd
Curated by ChEMBL
| Assay Description
Displacement of [3H]nociceptin from human NOP receptor expressed in CHO cells |
Bioorg Med Chem 16: 2829-51 (2008)
Article DOI: 10.1016/j.bmc.2008.01.005
BindingDB Entry DOI: 10.7270/Q2C82D2D |
More data for this
Ligand-Target Pair | |
Nociceptin receptor
(Homo sapiens (Human)) | BDBM50478183
(CHEMBL259291)Show SMILES COc1ccc(C)c(OC(CCN2CCC(CC2)n2c3ccccc3n(Cc3n[nH]c(=O)[nH]3)c2=O)C(C)C)c1 Show InChI InChI=1S/C29H38N6O4/c1-19(2)25(39-26-17-22(38-4)10-9-20(26)3)13-16-33-14-11-21(12-15-33)35-24-8-6-5-7-23(24)34(29(35)37)18-27-30-28(36)32-31-27/h5-10,17,19,21,25H,11-16,18H2,1-4H3,(H2,30,31,32,36) | PDB
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| 5.90 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Organon Laboratories Ltd
Curated by ChEMBL
| Assay Description
Displacement of [3H]nociceptin from human NOP receptor expressed in CHO cells |
Bioorg Med Chem 16: 2829-51 (2008)
Article DOI: 10.1016/j.bmc.2008.01.005
BindingDB Entry DOI: 10.7270/Q2C82D2D |
More data for this
Ligand-Target Pair | |
Nociceptin receptor
(Homo sapiens (Human)) | BDBM50478187
(CHEMBL259964)Show SMILES COc1ccc(C)c(OC(CCN2CCC(CC2)n2c3ccccc3n(Cc3cnccn3)c2=O)C(C)C)c1 Show InChI InChI=1S/C31H39N5O3/c1-22(2)29(39-30-19-26(38-4)10-9-23(30)3)13-18-34-16-11-25(12-17-34)36-28-8-6-5-7-27(28)35(31(36)37)21-24-20-32-14-15-33-24/h5-10,14-15,19-20,22,25,29H,11-13,16-18,21H2,1-4H3 | PDB
Reactome pathway
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UniChem
| Article
PubMed
| 5.90 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Organon Laboratories Ltd
Curated by ChEMBL
| Assay Description
Displacement of [3H]nociceptin from human NOP receptor expressed in CHO cells |
Bioorg Med Chem 16: 2829-51 (2008)
Article DOI: 10.1016/j.bmc.2008.01.005
BindingDB Entry DOI: 10.7270/Q2C82D2D |
More data for this
Ligand-Target Pair | |
Nociceptin receptor
(Homo sapiens (Human)) | BDBM50478172
(CHEMBL259292)Show SMILES COc1ccc(C)c(OC(CCN2CCC(CC2)n2c3ccccc3n(Cc3cnn[nH]3)c2=O)C(C)C)c1 Show InChI InChI=1S/C29H38N6O3/c1-20(2)27(38-28-17-24(37-4)10-9-21(28)3)13-16-33-14-11-23(12-15-33)35-26-8-6-5-7-25(26)34(29(35)36)19-22-18-30-32-31-22/h5-10,17-18,20,23,27H,11-16,19H2,1-4H3,(H,30,31,32) | PDB
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| 7.90 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Organon Laboratories Ltd
Curated by ChEMBL
| Assay Description
Displacement of [3H]nociceptin from human NOP receptor expressed in CHO cells |
Bioorg Med Chem 16: 2829-51 (2008)
Article DOI: 10.1016/j.bmc.2008.01.005
BindingDB Entry DOI: 10.7270/Q2C82D2D |
More data for this
Ligand-Target Pair | |
Alpha-2A adrenergic receptor
(Homo sapiens (Human)) | BDBM50019848
(2-(2,3-dihydro-1,4-benzodioxin-2-yl)-4,5-dihydro-1...)Show InChI InChI=1S/C11H12N2O2/c1-2-4-9-8(3-1)14-7-10(15-9)11-12-5-6-13-11/h1-4,10H,5-7H2,(H,12,13) | PDB
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| 8 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Kyowa Hakko Kogyo Co. Ltd.
Curated by ChEMBL
| Assay Description
Displacement of [3H]MK-912 from adrenergic alpha2A receptor in HT29 cells |
Bioorg Med Chem Lett 17: 1616-21 (2007)
Article DOI: 10.1016/j.bmcl.2006.12.094
BindingDB Entry DOI: 10.7270/Q2TD9Z5F |
More data for this
Ligand-Target Pair | |
Alpha-2C adrenergic receptor
(Homo sapiens (Human)) | BDBM50203559
(2-((2-(furan-2-yl)-7-methoxybenzofuran-4-yl)methyl...)Show SMILES COc1cc2CCN(Cc3ccc(OC)c4oc(cc34)-c3ccco3)Cc2cc1OC Show InChI InChI=1S/C25H25NO5/c1-27-21-7-6-17(19-13-24(31-25(19)21)20-5-4-10-30-20)14-26-9-8-16-11-22(28-2)23(29-3)12-18(16)15-26/h4-7,10-13H,8-9,14-15H2,1-3H3 | PDB
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| 8 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Kyowa Hakko Kogyo Co. Ltd.
Curated by ChEMBL
| Assay Description
Displacement of [3H]MK912 from adrenergic Alpha-2C receptor in HepG2 cells |
Bioorg Med Chem Lett 17: 1616-21 (2007)
Article DOI: 10.1016/j.bmcl.2006.12.094
BindingDB Entry DOI: 10.7270/Q2TD9Z5F |
More data for this
Ligand-Target Pair | |
Sodium-dependent serotonin transporter
(Rattus norvegicus (rat)) | BDBM50032379
((1S,2R)-2-(aminomethyl)-N,N-diethyl-1-phenylcyclop...)Show InChI InChI=1S/C15H22N2O/c1-3-17(4-2)14(18)15(10-13(15)11-16)12-8-6-5-7-9-12/h5-9,13H,3-4,10-11,16H2,1-2H3/t13-,15+/m0/s1 | PDB
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| 8.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Hokkaido University
Curated by ChEMBL
| Assay Description
Inhibition of Serotonin transporter in cerebral cortical synaptic membrane of rats using [3H]-paroxetine |
J Med Chem 41: 3507-14 (1998)
Article DOI: 10.1021/jm980238m
BindingDB Entry DOI: 10.7270/Q2000175 |
More data for this
Ligand-Target Pair | |
Sodium-dependent serotonin transporter
(Rattus norvegicus (rat)) | BDBM50032379
((1S,2R)-2-(aminomethyl)-N,N-diethyl-1-phenylcyclop...)Show InChI InChI=1S/C15H22N2O/c1-3-17(4-2)14(18)15(10-13(15)11-16)12-8-6-5-7-9-12/h5-9,13H,3-4,10-11,16H2,1-2H3/t13-,15+/m0/s1 | PDB
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| 8.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Hokkaido University
Curated by ChEMBL
| Assay Description
Inhibition of [3H]-paroxetine binding on serotonin transporter of rat cerebral cortical synaptic membrane |
J Med Chem 39: 4844-52 (1997)
Article DOI: 10.1021/jm960495w
BindingDB Entry DOI: 10.7270/Q2M907R2 |
More data for this
Ligand-Target Pair | |
Alpha-2C adrenergic receptor
(Homo sapiens (Human)) | BDBM50203562
(4-((6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)...)Show SMILES COc1cc2CCN(Cc3ccc(OC)c4oc(cc34)C(=O)NCCN(C)C)Cc2cc1OC Show InChI InChI=1S/C26H33N3O5/c1-28(2)11-9-27-26(30)24-14-20-18(6-7-21(31-3)25(20)34-24)15-29-10-8-17-12-22(32-4)23(33-5)13-19(17)16-29/h6-7,12-14H,8-11,15-16H2,1-5H3,(H,27,30) | PDB
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| 9.40 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Kyowa Hakko Kogyo Co. Ltd.
Curated by ChEMBL
| Assay Description
Displacement of [3H]MK912 from adrenergic Alpha-2C receptor in HepG2 cells |
Bioorg Med Chem Lett 17: 1616-21 (2007)
Article DOI: 10.1016/j.bmcl.2006.12.094
BindingDB Entry DOI: 10.7270/Q2TD9Z5F |
More data for this
Ligand-Target Pair | |
Alpha-2C adrenergic receptor
(Homo sapiens (Human)) | BDBM50203557
(3-(4-((6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-...)Show SMILES COc1cc2CCN(Cc3ccc(OC)c4oc(cc34)-c3cccc(c3)C(=O)NCCN(C)C)Cc2cc1OC Show InChI InChI=1S/C32H37N3O5/c1-34(2)14-12-33-32(36)23-8-6-7-22(15-23)28-18-26-24(9-10-27(37-3)31(26)40-28)19-35-13-11-21-16-29(38-4)30(39-5)17-25(21)20-35/h6-10,15-18H,11-14,19-20H2,1-5H3,(H,33,36) | PDB
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| 9.40 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Kyowa Hakko Kogyo Co. Ltd.
Curated by ChEMBL
| Assay Description
Displacement of [3H]MK912 from adrenergic Alpha-2C receptor in HepG2 cells |
Bioorg Med Chem Lett 17: 1616-21 (2007)
Article DOI: 10.1016/j.bmcl.2006.12.094
BindingDB Entry DOI: 10.7270/Q2TD9Z5F |
More data for this
Ligand-Target Pair | |
Nociceptin receptor
(Homo sapiens (Human)) | BDBM50478181
(CHEMBL258781)Show SMILES COc1ccc(C)c(OC(CCN2CCC(CC2)n2c3ccccc3n(Cc3cccnc3)c2=O)C(C)C)c1 Show InChI InChI=1S/C32H40N4O3/c1-23(2)30(39-31-20-27(38-4)12-11-24(31)3)15-19-34-17-13-26(14-18-34)36-29-10-6-5-9-28(29)35(32(36)37)22-25-8-7-16-33-21-25/h5-12,16,20-21,23,26,30H,13-15,17-19,22H2,1-4H3 | PDB
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| 9.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Organon Laboratories Ltd
Curated by ChEMBL
| Assay Description
Displacement of [3H]nociceptin from human NOP receptor expressed in CHO cells |
Bioorg Med Chem 16: 2829-51 (2008)
Article DOI: 10.1016/j.bmc.2008.01.005
BindingDB Entry DOI: 10.7270/Q2C82D2D |
More data for this
Ligand-Target Pair | |
Alpha-2C adrenergic receptor
(Homo sapiens (Human)) | BDBM50203556
(6,7-dimethoxy-2-((7-methoxy-2-(pyridin-2-yl)benzof...)Show SMILES COc1cc2CCN(Cc3ccc(OC)c4oc(cc34)-c3ccccn3)Cc2cc1OC Show InChI InChI=1S/C26H26N2O4/c1-29-22-8-7-18(20-14-23(32-26(20)22)21-6-4-5-10-27-21)15-28-11-9-17-12-24(30-2)25(31-3)13-19(17)16-28/h4-8,10,12-14H,9,11,15-16H2,1-3H3 | PDB
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| 9.60 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Kyowa Hakko Kogyo Co. Ltd.
Curated by ChEMBL
| Assay Description
Displacement of [3H]MK912 from adrenergic Alpha-2C receptor in HepG2 cells |
Bioorg Med Chem Lett 17: 1616-21 (2007)
Article DOI: 10.1016/j.bmcl.2006.12.094
BindingDB Entry DOI: 10.7270/Q2TD9Z5F |
More data for this
Ligand-Target Pair | |
D(3) dopamine receptor
(Homo sapiens (Human)) | BDBM50001955
((-)6-Methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]qu...)Show InChI InChI=1S/C17H17NO2/c1-18-8-7-10-3-2-4-12-15(10)13(18)9-11-5-6-14(19)17(20)16(11)12/h2-6,13,19-20H,7-9H2,1H3/t13-/m1/s1 | PDB
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| 10 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Tartu
Curated by ChEMBL
| Assay Description
Displacement of [3H]raclopride from human D3 receptor expressed in HEK293 cells |
Eur J Med Chem 55: 255-61 (2012)
Article DOI: 10.1016/j.ejmech.2012.07.025
BindingDB Entry DOI: 10.7270/Q2VT1T56 |
More data for this
Ligand-Target Pair | |
Alpha-2C adrenergic receptor
(Homo sapiens (Human)) | BDBM50203554
(2-((2-(2-fluorophenyl)-7-methoxybenzofuran-4-yl)me...)Show SMILES COc1cc2CCN(Cc3ccc(OC)c4oc(cc34)-c3ccccc3F)Cc2cc1OC Show InChI InChI=1S/C27H26FNO4/c1-30-23-9-8-18(21-14-24(33-27(21)23)20-6-4-5-7-22(20)28)15-29-11-10-17-12-25(31-2)26(32-3)13-19(17)16-29/h4-9,12-14H,10-11,15-16H2,1-3H3 | PDB
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| 11 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Kyowa Hakko Kogyo Co. Ltd.
Curated by ChEMBL
| Assay Description
Displacement of [3H]MK912 from adrenergic Alpha-2C receptor in HepG2 cells |
Bioorg Med Chem Lett 17: 1616-21 (2007)
Article DOI: 10.1016/j.bmcl.2006.12.094
BindingDB Entry DOI: 10.7270/Q2TD9Z5F |
More data for this
Ligand-Target Pair | |
Nociceptin receptor
(Homo sapiens (Human)) | BDBM50478184
(CHEMBL260555)Show SMILES COc1ccc(C)c(OC(CCN2CCC(CC2)n2c3ccccc3n(Cc3ncnn3C)c2=O)C(C)C)c1 Show InChI InChI=1S/C30H40N6O3/c1-21(2)27(39-28-18-24(38-5)11-10-22(28)3)14-17-34-15-12-23(13-16-34)36-26-9-7-6-8-25(26)35(30(36)37)19-29-31-20-32-33(29)4/h6-11,18,20-21,23,27H,12-17,19H2,1-5H3 | PDB
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| 12 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Organon Laboratories Ltd
Curated by ChEMBL
| Assay Description
Displacement of [3H]nociceptin from human NOP receptor expressed in CHO cells |
Bioorg Med Chem 16: 2829-51 (2008)
Article DOI: 10.1016/j.bmc.2008.01.005
BindingDB Entry DOI: 10.7270/Q2C82D2D |
More data for this
Ligand-Target Pair | |
Sodium-dependent serotonin transporter
(Rattus norvegicus (rat)) | BDBM50054804
((1S,2R)-2-(1-Amino-ethyl)-1-phenyl-cyclopropanecar...)Show InChI InChI=1S/C16H24N2O/c1-4-18(5-2)15(19)16(11-14(16)12(3)17)13-9-7-6-8-10-13/h6-10,12,14H,4-5,11,17H2,1-3H3/t12?,14-,16+/m0/s1 | PDB
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| 14 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Hokkaido University
Curated by ChEMBL
| Assay Description
Inhibition of [3H]-paroxetine binding on serotonin transporter of rat cerebral cortical synaptic membrane |
J Med Chem 39: 4844-52 (1997)
Article DOI: 10.1021/jm960495w
BindingDB Entry DOI: 10.7270/Q2M907R2 |
More data for this
Ligand-Target Pair | |
Sodium-dependent serotonin transporter
(Rattus norvegicus (rat)) | BDBM50054804
((1S,2R)-2-(1-Amino-ethyl)-1-phenyl-cyclopropanecar...)Show InChI InChI=1S/C16H24N2O/c1-4-18(5-2)15(19)16(11-14(16)12(3)17)13-9-7-6-8-10-13/h6-10,12,14H,4-5,11,17H2,1-3H3/t12?,14-,16+/m0/s1 | PDB
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| 14 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Hokkaido University
Curated by ChEMBL
| Assay Description
Inhibition of [3H]-paroxetine binding on serotonin transporter of rat cerebral cortical synaptic membrane |
J Med Chem 39: 4844-52 (1997)
Article DOI: 10.1021/jm960495w
BindingDB Entry DOI: 10.7270/Q2M907R2 |
More data for this
Ligand-Target Pair | |
D(3) dopamine receptor
(Homo sapiens (Human)) | BDBM55121
(3-HYDROXYTYRAMINE HYDROCHLORIDE | 4-(2-aminoethyl)...)Show InChI InChI=1S/C8H11NO2/c9-4-3-6-1-2-7(10)8(11)5-6/h1-2,5,10-11H,3-4,9H2 | PDB
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| 15 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Tartu
Curated by ChEMBL
| Assay Description
Displacement of [3H]raclopride from human D3 receptor expressed in HEK293 cells |
Eur J Med Chem 55: 255-61 (2012)
Article DOI: 10.1016/j.ejmech.2012.07.025
BindingDB Entry DOI: 10.7270/Q2VT1T56 |
More data for this
Ligand-Target Pair | |
Alpha-2B adrenergic receptor
(Homo sapiens (Human)) | BDBM50013515
((+)-yohimbine | (16alpha,17alpha)-17-hydroxyyohimb...)Show SMILES COC(=O)[C@H]1[C@@H](O)CC[C@H]2CN3CCc4c([nH]c5ccccc45)[C@@H]3C[C@H]12 |r| Show InChI InChI=1S/C21H26N2O3/c1-26-21(25)19-15-10-17-20-14(13-4-2-3-5-16(13)22-20)8-9-23(17)11-12(15)6-7-18(19)24/h2-5,12,15,17-19,22,24H,6-11H2,1H3/t12-,15-,17-,18-,19+/m0/s1 | PDB
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| 15 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Kyowa Hakko Kogyo Co. Ltd.
Curated by ChEMBL
| Assay Description
Displacement of [3H]MK912 from adrenergic alpha-2B receptor expressed in COS7 cells |
Bioorg Med Chem Lett 17: 1616-21 (2007)
Article DOI: 10.1016/j.bmcl.2006.12.094
BindingDB Entry DOI: 10.7270/Q2TD9Z5F |
More data for this
Ligand-Target Pair | |
Nociceptin receptor
(Homo sapiens (Human)) | BDBM50478169
(CHEMBL406926)Show SMILES COc1ccc(C)c(OC(CCN2CCC(CC2)n2c3ccccc3n(Cc3csc(C)n3)c2=O)C(C)C)c1 Show InChI InChI=1S/C31H40N4O3S/c1-21(2)29(38-30-18-26(37-5)11-10-22(30)3)14-17-33-15-12-25(13-16-33)35-28-9-7-6-8-27(28)34(31(35)36)19-24-20-39-23(4)32-24/h6-11,18,20-21,25,29H,12-17,19H2,1-5H3 | PDB
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| 17 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Organon Laboratories Ltd
Curated by ChEMBL
| Assay Description
Displacement of [3H]nociceptin from human NOP receptor expressed in CHO cells |
Bioorg Med Chem 16: 2829-51 (2008)
Article DOI: 10.1016/j.bmc.2008.01.005
BindingDB Entry DOI: 10.7270/Q2C82D2D |
More data for this
Ligand-Target Pair | |
Alpha-2C adrenergic receptor
(Homo sapiens (Human)) | BDBM50203563
(6,7-dimethoxy-2-((7-methoxy-2-(2-(trifluoromethyl)...)Show SMILES COc1cc2CCN(Cc3ccc(OC)c4oc(cc34)-c3ccccc3C(F)(F)F)Cc2cc1OC Show InChI InChI=1S/C28H26F3NO4/c1-33-23-9-8-18(15-32-11-10-17-12-25(34-2)26(35-3)13-19(17)16-32)21-14-24(36-27(21)23)20-6-4-5-7-22(20)28(29,30)31/h4-9,12-14H,10-11,15-16H2,1-3H3 | PDB
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| 18 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Kyowa Hakko Kogyo Co. Ltd.
Curated by ChEMBL
| Assay Description
Displacement of [3H]MK912 from adrenergic Alpha-2C receptor in HepG2 cells |
Bioorg Med Chem Lett 17: 1616-21 (2007)
Article DOI: 10.1016/j.bmcl.2006.12.094
BindingDB Entry DOI: 10.7270/Q2TD9Z5F |
More data for this
Ligand-Target Pair | |
Alpha-2C adrenergic receptor
(Homo sapiens (Human)) | BDBM50203560
(8-((6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)...)Show SMILES COc1cc2CCN(Cc3cnc(N)n4nc(nc34)-c3ccco3)Cc2cc1OC Show InChI InChI=1S/C21H22N6O3/c1-28-17-8-13-5-6-26(11-14(13)9-18(17)29-2)12-15-10-23-21(22)27-20(15)24-19(25-27)16-4-3-7-30-16/h3-4,7-10H,5-6,11-12H2,1-2H3,(H2,22,23) | PDB
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| 19 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Kyowa Hakko Kogyo Co. Ltd.
Curated by ChEMBL
| Assay Description
Displacement of [3H]MK912 from adrenergic Alpha-2C receptor in HepG2 cells |
Bioorg Med Chem Lett 17: 1616-21 (2007)
Article DOI: 10.1016/j.bmcl.2006.12.094
BindingDB Entry DOI: 10.7270/Q2TD9Z5F |
More data for this
Ligand-Target Pair | |
Alpha-2C adrenergic receptor
(Homo sapiens (Human)) | BDBM50019848
(2-(2,3-dihydro-1,4-benzodioxin-2-yl)-4,5-dihydro-1...)Show InChI InChI=1S/C11H12N2O2/c1-2-4-9-8(3-1)14-7-10(15-9)11-12-5-6-13-11/h1-4,10H,5-7H2,(H,12,13) | PDB
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| 19 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Kyowa Hakko Kogyo Co. Ltd.
Curated by ChEMBL
| Assay Description
Displacement of [3H]MK912 from adrenergic Alpha-2C receptor in HepG2 cells |
Bioorg Med Chem Lett 17: 1616-21 (2007)
Article DOI: 10.1016/j.bmcl.2006.12.094
BindingDB Entry DOI: 10.7270/Q2TD9Z5F |
More data for this
Ligand-Target Pair | |
Alpha-2C adrenergic receptor
(Homo sapiens (Human)) | BDBM50203565
(6,7-dimethoxy-2-((7-methoxy-2-(3-methoxyphenyl)ben...)Show SMILES COc1cccc(c1)-c1cc2c(CN3CCc4cc(OC)c(OC)cc4C3)ccc(OC)c2o1 Show InChI InChI=1S/C28H29NO5/c1-30-22-7-5-6-19(12-22)25-15-23-20(8-9-24(31-2)28(23)34-25)16-29-11-10-18-13-26(32-3)27(33-4)14-21(18)17-29/h5-9,12-15H,10-11,16-17H2,1-4H3 | PDB
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| 19 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Kyowa Hakko Kogyo Co. Ltd.
Curated by ChEMBL
| Assay Description
Displacement of [3H]MK912 from adrenergic Alpha-2C receptor in HepG2 cells |
Bioorg Med Chem Lett 17: 1616-21 (2007)
Article DOI: 10.1016/j.bmcl.2006.12.094
BindingDB Entry DOI: 10.7270/Q2TD9Z5F |
More data for this
Ligand-Target Pair | |
Alpha-2C adrenergic receptor
(Homo sapiens (Human)) | BDBM50203555
(6,7-dimethoxy-2-((7-methoxy-2-phenylbenzofuran-4-y...)Show SMILES COc1cc2CCN(Cc3ccc(OC)c4oc(cc34)-c3ccccc3)Cc2cc1OC Show InChI InChI=1S/C27H27NO4/c1-29-23-10-9-20(22-15-24(32-27(22)23)18-7-5-4-6-8-18)16-28-12-11-19-13-25(30-2)26(31-3)14-21(19)17-28/h4-10,13-15H,11-12,16-17H2,1-3H3 | PDB
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| 20 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Kyowa Hakko Kogyo Co. Ltd.
Curated by ChEMBL
| Assay Description
Displacement of [3H]MK912 from adrenergic Alpha-2C receptor in HepG2 cells |
Bioorg Med Chem Lett 17: 1616-21 (2007)
Article DOI: 10.1016/j.bmcl.2006.12.094
BindingDB Entry DOI: 10.7270/Q2TD9Z5F |
More data for this
Ligand-Target Pair | |
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