Found 229 hits with Last Name = 'jarvie' and Initial = 'k' Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
D(1B) dopamine receptor
(RAT) | BDBM82247
(8-Chloro-3-methyl-5-phenyl-2,3,4,5-tetrahydro-1H-b...)Show InChI InChI=1S/C17H18ClNO/c1-19-8-7-13-9-16(18)17(20)10-14(13)15(11-19)12-5-3-2-4-6-12/h2-6,9-10,15,20H,7-8,11H2,1H3/t15-/m1/s1 | KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| Purchase
CHEMBL MCE PC cid PC sid UniChem
Similars
| Article PubMed
| 0.110 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Duke University
Curated by PDSP Ki Database
| |
Proc Natl Acad Sci U S A 88: 7491-5 (1991)
Article DOI: 10.1073/pnas.88.17.7491 BindingDB Entry DOI: 10.7270/Q2DB80B9 |
More data for this Ligand-Target Pair | |
D(1A) dopamine receptor
(Homo sapiens (Human)) | BDBM82247
(8-Chloro-3-methyl-5-phenyl-2,3,4,5-tetrahydro-1H-b...)Show InChI InChI=1S/C17H18ClNO/c1-19-8-7-13-9-16(18)17(20)10-14(13)15(11-19)12-5-3-2-4-6-12/h2-6,9-10,15,20H,7-8,11H2,1H3/t15-/m1/s1 | PDB
KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MCE PC cid PC sid UniChem
Similars
| Article PubMed
| 0.170 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Duke University
Curated by PDSP Ki Database
| |
Proc Natl Acad Sci U S A 88: 7491-5 (1991)
Article DOI: 10.1073/pnas.88.17.7491 BindingDB Entry DOI: 10.7270/Q2DB80B9 |
More data for this Ligand-Target Pair | |
D(1A) dopamine receptor
(Homo sapiens (Human)) | BDBM81490
(CAS_60197-32-2 | CIS PIFLUTIXOL | NSC_68714 | Pifl...)Show SMILES OCCC1CCN(CCC=C2c3ccc(F)cc3Sc3ccc(cc23)C(F)(F)F)CC1 |w:9.8| Show InChI InChI=1S/C24H25F4NOS/c25-18-4-5-20-19(2-1-10-29-11-7-16(8-12-29)9-13-30)21-14-17(24(26,27)28)3-6-22(21)31-23(20)15-18/h2-6,14-16,30H,1,7-13H2 | PDB
KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| 0.650 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Duke University
Curated by PDSP Ki Database
| |
Proc Natl Acad Sci U S A 88: 7491-5 (1991)
Article DOI: 10.1073/pnas.88.17.7491 BindingDB Entry DOI: 10.7270/Q2DB80B9 |
More data for this Ligand-Target Pair | |
D(1A) dopamine receptor
(Homo sapiens (Human)) | BDBM50008735
((+)-3-(tert-butyl)-(3S,4aS,13bS)-2,3,4,4a,8,9,13b,...)Show SMILES CC(C)(C)[C@]1(O)CCN2C[C@H]3c4ccccc4CCc4cccc([C@@H]2C1)c34 Show InChI InChI=1S/C25H31NO/c1-24(2,3)25(27)13-14-26-16-21-19-9-5-4-7-17(19)11-12-18-8-6-10-20(23(18)21)22(26)15-25/h4-10,21-22,27H,11-16H2,1-3H3/t21-,22-,25-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 1 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Duke University
Curated by PDSP Ki Database
| |
Proc Natl Acad Sci U S A 88: 7491-5 (1991)
Article DOI: 10.1073/pnas.88.17.7491 BindingDB Entry DOI: 10.7270/Q2DB80B9 |
More data for this Ligand-Target Pair | |
D(4) dopamine receptor
(Homo sapiens (Human)) | BDBM50152303
(CHEMBL361035 | N-((S)-1-Benzyl-pyrrolidin-3-yl)-3-...)Show SMILES O=C(N[C@H]1CCN(Cc2ccccc2)C1)c1cccc(c1)-c1cccs1 Show InChI InChI=1S/C22H22N2OS/c25-22(19-9-4-8-18(14-19)21-10-5-13-26-21)23-20-11-12-24(16-20)15-17-6-2-1-3-7-17/h1-10,13-14,20H,11-12,15-16H2,(H,23,25)/t20-/m0/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 1.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
NPS Pharmaceuticals
Curated by ChEMBL
| Assay Description Displacement of [3H]spiperone from cloned human dopamine D4.2 receptor in HEK298 cells |
Bioorg Med Chem Lett 15: 5253-6 (2005)
Article DOI: 10.1016/j.bmcl.2005.08.051 BindingDB Entry DOI: 10.7270/Q26D5TSR |
More data for this Ligand-Target Pair | |
D(4) dopamine receptor
(Homo sapiens (Human)) | BDBM50152303
(CHEMBL361035 | N-((S)-1-Benzyl-pyrrolidin-3-yl)-3-...)Show SMILES O=C(N[C@H]1CCN(Cc2ccccc2)C1)c1cccc(c1)-c1cccs1 Show InChI InChI=1S/C22H22N2OS/c25-22(19-9-4-8-18(14-19)21-10-5-13-26-21)23-20-11-12-24(16-20)15-17-6-2-1-3-7-17/h1-10,13-14,20H,11-12,15-16H2,(H,23,25)/t20-/m0/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 1.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
NPS Pharmaceuticals Inc.
Curated by ChEMBL
| Assay Description Ability to displace [3H]-spiperone from human Dopamine receptor D4.2 stably transfected in human embryonic kidney 298 cells |
Bioorg Med Chem Lett 14: 4847-50 (2004)
Article DOI: 10.1016/j.bmcl.2004.07.045 BindingDB Entry DOI: 10.7270/Q20C4V7D |
More data for this Ligand-Target Pair | |
5-hydroxytryptamine receptor 2A
(Homo sapiens (Human)) | BDBM50152314
((S)-N-(1-benzylpyrrolidin-3-yl)-4-(thiophen-2-yl)b...)Show SMILES O=C(N[C@H]1CCN(Cc2ccccc2)C1)c1ccc(cc1)-c1cccs1 Show InChI InChI=1S/C22H22N2OS/c25-22(19-10-8-18(9-11-19)21-7-4-14-26-21)23-20-12-13-24(16-20)15-17-5-2-1-3-6-17/h1-11,14,20H,12-13,15-16H2,(H,23,25)/t20-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 1.80 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
NPS Pharmaceuticals
Curated by ChEMBL
| Assay Description Displacement of [3H]ketanserin from cloned human 5HT2A receptor in HEK298 cells |
Bioorg Med Chem Lett 15: 5253-6 (2005)
Article DOI: 10.1016/j.bmcl.2005.08.051 BindingDB Entry DOI: 10.7270/Q26D5TSR |
More data for this Ligand-Target Pair | |
D(4) dopamine receptor
(Homo sapiens (Human)) | BDBM50152298
(CHEMBL426062 | N-((S)-1-Benzyl-pyrrolidin-3-yl)-3-...)Show SMILES O=C(N[C@H]1CCN(Cc2ccccc2)C1)c1cccc(c1)-c1ccsc1 Show InChI InChI=1S/C22H22N2OS/c25-22(19-8-4-7-18(13-19)20-10-12-26-16-20)23-21-9-11-24(15-21)14-17-5-2-1-3-6-17/h1-8,10,12-13,16,21H,9,11,14-15H2,(H,23,25)/t21-/m0/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 2 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
NPS Pharmaceuticals Inc.
Curated by ChEMBL
| Assay Description Ability to displace [3H]-spiperone from human Dopamine receptor D4.2 stably transfected in human embryonic kidney 298 cells |
Bioorg Med Chem Lett 14: 4847-50 (2004)
Article DOI: 10.1016/j.bmcl.2004.07.045 BindingDB Entry DOI: 10.7270/Q20C4V7D |
More data for this Ligand-Target Pair | |
D(4) dopamine receptor
(Homo sapiens (Human)) | BDBM50152296
(CHEMBL364782 | N-((S)-1-Benzyl-pyrrolidin-3-yl)-4-...)Show SMILES O=C(N[C@H]1CCN(Cc2ccccc2)C1)c1ccc(cc1)-c1ccsc1 Show InChI InChI=1S/C22H22N2OS/c25-22(19-8-6-18(7-9-19)20-11-13-26-16-20)23-21-10-12-24(15-21)14-17-4-2-1-3-5-17/h1-9,11,13,16,21H,10,12,14-15H2,(H,23,25)/t21-/m0/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 2 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
NPS Pharmaceuticals Inc.
Curated by ChEMBL
| Assay Description Ability to displace [3H]-spiperone from human Dopamine receptor D4.2 stably transfected in human embryonic kidney 298 cells |
Bioorg Med Chem Lett 14: 4847-50 (2004)
Article DOI: 10.1016/j.bmcl.2004.07.045 BindingDB Entry DOI: 10.7270/Q20C4V7D |
More data for this Ligand-Target Pair | |
D(4) dopamine receptor
(Homo sapiens (Human)) | BDBM50152306
(CHEMBL187122 | N-(1-Benzyl-pyrrolidin-3-yl)-4-thio...)Show InChI InChI=1S/C22H22N2OS/c25-22(19-8-6-18(7-9-19)20-11-13-26-16-20)23-21-10-12-24(15-21)14-17-4-2-1-3-5-17/h1-9,11,13,16,21H,10,12,14-15H2,(H,23,25) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 2 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
NPS Pharmaceuticals Inc.
Curated by ChEMBL
| Assay Description Ability to displace [3H]-spiperone from human Dopamine receptor D4.2 stably transfected in human embryonic kidney 298 cells |
Bioorg Med Chem Lett 14: 4847-50 (2004)
Article DOI: 10.1016/j.bmcl.2004.07.045 BindingDB Entry DOI: 10.7270/Q20C4V7D |
More data for this Ligand-Target Pair | |
D(1B) dopamine receptor
(RAT) | BDBM81490
(CAS_60197-32-2 | CIS PIFLUTIXOL | NSC_68714 | Pifl...)Show SMILES OCCC1CCN(CCC=C2c3ccc(F)cc3Sc3ccc(cc23)C(F)(F)F)CC1 |w:9.8| Show InChI InChI=1S/C24H25F4NOS/c25-18-4-5-20-19(2-1-10-29-11-7-16(8-12-29)9-13-30)21-14-17(24(26,27)28)3-6-22(21)31-23(20)15-18/h2-6,14-16,30H,1,7-13H2 | KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| 2 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Duke University
Curated by PDSP Ki Database
| |
Proc Natl Acad Sci U S A 88: 7491-5 (1991)
Article DOI: 10.1073/pnas.88.17.7491 BindingDB Entry DOI: 10.7270/Q2DB80B9 |
More data for this Ligand-Target Pair | |
D(4) dopamine receptor
(Homo sapiens (Human)) | BDBM50152314
((S)-N-(1-benzylpyrrolidin-3-yl)-4-(thiophen-2-yl)b...)Show SMILES O=C(N[C@H]1CCN(Cc2ccccc2)C1)c1ccc(cc1)-c1cccs1 Show InChI InChI=1S/C22H22N2OS/c25-22(19-10-8-18(9-11-19)21-7-4-14-26-21)23-20-12-13-24(16-20)15-17-5-2-1-3-6-17/h1-11,14,20H,12-13,15-16H2,(H,23,25)/t20-/m0/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
NPS Pharmaceuticals Inc.
Curated by ChEMBL
| Assay Description Ability to displace [3H]-spiperone from human Dopamine receptor D4.2 stably transfected in human embryonic kidney 298 cells |
Bioorg Med Chem Lett 14: 4847-50 (2004)
Article DOI: 10.1016/j.bmcl.2004.07.045 BindingDB Entry DOI: 10.7270/Q20C4V7D |
More data for this Ligand-Target Pair | |
D(4) dopamine receptor
(Homo sapiens (Human)) | BDBM50152297
(CHEMBL187236 | N-(1-Benzyl-pyrrolidin-3-yl)-4-thio...)Show InChI InChI=1S/C22H22N2OS/c25-22(19-10-8-18(9-11-19)21-7-4-14-26-21)23-20-12-13-24(16-20)15-17-5-2-1-3-6-17/h1-11,14,20H,12-13,15-16H2,(H,23,25) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
NPS Pharmaceuticals Inc.
Curated by ChEMBL
| Assay Description Ability to displace [3H]-spiperone from human Dopamine receptor D4.2 stably transfected in human embryonic kidney 298 cells |
Bioorg Med Chem Lett 14: 4847-50 (2004)
Article DOI: 10.1016/j.bmcl.2004.07.045 BindingDB Entry DOI: 10.7270/Q20C4V7D |
More data for this Ligand-Target Pair | |
D(4) dopamine receptor
(Homo sapiens (Human)) | BDBM50152305
(Biphenyl-4-carboxylic acid (1-benzyl-pyrrolidin-3-...)Show SMILES O=C(NC1CCN(Cc2ccccc2)C1)c1ccc(cc1)-c1ccccc1 Show InChI InChI=1S/C24H24N2O/c27-24(22-13-11-21(12-14-22)20-9-5-2-6-10-20)25-23-15-16-26(18-23)17-19-7-3-1-4-8-19/h1-14,23H,15-18H2,(H,25,27) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
NPS Pharmaceuticals Inc.
Curated by ChEMBL
| Assay Description Ability to displace [3H]-spiperone from human Dopamine receptor D4.2 stably transfected in human embryonic kidney 298 cells |
Bioorg Med Chem Lett 14: 4847-50 (2004)
Article DOI: 10.1016/j.bmcl.2004.07.045 BindingDB Entry DOI: 10.7270/Q20C4V7D |
More data for this Ligand-Target Pair | |
D(4) dopamine receptor
(Homo sapiens (Human)) | BDBM50152314
((S)-N-(1-benzylpyrrolidin-3-yl)-4-(thiophen-2-yl)b...)Show SMILES O=C(N[C@H]1CCN(Cc2ccccc2)C1)c1ccc(cc1)-c1cccs1 Show InChI InChI=1S/C22H22N2OS/c25-22(19-10-8-18(9-11-19)21-7-4-14-26-21)23-20-12-13-24(16-20)15-17-5-2-1-3-6-17/h1-11,14,20H,12-13,15-16H2,(H,23,25)/t20-/m0/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
NPS Pharmaceuticals
Curated by ChEMBL
| Assay Description Displacement of [3H]spiperone from cloned human dopamine D4.2 receptor in HEK298 cells |
Bioorg Med Chem Lett 15: 5253-6 (2005)
Article DOI: 10.1016/j.bmcl.2005.08.051 BindingDB Entry DOI: 10.7270/Q26D5TSR |
More data for this Ligand-Target Pair | |
D(4) dopamine receptor
(Homo sapiens (Human)) | BDBM50152302
(CHEMBL187113 | N-((R)-1-Benzyl-pyrrolidin-3-yl)-3-...)Show SMILES O=C(N[C@@H]1CCN(Cc2ccccc2)C1)c1cccc(c1)-c1ccsc1 Show InChI InChI=1S/C22H22N2OS/c25-22(19-8-4-7-18(13-19)20-10-12-26-16-20)23-21-9-11-24(15-21)14-17-5-2-1-3-6-17/h1-8,10,12-13,16,21H,9,11,14-15H2,(H,23,25)/t21-/m1/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 3.40 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
NPS Pharmaceuticals Inc.
Curated by ChEMBL
| Assay Description Ability to displace [3H]-spiperone from human Dopamine receptor D4.2 stably transfected in human embryonic kidney 298 cells |
Bioorg Med Chem Lett 14: 4847-50 (2004)
Article DOI: 10.1016/j.bmcl.2004.07.045 BindingDB Entry DOI: 10.7270/Q20C4V7D |
More data for this Ligand-Target Pair | |
D(4) dopamine receptor
(Homo sapiens (Human)) | BDBM50174001
(CHEMBL381019 | N-[(S)-1-(4-Methyl-benzyl)-pyrrolid...)Show SMILES Cc1ccc(CN2CC[C@@H](C2)NC(=O)c2cccc(c2)-c2cccs2)cc1 Show InChI InChI=1S/C23H24N2OS/c1-17-7-9-18(10-8-17)15-25-12-11-21(16-25)24-23(26)20-5-2-4-19(14-20)22-6-3-13-27-22/h2-10,13-14,21H,11-12,15-16H2,1H3,(H,24,26)/t21-/m0/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
NPS Pharmaceuticals
Curated by ChEMBL
| Assay Description Displacement of [3H]spiperone from cloned human dopamine D4.2 receptor in HEK298 cells |
Bioorg Med Chem Lett 15: 5253-6 (2005)
Article DOI: 10.1016/j.bmcl.2005.08.051 BindingDB Entry DOI: 10.7270/Q26D5TSR |
More data for this Ligand-Target Pair | |
D(1A) dopamine receptor
(Homo sapiens (Human)) | BDBM50026957
((cis) 2-{4-[3-(2-Trifluoromethyl-thioxanthen-9-yli...)Show SMILES OCCN1CCN(CC\C=C2/c3ccccc3Sc3ccc(cc23)C(F)(F)F)CC1 Show InChI InChI=1S/C23H25F3N2OS/c24-23(25,26)17-7-8-22-20(16-17)18(19-4-1-2-6-21(19)30-22)5-3-9-27-10-12-28(13-11-27)14-15-29/h1-2,4-8,16,29H,3,9-15H2/b18-5+ | PDB
KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
MCE PC cid PC sid UniChem
Similars
| Article PubMed
| 4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Duke University
Curated by PDSP Ki Database
| |
Proc Natl Acad Sci U S A 88: 7491-5 (1991)
Article DOI: 10.1073/pnas.88.17.7491 BindingDB Entry DOI: 10.7270/Q2DB80B9 |
More data for this Ligand-Target Pair | |
D(4) dopamine receptor
(Homo sapiens (Human)) | BDBM50152309
(Biphenyl-3-carboxylic acid (1-benzyl-pyrrolidin-3-...)Show SMILES O=C(NC1CCN(Cc2ccccc2)C1)c1cccc(c1)-c1ccccc1 Show InChI InChI=1S/C24H24N2O/c27-24(22-13-7-12-21(16-22)20-10-5-2-6-11-20)25-23-14-15-26(18-23)17-19-8-3-1-4-9-19/h1-13,16,23H,14-15,17-18H2,(H,25,27) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
NPS Pharmaceuticals Inc.
Curated by ChEMBL
| Assay Description Ability to displace [3H]-spiperone from human Dopamine receptor D4.2 stably transfected in human embryonic kidney 298 cells |
Bioorg Med Chem Lett 14: 4847-50 (2004)
Article DOI: 10.1016/j.bmcl.2004.07.045 BindingDB Entry DOI: 10.7270/Q20C4V7D |
More data for this Ligand-Target Pair | |
D(4) dopamine receptor
(Homo sapiens (Human)) | BDBM50152311
(4''-Chloro-biphenyl-4-carboxylic acid (1-benzyl-py...)Show SMILES Clc1ccc(cc1)-c1ccc(cc1)C(=O)NC1CCN(Cc2ccccc2)C1 Show InChI InChI=1S/C24H23ClN2O/c25-22-12-10-20(11-13-22)19-6-8-21(9-7-19)24(28)26-23-14-15-27(17-23)16-18-4-2-1-3-5-18/h1-13,23H,14-17H2,(H,26,28) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
NPS Pharmaceuticals Inc.
Curated by ChEMBL
| Assay Description Ability to displace [3H]-spiperone from human Dopamine receptor D4.2 stably transfected in human embryonic kidney 298 cells |
Bioorg Med Chem Lett 14: 4847-50 (2004)
Article DOI: 10.1016/j.bmcl.2004.07.045 BindingDB Entry DOI: 10.7270/Q20C4V7D |
More data for this Ligand-Target Pair | |
D(4) dopamine receptor
(Homo sapiens (Human)) | BDBM50174000
((S)-N-(1-(4-fluorobenzyl)pyrrolidin-3-yl)-4-(thiop...)Show SMILES Fc1ccc(CN2CC[C@@H](C2)NC(=O)c2ccc(cc2)-c2cccs2)cc1 Show InChI InChI=1S/C22H21FN2OS/c23-19-9-3-16(4-10-19)14-25-12-11-20(15-25)24-22(26)18-7-5-17(6-8-18)21-2-1-13-27-21/h1-10,13,20H,11-12,14-15H2,(H,24,26)/t20-/m0/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
NPS Pharmaceuticals
Curated by ChEMBL
| Assay Description Displacement of [3H]spiperone from cloned human dopamine D4.2 receptor in HEK298 cells |
Bioorg Med Chem Lett 15: 5253-6 (2005)
Article DOI: 10.1016/j.bmcl.2005.08.051 BindingDB Entry DOI: 10.7270/Q26D5TSR |
More data for this Ligand-Target Pair | |
D(1B) dopamine receptor
(RAT) | BDBM50008735
((+)-3-(tert-butyl)-(3S,4aS,13bS)-2,3,4,4a,8,9,13b,...)Show SMILES CC(C)(C)[C@]1(O)CCN2C[C@H]3c4ccccc4CCc4cccc([C@@H]2C1)c34 Show InChI InChI=1S/C25H31NO/c1-24(2,3)25(27)13-14-26-16-21-19-9-5-4-7-17(19)11-12-18-8-6-10-20(23(18)21)22(26)15-25/h4-10,21-22,27H,11-16H2,1-3H3/t21-,22-,25-/m0/s1 | KEGG
UniProtKB/SwissProt
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| Article PubMed
| 6 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Duke University
Curated by PDSP Ki Database
| |
Proc Natl Acad Sci U S A 88: 7491-5 (1991)
Article DOI: 10.1073/pnas.88.17.7491 BindingDB Entry DOI: 10.7270/Q2DB80B9 |
More data for this Ligand-Target Pair | |
D(4) dopamine receptor
(Homo sapiens (Human)) | BDBM50174006
((S)-N-(1-(benzo[d][1,3]dioxol-5-ylmethyl)pyrrolidi...)Show SMILES O=C(N[C@H]1CCN(Cc2ccc3OCOc3c2)C1)c1ccc(cc1)-c1cccs1 Show InChI InChI=1S/C23H22N2O3S/c26-23(18-6-4-17(5-7-18)22-2-1-11-29-22)24-19-9-10-25(14-19)13-16-3-8-20-21(12-16)28-15-27-20/h1-8,11-12,19H,9-10,13-15H2,(H,24,26)/t19-/m0/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 7 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
NPS Pharmaceuticals
Curated by ChEMBL
| Assay Description Displacement of [3H]spiperone from cloned human dopamine D4.2 receptor in HEK298 cells |
Bioorg Med Chem Lett 15: 5253-6 (2005)
Article DOI: 10.1016/j.bmcl.2005.08.051 BindingDB Entry DOI: 10.7270/Q26D5TSR |
More data for this Ligand-Target Pair | |
D(1B) dopamine receptor
(RAT) | BDBM50026957
((cis) 2-{4-[3-(2-Trifluoromethyl-thioxanthen-9-yli...)Show SMILES OCCN1CCN(CC\C=C2/c3ccccc3Sc3ccc(cc23)C(F)(F)F)CC1 Show InChI InChI=1S/C23H25F3N2OS/c24-23(25,26)17-7-8-22-20(16-17)18(19-4-1-2-6-21(19)30-22)5-3-9-27-10-12-28(13-11-27)14-15-29/h1-2,4-8,16,29H,3,9-15H2/b18-5+ | KEGG
UniProtKB/SwissProt
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| 7 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Duke University
Curated by PDSP Ki Database
| |
Proc Natl Acad Sci U S A 88: 7491-5 (1991)
Article DOI: 10.1073/pnas.88.17.7491 BindingDB Entry DOI: 10.7270/Q2DB80B9 |
More data for this Ligand-Target Pair | |
D(4) dopamine receptor
(Homo sapiens (Human)) | BDBM50152310
(4''-Fluoro-biphenyl-4-carboxylic acid (1-benzyl-py...)Show SMILES Fc1ccc(cc1)-c1ccc(cc1)C(=O)NC1CCN(Cc2ccccc2)C1 Show InChI InChI=1S/C24H23FN2O/c25-22-12-10-20(11-13-22)19-6-8-21(9-7-19)24(28)26-23-14-15-27(17-23)16-18-4-2-1-3-5-18/h1-13,23H,14-17H2,(H,26,28) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 8 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
NPS Pharmaceuticals Inc.
Curated by ChEMBL
| Assay Description Ability to displace [3H]-spiperone from human Dopamine receptor D4.2 stably transfected in human embryonic kidney 298 cells |
Bioorg Med Chem Lett 14: 4847-50 (2004)
Article DOI: 10.1016/j.bmcl.2004.07.045 BindingDB Entry DOI: 10.7270/Q20C4V7D |
More data for this Ligand-Target Pair | |
D(1B) dopamine receptor
(RAT) | BDBM82247
(8-Chloro-3-methyl-5-phenyl-2,3,4,5-tetrahydro-1H-b...)Show InChI InChI=1S/C17H18ClNO/c1-19-8-7-13-9-16(18)17(20)10-14(13)15(11-19)12-5-3-2-4-6-12/h2-6,9-10,15,20H,7-8,11H2,1H3/t15-/m1/s1 | KEGG
UniProtKB/SwissProt
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CHEMBL MCE PC cid PC sid UniChem
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| Article PubMed
| 10 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Duke University
Curated by PDSP Ki Database
| |
Proc Natl Acad Sci U S A 88: 7491-5 (1991)
Article DOI: 10.1073/pnas.88.17.7491 BindingDB Entry DOI: 10.7270/Q2DB80B9 |
More data for this Ligand-Target Pair | |
D(1B) dopamine receptor
(RAT) | BDBM60917
(9-chloranyl-5-(4-hydroxyphenyl)-2,3,4,5-tetrahydro...)Show InChI InChI=1S/C16H16ClNO3/c17-15-11-5-6-18-8-13(9-1-3-10(19)4-2-9)12(11)7-14(20)16(15)21/h1-4,7,13,18-21H,5-6,8H2 | KEGG
UniProtKB/SwissProt
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| Article PubMed
| 11 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Duke University
Curated by PDSP Ki Database
| |
Proc Natl Acad Sci U S A 88: 7491-5 (1991)
Article DOI: 10.1073/pnas.88.17.7491 BindingDB Entry DOI: 10.7270/Q2DB80B9 |
More data for this Ligand-Target Pair | |
D(4) dopamine receptor
(Homo sapiens (Human)) | BDBM50174003
((S)-N-(1-(3-methoxybenzyl)pyrrolidin-3-yl)-4-(thio...)Show SMILES COc1cccc(CN2CC[C@@H](C2)NC(=O)c2ccc(cc2)-c2cccs2)c1 Show InChI InChI=1S/C23H24N2O2S/c1-27-21-5-2-4-17(14-21)15-25-12-11-20(16-25)24-23(26)19-9-7-18(8-10-19)22-6-3-13-28-22/h2-10,13-14,20H,11-12,15-16H2,1H3,(H,24,26)/t20-/m0/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 14 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
NPS Pharmaceuticals
Curated by ChEMBL
| Assay Description Displacement of [3H]spiperone from cloned human dopamine D4.2 receptor in HEK298 cells |
Bioorg Med Chem Lett 15: 5253-6 (2005)
Article DOI: 10.1016/j.bmcl.2005.08.051 BindingDB Entry DOI: 10.7270/Q26D5TSR |
More data for this Ligand-Target Pair | |
D(4) dopamine receptor
(Homo sapiens (Human)) | BDBM50174011
((S)-N-(1-(4-(trifluoromethyl)benzyl)pyrrolidin-3-y...)Show SMILES FC(F)(F)c1ccc(CN2CC[C@@H](C2)NC(=O)c2ccc(cc2)-c2cccs2)cc1 Show InChI InChI=1S/C23H21F3N2OS/c24-23(25,26)19-9-3-16(4-10-19)14-28-12-11-20(15-28)27-22(29)18-7-5-17(6-8-18)21-2-1-13-30-21/h1-10,13,20H,11-12,14-15H2,(H,27,29)/t20-/m0/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 14 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
NPS Pharmaceuticals
Curated by ChEMBL
| Assay Description Displacement of [3H]spiperone from cloned human dopamine D4.2 receptor in HEK298 cells |
Bioorg Med Chem Lett 15: 5253-6 (2005)
Article DOI: 10.1016/j.bmcl.2005.08.051 BindingDB Entry DOI: 10.7270/Q26D5TSR |
More data for this Ligand-Target Pair | |
D(4) dopamine receptor
(Homo sapiens (Human)) | BDBM50174008
((S)-N-(1-(3,4-difluorobenzyl)pyrrolidin-3-yl)-4-(t...)Show SMILES Fc1ccc(CN2CC[C@@H](C2)NC(=O)c2ccc(cc2)-c2cccs2)cc1F Show InChI InChI=1S/C22H20F2N2OS/c23-19-8-3-15(12-20(19)24)13-26-10-9-18(14-26)25-22(27)17-6-4-16(5-7-17)21-2-1-11-28-21/h1-8,11-12,18H,9-10,13-14H2,(H,25,27)/t18-/m0/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 14 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
NPS Pharmaceuticals
Curated by ChEMBL
| Assay Description Displacement of [3H]spiperone from cloned human dopamine D4.2 receptor in HEK298 cells |
Bioorg Med Chem Lett 15: 5253-6 (2005)
Article DOI: 10.1016/j.bmcl.2005.08.051 BindingDB Entry DOI: 10.7270/Q26D5TSR |
More data for this Ligand-Target Pair | |
5-hydroxytryptamine receptor 2A
(Homo sapiens (Human)) | BDBM50174000
((S)-N-(1-(4-fluorobenzyl)pyrrolidin-3-yl)-4-(thiop...)Show SMILES Fc1ccc(CN2CC[C@@H](C2)NC(=O)c2ccc(cc2)-c2cccs2)cc1 Show InChI InChI=1S/C22H21FN2OS/c23-19-9-3-16(4-10-19)14-25-12-11-20(15-25)24-22(26)18-7-5-17(6-8-18)21-2-1-13-27-21/h1-10,13,20H,11-12,14-15H2,(H,24,26)/t20-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 14 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
NPS Pharmaceuticals
Curated by ChEMBL
| Assay Description Displacement of [3H]ketanserin from cloned human 5HT2A receptor in HEK298 cells |
Bioorg Med Chem Lett 15: 5253-6 (2005)
Article DOI: 10.1016/j.bmcl.2005.08.051 BindingDB Entry DOI: 10.7270/Q26D5TSR |
More data for this Ligand-Target Pair | |
D(1A) dopamine receptor
(Homo sapiens (Human)) | BDBM82247
(8-Chloro-3-methyl-5-phenyl-2,3,4,5-tetrahydro-1H-b...)Show InChI InChI=1S/C17H18ClNO/c1-19-8-7-13-9-16(18)17(20)10-14(13)15(11-19)12-5-3-2-4-6-12/h2-6,9-10,15,20H,7-8,11H2,1H3/t15-/m1/s1 | PDB
KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MCE PC cid PC sid UniChem
Similars
| Article PubMed
| 15 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Duke University
Curated by PDSP Ki Database
| |
Proc Natl Acad Sci U S A 88: 7491-5 (1991)
Article DOI: 10.1073/pnas.88.17.7491 BindingDB Entry DOI: 10.7270/Q2DB80B9 |
More data for this Ligand-Target Pair | |
D(4) dopamine receptor
(Homo sapiens (Human)) | BDBM50174010
((S)-N-(1-(3,4-dichlorobenzyl)pyrrolidin-3-yl)-4-(t...)Show SMILES Clc1ccc(CN2CC[C@@H](C2)NC(=O)c2ccc(cc2)-c2cccs2)cc1Cl Show InChI InChI=1S/C22H20Cl2N2OS/c23-19-8-3-15(12-20(19)24)13-26-10-9-18(14-26)25-22(27)17-6-4-16(5-7-17)21-2-1-11-28-21/h1-8,11-12,18H,9-10,13-14H2,(H,25,27)/t18-/m0/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 15 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
NPS Pharmaceuticals
Curated by ChEMBL
| Assay Description Displacement of [3H]spiperone from cloned human dopamine D4.2 receptor in HEK298 cells |
Bioorg Med Chem Lett 15: 5253-6 (2005)
Article DOI: 10.1016/j.bmcl.2005.08.051 BindingDB Entry DOI: 10.7270/Q26D5TSR |
More data for this Ligand-Target Pair | |
5-hydroxytryptamine receptor 2A
(Homo sapiens (Human)) | BDBM50174008
((S)-N-(1-(3,4-difluorobenzyl)pyrrolidin-3-yl)-4-(t...)Show SMILES Fc1ccc(CN2CC[C@@H](C2)NC(=O)c2ccc(cc2)-c2cccs2)cc1F Show InChI InChI=1S/C22H20F2N2OS/c23-19-8-3-15(12-20(19)24)13-26-10-9-18(14-26)25-22(27)17-6-4-16(5-7-17)21-2-1-11-28-21/h1-8,11-12,18H,9-10,13-14H2,(H,25,27)/t18-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 16 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
NPS Pharmaceuticals
Curated by ChEMBL
| Assay Description Displacement of [3H]ketanserin from cloned human 5HT2A receptor in HEK298 cells |
Bioorg Med Chem Lett 15: 5253-6 (2005)
Article DOI: 10.1016/j.bmcl.2005.08.051 BindingDB Entry DOI: 10.7270/Q26D5TSR |
More data for this Ligand-Target Pair | |
D(4) dopamine receptor
(Homo sapiens (Human)) | BDBM50174004
(CHEMBL197381 | N-((S)-1-(4-chlorobenzyl)pyrrolidin...)Show SMILES Clc1ccc(CN2CC[C@@H](C2)NC(=O)c2cccc(c2)-c2cccs2)cc1 Show InChI InChI=1S/C22H21ClN2OS/c23-19-8-6-16(7-9-19)14-25-11-10-20(15-25)24-22(26)18-4-1-3-17(13-18)21-5-2-12-27-21/h1-9,12-13,20H,10-11,14-15H2,(H,24,26)/t20-/m0/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 16 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
NPS Pharmaceuticals
Curated by ChEMBL
| Assay Description Displacement of [3H]spiperone from cloned human dopamine D4.2 receptor in HEK298 cells |
Bioorg Med Chem Lett 15: 5253-6 (2005)
Article DOI: 10.1016/j.bmcl.2005.08.051 BindingDB Entry DOI: 10.7270/Q26D5TSR |
More data for this Ligand-Target Pair | |
D(4) dopamine receptor
(Homo sapiens (Human)) | BDBM50152308
(4''-Methylsulfanyl-biphenyl-4-carboxylic acid (1-b...)Show SMILES CSc1ccc(cc1)-c1ccc(cc1)C(=O)NC1CCN(Cc2ccccc2)C1 Show InChI InChI=1S/C25H26N2OS/c1-29-24-13-11-21(12-14-24)20-7-9-22(10-8-20)25(28)26-23-15-16-27(18-23)17-19-5-3-2-4-6-19/h2-14,23H,15-18H2,1H3,(H,26,28) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 17 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
NPS Pharmaceuticals Inc.
Curated by ChEMBL
| Assay Description Ability to displace [3H]-spiperone from human Dopamine receptor D4.2 stably transfected in human embryonic kidney 298 cells |
Bioorg Med Chem Lett 14: 4847-50 (2004)
Article DOI: 10.1016/j.bmcl.2004.07.045 BindingDB Entry DOI: 10.7270/Q20C4V7D |
More data for this Ligand-Target Pair | |
D(4) dopamine receptor
(Homo sapiens (Human)) | BDBM50152312
(3''-Fluoro-biphenyl-4-carboxylic acid (1-benzyl-py...)Show SMILES Fc1cccc(c1)-c1ccc(cc1)C(=O)NC1CCN(Cc2ccccc2)C1 Show InChI InChI=1S/C24H23FN2O/c25-22-8-4-7-21(15-22)19-9-11-20(12-10-19)24(28)26-23-13-14-27(17-23)16-18-5-2-1-3-6-18/h1-12,15,23H,13-14,16-17H2,(H,26,28) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 17 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
NPS Pharmaceuticals Inc.
Curated by ChEMBL
| Assay Description Ability to displace [3H]-spiperone from human Dopamine receptor D4.2 stably transfected in human embryonic kidney 298 cells |
Bioorg Med Chem Lett 14: 4847-50 (2004)
Article DOI: 10.1016/j.bmcl.2004.07.045 BindingDB Entry DOI: 10.7270/Q20C4V7D |
More data for this Ligand-Target Pair | |
D(1A) dopamine receptor
(Homo sapiens (Human)) | BDBM60917
(9-chloranyl-5-(4-hydroxyphenyl)-2,3,4,5-tetrahydro...)Show InChI InChI=1S/C16H16ClNO3/c17-15-11-5-6-18-8-13(9-1-3-10(19)4-2-9)12(11)7-14(20)16(15)21/h1-4,7,13,18-21H,5-6,8H2 | PDB
KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
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| 17 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Duke University
Curated by PDSP Ki Database
| |
Proc Natl Acad Sci U S A 88: 7491-5 (1991)
Article DOI: 10.1073/pnas.88.17.7491 BindingDB Entry DOI: 10.7270/Q2DB80B9 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
D(4) dopamine receptor
(Homo sapiens (Human)) | BDBM50152313
(4''-Trifluoromethyl-biphenyl-4-carboxylic acid (1-...)Show SMILES FC(F)(F)c1ccc(cc1)-c1ccc(cc1)C(=O)NC1CCN(Cc2ccccc2)C1 Show InChI InChI=1S/C25H23F3N2O/c26-25(27,28)22-12-10-20(11-13-22)19-6-8-21(9-7-19)24(31)29-23-14-15-30(17-23)16-18-4-2-1-3-5-18/h1-13,23H,14-17H2,(H,29,31) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 17 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
NPS Pharmaceuticals Inc.
Curated by ChEMBL
| Assay Description Ability to displace [3H]-spiperone from human Dopamine receptor D4.2 stably transfected in human embryonic kidney 298 cells |
Bioorg Med Chem Lett 14: 4847-50 (2004)
Article DOI: 10.1016/j.bmcl.2004.07.045 BindingDB Entry DOI: 10.7270/Q20C4V7D |
More data for this Ligand-Target Pair | |
Metabotropic glutamate receptor 5
(Homo sapiens (Human)) | BDBM50395922
(CHEMBL2164552)Show InChI InChI=1S/C15H6FN5O/c16-12-4-10(7-18)3-11(5-12)15-20-14(21-22-15)13-2-1-9(6-17)8-19-13/h1-5,8H | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 17.9 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description Displacement of [3H]AZD9272 from human mGluR5 expressed in HEK293 cell membranes expressing GLAST after 1 hr by scintillation counter |
Bioorg Med Chem Lett 22: 6974-9 (2012)
Article DOI: 10.1016/j.bmcl.2012.08.100 BindingDB Entry DOI: 10.7270/Q2BP03WH |
More data for this Ligand-Target Pair | |
D(4) dopamine receptor
(Homo sapiens (Human)) | BDBM50152301
(CHEMBL366304 | N-((R)-1-Benzyl-pyrrolidin-3-yl)-4-...)Show SMILES O=C(N[C@@H]1CCN(Cc2ccccc2)C1)c1ccc(cc1)-c1ccsc1 Show InChI InChI=1S/C22H22N2OS/c25-22(19-8-6-18(7-9-19)20-11-13-26-16-20)23-21-10-12-24(15-21)14-17-4-2-1-3-5-17/h1-9,11,13,16,21H,10,12,14-15H2,(H,23,25)/t21-/m1/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 18 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
NPS Pharmaceuticals Inc.
Curated by ChEMBL
| Assay Description Ability to displace [3H]-spiperone from human Dopamine receptor D4.2 stably transfected in human embryonic kidney 298 cells |
Bioorg Med Chem Lett 14: 4847-50 (2004)
Article DOI: 10.1016/j.bmcl.2004.07.045 BindingDB Entry DOI: 10.7270/Q20C4V7D |
More data for this Ligand-Target Pair | |
D(2) dopamine receptor
(Homo sapiens (Human)) | BDBM82248
(CAS_73445-63-3 | SCH 23388 (S-enantiomer))Show InChI InChI=1S/C17H18ClNO/c1-19-8-7-13-9-16(18)17(20)10-14(13)15(11-19)12-5-3-2-4-6-12/h2-6,9-10,15,20H,7-8,11H2,1H3/t15-/m0/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
PC cid PC sid UniChem
Similars
| PubMed
| 20 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Northeastern University
Curated by ChEMBL
| Assay Description Ability to partially antagonise [3H]-SCH- 23388 binding to the Dopamine receptor D2 |
J Med Chem 31: 2069-71 (1988)
BindingDB Entry DOI: 10.7270/Q2B56K9S |
More data for this Ligand-Target Pair | |
D(4) dopamine receptor
(Homo sapiens (Human)) | BDBM50174002
(CHEMBL370652 | N-((S)-1-(4-(trifluoromethyl)benzyl...)Show SMILES FC(F)(F)c1ccc(CN2CC[C@@H](C2)NC(=O)c2cccc(c2)-c2cccs2)cc1 Show InChI InChI=1S/C23H21F3N2OS/c24-23(25,26)19-8-6-16(7-9-19)14-28-11-10-20(15-28)27-22(29)18-4-1-3-17(13-18)21-5-2-12-30-21/h1-9,12-13,20H,10-11,14-15H2,(H,27,29)/t20-/m0/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 21 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
NPS Pharmaceuticals
Curated by ChEMBL
| Assay Description Displacement of [3H]spiperone from cloned human dopamine D4.2 receptor in HEK298 cells |
Bioorg Med Chem Lett 15: 5253-6 (2005)
Article DOI: 10.1016/j.bmcl.2005.08.051 BindingDB Entry DOI: 10.7270/Q26D5TSR |
More data for this Ligand-Target Pair | |
D(4) dopamine receptor
(Homo sapiens (Human)) | BDBM50174012
((S)-N-(1-(3-(trifluoromethyl)benzyl)pyrrolidin-3-y...)Show SMILES FC(F)(F)c1cccc(CN2CC[C@@H](C2)NC(=O)c2ccc(cc2)-c2cccs2)c1 Show InChI InChI=1S/C23H21F3N2OS/c24-23(25,26)19-4-1-3-16(13-19)14-28-11-10-20(15-28)27-22(29)18-8-6-17(7-9-18)21-5-2-12-30-21/h1-9,12-13,20H,10-11,14-15H2,(H,27,29)/t20-/m0/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 22 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
NPS Pharmaceuticals
Curated by ChEMBL
| Assay Description Displacement of [3H]spiperone from cloned human dopamine D4.2 receptor in HEK298 cells |
Bioorg Med Chem Lett 15: 5253-6 (2005)
Article DOI: 10.1016/j.bmcl.2005.08.051 BindingDB Entry DOI: 10.7270/Q26D5TSR |
More data for this Ligand-Target Pair | |
5-hydroxytryptamine receptor 2A
(Homo sapiens (Human)) | BDBM50174003
((S)-N-(1-(3-methoxybenzyl)pyrrolidin-3-yl)-4-(thio...)Show SMILES COc1cccc(CN2CC[C@@H](C2)NC(=O)c2ccc(cc2)-c2cccs2)c1 Show InChI InChI=1S/C23H24N2O2S/c1-27-21-5-2-4-17(14-21)15-25-12-11-20(16-25)24-23(26)19-9-7-18(8-10-19)22-6-3-13-28-22/h2-10,13-14,20H,11-12,15-16H2,1H3,(H,24,26)/t20-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 22 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
NPS Pharmaceuticals
Curated by ChEMBL
| Assay Description Displacement of [3H]ketanserin from cloned human 5HT2A receptor in HEK298 cells |
Bioorg Med Chem Lett 15: 5253-6 (2005)
Article DOI: 10.1016/j.bmcl.2005.08.051 BindingDB Entry DOI: 10.7270/Q26D5TSR |
More data for this Ligand-Target Pair | |
5-hydroxytryptamine receptor 2A
(Homo sapiens (Human)) | BDBM50174010
((S)-N-(1-(3,4-dichlorobenzyl)pyrrolidin-3-yl)-4-(t...)Show SMILES Clc1ccc(CN2CC[C@@H](C2)NC(=O)c2ccc(cc2)-c2cccs2)cc1Cl Show InChI InChI=1S/C22H20Cl2N2OS/c23-19-8-3-15(12-20(19)24)13-26-10-9-18(14-26)25-22(27)17-6-4-16(5-7-17)21-2-1-11-28-21/h1-8,11-12,18H,9-10,13-14H2,(H,25,27)/t18-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 22 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
NPS Pharmaceuticals
Curated by ChEMBL
| Assay Description Displacement of [3H]ketanserin from cloned human 5HT2A receptor in HEK298 cells |
Bioorg Med Chem Lett 15: 5253-6 (2005)
Article DOI: 10.1016/j.bmcl.2005.08.051 BindingDB Entry DOI: 10.7270/Q26D5TSR |
More data for this Ligand-Target Pair | |
D(4) dopamine receptor
(Homo sapiens (Human)) | BDBM50152307
(CHEMBL186558 | N-((R)-1-Benzyl-pyrrolidin-3-yl)-4-...)Show SMILES O=C(N[C@@H]1CCN(Cc2ccccc2)C1)c1ccc(cc1)-c1cccs1 Show InChI InChI=1S/C22H22N2OS/c25-22(19-10-8-18(9-11-19)21-7-4-14-26-21)23-20-12-13-24(16-20)15-17-5-2-1-3-6-17/h1-11,14,20H,12-13,15-16H2,(H,23,25)/t20-/m1/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 24 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
NPS Pharmaceuticals Inc.
Curated by ChEMBL
| Assay Description Ability to displace [3H]-spiperone from human Dopamine receptor D4.2 stably transfected in human embryonic kidney 298 cells |
Bioorg Med Chem Lett 14: 4847-50 (2004)
Article DOI: 10.1016/j.bmcl.2004.07.045 BindingDB Entry DOI: 10.7270/Q20C4V7D |
More data for this Ligand-Target Pair | |
D(1A) dopamine receptor
(Homo sapiens (Human)) | BDBM81485
(CAS_68751 | CIS TEFLUTIXOL | NSC_68751 | Teflutixo...)Show SMILES OCCN1CCN(CCCC2c3ccc(F)cc3Sc3ccc(cc23)C(F)(F)F)CC1 Show InChI InChI=1S/C23H26F4N2OS/c24-17-4-5-19-18(2-1-7-28-8-10-29(11-9-28)12-13-30)20-14-16(23(25,26)27)3-6-21(20)31-22(19)15-17/h3-6,14-15,18,30H,1-2,7-13H2 | PDB
KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Patents
| Article PubMed
| 24 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Duke University
Curated by PDSP Ki Database
| |
Proc Natl Acad Sci U S A 88: 7491-5 (1991)
Article DOI: 10.1073/pnas.88.17.7491 BindingDB Entry DOI: 10.7270/Q2DB80B9 |
More data for this Ligand-Target Pair | |
D(4) dopamine receptor
(Homo sapiens (Human)) | BDBM50152304
(3''-Amino-biphenyl-4-carboxylic acid (1-benzyl-pyr...)Show SMILES Nc1cccc(c1)-c1ccc(cc1)C(=O)NC1CCN(Cc2ccccc2)C1 Show InChI InChI=1S/C24H25N3O/c25-22-8-4-7-21(15-22)19-9-11-20(12-10-19)24(28)26-23-13-14-27(17-23)16-18-5-2-1-3-6-18/h1-12,15,23H,13-14,16-17,25H2,(H,26,28) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 24 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
NPS Pharmaceuticals Inc.
Curated by ChEMBL
| Assay Description Ability to displace [3H]-spiperone from human Dopamine receptor D4.2 stably transfected in human embryonic kidney 298 cells |
Bioorg Med Chem Lett 14: 4847-50 (2004)
Article DOI: 10.1016/j.bmcl.2004.07.045 BindingDB Entry DOI: 10.7270/Q20C4V7D |
More data for this Ligand-Target Pair | |
D(1A) dopamine receptor
(Homo sapiens (Human)) | BDBM21398
(4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1...)Show SMILES OC1(CCN(CCCC(=O)c2ccc(F)cc2)CC1)c1ccc(Cl)cc1 Show InChI InChI=1S/C21H23ClFNO2/c22-18-7-5-17(6-8-18)21(26)11-14-24(15-12-21)13-1-2-20(25)16-3-9-19(23)10-4-16/h3-10,26H,1-2,11-15H2 | PDB
KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem
Patents
Similars
| DrugBank Article PubMed
| 24 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Duke University
Curated by PDSP Ki Database
| |
Proc Natl Acad Sci U S A 88: 7491-5 (1991)
Article DOI: 10.1073/pnas.88.17.7491 BindingDB Entry DOI: 10.7270/Q2DB80B9 |
More data for this Ligand-Target Pair | |