Found 68 hits with Last Name = 'koester' and Initial = 'tj' Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM5284
(4-{[4-(Methylsulfonyl)piperazin-1-yl]methyl}-N-(5-...)Show SMILES CS(=O)(=O)N1CCN(Cc2ccnc(Nc3ncc(s3)-c3ccccc3)c2)CC1 Show InChI InChI=1S/C20H23N5O2S2/c1-29(26,27)25-11-9-24(10-12-25)15-16-7-8-21-19(13-16)23-20-22-14-18(28-20)17-5-3-2-4-6-17/h2-8,13-14H,9-12,15H2,1H3,(H,21,22,23) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 2 | n/a | n/a | n/a | n/a | 7.4 | 22 |
Merck Research Laboratories
| Assay Description Activated KDR was incubated with 25 uM/10 uCi of [gamma-33P] ATP, poly-Glu/Tyr, and inhibitors in kinase buffer for 15 min at 22 °C. The reactio... |
J Med Chem 47: 6363-72 (2004)
Article DOI: 10.1021/jm049697f BindingDB Entry DOI: 10.7270/Q2PG1PXD |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM5358
(N-(6-methoxypyridin-2-yl)-5-phenyl-1,3-thiazol-2-a...)Show InChI InChI=1S/C15H13N3OS/c1-19-14-9-5-8-13(17-14)18-15-16-10-12(20-15)11-6-3-2-4-7-11/h2-10H,1H3,(H,16,17,18) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 3 | n/a | n/a | n/a | n/a | 7.4 | 22 |
Merck Research Laboratories
| Assay Description Activated KDR was incubated with 25 uM/10 uCi of [gamma-33P] ATP, poly-Glu/Tyr, and inhibitors in kinase buffer for 15 min at 22 °C. The reactio... |
Bioorg Med Chem Lett 14: 2941-5 (2004)
Article DOI: 10.1016/j.bmcl.2004.03.052 BindingDB Entry DOI: 10.7270/Q25H7DG7 |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM5282
((5-Phenylthiazol-2-yl)(4-pyrrolidin-1-ylmethylpyri...)Show InChI InChI=1S/C19H20N4S/c1-2-6-16(7-3-1)17-13-21-19(24-17)22-18-12-15(8-9-20-18)14-23-10-4-5-11-23/h1-3,6-9,12-13H,4-5,10-11,14H2,(H,20,21,22) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 3 | n/a | n/a | n/a | n/a | 7.4 | 22 |
Merck Research Laboratories
| Assay Description Activated KDR was incubated with 25 uM/10 uCi of [gamma-33P] ATP, poly-Glu/Tyr, and inhibitors in kinase buffer for 15 min at 22 °C. The reactio... |
J Med Chem 47: 6363-72 (2004)
Article DOI: 10.1021/jm049697f BindingDB Entry DOI: 10.7270/Q2PG1PXD |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM5281
(5-phenyl-N-[5-(pyrrolidin-1-ylmethyl)pyridin-2-yl]...)Show InChI InChI=1S/C19H20N4S/c1-2-6-16(7-3-1)17-13-21-19(24-17)22-18-9-8-15(12-20-18)14-23-10-4-5-11-23/h1-3,6-9,12-13H,4-5,10-11,14H2,(H,20,21,22) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 6 | n/a | n/a | n/a | n/a | 7.4 | 22 |
Merck Research Laboratories
| Assay Description Activated KDR was incubated with 25 uM/10 uCi of [gamma-33P] ATP, poly-Glu/Tyr, and inhibitors in kinase buffer for 15 min at 22 °C. The reactio... |
J Med Chem 47: 6363-72 (2004)
Article DOI: 10.1021/jm049697f BindingDB Entry DOI: 10.7270/Q2PG1PXD |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM5281
(5-phenyl-N-[5-(pyrrolidin-1-ylmethyl)pyridin-2-yl]...)Show InChI InChI=1S/C19H20N4S/c1-2-6-16(7-3-1)17-13-21-19(24-17)22-18-9-8-15(12-20-18)14-23-10-4-5-11-23/h1-3,6-9,12-13H,4-5,10-11,14H2,(H,20,21,22) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 6 | n/a | n/a | n/a | n/a | 7.4 | 22 |
Merck Research Laboratories
| Assay Description Activated KDR was incubated with 25 uM/10 uCi of [gamma-33P] ATP, poly-Glu/Tyr, and inhibitors in kinase buffer for 15 min at 22 °C. The reactio... |
Bioorg Med Chem Lett 14: 2941-5 (2004)
Article DOI: 10.1016/j.bmcl.2004.03.052 BindingDB Entry DOI: 10.7270/Q25H7DG7 |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM5351
(N-(4-methylpyridin-2-yl)-5-phenyl-1,3-thiazol-2-am...)Show InChI InChI=1S/C15H13N3S/c1-11-7-8-16-14(9-11)18-15-17-10-13(19-15)12-5-3-2-4-6-12/h2-10H,1H3,(H,16,17,18) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 6 | n/a | n/a | n/a | n/a | 7.4 | 22 |
Merck Research Laboratories
| Assay Description Activated KDR was incubated with 25 uM/10 uCi of [gamma-33P] ATP, poly-Glu/Tyr, and inhibitors in kinase buffer for 15 min at 22 °C. The reactio... |
Bioorg Med Chem Lett 14: 2941-5 (2004)
Article DOI: 10.1016/j.bmcl.2004.03.052 BindingDB Entry DOI: 10.7270/Q25H7DG7 |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM5292
(2-({4-[(4-methanesulfonylpiperidin-1-yl)methyl]pyr...)Show SMILES CS(=O)(=O)C1CCN(Cc2ccnc(Nc3ncc(s3)C#N)c2)CC1 Show InChI InChI=1S/C16H19N5O2S2/c1-25(22,23)14-3-6-21(7-4-14)11-12-2-5-18-15(8-12)20-16-19-10-13(9-17)24-16/h2,5,8,10,14H,3-4,6-7,11H2,1H3,(H,18,19,20) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Patents
| Article PubMed
| n/a | n/a | 7 | n/a | n/a | n/a | n/a | 7.4 | 22 |
Merck Research Laboratories
| Assay Description Activated KDR was incubated with 25 uM/10 uCi of [gamma-33P] ATP, poly-Glu/Tyr, and inhibitors in kinase buffer for 15 min at 22 °C. The reactio... |
J Med Chem 47: 6363-72 (2004)
Article DOI: 10.1021/jm049697f BindingDB Entry DOI: 10.7270/Q2PG1PXD |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM5280
(5-phenyl-N-(pyridin-2-yl)-1,3-thiazol-2-amine | N-...)Show InChI InChI=1S/C14H11N3S/c1-2-6-11(7-3-1)12-10-16-14(18-12)17-13-8-4-5-9-15-13/h1-10H,(H,15,16,17) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 7 | n/a | n/a | n/a | n/a | 7.4 | 22 |
Merck Research Laboratories
| Assay Description Activated KDR was incubated with 25 uM/10 uCi of [gamma-33P] ATP, poly-Glu/Tyr, and inhibitors in kinase buffer for 15 min at 22 °C. The reactio... |
J Med Chem 47: 6363-72 (2004)
Article DOI: 10.1021/jm049697f BindingDB Entry DOI: 10.7270/Q2PG1PXD |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM5283
(1-[4-({2-[(5-phenyl-1,3-thiazol-2-yl)amino]pyridin...)Show SMILES CC(=O)N1CCN(Cc2ccnc(Nc3ncc(s3)-c3ccccc3)c2)CC1 Show InChI InChI=1S/C21H23N5OS/c1-16(27)26-11-9-25(10-12-26)15-17-7-8-22-20(13-17)24-21-23-14-19(28-21)18-5-3-2-4-6-18/h2-8,13-14H,9-12,15H2,1H3,(H,22,23,24) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 8 | n/a | n/a | n/a | n/a | 7.4 | 22 |
Merck Research Laboratories
| Assay Description Activated KDR was incubated with 25 uM/10 uCi of [gamma-33P] ATP, poly-Glu/Tyr, and inhibitors in kinase buffer for 15 min at 22 °C. The reactio... |
J Med Chem 47: 6363-72 (2004)
Article DOI: 10.1021/jm049697f BindingDB Entry DOI: 10.7270/Q2PG1PXD |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM5287
(2-(4-Morpholin-4-ylmethylpyridin-2-ylamino)thiazol...)Show InChI InChI=1S/C14H15N5OS/c15-8-12-9-17-14(21-12)18-13-7-11(1-2-16-13)10-19-3-5-20-6-4-19/h1-2,7,9H,3-6,10H2,(H,16,17,18) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 8 | n/a | n/a | n/a | n/a | 7.4 | 22 |
Merck Research Laboratories
| Assay Description Activated KDR was incubated with 25 uM/10 uCi of [gamma-33P] ATP, poly-Glu/Tyr, and inhibitors in kinase buffer for 15 min at 22 °C. The reactio... |
J Med Chem 47: 6363-72 (2004)
Article DOI: 10.1021/jm049697f BindingDB Entry DOI: 10.7270/Q2PG1PXD |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM5288
(4-({2-[(5-Cyano-1,3-thiazol-2-yl)amino]-4-pyridiny...)Show InChI InChI=1S/C15H17N7OS/c16-8-12-9-19-15(24-12)20-13-7-11(1-2-18-13)10-21-3-5-22(6-4-21)14(17)23/h1-2,7,9H,3-6,10H2,(H2,17,23)(H,18,19,20) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 8 | n/a | n/a | n/a | n/a | 7.4 | 22 |
Merck Research Laboratories
| Assay Description Activated KDR was incubated with 25 uM/10 uCi of [gamma-33P] ATP, poly-Glu/Tyr, and inhibitors in kinase buffer for 15 min at 22 °C. The reactio... |
J Med Chem 47: 6363-72 (2004)
Article DOI: 10.1021/jm049697f BindingDB Entry DOI: 10.7270/Q2PG1PXD |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM5291
(2-[(4-{[4-(2-hydroxyacetyl)piperazin-1-yl]methyl}p...)Show InChI InChI=1S/C16H18N6O2S/c17-8-13-9-19-16(25-13)20-14-7-12(1-2-18-14)10-21-3-5-22(6-4-21)15(24)11-23/h1-2,7,9,23H,3-6,10-11H2,(H,18,19,20) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 9 | n/a | n/a | n/a | n/a | 7.4 | 22 |
Merck Research Laboratories
| Assay Description Activated KDR was incubated with 25 uM/10 uCi of [gamma-33P] ATP, poly-Glu/Tyr, and inhibitors in kinase buffer for 15 min at 22 °C. The reactio... |
J Med Chem 47: 6363-72 (2004)
Article DOI: 10.1021/jm049697f BindingDB Entry DOI: 10.7270/Q2PG1PXD |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50179415
(2-(6-(4-(2-methoxyethyl)piperazin-1-yl)pyrimidin-4...)Show InChI InChI=1S/C15H19N7OS/c1-23-7-6-21-2-4-22(5-3-21)14-8-13(18-11-19-14)20-15-17-10-12(9-16)24-15/h8,10-11H,2-7H2,1H3,(H,17,18,19,20) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 9 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description Inhibition of KDR |
Bioorg Med Chem Lett 16: 1146-50 (2006)
Article DOI: 10.1016/j.bmcl.2005.11.089 BindingDB Entry DOI: 10.7270/Q279448N |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50179418
(2-(6-(4-aminoazepan-1-yl)pyrimidin-4-ylamino)thiaz...)Show InChI InChI=1S/C14H17N7S/c15-7-11-8-17-14(22-11)20-12-6-13(19-9-18-12)21-4-1-2-10(16)3-5-21/h6,8-10H,1-5,16H2,(H,17,18,19,20) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 9 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description Inhibition of KDR |
Bioorg Med Chem Lett 16: 1146-50 (2006)
Article DOI: 10.1016/j.bmcl.2005.11.089 BindingDB Entry DOI: 10.7270/Q279448N |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50179427
(2-(6-(4-(2-(pyrrolidin-1-yl)ethyl)piperazin-1-yl)p...)Show InChI InChI=1S/C18H24N8S/c19-12-15-13-20-18(27-15)23-16-11-17(22-14-21-16)26-9-7-25(8-10-26)6-5-24-3-1-2-4-24/h11,13-14H,1-10H2,(H,20,21,22,23) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 9 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description Inhibition of KDR |
Bioorg Med Chem Lett 16: 1146-50 (2006)
Article DOI: 10.1016/j.bmcl.2005.11.089 BindingDB Entry DOI: 10.7270/Q279448N |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM5353
(N-(6-methylpyridin-2-yl)-5-phenyl-1,3-thiazol-2-am...)Show InChI InChI=1S/C15H13N3S/c1-11-6-5-9-14(17-11)18-15-16-10-13(19-15)12-7-3-2-4-8-12/h2-10H,1H3,(H,16,17,18) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 10 | n/a | n/a | n/a | n/a | 7.4 | 22 |
Merck Research Laboratories
| Assay Description Activated KDR was incubated with 25 uM/10 uCi of [gamma-33P] ATP, poly-Glu/Tyr, and inhibitors in kinase buffer for 15 min at 22 °C. The reactio... |
Bioorg Med Chem Lett 14: 2941-5 (2004)
Article DOI: 10.1016/j.bmcl.2004.03.052 BindingDB Entry DOI: 10.7270/Q25H7DG7 |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50179413
(2-(6-(4-aminopiperidin-1-yl)pyrimidin-4-ylamino)th...)Show InChI InChI=1S/C13H15N7S/c14-6-10-7-16-13(21-10)19-11-5-12(18-8-17-11)20-3-1-9(15)2-4-20/h5,7-9H,1-4,15H2,(H,16,17,18,19) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description Inhibition of KDR |
Bioorg Med Chem Lett 16: 1146-50 (2006)
Article DOI: 10.1016/j.bmcl.2005.11.089 BindingDB Entry DOI: 10.7270/Q279448N |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50179420
(2-(6-(4-(3-morpholinopropyl)piperazin-1-yl)pyrimid...)Show SMILES N#Cc1cnc(Nc2cc(ncn2)N2CCN(CCCN3CCOCC3)CC2)s1 Show InChI InChI=1S/C19H26N8OS/c20-13-16-14-21-19(29-16)24-17-12-18(23-15-22-17)27-6-4-25(5-7-27)2-1-3-26-8-10-28-11-9-26/h12,14-15H,1-11H2,(H,21,22,23,24) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description Inhibition of KDR |
Bioorg Med Chem Lett 16: 1146-50 (2006)
Article DOI: 10.1016/j.bmcl.2005.11.089 BindingDB Entry DOI: 10.7270/Q279448N |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM5289
(4-({2-[(5-Cyano-1,3-thiazol-2-yl)amino]-4-pyridiny...)Show SMILES CN(C)C(=O)N1CCN(Cc2ccnc(Nc3ncc(s3)C#N)c2)CC1 Show InChI InChI=1S/C17H21N7OS/c1-22(2)17(25)24-7-5-23(6-8-24)12-13-3-4-19-15(9-13)21-16-20-11-14(10-18)26-16/h3-4,9,11H,5-8,12H2,1-2H3,(H,19,20,21) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 10 | n/a | n/a | n/a | n/a | 7.4 | 22 |
Merck Research Laboratories
| Assay Description Activated KDR was incubated with 25 uM/10 uCi of [gamma-33P] ATP, poly-Glu/Tyr, and inhibitors in kinase buffer for 15 min at 22 °C. The reactio... |
J Med Chem 47: 6363-72 (2004)
Article DOI: 10.1021/jm049697f BindingDB Entry DOI: 10.7270/Q2PG1PXD |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50179417
(2-(6-(4-methylpiperazin-1-yl)pyrimidin-4-ylamino)t...)Show InChI InChI=1S/C13H15N7S/c1-19-2-4-20(5-3-19)12-6-11(16-9-17-12)18-13-15-8-10(7-14)21-13/h6,8-9H,2-5H2,1H3,(H,15,16,17,18) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description Inhibition of KDR |
Bioorg Med Chem Lett 16: 1146-50 (2006)
Article DOI: 10.1016/j.bmcl.2005.11.089 BindingDB Entry DOI: 10.7270/Q279448N |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM5357
(N-(4-methoxypyridin-2-yl)-5-phenyl-1,3-thiazol-2-a...)Show InChI InChI=1S/C15H13N3OS/c1-19-12-7-8-16-14(9-12)18-15-17-10-13(20-15)11-5-3-2-4-6-11/h2-10H,1H3,(H,16,17,18) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 11 | n/a | n/a | n/a | n/a | 7.4 | 22 |
Merck Research Laboratories
| Assay Description Activated KDR was incubated with 25 uM/10 uCi of [gamma-33P] ATP, poly-Glu/Tyr, and inhibitors in kinase buffer for 15 min at 22 °C. The reactio... |
Bioorg Med Chem Lett 14: 2941-5 (2004)
Article DOI: 10.1016/j.bmcl.2004.03.052 BindingDB Entry DOI: 10.7270/Q25H7DG7 |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50179427
(2-(6-(4-(2-(pyrrolidin-1-yl)ethyl)piperazin-1-yl)p...)Show InChI InChI=1S/C18H24N8S/c19-12-15-13-20-18(27-15)23-16-11-17(22-14-21-16)26-9-7-25(8-10-26)6-5-24-3-1-2-4-24/h11,13-14H,1-10H2,(H,20,21,22,23) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 11 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description Inhibition of human KDR expressed in HEK293 cells by KDR autophosphorylation assay |
Bioorg Med Chem Lett 16: 1146-50 (2006)
Article DOI: 10.1016/j.bmcl.2005.11.089 BindingDB Entry DOI: 10.7270/Q279448N |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50179414
(2-(6-(4-(2-morpholinoethyl)piperazin-1-yl)pyrimidi...)Show SMILES N#Cc1cnc(Nc2cc(ncn2)N2CCN(CCN3CCOCC3)CC2)s1 Show InChI InChI=1S/C18H24N8OS/c19-12-15-13-20-18(28-15)23-16-11-17(22-14-21-16)26-5-3-24(4-6-26)1-2-25-7-9-27-10-8-25/h11,13-14H,1-10H2,(H,20,21,22,23) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 12 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description Inhibition of KDR |
Bioorg Med Chem Lett 16: 1146-50 (2006)
Article DOI: 10.1016/j.bmcl.2005.11.089 BindingDB Entry DOI: 10.7270/Q279448N |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM5293
(4-({2-[(5-cyano-1,3-thiazol-2-yl)amino]-3-methylpy...)Show InChI InChI=1S/C17H21N7OS/c1-12-13(11-23-5-7-24(8-6-23)17(25)19-2)3-4-20-15(12)22-16-21-10-14(9-18)26-16/h3-4,10H,5-8,11H2,1-2H3,(H,19,25)(H,20,21,22) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 12 | n/a | n/a | n/a | n/a | 7.4 | 22 |
Merck Research Laboratories
| Assay Description Activated KDR was incubated with 25 uM/10 uCi of [gamma-33P] ATP, poly-Glu/Tyr, and inhibitors in kinase buffer for 15 min at 22 °C. The reactio... |
J Med Chem 47: 6363-72 (2004)
Article DOI: 10.1021/jm049697f BindingDB Entry DOI: 10.7270/Q2PG1PXD |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM5290
(4-({2-[(5-cyano-1,3-thiazol-2-yl)amino]pyridin-4-y...)Show InChI InChI=1S/C16H19N7OS/c1-18-16(24)23-6-4-22(5-7-23)11-12-2-3-19-14(8-12)21-15-20-10-13(9-17)25-15/h2-3,8,10H,4-7,11H2,1H3,(H,18,24)(H,19,20,21) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 12 | n/a | n/a | n/a | n/a | 7.4 | 22 |
Merck Research Laboratories
| Assay Description Activated KDR was incubated with 25 uM/10 uCi of [gamma-33P] ATP, poly-Glu/Tyr, and inhibitors in kinase buffer for 15 min at 22 °C. The reactio... |
J Med Chem 47: 6363-72 (2004)
Article DOI: 10.1021/jm049697f BindingDB Entry DOI: 10.7270/Q2PG1PXD |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM5350
(N-(3-methylpyridin-2-yl)-5-phenyl-1,3-thiazol-2-am...)Show InChI InChI=1S/C15H13N3S/c1-11-6-5-9-16-14(11)18-15-17-10-13(19-15)12-7-3-2-4-8-12/h2-10H,1H3,(H,16,17,18) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 13 | n/a | n/a | n/a | n/a | 7.4 | 22 |
Merck Research Laboratories
| Assay Description Activated KDR was incubated with 25 uM/10 uCi of [gamma-33P] ATP, poly-Glu/Tyr, and inhibitors in kinase buffer for 15 min at 22 °C. The reactio... |
Bioorg Med Chem Lett 14: 2941-5 (2004)
Article DOI: 10.1016/j.bmcl.2004.03.052 BindingDB Entry DOI: 10.7270/Q25H7DG7 |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50179416
(2-(6-(4-acetylpiperazin-1-yl)pyrimidin-4-ylamino)t...)Show InChI InChI=1S/C14H15N7OS/c1-10(22)20-2-4-21(5-3-20)13-6-12(17-9-18-13)19-14-16-8-11(7-15)23-14/h6,8-9H,2-5H2,1H3,(H,16,17,18,19) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 13 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description Inhibition of KDR |
Bioorg Med Chem Lett 16: 1146-50 (2006)
Article DOI: 10.1016/j.bmcl.2005.11.089 BindingDB Entry DOI: 10.7270/Q279448N |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM5285
(2-({4-[(4-acetylpiperazin-1-yl)methyl]pyridin-2-yl...)Show InChI InChI=1S/C16H18N6OS/c1-12(23)22-6-4-21(5-7-22)11-13-2-3-18-15(8-13)20-16-19-10-14(9-17)24-16/h2-3,8,10H,4-7,11H2,1H3,(H,18,19,20) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 13 | n/a | n/a | n/a | n/a | 7.4 | 22 |
Merck Research Laboratories
| Assay Description Activated KDR was incubated with 25 uM/10 uCi of [gamma-33P] ATP, poly-Glu/Tyr, and inhibitors in kinase buffer for 15 min at 22 °C. The reactio... |
J Med Chem 47: 6363-72 (2004)
Article DOI: 10.1021/jm049697f BindingDB Entry DOI: 10.7270/Q2PG1PXD |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM5355
(N-(6-bromopyridin-2-yl)-5-phenyl-1,3-thiazol-2-ami...)Show InChI InChI=1S/C14H10BrN3S/c15-12-7-4-8-13(17-12)18-14-16-9-11(19-14)10-5-2-1-3-6-10/h1-9H,(H,16,17,18) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 14 | n/a | n/a | n/a | n/a | 7.4 | 22 |
Merck Research Laboratories
| Assay Description Activated KDR was incubated with 25 uM/10 uCi of [gamma-33P] ATP, poly-Glu/Tyr, and inhibitors in kinase buffer for 15 min at 22 °C. The reactio... |
Bioorg Med Chem Lett 14: 2941-5 (2004)
Article DOI: 10.1016/j.bmcl.2004.03.052 BindingDB Entry DOI: 10.7270/Q25H7DG7 |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM5375
(1-phenyl-5-{4-[2-(piperidin-1-yl)ethoxy]phenyl}-1H...)Show SMILES C(CN1CCCCC1)Oc1ccc(cc1)-c1ccc2n(cnc2c1)-c1ccccc1 Show InChI InChI=1S/C26H27N3O/c1-3-7-23(8-4-1)29-20-27-25-19-22(11-14-26(25)29)21-9-12-24(13-10-21)30-18-17-28-15-5-2-6-16-28/h1,3-4,7-14,19-20H,2,5-6,15-18H2 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Patents
| Article PubMed
| n/a | n/a | 14 | n/a | n/a | n/a | n/a | 7.4 | 22 |
Merck Research Laboratories
| Assay Description Activated KDR was incubated with 25 uM/10 uCi of [gamma-33P] ATP, poly-Glu/Tyr, and inhibitors in kinase buffer for 15 min at 22 °C. The reactio... |
Bioorg Med Chem Lett 13: 2485-8 (2003)
Article DOI: 10.1016/s0960-894x(03)00485-2 BindingDB Entry DOI: 10.7270/Q21R6NQ2 |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM5286
(2-(4-Piperazin-1-ylmethylpyridin-2-ylamino)thiazol...)Show InChI InChI=1S/C14H16N6S/c15-8-12-9-18-14(21-12)19-13-7-11(1-2-17-13)10-20-5-3-16-4-6-20/h1-2,7,9,16H,3-6,10H2,(H,17,18,19) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 15 | n/a | n/a | n/a | n/a | 7.4 | 22 |
Merck Research Laboratories
| Assay Description Activated KDR was incubated with 25 uM/10 uCi of [gamma-33P] ATP, poly-Glu/Tyr, and inhibitors in kinase buffer for 15 min at 22 °C. The reactio... |
J Med Chem 47: 6363-72 (2004)
Article DOI: 10.1021/jm049697f BindingDB Entry DOI: 10.7270/Q2PG1PXD |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50179418
(2-(6-(4-aminoazepan-1-yl)pyrimidin-4-ylamino)thiaz...)Show InChI InChI=1S/C14H17N7S/c15-7-11-8-17-14(22-11)20-12-6-13(19-9-18-12)21-4-1-2-10(16)3-5-21/h6,8-10H,1-5,16H2,(H,17,18,19,20) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 15 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description Inhibition of human KDR expressed in HEK293 cells by KDR autophosphorylation assay |
Bioorg Med Chem Lett 16: 1146-50 (2006)
Article DOI: 10.1016/j.bmcl.2005.11.089 BindingDB Entry DOI: 10.7270/Q279448N |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50179421
((rac)-2-(6-(3-aminopyrrolidin-1-yl)pyrimidin-4-yla...)Show InChI InChI=1S/C12H13N7S/c13-4-9-5-15-12(20-9)18-10-3-11(17-7-16-10)19-2-1-8(14)6-19/h3,5,7-8H,1-2,6,14H2,(H,15,16,17,18) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 16 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description Inhibition of KDR |
Bioorg Med Chem Lett 16: 1146-50 (2006)
Article DOI: 10.1016/j.bmcl.2005.11.089 BindingDB Entry DOI: 10.7270/Q279448N |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50179422
(2-(6-(piperazin-1-yl)pyrimidin-4-ylamino)thiazole-...)Show InChI InChI=1S/C12H13N7S/c13-6-9-7-15-12(20-9)18-10-5-11(17-8-16-10)19-3-1-14-2-4-19/h5,7-8,14H,1-4H2,(H,15,16,17,18) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 16 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description Inhibition of KDR |
Bioorg Med Chem Lett 16: 1146-50 (2006)
Article DOI: 10.1016/j.bmcl.2005.11.089 BindingDB Entry DOI: 10.7270/Q279448N |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50179414
(2-(6-(4-(2-morpholinoethyl)piperazin-1-yl)pyrimidi...)Show SMILES N#Cc1cnc(Nc2cc(ncn2)N2CCN(CCN3CCOCC3)CC2)s1 Show InChI InChI=1S/C18H24N8OS/c19-12-15-13-20-18(28-15)23-16-11-17(22-14-21-16)26-5-3-24(4-6-26)1-2-25-7-9-27-10-8-25/h11,13-14H,1-10H2,(H,20,21,22,23) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 19 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description Inhibition of human KDR expressed in HEK293 cells by KDR autophosphorylation assay |
Bioorg Med Chem Lett 16: 1146-50 (2006)
Article DOI: 10.1016/j.bmcl.2005.11.089 BindingDB Entry DOI: 10.7270/Q279448N |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM5352
(N-(5-methylpyridin-2-yl)-5-phenyl-1,3-thiazol-2-am...)Show InChI InChI=1S/C15H13N3S/c1-11-7-8-14(16-9-11)18-15-17-10-13(19-15)12-5-3-2-4-6-12/h2-10H,1H3,(H,16,17,18) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 19 | n/a | n/a | n/a | n/a | 7.4 | 22 |
Merck Research Laboratories
| Assay Description Activated KDR was incubated with 25 uM/10 uCi of [gamma-33P] ATP, poly-Glu/Tyr, and inhibitors in kinase buffer for 15 min at 22 °C. The reactio... |
Bioorg Med Chem Lett 14: 2941-5 (2004)
Article DOI: 10.1016/j.bmcl.2004.03.052 BindingDB Entry DOI: 10.7270/Q25H7DG7 |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50179421
((rac)-2-(6-(3-aminopyrrolidin-1-yl)pyrimidin-4-yla...)Show InChI InChI=1S/C12H13N7S/c13-4-9-5-15-12(20-9)18-10-3-11(17-7-16-10)19-2-1-8(14)6-19/h3,5,7-8H,1-2,6,14H2,(H,15,16,17,18) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 21 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description Inhibition of human KDR expressed in HEK293 cells by KDR autophosphorylation assay |
Bioorg Med Chem Lett 16: 1146-50 (2006)
Article DOI: 10.1016/j.bmcl.2005.11.089 BindingDB Entry DOI: 10.7270/Q279448N |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50179415
(2-(6-(4-(2-methoxyethyl)piperazin-1-yl)pyrimidin-4...)Show InChI InChI=1S/C15H19N7OS/c1-23-7-6-21-2-4-22(5-3-21)14-8-13(18-11-19-14)20-15-17-10-12(9-16)24-15/h8,10-11H,2-7H2,1H3,(H,17,18,19,20) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 22 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description Inhibition of human KDR expressed in HEK293 cells by KDR autophosphorylation assay |
Bioorg Med Chem Lett 16: 1146-50 (2006)
Article DOI: 10.1016/j.bmcl.2005.11.089 BindingDB Entry DOI: 10.7270/Q279448N |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM5366
(1-phenyl-5-{6-[2-(piperidin-1-yl)ethoxy]pyridin-3-...)Show SMILES C(CN1CCCCC1)Oc1ccc(cn1)-c1ccc2n(cnc2c1)-c1ccccc1 Show InChI InChI=1S/C25H26N4O/c1-3-7-22(8-4-1)29-19-27-23-17-20(9-11-24(23)29)21-10-12-25(26-18-21)30-16-15-28-13-5-2-6-14-28/h1,3-4,7-12,17-19H,2,5-6,13-16H2 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Patents
| Article PubMed
| n/a | n/a | 23 | n/a | n/a | n/a | n/a | 7.4 | 22 |
Merck Research Laboratories
| Assay Description Activated KDR was incubated with 25 uM/10 uCi of [gamma-33P] ATP, poly-Glu/Tyr, and inhibitors in kinase buffer for 15 min at 22 °C. The reactio... |
Bioorg Med Chem Lett 13: 2485-8 (2003)
Article DOI: 10.1016/s0960-894x(03)00485-2 BindingDB Entry DOI: 10.7270/Q21R6NQ2 |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50179420
(2-(6-(4-(3-morpholinopropyl)piperazin-1-yl)pyrimid...)Show SMILES N#Cc1cnc(Nc2cc(ncn2)N2CCN(CCCN3CCOCC3)CC2)s1 Show InChI InChI=1S/C19H26N8OS/c20-13-16-14-21-19(29-16)24-17-12-18(23-15-22-17)27-6-4-25(5-7-27)2-1-3-26-8-10-28-11-9-26/h12,14-15H,1-11H2,(H,21,22,23,24) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 23 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description Inhibition of human KDR expressed in HEK293 cells by KDR autophosphorylation assay |
Bioorg Med Chem Lett 16: 1146-50 (2006)
Article DOI: 10.1016/j.bmcl.2005.11.089 BindingDB Entry DOI: 10.7270/Q279448N |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50179417
(2-(6-(4-methylpiperazin-1-yl)pyrimidin-4-ylamino)t...)Show InChI InChI=1S/C13H15N7S/c1-19-2-4-20(5-3-19)12-6-11(16-9-17-12)18-13-15-8-10(7-14)21-13/h6,8-9H,2-5H2,1H3,(H,15,16,17,18) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 23 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description Inhibition of human KDR expressed in HEK293 cells by KDR autophosphorylation assay |
Bioorg Med Chem Lett 16: 1146-50 (2006)
Article DOI: 10.1016/j.bmcl.2005.11.089 BindingDB Entry DOI: 10.7270/Q279448N |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM5368
(4-(1-phenyl-1H-1,3-benzodiazol-5-yl)-1-[3-(piperid...)Show SMILES O=c1cc(ccn1CCCN1CCCCC1)-c1ccc2n(cnc2c1)-c1ccccc1 Show InChI InChI=1S/C26H28N4O/c31-26-19-22(12-17-29(26)16-7-15-28-13-5-2-6-14-28)21-10-11-25-24(18-21)27-20-30(25)23-8-3-1-4-9-23/h1,3-4,8-12,17-20H,2,5-7,13-16H2 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 25 | n/a | n/a | n/a | n/a | 7.4 | 22 |
Merck Research Laboratories
| Assay Description Activated KDR was incubated with 25 uM/10 uCi of [gamma-33P] ATP, poly-Glu/Tyr, and inhibitors in kinase buffer for 15 min at 22 °C. The reactio... |
Bioorg Med Chem Lett 13: 2485-8 (2003)
Article DOI: 10.1016/s0960-894x(03)00485-2 BindingDB Entry DOI: 10.7270/Q21R6NQ2 |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50179423
(2-(6-(1,4-diazepan-1-yl)pyrimidin-4-ylamino)thiazo...)Show InChI InChI=1S/C13H15N7S/c14-7-10-8-16-13(21-10)19-11-6-12(18-9-17-11)20-4-1-2-15-3-5-20/h6,8-9,15H,1-5H2,(H,16,17,18,19) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 27 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description Inhibition of KDR |
Bioorg Med Chem Lett 16: 1146-50 (2006)
Article DOI: 10.1016/j.bmcl.2005.11.089 BindingDB Entry DOI: 10.7270/Q279448N |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50179423
(2-(6-(1,4-diazepan-1-yl)pyrimidin-4-ylamino)thiazo...)Show InChI InChI=1S/C13H15N7S/c14-7-10-8-16-13(21-10)19-11-6-12(18-9-17-11)20-4-1-2-15-3-5-20/h6,8-9,15H,1-5H2,(H,16,17,18,19) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 32 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description Inhibition of human KDR expressed in HEK293 cells by KDR autophosphorylation assay |
Bioorg Med Chem Lett 16: 1146-50 (2006)
Article DOI: 10.1016/j.bmcl.2005.11.089 BindingDB Entry DOI: 10.7270/Q279448N |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50179422
(2-(6-(piperazin-1-yl)pyrimidin-4-ylamino)thiazole-...)Show InChI InChI=1S/C12H13N7S/c13-6-9-7-15-12(20-9)18-10-5-11(17-8-16-10)19-3-1-14-2-4-19/h5,7-8,14H,1-4H2,(H,15,16,17,18) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 34 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description Inhibition of human KDR expressed in HEK293 cells by KDR autophosphorylation assay |
Bioorg Med Chem Lett 16: 1146-50 (2006)
Article DOI: 10.1016/j.bmcl.2005.11.089 BindingDB Entry DOI: 10.7270/Q279448N |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM5354
(N-(5-chloropyridin-2-yl)-5-phenyl-1,3-thiazol-2-am...)Show InChI InChI=1S/C14H10ClN3S/c15-11-6-7-13(16-8-11)18-14-17-9-12(19-14)10-4-2-1-3-5-10/h1-9H,(H,16,17,18) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 35 | n/a | n/a | n/a | n/a | 7.4 | 22 |
Merck Research Laboratories
| Assay Description Activated KDR was incubated with 25 uM/10 uCi of [gamma-33P] ATP, poly-Glu/Tyr, and inhibitors in kinase buffer for 15 min at 22 °C. The reactio... |
Bioorg Med Chem Lett 14: 2941-5 (2004)
Article DOI: 10.1016/j.bmcl.2004.03.052 BindingDB Entry DOI: 10.7270/Q25H7DG7 |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM5362
(2-(pyridin-2-ylamino)-1,3-thiazole-5-carbonitrile ...)Show InChI InChI=1S/C9H6N4S/c10-5-7-6-12-9(14-7)13-8-3-1-2-4-11-8/h1-4,6H,(H,11,12,13) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 36 | n/a | n/a | n/a | n/a | 7.4 | 22 |
Merck Research Laboratories
| Assay Description Activated KDR was incubated with 25 uM/10 uCi of [gamma-33P] ATP, poly-Glu/Tyr, and inhibitors in kinase buffer for 15 min at 22 °C. The reactio... |
Bioorg Med Chem Lett 14: 2941-5 (2004)
Article DOI: 10.1016/j.bmcl.2004.03.052 BindingDB Entry DOI: 10.7270/Q25H7DG7 |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM5369
(5-(1-phenyl-1H-1,3-benzodiazol-5-yl)-1-[3-(piperid...)Show SMILES O=c1ccc(cn1CCCN1CCCCC1)-c1ccc2n(cnc2c1)-c1ccccc1 Show InChI InChI=1S/C26H28N4O/c31-26-13-11-22(19-29(26)17-7-16-28-14-5-2-6-15-28)21-10-12-25-24(18-21)27-20-30(25)23-8-3-1-4-9-23/h1,3-4,8-13,18-20H,2,5-7,14-17H2 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 37 | n/a | n/a | n/a | n/a | 7.4 | 22 |
Merck Research Laboratories
| Assay Description Activated KDR was incubated with 25 uM/10 uCi of [gamma-33P] ATP, poly-Glu/Tyr, and inhibitors in kinase buffer for 15 min at 22 °C. The reactio... |
Bioorg Med Chem Lett 13: 2485-8 (2003)
Article DOI: 10.1016/s0960-894x(03)00485-2 BindingDB Entry DOI: 10.7270/Q21R6NQ2 |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM5376
(1-[2-(4-{3-phenyl-3H-imidazo[4,5-b]pyridin-6-yl}ph...)Show SMILES C(CN1CCCCC1)Oc1ccc(cc1)-c1cnc2n(cnc2c1)-c1ccccc1 Show InChI InChI=1S/C25H26N4O/c1-3-7-22(8-4-1)29-19-27-24-17-21(18-26-25(24)29)20-9-11-23(12-10-20)30-16-15-28-13-5-2-6-14-28/h1,3-4,7-12,17-19H,2,5-6,13-16H2 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Patents
| Article PubMed
| n/a | n/a | 37 | n/a | n/a | n/a | n/a | 7.4 | 22 |
Merck Research Laboratories
| Assay Description Activated KDR was incubated with 25 uM/10 uCi of [gamma-33P] ATP, poly-Glu/Tyr, and inhibitors in kinase buffer for 15 min at 22 °C. The reactio... |
Bioorg Med Chem Lett 13: 2485-8 (2003)
Article DOI: 10.1016/s0960-894x(03)00485-2 BindingDB Entry DOI: 10.7270/Q21R6NQ2 |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50179425
(2-(6-aminopyrimidin-4-ylamino)thiazole-5-carbonitr...)Show InChI InChI=1S/C8H6N6S/c9-2-5-3-11-8(15-5)14-7-1-6(10)12-4-13-7/h1,3-4H,(H3,10,11,12,13,14) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 41 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description Inhibition of KDR |
Bioorg Med Chem Lett 16: 1146-50 (2006)
Article DOI: 10.1016/j.bmcl.2005.11.089 BindingDB Entry DOI: 10.7270/Q279448N |
More data for this Ligand-Target Pair | |