Compile Data Set for Download or QSAR

Found 395 hits with Last Name = 'lawson' and Initial = 'c'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Delta-type opioid receptor/Kappa-type opioid receptor/Mu-type opioid receptor/Sigma non-opioid intracellular receptor 1 (Rattus norvegicus (rat)-RAT)	BDBM50001119 (8-(4-Oxo-1-phenyl-1,3,8-triaza-spiro[4.5]dec-8-ylm...) Show SMILES O=C1NCN(c2ccccc2)C11CCN(CC2COc3ccc4[nH]c(cc4c3O2)C#N)CC1 Show InChI InChI=1S/C25H25N5O3/c26-13-17-12-20-21(28-17)6-7-22-23(20)33-19(15-32-22)14-29-10-8-25(9-11-29)24(31)27-16-30(25)18-4-2-1-3-5-18/h1-7,12,19,28H,8-11,14-16H2,(H,27,31)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	0.100	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Upjohn Company Curated by ChEMBL					Assay Description Compound was evaluated for the binding affinity towards opioid receptor from rat whole brain using [3H]etorpine (33.2 Ci/mmol,0.2nanoM)as radioligand				J Med Chem 35: 3058-66 (1992) BindingDB Entry DOI: 10.7270/Q21835G5
					More data for this Ligand-Target Pair
Urotensin-2 receptor (RAT)	BDBM50302273 ((4R,7S,10S,13S,16S,19R)-13-((1H-indol-3-yl)methyl)...) Show SMILES CC(=O)N[C@H]1CSSC[C@H](NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2ccccc2)NC1=O)C(N)=O |r| Show InChI InChI=1S/C47H55N9O7S2/c1-28(57)51-41-27-65-64-26-40(42(49)58)56-45(61)38(23-30-18-19-31-13-5-6-14-32(31)21-30)53-43(59)36(17-9-10-20-48)52-46(62)39(24-33-25-50-35-16-8-7-15-34(33)35)55-44(60)37(54-47(41)63)22-29-11-3-2-4-12-29/h2-8,11-16,18-19,21,25,36-41,50H,9-10,17,20,22-24,26-27,48H2,1H3,(H2,49,58)(H,51,57)(H,52,62)(H,53,59)(H,54,63)(H,55,60)(H,56,61)/t36-,37-,38-,39-,40-,41-/m0/s1	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	0.120	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Johnson& Johnson Pharmaceutical Research& Development Curated by ChEMBL					Assay Description Displacement of [125I]urotensin 2 from rat urotensin 2 receptor expressed in CHOK1 cells by scintillation proximity assay				J Med Chem 52: 7432-45 (2009) Article DOI: 10.1021/jm900683d BindingDB Entry DOI: 10.7270/Q2S75GD7
					More data for this Ligand-Target Pair
D(2) dopamine receptor (Homo sapiens (Human))	BDBM50001118 (8-(7,8-Dihydro-3H-6,9-dioxa-3-aza-cyclopenta[a]nap...) Show SMILES O=C1NCN(c2ccccc2)C11CCN(CC2COc3ccc4[nH]ccc4c3O2)CC1 Show InChI InChI=1S/C24H26N4O3/c29-23-24(28(16-26-23)17-4-2-1-3-5-17)9-12-27(13-10-24)14-18-15-30-21-7-6-20-19(8-11-25-20)22(21)31-18/h1-8,11,18,25H,9-10,12-16H2,(H,26,29)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	0.200	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Upjohn Company Curated by ChEMBL					Assay Description Compound was evaluated for the binding affinity towards Dopamine receptor D2 from mammalian clones expressed in CHO cell membranes using 2 (86.1 Ci/m...				J Med Chem 35: 3058-66 (1992) BindingDB Entry DOI: 10.7270/Q21835G5
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 1A (Homo sapiens (Human))	BDBM50001117 (8-[(3-Phenyl-propylamino)-methyl]-7,8-dihydro-3H-6...) Show SMILES COC(=O)c1cc2c3OC(CNCCCc4ccccc4)COc3ccc2[nH]1 Show InChI InChI=1S/C22H24N2O4/c1-26-22(25)19-12-17-18(24-19)9-10-20-21(17)28-16(14-27-20)13-23-11-5-8-15-6-3-2-4-7-15/h2-4,6-7,9-10,12,16,23-24H,5,8,11,13-14H2,1H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	0.200	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Upjohn Company Curated by ChEMBL					Assay Description Displacement of [3H]-8-OH-DPAT from 5-hydroxytryptamine 1A receptor expressed in CHO cell membranes				J Med Chem 35: 3058-66 (1992) BindingDB Entry DOI: 10.7270/Q21835G5
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 1A (Homo sapiens (Human))	BDBM50001113 (8-(4-Oxo-1-phenyl-1,3,8-triaza-spiro[4.5]dec-8-ylm...) Show SMILES NC(=O)c1cc2c3OC(CN4CCC5(CC4)N(CNC5=O)c4ccccc4)COc3ccc2[nH]1 Show InChI InChI=1S/C25H27N5O4/c26-23(31)20-12-18-19(28-20)6-7-21-22(18)34-17(14-33-21)13-29-10-8-25(9-11-29)24(32)27-15-30(25)16-4-2-1-3-5-16/h1-7,12,17,28H,8-11,13-15H2,(H2,26,31)(H,27,32)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	0.300	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Upjohn Company Curated by ChEMBL					Assay Description Displacement of [3H]-8-OH-DPAT from 5-hydroxytryptamine 1A receptor expressed in CHO cell membranes				J Med Chem 35: 3058-66 (1992) BindingDB Entry DOI: 10.7270/Q21835G5
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 1A (Homo sapiens (Human))	BDBM50001118 (8-(7,8-Dihydro-3H-6,9-dioxa-3-aza-cyclopenta[a]nap...) Show SMILES O=C1NCN(c2ccccc2)C11CCN(CC2COc3ccc4[nH]ccc4c3O2)CC1 Show InChI InChI=1S/C24H26N4O3/c29-23-24(28(16-26-23)17-4-2-1-3-5-17)9-12-27(13-10-24)14-18-15-30-21-7-6-20-19(8-11-25-20)22(21)31-18/h1-8,11,18,25H,9-10,12-16H2,(H,26,29)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	0.400	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Upjohn Company Curated by ChEMBL					Assay Description Displacement of [3H]-8-OH-DPAT from 5-hydroxytryptamine 1A receptor expressed in CHO cell membranes				J Med Chem 35: 3058-66 (1992) BindingDB Entry DOI: 10.7270/Q21835G5
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 1A (Homo sapiens (Human))	BDBM50001119 (8-(4-Oxo-1-phenyl-1,3,8-triaza-spiro[4.5]dec-8-ylm...) Show SMILES O=C1NCN(c2ccccc2)C11CCN(CC2COc3ccc4[nH]c(cc4c3O2)C#N)CC1 Show InChI InChI=1S/C25H25N5O3/c26-13-17-12-20-21(28-17)6-7-22-23(20)33-19(15-32-22)14-29-10-8-25(9-11-29)24(31)27-16-30(25)18-4-2-1-3-5-18/h1-7,12,19,28H,8-11,14-16H2,(H,27,31)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	0.5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Upjohn Company Curated by ChEMBL					Assay Description Displacement of [3H]-8-OH-DPAT from 5-hydroxytryptamine 1A receptor expressed in CHO cell membranes				J Med Chem 35: 3058-66 (1992) BindingDB Entry DOI: 10.7270/Q21835G5
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 1A (Homo sapiens (Human))	BDBM50001112 (8-(2-Hydroxymethyl-7,8-dihydro-3H-6,9-dioxa-3-aza-...) Show SMILES OCc1cc2c3OC(CN4CCC5(CC4)N(CNC5=O)c4ccccc4)COc3ccc2[nH]1 Show InChI InChI=1S/C25H28N4O4/c30-14-17-12-20-21(27-17)6-7-22-23(20)33-19(15-32-22)13-28-10-8-25(9-11-28)24(31)26-16-29(25)18-4-2-1-3-5-18/h1-7,12,19,27,30H,8-11,13-16H2,(H,26,31)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	0.600	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Upjohn Company Curated by ChEMBL					Assay Description Displacement of [3H]-8-OH-DPAT from 5-hydroxytryptamine 1A receptor expressed in CHO cell membranes				J Med Chem 35: 3058-66 (1992) BindingDB Entry DOI: 10.7270/Q21835G5
					More data for this Ligand-Target Pair
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor (Rattus norvegicus (rat)-Rattus norvegicus (Rat))	BDBM50001117 (8-[(3-Phenyl-propylamino)-methyl]-7,8-dihydro-3H-6...) Show SMILES COC(=O)c1cc2c3OC(CNCCCc4ccccc4)COc3ccc2[nH]1 Show InChI InChI=1S/C22H24N2O4/c1-26-22(25)19-12-17-18(24-19)9-10-20-21(17)28-16(14-27-20)13-23-11-5-8-15-6-3-2-4-7-15/h2-4,6-7,9-10,12,16,23-24H,5,8,11,13-14H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	0.600	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Upjohn Company Curated by ChEMBL					Assay Description Binding affinity towards Alpha-1 adrenergic receptor from rat whole brain using [3H]prazosin (18.1 Ci/mmol,0.9nanoM)as radioligand				J Med Chem 35: 3058-66 (1992) BindingDB Entry DOI: 10.7270/Q21835G5
					More data for this Ligand-Target Pair
Delta-type opioid receptor/Kappa-type opioid receptor/Mu-type opioid receptor/Sigma non-opioid intracellular receptor 1 (Rattus norvegicus (rat)-RAT)	BDBM50001113 (8-(4-Oxo-1-phenyl-1,3,8-triaza-spiro[4.5]dec-8-ylm...) Show SMILES NC(=O)c1cc2c3OC(CN4CCC5(CC4)N(CNC5=O)c4ccccc4)COc3ccc2[nH]1 Show InChI InChI=1S/C25H27N5O4/c26-23(31)20-12-18-19(28-20)6-7-21-22(18)34-17(14-33-21)13-29-10-8-25(9-11-29)24(32)27-15-30(25)16-4-2-1-3-5-16/h1-7,12,17,28H,8-11,13-15H2,(H2,26,31)(H,27,32)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	0.600	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Upjohn Company Curated by ChEMBL					Assay Description Compound was evaluated for the binding affinity towards opioid receptor from rat whole brain using [3H]etorpine (33.2 Ci/mmol,0.2nanoM)as radioligand				J Med Chem 35: 3058-66 (1992) BindingDB Entry DOI: 10.7270/Q21835G5
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 1A (Homo sapiens (Human))	BDBM50001116 (8-[4-(2-Oxo-2,3-dihydro-benzoimidazol-1-yl)-piperi...) Show SMILES COC(=O)c1cc2c3OC(CN4CCC(CC4)n4c5ccccc5[nH]c4=O)COc3ccc2[nH]1 Show InChI InChI=1S/C25H26N4O5/c1-32-24(30)20-12-17-18(26-20)6-7-22-23(17)34-16(14-33-22)13-28-10-8-15(9-11-28)29-21-5-3-2-4-19(21)27-25(29)31/h2-7,12,15-16,26H,8-11,13-14H2,1H3,(H,27,31)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	PubMed	0.600	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Upjohn Company Curated by ChEMBL					Assay Description Displacement of [3H]-8-OH-DPAT from 5-hydroxytryptamine 1A receptor expressed in CHO cell membranes				J Med Chem 35: 3058-66 (1992) BindingDB Entry DOI: 10.7270/Q21835G5
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 1D (Homo sapiens (Human))	BDBM50064786 ((S)-1-(2-(4-(4-methoxyphenyl)piperazin-1-yl)ethyl)...) Show SMILES CNC(=O)c1ccc2[C@H](CCN3CCN(CC3)c3ccc(OC)cc3)OCCc2c1 |r| Show InChI InChI=1S/C24H31N3O3/c1-25-24(28)19-3-8-22-18(17-19)10-16-30-23(22)9-11-26-12-14-27(15-13-26)20-4-6-21(29-2)7-5-20/h3-8,17,23H,9-16H2,1-2H3,(H,25,28)/t23-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	0.900	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Pharmacia & Upjohn Curated by ChEMBL					Assay Description The compound was tested for CNS binding affinity towards 5-hydroxytryptamine 1D receptor from cloned gorilla membranes expressed in cultured HEK 293 ...				J Med Chem 41: 2180-3 (1998) Article DOI: 10.1021/jm980137o BindingDB Entry DOI: 10.7270/Q2NV9HCP
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 1A (Homo sapiens (Human))	BDBM50001114 (8-(4-Oxo-1-phenyl-1,3,8-triaza-spiro[4.5]dec-8-ylm...) Show SMILES COC(=O)c1cc2c3OC(CN4CCC5(CC4)N(CNC5=O)c4ccccc4)COc3ccc2[nH]1 Show InChI InChI=1S/C26H28N4O5/c1-33-24(31)21-13-19-20(28-21)7-8-22-23(19)35-18(15-34-22)14-29-11-9-26(10-12-29)25(32)27-16-30(26)17-5-3-2-4-6-17/h2-8,13,18,28H,9-12,14-16H2,1H3,(H,27,32)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	0.900	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Upjohn Company Curated by ChEMBL					Assay Description Displacement of [3H]-8-OH-DPAT from 5-hydroxytryptamine 1A receptor expressed in CHO cell membranes				J Med Chem 35: 3058-66 (1992) BindingDB Entry DOI: 10.7270/Q21835G5
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 1A (Homo sapiens (Human))	BDBM50001110 (8-(4-Oxo-1-phenyl-1,3,8-triaza-spiro[4.5]dec-8-ylm...) Show SMILES O=C(OCc1ccccc1)c1cc2c3OC(CN4CCC5(CC4)N(CNC5=O)c4ccccc4)COc3ccc2[nH]1 Show InChI InChI=1S/C32H32N4O5/c37-30(40-19-22-7-3-1-4-8-22)27-17-25-26(34-27)11-12-28-29(25)41-24(20-39-28)18-35-15-13-32(14-16-35)31(38)33-21-36(32)23-9-5-2-6-10-23/h1-12,17,24,34H,13-16,18-21H2,(H,33,38)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	1	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Upjohn Company Curated by ChEMBL					Assay Description Displacement of [3H]-8-OH-DPAT from 5-hydroxytryptamine 1A receptor expressed in CHO cell membranes				J Med Chem 35: 3058-66 (1992) BindingDB Entry DOI: 10.7270/Q21835G5
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 1A (Homo sapiens (Human))	BDBM50001111 (8-(4-Ethoxycarbonyl-piperidin-1-ylmethyl)-7,8-dihy...) Show SMILES CCOC(=O)C1CCN(CC2COc3ccc4[nH]c(cc4c3O2)C(=O)OC)CC1 Show InChI InChI=1S/C21H26N2O6/c1-3-27-20(24)13-6-8-23(9-7-13)11-14-12-28-18-5-4-16-15(19(18)29-14)10-17(22-16)21(25)26-2/h4-5,10,13-14,22H,3,6-9,11-12H2,1-2H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	1.20	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Upjohn Company Curated by ChEMBL					Assay Description Displacement of [3H]-8-OH-DPAT from 5-hydroxytryptamine 1A receptor expressed in CHO cell membranes				J Med Chem 35: 3058-66 (1992) BindingDB Entry DOI: 10.7270/Q21835G5
					More data for this Ligand-Target Pair
D(4) dopamine receptor (RAT)	BDBM50051562 (1-(2-Isochroman-1-yl-ethyl)-4-(4-methoxy-phenyl)-p...) Show SMILES COc1ccc(cc1)N1CCN(CCC2OCCc3ccccc23)CC1 Show InChI InChI=1S/C22H28N2O2/c1-25-20-8-6-19(7-9-20)24-15-13-23(14-16-24)12-10-22-21-5-3-2-4-18(21)11-17-26-22/h2-9,22H,10-17H2,1H3	Reactome pathway UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	1.40	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Pharmacia & Upjohn Curated by ChEMBL					Assay Description Binding affinity of [3H]-Spiperone towards Dopamine receptor D4 expressed in cultured cells or from rat whole brain.				J Med Chem 39: 2435-7 (1996) Article DOI: 10.1021/jm960084f BindingDB Entry DOI: 10.7270/Q2H1314Z
					More data for this Ligand-Target Pair
D(2) dopamine receptor (Homo sapiens (Human))	BDBM50001119 (8-(4-Oxo-1-phenyl-1,3,8-triaza-spiro[4.5]dec-8-ylm...) Show SMILES O=C1NCN(c2ccccc2)C11CCN(CC2COc3ccc4[nH]c(cc4c3O2)C#N)CC1 Show InChI InChI=1S/C25H25N5O3/c26-13-17-12-20-21(28-17)6-7-22-23(20)33-19(15-32-22)14-29-10-8-25(9-11-29)24(31)27-16-30(25)18-4-2-1-3-5-18/h1-7,12,19,28H,8-11,14-16H2,(H,27,31)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	1.5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Upjohn Company Curated by ChEMBL					Assay Description Binding affinity towards Dopamine receptor D2 from mammalian clones expressed in CHO cell membranes using 2 (86.1 Ci/mmol,1.7nanoM)as radioligand				J Med Chem 35: 3058-66 (1992) BindingDB Entry DOI: 10.7270/Q21835G5
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 1A (Homo sapiens (Human))	BDBM50001115 (8-[(3-Phenyl-propylamino)-methyl]-7,8-dihydro-3H-6...) Show SMILES O=C(NCCCc1ccccc1)c1cc2c3OC(CNCCCc4ccccc4)COc3ccc2[nH]1 Show InChI InChI=1S/C30H33N3O3/c34-30(32-18-8-14-23-11-5-2-6-12-23)27-19-25-26(33-27)15-16-28-29(25)36-24(21-35-28)20-31-17-7-13-22-9-3-1-4-10-22/h1-6,9-12,15-16,19,24,31,33H,7-8,13-14,17-18,20-21H2,(H,32,34)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents	PubMed	1.60	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Upjohn Company Curated by ChEMBL					Assay Description Displacement of [3H]-8-OH-DPAT from 5-hydroxytryptamine 1A receptor expressed in CHO cell membranes				J Med Chem 35: 3058-66 (1992) BindingDB Entry DOI: 10.7270/Q21835G5
					More data for this Ligand-Target Pair
D(2) dopamine receptor (Homo sapiens (Human))	BDBM50001113 (8-(4-Oxo-1-phenyl-1,3,8-triaza-spiro[4.5]dec-8-ylm...) Show SMILES NC(=O)c1cc2c3OC(CN4CCC5(CC4)N(CNC5=O)c4ccccc4)COc3ccc2[nH]1 Show InChI InChI=1S/C25H27N5O4/c26-23(31)20-12-18-19(28-20)6-7-21-22(18)34-17(14-33-21)13-29-10-8-25(9-11-29)24(32)27-15-30(25)16-4-2-1-3-5-16/h1-7,12,17,28H,8-11,13-15H2,(H2,26,31)(H,27,32)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	1.80	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Upjohn Company Curated by ChEMBL					Assay Description Binding affinity towards Dopamine receptor D2 from mammalian clones expressed in CHO cell membranes using 2 (86.1 Ci/mmol,1.7nanoM)as radioligand				J Med Chem 35: 3058-66 (1992) BindingDB Entry DOI: 10.7270/Q21835G5
					More data for this Ligand-Target Pair
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor (Rattus norvegicus (rat)-Rattus norvegicus (Rat))	BDBM50001116 (8-[4-(2-Oxo-2,3-dihydro-benzoimidazol-1-yl)-piperi...) Show SMILES COC(=O)c1cc2c3OC(CN4CCC(CC4)n4c5ccccc5[nH]c4=O)COc3ccc2[nH]1 Show InChI InChI=1S/C25H26N4O5/c1-32-24(30)20-12-17-18(26-20)6-7-22-23(17)34-16(14-33-22)13-28-10-8-15(9-11-28)29-21-5-3-2-4-19(21)27-25(29)31/h2-7,12,15-16,26H,8-11,13-14H2,1H3,(H,27,31)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	PubMed	1.80	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Upjohn Company Curated by ChEMBL					Assay Description Binding affinity towards Alpha-1 adrenergic receptor from rat whole brain using [3H]prazosin (18.1 Ci/mmol,0.9nanoM)as radioligand				J Med Chem 35: 3058-66 (1992) BindingDB Entry DOI: 10.7270/Q21835G5
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 1D (Homo sapiens (Human))	BDBM50005835 ((3-[2-(dimethylamino)ethyl]-1H-indol-5-yl)-N-methy...) Show SMILES CNS(=O)(=O)Cc1ccc2[nH]cc(CCN(C)C)c2c1 Show InChI InChI=1S/C14H21N3O2S/c1-15-20(18,19)10-11-4-5-14-13(8-11)12(9-16-14)6-7-17(2)3/h4-5,8-9,15-16H,6-7,10H2,1-3H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid UniChem Patents	DrugBank Article PubMed	2	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Pharmacia & Upjohn Curated by ChEMBL					Assay Description The compound was tested for CNS binding affinity towards 5-hydroxytryptamine 1D receptor from cloned gorilla membranes expressed in cultured HEK 293 ...				J Med Chem 41: 2180-3 (1998) Article DOI: 10.1021/jm980137o BindingDB Entry DOI: 10.7270/Q2NV9HCP
					More data for this Ligand-Target Pair
D(2) dopamine receptor (Homo sapiens (Human))	BDBM50001112 (8-(2-Hydroxymethyl-7,8-dihydro-3H-6,9-dioxa-3-aza-...) Show SMILES OCc1cc2c3OC(CN4CCC5(CC4)N(CNC5=O)c4ccccc4)COc3ccc2[nH]1 Show InChI InChI=1S/C25H28N4O4/c30-14-17-12-20-21(27-17)6-7-22-23(20)33-19(15-32-22)13-28-10-8-25(9-11-28)24(31)26-16-29(25)18-4-2-1-3-5-18/h1-7,12,19,27,30H,8-11,13-16H2,(H,26,31)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	2	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Upjohn Company Curated by ChEMBL					Assay Description Binding affinity towards Dopamine receptor D2 from mammalian clones expressed in CHO cell membranes using 2 (86.1 Ci/mmol,1.7nanoM)as radioligand				J Med Chem 35: 3058-66 (1992) BindingDB Entry DOI: 10.7270/Q21835G5
					More data for this Ligand-Target Pair
D(4) dopamine receptor (RAT)	BDBM50051561 (1-((S)-2-Isochroman-1-yl-ethyl)-4-(4-methoxy-pheny...) Show SMILES COc1ccc(cc1)N1CCN(CC[C@@H]2OCCc3ccccc23)CC1 Show InChI InChI=1S/C22H28N2O2/c1-25-20-8-6-19(7-9-20)24-15-13-23(14-16-24)12-10-22-21-5-3-2-4-18(21)11-17-26-22/h2-9,22H,10-17H2,1H3/t22-/m0/s1	Reactome pathway UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	2.20	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Pharmacia & Upjohn Curated by ChEMBL					Assay Description Binding affinity of [3H]-Spiperone towards Dopamine receptor D4 expressed in cultured cells or from rat whole brain.				J Med Chem 39: 2435-7 (1996) Article DOI: 10.1021/jm960084f BindingDB Entry DOI: 10.7270/Q2H1314Z
					More data for this Ligand-Target Pair
D(4) dopamine receptor (Homo sapiens (Human))	BDBM50051562 (1-(2-Isochroman-1-yl-ethyl)-4-(4-methoxy-phenyl)-p...) Show SMILES COc1ccc(cc1)N1CCN(CCC2OCCc3ccccc23)CC1 Show InChI InChI=1S/C22H28N2O2/c1-25-20-8-6-19(7-9-20)24-15-13-23(14-16-24)12-10-22-21-5-3-2-4-18(21)11-17-26-22/h2-9,22H,10-17H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	2.40	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Pharmacia & Upjohn Curated by ChEMBL					Assay Description The compound was tested for CNS binding affinity towards Dopamine receptor D4 from cloned Human membranes.				J Med Chem 41: 2180-3 (1998) Article DOI: 10.1021/jm980137o BindingDB Entry DOI: 10.7270/Q2NV9HCP
					More data for this Ligand-Target Pair
D(4) dopamine receptor (RAT)	BDBM85067 (CAS_170856-41-4 | CHEMBL81330 | PNU 96415E | PNU-9...) Show SMILES Fc1ccc(cc1)N1CCN(CCC2OCCc3ccccc23)CC1 Show InChI InChI=1S/C21H25FN2O/c22-18-5-7-19(8-6-18)24-14-12-23(13-15-24)11-9-21-20-4-2-1-3-17(20)10-16-25-21/h1-8,21H,9-16H2	Reactome pathway UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Pharmacia & Upjohn Curated by ChEMBL					Assay Description Binding affinity of [3H]-Spiperone towards Dopamine receptor D4 expressed in cultured cells or from rat whole brain.				J Med Chem 39: 2435-7 (1996) Article DOI: 10.1021/jm960084f BindingDB Entry DOI: 10.7270/Q2H1314Z
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 1A (Homo sapiens (Human))	BDBM50001109 (8-(4-Oxo-1-phenyl-1,3,8-triaza-spiro[4.5]dec-8-ylm...) Show SMILES CCCCOC(=O)c1cc2c3OC(CN4CCC5(CC4)N(CNC5=O)c4ccccc4)COc3ccc2[nH]1 Show InChI InChI=1S/C29H34N4O5/c1-2-3-15-36-27(34)24-16-22-23(31-24)9-10-25-26(22)38-21(18-37-25)17-32-13-11-29(12-14-32)28(35)30-19-33(29)20-7-5-4-6-8-20/h4-10,16,21,31H,2-3,11-15,17-19H2,1H3,(H,30,35)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Upjohn Company Curated by ChEMBL					Assay Description Displacement of [3H]-8-OH-DPAT from 5-hydroxytryptamine 1A receptor expressed in CHO cell membranes				J Med Chem 35: 3058-66 (1992) BindingDB Entry DOI: 10.7270/Q21835G5
					More data for this Ligand-Target Pair
Delta-type opioid receptor/Kappa-type opioid receptor/Mu-type opioid receptor/Sigma non-opioid intracellular receptor 1 (Rattus norvegicus (rat)-RAT)	BDBM50001109 (8-(4-Oxo-1-phenyl-1,3,8-triaza-spiro[4.5]dec-8-ylm...) Show SMILES CCCCOC(=O)c1cc2c3OC(CN4CCC5(CC4)N(CNC5=O)c4ccccc4)COc3ccc2[nH]1 Show InChI InChI=1S/C29H34N4O5/c1-2-3-15-36-27(34)24-16-22-23(31-24)9-10-25-26(22)38-21(18-37-25)17-32-13-11-29(12-14-32)28(35)30-19-33(29)20-7-5-4-6-8-20/h4-10,16,21,31H,2-3,11-15,17-19H2,1H3,(H,30,35)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	3.10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Upjohn Company Curated by ChEMBL					Assay Description Compound was evaluated for the binding affinity towards opioid receptor from rat whole brain using [3H]etorpine (33.2 Ci/mmol,0.2nanoM)as radioligand				J Med Chem 35: 3058-66 (1992) BindingDB Entry DOI: 10.7270/Q21835G5
					More data for this Ligand-Target Pair
D(2) dopamine receptor (Homo sapiens (Human))	BDBM50001114 (8-(4-Oxo-1-phenyl-1,3,8-triaza-spiro[4.5]dec-8-ylm...) Show SMILES COC(=O)c1cc2c3OC(CN4CCC5(CC4)N(CNC5=O)c4ccccc4)COc3ccc2[nH]1 Show InChI InChI=1S/C26H28N4O5/c1-33-24(31)21-13-19-20(28-21)7-8-22-23(19)35-18(15-34-22)14-29-11-9-26(10-12-29)25(32)27-16-30(26)17-5-3-2-4-6-17/h2-8,13,18,28H,9-12,14-16H2,1H3,(H,27,32)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	3.10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Upjohn Company Curated by ChEMBL					Assay Description Compound was evaluated for the binding affinity towards Dopamine receptor D2 from mammalian clones expressed in CHO cell membranes using [3H]-U-86,17...				J Med Chem 35: 3058-66 (1992) BindingDB Entry DOI: 10.7270/Q21835G5
					More data for this Ligand-Target Pair
Delta-type opioid receptor/Kappa-type opioid receptor/Mu-type opioid receptor/Sigma non-opioid intracellular receptor 1 (Rattus norvegicus (rat)-RAT)	BDBM50001112 (8-(2-Hydroxymethyl-7,8-dihydro-3H-6,9-dioxa-3-aza-...) Show SMILES OCc1cc2c3OC(CN4CCC5(CC4)N(CNC5=O)c4ccccc4)COc3ccc2[nH]1 Show InChI InChI=1S/C25H28N4O4/c30-14-17-12-20-21(27-17)6-7-22-23(20)33-19(15-32-22)13-28-10-8-25(9-11-28)24(31)26-16-29(25)18-4-2-1-3-5-18/h1-7,12,19,27,30H,8-11,13-16H2,(H,26,31)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	3.30	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Upjohn Company Curated by ChEMBL					Assay Description Inhibition of human erythrocyte carbonic anhydrase II				J Med Chem 35: 3058-66 (1992) BindingDB Entry DOI: 10.7270/Q21835G5
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 1D (Homo sapiens (Human))	BDBM50064784 ((S)-1-{2-[4-(4-Methoxy-phenyl)-piperazin-1-yl]-eth...) Show SMILES COc1ccc(cc1)N1CCN(CC[C@@H]2OCCc3cc(ccc23)C(N)=O)CC1 Show InChI InChI=1S/C23H29N3O3/c1-28-20-5-3-19(4-6-20)26-13-11-25(12-14-26)10-8-22-21-7-2-18(23(24)27)16-17(21)9-15-29-22/h2-7,16,22H,8-15H2,1H3,(H2,24,27)/t22-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	3.80	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Pharmacia & Upjohn Curated by ChEMBL					Assay Description The compound was tested for CNS binding affinity towards 5-hydroxytryptamine 1D receptor from cloned gorilla membranes expressed in cultured HEK 293 ...				J Med Chem 41: 2180-3 (1998) Article DOI: 10.1021/jm980137o BindingDB Entry DOI: 10.7270/Q2NV9HCP
					More data for this Ligand-Target Pair
Urotensin-2 receptor (Homo sapiens (Human))	BDBM50302257 ((R)-N-(4-(3,4-dimethoxyphenyl)-4-(4-(4-ethylpipera...) Show SMILES CCN1CCN(CC1)c1cccc2C(=O)N(Cc12)[C@H](CCCNS(=O)(=O)c1cccs1)c1ccc(OC)c(OC)c1 |r| Show InChI InChI=1S/C30H38N4O5S2/c1-4-32-15-17-33(18-16-32)26-9-5-8-23-24(26)21-34(30(23)35)25(22-12-13-27(38-2)28(20-22)39-3)10-6-14-31-41(36,37)29-11-7-19-40-29/h5,7-9,11-13,19-20,25,31H,4,6,10,14-18,21H2,1-3H3/t25-/m1/s1	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Johnson& Johnson Pharmaceutical Research& Development Curated by ChEMBL					Assay Description Displacement of [125I]urotensin 2 from urotensin 2 receptor in human RMS13 cells by scintillation proximity assay				J Med Chem 52: 7432-45 (2009) Article DOI: 10.1021/jm900683d BindingDB Entry DOI: 10.7270/Q2S75GD7
					More data for this Ligand-Target Pair
Urotensin-2 receptor (Homo sapiens (Human))	BDBM50302258 ((R)-N-(4-(3,4-dimethoxyphenyl)-4-(4-(4-isopropylpi...) Show SMILES COc1ccc(cc1OC)[C@@H](CCCNS(=O)(=O)c1cccs1)N1Cc2c(cccc2N2CCN(CC2)C(C)C)C1=O |r| Show InChI InChI=1S/C31H40N4O5S2/c1-22(2)33-15-17-34(18-16-33)27-9-5-8-24-25(27)21-35(31(24)36)26(23-12-13-28(39-3)29(20-23)40-4)10-6-14-32-42(37,38)30-11-7-19-41-30/h5,7-9,11-13,19-20,22,26,32H,6,10,14-18,21H2,1-4H3/t26-/m1/s1	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Johnson& Johnson Pharmaceutical Research& Development Curated by ChEMBL					Assay Description Displacement of [125I]urotensin 2 from urotensin 2 receptor in human RMS13 cells by scintillation proximity assay				J Med Chem 52: 7432-45 (2009) Article DOI: 10.1021/jm900683d BindingDB Entry DOI: 10.7270/Q2S75GD7
					More data for this Ligand-Target Pair
Delta-type opioid receptor/Kappa-type opioid receptor/Mu-type opioid receptor/Sigma non-opioid intracellular receptor 1 (Rattus norvegicus (rat)-RAT)	BDBM50001116 (8-[4-(2-Oxo-2,3-dihydro-benzoimidazol-1-yl)-piperi...) Show SMILES COC(=O)c1cc2c3OC(CN4CCC(CC4)n4c5ccccc5[nH]c4=O)COc3ccc2[nH]1 Show InChI InChI=1S/C25H26N4O5/c1-32-24(30)20-12-17-18(26-20)6-7-22-23(17)34-16(14-33-22)13-28-10-8-15(9-11-28)29-21-5-3-2-4-19(21)27-25(29)31/h2-7,12,15-16,26H,8-11,13-14H2,1H3,(H,27,31)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	PubMed	4.30	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Upjohn Company Curated by ChEMBL					Assay Description Inhibition of human erythrocyte carbonic anhydrase II				J Med Chem 35: 3058-66 (1992) BindingDB Entry DOI: 10.7270/Q21835G5
					More data for this Ligand-Target Pair
D(2) dopamine receptor (Homo sapiens (Human))	BDBM50001109 (8-(4-Oxo-1-phenyl-1,3,8-triaza-spiro[4.5]dec-8-ylm...) Show SMILES CCCCOC(=O)c1cc2c3OC(CN4CCC5(CC4)N(CNC5=O)c4ccccc4)COc3ccc2[nH]1 Show InChI InChI=1S/C29H34N4O5/c1-2-3-15-36-27(34)24-16-22-23(31-24)9-10-25-26(22)38-21(18-37-25)17-32-13-11-29(12-14-32)28(35)30-19-33(29)20-7-5-4-6-8-20/h4-10,16,21,31H,2-3,11-15,17-19H2,1H3,(H,30,35)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	5.70	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Upjohn Company Curated by ChEMBL					Assay Description Binding affinity towards Dopamine receptor D2 from mammalian clones expressed in CHO cell membranes using 2 (86.1 Ci/mmol,1.7nanoM)as radioligand				J Med Chem 35: 3058-66 (1992) BindingDB Entry DOI: 10.7270/Q21835G5
					More data for this Ligand-Target Pair
D(2) dopamine receptor (Homo sapiens (Human))	BDBM50001110 (8-(4-Oxo-1-phenyl-1,3,8-triaza-spiro[4.5]dec-8-ylm...) Show SMILES O=C(OCc1ccccc1)c1cc2c3OC(CN4CCC5(CC4)N(CNC5=O)c4ccccc4)COc3ccc2[nH]1 Show InChI InChI=1S/C32H32N4O5/c37-30(40-19-22-7-3-1-4-8-22)27-17-25-26(34-27)11-12-28-29(25)41-24(20-39-28)18-35-15-13-32(14-16-35)31(38)33-21-36(32)23-9-5-2-6-10-23/h1-12,17,24,34H,13-16,18-21H2,(H,33,38)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	5.80	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Upjohn Company Curated by ChEMBL					Assay Description Binding affinity towards Dopamine receptor D2 from mammalian clones expressed in CHO cell membranes using 2 (86.1 Ci/mmol,1.7nanoM)as radioligand				J Med Chem 35: 3058-66 (1992) BindingDB Entry DOI: 10.7270/Q21835G5
					More data for this Ligand-Target Pair
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor (Rattus norvegicus (rat)-Rattus norvegicus (Rat))	BDBM50001119 (8-(4-Oxo-1-phenyl-1,3,8-triaza-spiro[4.5]dec-8-ylm...) Show SMILES O=C1NCN(c2ccccc2)C11CCN(CC2COc3ccc4[nH]c(cc4c3O2)C#N)CC1 Show InChI InChI=1S/C25H25N5O3/c26-13-17-12-20-21(28-17)6-7-22-23(20)33-19(15-32-22)14-29-10-8-25(9-11-29)24(31)27-16-30(25)18-4-2-1-3-5-18/h1-7,12,19,28H,8-11,14-16H2,(H,27,31)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	6	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Upjohn Company Curated by ChEMBL					Assay Description Binding affinity towards Alpha-1 adrenergic receptor from rat whole brain using [3H]prazosin (18.1 Ci/mmol,0.9nanoM)as radioligand				J Med Chem 35: 3058-66 (1992) BindingDB Entry DOI: 10.7270/Q21835G5
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 1B (Gorilla gorilla gorilla)	BDBM50005835 ((3-[2-(dimethylamino)ethyl]-1H-indol-5-yl)-N-methy...) Show SMILES CNS(=O)(=O)Cc1ccc2[nH]cc(CCN(C)C)c2c1 Show InChI InChI=1S/C14H21N3O2S/c1-15-20(18,19)10-11-4-5-14-13(8-11)12(9-16-14)6-7-17(2)3/h4-5,8-9,15-16H,6-7,10H2,1-3H3	PDB MMDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid UniChem Patents	Article PubMed	6.40	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Pharmacia & Upjohn Curated by ChEMBL					Assay Description The compound was tested for CNS binding affinity towards 5-hydroxytryptamine 1B receptor from cloned gorilla membranes expressed in cultured HEK 293 ...				J Med Chem 41: 2180-3 (1998) Article DOI: 10.1021/jm980137o BindingDB Entry DOI: 10.7270/Q2NV9HCP
					More data for this Ligand-Target Pair
Delta-type opioid receptor/Kappa-type opioid receptor/Mu-type opioid receptor/Sigma non-opioid intracellular receptor 1 (Rattus norvegicus (rat)-RAT)	BDBM50001114 (8-(4-Oxo-1-phenyl-1,3,8-triaza-spiro[4.5]dec-8-ylm...) Show SMILES COC(=O)c1cc2c3OC(CN4CCC5(CC4)N(CNC5=O)c4ccccc4)COc3ccc2[nH]1 Show InChI InChI=1S/C26H28N4O5/c1-33-24(31)21-13-19-20(28-21)7-8-22-23(19)35-18(15-34-22)14-29-11-9-26(10-12-29)25(32)27-16-30(26)17-5-3-2-4-6-17/h2-8,13,18,28H,9-12,14-16H2,1H3,(H,27,32)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	6.5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Upjohn Company Curated by ChEMBL					Assay Description Inhibition of human erythrocyte carbonic anhydrase II				J Med Chem 35: 3058-66 (1992) BindingDB Entry DOI: 10.7270/Q21835G5
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 1D (Homo sapiens (Human))	BDBM50051562 (1-(2-Isochroman-1-yl-ethyl)-4-(4-methoxy-phenyl)-p...) Show SMILES COc1ccc(cc1)N1CCN(CCC2OCCc3ccccc23)CC1 Show InChI InChI=1S/C22H28N2O2/c1-25-20-8-6-19(7-9-20)24-15-13-23(14-16-24)12-10-22-21-5-3-2-4-18(21)11-17-26-22/h2-9,22H,10-17H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	6.70	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Pharmacia & Upjohn Curated by ChEMBL					Assay Description The compound was tested for CNS binding affinity towards 5-hydroxytryptamine 1D receptor from cloned gorilla membranes expressed in cultured HEK 293 ...				J Med Chem 41: 2180-3 (1998) Article DOI: 10.1021/jm980137o BindingDB Entry DOI: 10.7270/Q2NV9HCP
					More data for this Ligand-Target Pair
D(2) dopamine receptor (Homo sapiens (Human))	BDBM50001116 (8-[4-(2-Oxo-2,3-dihydro-benzoimidazol-1-yl)-piperi...) Show SMILES COC(=O)c1cc2c3OC(CN4CCC(CC4)n4c5ccccc5[nH]c4=O)COc3ccc2[nH]1 Show InChI InChI=1S/C25H26N4O5/c1-32-24(30)20-12-17-18(26-20)6-7-22-23(17)34-16(14-33-22)13-28-10-8-15(9-11-28)29-21-5-3-2-4-19(21)27-25(29)31/h2-7,12,15-16,26H,8-11,13-14H2,1H3,(H,27,31)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	PubMed	6.70	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Upjohn Company Curated by ChEMBL					Assay Description Binding affinity towards Dopamine receptor D2 from mammalian clones expressed in CHO cell membranes using 2 (86.1 Ci/mmol,1.7nanoM)as radioligand				J Med Chem 35: 3058-66 (1992) BindingDB Entry DOI: 10.7270/Q21835G5
					More data for this Ligand-Target Pair
D(4) dopamine receptor (RAT)	BDBM50051565 (4-[4-((S)-2-Isochroman-1-yl-ethyl)-piperazin-1-yl]...) Show SMILES NS(=O)(=O)c1ccc(cc1)N1CCN(CC[C@@H]2OCCc3ccccc23)CC1 Show InChI InChI=1S/C21H27N3O3S/c22-28(25,26)19-7-5-18(6-8-19)24-14-12-23(13-15-24)11-9-21-20-4-2-1-3-17(20)10-16-27-21/h1-8,21H,9-16H2,(H2,22,25,26)/t21-/m0/s1	Reactome pathway UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	7.20	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Pharmacia & Upjohn Curated by ChEMBL					Assay Description Binding affinity of [3H]-Spiperone towards Dopamine receptor D4 expressed in cultured cells or from rat whole brain.				J Med Chem 39: 2435-7 (1996) Article DOI: 10.1021/jm960084f BindingDB Entry DOI: 10.7270/Q2H1314Z
					More data for this Ligand-Target Pair
Urotensin-2 receptor (Homo sapiens (Human))	BDBM50249878 ((R)-2-bromo-4,5-dimethoxy-N-(3-(1-methylpyrrolidin...) Show SMILES COc1cc(Br)c(cc1OC)S(=O)(=O)Nc1ccc(c(O[C@@H]2CCN(C)C2)c1)C(F)(F)F |r| Show InChI InChI=1S/C20H22BrF3N2O5S/c1-26-7-6-13(11-26)31-16-8-12(4-5-14(16)20(22,23)24)25-32(27,28)19-10-18(30-3)17(29-2)9-15(19)21/h4-5,8-10,13,25H,6-7,11H2,1-3H3/t13-/m1/s1	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	8	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Johnson& Johnson Pharmaceutical Research& Development Curated by ChEMBL					Assay Description Displacement of [125I]urotensin 2 from urotensin 2 receptor in human RMS13 cells by scintillation proximity assay				J Med Chem 52: 7432-45 (2009) Article DOI: 10.1021/jm900683d BindingDB Entry DOI: 10.7270/Q2S75GD7
					More data for this Ligand-Target Pair
Urotensin-2 receptor (Homo sapiens (Human))	BDBM50302271 ((R)-2-(1-(3,4-dimethoxyphenyl)-4-(6-methoxypyrazin...) Show SMILES CCN1CCN(CC1)c1cccc2C(=O)N(Cc12)[C@H](CCCNc1cncc(OC)n1)c1ccc(OC)c(OC)c1 |r| Show InChI InChI=1S/C31H40N6O4/c1-5-35-14-16-36(17-15-35)26-9-6-8-23-24(26)21-37(31(23)38)25(22-11-12-27(39-2)28(18-22)40-3)10-7-13-33-29-19-32-20-30(34-29)41-4/h6,8-9,11-12,18-20,25H,5,7,10,13-17,21H2,1-4H3,(H,33,34)/t25-/m1/s1	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	8	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Johnson& Johnson Pharmaceutical Research& Development Curated by ChEMBL					Assay Description Displacement of [125I]urotensin 2 from urotensin 2 receptor in human RMS13 cells by scintillation proximity assay				J Med Chem 52: 7432-45 (2009) Article DOI: 10.1021/jm900683d BindingDB Entry DOI: 10.7270/Q2S75GD7
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 1D (Homo sapiens (Human))	BDBM50064785 (1-{2-[4-(4-Methoxy-phenyl)-piperazin-1-yl]-ethyl}-...) Show SMILES COc1ccc(cc1)N1CCN(CCC2OCCc3cc(ccc23)C(N)=O)CC1 Show InChI InChI=1S/C23H29N3O3/c1-28-20-5-3-19(4-6-20)26-13-11-25(12-14-26)10-8-22-21-7-2-18(23(24)27)16-17(21)9-15-29-22/h2-7,16,22H,8-15H2,1H3,(H2,24,27)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	8.60	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Pharmacia & Upjohn Curated by ChEMBL					Assay Description The compound was tested for CNS binding affinity towards 5-hydroxytryptamine 1D receptor from cloned gorilla membranes expressed in cultured HEK 293 ...				J Med Chem 41: 2180-3 (1998) Article DOI: 10.1021/jm980137o BindingDB Entry DOI: 10.7270/Q2NV9HCP
					More data for this Ligand-Target Pair
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor (Rattus norvegicus (rat)-Rattus norvegicus (Rat))	BDBM50001112 (8-(2-Hydroxymethyl-7,8-dihydro-3H-6,9-dioxa-3-aza-...) Show SMILES OCc1cc2c3OC(CN4CCC5(CC4)N(CNC5=O)c4ccccc4)COc3ccc2[nH]1 Show InChI InChI=1S/C25H28N4O4/c30-14-17-12-20-21(27-17)6-7-22-23(20)33-19(15-32-22)13-28-10-8-25(9-11-28)24(31)26-16-29(25)18-4-2-1-3-5-18/h1-7,12,19,27,30H,8-11,13-16H2,(H,26,31)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	8.80	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Upjohn Company Curated by ChEMBL					Assay Description Binding affinity towards Alpha-1 adrenergic receptor from rat whole brain using [3H]prazosin (18.1 Ci/mmol,0.9nanoM)as radioligand				J Med Chem 35: 3058-66 (1992) BindingDB Entry DOI: 10.7270/Q21835G5
					More data for this Ligand-Target Pair
D(4) dopamine receptor (RAT)	BDBM50001884 (2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...) Show SMILES CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2ccccc12 |t:8| Show InChI InChI=1S/C18H19ClN4/c1-22-8-10-23(11-9-22)18-14-4-2-3-5-15(14)20-16-7-6-13(19)12-17(16)21-18/h2-7,12,20H,8-11H2,1H3	Reactome pathway UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem Patents Similars	Article PubMed	9	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Pharmacia & Upjohn Curated by ChEMBL					Assay Description Binding affinity of [3H]-spiperone towards cloned mammalian Dopamine receptor D4 expressed in cultured cells or from rat whole brain				J Med Chem 39: 2435-7 (1996) Article DOI: 10.1021/jm960084f BindingDB Entry DOI: 10.7270/Q2H1314Z
					More data for this Ligand-Target Pair
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor (Rattus norvegicus (rat)-Rattus norvegicus (Rat))	BDBM50001114 (8-(4-Oxo-1-phenyl-1,3,8-triaza-spiro[4.5]dec-8-ylm...) Show SMILES COC(=O)c1cc2c3OC(CN4CCC5(CC4)N(CNC5=O)c4ccccc4)COc3ccc2[nH]1 Show InChI InChI=1S/C26H28N4O5/c1-33-24(31)21-13-19-20(28-21)7-8-22-23(19)35-18(15-34-22)14-29-11-9-26(10-12-29)25(32)27-16-30(26)17-5-3-2-4-6-17/h2-8,13,18,28H,9-12,14-16H2,1H3,(H,27,32)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	11	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Upjohn Company Curated by ChEMBL					Assay Description Compound was evaluated for the binding affinity towards Alpha-1 adrenergic receptor from rat whole brain using [3H]prazosin as radioligand				J Med Chem 35: 3058-66 (1992) BindingDB Entry DOI: 10.7270/Q21835G5
					More data for this Ligand-Target Pair
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor (Rattus norvegicus (rat)-Rattus norvegicus (Rat))	BDBM50001115 (8-[(3-Phenyl-propylamino)-methyl]-7,8-dihydro-3H-6...) Show SMILES O=C(NCCCc1ccccc1)c1cc2c3OC(CNCCCc4ccccc4)COc3ccc2[nH]1 Show InChI InChI=1S/C30H33N3O3/c34-30(32-18-8-14-23-11-5-2-6-12-23)27-19-25-26(33-27)15-16-28-29(25)36-24(21-35-28)20-31-17-7-13-22-9-3-1-4-10-22/h1-6,9-12,15-16,19,24,31,33H,7-8,13-14,17-18,20-21H2,(H,32,34)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents	PubMed	11	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Upjohn Company Curated by ChEMBL					Assay Description Binding affinity towards Alpha-1 adrenergic receptor from rat whole brain using [3H]prazosin (18.1 Ci/mmol,0.9nanoM)as radioligand				J Med Chem 35: 3058-66 (1992) BindingDB Entry DOI: 10.7270/Q21835G5
					More data for this Ligand-Target Pair
Urotensin-2 receptor (Homo sapiens (Human))	BDBM50302267 ((R)-N-(4-(3,4-dimethoxyphenyl)-4-(4-(4-ethylpipera...) Show SMILES CCN1CCN(CC1)c1cccc2C(=O)N(Cc12)[C@H](CCCNC(=O)c1c(C)n[nH]c1C)c1ccc(OC)c(OC)c1 |r| Show InChI InChI=1S/C32H42N6O4/c1-6-36-15-17-37(18-16-36)27-10-7-9-24-25(27)20-38(32(24)40)26(23-12-13-28(41-4)29(19-23)42-5)11-8-14-33-31(39)30-21(2)34-35-22(30)3/h7,9-10,12-13,19,26H,6,8,11,14-18,20H2,1-5H3,(H,33,39)(H,34,35)/t26-/m1/s1	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	11	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Johnson& Johnson Pharmaceutical Research& Development Curated by ChEMBL					Assay Description Displacement of [125I]urotensin 2 from urotensin 2 receptor in human RMS13 cells by scintillation proximity assay				J Med Chem 52: 7432-45 (2009) Article DOI: 10.1021/jm900683d BindingDB Entry DOI: 10.7270/Q2S75GD7
					More data for this Ligand-Target Pair
Urotensin-2 receptor (Homo sapiens (Human))	BDBM50302264 ((R)-N-(4-(3,4-dimethoxyphenyl)-4-(4-(4-isopropylpi...) Show SMILES COc1ccc(cc1OC)[C@@H](CCCN(C)S(=O)(=O)c1cccs1)N1Cc2c(cccc2N2CCN(CC2)C(C)C)C1=O |r| Show InChI InChI=1S/C32H42N4O5S2/c1-23(2)34-16-18-35(19-17-34)28-10-6-9-25-26(28)22-36(32(25)37)27(24-13-14-29(40-4)30(21-24)41-5)11-7-15-33(3)43(38,39)31-12-8-20-42-31/h6,8-10,12-14,20-21,23,27H,7,11,15-19,22H2,1-5H3/t27-/m1/s1	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	11	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Johnson& Johnson Pharmaceutical Research& Development Curated by ChEMBL					Assay Description Displacement of [125I]urotensin 2 from urotensin 2 receptor in human RMS13 cells by scintillation proximity assay				J Med Chem 52: 7432-45 (2009) Article DOI: 10.1021/jm900683d BindingDB Entry DOI: 10.7270/Q2S75GD7
					More data for this Ligand-Target Pair

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