Found 34 hits with Last Name = 'lim' and Initial = 'cs' Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Sigma intracellular receptor 2
(Homo sapiens (Human)) | BDBM349368
(US10207991, Ex. Cpd. No. 11 | US10611728, Example ...)Show SMILES COc1cc2CN(Cc2cc1OC)[C@H](C)CCc1ccc(Cl)c(Cl)c1 |r| Show InChI InChI=1S/C20H23Cl2NO2/c1-13(4-5-14-6-7-17(21)18(22)8-14)23-11-15-9-19(24-2)20(25-3)10-16(15)12-23/h6-10,13H,4-5,11-12H2,1-3H3/t13-/m1/s1 | UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| 0.440 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Binding affinity to Sigma 2-receptor (unknown origin) |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.1c00048 BindingDB Entry DOI: 10.7270/Q21C21Q9 |
More data for this Ligand-Target Pair | |
Sigma intracellular receptor 2
(Homo sapiens (Human)) | BDBM349547
(US10207991, Ex. Cpd. No. 62 | US10611728, Example ...)Show SMILES CC(C)(C)Oc1cc(CCC(C)(C)N2Cc3ccc(cc3C2)S(C)(=O)=O)ccc1O Show InChI InChI=1S/C24H33NO4S/c1-23(2,3)29-22-13-17(7-10-21(22)26)11-12-24(4,5)25-15-18-8-9-20(30(6,27)28)14-19(18)16-25/h7-10,13-14,26H,11-12,15-16H2,1-6H3 | UniProtKB/SwissProt
GoogleScholar AffyNet
| Purchase
MCE PC cid PC sid UniChem
| Article PubMed
| 8.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Binding affinity to Sigma 2-receptor (unknown origin) |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.1c00048 BindingDB Entry DOI: 10.7270/Q21C21Q9 |
More data for this Ligand-Target Pair | |
Sigma intracellular receptor 2
(Homo sapiens (Human)) | BDBM50577481
(CHEMBL4865307) | UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| 9 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Binding affinity to Sigma 2-receptor (unknown origin) |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.1c00048 BindingDB Entry DOI: 10.7270/Q21C21Q9 |
More data for this Ligand-Target Pair | |
Sigma intracellular receptor 2
(Homo sapiens (Human)) | BDBM349513
(US10207991, Ex. Cpd. No. 28 | US10611728, Example ...)Show InChI InChI=1S/C22H28FNO2/c1-15(2)26-21-12-16(8-9-20(21)25)10-11-22(3,4)24-13-17-6-5-7-19(23)18(17)14-24/h5-9,12,15,25H,10-11,13-14H2,1-4H3 | UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| 11 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Binding affinity to Sigma 2-receptor (unknown origin) |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.1c00048 BindingDB Entry DOI: 10.7270/Q21C21Q9 |
More data for this Ligand-Target Pair | |
Sigma intracellular receptor 2
(Homo sapiens (Human)) | BDBM50577482
(CHEMBL4848550)Show SMILES C[C@H](CCc1ccc(Cl)c(Cl)c1)NCc1ccc(cc1)C(F)(F)F |r| | UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| 48 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Binding affinity to Sigma 2-receptor (unknown origin) |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.1c00048 BindingDB Entry DOI: 10.7270/Q21C21Q9 |
More data for this Ligand-Target Pair | |
Sigma intracellular receptor 2
(Homo sapiens (Human)) | BDBM50577484
(CHEMBL4863873)Show SMILES C[C@H](CCc1ccc(Cl)cc1)NCc1ccc(cc1)C(F)(F)F |r| | UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| 50 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Binding affinity to Sigma 2-receptor (unknown origin) |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.1c00048 BindingDB Entry DOI: 10.7270/Q21C21Q9 |
More data for this Ligand-Target Pair | |
Sigma intracellular receptor 2
(Homo sapiens (Human)) | BDBM349324
(US10207991, Ex. Cpd. No. 8 | US10611728, Example C...)Show SMILES COc1cc(CC[C@@H](C)N2Cc3cccc(F)c3C2)ccc1O |r| Show InChI InChI=1S/C19H22FNO2/c1-13(6-7-14-8-9-18(22)19(10-14)23-2)21-11-15-4-3-5-17(20)16(15)12-21/h3-5,8-10,13,22H,6-7,11-12H2,1-2H3/t13-/m1/s1 | UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| 79 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Binding affinity to Sigma 2-receptor (unknown origin) |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.1c00048 BindingDB Entry DOI: 10.7270/Q21C21Q9 |
More data for this Ligand-Target Pair | |
Sigma intracellular receptor 2
(Homo sapiens (Human)) | BDBM50577483
(CHEMBL4869437)Show SMILES C[C@@H](CCc1ccc(Cl)c(Cl)c1)NCc1ccc(cc1)C(F)(F)F |r| | UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| 120 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Binding affinity to Sigma 2-receptor (unknown origin) |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.1c00048 BindingDB Entry DOI: 10.7270/Q21C21Q9 |
More data for this Ligand-Target Pair | |
DNA gyrase subunit A
(Escherichia coli) | BDBM21690
(1-cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,...)Show InChI InChI=1S/C17H18FN3O3/c18-13-7-11-14(8-15(13)20-5-3-19-4-6-20)21(10-1-2-10)9-12(16(11)22)17(23)24/h7-10,19H,1-6H2,(H,23,24) | PDB
UniProtKB/TrEMBL
GoogleScholar AffyNet
| Purchase
CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 280 | n/a | n/a | n/a | n/a | n/a | n/a |
Imperial College London
Curated by ChEMBL
| Assay Description Inhibition of Escherichia coli DNA gyrase (A2B2 tetramer) using relaxed pBR322 as substrate preincubated for 30 mins followed by enzyme addition by S... |
Bioorg Med Chem 27: (2019)
Article DOI: 10.1016/j.bmc.2019.06.025 BindingDB Entry DOI: 10.7270/Q2JM2F2T |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
(Homo sapiens (Human)) | BDBM117067
(US8664230, 3)Show SMILES Fc1ccc(c(F)c1)S(=O)(=O)Nc1cc(cnc1Cl)-c1ccc2ncnc(OC3CCOCC3)c2n1 Show InChI InChI=1S/C23H18ClF2N5O4S/c24-22-19(31-36(32,33)20-4-1-14(25)10-16(20)26)9-13(11-27-22)17-2-3-18-21(30-17)23(29-12-28-18)35-15-5-7-34-8-6-15/h1-4,9-12,15,31H,5-8H2 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| US Patent
| n/a | n/a | <1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
The Asan Foundation
US Patent
| Assay Description The PI3 Kinase Activity/Inhibitor Assay is a competitive assay used for the fast and sensitive quantitation of activity of the four class I PI3 kinas... |
US Patent US8664230 (2014)
BindingDB Entry DOI: 10.7270/Q2N58K1R |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
(Homo sapiens (Human)) | BDBM117066
(US8664230, 2)Show SMILES O=S(=O)(Nc1cncc(c1)-c1ccc2ncnc(OC3CCOCC3)c2n1)c1ccccc1 Show InChI InChI=1S/C23H21N5O4S/c29-33(30,19-4-2-1-3-5-19)28-17-12-16(13-24-14-17)20-6-7-21-22(27-20)23(26-15-25-21)32-18-8-10-31-11-9-18/h1-7,12-15,18,28H,8-11H2 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| US Patent
| n/a | n/a | <1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
The Asan Foundation
US Patent
| Assay Description The PI3 Kinase Activity/Inhibitor Assay is a competitive assay used for the fast and sensitive quantitation of activity of the four class I PI3 kinas... |
US Patent US8664230 (2014)
BindingDB Entry DOI: 10.7270/Q2N58K1R |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 3-kinase regulatory subunit alpha
(Homo sapiens (Human)) | BDBM117067
(US8664230, 3)Show SMILES Fc1ccc(c(F)c1)S(=O)(=O)Nc1cc(cnc1Cl)-c1ccc2ncnc(OC3CCOCC3)c2n1 Show InChI InChI=1S/C23H18ClF2N5O4S/c24-22-19(31-36(32,33)20-4-1-14(25)10-16(20)26)9-13(11-27-22)17-2-3-18-21(30-17)23(29-12-28-18)35-15-5-7-34-8-6-15/h1-4,9-12,15,31H,5-8H2 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| US Patent
| n/a | n/a | <1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
The Asan Foundation
US Patent
| Assay Description The PI3 Kinase Activity/Inhibitor Assay is a competitive assay used for the fast and sensitive quantitation of activity of the four class I PI3 kinas... |
US Patent US8664230 (2014)
BindingDB Entry DOI: 10.7270/Q2N58K1R |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
(Homo sapiens (Human)) | BDBM117065
(US8664230, 1)Show SMILES O=S(=O)(Nc1cncc(c1)-c1ccc2ncnc(Oc3cccnc3)c2n1)c1ccccc1 Show InChI InChI=1S/C23H16N6O3S/c30-33(31,19-6-2-1-3-7-19)29-17-11-16(12-25-13-17)20-8-9-21-22(28-20)23(27-15-26-21)32-18-5-4-10-24-14-18/h1-15,29H | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | <1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
The Asan Foundation
US Patent
| Assay Description The PI3 Kinase Activity/Inhibitor Assay is a competitive assay used for the fast and sensitive quantitation of activity of the four class I PI3 kinas... |
US Patent US8664230 (2014)
BindingDB Entry DOI: 10.7270/Q2N58K1R |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
(Homo sapiens (Human)) | BDBM117067
(US8664230, 3)Show SMILES Fc1ccc(c(F)c1)S(=O)(=O)Nc1cc(cnc1Cl)-c1ccc2ncnc(OC3CCOCC3)c2n1 Show InChI InChI=1S/C23H18ClF2N5O4S/c24-22-19(31-36(32,33)20-4-1-14(25)10-16(20)26)9-13(11-27-22)17-2-3-18-21(30-17)23(29-12-28-18)35-15-5-7-34-8-6-15/h1-4,9-12,15,31H,5-8H2 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| US Patent
| n/a | n/a | <1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
The Asan Foundation
US Patent
| Assay Description The PI3 Kinase Activity/Inhibitor Assay is a competitive assay used for the fast and sensitive quantitation of activity of the four class I PI3 kinas... |
US Patent US8664230 (2014)
BindingDB Entry DOI: 10.7270/Q2N58K1R |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
(Homo sapiens (Human)) | BDBM117068
(US8664230, 4)Show SMILES CN1CCC(CC1)Oc1ncnc2ccc(nc12)-c1cnc(Cl)c(NS(=O)(=O)c2ccc(F)cc2F)c1 Show InChI InChI=1S/C24H21ClF2N6O3S/c1-33-8-6-16(7-9-33)36-24-22-19(29-13-30-24)4-3-18(31-22)14-10-20(23(25)28-12-14)32-37(34,35)21-5-2-15(26)11-17(21)27/h2-5,10-13,16,32H,6-9H2,1H3 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| US Patent
| n/a | n/a | <1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
The Asan Foundation
US Patent
| Assay Description The PI3 Kinase Activity/Inhibitor Assay is a competitive assay used for the fast and sensitive quantitation of activity of the four class I PI3 kinas... |
US Patent US8664230 (2014)
BindingDB Entry DOI: 10.7270/Q2N58K1R |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 3-kinase regulatory subunit alpha
(Homo sapiens (Human)) | BDBM117068
(US8664230, 4)Show SMILES CN1CCC(CC1)Oc1ncnc2ccc(nc12)-c1cnc(Cl)c(NS(=O)(=O)c2ccc(F)cc2F)c1 Show InChI InChI=1S/C24H21ClF2N6O3S/c1-33-8-6-16(7-9-33)36-24-22-19(29-13-30-24)4-3-18(31-22)14-10-20(23(25)28-12-14)32-37(34,35)21-5-2-15(26)11-17(21)27/h2-5,10-13,16,32H,6-9H2,1H3 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| US Patent
| n/a | n/a | <1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
The Asan Foundation
US Patent
| Assay Description The PI3 Kinase Activity/Inhibitor Assay is a competitive assay used for the fast and sensitive quantitation of activity of the four class I PI3 kinas... |
US Patent US8664230 (2014)
BindingDB Entry DOI: 10.7270/Q2N58K1R |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
(Homo sapiens (Human)) | BDBM117068
(US8664230, 4)Show SMILES CN1CCC(CC1)Oc1ncnc2ccc(nc12)-c1cnc(Cl)c(NS(=O)(=O)c2ccc(F)cc2F)c1 Show InChI InChI=1S/C24H21ClF2N6O3S/c1-33-8-6-16(7-9-33)36-24-22-19(29-13-30-24)4-3-18(31-22)14-10-20(23(25)28-12-14)32-37(34,35)21-5-2-15(26)11-17(21)27/h2-5,10-13,16,32H,6-9H2,1H3 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| US Patent
| n/a | n/a | <1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
The Asan Foundation
US Patent
| Assay Description The PI3 Kinase Activity/Inhibitor Assay is a competitive assay used for the fast and sensitive quantitation of activity of the four class I PI3 kinas... |
US Patent US8664230 (2014)
BindingDB Entry DOI: 10.7270/Q2N58K1R |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
(Homo sapiens (Human)) | BDBM117070
(US8664230, 6)Show SMILES Fc1ccc(c(F)c1)S(=O)(=O)Nc1cc(cnc1Cl)-c1ccc2ncnc(NC3CCOCC3)c2n1 Show InChI InChI=1S/C23H19ClF2N6O3S/c24-22-19(32-36(33,34)20-4-1-14(25)10-16(20)26)9-13(11-27-22)17-2-3-18-21(31-17)23(29-12-28-18)30-15-5-7-35-8-6-15/h1-4,9-12,15,32H,5-8H2,(H,28,29,30) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | <1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
The Asan Foundation
US Patent
| Assay Description The PI3 Kinase Activity/Inhibitor Assay is a competitive assay used for the fast and sensitive quantitation of activity of the four class I PI3 kinas... |
US Patent US8664230 (2014)
BindingDB Entry DOI: 10.7270/Q2N58K1R |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
(Homo sapiens (Human)) | BDBM117069
(US8664230, 5)Show SMILES CN1CCC(CC1)Oc1ncnc2ccc(nc12)-c1cncc(NS(=O)(=O)c2ccccc2)c1 Show InChI InChI=1S/C24H24N6O3S/c1-30-11-9-19(10-12-30)33-24-23-22(26-16-27-24)8-7-21(28-23)17-13-18(15-25-14-17)29-34(31,32)20-5-3-2-4-6-20/h2-8,13-16,19,29H,9-12H2,1H3 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| US Patent
| n/a | n/a | <1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
The Asan Foundation
US Patent
| Assay Description The PI3 Kinase Activity/Inhibitor Assay is a competitive assay used for the fast and sensitive quantitation of activity of the four class I PI3 kinas... |
US Patent US8664230 (2014)
BindingDB Entry DOI: 10.7270/Q2N58K1R |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
(Homo sapiens (Human)) | BDBM117066
(US8664230, 2)Show SMILES O=S(=O)(Nc1cncc(c1)-c1ccc2ncnc(OC3CCOCC3)c2n1)c1ccccc1 Show InChI InChI=1S/C23H21N5O4S/c29-33(30,19-4-2-1-3-5-19)28-17-12-16(13-24-14-17)20-6-7-21-22(27-20)23(26-15-25-21)32-18-8-10-31-11-9-18/h1-7,12-15,18,28H,8-11H2 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| US Patent
| n/a | n/a | <1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
The Asan Foundation
US Patent
| Assay Description The PI3 Kinase Activity/Inhibitor Assay is a competitive assay used for the fast and sensitive quantitation of activity of the four class I PI3 kinas... |
US Patent US8664230 (2014)
BindingDB Entry DOI: 10.7270/Q2N58K1R |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
(Homo sapiens (Human)) | BDBM117065
(US8664230, 1)Show SMILES O=S(=O)(Nc1cncc(c1)-c1ccc2ncnc(Oc3cccnc3)c2n1)c1ccccc1 Show InChI InChI=1S/C23H16N6O3S/c30-33(31,19-6-2-1-3-7-19)29-17-11-16(12-25-13-17)20-8-9-21-22(28-20)23(27-15-26-21)32-18-5-4-10-24-14-18/h1-15,29H | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | <1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
The Asan Foundation
US Patent
| Assay Description The PI3 Kinase Activity/Inhibitor Assay is a competitive assay used for the fast and sensitive quantitation of activity of the four class I PI3 kinas... |
US Patent US8664230 (2014)
BindingDB Entry DOI: 10.7270/Q2N58K1R |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
(Homo sapiens (Human)) | BDBM117070
(US8664230, 6)Show SMILES Fc1ccc(c(F)c1)S(=O)(=O)Nc1cc(cnc1Cl)-c1ccc2ncnc(NC3CCOCC3)c2n1 Show InChI InChI=1S/C23H19ClF2N6O3S/c24-22-19(32-36(33,34)20-4-1-14(25)10-16(20)26)9-13(11-27-22)17-2-3-18-21(31-17)23(29-12-28-18)30-15-5-7-35-8-6-15/h1-4,9-12,15,32H,5-8H2,(H,28,29,30) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | <1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
The Asan Foundation
US Patent
| Assay Description The PI3 Kinase Activity/Inhibitor Assay is a competitive assay used for the fast and sensitive quantitation of activity of the four class I PI3 kinas... |
US Patent US8664230 (2014)
BindingDB Entry DOI: 10.7270/Q2N58K1R |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
(Homo sapiens (Human)) | BDBM117069
(US8664230, 5)Show SMILES CN1CCC(CC1)Oc1ncnc2ccc(nc12)-c1cncc(NS(=O)(=O)c2ccccc2)c1 Show InChI InChI=1S/C24H24N6O3S/c1-30-11-9-19(10-12-30)33-24-23-22(26-16-27-24)8-7-21(28-23)17-13-18(15-25-14-17)29-34(31,32)20-5-3-2-4-6-20/h2-8,13-16,19,29H,9-12H2,1H3 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| US Patent
| n/a | n/a | <1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
The Asan Foundation
US Patent
| Assay Description The PI3 Kinase Activity/Inhibitor Assay is a competitive assay used for the fast and sensitive quantitation of activity of the four class I PI3 kinas... |
US Patent US8664230 (2014)
BindingDB Entry DOI: 10.7270/Q2N58K1R |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 3-kinase regulatory subunit alpha
(Homo sapiens (Human)) | BDBM117070
(US8664230, 6)Show SMILES Fc1ccc(c(F)c1)S(=O)(=O)Nc1cc(cnc1Cl)-c1ccc2ncnc(NC3CCOCC3)c2n1 Show InChI InChI=1S/C23H19ClF2N6O3S/c24-22-19(32-36(33,34)20-4-1-14(25)10-16(20)26)9-13(11-27-22)17-2-3-18-21(31-17)23(29-12-28-18)30-15-5-7-35-8-6-15/h1-4,9-12,15,32H,5-8H2,(H,28,29,30) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | <1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
The Asan Foundation
US Patent
| Assay Description The PI3 Kinase Activity/Inhibitor Assay is a competitive assay used for the fast and sensitive quantitation of activity of the four class I PI3 kinas... |
US Patent US8664230 (2014)
BindingDB Entry DOI: 10.7270/Q2N58K1R |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 3-kinase regulatory subunit alpha
(Homo sapiens (Human)) | BDBM117069
(US8664230, 5)Show SMILES CN1CCC(CC1)Oc1ncnc2ccc(nc12)-c1cncc(NS(=O)(=O)c2ccccc2)c1 Show InChI InChI=1S/C24H24N6O3S/c1-30-11-9-19(10-12-30)33-24-23-22(26-16-27-24)8-7-21(28-23)17-13-18(15-25-14-17)29-34(31,32)20-5-3-2-4-6-20/h2-8,13-16,19,29H,9-12H2,1H3 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| US Patent
| n/a | n/a | <1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
The Asan Foundation
US Patent
| Assay Description The PI3 Kinase Activity/Inhibitor Assay is a competitive assay used for the fast and sensitive quantitation of activity of the four class I PI3 kinas... |
US Patent US8664230 (2014)
BindingDB Entry DOI: 10.7270/Q2N58K1R |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 3-kinase regulatory subunit alpha
(Homo sapiens (Human)) | BDBM117065
(US8664230, 1)Show SMILES O=S(=O)(Nc1cncc(c1)-c1ccc2ncnc(Oc3cccnc3)c2n1)c1ccccc1 Show InChI InChI=1S/C23H16N6O3S/c30-33(31,19-6-2-1-3-7-19)29-17-11-16(12-25-13-17)20-8-9-21-22(28-20)23(27-15-26-21)32-18-5-4-10-24-14-18/h1-15,29H | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | <1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
The Asan Foundation
US Patent
| Assay Description The PI3 Kinase Activity/Inhibitor Assay is a competitive assay used for the fast and sensitive quantitation of activity of the four class I PI3 kinas... |
US Patent US8664230 (2014)
BindingDB Entry DOI: 10.7270/Q2N58K1R |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 3-kinase regulatory subunit alpha
(Homo sapiens (Human)) | BDBM117066
(US8664230, 2)Show SMILES O=S(=O)(Nc1cncc(c1)-c1ccc2ncnc(OC3CCOCC3)c2n1)c1ccccc1 Show InChI InChI=1S/C23H21N5O4S/c29-33(30,19-4-2-1-3-5-19)28-17-12-16(13-24-14-17)20-6-7-21-22(27-20)23(26-15-25-21)32-18-8-10-31-11-9-18/h1-7,12-15,18,28H,8-11H2 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| US Patent
| n/a | n/a | <1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
The Asan Foundation
US Patent
| Assay Description The PI3 Kinase Activity/Inhibitor Assay is a competitive assay used for the fast and sensitive quantitation of activity of the four class I PI3 kinas... |
US Patent US8664230 (2014)
BindingDB Entry DOI: 10.7270/Q2N58K1R |
More data for this Ligand-Target Pair | |
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human)) | BDBM50577482
(CHEMBL4848550)Show SMILES C[C@H](CCc1ccc(Cl)c(Cl)c1)NCc1ccc(cc1)C(F)(F)F |r| | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | n/a | n/a | 4.40E+3 | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of human ERG expressed in CHO cells measured by Patch-clamp assay |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.1c00048 BindingDB Entry DOI: 10.7270/Q21C21Q9 |
More data for this Ligand-Target Pair | |
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human)) | BDBM50577483
(CHEMBL4869437)Show SMILES C[C@@H](CCc1ccc(Cl)c(Cl)c1)NCc1ccc(cc1)C(F)(F)F |r| | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | n/a | n/a | 1.10E+3 | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of human ERG expressed in CHO cells measured by Patch-clamp assay |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.1c00048 BindingDB Entry DOI: 10.7270/Q21C21Q9 |
More data for this Ligand-Target Pair | |
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human)) | BDBM50577484
(CHEMBL4863873)Show SMILES C[C@H](CCc1ccc(Cl)cc1)NCc1ccc(cc1)C(F)(F)F |r| | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | n/a | n/a | 780 | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of human ERG expressed in CHO cells measured by Patch-clamp assay |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.1c00048 BindingDB Entry DOI: 10.7270/Q21C21Q9 |
More data for this Ligand-Target Pair | |
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human)) | BDBM349368
(US10207991, Ex. Cpd. No. 11 | US10611728, Example ...)Show SMILES COc1cc2CN(Cc2cc1OC)[C@H](C)CCc1ccc(Cl)c(Cl)c1 |r| Show InChI InChI=1S/C20H23Cl2NO2/c1-13(4-5-14-6-7-17(21)18(22)8-14)23-11-15-9-19(24-2)20(25-3)10-16(15)12-23/h6-10,13H,4-5,11-12H2,1-3H3/t13-/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | n/a | n/a | 290 | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of human ERG expressed in CHO cells measured by Patch-clamp assay |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.1c00048 BindingDB Entry DOI: 10.7270/Q21C21Q9 |
More data for this Ligand-Target Pair | |
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human)) | BDBM349324
(US10207991, Ex. Cpd. No. 8 | US10611728, Example C...)Show SMILES COc1cc(CC[C@@H](C)N2Cc3cccc(F)c3C2)ccc1O |r| Show InChI InChI=1S/C19H22FNO2/c1-13(6-7-14-8-9-18(22)19(10-14)23-2)21-11-15-4-3-5-17(20)16(15)12-21/h3-5,8-10,13,22H,6-7,11-12H2,1-2H3/t13-/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | n/a | n/a | 7.00E+3 | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of human ERG expressed in CHO cells measured by Patch-clamp assay |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.1c00048 BindingDB Entry DOI: 10.7270/Q21C21Q9 |
More data for this Ligand-Target Pair | |
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human)) | BDBM349513
(US10207991, Ex. Cpd. No. 28 | US10611728, Example ...)Show InChI InChI=1S/C22H28FNO2/c1-15(2)26-21-12-16(8-9-20(21)25)10-11-22(3,4)24-13-17-6-5-7-19(23)18(17)14-24/h5-9,12,15,25H,10-11,13-14H2,1-4H3 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | n/a | n/a | 9.60E+3 | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of human ERG expressed in CHO cells measured by Patch-clamp assay |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.1c00048 BindingDB Entry DOI: 10.7270/Q21C21Q9 |
More data for this Ligand-Target Pair | |
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human)) | BDBM349547
(US10207991, Ex. Cpd. No. 62 | US10611728, Example ...)Show SMILES CC(C)(C)Oc1cc(CCC(C)(C)N2Cc3ccc(cc3C2)S(C)(=O)=O)ccc1O Show InChI InChI=1S/C24H33NO4S/c1-23(2,3)29-22-13-17(7-10-21(22)26)11-12-24(4,5)25-15-18-8-9-20(30(6,27)28)14-19(18)16-25/h7-10,13-14,26H,11-12,15-16H2,1-6H3 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
MCE PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | n/a | n/a | 2.60E+4 | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of human ERG expressed in CHO cells measured by Patch-clamp assay |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.1c00048 BindingDB Entry DOI: 10.7270/Q21C21Q9 |
More data for this Ligand-Target Pair | |