Compile Data Set for Download or QSAR

Found 19 hits with Last Name = 'mielech' and Initial = 'am'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Replicase polyprotein 1a (Human coronavirus NL63)	BDBM50007789 (CHEMBL1173044 | GRL-0667 | N-(2H-1,3-benzodioxol-5...) Show SMILES C[C@@H](N1CCC(CC1)C(=O)NCc1ccc2OCOc2c1)c1cccc2ccccc12 |r| Show InChI InChI=1S/C26H28N2O3/c1-18(22-8-4-6-20-5-2-3-7-23(20)22)28-13-11-21(12-14-28)26(29)27-16-19-9-10-24-25(15-19)31-17-30-24/h2-10,15,18,21H,11-14,16-17H2,1H3,(H,27,29)/t18-/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	1.80E+4	n/a	n/a	n/a	n/a	n/a	n/a
Purdue University Curated by ChEMBL					Assay Description Inhibition of human coronavirus NL63 PLP2 (amino acids 1565 to 1894) expressed in Escherichia coli BL21 (DE3) cells assessed as reduction of AMC rele...				J Med Chem 57: 2393-412 (2014) Article DOI: 10.1021/jm401712t BindingDB Entry DOI: 10.7270/Q2KK9DBM
					More data for this Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 21 (Homo sapiens (Human))	BDBM50007791 (CHEMBL3233815 | med.21724, Compound 168) Show SMILES C[C@@H](N1CCC(CC1)C(=O)NCc1cccc(F)c1)c1cccc2ccccc12 |r| Show InChI InChI=1S/C25H27FN2O/c1-18(23-11-5-8-20-7-2-3-10-24(20)23)28-14-12-21(13-15-28)25(29)27-17-19-6-4-9-22(26)16-19/h2-11,16,18,21H,12-15,17H2,1H3,(H,27,29)/t18-/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	>3.10E+4	n/a	n/a	n/a	n/a	n/a	n/a
Purdue University Curated by ChEMBL					Assay Description Inhibition of human USP21 using Ub-rhodamine 110 as substrate				J Med Chem 57: 2393-412 (2014) Article DOI: 10.1021/jm401712t BindingDB Entry DOI: 10.7270/Q2KK9DBM
					More data for this Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 21 (Homo sapiens (Human))	BDBM50007790 (CHEMBL3233814 | med.21724, Compound 169) Show SMILES C[C@@H](N1CCC(CC1)C(=O)NCc1ccc(F)cc1)c1cccc2ccccc12 |r| Show InChI InChI=1S/C25H27FN2O/c1-18(23-8-4-6-20-5-2-3-7-24(20)23)28-15-13-21(14-16-28)25(29)27-17-19-9-11-22(26)12-10-19/h2-12,18,21H,13-17H2,1H3,(H,27,29)/t18-/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	>3.10E+4	n/a	n/a	n/a	n/a	n/a	n/a
Purdue University Curated by ChEMBL					Assay Description Inhibition of human USP21 using Ub-rhodamine 110 as substrate				J Med Chem 57: 2393-412 (2014) Article DOI: 10.1021/jm401712t BindingDB Entry DOI: 10.7270/Q2KK9DBM
					More data for this Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 21 (Homo sapiens (Human))	BDBM50007788 (CHEMBL3233809 | med.21724, Compound 167) Show SMILES C[C@@H](N1CCC(CC1)C(=O)NCc1cccc(NC(C)=O)c1)c1cccc2ccccc12 |r| Show InChI InChI=1S/C27H31N3O2/c1-19(25-12-6-9-22-8-3-4-11-26(22)25)30-15-13-23(14-16-30)27(32)28-18-21-7-5-10-24(17-21)29-20(2)31/h3-12,17,19,23H,13-16,18H2,1-2H3,(H,28,32)(H,29,31)/t19-/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	>3.10E+4	n/a	n/a	n/a	n/a	n/a	n/a
Purdue University Curated by ChEMBL					Assay Description Inhibition of human USP21 using Ub-rhodamine 110 as substrate				J Med Chem 57: 2393-412 (2014) Article DOI: 10.1021/jm401712t BindingDB Entry DOI: 10.7270/Q2KK9DBM
					More data for this Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 21 (Homo sapiens (Human))	BDBM50007789 (CHEMBL1173044 | GRL-0667 | N-(2H-1,3-benzodioxol-5...) Show SMILES C[C@@H](N1CCC(CC1)C(=O)NCc1ccc2OCOc2c1)c1cccc2ccccc12 |r| Show InChI InChI=1S/C26H28N2O3/c1-18(22-8-4-6-20-5-2-3-7-23(20)22)28-13-11-21(12-14-28)26(29)27-16-19-9-10-24-25(15-19)31-17-30-24/h2-10,15,18,21H,11-14,16-17H2,1H3,(H,27,29)/t18-/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	>3.10E+4	n/a	n/a	n/a	n/a	n/a	n/a
Purdue University Curated by ChEMBL					Assay Description Inhibition of human USP21 using Ub-rhodamine 110 as substrate				J Med Chem 57: 2393-412 (2014) Article DOI: 10.1021/jm401712t BindingDB Entry DOI: 10.7270/Q2KK9DBM
					More data for this Ligand-Target Pair
Replicase polyprotein 1a (Human coronavirus NL63)	BDBM50007791 (CHEMBL3233815 | med.21724, Compound 168) Show SMILES C[C@@H](N1CCC(CC1)C(=O)NCc1cccc(F)c1)c1cccc2ccccc12 |r| Show InChI InChI=1S/C25H27FN2O/c1-18(23-11-5-8-20-7-2-3-10-24(20)23)28-14-12-21(13-15-28)25(29)27-17-19-6-4-9-22(26)16-19/h2-11,16,18,21H,12-15,17H2,1H3,(H,27,29)/t18-/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	3.30E+4	n/a	n/a	n/a	n/a	n/a	n/a
Purdue University Curated by ChEMBL					Assay Description Inhibition of human coronavirus NL63 PLP2 (amino acids 1565 to 1894) expressed in Escherichia coli BL21 (DE3) cells assessed as reduction of AMC rele...				J Med Chem 57: 2393-412 (2014) Article DOI: 10.1021/jm401712t BindingDB Entry DOI: 10.7270/Q2KK9DBM
					More data for this Ligand-Target Pair
Replicase polyprotein 1a (Human coronavirus NL63)	BDBM50007792 (CHEMBL3233808) Show SMILES C[C@@H](N1CCC(CC1)C(=O)NCc1ccc(NC(C)=O)cc1)c1cccc2ccccc12 |r| Show InChI InChI=1S/C27H31N3O2/c1-19(25-9-5-7-22-6-3-4-8-26(22)25)30-16-14-23(15-17-30)27(32)28-18-21-10-12-24(13-11-21)29-20(2)31/h3-13,19,23H,14-18H2,1-2H3,(H,28,32)(H,29,31)/t19-/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.70E+4	n/a	n/a	n/a	n/a	n/a	n/a
Purdue University Curated by ChEMBL					Assay Description Inhibition of human coronavirus NL63 PLP2 (amino acids 1565 to 1894) expressed in Escherichia coli BL21 (DE3) cells assessed as reduction of AMC rele...				J Med Chem 57: 2393-412 (2014) Article DOI: 10.1021/jm401712t BindingDB Entry DOI: 10.7270/Q2KK9DBM
					More data for this Ligand-Target Pair
Replicase polyprotein 1a (Human coronavirus NL63)	BDBM50007793 (CHEMBL3233813) Show SMILES C[C@@H](N1CCC(CC1)C(=O)NCc1ccc(F)c(F)c1)c1cccc2ccccc12 |r| Show InChI InChI=1S/C25H26F2N2O/c1-17(21-8-4-6-19-5-2-3-7-22(19)21)29-13-11-20(12-14-29)25(30)28-16-18-9-10-23(26)24(27)15-18/h2-10,15,17,20H,11-14,16H2,1H3,(H,28,30)/t17-/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.40E+4	n/a	n/a	n/a	n/a	n/a	n/a
Purdue University Curated by ChEMBL					Assay Description Inhibition of human coronavirus NL63 PLP2 (amino acids 1565 to 1894) expressed in Escherichia coli BL21 (DE3) cells assessed as reduction of AMC rele...				J Med Chem 57: 2393-412 (2014) Article DOI: 10.1021/jm401712t BindingDB Entry DOI: 10.7270/Q2KK9DBM
					More data for this Ligand-Target Pair
Replicase polyprotein 1a (Human coronavirus NL63)	BDBM50007788 (CHEMBL3233809 | med.21724, Compound 167) Show SMILES C[C@@H](N1CCC(CC1)C(=O)NCc1cccc(NC(C)=O)c1)c1cccc2ccccc12 |r| Show InChI InChI=1S/C27H31N3O2/c1-19(25-12-6-9-22-8-3-4-11-26(22)25)30-15-13-23(14-16-30)27(32)28-18-21-7-5-10-24(17-21)29-20(2)31/h3-12,17,19,23H,13-16,18H2,1-2H3,(H,28,32)(H,29,31)/t19-/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	4.60E+4	n/a	n/a	n/a	n/a	n/a	n/a
Purdue University Curated by ChEMBL					Assay Description Inhibition of human coronavirus NL63 PLP2 (amino acids 1565 to 1894) expressed in Escherichia coli BL21 (DE3) cells assessed as reduction of AMC rele...				J Med Chem 57: 2393-412 (2014) Article DOI: 10.1021/jm401712t BindingDB Entry DOI: 10.7270/Q2KK9DBM
					More data for this Ligand-Target Pair
Replicase polyprotein 1a (Human coronavirus NL63)	BDBM50007794 (CHEMBL3233822) Show SMILES COc1cc(CNC(=O)C2CCN(CC2)[C@H](C)c2cccc3ccccc23)ccn1 |r| Show InChI InChI=1S/C25H29N3O2/c1-18(22-9-5-7-20-6-3-4-8-23(20)22)28-14-11-21(12-15-28)25(29)27-17-19-10-13-26-24(16-19)30-2/h3-10,13,16,18,21H,11-12,14-15,17H2,1-2H3,(H,27,29)/t18-/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5.90E+4	n/a	n/a	n/a	n/a	n/a	n/a
Purdue University Curated by ChEMBL					Assay Description Inhibition of human coronavirus NL63 PLP2 (amino acids 1565 to 1894) expressed in Escherichia coli BL21 (DE3) cells assessed as reduction of AMC rele...				J Med Chem 57: 2393-412 (2014) Article DOI: 10.1021/jm401712t BindingDB Entry DOI: 10.7270/Q2KK9DBM
					More data for this Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 8 (Homo sapiens (Human))	BDBM50007788 (CHEMBL3233809 | med.21724, Compound 167) Show SMILES C[C@@H](N1CCC(CC1)C(=O)NCc1cccc(NC(C)=O)c1)c1cccc2ccccc12 |r| Show InChI InChI=1S/C27H31N3O2/c1-19(25-12-6-9-22-8-3-4-11-26(22)25)30-15-13-23(14-16-30)27(32)28-18-21-7-5-10-24(17-21)29-20(2)31/h3-12,17,19,23H,13-16,18H2,1-2H3,(H,28,32)(H,29,31)/t19-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Purdue University Curated by ChEMBL					Assay Description Inhibition of human USP8 using Ub-rhodamine 110 as substrate				J Med Chem 57: 2393-412 (2014) Article DOI: 10.1021/jm401712t BindingDB Entry DOI: 10.7270/Q2KK9DBM
					More data for this Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 8 (Homo sapiens (Human))	BDBM50007789 (CHEMBL1173044 | GRL-0667 | N-(2H-1,3-benzodioxol-5...) Show SMILES C[C@@H](N1CCC(CC1)C(=O)NCc1ccc2OCOc2c1)c1cccc2ccccc12 |r| Show InChI InChI=1S/C26H28N2O3/c1-18(22-8-4-6-20-5-2-3-7-23(20)22)28-13-11-21(12-14-28)26(29)27-16-19-9-10-24-25(15-19)31-17-30-24/h2-10,15,18,21H,11-14,16-17H2,1H3,(H,27,29)/t18-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Purdue University Curated by ChEMBL					Assay Description Inhibition of human USP8 using Ub-rhodamine 110 as substrate				J Med Chem 57: 2393-412 (2014) Article DOI: 10.1021/jm401712t BindingDB Entry DOI: 10.7270/Q2KK9DBM
					More data for this Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 8 (Homo sapiens (Human))	BDBM50007791 (CHEMBL3233815 | med.21724, Compound 168) Show SMILES C[C@@H](N1CCC(CC1)C(=O)NCc1cccc(F)c1)c1cccc2ccccc12 |r| Show InChI InChI=1S/C25H27FN2O/c1-18(23-11-5-8-20-7-2-3-10-24(20)23)28-14-12-21(13-15-28)25(29)27-17-19-6-4-9-22(26)16-19/h2-11,16,18,21H,12-15,17H2,1H3,(H,27,29)/t18-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Purdue University Curated by ChEMBL					Assay Description Inhibition of human USP8 using Ub-rhodamine 110 as substrate				J Med Chem 57: 2393-412 (2014) Article DOI: 10.1021/jm401712t BindingDB Entry DOI: 10.7270/Q2KK9DBM
					More data for this Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 2 (Homo sapiens (Human))	BDBM50007788 (CHEMBL3233809 | med.21724, Compound 167) Show SMILES C[C@@H](N1CCC(CC1)C(=O)NCc1cccc(NC(C)=O)c1)c1cccc2ccccc12 |r| Show InChI InChI=1S/C27H31N3O2/c1-19(25-12-6-9-22-8-3-4-11-26(22)25)30-15-13-23(14-16-30)27(32)28-18-21-7-5-10-24(17-21)29-20(2)31/h3-12,17,19,23H,13-16,18H2,1-2H3,(H,28,32)(H,29,31)/t19-/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Purdue University Curated by ChEMBL					Assay Description Inhibition of human USP2 using Ub-rhodamine 110 as substrate				J Med Chem 57: 2393-412 (2014) Article DOI: 10.1021/jm401712t BindingDB Entry DOI: 10.7270/Q2KK9DBM
					More data for this Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 8 (Homo sapiens (Human))	BDBM50007790 (CHEMBL3233814 | med.21724, Compound 169) Show SMILES C[C@@H](N1CCC(CC1)C(=O)NCc1ccc(F)cc1)c1cccc2ccccc12 |r| Show InChI InChI=1S/C25H27FN2O/c1-18(23-8-4-6-20-5-2-3-7-24(20)23)28-15-13-21(14-16-28)25(29)27-17-19-9-11-22(26)12-10-19/h2-12,18,21H,13-17H2,1H3,(H,27,29)/t18-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Purdue University Curated by ChEMBL					Assay Description Inhibition of human USP8 using Ub-rhodamine 110 as substrate				J Med Chem 57: 2393-412 (2014) Article DOI: 10.1021/jm401712t BindingDB Entry DOI: 10.7270/Q2KK9DBM
					More data for this Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 20 (Homo sapiens (Human))	BDBM50007791 (CHEMBL3233815 | med.21724, Compound 168) Show SMILES C[C@@H](N1CCC(CC1)C(=O)NCc1cccc(F)c1)c1cccc2ccccc12 |r| Show InChI InChI=1S/C25H27FN2O/c1-18(23-11-5-8-20-7-2-3-10-24(20)23)28-14-12-21(13-15-28)25(29)27-17-19-6-4-9-22(26)16-19/h2-11,16,18,21H,12-15,17H2,1H3,(H,27,29)/t18-/m1/s1	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Purdue University Curated by ChEMBL					Assay Description Inhibition of human USP20 using Ub-rhodamine 110 as substrate				J Med Chem 57: 2393-412 (2014) Article DOI: 10.1021/jm401712t BindingDB Entry DOI: 10.7270/Q2KK9DBM
					More data for this Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 20 (Homo sapiens (Human))	BDBM50007790 (CHEMBL3233814 | med.21724, Compound 169) Show SMILES C[C@@H](N1CCC(CC1)C(=O)NCc1ccc(F)cc1)c1cccc2ccccc12 |r| Show InChI InChI=1S/C25H27FN2O/c1-18(23-8-4-6-20-5-2-3-7-24(20)23)28-15-13-21(14-16-28)25(29)27-17-19-9-11-22(26)12-10-19/h2-12,18,21H,13-17H2,1H3,(H,27,29)/t18-/m1/s1	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Purdue University Curated by ChEMBL					Assay Description Inhibition of human USP20 using Ub-rhodamine 110 as substrate				J Med Chem 57: 2393-412 (2014) Article DOI: 10.1021/jm401712t BindingDB Entry DOI: 10.7270/Q2KK9DBM
					More data for this Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 20 (Homo sapiens (Human))	BDBM50007788 (CHEMBL3233809 | med.21724, Compound 167) Show SMILES C[C@@H](N1CCC(CC1)C(=O)NCc1cccc(NC(C)=O)c1)c1cccc2ccccc12 |r| Show InChI InChI=1S/C27H31N3O2/c1-19(25-12-6-9-22-8-3-4-11-26(22)25)30-15-13-23(14-16-30)27(32)28-18-21-7-5-10-24(17-21)29-20(2)31/h3-12,17,19,23H,13-16,18H2,1-2H3,(H,28,32)(H,29,31)/t19-/m1/s1	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Purdue University Curated by ChEMBL					Assay Description Inhibition of human USP20 using Ub-rhodamine 110 as substrate				J Med Chem 57: 2393-412 (2014) Article DOI: 10.1021/jm401712t BindingDB Entry DOI: 10.7270/Q2KK9DBM
					More data for this Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 7 (Homo sapiens (Human))	BDBM50007788 (CHEMBL3233809 | med.21724, Compound 167) Show SMILES C[C@@H](N1CCC(CC1)C(=O)NCc1cccc(NC(C)=O)c1)c1cccc2ccccc12 |r| Show InChI InChI=1S/C27H31N3O2/c1-19(25-12-6-9-22-8-3-4-11-26(22)25)30-15-13-23(14-16-30)27(32)28-18-21-7-5-10-24(17-21)29-20(2)31/h3-12,17,19,23H,13-16,18H2,1-2H3,(H,28,32)(H,29,31)/t19-/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Purdue University Curated by ChEMBL					Assay Description Inhibition of human USP7 using Ub-rhodamine 110 as substrate				J Med Chem 57: 2393-412 (2014) Article DOI: 10.1021/jm401712t BindingDB Entry DOI: 10.7270/Q2KK9DBM
					More data for this Ligand-Target Pair