Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
TGF-beta receptor type-1 (Homo sapiens (Human)) | BDBM50184486 (1-methyl-6-(2-pyridin-2-yl-5,6-dihydro-4H-pyrrolo[...) | PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 8 | n/a | n/a | n/a | n/a | n/a | n/a |
Lilly Research Laboratory Curated by ChEMBL | Assay Description Inhibition of TGFbeta R1 induced transcriptional activation of p3TP-Lux in mink Mv1Lu lung cells | J Med Chem 49: 2138-42 (2006) Article DOI: 10.1021/jm058209g BindingDB Entry DOI: 10.7270/Q2V40TS0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
TGF-beta receptor type-1 (Homo sapiens (Human)) | BDBM50184488 (6-[2-(6-methyl-pyridin-2-yl)-5,6-dihydro-4H-pyrrol...) | PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 15 | n/a | n/a | n/a | n/a | n/a | n/a |
Lilly Research Laboratory Curated by ChEMBL | Assay Description Inhibition of TGFbeta R1 induced transcriptional activation of p3TP-Lux in mink Mv1Lu lung cells | J Med Chem 49: 2138-42 (2006) Article DOI: 10.1021/jm058209g BindingDB Entry DOI: 10.7270/Q2V40TS0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
TGF-beta receptor type-1 (Homo sapiens (Human)) | BDBM50184483 (1-methyl-6-[2-(6-methylpyridin-2-yl)-5,6-dihydro-4...) | PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 22 | n/a | n/a | n/a | n/a | n/a | n/a |
Lilly Research Laboratory Curated by ChEMBL | Assay Description Inhibition of recombinant human TGFbeta R1 expressed in Sf9 cells | J Med Chem 49: 2138-42 (2006) Article DOI: 10.1021/jm058209g BindingDB Entry DOI: 10.7270/Q2V40TS0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
TGF-beta receptor type-1 [4-503,T204D] (Homo sapiens (Human)) | BDBM21506 (Dihydropyrrolopyrazole, 15a | dimethyl[2-({4-[2-(p...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 24 | n/a | 29 | n/a | n/a | 7.5 | 30 |
Lilly Research Laboratories | Assay Description The kinase activity was assayed by the autophosphorylation reaction of ALK5 (T204D) in the presence of 4 uM ATP and [33P]-gamma-ATP. After incubation... | J Med Chem 51: 2302-2306 (2008) Article DOI: 10.1021/jm701199p BindingDB Entry DOI: 10.7270/Q2G15Z4K | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
TGF-beta receptor type-1 (Homo sapiens (Human)) | BDBM50184483 (1-methyl-6-[2-(6-methylpyridin-2-yl)-5,6-dihydro-4...) | PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 29 | n/a | n/a | n/a | n/a | n/a | n/a |
Lilly Research Laboratory Curated by ChEMBL | Assay Description Inhibition of TGFbeta R1 induced transcriptional activation of p3TP-Lux in mink Mv1Lu lung cells | J Med Chem 49: 2138-42 (2006) Article DOI: 10.1021/jm058209g BindingDB Entry DOI: 10.7270/Q2V40TS0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
TGF-beta receptor type-1 [4-503,T204D] (Homo sapiens (Human)) | BDBM21505 (7-(2-chloroethoxy)-4-[2-(pyridin-2-yl)-4H,5H,6H-py...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 33 | n/a | 66 | n/a | n/a | 7.5 | 30 |
Lilly Research Laboratories | Assay Description The kinase activity was assayed by the autophosphorylation reaction of ALK5 (T204D) in the presence of 4 uM ATP and [33P]-gamma-ATP. After incubation... | J Med Chem 51: 2302-2306 (2008) Article DOI: 10.1021/jm701199p BindingDB Entry DOI: 10.7270/Q2G15Z4K | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
TGF-beta receptor type-1 (Homo sapiens (Human)) | BDBM21492 (4-[3-(pyridin-2-yl)-1H-pyrazol-4-yl]quinoline | CH...) | PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 40 | n/a | n/a | n/a | n/a | n/a | n/a |
Lilly Research Laboratory Curated by ChEMBL | Assay Description Inhibition of TGFbeta R1 induced transcriptional activation of p3TP-Lux in mink Mv1Lu lung cells | J Med Chem 49: 2138-42 (2006) Article DOI: 10.1021/jm058209g BindingDB Entry DOI: 10.7270/Q2V40TS0 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
TGF-beta receptor type-1 (Homo sapiens (Human)) | BDBM50184489 (3-(6-(2-(6-methylpyridin-2-yl)-5,6-dihydro-4H-pyrr...) | PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 41 | n/a | n/a | n/a | n/a | n/a | n/a |
Lilly Research Laboratory Curated by ChEMBL | Assay Description Inhibition of recombinant human TGFbeta R1 expressed in Sf9 cells | J Med Chem 49: 2138-42 (2006) Article DOI: 10.1021/jm058209g BindingDB Entry DOI: 10.7270/Q2V40TS0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
TGF-beta receptor type-1 (Homo sapiens (Human)) | BDBM50184488 (6-[2-(6-methyl-pyridin-2-yl)-5,6-dihydro-4H-pyrrol...) | PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 47 | n/a | n/a | n/a | n/a | n/a | n/a |
Lilly Research Laboratory Curated by ChEMBL | Assay Description Inhibition of recombinant human TGFbeta R1 expressed in Sf9 cells | J Med Chem 49: 2138-42 (2006) Article DOI: 10.1021/jm058209g BindingDB Entry DOI: 10.7270/Q2V40TS0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
TGF-beta receptor type-1 [4-503,T204D] (Homo sapiens (Human)) | BDBM21510 (Dihydropyrrolopyrazole, 16a | dimethyl[5-({4-[2-(p...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 47 | n/a | 24 | n/a | n/a | 7.5 | 30 |
Lilly Research Laboratories | Assay Description The kinase activity was assayed by the autophosphorylation reaction of ALK5 (T204D) in the presence of 4 uM ATP and [33P]-gamma-ATP. After incubation... | J Med Chem 51: 2302-2306 (2008) Article DOI: 10.1021/jm701199p BindingDB Entry DOI: 10.7270/Q2G15Z4K | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
TGF-beta receptor type-1 [4-503,T204D] (Homo sapiens (Human)) | BDBM21511 (1-(4-methylpiperazin-1-yl)-2-({4-[2-(pyridin-2-yl)...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 49 | n/a | 260 | n/a | n/a | 7.5 | 30 |
Lilly Research Laboratories | Assay Description The kinase activity was assayed by the autophosphorylation reaction of ALK5 (T204D) in the presence of 4 uM ATP and [33P]-gamma-ATP. After incubation... | J Med Chem 51: 2302-2306 (2008) Article DOI: 10.1021/jm701199p BindingDB Entry DOI: 10.7270/Q2G15Z4K | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
TGF-beta receptor type-1 (Homo sapiens (Human)) | BDBM50184494 (6-[2-(6-methyl-pyridin-2-yl)-5,6-dihydro-4H-pyrrol...) | PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 51 | n/a | n/a | n/a | n/a | n/a | n/a |
Lilly Research Laboratory Curated by ChEMBL | Assay Description Inhibition of TGFbeta R1 induced transcriptional activation of p3TP-Lux in mink Mv1Lu lung cells | J Med Chem 49: 2138-42 (2006) Article DOI: 10.1021/jm058209g BindingDB Entry DOI: 10.7270/Q2V40TS0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
TGF-beta receptor type-1 (Homo sapiens (Human)) | BDBM50184496 (CHEMBL441176 | dimethyl-(3-{6-[2-(6-methyl-pyridin...) | PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 53 | n/a | n/a | n/a | n/a | n/a | n/a |
Lilly Research Laboratory Curated by ChEMBL | Assay Description Inhibition of TGFbeta R1 induced transcriptional activation of p3TP-Lux in mink Mv1Lu lung cells | J Med Chem 49: 2138-42 (2006) Article DOI: 10.1021/jm058209g BindingDB Entry DOI: 10.7270/Q2V40TS0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
TGF-beta receptor type-1 [4-503,T204D] (Homo sapiens (Human)) | BDBM21492 (4-[3-(pyridin-2-yl)-1H-pyrazol-4-yl]quinoline | CH...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 59 | n/a | 40 | n/a | n/a | 7.5 | 30 |
Lilly Research Laboratories | Assay Description The kinase activity was assayed by the autophosphorylation reaction of ALK5 (T204D) in the presence of 4 uM ATP and [33P]-gamma-ATP. After incubation... | J Med Chem 51: 2302-2306 (2008) Article DOI: 10.1021/jm701199p BindingDB Entry DOI: 10.7270/Q2G15Z4K | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
TGF-beta receptor type-1 (Homo sapiens (Human)) | BDBM21492 (4-[3-(pyridin-2-yl)-1H-pyrazol-4-yl]quinoline | CH...) | PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 59 | n/a | n/a | n/a | n/a | n/a | n/a |
Lilly Research Laboratory Curated by ChEMBL | Assay Description Inhibition of recombinant human TGFbeta R1 expressed in Sf9 cells | J Med Chem 49: 2138-42 (2006) Article DOI: 10.1021/jm058209g BindingDB Entry DOI: 10.7270/Q2V40TS0 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
TGF-beta receptor type-1 [4-503,T204D] (Homo sapiens (Human)) | BDBM21509 (4-[2-({4-[2-(pyridin-2-yl)-4H,5H,6H-pyrrolo[1,2-a]...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 69 | n/a | 180 | n/a | n/a | 7.5 | 30 |
Lilly Research Laboratories | Assay Description The kinase activity was assayed by the autophosphorylation reaction of ALK5 (T204D) in the presence of 4 uM ATP and [33P]-gamma-ATP. After incubation... | J Med Chem 51: 2302-2306 (2008) Article DOI: 10.1021/jm701199p BindingDB Entry DOI: 10.7270/Q2G15Z4K | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
TGF-beta receptor type-1 (Homo sapiens (Human)) | BDBM50184487 (4-(3-(6-(2-(6-methylpyridin-2-yl)-5,6-dihydro-4H-p...) | PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 69 | n/a | n/a | n/a | n/a | n/a | n/a |
Lilly Research Laboratory Curated by ChEMBL | Assay Description Inhibition of recombinant human TGFbeta R1 expressed in Sf9 cells | J Med Chem 49: 2138-42 (2006) Article DOI: 10.1021/jm058209g BindingDB Entry DOI: 10.7270/Q2V40TS0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
TGF-beta receptor type-1 [4-503,T204D] (Homo sapiens (Human)) | BDBM21513 (7-[3-(1-methylpyrrolidin-2-yl)propoxy]-4-[2-(pyrid...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 72 | n/a | 17 | n/a | n/a | 7.5 | 30 |
Lilly Research Laboratories | Assay Description The kinase activity was assayed by the autophosphorylation reaction of ALK5 (T204D) in the presence of 4 uM ATP and [33P]-gamma-ATP. After incubation... | J Med Chem 51: 2302-2306 (2008) Article DOI: 10.1021/jm701199p BindingDB Entry DOI: 10.7270/Q2G15Z4K | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
TGF-beta receptor type-1 (Homo sapiens (Human)) | BDBM50184497 (6-[2-(6-methyl-pyridin-2-yl)-5,6-dihydro-4H-pyrrol...) | PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 74 | n/a | n/a | n/a | n/a | n/a | n/a |
Lilly Research Laboratory Curated by ChEMBL | Assay Description Inhibition of recombinant human TGFbeta R1 expressed in Sf9 cells | J Med Chem 49: 2138-42 (2006) Article DOI: 10.1021/jm058209g BindingDB Entry DOI: 10.7270/Q2V40TS0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
TGF-beta receptor type-1 [4-503,T204D] (Homo sapiens (Human)) | BDBM21504 (7-[3-(4-methylpiperazin-1-yl)propoxy]-4-[2-(pyridi...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 74 | n/a | 44 | n/a | n/a | 7.5 | 30 |
Lilly Research Laboratories | Assay Description The kinase activity was assayed by the autophosphorylation reaction of ALK5 (T204D) in the presence of 4 uM ATP and [33P]-gamma-ATP. After incubation... | J Med Chem 51: 2302-2306 (2008) Article DOI: 10.1021/jm701199p BindingDB Entry DOI: 10.7270/Q2G15Z4K | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
TGF-beta receptor type-1 (Homo sapiens (Human)) | BDBM50184486 (1-methyl-6-(2-pyridin-2-yl-5,6-dihydro-4H-pyrrolo[...) | PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 75 | n/a | n/a | n/a | n/a | n/a | n/a |
Lilly Research Laboratory Curated by ChEMBL | Assay Description Inhibition of recombinant human TGFbeta R1 expressed in Sf9 cells | J Med Chem 49: 2138-42 (2006) Article DOI: 10.1021/jm058209g BindingDB Entry DOI: 10.7270/Q2V40TS0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
TGF-beta receptor type-1 (Homo sapiens (Human)) | BDBM50184489 (3-(6-(2-(6-methylpyridin-2-yl)-5,6-dihydro-4H-pyrr...) | PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 78 | n/a | n/a | n/a | n/a | n/a | n/a |
Lilly Research Laboratory Curated by ChEMBL | Assay Description Inhibition of TGFbeta R1 induced transcriptional activation of p3TP-Lux in mink Mv1Lu lung cells | J Med Chem 49: 2138-42 (2006) Article DOI: 10.1021/jm058209g BindingDB Entry DOI: 10.7270/Q2V40TS0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
TGF-beta receptor type-1 (Homo sapiens (Human)) | BDBM50184490 (3-[6-(2-pyridin-2-yl-5,6-dihydro-4H-pyrrolo[1,2-b]...) | PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 79 | n/a | n/a | n/a | n/a | n/a | n/a |
Lilly Research Laboratory Curated by ChEMBL | Assay Description Inhibition of TGFbeta R1 induced transcriptional activation of p3TP-Lux in mink Mv1Lu lung cells | J Med Chem 49: 2138-42 (2006) Article DOI: 10.1021/jm058209g BindingDB Entry DOI: 10.7270/Q2V40TS0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
TGF-beta receptor type-1 (Homo sapiens (Human)) | BDBM50184490 (3-[6-(2-pyridin-2-yl-5,6-dihydro-4H-pyrrolo[1,2-b]...) | PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 79 | n/a | n/a | n/a | n/a | n/a | n/a |
Lilly Research Laboratory Curated by ChEMBL | Assay Description Inhibition of recombinant human TGFbeta R1 expressed in Sf9 cells | J Med Chem 49: 2138-42 (2006) Article DOI: 10.1021/jm058209g BindingDB Entry DOI: 10.7270/Q2V40TS0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
TGF-beta receptor type-1 [4-503,T204D] (Homo sapiens (Human)) | BDBM21507 (Dihydropyrrolopyrazole, 15b | ethyl(methyl)[2-({4-...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 85 | n/a | 61 | n/a | n/a | 7.5 | 30 |
Lilly Research Laboratories | Assay Description The kinase activity was assayed by the autophosphorylation reaction of ALK5 (T204D) in the presence of 4 uM ATP and [33P]-gamma-ATP. After incubation... | J Med Chem 51: 2302-2306 (2008) Article DOI: 10.1021/jm701199p BindingDB Entry DOI: 10.7270/Q2G15Z4K | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
TGF-beta receptor type-1 (Homo sapiens (Human)) | BDBM50184496 (CHEMBL441176 | dimethyl-(3-{6-[2-(6-methyl-pyridin...) | PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 85 | n/a | n/a | n/a | n/a | n/a | n/a |
Lilly Research Laboratory Curated by ChEMBL | Assay Description Inhibition of recombinant human TGFbeta R1 expressed in Sf9 cells | J Med Chem 49: 2138-42 (2006) Article DOI: 10.1021/jm058209g BindingDB Entry DOI: 10.7270/Q2V40TS0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
TGF-beta receptor type-1 [4-503,T204D] (Homo sapiens (Human)) | BDBM21496 (6-bromo-4-[2-(6-methylpyridin-2-yl)-4H,5H,6H-pyrro...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 89 | n/a | 55 | n/a | n/a | 7.5 | 30 |
Lilly Research Laboratories | Assay Description The kinase activity was assayed by the autophosphorylation reaction of ALK5 (T204D) in the presence of 4 uM ATP and [33P]-gamma-ATP. After incubation... | J Med Chem 51: 2302-2306 (2008) Article DOI: 10.1021/jm701199p BindingDB Entry DOI: 10.7270/Q2G15Z4K | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
TGF-beta receptor type-1 [4-503,T204D] (Homo sapiens (Human)) | BDBM21508 (7-[2-(4-methylpiperazin-1-yl)ethoxy]-4-[2-(pyridin...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 100 | n/a | 38 | n/a | n/a | 7.5 | 30 |
Lilly Research Laboratories | Assay Description The kinase activity was assayed by the autophosphorylation reaction of ALK5 (T204D) in the presence of 4 uM ATP and [33P]-gamma-ATP. After incubation... | J Med Chem 51: 2302-2306 (2008) Article DOI: 10.1021/jm701199p BindingDB Entry DOI: 10.7270/Q2G15Z4K | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
TGF-beta receptor type-1 (Homo sapiens (Human)) | BDBM50184493 (CHEMBL203791 | N,N-diethyl-3-(6-(2-(6-methylpyridi...) | PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 100 | n/a | n/a | n/a | n/a | n/a | n/a |
Lilly Research Laboratory Curated by ChEMBL | Assay Description Inhibition of TGFbeta R1 induced transcriptional activation of p3TP-Lux in mink Mv1Lu lung cells | J Med Chem 49: 2138-42 (2006) Article DOI: 10.1021/jm058209g BindingDB Entry DOI: 10.7270/Q2V40TS0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
TGF-beta receptor type-1 (Homo sapiens (Human)) | BDBM50184480 (CHEMBL202730 | dimethyl-{3-[6-(2-pyridin-2-yl-5,6-...) | PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 104 | n/a | n/a | n/a | n/a | n/a | n/a |
Lilly Research Laboratory Curated by ChEMBL | Assay Description Inhibition of TGFbeta R1 induced transcriptional activation of p3TP-Lux in mink Mv1Lu lung cells | J Med Chem 49: 2138-42 (2006) Article DOI: 10.1021/jm058209g BindingDB Entry DOI: 10.7270/Q2V40TS0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
TGF-beta receptor type-1 (Homo sapiens (Human)) | BDBM50184497 (6-[2-(6-methyl-pyridin-2-yl)-5,6-dihydro-4H-pyrrol...) | PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 117 | n/a | n/a | n/a | n/a | n/a | n/a |
Lilly Research Laboratory Curated by ChEMBL | Assay Description Inhibition of TGFbeta R1 induced transcriptional activation of p3TP-Lux in mink Mv1Lu lung cells | J Med Chem 49: 2138-42 (2006) Article DOI: 10.1021/jm058209g BindingDB Entry DOI: 10.7270/Q2V40TS0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
TGF-beta receptor type-1 (Homo sapiens (Human)) | BDBM50184493 (CHEMBL203791 | N,N-diethyl-3-(6-(2-(6-methylpyridi...) | PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 122 | n/a | n/a | n/a | n/a | n/a | n/a |
Lilly Research Laboratory Curated by ChEMBL | Assay Description Inhibition of recombinant human TGFbeta R1 expressed in Sf9 cells | J Med Chem 49: 2138-42 (2006) Article DOI: 10.1021/jm058209g BindingDB Entry DOI: 10.7270/Q2V40TS0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
TGF-beta receptor type-1 [4-503,T204D] (Homo sapiens (Human)) | BDBM21512 (7-(oxolan-2-ylmethoxy)-4-[2-(pyridin-2-yl)-4H,5H,6...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 130 | n/a | 80 | n/a | n/a | 7.5 | 30 |
Lilly Research Laboratories | Assay Description The kinase activity was assayed by the autophosphorylation reaction of ALK5 (T204D) in the presence of 4 uM ATP and [33P]-gamma-ATP. After incubation... | J Med Chem 51: 2302-2306 (2008) Article DOI: 10.1021/jm701199p BindingDB Entry DOI: 10.7270/Q2G15Z4K | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
TGF-beta receptor type-1 [4-503,T204D] (Homo sapiens (Human)) | BDBM21497 (4-[2-(6-methylpyridin-2-yl)-4H,5H,6H-pyrrolo[1,2-a...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 141 | n/a | 201 | n/a | n/a | 7.5 | 30 |
Lilly Research Laboratories | Assay Description The kinase activity was assayed by the autophosphorylation reaction of ALK5 (T204D) in the presence of 4 uM ATP and [33P]-gamma-ATP. After incubation... | J Med Chem 51: 2302-2306 (2008) Article DOI: 10.1021/jm701199p BindingDB Entry DOI: 10.7270/Q2G15Z4K | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
TGF-beta receptor type-1 (Homo sapiens (Human)) | BDBM50184494 (6-[2-(6-methyl-pyridin-2-yl)-5,6-dihydro-4H-pyrrol...) | PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 155 | n/a | n/a | n/a | n/a | n/a | n/a |
Lilly Research Laboratory Curated by ChEMBL | Assay Description Inhibition of recombinant human TGFbeta R1 expressed in Sf9 cells | J Med Chem 49: 2138-42 (2006) Article DOI: 10.1021/jm058209g BindingDB Entry DOI: 10.7270/Q2V40TS0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
TGF-beta receptor type-1 [4-503,T204D] (Homo sapiens (Human)) | BDBM21503 (4-[2-(pyridin-2-yl)-4H,5H,6H-pyrrolo[1,2-a]pyrazol...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 160 | n/a | 200 | n/a | n/a | 7.5 | 30 |
Lilly Research Laboratories | Assay Description The kinase activity was assayed by the autophosphorylation reaction of ALK5 (T204D) in the presence of 4 uM ATP and [33P]-gamma-ATP. After incubation... | J Med Chem 51: 2302-2306 (2008) Article DOI: 10.1021/jm701199p BindingDB Entry DOI: 10.7270/Q2G15Z4K | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
TGF-beta receptor type-1 (Homo sapiens (Human)) | BDBM50184487 (4-(3-(6-(2-(6-methylpyridin-2-yl)-5,6-dihydro-4H-p...) | PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 186 | n/a | n/a | n/a | n/a | n/a | n/a |
Lilly Research Laboratory Curated by ChEMBL | Assay Description Inhibition of TGFbeta R1 induced transcriptional activation of p3TP-Lux in mink Mv1Lu lung cells | J Med Chem 49: 2138-42 (2006) Article DOI: 10.1021/jm058209g BindingDB Entry DOI: 10.7270/Q2V40TS0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
TGF-beta receptor type-1 [4-503,T204D] (Homo sapiens (Human)) | BDBM21499 (Dihydropyrrolopyrazole, 9 | N-[2-(dimethylamino)et...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 193 | n/a | 468 | n/a | n/a | 7.5 | 30 |
Lilly Research Laboratories | Assay Description The kinase activity was assayed by the autophosphorylation reaction of ALK5 (T204D) in the presence of 4 uM ATP and [33P]-gamma-ATP. After incubation... | J Med Chem 51: 2302-2306 (2008) Article DOI: 10.1021/jm701199p BindingDB Entry DOI: 10.7270/Q2G15Z4K | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
TGF-beta receptor type-1 (Homo sapiens (Human)) | BDBM50184491 (6-(2-(pyridin-2-yl)-5,6-dihydro-4H-pyrrolo[1,2-b]p...) | PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 226 | n/a | n/a | n/a | n/a | n/a | n/a |
Lilly Research Laboratory Curated by ChEMBL | Assay Description Inhibition of TGFbeta R1 induced transcriptional activation of p3TP-Lux in mink Mv1Lu lung cells | J Med Chem 49: 2138-42 (2006) Article DOI: 10.1021/jm058209g BindingDB Entry DOI: 10.7270/Q2V40TS0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
TGF-beta receptor type-1 (Homo sapiens (Human)) | BDBM50184491 (6-(2-(pyridin-2-yl)-5,6-dihydro-4H-pyrrolo[1,2-b]p...) | PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 246 | n/a | n/a | n/a | n/a | n/a | n/a |
Lilly Research Laboratory Curated by ChEMBL | Assay Description Inhibition of recombinant human TGFbeta R1 expressed in Sf9 cells | J Med Chem 49: 2138-42 (2006) Article DOI: 10.1021/jm058209g BindingDB Entry DOI: 10.7270/Q2V40TS0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
TGF-beta receptor type-2 (Homo sapiens (Human)) | BDBM50184490 (3-[6-(2-pyridin-2-yl-5,6-dihydro-4H-pyrrolo[1,2-b]...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 352 | n/a | n/a | n/a | n/a | n/a | n/a |
Lilly Research Laboratory Curated by ChEMBL | Assay Description Inhibition of recombinant human TGFbeta R2 expressed in Sf9 cells | J Med Chem 49: 2138-42 (2006) Article DOI: 10.1021/jm058209g BindingDB Entry DOI: 10.7270/Q2V40TS0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
TGF-beta receptor type-2 (Homo sapiens (Human)) | BDBM50184486 (1-methyl-6-(2-pyridin-2-yl-5,6-dihydro-4H-pyrrolo[...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 395 | n/a | n/a | n/a | n/a | n/a | n/a |
Lilly Research Laboratory Curated by ChEMBL | Assay Description Inhibition of recombinant human TGFbeta R2 expressed in Sf9 cells | J Med Chem 49: 2138-42 (2006) Article DOI: 10.1021/jm058209g BindingDB Entry DOI: 10.7270/Q2V40TS0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
TGF-beta receptor type-1 (Homo sapiens (Human)) | BDBM50184480 (CHEMBL202730 | dimethyl-{3-[6-(2-pyridin-2-yl-5,6-...) | PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 398 | n/a | n/a | n/a | n/a | n/a | n/a |
Lilly Research Laboratory Curated by ChEMBL | Assay Description Inhibition of recombinant human TGFbeta R1 expressed in Sf9 cells | J Med Chem 49: 2138-42 (2006) Article DOI: 10.1021/jm058209g BindingDB Entry DOI: 10.7270/Q2V40TS0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
TGF-beta receptor type-2 (Homo sapiens (Human)) | BDBM21492 (4-[3-(pyridin-2-yl)-1H-pyrazol-4-yl]quinoline | CH...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 400 | n/a | n/a | n/a | n/a | n/a | n/a |
Lilly Research Laboratory Curated by ChEMBL | Assay Description Inhibition of recombinant human TGFbeta R2 expressed in Sf9 cells | J Med Chem 49: 2138-42 (2006) Article DOI: 10.1021/jm058209g BindingDB Entry DOI: 10.7270/Q2V40TS0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
TGF-beta receptor type-1 (Homo sapiens (Human)) | BDBM50184492 (5-(2-(pyridin-2-yl)-5,6-dihydro-4H-pyrrolo[1,2-b]p...) | PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 422 | n/a | n/a | n/a | n/a | n/a | n/a |
Lilly Research Laboratory Curated by ChEMBL | Assay Description Inhibition of TGFbeta R1 induced transcriptional activation of p3TP-Lux in mink Mv1Lu lung cells | J Med Chem 49: 2138-42 (2006) Article DOI: 10.1021/jm058209g BindingDB Entry DOI: 10.7270/Q2V40TS0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
TGF-beta receptor type-1 [4-503,T204D] (Homo sapiens (Human)) | BDBM21498 (Dihydropyrrolopyrazole, 8 | methyl 4-[2-(6-methylp...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 526 | n/a | 403 | n/a | n/a | 7.5 | 30 |
Lilly Research Laboratories | Assay Description The kinase activity was assayed by the autophosphorylation reaction of ALK5 (T204D) in the presence of 4 uM ATP and [33P]-gamma-ATP. After incubation... | J Med Chem 51: 2302-2306 (2008) Article DOI: 10.1021/jm701199p BindingDB Entry DOI: 10.7270/Q2G15Z4K | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
TGF-beta receptor type-2 (Homo sapiens (Human)) | BDBM50184483 (1-methyl-6-[2-(6-methylpyridin-2-yl)-5,6-dihydro-4...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 668 | n/a | n/a | n/a | n/a | n/a | n/a |
Lilly Research Laboratory Curated by ChEMBL | Assay Description Inhibition of recombinant human TGFbeta R2 expressed in Sf9 cells | J Med Chem 49: 2138-42 (2006) Article DOI: 10.1021/jm058209g BindingDB Entry DOI: 10.7270/Q2V40TS0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
TGF-beta receptor type-2 (Homo sapiens (Human)) | BDBM50184489 (3-(6-(2-(6-methylpyridin-2-yl)-5,6-dihydro-4H-pyrr...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 690 | n/a | n/a | n/a | n/a | n/a | n/a |
Lilly Research Laboratory Curated by ChEMBL | Assay Description Inhibition of recombinant human TGFbeta R2 expressed in Sf9 cells | J Med Chem 49: 2138-42 (2006) Article DOI: 10.1021/jm058209g BindingDB Entry DOI: 10.7270/Q2V40TS0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mitogen-activated protein kinase kinase kinase 20 (Homo sapiens (Human)) | BDBM50184490 (3-[6-(2-pyridin-2-yl-5,6-dihydro-4H-pyrrolo[1,2-b]...) | PDB NCI pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 708 | n/a | n/a | n/a | n/a | n/a | n/a |
Lilly Research Laboratory Curated by ChEMBL | Assay Description Inhibition of MLK7 | J Med Chem 49: 2138-42 (2006) Article DOI: 10.1021/jm058209g BindingDB Entry DOI: 10.7270/Q2V40TS0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
TGF-beta receptor type-1 [4-503,T204D] (Homo sapiens (Human)) | BDBM21518 (Dihydropyrrolopyrazole, 23 | dimethyl({[4-({4-[2-(...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 750 | n/a | n/a | n/a | n/a | 7.5 | 30 |
Lilly Research Laboratories | Assay Description The kinase activity was assayed by the autophosphorylation reaction of ALK5 (T204D) in the presence of 4 uM ATP and [33P]-gamma-ATP. After incubation... | J Med Chem 51: 2302-2306 (2008) Article DOI: 10.1021/jm701199p BindingDB Entry DOI: 10.7270/Q2G15Z4K | |||||||||||
More data for this Ligand-Target Pair |
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