| Reaction Details |
|---|
 | Report a problem with these data |
| Target | TGF-beta receptor type-2 |
|---|
| Ligand | BDBM21492 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_337603 (CHEMBL861563) |
|---|
| IC50 | 400±n/a nM |
|---|
| Citation |  Li, HY; Wang, Y; Heap, CR; King, CH; Mundla, SR; Voss, M; Clawson, DK; Yan, L; Campbell, RM; Anderson, BD; Wagner, JR; Britt, K; Lu, KX; McMillen, WT; Yingling, JM Dihydropyrrolopyrazole transforming growth factor-beta type I receptor kinase domain inhibitors: a novel benzimidazole series with selectivity versus transforming growth factor-beta type II receptor kinase and mixed lineage kinase-7. J Med Chem49:2138-42 (2006) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| TGF-beta receptor type-2 |
|---|
| Name: | TGF-beta receptor type-2 |
|---|
| Synonyms: | TGF-beta receptor type II | TGFBR2 | TGFR2_HUMAN |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 64559.49 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ChEMBL_586859 |
|---|
| Residue: | 567 |
|---|
| Sequence: | MGRGLLRGLWPLHIVLWTRIASTIPPHVQKSVNNDMIVTDNNGAVKFPQLCKFCDVRFST
CDNQKSCMSNCSITSICEKPQEVCVAVWRKNDENITLETVCHDPKLPYHDFILEDAASPK
CIMKEKKKPGETFFMCSCSSDECNDNIIFSEEYNTSNPDLLLVIFQVTGISLLPPLGVAI
SVIIIFYCYRVNRQQKLSSTWETGKTRKLMEFSEHCAIILEDDRSDISSTCANNINHNTE
LLPIELDTLVGKGRFAEVYKAKLKQNTSEQFETVAVKIFPYEEYASWKTEKDIFSDINLK
HENILQFLTAEERKTELGKQYWLITAFHAKGNLQEYLTRHVISWEDLRKLGSSLARGIAH
LHSDHTPCGRPKMPIVHRDLKSSNILVKNDLTCCLCDFGLSLRLDPTLSVDDLANSGQVG
TARYMAPEVLESRMNLENVESFKQTDVYSMALVLWEMTSRCNAVGEVKDYEPPFGSKVRE
HPCVESMKDNVLRDRGRPEIPSFWLNHQGIQMVCETLTECWDHDPEARLTAQCVAERFSE
LEHLDRLSGRSCSEEKIPEDGSLNTTK
|
|
|
|---|
| BDBM21492 |
|---|
| n/a |
|---|
| Name | BDBM21492 |
|---|
| Synonyms: | 4-[3-(pyridin-2-yl)-1H-pyrazol-4-yl]quinoline | CHEMBL261454 | LY364947 | US11759530, Compound Table1.1 | US9138393, LY-364947 | US9144538, LY-364947 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C17H12N4 |
|---|
| Mol. Mass. | 272.304 |
|---|
| SMILES | c1[nH]nc(c1-c1ccnc2ccccc12)-c1ccccn1 |
|---|
| Structure | 
|
|---|
Search and Browse
