Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Sodium-dependent dopamine transporter (Rattus norvegicus (rat)) | BDBM50062680 (2-[[2-[[[3-(4-chlorophenyl)-8-methyl-8-azabicyclo[...) | Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC sid UniChem Similars | Article PubMed | 8.42 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Pennsylvania Curated by ChEMBL | Assay Description In vitro bindingaffinity towards dopamine transporter in rat striatal homogenatewith [125I]-IPT as the radioligand | J Med Chem 41: 428-36 (1998) Article DOI: 10.1021/jm970742b BindingDB Entry DOI: 10.7270/Q2DN4459 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium-dependent dopamine transporter (Rattus norvegicus (rat)) | BDBM50062679 (2-[[2-[[[3-(4-chlorophenyl)-8-methyl-8-azabicyclo[...) | Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC sid UniChem Similars | Article PubMed | 13.9 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Pennsylvania Curated by ChEMBL | Assay Description In vitro bindingaffinity towards dopamine transporter in rat striatal homogenatewith [125I]-IPT as the radioligand | J Med Chem 41: 428-36 (1998) Article DOI: 10.1021/jm970742b BindingDB Entry DOI: 10.7270/Q2DN4459 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
DNA polymerase alpha catalytic subunit (Homo sapiens (Human)) | BDBM50236025 (CHEMBL2016761 | US11149049, No. C2) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE KEGG PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | >2.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Gilead Sciences, Inc. Curated by ChEMBL | Assay Description Inhibition of recombinant human DNA polymerase alpha preincubated with enzyme followed by addition of dATP/dGTP/TTP as substrate in presence of [gamm... | J Med Chem 60: 1648-1661 (2017) Article DOI: 10.1021/acs.jmedchem.6b01594 BindingDB Entry DOI: 10.7270/Q2QZ2D7N | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
DNA polymerase beta (Homo sapiens (Human)) | BDBM50236025 (CHEMBL2016761 | US11149049, No. C2) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE KEGG PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | >2.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Gilead Sciences, Inc. Curated by ChEMBL | Assay Description Inhibition of recombinant human DNA polymerase beta preincubated with enzyme followed by addition of dATP/dGTP/TTP as substrate in presence of [gamma... | J Med Chem 60: 1648-1661 (2017) Article DOI: 10.1021/acs.jmedchem.6b01594 BindingDB Entry DOI: 10.7270/Q2QZ2D7N | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
DNA-directed RNA polymerase, mitochondrial (Homo sapiens (Human)) | BDBM50236025 (CHEMBL2016761 | US11149049, No. C2) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL MCE KEGG PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | >2.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Gilead Sciences, Inc. Curated by ChEMBL | Assay Description Inhibition of human mitochondrial RNA polymerase after 30 mins in presence of [33P]GTP | J Med Chem 60: 1648-1661 (2017) Article DOI: 10.1021/acs.jmedchem.6b01594 BindingDB Entry DOI: 10.7270/Q2QZ2D7N | |||||||||||
More data for this Ligand-Target Pair |