Found 27 hits with Last Name = 'ruggeri' and Initial = 'p' Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Neuronal acetylcholine receptor subunit alpha-7
(Rattus norvegicus (Rat)) | BDBM50114008
(CHEMBL3603931)Show InChI InChI=1S/C11H15NO2/c1-12-6-5-9(12)8-14-11-4-2-3-10(13)7-11/h2-4,7,9,13H,5-6,8H2,1H3/t9-/m0/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 29 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ degli Studi di Milano
Curated by ChEMBL
| Assay Description Displacement of [125I]]-alpha-bungarotoxin from alpha7 nAChR in rat hippocampus membranes by liquid scintillation counting method |
J Med Chem 58: 6665-77 (2015)
Article DOI: 10.1021/acs.jmedchem.5b00904 BindingDB Entry DOI: 10.7270/Q2CF9RX4 |
More data for this Ligand-Target Pair | |
Neuronal acetylcholine receptor subunit alpha-7
(Rattus norvegicus (Rat)) | BDBM50113482
(CHEMBL3603941)Show InChI InChI=1S/C13H19NO2/c1-10(13-7-4-8-14(13)2)16-12-6-3-5-11(15)9-12/h3,5-6,9-10,13,15H,4,7-8H2,1-2H3/t10-,13+/m1/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 57 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ degli Studi di Milano
Curated by ChEMBL
| Assay Description Displacement of [125I]]-alpha-bungarotoxin from alpha7 nAChR in rat hippocampus membranes by liquid scintillation counting method |
J Med Chem 58: 6665-77 (2015)
Article DOI: 10.1021/acs.jmedchem.5b00904 BindingDB Entry DOI: 10.7270/Q2CF9RX4 |
More data for this Ligand-Target Pair | |
Neuronal acetylcholine receptor subunit alpha-7
(Rattus norvegicus (Rat)) | BDBM50114006
(CHEMBL3603929)Show InChI InChI=1S/C12H17NO2/c1-13-7-3-4-10(13)9-15-12-6-2-5-11(14)8-12/h2,5-6,8,10,14H,3-4,7,9H2,1H3/t10-/m0/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 119 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ degli Studi di Milano
Curated by ChEMBL
| Assay Description Displacement of [125I]]-alpha-bungarotoxin from alpha7 nAChR in rat hippocampus membranes by liquid scintillation counting method |
J Med Chem 58: 6665-77 (2015)
Article DOI: 10.1021/acs.jmedchem.5b00904 BindingDB Entry DOI: 10.7270/Q2CF9RX4 |
More data for this Ligand-Target Pair | |
Neuronal acetylcholine receptor subunit alpha-7
(Rattus norvegicus (Rat)) | BDBM50114005
(CHEMBL3603930)Show InChI InChI=1S/C11H15NO2/c13-10-4-1-5-11(7-10)14-8-9-3-2-6-12-9/h1,4-5,7,9,12-13H,2-3,6,8H2/t9-/m0/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 212 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ degli Studi di Milano
Curated by ChEMBL
| Assay Description Displacement of [125I]]-alpha-bungarotoxin from alpha7 nAChR in rat hippocampus membranes by liquid scintillation counting method |
J Med Chem 58: 6665-77 (2015)
Article DOI: 10.1021/acs.jmedchem.5b00904 BindingDB Entry DOI: 10.7270/Q2CF9RX4 |
More data for this Ligand-Target Pair | |
Neuronal acetylcholine receptor subunit alpha-7
(Rattus norvegicus (Rat)) | BDBM82070
(CAS_29790-52-1 | NICOTINE-L (BASE) | Nicotine-D sa...)Show InChI InChI=1S/C10H14N2/c1-12-7-3-5-10(12)9-4-2-6-11-8-9/h2,4,6,8,10H,3,5,7H2,1H3/t10-/m0/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| Purchase
KEGG PC cid PC sid PDB UniChem
Similars
| PDB Article PubMed
| 234 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ degli Studi di Milano
Curated by ChEMBL
| Assay Description Displacement of [125I]]-alpha-bungarotoxin from alpha7 nAChR in rat hippocampus membranes by liquid scintillation counting method |
J Med Chem 58: 6665-77 (2015)
Article DOI: 10.1021/acs.jmedchem.5b00904 BindingDB Entry DOI: 10.7270/Q2CF9RX4 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Neuronal acetylcholine receptor subunit alpha-7
(Rattus norvegicus (Rat)) | BDBM50114000
(CHEMBL3603933)Show InChI InChI=1S/C11H16N2O2/c1-13-4-2-3-9(13)8-15-11-5-10(14)6-12-7-11/h5-7,9,14H,2-4,8H2,1H3/t9-/m0/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| 321 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ degli Studi di Milano
Curated by ChEMBL
| Assay Description Displacement of [125I]]-alpha-bungarotoxin from alpha7 nAChR in rat hippocampus membranes by liquid scintillation counting method |
J Med Chem 58: 6665-77 (2015)
Article DOI: 10.1021/acs.jmedchem.5b00904 BindingDB Entry DOI: 10.7270/Q2CF9RX4 |
More data for this Ligand-Target Pair | |
Neuronal acetylcholine receptor subunit alpha-7
(Rattus norvegicus (Rat)) | BDBM50114004
(CHEMBL3603947)Show InChI InChI=1S/C12H18N2O/c1-10(12-6-4-8-14(12)2)15-11-5-3-7-13-9-11/h3,5,7,9-10,12H,4,6,8H2,1-2H3/t10-,12+/m1/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 388 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ degli Studi di Milano
Curated by ChEMBL
| Assay Description Displacement of [125I]]-alpha-bungarotoxin from alpha7 nAChR in rat hippocampus membranes by liquid scintillation counting method |
J Med Chem 58: 6665-77 (2015)
Article DOI: 10.1021/acs.jmedchem.5b00904 BindingDB Entry DOI: 10.7270/Q2CF9RX4 |
More data for this Ligand-Target Pair | |
Neuronal acetylcholine receptor subunit alpha-7
(Rattus norvegicus (Rat)) | BDBM50114019
(CHEMBL3603942)Show InChI InChI=1S/C13H19NO2/c1-10(13-7-4-8-14(13)2)16-12-6-3-5-11(15)9-12/h3,5-6,9-10,13,15H,4,7-8H2,1-2H3/t10-,13-/m0/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 743 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ degli Studi di Milano
Curated by ChEMBL
| Assay Description Displacement of [125I]]-alpha-bungarotoxin from alpha7 nAChR in rat hippocampus membranes by liquid scintillation counting method |
J Med Chem 58: 6665-77 (2015)
Article DOI: 10.1021/acs.jmedchem.5b00904 BindingDB Entry DOI: 10.7270/Q2CF9RX4 |
More data for this Ligand-Target Pair | |
Neuronal acetylcholine receptor subunit alpha-7
(Rattus norvegicus (Rat)) | BDBM50114015
(CHEMBL3603939)Show InChI InChI=1S/C13H19NO3/c1-14-7-3-4-10(14)9-17-13-8-11(15)5-6-12(13)16-2/h5-6,8,10,15H,3-4,7,9H2,1-2H3/t10-/m0/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 1.15E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ degli Studi di Milano
Curated by ChEMBL
| Assay Description Displacement of [125I]]-alpha-bungarotoxin from alpha7 nAChR in rat hippocampus membranes by liquid scintillation counting method |
J Med Chem 58: 6665-77 (2015)
Article DOI: 10.1021/acs.jmedchem.5b00904 BindingDB Entry DOI: 10.7270/Q2CF9RX4 |
More data for this Ligand-Target Pair | |
Neuronal acetylcholine receptor subunit alpha-7
(Rattus norvegicus (Rat)) | BDBM50114007
(CHEMBL3603932)Show InChI InChI=1S/C10H13NO2/c12-9-2-1-3-10(6-9)13-7-8-4-5-11-8/h1-3,6,8,11-12H,4-5,7H2/t8-/m0/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 1.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ degli Studi di Milano
Curated by ChEMBL
| Assay Description Displacement of [125I]]-alpha-bungarotoxin from alpha7 nAChR in rat hippocampus membranes by liquid scintillation counting method |
J Med Chem 58: 6665-77 (2015)
Article DOI: 10.1021/acs.jmedchem.5b00904 BindingDB Entry DOI: 10.7270/Q2CF9RX4 |
More data for this Ligand-Target Pair | |
Neuronal acetylcholine receptor subunit alpha-7
(Rattus norvegicus (Rat)) | BDBM50113999
(CHEMBL3603934)Show InChI InChI=1S/C10H14N2O2/c13-9-4-10(6-11-5-9)14-7-8-2-1-3-12-8/h4-6,8,12-13H,1-3,7H2/t8-/m0/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 3.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ degli Studi di Milano
Curated by ChEMBL
| Assay Description Displacement of [125I]]-alpha-bungarotoxin from alpha7 nAChR in rat hippocampus membranes by liquid scintillation counting method |
J Med Chem 58: 6665-77 (2015)
Article DOI: 10.1021/acs.jmedchem.5b00904 BindingDB Entry DOI: 10.7270/Q2CF9RX4 |
More data for this Ligand-Target Pair | |
Neuronal acetylcholine receptor subunit alpha-7
(Rattus norvegicus (Rat)) | BDBM50114003
(CHEMBL3603948)Show InChI InChI=1S/C12H18N2O/c1-10(12-6-4-8-14(12)2)15-11-5-3-7-13-9-11/h3,5,7,9-10,12H,4,6,8H2,1-2H3/t10-,12-/m0/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| 6.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ degli Studi di Milano
Curated by ChEMBL
| Assay Description Displacement of [125I]]-alpha-bungarotoxin from alpha7 nAChR in rat hippocampus membranes by liquid scintillation counting method |
J Med Chem 58: 6665-77 (2015)
Article DOI: 10.1021/acs.jmedchem.5b00904 BindingDB Entry DOI: 10.7270/Q2CF9RX4 |
More data for this Ligand-Target Pair | |
Neuronal acetylcholine receptor subunit alpha-7
(Rattus norvegicus (Rat)) | BDBM50114016
(CHEMBL3603938)Show InChI InChI=1S/C13H19NO/c1-11(13-9-6-10-14(13)2)15-12-7-4-3-5-8-12/h3-5,7-8,11,13H,6,9-10H2,1-2H3 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 8.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ degli Studi di Milano
Curated by ChEMBL
| Assay Description Displacement of [125I]]-alpha-bungarotoxin from alpha7 nAChR in rat hippocampus membranes by liquid scintillation counting method |
J Med Chem 58: 6665-77 (2015)
Article DOI: 10.1021/acs.jmedchem.5b00904 BindingDB Entry DOI: 10.7270/Q2CF9RX4 |
More data for this Ligand-Target Pair | |
Neuronal acetylcholine receptor subunit alpha-7
(Rattus norvegicus (Rat)) | BDBM50114011
(CHEMBL3603945)Show InChI InChI=1S/C12H18N2O2/c1-14-7-3-4-10(14)9-16-12-8-13-6-5-11(12)15-2/h5-6,8,10H,3-4,7,9H2,1-2H3/t10-/m0/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 9.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ degli Studi di Milano
Curated by ChEMBL
| Assay Description Displacement of [125I]]-alpha-bungarotoxin from alpha7 nAChR in rat hippocampus membranes by liquid scintillation counting method |
J Med Chem 58: 6665-77 (2015)
Article DOI: 10.1021/acs.jmedchem.5b00904 BindingDB Entry DOI: 10.7270/Q2CF9RX4 |
More data for this Ligand-Target Pair | |
Neuronal acetylcholine receptor subunit alpha-7
(Rattus norvegicus (Rat)) | BDBM50114014
(CHEMBL3603937)Show InChI InChI=1S/C13H19NO/c1-11(13-9-6-10-14(13)2)15-12-7-4-3-5-8-12/h3-5,7-8,11,13H,6,9-10H2,1-2H3/t11-,13+/m1/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 1.52E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ degli Studi di Milano
Curated by ChEMBL
| Assay Description Displacement of [125I]]-alpha-bungarotoxin from alpha7 nAChR in rat hippocampus membranes by liquid scintillation counting method |
J Med Chem 58: 6665-77 (2015)
Article DOI: 10.1021/acs.jmedchem.5b00904 BindingDB Entry DOI: 10.7270/Q2CF9RX4 |
More data for this Ligand-Target Pair | |
Neuronal acetylcholine receptor subunit alpha-7
(Rattus norvegicus (Rat)) | BDBM50114013
(CHEMBL3603946)Show InChI InChI=1S/C11H16N2O2/c1-14-10-4-6-12-7-11(10)15-8-9-3-2-5-13-9/h4,6-7,9,13H,2-3,5,8H2,1H3/t9-/m0/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 2.15E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ degli Studi di Milano
Curated by ChEMBL
| Assay Description Displacement of [125I]]-alpha-bungarotoxin from alpha7 nAChR in rat hippocampus membranes by liquid scintillation counting method |
J Med Chem 58: 6665-77 (2015)
Article DOI: 10.1021/acs.jmedchem.5b00904 BindingDB Entry DOI: 10.7270/Q2CF9RX4 |
More data for this Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50497171
(CHEMBL3286844)Show SMILES CSCC[C@H](NC(=O)c1ccc(NC(=O)Cc2csc(N)n2)cc1-c1ccoc1)C(O)=O |r| Show InChI InChI=1S/C21H22N4O5S2/c1-31-7-5-17(20(28)29)25-19(27)15-3-2-13(8-16(15)12-4-6-30-10-12)23-18(26)9-14-11-32-21(22)24-14/h2-4,6,8,10-11,17H,5,7,9H2,1H3,(H2,22,24)(H,23,26)(H,25,27)(H,28,29)/t17-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 2.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ di Milano
Curated by ChEMBL
| Assay Description Inhibition of recombinant FTase (unknown origin) by spectrofluorimetric analysis |
Bioorg Med Chem Lett 24: 2924-7 (2014)
Article DOI: 10.1016/j.bmcl.2014.04.078 BindingDB Entry DOI: 10.7270/Q2K35XM2 |
More data for this Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50497172
(CHEMBL3286836)Show SMILES CSCC[C@H](NC(=O)c1ccc(OCC2COc3ccccc3O2)cc1-c1ccsc1)C(O)=O |r| Show InChI InChI=1S/C25H25NO6S2/c1-33-10-9-21(25(28)29)26-24(27)19-7-6-17(12-20(19)16-8-11-34-15-16)30-13-18-14-31-22-4-2-3-5-23(22)32-18/h2-8,11-12,15,18,21H,9-10,13-14H2,1H3,(H,26,27)(H,28,29)/t18?,21-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 5.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ di Milano
Curated by ChEMBL
| Assay Description Inhibition of recombinant FTase (unknown origin) by spectrofluorimetric analysis |
Bioorg Med Chem Lett 24: 2924-7 (2014)
Article DOI: 10.1016/j.bmcl.2014.04.078 BindingDB Entry DOI: 10.7270/Q2K35XM2 |
More data for this Ligand-Target Pair | |
Neuronal acetylcholine receptor subunit alpha-4/beta-2
(Homo sapiens (Human)) | BDBM50114004
(CHEMBL3603947)Show InChI InChI=1S/C12H18N2O/c1-10(12-6-4-8-14(12)2)15-11-5-3-7-13-9-11/h3,5,7,9-10,12H,4,6,8H2,1-2H3/t10-,12+/m1/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | n/a | n/a | 13 | n/a | n/a | n/a | n/a |
Universit£ degli Studi di Milano
Curated by ChEMBL
| Assay Description Agonist activity at human alpha4beta2 nAChR expressed in rat GH4C1 cells assessed as induction of peak current amplitude at holding potential of -70 ... |
J Med Chem 58: 6665-77 (2015)
Article DOI: 10.1021/acs.jmedchem.5b00904 BindingDB Entry DOI: 10.7270/Q2CF9RX4 |
More data for this Ligand-Target Pair | |
Neuronal acetylcholine receptor subunit alpha-4/beta-2
(Homo sapiens (Human)) | BDBM10759
(2-acetoxyethyl(trimethyl)ammonium;bromide | 2-acet...)Show InChI InChI=1S/C7H16NO2/c1-7(9)10-6-5-8(2,3)4/h5-6H2,1-4H3/q+1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem
Similars
| Article PubMed
| n/a | n/a | n/a | n/a | 400 | n/a | n/a | n/a | n/a |
Universit£ degli Studi di Milano
Curated by ChEMBL
| Assay Description Agonist activity at human alpha4beta2 nAChR high affinity form expressed in rat GH4C1 cells assessed as induction of peak current amplitude at holdin... |
J Med Chem 58: 6665-77 (2015)
Article DOI: 10.1021/acs.jmedchem.5b00904 BindingDB Entry DOI: 10.7270/Q2CF9RX4 |
More data for this Ligand-Target Pair | |
Neuronal acetylcholine receptor subunit alpha-4/beta-2
(Homo sapiens (Human)) | BDBM50357064
(CHEMBL1917231)Show InChI InChI=1S/C13H17NO3/c1-14-6-2-3-10(14)13-8-16-11-5-4-9(15)7-12(11)17-13/h4-5,7,10,13,15H,2-3,6,8H2,1H3/t10-,13-/m0/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | n/a | n/a | 300 | n/a | n/a | n/a | n/a |
Universit£ degli Studi di Milano
Curated by ChEMBL
| Assay Description Agonist activity at human alpha4beta2 nAChR expressed in rat GH4C1 cells assessed as induction of peak current amplitude at holding potential of -70 ... |
J Med Chem 58: 6665-77 (2015)
Article DOI: 10.1021/acs.jmedchem.5b00904 BindingDB Entry DOI: 10.7270/Q2CF9RX4 |
More data for this Ligand-Target Pair | |
Neuronal acetylcholine receptor subunit alpha-4/beta-2
(Homo sapiens (Human)) | BDBM10759
(2-acetoxyethyl(trimethyl)ammonium;bromide | 2-acet...)Show InChI InChI=1S/C7H16NO2/c1-7(9)10-6-5-8(2,3)4/h5-6H2,1-4H3/q+1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem
Similars
| Article PubMed
| n/a | n/a | n/a | n/a | 1.00E+3 | n/a | n/a | n/a | n/a |
Universit£ degli Studi di Milano
Curated by ChEMBL
| Assay Description Agonist activity at human alpha4beta2 nAChR in (alpha4)2(beta2)3 stoichiometry form |
J Med Chem 58: 6665-77 (2015)
Article DOI: 10.1021/acs.jmedchem.5b00904 BindingDB Entry DOI: 10.7270/Q2CF9RX4 |
More data for this Ligand-Target Pair | |
Neuronal acetylcholine receptor subunit alpha-4/beta-2
(Homo sapiens (Human)) | BDBM50114000
(CHEMBL3603933)Show InChI InChI=1S/C11H16N2O2/c1-13-4-2-3-9(13)8-15-11-5-10(14)6-12-7-11/h5-7,9,14H,2-4,8H2,1H3/t9-/m0/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | n/a | n/a | 7.30E+4 | n/a | n/a | n/a | n/a |
Universit£ degli Studi di Milano
Curated by ChEMBL
| Assay Description Agonist activity at human alpha4beta2 nAChR expressed in rat GH4C1 cells assessed as induction of peak current amplitude at holding potential of -70 ... |
J Med Chem 58: 6665-77 (2015)
Article DOI: 10.1021/acs.jmedchem.5b00904 BindingDB Entry DOI: 10.7270/Q2CF9RX4 |
More data for this Ligand-Target Pair | |
Neuronal acetylcholine receptor subunit alpha-4/beta-2
(Homo sapiens (Human)) | BDBM50114006
(CHEMBL3603929)Show InChI InChI=1S/C12H17NO2/c1-13-7-3-4-10(13)9-15-12-6-2-5-11(14)8-12/h2,5-6,8,10,14H,3-4,7,9H2,1H3/t10-/m0/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | n/a | n/a | 4.40E+3 | n/a | n/a | n/a | n/a |
Universit£ degli Studi di Milano
Curated by ChEMBL
| Assay Description Agonist activity at human alpha4beta2 nAChR expressed in rat GH4C1 cells assessed as induction of peak current amplitude at holding potential of -70 ... |
J Med Chem 58: 6665-77 (2015)
Article DOI: 10.1021/acs.jmedchem.5b00904 BindingDB Entry DOI: 10.7270/Q2CF9RX4 |
More data for this Ligand-Target Pair | |
Neuronal acetylcholine receptor subunit alpha-4/beta-2
(Homo sapiens (Human)) | BDBM10759
(2-acetoxyethyl(trimethyl)ammonium;bromide | 2-acet...)Show InChI InChI=1S/C7H16NO2/c1-7(9)10-6-5-8(2,3)4/h5-6H2,1-4H3/q+1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem
Similars
| Article PubMed
| n/a | n/a | n/a | n/a | 1.00E+5 | n/a | n/a | n/a | n/a |
Universit£ degli Studi di Milano
Curated by ChEMBL
| Assay Description Agonist activity at human alpha4beta2 nAChR in (alpha4)3(beta2)2 stoichiometry form |
J Med Chem 58: 6665-77 (2015)
Article DOI: 10.1021/acs.jmedchem.5b00904 BindingDB Entry DOI: 10.7270/Q2CF9RX4 |
More data for this Ligand-Target Pair | |
Neuronal acetylcholine receptor subunit alpha-4/beta-2
(Homo sapiens (Human)) | BDBM10759
(2-acetoxyethyl(trimethyl)ammonium;bromide | 2-acet...)Show InChI InChI=1S/C7H16NO2/c1-7(9)10-6-5-8(2,3)4/h5-6H2,1-4H3/q+1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem
Similars
| Article PubMed
| n/a | n/a | n/a | n/a | 1.00E+5 | n/a | n/a | n/a | n/a |
Universit£ degli Studi di Milano
Curated by ChEMBL
| Assay Description Agonist activity at human alpha4beta2 nAChR low affinity form expressed in rat GH4C1 cells assessed as induction of peak current amplitude at holding... |
J Med Chem 58: 6665-77 (2015)
Article DOI: 10.1021/acs.jmedchem.5b00904 BindingDB Entry DOI: 10.7270/Q2CF9RX4 |
More data for this Ligand-Target Pair | |
Neuronal acetylcholine receptor subunit alpha-4/beta-2
(Homo sapiens (Human)) | BDBM50382474
(CHEMBL2024096 | US9303017, Sazetidine-A)Show InChI InChI=1S/C15H20N2O2/c18-8-4-2-1-3-5-13-9-15(11-16-10-13)19-12-14-6-7-17-14/h9-11,14,17-18H,1-2,4,6-8,12H2/t14-/m0/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | n/a | n/a | 0.270 | n/a | n/a | n/a | n/a |
Universit£ degli Studi di Milano
Curated by ChEMBL
| Assay Description Agonist activity at human alpha4beta2 nAChR expressed in rat GH4C1 cells assessed as induction of peak current amplitude at holding potential of -70 ... |
J Med Chem 58: 6665-77 (2015)
Article DOI: 10.1021/acs.jmedchem.5b00904 BindingDB Entry DOI: 10.7270/Q2CF9RX4 |
More data for this Ligand-Target Pair | |