Compile Data Set for Download or QSAR

Found 424 hits with Last Name = 'rybczynski' and Initial = 'p'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Lysosomal acid glucosylceramidase (Homo sapiens (Human))	BDBM108418 (US8604206, 13 | US8604206, 14) Show SMILES CC(F)[C@H]1CNC[C@@H](O)[C@@H]1O Show InChI InChI=1S/C7H14FNO2/c1-4(8)5-2-9-3-6(10)7(5)11/h4-7,9-11H,2-3H2,1H3/t4?,5-,6-,7-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	0.900	n/a	17.1	n/a	n/a	n/a	n/a	7.0	n/a
Amicus Therapeutics, Inc. US Patent					Assay Description The enzyme inhibition assays used monitored the ability of a test compound to bind and prevent the hydrolysis of a fluorogenic substrate in a concent...				US Patent US8604206 (2013) BindingDB Entry DOI: 10.7270/Q2MS3RDR
					More data for this Ligand-Target Pair
Lysosomal acid glucosylceramidase (Homo sapiens (Human))	BDBM108417 (US8604206, 6) Show SMILES O[C@@H]1CNC[C@H](C(F)F)[C@H]1O Show InChI InChI=1S/C6H11F2NO2/c7-6(8)3-1-9-2-4(10)5(3)11/h3-6,9-11H,1-2H2/t3-,4+,5+/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	3.06	n/a	5.80	n/a	n/a	n/a	n/a	7.0	n/a
Amicus Therapeutics, Inc. US Patent					Assay Description The enzyme inhibition assays used monitored the ability of a test compound to bind and prevent the hydrolysis of a fluorogenic substrate in a concent...				US Patent US8604206 (2013) BindingDB Entry DOI: 10.7270/Q2MS3RDR
					More data for this Ligand-Target Pair
Lysosomal acid glucosylceramidase (Homo sapiens (Human))	BDBM108418 (US8604206, 13 | US8604206, 14) Show SMILES CC(F)[C@H]1CNC[C@@H](O)[C@@H]1O Show InChI InChI=1S/C7H14FNO2/c1-4(8)5-2-9-3-6(10)7(5)11/h4-7,9-11H,2-3H2,1H3/t4?,5-,6-,7-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	4	n/a	7	n/a	n/a	n/a	n/a	7.0	n/a
Amicus Therapeutics, Inc. US Patent					Assay Description The enzyme inhibition assays used monitored the ability of a test compound to bind and prevent the hydrolysis of a fluorogenic substrate in a concent...				US Patent US8604206 (2013) BindingDB Entry DOI: 10.7270/Q2MS3RDR
					More data for this Ligand-Target Pair
Sodium/glucose cotransporter 2 (Homo sapiens (Human))	BDBM20877 (3-(1-benzofuran-5-yl)-1-(2-hydroxy-4-methyl-6-{[(2...) Show SMILES Cc1cc(O)c(C(=O)CCc2ccc3occc3c2)c(O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)c1 Show InChI InChI=1S/C24H26O9/c1-12-8-16(27)20(15(26)4-2-13-3-5-17-14(10-13)6-7-31-17)18(9-12)32-24-23(30)22(29)21(28)19(11-25)33-24/h3,5-10,19,21-25,27-30H,2,4,11H2,1H3/t19-,21-,22+,23-,24-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Johnson & Johnson Pharmaceutical Research and Development Curated by ChEMBL					Assay Description In vitro inhibition of Na-dependent [14C]-AMG uptake in CHO-K1 cells expressing human sodium glucose co-transporter 2				Bioorg Med Chem Lett 14: 5121-5 (2004) Article DOI: 10.1016/j.bmcl.2004.07.082 BindingDB Entry DOI: 10.7270/Q2VD6XX2
					More data for this Ligand-Target Pair
Lysosomal acid glucosylceramidase (Homo sapiens (Human))	BDBM108423 (US8604206, (3R,4R,5R)-5((S)-hydroxy(phenyl)methyl)...) Show SMILES O[C@@H]([C@H]1CNC[C@@H](O)[C@@H]1O)c1ccccc1 Show InChI InChI=1S/C12H17NO3/c14-10-7-13-6-9(12(10)16)11(15)8-4-2-1-3-5-8/h1-5,9-16H,6-7H2/t9-,10-,11-,12-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	8.90	n/a	17	n/a	n/a	n/a	n/a	7.0	n/a
Amicus Therapeutics, Inc. US Patent					Assay Description The enzyme inhibition assays used monitored the ability of a test compound to bind and prevent the hydrolysis of a fluorogenic substrate in a concent...				US Patent US8604206 (2013) BindingDB Entry DOI: 10.7270/Q2MS3RDR
					More data for this Ligand-Target Pair
Sodium/glucose cotransporter 2 (Homo sapiens (Human))	BDBM50153302 (3-(2,3-Dihydro-benzo[1,4]dioxin-6-yl)-1-[2-hydroxy...) Show SMILES Cc1cc(O)c(C(=O)CCc2ccc3OCCOc3c2)c(O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)c1 Show InChI InChI=1S/C24H28O10/c1-12-8-15(27)20(14(26)4-2-13-3-5-16-17(10-13)32-7-6-31-16)18(9-12)33-24-23(30)22(29)21(28)19(11-25)34-24/h3,5,8-10,19,21-25,27-30H,2,4,6-7,11H2,1H3/t19-,21-,22+,23-,24-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL KEGG PC cid PC sid UniChem Similars	Article PubMed	9	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Johnson & Johnson Pharmaceutical Research and Development Curated by ChEMBL					Assay Description In vitro inhibition of Na-dependent [14C]-AMG uptake in CHO-K1 cells expressing human sodium glucose co-transporter 2				Bioorg Med Chem Lett 14: 5121-5 (2004) Article DOI: 10.1016/j.bmcl.2004.07.082 BindingDB Entry DOI: 10.7270/Q2VD6XX2
					More data for this Ligand-Target Pair
Lysosomal acid glucosylceramidase (Homo sapiens (Human))	BDBM108419 (US8604206, 10 | US8604206, 9) Show SMILES CC(O)[C@H]1CNC[C@@H](O)[C@@H]1O Show InChI InChI=1S/C7H15NO3/c1-4(9)5-2-8-3-6(10)7(5)11/h4-11H,2-3H2,1H3/t4?,5-,6-,7-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	10	n/a	20	n/a	n/a	n/a	n/a	7.0	n/a
Amicus Therapeutics, Inc. US Patent					Assay Description The enzyme inhibition assays used monitored the ability of a test compound to bind and prevent the hydrolysis of a fluorogenic substrate in a concent...				US Patent US8604206 (2013) BindingDB Entry DOI: 10.7270/Q2MS3RDR
					More data for this Ligand-Target Pair
Sodium/glucose cotransporter 2 (Homo sapiens (Human))	BDBM50153298 (3-(2,3-Dihydro-benzo[1,4]dioxin-6-yl)-1-[4-ethyl-2...) Show SMILES CCc1cc(O)c(C(=O)CCc2ccc3OCCOc3c2)c(O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)c1 Show InChI InChI=1S/C25H30O10/c1-2-13-9-16(28)21(15(27)5-3-14-4-6-17-18(11-14)33-8-7-32-17)19(10-13)34-25-24(31)23(30)22(29)20(12-26)35-25/h4,6,9-11,20,22-26,28-31H,2-3,5,7-8,12H2,1H3/t20-,22-,23+,24-,25-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid UniChem Similars	Article PubMed	10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Johnson & Johnson Pharmaceutical Research and Development Curated by ChEMBL					Assay Description In vitro inhibition of Na-dependent [14C]-AMG uptake in CHO-K1 cells expressing human sodium glucose co-transporter 2				Bioorg Med Chem Lett 14: 5121-5 (2004) Article DOI: 10.1016/j.bmcl.2004.07.082 BindingDB Entry DOI: 10.7270/Q2VD6XX2
					More data for this Ligand-Target Pair
Sodium/glucose cotransporter 2 (Homo sapiens (Human))	BDBM50153301 (3-(4-Ethoxy-phenyl)-1-[2-hydroxy-4-methyl-6-(3,4,5...) Show SMILES CCOc1ccc(CCC(=O)c2c(O)cc(C)cc2O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)cc1 Show InChI InChI=1S/C24H30O9/c1-3-31-15-7-4-14(5-8-15)6-9-16(26)20-17(27)10-13(2)11-18(20)32-24-23(30)22(29)21(28)19(12-25)33-24/h4-5,7-8,10-11,19,21-25,27-30H,3,6,9,12H2,1-2H3/t19-,21-,22+,23-,24-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL KEGG PC cid PC sid UniChem Similars	Article PubMed	10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Johnson & Johnson Pharmaceutical Research and Development Curated by ChEMBL					Assay Description In vitro inhibition of Na-dependent [14C]-AMG uptake in CHO-K1 cells expressing human sodium glucose co-transporter 2				Bioorg Med Chem Lett 14: 5121-5 (2004) Article DOI: 10.1016/j.bmcl.2004.07.082 BindingDB Entry DOI: 10.7270/Q2VD6XX2
					More data for this Ligand-Target Pair
Sodium/glucose cotransporter 2 (Homo sapiens (Human))	BDBM50153312 (1-[2-Hydroxy-4-methyl-6-(3,4,5-trihydroxy-6-hydrox...) Show SMILES Cc1cc(O)c(C(=O)CCc2ccc3ccccc3c2)c(O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)c1 Show InChI InChI=1S/C26H28O8/c1-14-10-19(29)22(18(28)9-7-15-6-8-16-4-2-3-5-17(16)12-15)20(11-14)33-26-25(32)24(31)23(30)21(13-27)34-26/h2-6,8,10-12,21,23-27,29-32H,7,9,13H2,1H3/t21-,23-,24+,25-,26-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL KEGG PC cid PC sid UniChem Similars	Article PubMed	10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Johnson & Johnson Pharmaceutical Research and Development Curated by ChEMBL					Assay Description In vitro inhibition of Na-dependent [14C]-AMG uptake in CHO-K1 cells expressing human sodium glucose co-transporter 2				Bioorg Med Chem Lett 14: 5121-5 (2004) Article DOI: 10.1016/j.bmcl.2004.07.082 BindingDB Entry DOI: 10.7270/Q2VD6XX2
					More data for this Ligand-Target Pair
Sodium/glucose cotransporter 2 (Homo sapiens (Human))	BDBM50153305 (1-[4-Ethyl-2-hydroxy-6-(3,4,5-trihydroxy-6-hydroxy...) Show SMILES CCc1cc(O)c(C(=O)CCc2ccc3ccccc3c2)c(O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)c1 Show InChI InChI=1S/C27H30O8/c1-2-15-12-20(30)23(19(29)10-8-16-7-9-17-5-3-4-6-18(17)11-16)21(13-15)34-27-26(33)25(32)24(31)22(14-28)35-27/h3-7,9,11-13,22,24-28,30-33H,2,8,10,14H2,1H3/t22-,24-,25+,26-,27-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL KEGG PC cid PC sid UniChem Similars	Article PubMed	10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Johnson & Johnson Pharmaceutical Research and Development Curated by ChEMBL					Assay Description In vitro inhibition of Na-dependent [14C]-AMG uptake in CHO-K1 cells expressing human sodium glucose co-transporter 2				Bioorg Med Chem Lett 14: 5121-5 (2004) Article DOI: 10.1016/j.bmcl.2004.07.082 BindingDB Entry DOI: 10.7270/Q2VD6XX2
					More data for this Ligand-Target Pair
Lysosomal acid glucosylceramidase (Homo sapiens (Human))	BDBM108417 (US8604206, 6) Show SMILES O[C@@H]1CNC[C@H](C(F)F)[C@H]1O Show InChI InChI=1S/C6H11F2NO2/c7-6(8)3-1-9-2-4(10)5(3)11/h3-6,9-11H,1-2H2/t3-,4+,5+/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	13.6	n/a	25.9	n/a	n/a	n/a	n/a	5.2	n/a
Amicus Therapeutics, Inc. US Patent					Assay Description The enzyme inhibition assays used monitored the ability of a test compound to bind and prevent the hydrolysis of a fluorogenic substrate in a concent...				US Patent US8604206 (2013) BindingDB Entry DOI: 10.7270/Q2MS3RDR
					More data for this Ligand-Target Pair
Lysosomal acid glucosylceramidase (Homo sapiens (Human))	BDBM108424 (US8604206, (3R,4R,5S)-5(2-hydroxypropan-2-yl)piper...) Show SMILES CC(C)(O)[C@H]1CNC[C@@H](O)[C@@H]1O Show InChI InChI=1S/C8H17NO3/c1-8(2,12)5-3-9-4-6(10)7(5)11/h5-7,9-12H,3-4H2,1-2H3/t5-,6+,7+/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	15	n/a	29	n/a	n/a	n/a	n/a	7.0	n/a
Amicus Therapeutics, Inc. US Patent					Assay Description The enzyme inhibition assays used monitored the ability of a test compound to bind and prevent the hydrolysis of a fluorogenic substrate in a concent...				US Patent US8604206 (2013) BindingDB Entry DOI: 10.7270/Q2MS3RDR
					More data for this Ligand-Target Pair
Lysosomal acid glucosylceramidase (Homo sapiens (Human))	BDBM108418 (US8604206, 13 | US8604206, 14) Show SMILES CC(F)[C@H]1CNC[C@@H](O)[C@@H]1O Show InChI InChI=1S/C7H14FNO2/c1-4(8)5-2-9-3-6(10)7(5)11/h4-7,9-11H,2-3H2,1H3/t4?,5-,6-,7-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	16	n/a	38	n/a	n/a	n/a	n/a	5.2	n/a
Amicus Therapeutics, Inc. US Patent					Assay Description The enzyme inhibition assays used monitored the ability of a test compound to bind and prevent the hydrolysis of a fluorogenic substrate in a concent...				US Patent US8604206 (2013) BindingDB Entry DOI: 10.7270/Q2MS3RDR
					More data for this Ligand-Target Pair
Sodium/glucose cotransporter 2 (Homo sapiens (Human))	BDBM50153293 (1-[4-Chloro-2-hydroxy-6-(3,4,5-trihydroxy-6-hydrox...) Show SMILES OC[C@H]1O[C@@H](Oc2cc(Cl)cc(O)c2C(=O)CCc2ccc3OCCOc3c2)[C@H](O)[C@@H](O)[C@@H]1O Show InChI InChI=1S/C23H25ClO10/c24-12-8-14(27)19(13(26)3-1-11-2-4-15-16(7-11)32-6-5-31-15)17(9-12)33-23-22(30)21(29)20(28)18(10-25)34-23/h2,4,7-9,18,20-23,25,27-30H,1,3,5-6,10H2/t18-,20-,21+,22-,23-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL KEGG PC cid PC sid UniChem Similars	Article PubMed	20	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Johnson & Johnson Pharmaceutical Research and Development Curated by ChEMBL					Assay Description In vitro inhibition of Na-dependent [14C]-AMG uptake in CHO-K1 cells expressing human sodium glucose co-transporter 2				Bioorg Med Chem Lett 14: 5121-5 (2004) Article DOI: 10.1016/j.bmcl.2004.07.082 BindingDB Entry DOI: 10.7270/Q2VD6XX2
					More data for this Ligand-Target Pair
Sodium/glucose cotransporter 2 (Homo sapiens (Human))	BDBM50153309 (3-(2,3-Dihydro-benzo[1,4]dioxin-6-yl)-1-[2-hydroxy...) Show SMILES CC(C)c1cc(O)c(C(=O)CCc2ccc3OCCOc3c2)c(O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)c1 Show InChI InChI=1S/C26H32O10/c1-13(2)15-10-17(29)22(16(28)5-3-14-4-6-18-19(9-14)34-8-7-33-18)20(11-15)35-26-25(32)24(31)23(30)21(12-27)36-26/h4,6,9-11,13,21,23-27,29-32H,3,5,7-8,12H2,1-2H3/t21-,23-,24+,25-,26-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL KEGG PC cid PC sid UniChem Similars	Article PubMed	20	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Johnson & Johnson Pharmaceutical Research and Development Curated by ChEMBL					Assay Description In vitro inhibition of Na-dependent [14C]-AMG uptake in CHO-K1 cells expressing human sodium glucose co-transporter 2				Bioorg Med Chem Lett 14: 5121-5 (2004) Article DOI: 10.1016/j.bmcl.2004.07.082 BindingDB Entry DOI: 10.7270/Q2VD6XX2
					More data for this Ligand-Target Pair
Sodium/glucose cotransporter 2 (Homo sapiens (Human))	BDBM50153296 (1-[4-Chloro-2-hydroxy-6-(3,4,5-trihydroxy-6-hydrox...) Show SMILES OC[C@H]1O[C@@H](Oc2cc(Cl)cc(O)c2C(=O)CCc2ccc3ccccc3c2)[C@H](O)[C@@H](O)[C@@H]1O Show InChI InChI=1S/C25H25ClO8/c26-16-10-18(29)21(17(28)8-6-13-5-7-14-3-1-2-4-15(14)9-13)19(11-16)33-25-24(32)23(31)22(30)20(12-27)34-25/h1-5,7,9-11,20,22-25,27,29-32H,6,8,12H2/t20-,22-,23+,24-,25-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL KEGG PC cid PC sid UniChem Similars	Article PubMed	30	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Johnson & Johnson Pharmaceutical Research and Development Curated by ChEMBL					Assay Description In vitro inhibition of Na-dependent [14C]-AMG uptake in CHO-K1 cells expressing human sodium glucose co-transporter 2				Bioorg Med Chem Lett 14: 5121-5 (2004) Article DOI: 10.1016/j.bmcl.2004.07.082 BindingDB Entry DOI: 10.7270/Q2VD6XX2
					More data for this Ligand-Target Pair
Sodium/glucose cotransporter 2 (Homo sapiens (Human))	BDBM50153294 (3-(4-Ethoxy-phenyl)-1-[4-ethyl-2-hydroxy-6-(3,4,5-...) Show SMILES CCOc1ccc(CCC(=O)c2c(O)cc(CC)cc2O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)cc1 Show InChI InChI=1S/C25H32O9/c1-3-14-11-18(28)21(17(27)10-7-15-5-8-16(9-6-15)32-4-2)19(12-14)33-25-24(31)23(30)22(29)20(13-26)34-25/h5-6,8-9,11-12,20,22-26,28-31H,3-4,7,10,13H2,1-2H3/t20-,22-,23+,24-,25-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL KEGG PC cid PC sid UniChem Similars	Article PubMed	30	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Johnson & Johnson Pharmaceutical Research and Development Curated by ChEMBL					Assay Description In vitro inhibition of Na-dependent [14C]-AMG uptake in CHO-K1 cells expressing human sodium glucose co-transporter 2				Bioorg Med Chem Lett 14: 5121-5 (2004) Article DOI: 10.1016/j.bmcl.2004.07.082 BindingDB Entry DOI: 10.7270/Q2VD6XX2
					More data for this Ligand-Target Pair
Lysosomal acid glucosylceramidase (Homo sapiens (Human))	BDBM47182 (US8604206, (3R,4R,5S)-5-((R)-1-fluoropropyl)-piper...) Show SMILES CC[C@@H](F)C1CNC[C@@H](O)[C@@H]1O Show InChI InChI=1S/C8H16FNO2/c1-2-6(9)5-3-10-4-7(11)8(5)12/h5-8,10-12H,2-4H2,1H3/t5?,6-,7-,8-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	31	n/a	60	n/a	n/a	n/a	n/a	n/a	n/a
Amicus Therapeutics, Inc. US Patent					Assay Description The enzyme inhibition assays used monitored the ability of a test compound to bind and prevent the hydrolysis of a fluorogenic substrate in a concent...				US Patent US8604206 (2013) BindingDB Entry DOI: 10.7270/Q2MS3RDR
					More data for this Ligand-Target Pair
Lysosomal acid glucosylceramidase (Homo sapiens (Human))	BDBM108419 (US8604206, 10 | US8604206, 9) Show SMILES CC(O)[C@H]1CNC[C@@H](O)[C@@H]1O Show InChI InChI=1S/C7H15NO3/c1-4(9)5-2-8-3-6(10)7(5)11/h4-11H,2-3H2,1H3/t4?,5-,6-,7-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	35	n/a	66	n/a	n/a	n/a	n/a	7.0	n/a
Amicus Therapeutics, Inc. US Patent					Assay Description The enzyme inhibition assays used monitored the ability of a test compound to bind and prevent the hydrolysis of a fluorogenic substrate in a concent...				US Patent US8604206 (2013) BindingDB Entry DOI: 10.7270/Q2MS3RDR
					More data for this Ligand-Target Pair
Sodium/glucose cotransporter 2 (Homo sapiens (Human))	BDBM50153313 (3-Cyclohexyl-1-[2-hydroxy-4-methyl-6-(3,4,5-trihyd...) Show SMILES Cc1cc(O)c(C(=O)CCC2CCCCC2)c(O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)c1 Show InChI InChI=1S/C22H32O8/c1-12-9-15(25)18(14(24)8-7-13-5-3-2-4-6-13)16(10-12)29-22-21(28)20(27)19(26)17(11-23)30-22/h9-10,13,17,19-23,25-28H,2-8,11H2,1H3/t17-,19-,20+,21-,22-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL KEGG PC cid PC sid UniChem Similars	Article PubMed	40	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Johnson & Johnson Pharmaceutical Research and Development Curated by ChEMBL					Assay Description In vitro inhibition of Na-dependent [14C]-AMG uptake in CHO-K1 cells expressing human sodium glucose co-transporter 2				Bioorg Med Chem Lett 14: 5121-5 (2004) Article DOI: 10.1016/j.bmcl.2004.07.082 BindingDB Entry DOI: 10.7270/Q2VD6XX2
					More data for this Ligand-Target Pair
Lysosomal acid glucosylceramidase (Homo sapiens (Human))	BDBM108419 (US8604206, 10 | US8604206, 9) Show SMILES CC(O)[C@H]1CNC[C@@H](O)[C@@H]1O Show InChI InChI=1S/C7H15NO3/c1-4(9)5-2-8-3-6(10)7(5)11/h4-11H,2-3H2,1H3/t4?,5-,6-,7-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	44	n/a	107	n/a	n/a	n/a	n/a	5.2	n/a
Amicus Therapeutics, Inc. US Patent					Assay Description The enzyme inhibition assays used monitored the ability of a test compound to bind and prevent the hydrolysis of a fluorogenic substrate in a concent...				US Patent US8604206 (2013) BindingDB Entry DOI: 10.7270/Q2MS3RDR
					More data for this Ligand-Target Pair
Lysosomal acid glucosylceramidase (Homo sapiens (Human))	BDBM108418 (US8604206, 13 | US8604206, 14) Show SMILES CC(F)[C@H]1CNC[C@@H](O)[C@@H]1O Show InChI InChI=1S/C7H14FNO2/c1-4(8)5-2-9-3-6(10)7(5)11/h4-7,9-11H,2-3H2,1H3/t4?,5-,6-,7-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	49.8	n/a	94.6	n/a	n/a	n/a	n/a	5.2	n/a
Amicus Therapeutics, Inc. US Patent					Assay Description The enzyme inhibition assays used monitored the ability of a test compound to bind and prevent the hydrolysis of a fluorogenic substrate in a concent...				US Patent US8604206 (2013) BindingDB Entry DOI: 10.7270/Q2MS3RDR
					More data for this Ligand-Target Pair
Sodium/glucose cotransporter 1 (Homo sapiens (Human))	BDBM20877 (3-(1-benzofuran-5-yl)-1-(2-hydroxy-4-methyl-6-{[(2...) Show SMILES Cc1cc(O)c(C(=O)CCc2ccc3occc3c2)c(O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)c1 Show InChI InChI=1S/C24H26O9/c1-12-8-16(27)20(15(26)4-2-13-3-5-17-14(10-13)6-7-31-17)18(9-12)32-24-23(30)22(29)21(28)19(11-25)33-24/h3,5-10,19,21-25,27-30H,2,4,11H2,1H3/t19-,21-,22+,23-,24-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	50	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Johnson & Johnson Pharmaceutical Research and Development Curated by ChEMBL					Assay Description In vitro inhibition of Na-dependent [14C]-AMG uptake in CHO-K1 cells expressing human sodium glucose co-transporter 1				Bioorg Med Chem Lett 14: 5121-5 (2004) Article DOI: 10.1016/j.bmcl.2004.07.082 BindingDB Entry DOI: 10.7270/Q2VD6XX2
					More data for this Ligand-Target Pair
Lysosomal acid glucosylceramidase (Homo sapiens (Human))	BDBM108422 (US8604206, (3R,4R,5S)-5-benzyl-piperidine-3,4-diol) Show SMILES O[C@@H]1CNC[C@H](Cc2ccccc2)[C@H]1O Show InChI InChI=1S/C12H17NO2/c14-11-8-13-7-10(12(11)15)6-9-4-2-1-3-5-9/h1-5,10-15H,6-8H2/t10-,11+,12+/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	67	n/a	127	n/a	n/a	n/a	n/a	7.0	n/a
Amicus Therapeutics, Inc. US Patent					Assay Description The enzyme inhibition assays used monitored the ability of a test compound to bind and prevent the hydrolysis of a fluorogenic substrate in a concent...				US Patent US8604206 (2013) BindingDB Entry DOI: 10.7270/Q2MS3RDR
					More data for this Ligand-Target Pair
Sodium/glucose cotransporter 2 (Homo sapiens (Human))	BDBM50153292 (1-[4-Fluoro-2-hydroxy-6-(3,4,5-trihydroxy-6-hydrox...) Show SMILES OC[C@H]1O[C@@H](Oc2cc(F)cc(O)c2C(=O)CCc2ccc3ccccc3c2)[C@H](O)[C@@H](O)[C@@H]1O Show InChI InChI=1S/C25H25FO8/c26-16-10-18(29)21(17(28)8-6-13-5-7-14-3-1-2-4-15(14)9-13)19(11-16)33-25-24(32)23(31)22(30)20(12-27)34-25/h1-5,7,9-11,20,22-25,27,29-32H,6,8,12H2/t20-,22-,23+,24-,25-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL KEGG PC cid PC sid UniChem Similars	Article PubMed	70	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Johnson & Johnson Pharmaceutical Research and Development Curated by ChEMBL					Assay Description In vitro inhibition of Na-dependent [14C]-AMG uptake in CHO-K1 cells expressing human sodium glucose co-transporter 2				Bioorg Med Chem Lett 14: 5121-5 (2004) Article DOI: 10.1016/j.bmcl.2004.07.082 BindingDB Entry DOI: 10.7270/Q2VD6XX2
					More data for this Ligand-Target Pair
Sodium/glucose cotransporter 2 (Homo sapiens (Human))	BDBM50153306 (1-[2-Hydroxy-4-methyl-6-(3,4,5-trihydroxy-6-hydrox...) Show SMILES Cc1cc(O)c(C(=O)CCc2ccsc2)c(O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)c1 Show InChI InChI=1S/C20H24O8S/c1-10-6-13(23)16(12(22)3-2-11-4-5-29-9-11)14(7-10)27-20-19(26)18(25)17(24)15(8-21)28-20/h4-7,9,15,17-21,23-26H,2-3,8H2,1H3/t15-,17-,18+,19-,20-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL KEGG PC cid PC sid UniChem Similars	Article PubMed	70	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Johnson & Johnson Pharmaceutical Research and Development Curated by ChEMBL					Assay Description In vitro inhibition of Na-dependent [14C]-AMG uptake in CHO-K1 cells expressing human sodium glucose co-transporter 2				Bioorg Med Chem Lett 14: 5121-5 (2004) Article DOI: 10.1016/j.bmcl.2004.07.082 BindingDB Entry DOI: 10.7270/Q2VD6XX2
					More data for this Ligand-Target Pair
Sodium/glucose cotransporter 2 (Homo sapiens (Human))	BDBM50153299 (1-[4-Chloro-2-hydroxy-6-(3,4,5-trihydroxy-6-hydrox...) Show SMILES CCOc1ccc(CCC(=O)c2c(O)cc(Cl)cc2O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)cc1 Show InChI InChI=1S/C23H27ClO9/c1-2-31-14-6-3-12(4-7-14)5-8-15(26)19-16(27)9-13(24)10-17(19)32-23-22(30)21(29)20(28)18(11-25)33-23/h3-4,6-7,9-10,18,20-23,25,27-30H,2,5,8,11H2,1H3/t18-,20-,21+,22-,23-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL KEGG PC cid PC sid UniChem Similars	Article PubMed	80	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Johnson & Johnson Pharmaceutical Research and Development Curated by ChEMBL					Assay Description In vitro inhibition of Na-dependent [14C]-AMG uptake in CHO-K1 cells expressing human sodium glucose co-transporter 2				Bioorg Med Chem Lett 14: 5121-5 (2004) Article DOI: 10.1016/j.bmcl.2004.07.082 BindingDB Entry DOI: 10.7270/Q2VD6XX2
					More data for this Ligand-Target Pair
Lysosomal acid glucosylceramidase (Homo sapiens (Human))	BDBM108424 (US8604206, (3R,4R,5S)-5(2-hydroxypropan-2-yl)piper...) Show SMILES CC(C)(O)[C@H]1CNC[C@@H](O)[C@@H]1O Show InChI InChI=1S/C8H17NO3/c1-8(2,12)5-3-9-4-6(10)7(5)11/h5-7,9-12H,3-4H2,1-2H3/t5-,6+,7+/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	97	n/a	234	n/a	n/a	n/a	n/a	5.2	n/a
Amicus Therapeutics, Inc. US Patent					Assay Description The enzyme inhibition assays used monitored the ability of a test compound to bind and prevent the hydrolysis of a fluorogenic substrate in a concent...				US Patent US8604206 (2013) BindingDB Entry DOI: 10.7270/Q2MS3RDR
					More data for this Ligand-Target Pair
Sodium/glucose cotransporter 2 (Homo sapiens (Human))	BDBM50153304 (3-(4-Ethoxy-phenyl)-1-[2-hydroxy-4-isopropyl-6-(3,...) Show SMILES CCOc1ccc(CCC(=O)c2c(O)cc(cc2O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)C(C)C)cc1 Show InChI InChI=1S/C26H34O9/c1-4-33-17-8-5-15(6-9-17)7-10-18(28)22-19(29)11-16(14(2)3)12-20(22)34-26-25(32)24(31)23(30)21(13-27)35-26/h5-6,8-9,11-12,14,21,23-27,29-32H,4,7,10,13H2,1-3H3/t21-,23-,24+,25-,26-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL KEGG PC cid PC sid UniChem Similars	Article PubMed	110	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Johnson & Johnson Pharmaceutical Research and Development Curated by ChEMBL					Assay Description In vitro inhibition of Na-dependent [14C]-AMG uptake in CHO-K1 cells expressing human sodium glucose co-transporter 2				Bioorg Med Chem Lett 14: 5121-5 (2004) Article DOI: 10.1016/j.bmcl.2004.07.082 BindingDB Entry DOI: 10.7270/Q2VD6XX2
					More data for this Ligand-Target Pair
Lysosomal acid glucosylceramidase (Homo sapiens (Human))	BDBM47182 (US8604206, (3R,4R,5S)-5-((R)-1-fluoropropyl)-piper...) Show SMILES CC[C@@H](F)C1CNC[C@@H](O)[C@@H]1O Show InChI InChI=1S/C8H16FNO2/c1-2-6(9)5-3-10-4-7(11)8(5)12/h5-8,10-12H,2-4H2,1H3/t5?,6-,7-,8-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	121	n/a	291	n/a	n/a	n/a	n/a	n/a	n/a
Amicus Therapeutics, Inc. US Patent					Assay Description The enzyme inhibition assays used monitored the ability of a test compound to bind and prevent the hydrolysis of a fluorogenic substrate in a concent...				US Patent US8604206 (2013) BindingDB Entry DOI: 10.7270/Q2MS3RDR
					More data for this Ligand-Target Pair
Lysosomal acid glucosylceramidase (Homo sapiens (Human))	BDBM108419 (US8604206, 10 | US8604206, 9) Show SMILES CC(O)[C@H]1CNC[C@@H](O)[C@@H]1O Show InChI InChI=1S/C7H15NO3/c1-4(9)5-2-8-3-6(10)7(5)11/h4-11H,2-3H2,1H3/t4?,5-,6-,7-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	142	n/a	343	n/a	n/a	n/a	n/a	5.2	n/a
Amicus Therapeutics, Inc. US Patent					Assay Description The enzyme inhibition assays used monitored the ability of a test compound to bind and prevent the hydrolysis of a fluorogenic substrate in a concent...				US Patent US8604206 (2013) BindingDB Entry DOI: 10.7270/Q2MS3RDR
					More data for this Ligand-Target Pair
Sodium/glucose cotransporter 2 (Homo sapiens (Human))	BDBM50153307 (1-[2-Hydroxy-4-isopropyl-6-(3,4,5-trihydroxy-6-hyd...) Show SMILES CC(C)c1cc(O)c(C(=O)CCc2ccc3ccccc3c2)c(O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)c1 Show InChI InChI=1S/C28H32O8/c1-15(2)19-12-21(31)24(20(30)10-8-16-7-9-17-5-3-4-6-18(17)11-16)22(13-19)35-28-27(34)26(33)25(32)23(14-29)36-28/h3-7,9,11-13,15,23,25-29,31-34H,8,10,14H2,1-2H3/t23-,25-,26+,27-,28-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL KEGG PC cid PC sid UniChem Similars	Article PubMed	150	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Johnson & Johnson Pharmaceutical Research and Development Curated by ChEMBL					Assay Description In vitro inhibition of Na-dependent [14C]-AMG uptake in CHO-K1 cells expressing human sodium glucose co-transporter 2				Bioorg Med Chem Lett 14: 5121-5 (2004) Article DOI: 10.1016/j.bmcl.2004.07.082 BindingDB Entry DOI: 10.7270/Q2VD6XX2
					More data for this Ligand-Target Pair
Sodium/glucose cotransporter 2 (Homo sapiens (Human))	BDBM50153303 (3-Furan-3-yl-1-[2-hydroxy-4-methyl-6-(3,4,5-trihyd...) Show SMILES Cc1cc(O)c(C(=O)CCc2ccoc2)c(O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)c1 Show InChI InChI=1S/C20H24O9/c1-10-6-13(23)16(12(22)3-2-11-4-5-27-9-11)14(7-10)28-20-19(26)18(25)17(24)15(8-21)29-20/h4-7,9,15,17-21,23-26H,2-3,8H2,1H3/t15-,17-,18+,19-,20-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL KEGG PC cid PC sid UniChem Similars	Article PubMed	230	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Johnson & Johnson Pharmaceutical Research and Development Curated by ChEMBL					Assay Description In vitro inhibition of Na-dependent [14C]-AMG uptake in CHO-K1 cells expressing human sodium glucose co-transporter 2				Bioorg Med Chem Lett 14: 5121-5 (2004) Article DOI: 10.1016/j.bmcl.2004.07.082 BindingDB Entry DOI: 10.7270/Q2VD6XX2
					More data for this Ligand-Target Pair
Lysosomal acid glucosylceramidase (Homo sapiens (Human))	BDBM108422 (US8604206, (3R,4R,5S)-5-benzyl-piperidine-3,4-diol) Show SMILES O[C@@H]1CNC[C@H](Cc2ccccc2)[C@H]1O Show InChI InChI=1S/C12H17NO2/c14-11-8-13-7-10(12(11)15)6-9-4-2-1-3-5-9/h1-5,10-15H,6-8H2/t10-,11+,12+/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	273	n/a	659	n/a	n/a	n/a	n/a	5.2	n/a
Amicus Therapeutics, Inc. US Patent					Assay Description The enzyme inhibition assays used monitored the ability of a test compound to bind and prevent the hydrolysis of a fluorogenic substrate in a concent...				US Patent US8604206 (2013) BindingDB Entry DOI: 10.7270/Q2MS3RDR
					More data for this Ligand-Target Pair
Sodium/glucose cotransporter 2 (Homo sapiens (Human))	BDBM50153311 (1-[2-Amino-4-methyl-6-(3,4,5-trihydroxy-6-hydroxym...) Show SMILES Cc1cc(N)c(C(=O)CCc2ccc3OCCOc3c2)c(O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)c1 Show InChI InChI=1S/C24H29NO9/c1-12-8-14(25)20(15(27)4-2-13-3-5-16-17(10-13)32-7-6-31-16)18(9-12)33-24-23(30)22(29)21(28)19(11-26)34-24/h3,5,8-10,19,21-24,26,28-30H,2,4,6-7,11,25H2,1H3/t19-,21-,22+,23-,24-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL KEGG PC cid PC sid UniChem Similars	Article PubMed	290	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Johnson & Johnson Pharmaceutical Research and Development Curated by ChEMBL					Assay Description In vitro inhibition of Na-dependent [14C]-AMG uptake in CHO-K1 cells expressing human sodium glucose co-transporter 2				Bioorg Med Chem Lett 14: 5121-5 (2004) Article DOI: 10.1016/j.bmcl.2004.07.082 BindingDB Entry DOI: 10.7270/Q2VD6XX2
					More data for this Ligand-Target Pair
Beta-galactosidase (Homo sapiens (Human))	BDBM50358321 (CHEMBL1922579 | CHEMBL1922581) Show SMILES CCCCCCCCN[C@@H]1C=C(CO)[C@H](O)[C@H](O)[C@H]1O |r,t:10| Show InChI InChI=1S/C15H29NO4/c1-2-3-4-5-6-7-8-16-12-9-11(10-17)13(18)15(20)14(12)19/h9,12-20H,2-8,10H2,1H3/t12-,13+,14+,15+/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid PDB UniChem Similars	PDB Article PubMed	300	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Amicus Therapeutics Curated by ChEMBL					Assay Description Inhibition of human beta galactosidase				J Med Chem 56: 2705-25 (2013) Article DOI: 10.1021/jm301557k BindingDB Entry DOI: 10.7270/Q26111N4
					More data for this Ligand-Target Pair				3D Structure (crystal)
Sodium/glucose cotransporter 2 (Homo sapiens (Human))	BDBM50153308 (1-[2-Amino-4-methyl-6-(3,4,5-trihydroxy-6-hydroxym...) Show SMILES Cc1cc(N)c(C(=O)CCc2ccc3ccccc3c2)c(O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)c1 Show InChI InChI=1S/C26H29NO7/c1-14-10-18(27)22(19(29)9-7-15-6-8-16-4-2-3-5-17(16)12-15)20(11-14)33-26-25(32)24(31)23(30)21(13-28)34-26/h2-6,8,10-12,21,23-26,28,30-32H,7,9,13,27H2,1H3/t21-,23-,24+,25-,26-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL KEGG PC cid PC sid UniChem Similars	Article PubMed	520	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Johnson & Johnson Pharmaceutical Research and Development Curated by ChEMBL					Assay Description In vitro inhibition of Na-dependent [14C]-AMG uptake in CHO-K1 cells expressing human sodium glucose co-transporter 2				Bioorg Med Chem Lett 14: 5121-5 (2004) Article DOI: 10.1016/j.bmcl.2004.07.082 BindingDB Entry DOI: 10.7270/Q2VD6XX2
					More data for this Ligand-Target Pair
Sodium/glucose cotransporter 1 (Homo sapiens (Human))	BDBM50153313 (3-Cyclohexyl-1-[2-hydroxy-4-methyl-6-(3,4,5-trihyd...) Show SMILES Cc1cc(O)c(C(=O)CCC2CCCCC2)c(O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)c1 Show InChI InChI=1S/C22H32O8/c1-12-9-15(25)18(14(24)8-7-13-5-3-2-4-6-13)16(10-12)29-22-21(28)20(27)19(26)17(11-23)30-22/h9-10,13,17,19-23,25-28H,2-8,11H2,1H3/t17-,19-,20+,21-,22-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL KEGG PC cid PC sid UniChem Similars	Article PubMed	1.08E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Johnson & Johnson Pharmaceutical Research and Development Curated by ChEMBL					Assay Description In vitro inhibition of Na-dependent [14C]-AMG uptake in CHO-K1 cells expressing human sodium glucose co-transporter 1				Bioorg Med Chem Lett 14: 5121-5 (2004) Article DOI: 10.1016/j.bmcl.2004.07.082 BindingDB Entry DOI: 10.7270/Q2VD6XX2
					More data for this Ligand-Target Pair
Sodium/glucose cotransporter 2 (Homo sapiens (Human))	BDBM50153297 (1-[2-Amino-4-methyl-6-(3,4,5-trihydroxy-6-hydroxym...) Show SMILES CCOc1ccc(CCC(=O)c2c(N)cc(C)cc2O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)cc1 Show InChI InChI=1S/C24H31NO8/c1-3-31-15-7-4-14(5-8-15)6-9-17(27)20-16(25)10-13(2)11-18(20)32-24-23(30)22(29)21(28)19(12-26)33-24/h4-5,7-8,10-11,19,21-24,26,28-30H,3,6,9,12,25H2,1-2H3/t19-,21-,22+,23-,24-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL KEGG PC cid PC sid UniChem Similars	Article PubMed	1.28E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Johnson & Johnson Pharmaceutical Research and Development Curated by ChEMBL					Assay Description In vitro inhibition of Na-dependent [14C]-AMG uptake in CHO-K1 cells expressing human sodium glucose co-transporter 2				Bioorg Med Chem Lett 14: 5121-5 (2004) Article DOI: 10.1016/j.bmcl.2004.07.082 BindingDB Entry DOI: 10.7270/Q2VD6XX2
					More data for this Ligand-Target Pair
Sodium/glucose cotransporter 1 (Homo sapiens (Human))	BDBM50153312 (1-[2-Hydroxy-4-methyl-6-(3,4,5-trihydroxy-6-hydrox...) Show SMILES Cc1cc(O)c(C(=O)CCc2ccc3ccccc3c2)c(O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)c1 Show InChI InChI=1S/C26H28O8/c1-14-10-19(29)22(18(28)9-7-15-6-8-16-4-2-3-5-17(16)12-15)20(11-14)33-26-25(32)24(31)23(30)21(13-27)34-26/h2-6,8,10-12,21,23-27,29-32H,7,9,13H2,1H3/t21-,23-,24+,25-,26-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL KEGG PC cid PC sid UniChem Similars	Article PubMed	1.32E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Johnson & Johnson Pharmaceutical Research and Development Curated by ChEMBL					Assay Description In vitro inhibition of Na-dependent [14C]-AMG uptake in CHO-K1 cells expressing human sodium glucose co-transporter 1				Bioorg Med Chem Lett 14: 5121-5 (2004) Article DOI: 10.1016/j.bmcl.2004.07.082 BindingDB Entry DOI: 10.7270/Q2VD6XX2
					More data for this Ligand-Target Pair
Lysosomal acid glucosylceramidase (Homo sapiens (Human))	BDBM108423 (US8604206, (3R,4R,5R)-5((S)-hydroxy(phenyl)methyl)...) Show SMILES O[C@@H]([C@H]1CNC[C@@H](O)[C@@H]1O)c1ccccc1 Show InChI InChI=1S/C12H17NO3/c14-10-7-13-6-9(12(10)16)11(15)8-4-2-1-3-5-8/h1-5,9-16H,6-7H2/t9-,10-,11-,12-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	1.36E+3	n/a	3.29E+3	n/a	n/a	n/a	n/a	5.2	n/a
Amicus Therapeutics, Inc. US Patent					Assay Description The enzyme inhibition assays used monitored the ability of a test compound to bind and prevent the hydrolysis of a fluorogenic substrate in a concent...				US Patent US8604206 (2013) BindingDB Entry DOI: 10.7270/Q2MS3RDR
					More data for this Ligand-Target Pair
Sodium/glucose cotransporter 1 (Homo sapiens (Human))	BDBM50153306 (1-[2-Hydroxy-4-methyl-6-(3,4,5-trihydroxy-6-hydrox...) Show SMILES Cc1cc(O)c(C(=O)CCc2ccsc2)c(O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)c1 Show InChI InChI=1S/C20H24O8S/c1-10-6-13(23)16(12(22)3-2-11-4-5-29-9-11)14(7-10)27-20-19(26)18(25)17(24)15(8-21)28-20/h4-7,9,15,17-21,23-26H,2-3,8H2,1H3/t15-,17-,18+,19-,20-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL KEGG PC cid PC sid UniChem Similars	Article PubMed	1.38E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Johnson & Johnson Pharmaceutical Research and Development Curated by ChEMBL					Assay Description In vitro inhibition of Na-dependent [14C]-AMG uptake in CHO-K1 cells expressing human sodium glucose co-transporter 1				Bioorg Med Chem Lett 14: 5121-5 (2004) Article DOI: 10.1016/j.bmcl.2004.07.082 BindingDB Entry DOI: 10.7270/Q2VD6XX2
					More data for this Ligand-Target Pair
Sodium/glucose cotransporter 1 (Homo sapiens (Human))	BDBM50153302 (3-(2,3-Dihydro-benzo[1,4]dioxin-6-yl)-1-[2-hydroxy...) Show SMILES Cc1cc(O)c(C(=O)CCc2ccc3OCCOc3c2)c(O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)c1 Show InChI InChI=1S/C24H28O10/c1-12-8-15(27)20(14(26)4-2-13-3-5-16-17(10-13)32-7-6-31-16)18(9-12)33-24-23(30)22(29)21(28)19(11-25)34-24/h3,5,8-10,19,21-25,27-30H,2,4,6-7,11H2,1H3/t19-,21-,22+,23-,24-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL KEGG PC cid PC sid UniChem Similars	Article PubMed	1.46E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Johnson & Johnson Pharmaceutical Research and Development Curated by ChEMBL					Assay Description In vitro inhibition of Na-dependent [14C]-AMG uptake in CHO-K1 cells expressing human sodium glucose co-transporter 1				Bioorg Med Chem Lett 14: 5121-5 (2004) Article DOI: 10.1016/j.bmcl.2004.07.082 BindingDB Entry DOI: 10.7270/Q2VD6XX2
					More data for this Ligand-Target Pair
Sodium/glucose cotransporter 1 (Homo sapiens (Human))	BDBM50153301 (3-(4-Ethoxy-phenyl)-1-[2-hydroxy-4-methyl-6-(3,4,5...) Show SMILES CCOc1ccc(CCC(=O)c2c(O)cc(C)cc2O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)cc1 Show InChI InChI=1S/C24H30O9/c1-3-31-15-7-4-14(5-8-15)6-9-16(26)20-17(27)10-13(2)11-18(20)32-24-23(30)22(29)21(28)19(12-25)33-24/h4-5,7-8,10-11,19,21-25,27-30H,3,6,9,12H2,1-2H3/t19-,21-,22+,23-,24-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL KEGG PC cid PC sid UniChem Similars	Article PubMed	1.57E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Johnson & Johnson Pharmaceutical Research and Development Curated by ChEMBL					Assay Description In vitro inhibition of Na-dependent [14C]-AMG uptake in CHO-K1 cells expressing human sodium glucose co-transporter 1				Bioorg Med Chem Lett 14: 5121-5 (2004) Article DOI: 10.1016/j.bmcl.2004.07.082 BindingDB Entry DOI: 10.7270/Q2VD6XX2
					More data for this Ligand-Target Pair
Sodium/glucose cotransporter 2 (Homo sapiens (Human))	BDBM50153300 (1-[2-Chloro-6-(3,4,5-trihydroxy-6-hydroxymethyl-te...) Show SMILES CCOc1ccc(CCC(=O)c2c(Cl)cccc2O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)cc1 Show InChI InChI=1S/C23H27ClO8/c1-2-30-14-9-6-13(7-10-14)8-11-16(26)19-15(24)4-3-5-17(19)31-23-22(29)21(28)20(27)18(12-25)32-23/h3-7,9-10,18,20-23,25,27-29H,2,8,11-12H2,1H3/t18-,20-,21+,22-,23-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL KEGG PC cid PC sid UniChem Similars	Article PubMed	>1.70E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Johnson & Johnson Pharmaceutical Research and Development Curated by ChEMBL					Assay Description In vitro inhibition of Na-dependent [14C]-AMG uptake in CHO-K1 cells expressing human sodium glucose co-transporter 2				Bioorg Med Chem Lett 14: 5121-5 (2004) Article DOI: 10.1016/j.bmcl.2004.07.082 BindingDB Entry DOI: 10.7270/Q2VD6XX2
					More data for this Ligand-Target Pair
Sodium/glucose cotransporter 2 (Homo sapiens (Human))	BDBM50153310 (1-[2-Chloro-6-(3,4,5-trihydroxy-6-hydroxymethyl-te...) Show SMILES OC[C@H]1O[C@@H](Oc2cccc(Cl)c2C(=O)CCc2ccc3ccccc3c2)[C@H](O)[C@@H](O)[C@@H]1O Show InChI InChI=1S/C25H25ClO7/c26-17-6-3-7-19(32-25-24(31)23(30)22(29)20(13-27)33-25)21(17)18(28)11-9-14-8-10-15-4-1-2-5-16(15)12-14/h1-8,10,12,20,22-25,27,29-31H,9,11,13H2/t20-,22-,23+,24-,25-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL KEGG PC cid PC sid UniChem Similars	Article PubMed	>1.70E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Johnson & Johnson Pharmaceutical Research and Development Curated by ChEMBL					Assay Description In vitro inhibition of Na-dependent [14C]-AMG uptake in CHO-K1 cells expressing human sodium glucose co-transporter 2				Bioorg Med Chem Lett 14: 5121-5 (2004) Article DOI: 10.1016/j.bmcl.2004.07.082 BindingDB Entry DOI: 10.7270/Q2VD6XX2
					More data for this Ligand-Target Pair
Sodium/glucose cotransporter 2 (Homo sapiens (Human))	BDBM50153295 (1-[2-Chloro-6-(3,4,5-trihydroxy-6-hydroxymethyl-te...) Show SMILES OC[C@H]1O[C@@H](Oc2cccc(Cl)c2C(=O)CCc2ccc3OCCOc3c2)[C@H](O)[C@@H](O)[C@@H]1O Show InChI InChI=1S/C23H25ClO9/c24-13-2-1-3-16(32-23-22(29)21(28)20(27)18(11-25)33-23)19(13)14(26)6-4-12-5-7-15-17(10-12)31-9-8-30-15/h1-3,5,7,10,18,20-23,25,27-29H,4,6,8-9,11H2/t18-,20-,21+,22-,23-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL KEGG PC cid PC sid UniChem Similars	Article PubMed	>1.70E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Johnson & Johnson Pharmaceutical Research and Development Curated by ChEMBL					Assay Description In vitro inhibition of Na-dependent [14C]-AMG uptake in CHO-K1 cells expressing human sodium glucose co-transporter 2				Bioorg Med Chem Lett 14: 5121-5 (2004) Article DOI: 10.1016/j.bmcl.2004.07.082 BindingDB Entry DOI: 10.7270/Q2VD6XX2
					More data for this Ligand-Target Pair
Sodium/glucose cotransporter 1 (Homo sapiens (Human))	BDBM50153292 (1-[4-Fluoro-2-hydroxy-6-(3,4,5-trihydroxy-6-hydrox...) Show SMILES OC[C@H]1O[C@@H](Oc2cc(F)cc(O)c2C(=O)CCc2ccc3ccccc3c2)[C@H](O)[C@@H](O)[C@@H]1O Show InChI InChI=1S/C25H25FO8/c26-16-10-18(29)21(17(28)8-6-13-5-7-14-3-1-2-4-15(14)9-13)19(11-16)33-25-24(32)23(31)22(30)20(12-27)34-25/h1-5,7,9-11,20,22-25,27,29-32H,6,8,12H2/t20-,22-,23+,24-,25-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL KEGG PC cid PC sid UniChem Similars	Article PubMed	3.69E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Johnson & Johnson Pharmaceutical Research and Development Curated by ChEMBL					Assay Description In vitro inhibition of Na-dependent [14C]-AMG uptake in CHO-K1 cells expressing human sodium glucose co-transporter 1				Bioorg Med Chem Lett 14: 5121-5 (2004) Article DOI: 10.1016/j.bmcl.2004.07.082 BindingDB Entry DOI: 10.7270/Q2VD6XX2
					More data for this Ligand-Target Pair
Sodium/glucose cotransporter 1 (Homo sapiens (Human))	BDBM50153293 (1-[4-Chloro-2-hydroxy-6-(3,4,5-trihydroxy-6-hydrox...) Show SMILES OC[C@H]1O[C@@H](Oc2cc(Cl)cc(O)c2C(=O)CCc2ccc3OCCOc3c2)[C@H](O)[C@@H](O)[C@@H]1O Show InChI InChI=1S/C23H25ClO10/c24-12-8-14(27)19(13(26)3-1-11-2-4-15-16(7-11)32-6-5-31-15)17(9-12)33-23-22(30)21(29)20(28)18(10-25)34-23/h2,4,7-9,18,20-23,25,27-30H,1,3,5-6,10H2/t18-,20-,21+,22-,23-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL KEGG PC cid PC sid UniChem Similars	Article PubMed	3.75E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Johnson & Johnson Pharmaceutical Research and Development Curated by ChEMBL					Assay Description In vitro inhibition of Na-dependent [14C]-AMG uptake in CHO-K1 cells expressing human sodium glucose co-transporter 1				Bioorg Med Chem Lett 14: 5121-5 (2004) Article DOI: 10.1016/j.bmcl.2004.07.082 BindingDB Entry DOI: 10.7270/Q2VD6XX2
					More data for this Ligand-Target Pair

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