Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Translocator protein (Rattus norvegicus (rat)) | BDBM50350912 (CHEMBL1817978) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 0.440 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
CEA, I�BM Curated by ChEMBL | Assay Description Displacement of [3H]PK11195 from TSPO in rat heart membrane homogenate | Bioorg Med Chem Lett 21: 4819-22 (2011) Article DOI: 10.1016/j.bmcl.2011.06.048 BindingDB Entry DOI: 10.7270/Q200032R | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Translocator protein (Rattus norvegicus (rat)) | BDBM50185957 (CHEMBL205767 | N-(2-isopropoxybenzyl)-N-(4-chloro-...) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | 0.920 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Brain and Mind Research Institute Curated by ChEMBL | Assay Description Displacement of [3H]PK11195 from TSPO in rat cortex | J Med Chem 52: 581-92 (2009) Article DOI: 10.1021/jm8011678 BindingDB Entry DOI: 10.7270/Q2222VP0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Translocator protein (Homo sapiens (Human)) | BDBM50350912 (CHEMBL1817978) | KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 1.19 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
CEA, I�BM Curated by ChEMBL | Assay Description Displacement of [3H]PK11195 from TSPO in human HEK293 mitochondrial fraction | Bioorg Med Chem Lett 21: 4819-22 (2011) Article DOI: 10.1016/j.bmcl.2011.06.048 BindingDB Entry DOI: 10.7270/Q200032R | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Translocator protein (Rattus norvegicus (rat)) | BDBM22032 (1-(2-chlorophenyl)-N-methyl-N-(1-methylpropyl)isoq...) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | 1.80 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
CEA, I�BM Curated by ChEMBL | Assay Description Displacement of [3H]PK11195 from TSPO in rat heart membrane homogenate | Bioorg Med Chem Lett 21: 4819-22 (2011) Article DOI: 10.1016/j.bmcl.2011.06.048 BindingDB Entry DOI: 10.7270/Q200032R | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Translocator protein (Rattus norvegicus (rat)) | BDBM50253713 (CHEMBL461828 | N-benzyl-2-(5-chloro-2-(4-chlorophe...) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 3.33 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Brain and Mind Research Institute Curated by ChEMBL | Assay Description Displacement of [3H]PK11195 from TSPO in rat kidney membrane | J Med Chem 52: 581-92 (2009) Article DOI: 10.1021/jm8011678 BindingDB Entry DOI: 10.7270/Q2222VP0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Translocator protein (Rattus norvegicus (rat)) | BDBM50350912 (CHEMBL1817978) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 3.90 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
CEA, I�BM Curated by ChEMBL | Assay Description Displacement of [3H]PK11195 from TSPO in rat kidney mitochondrial fraction | Bioorg Med Chem Lett 21: 4819-22 (2011) Article DOI: 10.1016/j.bmcl.2011.06.048 BindingDB Entry DOI: 10.7270/Q200032R | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Translocator protein (Rattus norvegicus (rat)) | BDBM50045877 (2-(2-(4-fluorophenyl)-1H-indol-3-yl)-N,N-dihexylac...) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | 5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Brain and Mind Research Institute Curated by ChEMBL | Assay Description Displacement of [3H]PK11195 from TSPO in rat cortex | J Med Chem 52: 581-92 (2009) Article DOI: 10.1021/jm8011678 BindingDB Entry DOI: 10.7270/Q2222VP0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Translocator protein (Homo sapiens (Human)) | BDBM50327238 (2-[2-(4'-Methoxyphenyl)-5,7-dimethylpyrazolo[1,5-a...) | KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 6.70 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of New South Wales Curated by ChEMBL | Assay Description Displacement of [3H]PK11195 from TSPO in human T98G cell membranes incubated for 90 mins by competition radioligand binding assay | J Med Chem 58: 8743-9 (2015) Article DOI: 10.1021/acs.jmedchem.5b01288 BindingDB Entry DOI: 10.7270/Q2Q24222 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Translocator protein (Rattus norvegicus (rat)) | BDBM50243007 (2-(2-(4-(2-Fluoroethoxy)phenyl)-5,7-dimethylpyrazo...) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | 7 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Brain and Mind Research Institute Curated by ChEMBL | Assay Description Displacement of [3H]PK11195 from TSPO in rat cortex | J Med Chem 52: 581-92 (2009) Article DOI: 10.1021/jm8011678 BindingDB Entry DOI: 10.7270/Q2222VP0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Translocator protein (Homo sapiens (Human)) | BDBM22032 (1-(2-chlorophenyl)-N-methyl-N-(1-methylpropyl)isoq...) | KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars | Article PubMed | 7.11 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
CEA, I�BM Curated by ChEMBL | Assay Description Displacement of [3H]PK11195 from TSPO in human HEK293 mitochondrial fraction | Bioorg Med Chem Lett 21: 4819-22 (2011) Article DOI: 10.1016/j.bmcl.2011.06.048 BindingDB Entry DOI: 10.7270/Q200032R | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Translocator protein (Homo sapiens (Human)) | BDBM50327238 (2-[2-(4'-Methoxyphenyl)-5,7-dimethylpyrazolo[1,5-a...) | KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 8.20 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of New South Wales Curated by ChEMBL | Assay Description Inhibition constant against Adenosine A2a receptor | J Med Chem 58: 8743-9 (2015) Article DOI: 10.1021/acs.jmedchem.5b01288 BindingDB Entry DOI: 10.7270/Q2Q24222 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Translocator protein (Rattus norvegicus (rat)) | BDBM22032 (1-(2-chlorophenyl)-N-methyl-N-(1-methylpropyl)isoq...) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | 9.30 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
CEA, I�BM Curated by ChEMBL | Assay Description Displacement of [3H]PK11195 from TSPO in rat kidney mitochondrial fraction | Bioorg Med Chem Lett 21: 4819-22 (2011) Article DOI: 10.1016/j.bmcl.2011.06.048 BindingDB Entry DOI: 10.7270/Q200032R | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Translocator protein (Homo sapiens (Human)) | BDBM50131400 (CHEMBL3634876) | KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 28 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of New South Wales Curated by ChEMBL | Assay Description Inhibition constant against Adenosine A2a receptor | J Med Chem 58: 8743-9 (2015) Article DOI: 10.1021/acs.jmedchem.5b01288 BindingDB Entry DOI: 10.7270/Q2Q24222 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Translocator protein (Homo sapiens (Human)) | BDBM50131380 (CHEMBL3634878) | KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 29 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of New South Wales Curated by ChEMBL | Assay Description Displacement of [3H]PK11195 from TSPO in human T98G cell membranes incubated for 90 mins by competition radioligand binding assay | J Med Chem 58: 8743-9 (2015) Article DOI: 10.1021/acs.jmedchem.5b01288 BindingDB Entry DOI: 10.7270/Q2Q24222 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Translocator protein (Homo sapiens (Human)) | BDBM50131380 (CHEMBL3634878) | KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 144 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of New South Wales Curated by ChEMBL | Assay Description Inhibition constant against Adenosine A2a receptor | J Med Chem 58: 8743-9 (2015) Article DOI: 10.1021/acs.jmedchem.5b01288 BindingDB Entry DOI: 10.7270/Q2Q24222 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Translocator protein (Homo sapiens (Human)) | BDBM50131399 (CHEMBL3634877) | KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 224 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of New South Wales Curated by ChEMBL | Assay Description Displacement of [3H]PK11195 from TSPO in human T98G cell membranes incubated for 90 mins by competition radioligand binding assay | J Med Chem 58: 8743-9 (2015) Article DOI: 10.1021/acs.jmedchem.5b01288 BindingDB Entry DOI: 10.7270/Q2Q24222 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Translocator protein (Homo sapiens (Human)) | BDBM50131399 (CHEMBL3634877) | KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 398 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of New South Wales Curated by ChEMBL | Assay Description Inhibition constant against Adenosine A2a receptor | J Med Chem 58: 8743-9 (2015) Article DOI: 10.1021/acs.jmedchem.5b01288 BindingDB Entry DOI: 10.7270/Q2Q24222 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Translocator protein (Homo sapiens (Human)) | BDBM50131400 (CHEMBL3634876) | KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 806 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of New South Wales Curated by ChEMBL | Assay Description Displacement of [3H]PK11195 from TSPO in human T98G cell membranes incubated for 90 mins by competition radioligand binding assay | J Med Chem 58: 8743-9 (2015) Article DOI: 10.1021/acs.jmedchem.5b01288 BindingDB Entry DOI: 10.7270/Q2Q24222 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Translocator protein (Homo sapiens (Human)) | BDBM50131379 (CHEMBL3634879) | KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of New South Wales Curated by ChEMBL | Assay Description Displacement of [3H]PK11195 from TSPO in human T98G cell membranes incubated for 90 mins by competition radioligand binding assay | J Med Chem 58: 8743-9 (2015) Article DOI: 10.1021/acs.jmedchem.5b01288 BindingDB Entry DOI: 10.7270/Q2Q24222 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Translocator protein (Homo sapiens (Human)) | BDBM50131379 (CHEMBL3634879) | KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of New South Wales Curated by ChEMBL | Assay Description Inhibition constant against Adenosine A2a receptor | J Med Chem 58: 8743-9 (2015) Article DOI: 10.1021/acs.jmedchem.5b01288 BindingDB Entry DOI: 10.7270/Q2Q24222 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Translocator protein (Rattus norvegicus (rat)) | BDBM22032 (1-(2-chlorophenyl)-N-methyl-N-(1-methylpropyl)isoq...) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | n/a | 0.600 | n/a | n/a | n/a | n/a | n/a |
Brain and Mind Research Institute Curated by ChEMBL | Assay Description Displacement of [3H]PK11195 from TSPO in rat cortex | J Med Chem 52: 581-92 (2009) Article DOI: 10.1021/jm8011678 BindingDB Entry DOI: 10.7270/Q2222VP0 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Translocator protein (Rattus norvegicus (rat)) | BDBM50255226 ((7-chloro-N,N,5-trimethyl-4-oxo-3-phenyl-3,5-dihyd...) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents | Article PubMed | n/a | n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a |
Brain and Mind Research Institute Curated by ChEMBL | Assay Description Displacement of [3H]SSR180575 from TSPO in rat cortex | J Med Chem 52: 581-92 (2009) Article DOI: 10.1021/jm8011678 BindingDB Entry DOI: 10.7270/Q2222VP0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Translocator protein (Rattus norvegicus (rat)) | BDBM22040 (4 -chlorodiazepam | 4' Cl-diazepam | 7-chloro-...) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | 1.10 | n/a | n/a | n/a | n/a | n/a |
Brain and Mind Research Institute Curated by ChEMBL | Assay Description Displacement of [3H]Ro5-4864 from TSPO in rat kainate lesioned striatum | J Med Chem 52: 581-92 (2009) Article DOI: 10.1021/jm8011678 BindingDB Entry DOI: 10.7270/Q2222VP0 | |||||||||||
More data for this Ligand-Target Pair |