Found 34 hits with Last Name = 'sevrin' and Initial = 'm' Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Gamma-aminobutyric acid receptor subunit alpha-5
(RAT) | BDBM26263
(Anexate | CHEMBL407 | FLUMAZENIL | Ro15-1788 | Rom...)Show InChI InChI=1S/C15H14FN3O3/c1-3-22-15(21)13-12-7-18(2)14(20)10-6-9(16)4-5-11(10)19(12)8-17-13/h4-6,8H,3,7H2,1-2H3 | PDB
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Article
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| 0.810 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Synthélabo
Curated by PDSP Ki Database
| |
J Biol Chem 274: 13370-4 (1999)
Article DOI: 10.1074/jbc.274.19.13370
BindingDB Entry DOI: 10.7270/Q2765CWZ |
More data for this
Ligand-Target Pair | 
3D Structure (crystal) |
Gamma-aminobutyric acid receptor subunit alpha-5
(RAT) | BDBM26263
(Anexate | CHEMBL407 | FLUMAZENIL | Ro15-1788 | Rom...)Show InChI InChI=1S/C15H14FN3O3/c1-3-22-15(21)13-12-7-18(2)14(20)10-6-9(16)4-5-11(10)19(12)8-17-13/h4-6,8H,3,7H2,1-2H3 | PDB
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| 1.39 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Synthélabo
Curated by PDSP Ki Database
| |
J Biol Chem 274: 13370-4 (1999)
Article DOI: 10.1074/jbc.274.19.13370
BindingDB Entry DOI: 10.7270/Q2765CWZ |
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
Gamma-aminobutyric acid receptor subunit alpha-1
(Rattus norvegicus (Rat)) | BDBM26263
(Anexate | CHEMBL407 | FLUMAZENIL | Ro15-1788 | Rom...)Show InChI InChI=1S/C15H14FN3O3/c1-3-22-15(21)13-12-7-18(2)14(20)10-6-9(16)4-5-11(10)19(12)8-17-13/h4-6,8H,3,7H2,1-2H3 | PDB
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| 1.52 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Synthélabo
Curated by PDSP Ki Database
| |
J Biol Chem 274: 13370-4 (1999)
Article DOI: 10.1074/jbc.274.19.13370
BindingDB Entry DOI: 10.7270/Q2765CWZ |
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
Gamma-aminobutyric acid receptor subunit alpha-5
(RAT) | BDBM26263
(Anexate | CHEMBL407 | FLUMAZENIL | Ro15-1788 | Rom...)Show InChI InChI=1S/C15H14FN3O3/c1-3-22-15(21)13-12-7-18(2)14(20)10-6-9(16)4-5-11(10)19(12)8-17-13/h4-6,8H,3,7H2,1-2H3 | PDB
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| 1.52 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Synthélabo
Curated by PDSP Ki Database
| |
J Biol Chem 274: 13370-4 (1999)
Article DOI: 10.1074/jbc.274.19.13370
BindingDB Entry DOI: 10.7270/Q2765CWZ |
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
Gamma-aminobutyric acid receptor subunit alpha-5
(RAT) | BDBM26263
(Anexate | CHEMBL407 | FLUMAZENIL | Ro15-1788 | Rom...)Show InChI InChI=1S/C15H14FN3O3/c1-3-22-15(21)13-12-7-18(2)14(20)10-6-9(16)4-5-11(10)19(12)8-17-13/h4-6,8H,3,7H2,1-2H3 | PDB
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| PDB
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| 1.79 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Synthélabo
Curated by PDSP Ki Database
| |
J Biol Chem 274: 13370-4 (1999)
Article DOI: 10.1074/jbc.274.19.13370
BindingDB Entry DOI: 10.7270/Q2765CWZ |
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
Gamma-aminobutyric acid receptor subunit alpha-2
(Rattus norvegicus (Rat)) | BDBM50000766
(CHEMBL12 | DIAZEPAM | US9271961, Diazepam)Show InChI InChI=1S/C16H13ClN2O/c1-19-14-8-7-12(17)9-13(14)16(18-10-15(19)20)11-5-3-2-4-6-11/h2-9H,10H2,1H3 | PDB
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| 4.80 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Sanofi Synthelabo
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 298: 753-68 (2001)
BindingDB Entry DOI: 10.7270/Q2KS6Q34 |
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
Gamma-aminobutyric acid receptor subunit alpha-1
(Rattus norvegicus (Rat)) | BDBM85806
(6-FLUOR-2-FENYL-9-METHYL-4-(PYRROLIDINE-1-CARBONYL...)Show SMILES Cn1c2ccc(F)cc2c2c(cn(-c3ccccc3)c(=O)c12)C(=O)N1CCCC1 Show InChI InChI=1S/C23H20FN3O2/c1-25-19-10-9-15(24)13-17(19)20-18(22(28)26-11-5-6-12-26)14-27(23(29)21(20)25)16-7-3-2-4-8-16/h2-4,7-10,13-14H,5-6,11-12H2,1H3 | PDB
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| 6.80 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Sanofi Synthelabo
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 298: 753-68 (2001)
BindingDB Entry DOI: 10.7270/Q2KS6Q34 |
More data for this
Ligand-Target Pair | |
Gamma-aminobutyric acid receptor subunit alpha-2
(Rattus norvegicus (Rat)) | BDBM50000766
(CHEMBL12 | DIAZEPAM | US9271961, Diazepam)Show InChI InChI=1S/C16H13ClN2O/c1-19-14-8-7-12(17)9-13(14)16(18-10-15(19)20)11-5-3-2-4-6-11/h2-9H,10H2,1H3 | PDB
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| 7.80 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Sanofi Synthelabo
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 298: 753-68 (2001)
BindingDB Entry DOI: 10.7270/Q2KS6Q34 |
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
Gamma-aminobutyric acid receptor subunit alpha-5
(RAT) | BDBM50000766
(CHEMBL12 | DIAZEPAM | US9271961, Diazepam)Show InChI InChI=1S/C16H13ClN2O/c1-19-14-8-7-12(17)9-13(14)16(18-10-15(19)20)11-5-3-2-4-6-11/h2-9H,10H2,1H3 | PDB
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| 9.80 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Sanofi Synthelabo
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 298: 753-68 (2001)
BindingDB Entry DOI: 10.7270/Q2KS6Q34 |
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
Gamma-aminobutyric acid receptor subunit alpha-2
(Rattus norvegicus (Rat)) | BDBM85806
(6-FLUOR-2-FENYL-9-METHYL-4-(PYRROLIDINE-1-CARBONYL...)Show SMILES Cn1c2ccc(F)cc2c2c(cn(-c3ccccc3)c(=O)c12)C(=O)N1CCCC1 Show InChI InChI=1S/C23H20FN3O2/c1-25-19-10-9-15(24)13-17(19)20-18(22(28)26-11-5-6-12-26)14-27(23(29)21(20)25)16-7-3-2-4-8-16/h2-4,7-10,13-14H,5-6,11-12H2,1H3 | PDB
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PC sid
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| 12.3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Sanofi Synthelabo
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 298: 753-68 (2001)
BindingDB Entry DOI: 10.7270/Q2KS6Q34 |
More data for this
Ligand-Target Pair | |
Gamma-aminobutyric acid receptor subunit alpha-5
(RAT) | BDBM50000766
(CHEMBL12 | DIAZEPAM | US9271961, Diazepam)Show InChI InChI=1S/C16H13ClN2O/c1-19-14-8-7-12(17)9-13(14)16(18-10-15(19)20)11-5-3-2-4-6-11/h2-9H,10H2,1H3 | PDB
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PubMed
| 13.4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Sanofi Synthelabo
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 298: 753-68 (2001)
BindingDB Entry DOI: 10.7270/Q2KS6Q34 |
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
Gamma-aminobutyric acid receptor subunit alpha-3
(RAT) | BDBM50000766
(CHEMBL12 | DIAZEPAM | US9271961, Diazepam)Show InChI InChI=1S/C16H13ClN2O/c1-19-14-8-7-12(17)9-13(14)16(18-10-15(19)20)11-5-3-2-4-6-11/h2-9H,10H2,1H3 | PDB
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| 13.9 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Sanofi Synthelabo
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 298: 753-68 (2001)
BindingDB Entry DOI: 10.7270/Q2KS6Q34 |
More data for this
Ligand-Target Pair | |
Gamma-aminobutyric acid receptor subunit alpha-1
(Rattus norvegicus (Rat)) | BDBM50000766
(CHEMBL12 | DIAZEPAM | US9271961, Diazepam)Show InChI InChI=1S/C16H13ClN2O/c1-19-14-8-7-12(17)9-13(14)16(18-10-15(19)20)11-5-3-2-4-6-11/h2-9H,10H2,1H3 | PDB
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| 14 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Sanofi Synthelabo
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 298: 753-68 (2001)
BindingDB Entry DOI: 10.7270/Q2KS6Q34 |
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
Gamma-aminobutyric acid receptor subunit alpha-1
(Rattus norvegicus (Rat)) | BDBM85806
(6-FLUOR-2-FENYL-9-METHYL-4-(PYRROLIDINE-1-CARBONYL...)Show SMILES Cn1c2ccc(F)cc2c2c(cn(-c3ccccc3)c(=O)c12)C(=O)N1CCCC1 Show InChI InChI=1S/C23H20FN3O2/c1-25-19-10-9-15(24)13-17(19)20-18(22(28)26-11-5-6-12-26)14-27(23(29)21(20)25)16-7-3-2-4-8-16/h2-4,7-10,13-14H,5-6,11-12H2,1H3 | PDB
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| 17 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Sanofi Synthelabo
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 298: 753-68 (2001)
BindingDB Entry DOI: 10.7270/Q2KS6Q34 |
More data for this
Ligand-Target Pair | |
Gamma-aminobutyric acid receptor subunit alpha-1
(Rattus norvegicus (Rat)) | BDBM26266
(Ambien | CHEMBL911 | Dalparan | N,N-dimethyl-2-[6-...)Show InChI InChI=1S/C19H21N3O/c1-13-5-8-15(9-6-13)19-16(11-18(23)21(3)4)22-12-14(2)7-10-17(22)20-19/h5-10,12H,11H2,1-4H3 | PDB
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| PDB
Article
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| 29.6 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Synthélabo
Curated by PDSP Ki Database
| |
J Biol Chem 274: 13370-4 (1999)
Article DOI: 10.1074/jbc.274.19.13370
BindingDB Entry DOI: 10.7270/Q2765CWZ |
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
Gamma-aminobutyric acid receptor subunit alpha-2
(Rattus norvegicus (Rat)) | BDBM85806
(6-FLUOR-2-FENYL-9-METHYL-4-(PYRROLIDINE-1-CARBONYL...)Show SMILES Cn1c2ccc(F)cc2c2c(cn(-c3ccccc3)c(=O)c12)C(=O)N1CCCC1 Show InChI InChI=1S/C23H20FN3O2/c1-25-19-10-9-15(24)13-17(19)20-18(22(28)26-11-5-6-12-26)14-27(23(29)21(20)25)16-7-3-2-4-8-16/h2-4,7-10,13-14H,5-6,11-12H2,1H3 | PDB
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| 73 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Sanofi Synthelabo
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 298: 753-68 (2001)
BindingDB Entry DOI: 10.7270/Q2KS6Q34 |
More data for this
Ligand-Target Pair | |
Gamma-aminobutyric acid receptor subunit alpha-3
(RAT) | BDBM85806
(6-FLUOR-2-FENYL-9-METHYL-4-(PYRROLIDINE-1-CARBONYL...)Show SMILES Cn1c2ccc(F)cc2c2c(cn(-c3ccccc3)c(=O)c12)C(=O)N1CCCC1 Show InChI InChI=1S/C23H20FN3O2/c1-25-19-10-9-15(24)13-17(19)20-18(22(28)26-11-5-6-12-26)14-27(23(29)21(20)25)16-7-3-2-4-8-16/h2-4,7-10,13-14H,5-6,11-12H2,1H3 | PDB
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| 80.3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Sanofi Synthelabo
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 298: 753-68 (2001)
BindingDB Entry DOI: 10.7270/Q2KS6Q34 |
More data for this
Ligand-Target Pair | |
Gamma-aminobutyric acid receptor subunit alpha-5
(RAT) | BDBM26266
(Ambien | CHEMBL911 | Dalparan | N,N-dimethyl-2-[6-...)Show InChI InChI=1S/C19H21N3O/c1-13-5-8-15(9-6-13)19-16(11-18(23)21(3)4)22-12-14(2)7-10-17(22)20-19/h5-10,12H,11H2,1-4H3 | PDB
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| 105 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Synthélabo
Curated by PDSP Ki Database
| |
J Biol Chem 274: 13370-4 (1999)
Article DOI: 10.1074/jbc.274.19.13370
BindingDB Entry DOI: 10.7270/Q2765CWZ |
More data for this
Ligand-Target Pair | |
Gamma-aminobutyric acid receptor subunit alpha-5
(RAT) | BDBM85806
(6-FLUOR-2-FENYL-9-METHYL-4-(PYRROLIDINE-1-CARBONYL...)Show SMILES Cn1c2ccc(F)cc2c2c(cn(-c3ccccc3)c(=O)c12)C(=O)N1CCCC1 Show InChI InChI=1S/C23H20FN3O2/c1-25-19-10-9-15(24)13-17(19)20-18(22(28)26-11-5-6-12-26)14-27(23(29)21(20)25)16-7-3-2-4-8-16/h2-4,7-10,13-14H,5-6,11-12H2,1H3 | PDB
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| 117 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Sanofi Synthelabo
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 298: 753-68 (2001)
BindingDB Entry DOI: 10.7270/Q2KS6Q34 |
More data for this
Ligand-Target Pair | |
Gamma-aminobutyric acid receptor subunit alpha-5
(RAT) | BDBM50026756
(3-Methyl-6-(3-trifluoromethyl-phenyl)-[1,2,4]triaz...)Show InChI InChI=1S/C13H9F3N4/c1-8-17-18-12-6-5-11(19-20(8)12)9-3-2-4-10(7-9)13(14,15)16/h2-7H,1H3 | PDB
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| 127 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Synthélabo
Curated by PDSP Ki Database
| |
J Biol Chem 274: 13370-4 (1999)
Article DOI: 10.1074/jbc.274.19.13370
BindingDB Entry DOI: 10.7270/Q2765CWZ |
More data for this
Ligand-Target Pair | |
Gamma-aminobutyric acid receptor subunit alpha-5
(RAT) | BDBM50026756
(3-Methyl-6-(3-trifluoromethyl-phenyl)-[1,2,4]triaz...)Show InChI InChI=1S/C13H9F3N4/c1-8-17-18-12-6-5-11(19-20(8)12)9-3-2-4-10(7-9)13(14,15)16/h2-7H,1H3 | PDB
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PubMed
| 157 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Synthélabo
Curated by PDSP Ki Database
| |
J Biol Chem 274: 13370-4 (1999)
Article DOI: 10.1074/jbc.274.19.13370
BindingDB Entry DOI: 10.7270/Q2765CWZ |
More data for this
Ligand-Target Pair | |
Gamma-aminobutyric acid receptor subunit alpha-5
(RAT) | BDBM85806
(6-FLUOR-2-FENYL-9-METHYL-4-(PYRROLIDINE-1-CARBONYL...)Show SMILES Cn1c2ccc(F)cc2c2c(cn(-c3ccccc3)c(=O)c12)C(=O)N1CCCC1 Show InChI InChI=1S/C23H20FN3O2/c1-25-19-10-9-15(24)13-17(19)20-18(22(28)26-11-5-6-12-26)14-27(23(29)21(20)25)16-7-3-2-4-8-16/h2-4,7-10,13-14H,5-6,11-12H2,1H3 | PDB
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| 215 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Sanofi Synthelabo
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 298: 753-68 (2001)
BindingDB Entry DOI: 10.7270/Q2KS6Q34 |
More data for this
Ligand-Target Pair | |
Gamma-aminobutyric acid receptor subunit alpha-5
(RAT) | BDBM50026756
(3-Methyl-6-(3-trifluoromethyl-phenyl)-[1,2,4]triaz...)Show InChI InChI=1S/C13H9F3N4/c1-8-17-18-12-6-5-11(19-20(8)12)9-3-2-4-10(7-9)13(14,15)16/h2-7H,1H3 | PDB
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| 333 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Synthélabo
Curated by PDSP Ki Database
| |
J Biol Chem 274: 13370-4 (1999)
Article DOI: 10.1074/jbc.274.19.13370
BindingDB Entry DOI: 10.7270/Q2765CWZ |
More data for this
Ligand-Target Pair | |
Gamma-aminobutyric acid receptor subunit alpha-5
(RAT) | BDBM50026756
(3-Methyl-6-(3-trifluoromethyl-phenyl)-[1,2,4]triaz...)Show InChI InChI=1S/C13H9F3N4/c1-8-17-18-12-6-5-11(19-20(8)12)9-3-2-4-10(7-9)13(14,15)16/h2-7H,1H3 | PDB
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| 447 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Synthélabo
Curated by PDSP Ki Database
| |
J Biol Chem 274: 13370-4 (1999)
Article DOI: 10.1074/jbc.274.19.13370
BindingDB Entry DOI: 10.7270/Q2765CWZ |
More data for this
Ligand-Target Pair | |
Gamma-aminobutyric acid receptor subunit alpha-5
(RAT) | BDBM26266
(Ambien | CHEMBL911 | Dalparan | N,N-dimethyl-2-[6-...)Show InChI InChI=1S/C19H21N3O/c1-13-5-8-15(9-6-13)19-16(11-18(23)21(3)4)22-12-14(2)7-10-17(22)20-19/h5-10,12H,11H2,1-4H3 | PDB
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| 829 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Synthélabo
Curated by PDSP Ki Database
| |
J Biol Chem 274: 13370-4 (1999)
Article DOI: 10.1074/jbc.274.19.13370
BindingDB Entry DOI: 10.7270/Q2765CWZ |
More data for this
Ligand-Target Pair | |
Gamma-aminobutyric acid receptor subunit alpha-5
(RAT) | BDBM26266
(Ambien | CHEMBL911 | Dalparan | N,N-dimethyl-2-[6-...)Show InChI InChI=1S/C19H21N3O/c1-13-5-8-15(9-6-13)19-16(11-18(23)21(3)4)22-12-14(2)7-10-17(22)20-19/h5-10,12H,11H2,1-4H3 | PDB
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| 3.82E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Synthélabo
Curated by PDSP Ki Database
| |
J Biol Chem 274: 13370-4 (1999)
Article DOI: 10.1074/jbc.274.19.13370
BindingDB Entry DOI: 10.7270/Q2765CWZ |
More data for this
Ligand-Target Pair | |
Gamma-aminobutyric acid receptor subunit alpha-5
(RAT) | BDBM26266
(Ambien | CHEMBL911 | Dalparan | N,N-dimethyl-2-[6-...)Show InChI InChI=1S/C19H21N3O/c1-13-5-8-15(9-6-13)19-16(11-18(23)21(3)4)22-12-14(2)7-10-17(22)20-19/h5-10,12H,11H2,1-4H3 | PDB
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| >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Synthélabo
Curated by PDSP Ki Database
| |
J Biol Chem 274: 13370-4 (1999)
Article DOI: 10.1074/jbc.274.19.13370
BindingDB Entry DOI: 10.7270/Q2765CWZ |
More data for this
Ligand-Target Pair | |
Gamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2
(Homo sapiens (Human)) | BDBM50290077
(CHEMBL73416 | N-[2-(4-Chloro-phenyl)-imidazo[1,2-a...)Show InChI InChI=1S/C19H20ClN3O/c1-3-6-18(24)22(2)13-16-19(14-8-10-15(20)11-9-14)21-17-7-4-5-12-23(16)17/h4-5,7-12H,3,6,13H2,1-2H3 | PDB
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| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
| n/a | n/a | 1.10 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
In vitro functional inhibitory potency prevention of ET-1 induced constriction of rat aortic rings (ETB receptors) |
Bioorg Med Chem Lett 7: 2277-2282 (1997)
Article DOI: 10.1016/S0960-894X(97)00404-6
BindingDB Entry DOI: 10.7270/Q2BK1CB0 |
More data for this
Ligand-Target Pair | |
Gamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2
(Homo sapiens (Human)) | BDBM50290077
(CHEMBL73416 | N-[2-(4-Chloro-phenyl)-imidazo[1,2-a...)Show InChI InChI=1S/C19H20ClN3O/c1-3-6-18(24)22(2)13-16-19(14-8-10-15(20)11-9-14)21-17-7-4-5-12-23(16)17/h4-5,7-12H,3,6,13H2,1-2H3 | PDB
UniProtKB/SwissProt
antibodypedia
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GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
| n/a | n/a | 1.10 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Compound was evaluated for in vitro functional inhibitory potency for prevention of ET-1 induced constriction of rat aortic rings (ETA receptors) |
Bioorg Med Chem Lett 7: 2277-2282 (1997)
Article DOI: 10.1016/S0960-894X(97)00404-6
BindingDB Entry DOI: 10.7270/Q2BK1CB0 |
More data for this
Ligand-Target Pair | |
Gamma-aminobutyric acid receptor subunit alpha-5
(Homo sapiens (Human)) | BDBM50290077
(CHEMBL73416 | N-[2-(4-Chloro-phenyl)-imidazo[1,2-a...)Show InChI InChI=1S/C19H20ClN3O/c1-3-6-18(24)22(2)13-16-19(14-8-10-15(20)11-9-14)21-17-7-4-5-12-23(16)17/h4-5,7-12H,3,6,13H2,1-2H3 | PDB
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| CHEMBL
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| n/a | n/a | 2.70 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Receptor binding affinity was determined in a radioligand binding assay against [125I]ET1 with recombinant human ETA receptor, expressed in baculovir... |
Bioorg Med Chem Lett 7: 2277-2282 (1997)
Article DOI: 10.1016/S0960-894X(97)00404-6
BindingDB Entry DOI: 10.7270/Q2BK1CB0 |
More data for this
Ligand-Target Pair | |
Gamma-aminobutyric acid receptor subunit alpha-5
(Homo sapiens (Human)) | BDBM50290077
(CHEMBL73416 | N-[2-(4-Chloro-phenyl)-imidazo[1,2-a...)Show InChI InChI=1S/C19H20ClN3O/c1-3-6-18(24)22(2)13-16-19(14-8-10-15(20)11-9-14)21-17-7-4-5-12-23(16)17/h4-5,7-12H,3,6,13H2,1-2H3 | PDB
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| n/a | n/a | 4.60 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of [3H]-Flumazenil binding to recombinant GABA-A receptor alpha-5 subunit in spinal cord |
Bioorg Med Chem Lett 7: 2277-2282 (1997)
Article DOI: 10.1016/S0960-894X(97)00404-6
BindingDB Entry DOI: 10.7270/Q2BK1CB0 |
More data for this
Ligand-Target Pair | |
Gamma-aminobutyric acid receptor subunit alpha-1
(Homo sapiens (Human)) | BDBM26266
(Ambien | CHEMBL911 | Dalparan | N,N-dimethyl-2-[6-...)Show InChI InChI=1S/C19H21N3O/c1-13-5-8-15(9-6-13)19-16(11-18(23)21(3)4)22-12-14(2)7-10-17(22)20-19/h5-10,12H,11H2,1-4H3 | PDB
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| DrugBank
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Article
| n/a | n/a | 14 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of [3H]-Flumazenil binding to recombinant GABA-A receptor alpha-1 subunit in cerebellum |
Bioorg Med Chem Lett 7: 2277-2282 (1997)
Article DOI: 10.1016/S0960-894X(97)00404-6
BindingDB Entry DOI: 10.7270/Q2BK1CB0 |
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
Gamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2
(Homo sapiens (Human)) | BDBM26266
(Ambien | CHEMBL911 | Dalparan | N,N-dimethyl-2-[6-...)Show InChI InChI=1S/C19H21N3O/c1-13-5-8-15(9-6-13)19-16(11-18(23)21(3)4)22-12-14(2)7-10-17(22)20-19/h5-10,12H,11H2,1-4H3 | PDB
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| PDB
Article
| n/a | n/a | 46 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Compound was evaluated for in vitro functional inhibitory potency for prevention of ET-1 induced constriction of rat aortic rings (ETA receptors) |
Bioorg Med Chem Lett 7: 2277-2282 (1997)
Article DOI: 10.1016/S0960-894X(97)00404-6
BindingDB Entry DOI: 10.7270/Q2BK1CB0 |
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
Gamma-aminobutyric acid receptor subunit alpha-1
(Homo sapiens (Human)) | BDBM26266
(Ambien | CHEMBL911 | Dalparan | N,N-dimethyl-2-[6-...)Show InChI InChI=1S/C19H21N3O/c1-13-5-8-15(9-6-13)19-16(11-18(23)21(3)4)22-12-14(2)7-10-17(22)20-19/h5-10,12H,11H2,1-4H3 | PDB
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| n/a | n/a | 130 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Compound was evaluated for in vitro functional inhibitory potency for prevention of sarafotoxin S6c induced constriction of rat tracheal rings (ETB r... |
Bioorg Med Chem Lett 7: 2277-2282 (1997)
Article DOI: 10.1016/S0960-894X(97)00404-6
BindingDB Entry DOI: 10.7270/Q2BK1CB0 |
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
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