Compile Data Set for Download or QSAR

Found 53 hits with Last Name = 'stone' and Initial = 'rm'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Receptor-type tyrosine-protein kinase FLT3 (Homo sapiens (Human))	BDBM50300690 (1-(5-Tert-Butyl-1,2-Oxazol-3-Yl)-3-(4-{7-[2-(Morph...) Show SMILES CC(C)(C)c1cc(NC(=O)Nc2ccc(cc2)-c2cn3c(n2)sc2cc(OCCN4CCOCC4)ccc32)no1 Show InChI InChI=1S/C29H32N6O4S/c1-29(2,3)25-17-26(33-39-25)32-27(36)30-20-6-4-19(5-7-20)22-18-35-23-9-8-21(16-24(23)40-28(35)31-22)38-15-12-34-10-13-37-14-11-34/h4-9,16-18H,10-15H2,1-3H3,(H2,30,32,33,36)	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
Harvard Medical School Curated by ChEMBL					Assay Description Competitive inhibition of FLT3 ITD mutant (unknown origin) in presence of ATP				ACS Med Chem Lett 7: 476-81 (2016) Article DOI: 10.1021/acsmedchemlett.5b00498 BindingDB Entry DOI: 10.7270/Q2HD7XJD
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 (Homo sapiens (Human))	BDBM50177715 (CHEMBL3815054) Show SMILES CN(C)CCCn1cc(cn1)-c1ccc2C(=O)c3c([nH]c4cc(ccc34)-c3cn[nH]c3)-c2c1 Show InChI InChI=1S/C26H24N6O/c1-31(2)8-3-9-32-15-19(14-29-32)16-4-6-20-22(10-16)25-24(26(20)33)21-7-5-17(11-23(21)30-25)18-12-27-28-13-18/h4-7,10-15,30H,3,8-9H2,1-2H3,(H,27,28)	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
Harvard Medical School Curated by ChEMBL					Assay Description Inhibition of FLT3 ITD mutant in human MOLM13 cells assessed as reduction in cell viability a after 3 days by cell titer glo assay				ACS Med Chem Lett 7: 476-81 (2016) Article DOI: 10.1021/acsmedchemlett.5b00498 BindingDB Entry DOI: 10.7270/Q2HD7XJD
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 (Homo sapiens (Human))	BDBM185149 (1-[2-[5-[(3-methyloxetan-3-yl)methoxy]benzimidazol...) Show SMILES CC1(COc2ccc3n(cnc3c2)-c2ccc3cccc(N4CCC(N)CC4)c3n2)COC1 Show InChI InChI=1S/C26H29N5O2/c1-26(14-32-15-26)16-33-20-6-7-22-21(13-20)28-17-31(22)24-8-5-18-3-2-4-23(25(18)29-24)30-11-9-19(27)10-12-30/h2-8,13,17,19H,9-12,14-16,27H2,1H3	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem	Article PubMed	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
Harvard Medical School Curated by ChEMBL					Assay Description Competitive inhibition of FLT3 ITD mutant (unknown origin) in presence of ATP				ACS Med Chem Lett 7: 476-81 (2016) Article DOI: 10.1021/acsmedchemlett.5b00498 BindingDB Entry DOI: 10.7270/Q2HD7XJD
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 (Homo sapiens (Human))	BDBM50177715 (CHEMBL3815054) Show SMILES CN(C)CCCn1cc(cn1)-c1ccc2C(=O)c3c([nH]c4cc(ccc34)-c3cn[nH]c3)-c2c1 Show InChI InChI=1S/C26H24N6O/c1-31(2)8-3-9-32-15-19(14-29-32)16-4-6-20-22(10-16)25-24(26(20)33)21-7-5-17(11-23(21)30-25)18-12-27-28-13-18/h4-7,10-15,30H,3,8-9H2,1-2H3,(H,27,28)	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
Harvard Medical School Curated by ChEMBL					Assay Description Competitive inhibition of FLT3 D835Y mutant (unknown origin) in presence of ATP				ACS Med Chem Lett 7: 476-81 (2016) Article DOI: 10.1021/acsmedchemlett.5b00498 BindingDB Entry DOI: 10.7270/Q2HD7XJD
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 (Homo sapiens (Human))	BDBM185149 (1-[2-[5-[(3-methyloxetan-3-yl)methoxy]benzimidazol...) Show SMILES CC1(COc2ccc3n(cnc3c2)-c2ccc3cccc(N4CCC(N)CC4)c3n2)COC1 Show InChI InChI=1S/C26H29N5O2/c1-26(14-32-15-26)16-33-20-6-7-22-21(13-20)28-17-31(22)24-8-5-18-3-2-4-23(25(18)29-24)30-11-9-19(27)10-12-30/h2-8,13,17,19H,9-12,14-16,27H2,1H3	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem	Article PubMed	n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
Harvard Medical School Curated by ChEMBL					Assay Description Competitive inhibition of FLT3 D835Y mutant (unknown origin) in presence of ATP				ACS Med Chem Lett 7: 476-81 (2016) Article DOI: 10.1021/acsmedchemlett.5b00498 BindingDB Entry DOI: 10.7270/Q2HD7XJD
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 (Homo sapiens (Human))	BDBM50177715 (CHEMBL3815054) Show SMILES CN(C)CCCn1cc(cn1)-c1ccc2C(=O)c3c([nH]c4cc(ccc34)-c3cn[nH]c3)-c2c1 Show InChI InChI=1S/C26H24N6O/c1-31(2)8-3-9-32-15-19(14-29-32)16-4-6-20-22(10-16)25-24(26(20)33)21-7-5-17(11-23(21)30-25)18-12-27-28-13-18/h4-7,10-15,30H,3,8-9H2,1-2H3,(H,27,28)	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
Harvard Medical School Curated by ChEMBL					Assay Description Inhibition of FLT3 D835Y mutant (unknown origin) transduced in mouse Ba/F3 cells assessed as reduction in cell viability after 3 days by cell titer g...				ACS Med Chem Lett 7: 476-81 (2016) Article DOI: 10.1021/acsmedchemlett.5b00498 BindingDB Entry DOI: 10.7270/Q2HD7XJD
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 (Homo sapiens (Human))	BDBM50177716 (CHEMBL3813873 | US11679110, Compound Pexidartinib ...) Show SMILES FC(F)(F)c1ccc(CNc2ccc(Cc3c[nH]c4ncc(Cl)cc34)cn2)cn1 Show InChI InChI=1S/C20H15ClF3N5/c21-15-6-16-14(10-28-19(16)29-11-15)5-12-2-4-18(26-7-12)27-9-13-1-3-17(25-8-13)20(22,23)24/h1-4,6-8,10-11H,5,9H2,(H,26,27)(H,28,29)	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
Harvard Medical School Curated by ChEMBL					Assay Description Competitive inhibition of FLT3 D835Y mutant (unknown origin) in presence of ATP				ACS Med Chem Lett 7: 476-81 (2016) Article DOI: 10.1021/acsmedchemlett.5b00498 BindingDB Entry DOI: 10.7270/Q2HD7XJD
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 (Homo sapiens (Human))	BDBM50177779 (CHEMBL3814908) Show SMILES CN(C)CCCn1cc(cn1)-c1ccc-2c(c1)C(=O)c1c-2[nH]c2cc(ccc12)-c1cn[nH]c1 Show InChI InChI=1S/C26H24N6O/c1-31(2)8-3-9-32-15-19(14-29-32)16-4-6-20-22(10-16)26(33)24-21-7-5-17(18-12-27-28-13-18)11-23(21)30-25(20)24/h4-7,10-15,30H,3,8-9H2,1-2H3,(H,27,28)	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	6	n/a	n/a	n/a	n/a	n/a	n/a
Harvard Medical School Curated by ChEMBL					Assay Description Inhibition of FLT3 D835Y mutant (unknown origin) transduced in mouse Ba/F3 cells assessed as reduction in cell viability after 3 days by cell titer g...				ACS Med Chem Lett 7: 476-81 (2016) Article DOI: 10.1021/acsmedchemlett.5b00498 BindingDB Entry DOI: 10.7270/Q2HD7XJD
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 (Homo sapiens (Human))	BDBM50177715 (CHEMBL3815054) Show SMILES CN(C)CCCn1cc(cn1)-c1ccc2C(=O)c3c([nH]c4cc(ccc34)-c3cn[nH]c3)-c2c1 Show InChI InChI=1S/C26H24N6O/c1-31(2)8-3-9-32-15-19(14-29-32)16-4-6-20-22(10-16)25-24(26(20)33)21-7-5-17(11-23(21)30-25)18-12-27-28-13-18/h4-7,10-15,30H,3,8-9H2,1-2H3,(H,27,28)	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
Harvard Medical School Curated by ChEMBL					Assay Description Competitive inhibition of FLT3 ITD mutant (unknown origin) in presence of ATP				ACS Med Chem Lett 7: 476-81 (2016) Article DOI: 10.1021/acsmedchemlett.5b00498 BindingDB Entry DOI: 10.7270/Q2HD7XJD
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 (Homo sapiens (Human))	BDBM50177715 (CHEMBL3815054) Show SMILES CN(C)CCCn1cc(cn1)-c1ccc2C(=O)c3c([nH]c4cc(ccc34)-c3cn[nH]c3)-c2c1 Show InChI InChI=1S/C26H24N6O/c1-31(2)8-3-9-32-15-19(14-29-32)16-4-6-20-22(10-16)25-24(26(20)33)21-7-5-17(11-23(21)30-25)18-12-27-28-13-18/h4-7,10-15,30H,3,8-9H2,1-2H3,(H,27,28)	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
Harvard Medical School Curated by ChEMBL					Assay Description Inhibition of FLT3 ITD mutant (unknown origin) transduced in mouse Ba/F3 cells assessed as reduction in cell viability after 3 days by cell titer glo...				ACS Med Chem Lett 7: 476-81 (2016) Article DOI: 10.1021/acsmedchemlett.5b00498 BindingDB Entry DOI: 10.7270/Q2HD7XJD
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 (Homo sapiens (Human))	BDBM50177715 (CHEMBL3815054) Show SMILES CN(C)CCCn1cc(cn1)-c1ccc2C(=O)c3c([nH]c4cc(ccc34)-c3cn[nH]c3)-c2c1 Show InChI InChI=1S/C26H24N6O/c1-31(2)8-3-9-32-15-19(14-29-32)16-4-6-20-22(10-16)25-24(26(20)33)21-7-5-17(11-23(21)30-25)18-12-27-28-13-18/h4-7,10-15,30H,3,8-9H2,1-2H3,(H,27,28)	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	11	n/a	n/a	n/a	n/a	n/a	n/a
Harvard Medical School Curated by ChEMBL					Assay Description Inhibition of FLT3 ITD mutant in human MOLM14 cells assessed as reduction in cell viability after 3 days by cell titer glo assay				ACS Med Chem Lett 7: 476-81 (2016) Article DOI: 10.1021/acsmedchemlett.5b00498 BindingDB Entry DOI: 10.7270/Q2HD7XJD
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 (Homo sapiens (Human))	BDBM50177721 (CHEMBL3814657) Show SMILES CN(C)CCCn1cc(cn1)-c1ccc2C(=O)c3c([nH]c4cc(ccc34)C#N)-c2c1 Show InChI InChI=1S/C24H21N5O/c1-28(2)8-3-9-29-14-17(13-26-29)16-5-7-18-20(11-16)23-22(24(18)30)19-6-4-15(12-25)10-21(19)27-23/h4-7,10-11,13-14,27H,3,8-9H2,1-2H3	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	14	n/a	n/a	n/a	n/a	n/a	n/a
Harvard Medical School Curated by ChEMBL					Assay Description Inhibition of FLT3 ITD mutant (unknown origin) transduced in mouse Ba/F3 cells assessed as reduction in cell viability after 3 days by cell titer glo...				ACS Med Chem Lett 7: 476-81 (2016) Article DOI: 10.1021/acsmedchemlett.5b00498 BindingDB Entry DOI: 10.7270/Q2HD7XJD
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 (Homo sapiens (Human))	BDBM50177779 (CHEMBL3814908) Show SMILES CN(C)CCCn1cc(cn1)-c1ccc-2c(c1)C(=O)c1c-2[nH]c2cc(ccc12)-c1cn[nH]c1 Show InChI InChI=1S/C26H24N6O/c1-31(2)8-3-9-32-15-19(14-29-32)16-4-6-20-22(10-16)26(33)24-21-7-5-17(18-12-27-28-13-18)11-23(21)30-25(20)24/h4-7,10-15,30H,3,8-9H2,1-2H3,(H,27,28)	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	18	n/a	n/a	n/a	n/a	n/a	n/a
Harvard Medical School Curated by ChEMBL					Assay Description Inhibition of FLT3 ITD mutant (unknown origin) transduced in mouse Ba/F3 cells assessed as reduction in cell viability after 3 days by cell titer glo...				ACS Med Chem Lett 7: 476-81 (2016) Article DOI: 10.1021/acsmedchemlett.5b00498 BindingDB Entry DOI: 10.7270/Q2HD7XJD
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 (Homo sapiens (Human))	BDBM50177721 (CHEMBL3814657) Show SMILES CN(C)CCCn1cc(cn1)-c1ccc2C(=O)c3c([nH]c4cc(ccc34)C#N)-c2c1 Show InChI InChI=1S/C24H21N5O/c1-28(2)8-3-9-29-14-17(13-26-29)16-5-7-18-20(11-16)23-22(24(18)30)19-6-4-15(12-25)10-21(19)27-23/h4-7,10-11,13-14,27H,3,8-9H2,1-2H3	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	26	n/a	n/a	n/a	n/a	n/a	n/a
Harvard Medical School Curated by ChEMBL					Assay Description Inhibition of FLT3 D835Y mutant (unknown origin) transduced in mouse Ba/F3 cells assessed as reduction in cell viability after 3 days by cell titer g...				ACS Med Chem Lett 7: 476-81 (2016) Article DOI: 10.1021/acsmedchemlett.5b00498 BindingDB Entry DOI: 10.7270/Q2HD7XJD
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 (Homo sapiens (Human))	BDBM50177723 (CHEMBL3814446) Show SMILES CN(C)CCn1cc(cn1)-c1ccc2C(=O)c3c([nH]c4cc(ccc34)C#N)-c2c1 Show InChI InChI=1S/C23H19N5O/c1-27(2)7-8-28-13-16(12-25-28)15-4-6-17-19(10-15)22-21(23(17)29)18-5-3-14(11-24)9-20(18)26-22/h3-6,9-10,12-13,26H,7-8H2,1-2H3	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	31	n/a	n/a	n/a	n/a	n/a	n/a
Harvard Medical School Curated by ChEMBL					Assay Description Inhibition of FLT3 D835Y mutant (unknown origin) transduced in mouse Ba/F3 cells assessed as reduction in cell viability after 3 days by cell titer g...				ACS Med Chem Lett 7: 476-81 (2016) Article DOI: 10.1021/acsmedchemlett.5b00498 BindingDB Entry DOI: 10.7270/Q2HD7XJD
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 (Homo sapiens (Human))	BDBM50177723 (CHEMBL3814446) Show SMILES CN(C)CCn1cc(cn1)-c1ccc2C(=O)c3c([nH]c4cc(ccc34)C#N)-c2c1 Show InChI InChI=1S/C23H19N5O/c1-27(2)7-8-28-13-16(12-25-28)15-4-6-17-19(10-15)22-21(23(17)29)18-5-3-14(11-24)9-20(18)26-22/h3-6,9-10,12-13,26H,7-8H2,1-2H3	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	33	n/a	n/a	n/a	n/a	n/a	n/a
Harvard Medical School Curated by ChEMBL					Assay Description Inhibition of FLT3 ITD mutant (unknown origin) transduced in mouse Ba/F3 cells assessed as reduction in cell viability after 3 days by cell titer glo...				ACS Med Chem Lett 7: 476-81 (2016) Article DOI: 10.1021/acsmedchemlett.5b00498 BindingDB Entry DOI: 10.7270/Q2HD7XJD
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 (Homo sapiens (Human))	BDBM50177776 (CHEMBL3814462) Show SMILES O=C1c2ccc(cc2-c2[nH]c3cc(ccc3c12)-c1cn[nH]c1)-c1cn[nH]c1 Show InChI InChI=1S/C21H13N5O/c27-21-15-3-1-11(13-7-22-23-8-13)5-17(15)20-19(21)16-4-2-12(6-18(16)26-20)14-9-24-25-10-14/h1-10,26H,(H,22,23)(H,24,25)	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	34	n/a	n/a	n/a	n/a	n/a	n/a
Harvard Medical School Curated by ChEMBL					Assay Description Inhibition of FLT3 D835Y mutant (unknown origin) transduced in mouse Ba/F3 cells assessed as reduction in cell viability after 3 days by cell titer g...				ACS Med Chem Lett 7: 476-81 (2016) Article DOI: 10.1021/acsmedchemlett.5b00498 BindingDB Entry DOI: 10.7270/Q2HD7XJD
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 (Homo sapiens (Human))	BDBM50177718 (CHEMBL3814734) Show SMILES O=C1c2cc(ccc2-c2[nH]c3cc(ccc3c12)C#N)-c1cn[nH]c1 Show InChI InChI=1S/C19H10N4O/c20-7-10-1-3-14-16(5-10)23-18-13-4-2-11(12-8-21-22-9-12)6-15(13)19(24)17(14)18/h1-6,8-9,23H,(H,21,22)	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	40	n/a	n/a	n/a	n/a	n/a	n/a
Harvard Medical School Curated by ChEMBL					Assay Description Inhibition of FLT3 D835Y mutant (unknown origin) transduced in mouse Ba/F3 cells assessed as reduction in cell viability after 3 days by cell titer g...				ACS Med Chem Lett 7: 476-81 (2016) Article DOI: 10.1021/acsmedchemlett.5b00498 BindingDB Entry DOI: 10.7270/Q2HD7XJD
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 (Homo sapiens (Human))	BDBM50177776 (CHEMBL3814462) Show SMILES O=C1c2ccc(cc2-c2[nH]c3cc(ccc3c12)-c1cn[nH]c1)-c1cn[nH]c1 Show InChI InChI=1S/C21H13N5O/c27-21-15-3-1-11(13-7-22-23-8-13)5-17(15)20-19(21)16-4-2-12(6-18(16)26-20)14-9-24-25-10-14/h1-10,26H,(H,22,23)(H,24,25)	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	55	n/a	n/a	n/a	n/a	n/a	n/a
Harvard Medical School Curated by ChEMBL					Assay Description Inhibition of FLT3 ITD mutant (unknown origin) transduced in mouse Ba/F3 cells assessed as reduction in cell viability after 3 days by cell titer glo...				ACS Med Chem Lett 7: 476-81 (2016) Article DOI: 10.1021/acsmedchemlett.5b00498 BindingDB Entry DOI: 10.7270/Q2HD7XJD
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 (Homo sapiens (Human))	BDBM50177719 (CHEMBL3814055) Show SMILES Cn1cc(cn1)-c1ccc2C(=O)c3c([nH]c4cc(ccc34)C#N)-c2c1 Show InChI InChI=1S/C20H12N4O/c1-24-10-13(9-22-24)12-3-5-14-16(7-12)19-18(20(14)25)15-4-2-11(8-21)6-17(15)23-19/h2-7,9-10,23H,1H3	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	62	n/a	n/a	n/a	n/a	n/a	n/a
Harvard Medical School Curated by ChEMBL					Assay Description Inhibition of FLT3 D835Y mutant (unknown origin) transduced in mouse Ba/F3 cells assessed as reduction in cell viability after 3 days by cell titer g...				ACS Med Chem Lett 7: 476-81 (2016) Article DOI: 10.1021/acsmedchemlett.5b00498 BindingDB Entry DOI: 10.7270/Q2HD7XJD
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 (Homo sapiens (Human))	BDBM50177718 (CHEMBL3814734) Show SMILES O=C1c2cc(ccc2-c2[nH]c3cc(ccc3c12)C#N)-c1cn[nH]c1 Show InChI InChI=1S/C19H10N4O/c20-7-10-1-3-14-16(5-10)23-18-13-4-2-11(12-8-21-22-9-12)6-15(13)19(24)17(14)18/h1-6,8-9,23H,(H,21,22)	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	74	n/a	n/a	n/a	n/a	n/a	n/a
Harvard Medical School Curated by ChEMBL					Assay Description Inhibition of FLT3 ITD mutant (unknown origin) transduced in mouse Ba/F3 cells assessed as reduction in cell viability after 3 days by cell titer glo...				ACS Med Chem Lett 7: 476-81 (2016) Article DOI: 10.1021/acsmedchemlett.5b00498 BindingDB Entry DOI: 10.7270/Q2HD7XJD
					More data for this Ligand-Target Pair
Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform (Homo sapiens (Human))	BDBM50177715 (CHEMBL3815054) Show SMILES CN(C)CCCn1cc(cn1)-c1ccc2C(=O)c3c([nH]c4cc(ccc34)-c3cn[nH]c3)-c2c1 Show InChI InChI=1S/C26H24N6O/c1-31(2)8-3-9-32-15-19(14-29-32)16-4-6-20-22(10-16)25-24(26(20)33)21-7-5-17(11-23(21)30-25)18-12-27-28-13-18/h4-7,10-15,30H,3,8-9H2,1-2H3,(H,27,28)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	78	n/a	n/a	n/a	n/a	n/a	n/a
Harvard Medical School Curated by ChEMBL					Assay Description Inhibition of PHKGI (unknown origin) by kinomescan analysis				ACS Med Chem Lett 7: 476-81 (2016) Article DOI: 10.1021/acsmedchemlett.5b00498 BindingDB Entry DOI: 10.7270/Q2HD7XJD
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 (Homo sapiens (Human))	BDBM50177720 (CHEMBL3814090) Show SMILES Cn1cc(cn1)-c1ccc-2c(c1)C(=O)c1c-2[nH]c2cc(ccc12)C#N Show InChI InChI=1S/C20H12N4O/c1-24-10-13(9-22-24)12-3-5-14-16(7-12)20(25)18-15-4-2-11(8-21)6-17(15)23-19(14)18/h2-7,9-10,23H,1H3	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	83	n/a	n/a	n/a	n/a	n/a	n/a
Harvard Medical School Curated by ChEMBL					Assay Description Inhibition of FLT3 D835Y mutant (unknown origin) transduced in mouse Ba/F3 cells assessed as reduction in cell viability after 3 days by cell titer g...				ACS Med Chem Lett 7: 476-81 (2016) Article DOI: 10.1021/acsmedchemlett.5b00498 BindingDB Entry DOI: 10.7270/Q2HD7XJD
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 (Homo sapiens (Human))	BDBM50300690 (1-(5-Tert-Butyl-1,2-Oxazol-3-Yl)-3-(4-{7-[2-(Morph...) Show SMILES CC(C)(C)c1cc(NC(=O)Nc2ccc(cc2)-c2cn3c(n2)sc2cc(OCCN4CCOCC4)ccc32)no1 Show InChI InChI=1S/C29H32N6O4S/c1-29(2,3)25-17-26(33-39-25)32-27(36)30-20-6-4-19(5-7-20)22-18-35-23-9-8-21(16-24(23)40-28(35)31-22)38-15-12-34-10-13-37-14-11-34/h4-9,16-18H,10-15H2,1-3H3,(H2,30,32,33,36)	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	93	n/a	n/a	n/a	n/a	n/a	n/a
Harvard Medical School Curated by ChEMBL					Assay Description Competitive inhibition of FLT3 D835Y mutant (unknown origin) in presence of ATP				ACS Med Chem Lett 7: 476-81 (2016) Article DOI: 10.1021/acsmedchemlett.5b00498 BindingDB Entry DOI: 10.7270/Q2HD7XJD
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 (Homo sapiens (Human))	BDBM50177724 (CHEMBL3814032) Show SMILES CN(C)CCn1cc(cn1)-c1ccc-2c(c1)C(=O)c1c-2[nH]c2cc(ccc12)C#N Show InChI InChI=1S/C23H19N5O/c1-27(2)7-8-28-13-16(12-25-28)15-4-6-17-19(10-15)23(29)21-18-5-3-14(11-24)9-20(18)26-22(17)21/h3-6,9-10,12-13,26H,7-8H2,1-2H3	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	96	n/a	n/a	n/a	n/a	n/a	n/a
Harvard Medical School Curated by ChEMBL					Assay Description Inhibition of FLT3 D835Y mutant (unknown origin) transduced in mouse Ba/F3 cells assessed as reduction in cell viability after 3 days by cell titer g...				ACS Med Chem Lett 7: 476-81 (2016) Article DOI: 10.1021/acsmedchemlett.5b00498 BindingDB Entry DOI: 10.7270/Q2HD7XJD
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 (Homo sapiens (Human))	BDBM50177717 (CHEMBL3814207) Show SMILES O=C1c2ccc(cc2-c2[nH]c3cc(ccc3c12)C#N)-c1cn[nH]c1 Show InChI InChI=1S/C19H10N4O/c20-7-10-1-3-14-16(5-10)23-18-15-6-11(12-8-21-22-9-12)2-4-13(15)19(24)17(14)18/h1-6,8-9,23H,(H,21,22)	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	96	n/a	n/a	n/a	n/a	n/a	n/a
Harvard Medical School Curated by ChEMBL					Assay Description Inhibition of FLT3 D835Y mutant (unknown origin) transduced in mouse Ba/F3 cells assessed as reduction in cell viability after 3 days by cell titer g...				ACS Med Chem Lett 7: 476-81 (2016) Article DOI: 10.1021/acsmedchemlett.5b00498 BindingDB Entry DOI: 10.7270/Q2HD7XJD
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 (Homo sapiens (Human))	BDBM50177720 (CHEMBL3814090) Show SMILES Cn1cc(cn1)-c1ccc-2c(c1)C(=O)c1c-2[nH]c2cc(ccc12)C#N Show InChI InChI=1S/C20H12N4O/c1-24-10-13(9-22-24)12-3-5-14-16(7-12)20(25)18-15-4-2-11(8-21)6-17(15)23-19(14)18/h2-7,9-10,23H,1H3	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	97	n/a	n/a	n/a	n/a	n/a	n/a
Harvard Medical School Curated by ChEMBL					Assay Description Inhibition of FLT3 ITD mutant (unknown origin) transduced in mouse Ba/F3 cells assessed as reduction in cell viability after 3 days by cell titer glo...				ACS Med Chem Lett 7: 476-81 (2016) Article DOI: 10.1021/acsmedchemlett.5b00498 BindingDB Entry DOI: 10.7270/Q2HD7XJD
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 (Homo sapiens (Human))	BDBM50177725 (CHEMBL3815134) Show SMILES CNC(=O)Cn1cc(cn1)-c1ccc2C(=O)c3c([nH]c4cc(ccc34)C#N)-c2c1 Show InChI InChI=1S/C22H15N5O2/c1-24-19(28)11-27-10-14(9-25-27)13-3-5-15-17(7-13)21-20(22(15)29)16-4-2-12(8-23)6-18(16)26-21/h2-7,9-10,26H,11H2,1H3,(H,24,28)	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	114	n/a	n/a	n/a	n/a	n/a	n/a
Harvard Medical School Curated by ChEMBL					Assay Description Inhibition of FLT3 D835Y mutant (unknown origin) transduced in mouse Ba/F3 cells assessed as reduction in cell viability after 3 days by cell titer g...				ACS Med Chem Lett 7: 476-81 (2016) Article DOI: 10.1021/acsmedchemlett.5b00498 BindingDB Entry DOI: 10.7270/Q2HD7XJD
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 (Homo sapiens (Human))	BDBM50177725 (CHEMBL3815134) Show SMILES CNC(=O)Cn1cc(cn1)-c1ccc2C(=O)c3c([nH]c4cc(ccc34)C#N)-c2c1 Show InChI InChI=1S/C22H15N5O2/c1-24-19(28)11-27-10-14(9-25-27)13-3-5-15-17(7-13)21-20(22(15)29)16-4-2-12(8-23)6-18(16)26-21/h2-7,9-10,26H,11H2,1H3,(H,24,28)	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	124	n/a	n/a	n/a	n/a	n/a	n/a
Harvard Medical School Curated by ChEMBL					Assay Description Inhibition of FLT3 ITD mutant (unknown origin) transduced in mouse Ba/F3 cells assessed as reduction in cell viability after 3 days by cell titer glo...				ACS Med Chem Lett 7: 476-81 (2016) Article DOI: 10.1021/acsmedchemlett.5b00498 BindingDB Entry DOI: 10.7270/Q2HD7XJD
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 (Homo sapiens (Human))	BDBM50177775 (CHEMBL3814654) Show SMILES O=C1c2cc(ccc2-c2[nH]c3cc(ccc3c12)-c1cn[nH]c1)-c1cn[nH]c1 Show InChI InChI=1S/C21H13N5O/c27-21-17-5-11(13-7-22-23-8-13)1-3-15(17)20-19(21)16-4-2-12(6-18(16)26-20)14-9-24-25-10-14/h1-10,26H,(H,22,23)(H,24,25)	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	126	n/a	n/a	n/a	n/a	n/a	n/a
Harvard Medical School Curated by ChEMBL					Assay Description Inhibition of FLT3 D835Y mutant (unknown origin) transduced in mouse Ba/F3 cells assessed as reduction in cell viability after 3 days by cell titer g...				ACS Med Chem Lett 7: 476-81 (2016) Article DOI: 10.1021/acsmedchemlett.5b00498 BindingDB Entry DOI: 10.7270/Q2HD7XJD
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 (Homo sapiens (Human))	BDBM50177717 (CHEMBL3814207) Show SMILES O=C1c2ccc(cc2-c2[nH]c3cc(ccc3c12)C#N)-c1cn[nH]c1 Show InChI InChI=1S/C19H10N4O/c20-7-10-1-3-14-16(5-10)23-18-15-6-11(12-8-21-22-9-12)2-4-13(15)19(24)17(14)18/h1-6,8-9,23H,(H,21,22)	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	128	n/a	n/a	n/a	n/a	n/a	n/a
Harvard Medical School Curated by ChEMBL					Assay Description Inhibition of FLT3 ITD mutant (unknown origin) transduced in mouse Ba/F3 cells assessed as reduction in cell viability after 3 days by cell titer glo...				ACS Med Chem Lett 7: 476-81 (2016) Article DOI: 10.1021/acsmedchemlett.5b00498 BindingDB Entry DOI: 10.7270/Q2HD7XJD
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 (Homo sapiens (Human))	BDBM50177716 (CHEMBL3813873 | US11679110, Compound Pexidartinib ...) Show SMILES FC(F)(F)c1ccc(CNc2ccc(Cc3c[nH]c4ncc(Cl)cc34)cn2)cn1 Show InChI InChI=1S/C20H15ClF3N5/c21-15-6-16-14(10-28-19(16)29-11-15)5-12-2-4-18(26-7-12)27-9-13-1-3-17(25-8-13)20(22,23)24/h1-4,6-8,10-11H,5,9H2,(H,26,27)(H,28,29)	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	130	n/a	n/a	n/a	n/a	n/a	n/a
Harvard Medical School Curated by ChEMBL					Assay Description Competitive inhibition of FLT3 ITD mutant (unknown origin) in presence of ATP				ACS Med Chem Lett 7: 476-81 (2016) Article DOI: 10.1021/acsmedchemlett.5b00498 BindingDB Entry DOI: 10.7270/Q2HD7XJD
					More data for this Ligand-Target Pair
Dual specificity protein kinase CLK4 (Homo sapiens (Human))	BDBM50177715 (CHEMBL3815054) Show SMILES CN(C)CCCn1cc(cn1)-c1ccc2C(=O)c3c([nH]c4cc(ccc34)-c3cn[nH]c3)-c2c1 Show InChI InChI=1S/C26H24N6O/c1-31(2)8-3-9-32-15-19(14-29-32)16-4-6-20-22(10-16)25-24(26(20)33)21-7-5-17(11-23(21)30-25)18-12-27-28-13-18/h4-7,10-15,30H,3,8-9H2,1-2H3,(H,27,28)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	142	n/a	n/a	n/a	n/a	n/a	n/a
Harvard Medical School Curated by ChEMBL					Assay Description Inhibition of CLK4 (unknown origin) by kinomescan analysis				ACS Med Chem Lett 7: 476-81 (2016) Article DOI: 10.1021/acsmedchemlett.5b00498 BindingDB Entry DOI: 10.7270/Q2HD7XJD
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 (Homo sapiens (Human))	BDBM50177724 (CHEMBL3814032) Show SMILES CN(C)CCn1cc(cn1)-c1ccc-2c(c1)C(=O)c1c-2[nH]c2cc(ccc12)C#N Show InChI InChI=1S/C23H19N5O/c1-27(2)7-8-28-13-16(12-25-28)15-4-6-17-19(10-15)23(29)21-18-5-3-14(11-24)9-20(18)26-22(17)21/h3-6,9-10,12-13,26H,7-8H2,1-2H3	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	143	n/a	n/a	n/a	n/a	n/a	n/a
Harvard Medical School Curated by ChEMBL					Assay Description Inhibition of FLT3 ITD mutant (unknown origin) transduced in mouse Ba/F3 cells assessed as reduction in cell viability after 3 days by cell titer glo...				ACS Med Chem Lett 7: 476-81 (2016) Article DOI: 10.1021/acsmedchemlett.5b00498 BindingDB Entry DOI: 10.7270/Q2HD7XJD
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 (Homo sapiens (Human))	BDBM50177719 (CHEMBL3814055) Show SMILES Cn1cc(cn1)-c1ccc2C(=O)c3c([nH]c4cc(ccc34)C#N)-c2c1 Show InChI InChI=1S/C20H12N4O/c1-24-10-13(9-22-24)12-3-5-14-16(7-12)19-18(20(14)25)15-4-2-11(8-21)6-17(15)23-19/h2-7,9-10,23H,1H3	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	146	n/a	n/a	n/a	n/a	n/a	n/a
Harvard Medical School Curated by ChEMBL					Assay Description Inhibition of FLT3 ITD mutant (unknown origin) transduced in mouse Ba/F3 cells assessed as reduction in cell viability after 3 days by cell titer glo...				ACS Med Chem Lett 7: 476-81 (2016) Article DOI: 10.1021/acsmedchemlett.5b00498 BindingDB Entry DOI: 10.7270/Q2HD7XJD
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 (Homo sapiens (Human))	BDBM50177775 (CHEMBL3814654) Show SMILES O=C1c2cc(ccc2-c2[nH]c3cc(ccc3c12)-c1cn[nH]c1)-c1cn[nH]c1 Show InChI InChI=1S/C21H13N5O/c27-21-17-5-11(13-7-22-23-8-13)1-3-15(17)20-19(21)16-4-2-12(6-18(16)26-20)14-9-24-25-10-14/h1-10,26H,(H,22,23)(H,24,25)	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	182	n/a	n/a	n/a	n/a	n/a	n/a
Harvard Medical School Curated by ChEMBL					Assay Description Inhibition of FLT3 ITD mutant (unknown origin) transduced in mouse Ba/F3 cells assessed as reduction in cell viability after 3 days by cell titer glo...				ACS Med Chem Lett 7: 476-81 (2016) Article DOI: 10.1021/acsmedchemlett.5b00498 BindingDB Entry DOI: 10.7270/Q2HD7XJD
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 (Homo sapiens (Human))	BDBM50177726 (CHEMBL3813745) Show SMILES CNC(=O)Cn1cc(cn1)-c1ccc-2c(c1)C(=O)c1c-2[nH]c2cc(ccc12)C#N Show InChI InChI=1S/C22H15N5O2/c1-24-19(28)11-27-10-14(9-25-27)13-3-5-15-17(7-13)22(29)20-16-4-2-12(8-23)6-18(16)26-21(15)20/h2-7,9-10,26H,11H2,1H3,(H,24,28)	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	280	n/a	n/a	n/a	n/a	n/a	n/a
Harvard Medical School Curated by ChEMBL					Assay Description Inhibition of FLT3 ITD mutant (unknown origin) transduced in mouse Ba/F3 cells assessed as reduction in cell viability after 3 days by cell titer glo...				ACS Med Chem Lett 7: 476-81 (2016) Article DOI: 10.1021/acsmedchemlett.5b00498 BindingDB Entry DOI: 10.7270/Q2HD7XJD
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 (Homo sapiens (Human))	BDBM50177773 (CHEMBL3813913) Show SMILES O=C1c2ccc(cc2-c2[nH]c3cc(ccc3c12)C#N)-c1cccnc1 Show InChI InChI=1S/C21H11N3O/c22-10-12-3-5-16-18(8-12)24-20-17-9-13(14-2-1-7-23-11-14)4-6-15(17)21(25)19(16)20/h1-9,11,24H	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	356	n/a	n/a	n/a	n/a	n/a	n/a
Harvard Medical School Curated by ChEMBL					Assay Description Inhibition of FLT3 ITD mutant (unknown origin) transduced in mouse Ba/F3 cells assessed as reduction in cell viability after 3 days by cell titer glo...				ACS Med Chem Lett 7: 476-81 (2016) Article DOI: 10.1021/acsmedchemlett.5b00498 BindingDB Entry DOI: 10.7270/Q2HD7XJD
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 (Homo sapiens (Human))	BDBM50177726 (CHEMBL3813745) Show SMILES CNC(=O)Cn1cc(cn1)-c1ccc-2c(c1)C(=O)c1c-2[nH]c2cc(ccc12)C#N Show InChI InChI=1S/C22H15N5O2/c1-24-19(28)11-27-10-14(9-25-27)13-3-5-15-17(7-13)22(29)20-16-4-2-12(8-23)6-18(16)26-21(15)20/h2-7,9-10,26H,11H2,1H3,(H,24,28)	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	365	n/a	n/a	n/a	n/a	n/a	n/a
Harvard Medical School Curated by ChEMBL					Assay Description Inhibition of FLT3 D835Y mutant (unknown origin) transduced in mouse Ba/F3 cells assessed as reduction in cell viability after 3 days by cell titer g...				ACS Med Chem Lett 7: 476-81 (2016) Article DOI: 10.1021/acsmedchemlett.5b00498 BindingDB Entry DOI: 10.7270/Q2HD7XJD
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 (Homo sapiens (Human))	BDBM50177722 (CHEMBL3814702) Show SMILES CN(C)CCCn1cc(cn1)-c1ccc-2c(c1)C(=O)c1c-2[nH]c2cc(ccc12)C#N Show InChI InChI=1S/C24H21N5O/c1-28(2)8-3-9-29-14-17(13-26-29)16-5-7-18-20(11-16)24(30)22-19-6-4-15(12-25)10-21(19)27-23(18)22/h4-7,10-11,13-14,27H,3,8-9H2,1-2H3	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	424	n/a	n/a	n/a	n/a	n/a	n/a
Harvard Medical School Curated by ChEMBL					Assay Description Inhibition of FLT3 ITD mutant (unknown origin) transduced in mouse Ba/F3 cells assessed as reduction in cell viability after 3 days by cell titer glo...				ACS Med Chem Lett 7: 476-81 (2016) Article DOI: 10.1021/acsmedchemlett.5b00498 BindingDB Entry DOI: 10.7270/Q2HD7XJD
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 (Homo sapiens (Human))	BDBM50177722 (CHEMBL3814702) Show SMILES CN(C)CCCn1cc(cn1)-c1ccc-2c(c1)C(=O)c1c-2[nH]c2cc(ccc12)C#N Show InChI InChI=1S/C24H21N5O/c1-28(2)8-3-9-29-14-17(13-26-29)16-5-7-18-20(11-16)24(30)22-19-6-4-15(12-25)10-21(19)27-23(18)22/h4-7,10-11,13-14,27H,3,8-9H2,1-2H3	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	430	n/a	n/a	n/a	n/a	n/a	n/a
Harvard Medical School Curated by ChEMBL					Assay Description Inhibition of FLT3 D835Y mutant (unknown origin) transduced in mouse Ba/F3 cells assessed as reduction in cell viability after 3 days by cell titer g...				ACS Med Chem Lett 7: 476-81 (2016) Article DOI: 10.1021/acsmedchemlett.5b00498 BindingDB Entry DOI: 10.7270/Q2HD7XJD
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 (Homo sapiens (Human))	BDBM50177773 (CHEMBL3813913) Show SMILES O=C1c2ccc(cc2-c2[nH]c3cc(ccc3c12)C#N)-c1cccnc1 Show InChI InChI=1S/C21H11N3O/c22-10-12-3-5-16-18(8-12)24-20-17-9-13(14-2-1-7-23-11-14)4-6-15(17)21(25)19(16)20/h1-9,11,24H	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	502	n/a	n/a	n/a	n/a	n/a	n/a
Harvard Medical School Curated by ChEMBL					Assay Description Inhibition of FLT3 D835Y mutant (unknown origin) transduced in mouse Ba/F3 cells assessed as reduction in cell viability after 3 days by cell titer g...				ACS Med Chem Lett 7: 476-81 (2016) Article DOI: 10.1021/acsmedchemlett.5b00498 BindingDB Entry DOI: 10.7270/Q2HD7XJD
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 (Homo sapiens (Human))	BDBM50177772 (CHEMBL3814677) Show SMILES O=C1c2cc(ccc2-c2[nH]c3cc(ccc3c12)C#N)-c1ccncc1 Show InChI InChI=1S/C21H11N3O/c22-11-12-1-3-16-18(9-12)24-20-15-4-2-14(13-5-7-23-8-6-13)10-17(15)21(25)19(16)20/h1-10,24H	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	692	n/a	n/a	n/a	n/a	n/a	n/a
Harvard Medical School Curated by ChEMBL					Assay Description Inhibition of FLT3 D835Y mutant (unknown origin) transduced in mouse Ba/F3 cells assessed as reduction in cell viability after 3 days by cell titer g...				ACS Med Chem Lett 7: 476-81 (2016) Article DOI: 10.1021/acsmedchemlett.5b00498 BindingDB Entry DOI: 10.7270/Q2HD7XJD
					More data for this Ligand-Target Pair
Rho-associated protein kinase 2 (Homo sapiens (Human))	BDBM50177715 (CHEMBL3815054) Show SMILES CN(C)CCCn1cc(cn1)-c1ccc2C(=O)c3c([nH]c4cc(ccc34)-c3cn[nH]c3)-c2c1 Show InChI InChI=1S/C26H24N6O/c1-31(2)8-3-9-32-15-19(14-29-32)16-4-6-20-22(10-16)25-24(26(20)33)21-7-5-17(11-23(21)30-25)18-12-27-28-13-18/h4-7,10-15,30H,3,8-9H2,1-2H3,(H,27,28)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	936	n/a	n/a	n/a	n/a	n/a	n/a
Harvard Medical School Curated by ChEMBL					Assay Description Inhibition of ROCK2 (unknown origin) by kinomescan analysis				ACS Med Chem Lett 7: 476-81 (2016) Article DOI: 10.1021/acsmedchemlett.5b00498 BindingDB Entry DOI: 10.7270/Q2HD7XJD
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 (Homo sapiens (Human))	BDBM50177772 (CHEMBL3814677) Show SMILES O=C1c2cc(ccc2-c2[nH]c3cc(ccc3c12)C#N)-c1ccncc1 Show InChI InChI=1S/C21H11N3O/c22-11-12-1-3-16-18(9-12)24-20-15-4-2-14(13-5-7-23-8-6-13)10-17(15)21(25)19(16)20/h1-10,24H	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	937	n/a	n/a	n/a	n/a	n/a	n/a
Harvard Medical School Curated by ChEMBL					Assay Description Inhibition of FLT3 ITD mutant (unknown origin) transduced in mouse Ba/F3 cells assessed as reduction in cell viability after 3 days by cell titer glo...				ACS Med Chem Lett 7: 476-81 (2016) Article DOI: 10.1021/acsmedchemlett.5b00498 BindingDB Entry DOI: 10.7270/Q2HD7XJD
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 (Homo sapiens (Human))	BDBM50177774 (CHEMBL3814749) Show SMILES O=C1c2cc(ccc2-c2[nH]c3cc(ccc3c12)C#N)-c1cccnc1 Show InChI InChI=1S/C21H11N3O/c22-10-12-3-5-16-18(8-12)24-20-15-6-4-13(14-2-1-7-23-11-14)9-17(15)21(25)19(16)20/h1-9,11,24H	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	946	n/a	n/a	n/a	n/a	n/a	n/a
Harvard Medical School Curated by ChEMBL					Assay Description Inhibition of FLT3 D835Y mutant (unknown origin) transduced in mouse Ba/F3 cells assessed as reduction in cell viability after 3 days by cell titer g...				ACS Med Chem Lett 7: 476-81 (2016) Article DOI: 10.1021/acsmedchemlett.5b00498 BindingDB Entry DOI: 10.7270/Q2HD7XJD
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 (Homo sapiens (Human))	BDBM50177777 (CHEMBL3813943) Show SMILES Cn1cc(cn1)-c1ccc-2c(c1)C(=O)c1c-2[nH]c2cc(ccc12)-c1cn[nH]c1 Show InChI InChI=1S/C22H15N5O/c1-27-11-15(10-25-27)12-2-4-16-18(6-12)22(28)20-17-5-3-13(14-8-23-24-9-14)7-19(17)26-21(16)20/h2-11,26H,1H3,(H,23,24)	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.53E+3	n/a	n/a	n/a	n/a	n/a	n/a
Harvard Medical School Curated by ChEMBL					Assay Description Inhibition of FLT3 D835Y mutant (unknown origin) transduced in mouse Ba/F3 cells assessed as reduction in cell viability after 3 days by cell titer g...				ACS Med Chem Lett 7: 476-81 (2016) Article DOI: 10.1021/acsmedchemlett.5b00498 BindingDB Entry DOI: 10.7270/Q2HD7XJD
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 (Homo sapiens (Human))	BDBM50177770 (CHEMBL3815101) Show SMILES O=C1c2ccc(cc2-c2[nH]c3cc(ccc3c12)C#N)-c1ccncc1 Show InChI InChI=1S/C21H11N3O/c22-11-12-1-3-16-18(9-12)24-20-17-10-14(13-5-7-23-8-6-13)2-4-15(17)21(25)19(16)20/h1-10,24H	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.58E+3	n/a	n/a	n/a	n/a	n/a	n/a
Harvard Medical School Curated by ChEMBL					Assay Description Inhibition of FLT3 ITD mutant (unknown origin) transduced in mouse Ba/F3 cells assessed as reduction in cell viability after 3 days by cell titer glo...				ACS Med Chem Lett 7: 476-81 (2016) Article DOI: 10.1021/acsmedchemlett.5b00498 BindingDB Entry DOI: 10.7270/Q2HD7XJD
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 (Homo sapiens (Human))	BDBM50177774 (CHEMBL3814749) Show SMILES O=C1c2cc(ccc2-c2[nH]c3cc(ccc3c12)C#N)-c1cccnc1 Show InChI InChI=1S/C21H11N3O/c22-10-12-3-5-16-18(8-12)24-20-15-6-4-13(14-2-1-7-23-11-14)9-17(15)21(25)19(16)20/h1-9,11,24H	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.24E+3	n/a	n/a	n/a	n/a	n/a	n/a
Harvard Medical School Curated by ChEMBL					Assay Description Inhibition of FLT3 ITD mutant (unknown origin) transduced in mouse Ba/F3 cells assessed as reduction in cell viability after 3 days by cell titer glo...				ACS Med Chem Lett 7: 476-81 (2016) Article DOI: 10.1021/acsmedchemlett.5b00498 BindingDB Entry DOI: 10.7270/Q2HD7XJD
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 (Homo sapiens (Human))	BDBM50177777 (CHEMBL3813943) Show SMILES Cn1cc(cn1)-c1ccc-2c(c1)C(=O)c1c-2[nH]c2cc(ccc12)-c1cn[nH]c1 Show InChI InChI=1S/C22H15N5O/c1-27-11-15(10-25-27)12-2-4-16-18(6-12)22(28)20-17-5-3-13(14-8-23-24-9-14)7-19(17)26-21(16)20/h2-11,26H,1H3,(H,23,24)	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.49E+3	n/a	n/a	n/a	n/a	n/a	n/a
Harvard Medical School Curated by ChEMBL					Assay Description Inhibition of FLT3 ITD mutant (unknown origin) transduced in mouse Ba/F3 cells assessed as reduction in cell viability after 3 days by cell titer glo...				ACS Med Chem Lett 7: 476-81 (2016) Article DOI: 10.1021/acsmedchemlett.5b00498 BindingDB Entry DOI: 10.7270/Q2HD7XJD
					More data for this Ligand-Target Pair

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