Found 88 hits with Last Name = 'suo' and Initial = 'j' Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
cGMP-specific 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50525064
(CHEMBL4455533)Show SMILES CCCOc1ccc(NC(=O)[C@@H]2CCCN2C(C)=O)cc1-c1nc(CC)c(CC)c(=O)[nH]1 |r| Show InChI InChI=1S/C24H32N4O4/c1-5-13-32-21-11-10-16(25-24(31)20-9-8-12-28(20)15(4)29)14-18(21)22-26-19(7-3)17(6-2)23(30)27-22/h10-11,14,20H,5-9,12-13H2,1-4H3,(H,25,31)(H,26,27,30)/t20-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 0.540 | n/a | n/a | n/a | n/a | n/a | n/a |
Chinese Academy of Sciences
Curated by ChEMBL
| Assay Description
Inhibition of N-terminal GST-tagged human PDE5A1 expressed in baculovirus infected sf9 cells using [3H]cGMP as substrate measured after 30 mins by sc... |
J Med Chem 62: 4979-4990 (2019)
Article DOI: 10.1021/acs.jmedchem.9b00123
BindingDB Entry DOI: 10.7270/Q2T72MWB |
More data for this
Ligand-Target Pair | |
cGMP-specific 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50525060
(CHEMBL4462192)Show SMILES CCCOc1ccc(NC(=O)CN2CCN(C)CC2)cc1-c1nc(CC)c(CC)c(=O)[nH]1 Show InChI InChI=1S/C24H35N5O3/c1-5-14-32-21-9-8-17(25-22(30)16-29-12-10-28(4)11-13-29)15-19(21)23-26-20(7-3)18(6-2)24(31)27-23/h8-9,15H,5-7,10-14,16H2,1-4H3,(H,25,30)(H,26,27,31) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
MCE
PC cid
PC sid
PDB
UniChem
| PDB
Article
PubMed
| n/a | n/a | 0.620 | n/a | n/a | n/a | n/a | n/a | n/a |
Chinese Academy of Sciences
Curated by ChEMBL
| Assay Description
Inhibition of N-terminal GST-tagged human PDE5A1 expressed in baculovirus infected sf9 cells using [3H]cGMP as substrate measured after 30 mins by sc... |
J Med Chem 62: 4979-4990 (2019)
Article DOI: 10.1021/acs.jmedchem.9b00123
BindingDB Entry DOI: 10.7270/Q2T72MWB |
More data for this
Ligand-Target Pair | 
3D Structure (crystal) |
cGMP-specific 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50525071
(CHEMBL4474634)Show SMILES CCCOc1ccc(NC(=O)C2CCN(C)CC2)cc1-c1nc(CC)c(CC)c(=O)[nH]1 Show InChI InChI=1S/C24H34N4O3/c1-5-14-31-21-9-8-17(25-23(29)16-10-12-28(4)13-11-16)15-19(21)22-26-20(7-3)18(6-2)24(30)27-22/h8-9,15-16H,5-7,10-14H2,1-4H3,(H,25,29)(H,26,27,30) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 0.790 | n/a | n/a | n/a | n/a | n/a | n/a |
Chinese Academy of Sciences
Curated by ChEMBL
| Assay Description
Inhibition of N-terminal GST-tagged human PDE5A1 expressed in baculovirus infected sf9 cells using [3H]cGMP as substrate measured after 30 mins by sc... |
J Med Chem 62: 4979-4990 (2019)
Article DOI: 10.1021/acs.jmedchem.9b00123
BindingDB Entry DOI: 10.7270/Q2T72MWB |
More data for this
Ligand-Target Pair | |
cGMP-specific 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50525067
(CHEMBL4444940)Show SMILES CCCOc1ccc(NC(=O)C(N)=O)cc1-c1nc(CC)c(CC)c(=O)[nH]1 Show InChI InChI=1S/C19H24N4O4/c1-4-9-27-15-8-7-11(21-19(26)16(20)24)10-13(15)17-22-14(6-3)12(5-2)18(25)23-17/h7-8,10H,4-6,9H2,1-3H3,(H2,20,24)(H,21,26)(H,22,23,25) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 0.830 | n/a | n/a | n/a | n/a | n/a | n/a |
Chinese Academy of Sciences
Curated by ChEMBL
| Assay Description
Inhibition of N-terminal GST-tagged human PDE5A1 expressed in baculovirus infected sf9 cells using [3H]cGMP as substrate measured after 30 mins by sc... |
J Med Chem 62: 4979-4990 (2019)
Article DOI: 10.1021/acs.jmedchem.9b00123
BindingDB Entry DOI: 10.7270/Q2T72MWB |
More data for this
Ligand-Target Pair | |
cGMP-specific 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50525069
(CHEMBL4467125)Show SMILES CCCOc1ccc(NC(=O)CCCNC(C)=O)cc1-c1nc(CC)c(CC)c(=O)[nH]1 Show InChI InChI=1S/C23H32N4O4/c1-5-13-31-20-11-10-16(25-21(29)9-8-12-24-15(4)28)14-18(20)22-26-19(7-3)17(6-2)23(30)27-22/h10-11,14H,5-9,12-13H2,1-4H3,(H,24,28)(H,25,29)(H,26,27,30) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 0.920 | n/a | n/a | n/a | n/a | n/a | n/a |
Chinese Academy of Sciences
Curated by ChEMBL
| Assay Description
Inhibition of N-terminal GST-tagged human PDE5A1 expressed in baculovirus infected sf9 cells using [3H]cGMP as substrate measured after 30 mins by sc... |
J Med Chem 62: 4979-4990 (2019)
Article DOI: 10.1021/acs.jmedchem.9b00123
BindingDB Entry DOI: 10.7270/Q2T72MWB |
More data for this
Ligand-Target Pair | |
cGMP-specific 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50525061
(CHEMBL4468620)Show SMILES CCCOc1ccc(cc1-c1nc(CC)c(CC)c(=O)[nH]1)S(=O)(=O)N(CCO)CCN1CCOCC1 Show InChI InChI=1S/C25H38N4O6S/c1-4-15-35-23-8-7-19(18-21(23)24-26-22(6-3)20(5-2)25(31)27-24)36(32,33)29(11-14-30)10-9-28-12-16-34-17-13-28/h7-8,18,30H,4-6,9-17H2,1-3H3,(H,26,27,31) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
Chinese Academy of Sciences
Curated by ChEMBL
| Assay Description
Inhibition of N-terminal GST-tagged human PDE5A1 expressed in baculovirus infected sf9 cells using [3H]cGMP as substrate measured after 30 mins by sc... |
J Med Chem 62: 4979-4990 (2019)
Article DOI: 10.1021/acs.jmedchem.9b00123
BindingDB Entry DOI: 10.7270/Q2T72MWB |
More data for this
Ligand-Target Pair | |
cGMP-specific 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50525058
(CHEMBL4559488)Show SMILES CCCOc1ccc(NC(=O)CC)cc1-c1nc(CC)c(CC)c(=O)[nH]1 Show InChI InChI=1S/C20H27N3O3/c1-5-11-26-17-10-9-13(21-18(24)8-4)12-15(17)19-22-16(7-3)14(6-2)20(25)23-19/h9-10,12H,5-8,11H2,1-4H3,(H,21,24)(H,22,23,25) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 1.20 | n/a | n/a | n/a | n/a | n/a | n/a |
Chinese Academy of Sciences
Curated by ChEMBL
| Assay Description
Inhibition of N-terminal GST-tagged human PDE5A1 expressed in baculovirus infected sf9 cells using [3H]cGMP as substrate measured after 30 mins by sc... |
J Med Chem 62: 4979-4990 (2019)
Article DOI: 10.1021/acs.jmedchem.9b00123
BindingDB Entry DOI: 10.7270/Q2T72MWB |
More data for this
Ligand-Target Pair | |
cGMP-specific 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50525068
(CHEMBL4483406)Show SMILES CCCOc1ccc(NS(C)(=O)=O)cc1-c1nc(CC)c(CC)c(=O)[nH]1 Show InChI InChI=1S/C18H25N3O4S/c1-5-10-25-16-9-8-12(21-26(4,23)24)11-14(16)17-19-15(7-3)13(6-2)18(22)20-17/h8-9,11,21H,5-7,10H2,1-4H3,(H,19,20,22) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 1.20 | n/a | n/a | n/a | n/a | n/a | n/a |
Chinese Academy of Sciences
Curated by ChEMBL
| Assay Description
Inhibition of N-terminal GST-tagged human PDE5A1 expressed in baculovirus infected sf9 cells using [3H]cGMP as substrate measured after 30 mins by sc... |
J Med Chem 62: 4979-4990 (2019)
Article DOI: 10.1021/acs.jmedchem.9b00123
BindingDB Entry DOI: 10.7270/Q2T72MWB |
More data for this
Ligand-Target Pair | |
cGMP-specific 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50525065
(CHEMBL4572238)Show SMILES CCCOc1ccc(NC(=O)CN2CCCCC2)cc1-c1nc(CC)c(CC)c(=O)[nH]1 Show InChI InChI=1S/C24H34N4O3/c1-4-14-31-21-11-10-17(25-22(29)16-28-12-8-7-9-13-28)15-19(21)23-26-20(6-3)18(5-2)24(30)27-23/h10-11,15H,4-9,12-14,16H2,1-3H3,(H,25,29)(H,26,27,30) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 1.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Chinese Academy of Sciences
Curated by ChEMBL
| Assay Description
Inhibition of N-terminal GST-tagged human PDE5A1 expressed in baculovirus infected sf9 cells using [3H]cGMP as substrate measured after 30 mins by sc... |
J Med Chem 62: 4979-4990 (2019)
Article DOI: 10.1021/acs.jmedchem.9b00123
BindingDB Entry DOI: 10.7270/Q2T72MWB |
More data for this
Ligand-Target Pair | |
cGMP-specific 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50399909
(CHEMBL2180945)Show SMILES CCCOc1ccc(cc1-c1nc(CC)c(CC)c(=O)[nH]1)S(=O)(=O)N1CCN(C)CC1 Show InChI InChI=1S/C22H32N4O4S/c1-5-14-30-20-9-8-16(31(28,29)26-12-10-25(4)11-13-26)15-18(20)21-23-19(7-3)17(6-2)22(27)24-21/h8-9,15H,5-7,10-14H2,1-4H3,(H,23,24,27) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
MMDB
PC cid
PC sid
PDB
UniChem
Similars
| PDB
Article
PubMed
| n/a | n/a | 1.60 | n/a | n/a | n/a | n/a | n/a | n/a |
Chinese Academy of Sciences
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant PDE5A by [3H]cGMP based tritium scintillation proximity assay |
J Med Chem 55: 10540-50 (2012)
Article DOI: 10.1021/jm301159y
BindingDB Entry DOI: 10.7270/Q2154J6G |
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
cGMP-specific 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50399909
(CHEMBL2180945)Show SMILES CCCOc1ccc(cc1-c1nc(CC)c(CC)c(=O)[nH]1)S(=O)(=O)N1CCN(C)CC1 Show InChI InChI=1S/C22H32N4O4S/c1-5-14-30-20-9-8-16(31(28,29)26-12-10-25(4)11-13-26)15-18(20)21-23-19(7-3)17(6-2)22(27)24-21/h8-9,15H,5-7,10-14H2,1-4H3,(H,23,24,27) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
MMDB
PC cid
PC sid
PDB
UniChem
Similars
| PDB
Article
PubMed
| n/a | n/a | 1.60 | n/a | n/a | n/a | n/a | n/a | n/a |
Chinese Academy of Sciences
Curated by ChEMBL
| Assay Description
Inhibition of N-terminal GST-tagged human PDE5A1 expressed in baculovirus infected sf9 cells using [3H]cGMP as substrate measured after 30 mins by sc... |
J Med Chem 62: 4979-4990 (2019)
Article DOI: 10.1021/acs.jmedchem.9b00123
BindingDB Entry DOI: 10.7270/Q2T72MWB |
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
cGMP-specific 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50525066
(CHEMBL4455861)Show SMILES CCCOc1ccc(NC(N)=O)cc1-c1nc(CC)c(CC)c(=O)[nH]1 Show InChI InChI=1S/C18H24N4O3/c1-4-9-25-15-8-7-11(20-18(19)24)10-13(15)16-21-14(6-3)12(5-2)17(23)22-16/h7-8,10H,4-6,9H2,1-3H3,(H3,19,20,24)(H,21,22,23) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 1.60 | n/a | n/a | n/a | n/a | n/a | n/a |
Chinese Academy of Sciences
Curated by ChEMBL
| Assay Description
Inhibition of N-terminal GST-tagged human PDE5A1 expressed in baculovirus infected sf9 cells using [3H]cGMP as substrate measured after 30 mins by sc... |
J Med Chem 62: 4979-4990 (2019)
Article DOI: 10.1021/acs.jmedchem.9b00123
BindingDB Entry DOI: 10.7270/Q2T72MWB |
More data for this
Ligand-Target Pair | |
cGMP-specific 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50525059
(CHEMBL4435186)Show SMILES CCCOc1ccc(NC(=O)C(=O)N2CCN(C)CC2)cc1-c1nc(CC)c(CC)c(=O)[nH]1 Show InChI InChI=1S/C24H33N5O4/c1-5-14-33-20-9-8-16(25-23(31)24(32)29-12-10-28(4)11-13-29)15-18(20)21-26-19(7-3)17(6-2)22(30)27-21/h8-9,15H,5-7,10-14H2,1-4H3,(H,25,31)(H,26,27,30) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 1.60 | n/a | n/a | n/a | n/a | n/a | n/a |
Chinese Academy of Sciences
Curated by ChEMBL
| Assay Description
Inhibition of N-terminal GST-tagged human PDE5A1 expressed in baculovirus infected sf9 cells using [3H]cGMP as substrate measured after 30 mins by sc... |
J Med Chem 62: 4979-4990 (2019)
Article DOI: 10.1021/acs.jmedchem.9b00123
BindingDB Entry DOI: 10.7270/Q2T72MWB |
More data for this
Ligand-Target Pair | |
cGMP-specific 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50525062
(CHEMBL4440789)Show SMILES CCCOc1ccc(cc1-c1nc(CC)c(CC)c(=O)[nH]1)S(=O)(=O)NCCC(O)=O Show InChI InChI=1S/C20H27N3O6S/c1-4-11-29-17-8-7-13(30(27,28)21-10-9-18(24)25)12-15(17)19-22-16(6-3)14(5-2)20(26)23-19/h7-8,12,21H,4-6,9-11H2,1-3H3,(H,24,25)(H,22,23,26) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 1.70 | n/a | n/a | n/a | n/a | n/a | n/a |
Chinese Academy of Sciences
Curated by ChEMBL
| Assay Description
Inhibition of N-terminal GST-tagged human PDE5A1 expressed in baculovirus infected sf9 cells using [3H]cGMP as substrate measured after 30 mins by sc... |
J Med Chem 62: 4979-4990 (2019)
Article DOI: 10.1021/acs.jmedchem.9b00123
BindingDB Entry DOI: 10.7270/Q2T72MWB |
More data for this
Ligand-Target Pair | |
cGMP-specific 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50525072
(CHEMBL4582221)Show SMILES CCCOc1ccc(NC(=O)N2CCCC2)cc1-c1nc(CC)c(CC)c(=O)[nH]1 Show InChI InChI=1S/C22H30N4O3/c1-4-13-29-19-10-9-15(23-22(28)26-11-7-8-12-26)14-17(19)20-24-18(6-3)16(5-2)21(27)25-20/h9-10,14H,4-8,11-13H2,1-3H3,(H,23,28)(H,24,25,27) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 1.90 | n/a | n/a | n/a | n/a | n/a | n/a |
Chinese Academy of Sciences
Curated by ChEMBL
| Assay Description
Inhibition of N-terminal GST-tagged human PDE5A1 expressed in baculovirus infected sf9 cells using [3H]cGMP as substrate measured after 30 mins by sc... |
J Med Chem 62: 4979-4990 (2019)
Article DOI: 10.1021/acs.jmedchem.9b00123
BindingDB Entry DOI: 10.7270/Q2T72MWB |
More data for this
Ligand-Target Pair | |
cGMP-specific 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50525070
(CHEMBL4539785)Show SMILES CCCOc1ccc(cc1-c1nc(CC)c(CC)c(=O)[nH]1)S(=O)(=O)N1CCC[C@H]1C(O)=O |r| Show InChI InChI=1S/C22H29N3O6S/c1-4-12-31-19-10-9-14(32(29,30)25-11-7-8-18(25)22(27)28)13-16(19)20-23-17(6-3)15(5-2)21(26)24-20/h9-10,13,18H,4-8,11-12H2,1-3H3,(H,27,28)(H,23,24,26)/t18-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
Chinese Academy of Sciences
Curated by ChEMBL
| Assay Description
Inhibition of N-terminal GST-tagged human PDE5A1 expressed in baculovirus infected sf9 cells using [3H]cGMP as substrate measured after 30 mins by sc... |
J Med Chem 62: 4979-4990 (2019)
Article DOI: 10.1021/acs.jmedchem.9b00123
BindingDB Entry DOI: 10.7270/Q2T72MWB |
More data for this
Ligand-Target Pair | |
cGMP-specific 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM14777
((2R,8R)-2-(2H-1,3-benzodioxol-5-yl)-6-methyl-3,6,1...)Show SMILES [H][C@]12Cc3c([nH]c4ccccc34)[C@H](N1C(=O)CN(C)C2=O)c1ccc2OCOc2c1 |r| Show InChI InChI=1S/C22H19N3O4/c1-24-10-19(26)25-16(22(24)27)9-14-13-4-2-3-5-15(13)23-20(14)21(25)12-6-7-17-18(8-12)29-11-28-17/h2-8,16,21,23H,9-11H2,1H3/t16-,21-/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
DrugBank
MCE
MMDB
PC cid
PC sid
PDB
UniChem
Patents
Similars
| DrugBank
MMDB
PDB
Article
PubMed
| n/a | n/a | 2.40 | n/a | n/a | n/a | n/a | n/a | n/a |
Chinese Academy of Sciences
Curated by ChEMBL
| Assay Description
Inhibition of N-terminal GST-tagged human PDE5A1 expressed in baculovirus infected sf9 cells using [3H]cGMP as substrate measured after 30 mins by sc... |
J Med Chem 62: 4979-4990 (2019)
Article DOI: 10.1021/acs.jmedchem.9b00123
BindingDB Entry DOI: 10.7270/Q2T72MWB |
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
cGMP-specific 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50399893
(CHEMBL2180948)Show SMILES CCCOc1ccc(cc1-c1nc(C(C)C)c(CC)c(=O)[nH]1)S(=O)(=O)N1CCN(C)CC1 Show InChI InChI=1S/C23H34N4O4S/c1-6-14-31-20-9-8-17(32(29,30)27-12-10-26(5)11-13-27)15-19(20)22-24-21(16(3)4)18(7-2)23(28)25-22/h8-9,15-16H,6-7,10-14H2,1-5H3,(H,24,25,28) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
Chinese Academy of Sciences
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant PDE5A by [3H]cGMP based tritium scintillation proximity assay |
J Med Chem 55: 10540-50 (2012)
Article DOI: 10.1021/jm301159y
BindingDB Entry DOI: 10.7270/Q2154J6G |
More data for this
Ligand-Target Pair | |
cGMP-specific 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM14390
(5-[2-ethoxy-5-(4-methyl-1-piperazinylsulfonyl)phen...)Show SMILES CCCc1nn(C)c2c1nc([nH]c2=O)-c1cc(ccc1OCC)S(=O)(=O)N1CCN(C)CC1 Show InChI InChI=1S/C22H30N6O4S/c1-5-7-17-19-20(27(4)25-17)22(29)24-21(23-19)16-14-15(8-9-18(16)32-6-2)33(30,31)28-12-10-26(3)11-13-28/h8-9,14H,5-7,10-13H2,1-4H3,(H,23,24,29) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
MCE
KEGG
MMDB
PC cid
PC sid
PDB
UniChem
Patents
Similars
| MMDB
PDB
Article
PubMed
| n/a | n/a | 3.90 | n/a | n/a | n/a | n/a | n/a | n/a |
Chinese Academy of Sciences
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant PDE5A by [3H]cGMP based tritium scintillation proximity assay |
J Med Chem 55: 10540-50 (2012)
Article DOI: 10.1021/jm301159y
BindingDB Entry DOI: 10.7270/Q2154J6G |
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
cGMP-specific 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM14390
(5-[2-ethoxy-5-(4-methyl-1-piperazinylsulfonyl)phen...)Show SMILES CCCc1nn(C)c2c1nc([nH]c2=O)-c1cc(ccc1OCC)S(=O)(=O)N1CCN(C)CC1 Show InChI InChI=1S/C22H30N6O4S/c1-5-7-17-19-20(27(4)25-17)22(29)24-21(23-19)16-14-15(8-9-18(16)32-6-2)33(30,31)28-12-10-26(3)11-13-28/h8-9,14H,5-7,10-13H2,1-4H3,(H,23,24,29) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
MCE
KEGG
MMDB
PC cid
PC sid
PDB
UniChem
Patents
Similars
| MMDB
PDB
Article
PubMed
| n/a | n/a | 4.30 | n/a | n/a | n/a | n/a | n/a | n/a |
Chinese Academy of Sciences
Curated by ChEMBL
| Assay Description
Inhibition of N-terminal GST-tagged human PDE5A1 expressed in baculovirus infected sf9 cells using [3H]cGMP as substrate measured after 30 mins by sc... |
J Med Chem 62: 4979-4990 (2019)
Article DOI: 10.1021/acs.jmedchem.9b00123
BindingDB Entry DOI: 10.7270/Q2T72MWB |
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
cGMP-specific 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50399894
(CHEMBL2180947)Show SMILES CCCOc1ccc(cc1-c1nc(C(C)C)c(C)c(=O)[nH]1)S(=O)(=O)N1CCN(C)CC1 Show InChI InChI=1S/C22H32N4O4S/c1-6-13-30-19-8-7-17(31(28,29)26-11-9-25(5)10-12-26)14-18(19)21-23-20(15(2)3)16(4)22(27)24-21/h7-8,14-15H,6,9-13H2,1-5H3,(H,23,24,27) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 4.80 | n/a | n/a | n/a | n/a | n/a | n/a |
Chinese Academy of Sciences
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant PDE5A by [3H]cGMP based tritium scintillation proximity assay |
J Med Chem 55: 10540-50 (2012)
Article DOI: 10.1021/jm301159y
BindingDB Entry DOI: 10.7270/Q2154J6G |
More data for this
Ligand-Target Pair | |
cGMP-specific 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50399891
(CHEMBL2180950)Show SMILES CCCOc1ccc(cc1-c1nc(CCC)c(CC)c(=O)[nH]1)S(=O)(=O)N1CCN(C)CC1 Show InChI InChI=1S/C23H34N4O4S/c1-5-8-20-18(7-3)23(28)25-22(24-20)19-16-17(9-10-21(19)31-15-6-2)32(29,30)27-13-11-26(4)12-14-27/h9-10,16H,5-8,11-15H2,1-4H3,(H,24,25,28) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 4.80 | n/a | n/a | n/a | n/a | n/a | n/a |
Chinese Academy of Sciences
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant PDE5A by [3H]cGMP based tritium scintillation proximity assay |
J Med Chem 55: 10540-50 (2012)
Article DOI: 10.1021/jm301159y
BindingDB Entry DOI: 10.7270/Q2154J6G |
More data for this
Ligand-Target Pair | |
cGMP-specific 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50525063
(CHEMBL4522391)Show InChI InChI=1S/C17H23N3O2/c1-4-9-22-15-8-7-11(18)10-13(15)16-19-14(6-3)12(5-2)17(21)20-16/h7-8,10H,4-6,9,18H2,1-3H3,(H,19,20,21) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 5.30 | n/a | n/a | n/a | n/a | n/a | n/a |
Chinese Academy of Sciences
Curated by ChEMBL
| Assay Description
Inhibition of N-terminal GST-tagged human PDE5A1 expressed in baculovirus infected sf9 cells using [3H]cGMP as substrate measured after 30 mins by sc... |
J Med Chem 62: 4979-4990 (2019)
Article DOI: 10.1021/acs.jmedchem.9b00123
BindingDB Entry DOI: 10.7270/Q2T72MWB |
More data for this
Ligand-Target Pair | |
cGMP-specific 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50399896
(CHEMBL2180943)Show SMILES CCCOc1ccc(cc1-c1nc(C(C)C)c(I)c(=O)[nH]1)S(=O)(=O)N1CCN(C)CC1 Show InChI InChI=1S/C21H29IN4O4S/c1-5-12-30-17-7-6-15(31(28,29)26-10-8-25(4)9-11-26)13-16(17)20-23-19(14(2)3)18(22)21(27)24-20/h6-7,13-14H,5,8-12H2,1-4H3,(H,23,24,27) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 5.80 | n/a | n/a | n/a | n/a | n/a | n/a |
Chinese Academy of Sciences
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant PDE5A by [3H]cGMP based tritium scintillation proximity assay |
J Med Chem 55: 10540-50 (2012)
Article DOI: 10.1021/jm301159y
BindingDB Entry DOI: 10.7270/Q2154J6G |
More data for this
Ligand-Target Pair | |
cGMP-specific 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50399898
(CHEMBL2180941)Show SMILES CCCOc1ccc(cc1-c1nc(C(C)C)c(Cl)c(=O)[nH]1)S(=O)(=O)N1CCN(C)CC1 Show InChI InChI=1S/C21H29ClN4O4S/c1-5-12-30-17-7-6-15(31(28,29)26-10-8-25(4)9-11-26)13-16(17)20-23-19(14(2)3)18(22)21(27)24-20/h6-7,13-14H,5,8-12H2,1-4H3,(H,23,24,27) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 6.60 | n/a | n/a | n/a | n/a | n/a | n/a |
Chinese Academy of Sciences
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant PDE5A by [3H]cGMP based tritium scintillation proximity assay |
J Med Chem 55: 10540-50 (2012)
Article DOI: 10.1021/jm301159y
BindingDB Entry DOI: 10.7270/Q2154J6G |
More data for this
Ligand-Target Pair | |
cGMP-specific 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50399897
(CHEMBL2180942)Show SMILES CCCOc1ccc(cc1-c1nc(C(C)C)c(Br)c(=O)[nH]1)S(=O)(=O)N1CCN(C)CC1 Show InChI InChI=1S/C21H29BrN4O4S/c1-5-12-30-17-7-6-15(31(28,29)26-10-8-25(4)9-11-26)13-16(17)20-23-19(14(2)3)18(22)21(27)24-20/h6-7,13-14H,5,8-12H2,1-4H3,(H,23,24,27) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 7.20 | n/a | n/a | n/a | n/a | n/a | n/a |
Chinese Academy of Sciences
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant PDE5A by [3H]cGMP based tritium scintillation proximity assay |
J Med Chem 55: 10540-50 (2012)
Article DOI: 10.1021/jm301159y
BindingDB Entry DOI: 10.7270/Q2154J6G |
More data for this
Ligand-Target Pair | |
cGMP-specific 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50399890
(CHEMBL2180951)Show SMILES CCOc1ccc(cc1-c1nc(C(C)C)c(Br)c(=O)[nH]1)S(=O)(=O)N1CCN(C)CC1 Show InChI InChI=1S/C20H27BrN4O4S/c1-5-29-16-7-6-14(30(27,28)25-10-8-24(4)9-11-25)12-15(16)19-22-18(13(2)3)17(21)20(26)23-19/h6-7,12-13H,5,8-11H2,1-4H3,(H,22,23,26) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 8.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Chinese Academy of Sciences
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant PDE5A by [3H]cGMP based tritium scintillation proximity assay |
J Med Chem 55: 10540-50 (2012)
Article DOI: 10.1021/jm301159y
BindingDB Entry DOI: 10.7270/Q2154J6G |
More data for this
Ligand-Target Pair | |
cGMP-specific 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50399910
(CHEMBL2180944)Show SMILES CCCOc1ccc(cc1-c1nc(CC)c(C)c(=O)[nH]1)S(=O)(=O)N1CCN(C)CC1 Show InChI InChI=1S/C21H30N4O4S/c1-5-13-29-19-8-7-16(30(27,28)25-11-9-24(4)10-12-25)14-17(19)20-22-18(6-2)15(3)21(26)23-20/h7-8,14H,5-6,9-13H2,1-4H3,(H,22,23,26) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 13 | n/a | n/a | n/a | n/a | n/a | n/a |
Chinese Academy of Sciences
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant PDE5A by [3H]cGMP based tritium scintillation proximity assay |
J Med Chem 55: 10540-50 (2012)
Article DOI: 10.1021/jm301159y
BindingDB Entry DOI: 10.7270/Q2154J6G |
More data for this
Ligand-Target Pair | |
cGMP-specific 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50399887
(CHEMBL2180954)Show SMILES CCOc1ccc(cc1-c1nc(C(C)C)c(Cl)c(=O)[nH]1)S(=O)(=O)N1CCN(C)CC1 Show InChI InChI=1S/C20H27ClN4O4S/c1-5-29-16-7-6-14(30(27,28)25-10-8-24(4)9-11-25)12-15(16)19-22-18(13(2)3)17(21)20(26)23-19/h6-7,12-13H,5,8-11H2,1-4H3,(H,22,23,26) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 13 | n/a | n/a | n/a | n/a | n/a | n/a |
Chinese Academy of Sciences
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant PDE5A by [3H]cGMP based tritium scintillation proximity assay |
J Med Chem 55: 10540-50 (2012)
Article DOI: 10.1021/jm301159y
BindingDB Entry DOI: 10.7270/Q2154J6G |
More data for this
Ligand-Target Pair | |
cGMP-specific 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50399892
(CHEMBL2180949)Show SMILES CCCOc1ccc(cc1-c1nc(C)c(CC)c(=O)[nH]1)S(=O)(=O)N1CCN(C)CC1 Show InChI InChI=1S/C21H30N4O4S/c1-5-13-29-19-8-7-16(30(27,28)25-11-9-24(4)10-12-25)14-18(19)20-22-15(3)17(6-2)21(26)23-20/h7-8,14H,5-6,9-13H2,1-4H3,(H,22,23,26) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 14 | n/a | n/a | n/a | n/a | n/a | n/a |
Chinese Academy of Sciences
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant PDE5A by [3H]cGMP based tritium scintillation proximity assay |
J Med Chem 55: 10540-50 (2012)
Article DOI: 10.1021/jm301159y
BindingDB Entry DOI: 10.7270/Q2154J6G |
More data for this
Ligand-Target Pair | |
Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'
(Homo sapiens (Human)) | BDBM50525060
(CHEMBL4462192)Show SMILES CCCOc1ccc(NC(=O)CN2CCN(C)CC2)cc1-c1nc(CC)c(CC)c(=O)[nH]1 Show InChI InChI=1S/C24H35N5O3/c1-5-14-32-21-9-8-17(25-22(30)16-29-12-10-28(4)11-13-29)15-19(21)23-26-20(7-3)18(6-2)24(31)27-23/h8-9,15H,5-7,10-14,16H2,1-4H3,(H,25,30)(H,26,27,31) | UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| Purchase
MCE
PC cid
PC sid
PDB
UniChem
| Article
PubMed
| n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a | n/a |
Chinese Academy of Sciences
Curated by ChEMBL
| Assay Description
Inhibition of N-terminal GST-tagged human PDE6C expressed in baculovirus infected sf9 cells using [3H]cGMP as substrate measured after 30 mins by sci... |
J Med Chem 62: 4979-4990 (2019)
Article DOI: 10.1021/acs.jmedchem.9b00123
BindingDB Entry DOI: 10.7270/Q2T72MWB |
More data for this
Ligand-Target Pair | |
Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A
(Homo sapiens (Human)) | BDBM14777
((2R,8R)-2-(2H-1,3-benzodioxol-5-yl)-6-methyl-3,6,1...)Show SMILES [H][C@]12Cc3c([nH]c4ccccc34)[C@H](N1C(=O)CN(C)C2=O)c1ccc2OCOc2c1 |r| Show InChI InChI=1S/C22H19N3O4/c1-24-10-19(26)25-16(22(24)27)9-14-13-4-2-3-5-15(13)23-20(14)21(25)12-6-7-17-18(8-12)29-11-28-17/h2-8,16,21,23H,9-11H2,1H3/t16-,21-/m1/s1 | KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
DrugBank
MCE
MMDB
PC cid
PC sid
PDB
UniChem
Patents
Similars
| DrugBank
Article
PubMed
| n/a | n/a | 22 | n/a | n/a | n/a | n/a | n/a | n/a |
Chinese Academy of Sciences
Curated by ChEMBL
| Assay Description
Inhibition of N-terminal GST-tagged human PDE11A4 expressed in baculovirus infected sf9 cells using [3H]cGMP as substrate measured after 30 mins by s... |
J Med Chem 62: 4979-4990 (2019)
Article DOI: 10.1021/acs.jmedchem.9b00123
BindingDB Entry DOI: 10.7270/Q2T72MWB |
More data for this
Ligand-Target Pair | |
cGMP-specific 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50399903
(CHEMBL2180659)Show SMILES CCCOc1ccc(cc1-c1nc(cc(=O)[nH]1)C(C)C)S(=O)(=O)N1CCN(C)CC1 Show InChI InChI=1S/C21H30N4O4S/c1-5-12-29-19-7-6-16(30(27,28)25-10-8-24(4)9-11-25)13-17(19)21-22-18(15(2)3)14-20(26)23-21/h6-7,13-15H,5,8-12H2,1-4H3,(H,22,23,26) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 32 | n/a | n/a | n/a | n/a | n/a | n/a |
Chinese Academy of Sciences
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant PDE5A by [3H]cGMP based tritium scintillation proximity assay |
J Med Chem 55: 10540-50 (2012)
Article DOI: 10.1021/jm301159y
BindingDB Entry DOI: 10.7270/Q2154J6G |
More data for this
Ligand-Target Pair | |
cGMP-specific 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50399895
(CHEMBL2180946)Show SMILES CCCOc1ccc(cc1-c1nc(CC)c(CCC)c(=O)[nH]1)S(=O)(=O)N1CCN(C)CC1 Show InChI InChI=1S/C23H34N4O4S/c1-5-8-18-20(7-3)24-22(25-23(18)28)19-16-17(9-10-21(19)31-15-6-2)32(29,30)27-13-11-26(4)12-14-27/h9-10,16H,5-8,11-15H2,1-4H3,(H,24,25,28) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 34 | n/a | n/a | n/a | n/a | n/a | n/a |
Chinese Academy of Sciences
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant PDE5A by [3H]cGMP based tritium scintillation proximity assay |
J Med Chem 55: 10540-50 (2012)
Article DOI: 10.1021/jm301159y
BindingDB Entry DOI: 10.7270/Q2154J6G |
More data for this
Ligand-Target Pair | |
Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'
(Homo sapiens (Human)) | BDBM14390
(5-[2-ethoxy-5-(4-methyl-1-piperazinylsulfonyl)phen...)Show SMILES CCCc1nn(C)c2c1nc([nH]c2=O)-c1cc(ccc1OCC)S(=O)(=O)N1CCN(C)CC1 Show InChI InChI=1S/C22H30N6O4S/c1-5-7-17-19-20(27(4)25-17)22(29)24-21(23-19)16-14-15(8-9-18(16)32-6-2)33(30,31)28-12-10-26(3)11-13-28/h8-9,14H,5-7,10-13H2,1-4H3,(H,23,24,29) | UniProtKB/SwissProt
antibodypedia
GoogleScholar
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| Purchase
CHEMBL
MCE
KEGG
MMDB
PC cid
PC sid
PDB
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 36 | n/a | n/a | n/a | n/a | n/a | n/a |
Chinese Academy of Sciences
Curated by ChEMBL
| Assay Description
Inhibition of N-terminal GST-tagged human PDE6C expressed in baculovirus infected sf9 cells using [3H]cGMP as substrate measured after 30 mins by sci... |
J Med Chem 62: 4979-4990 (2019)
Article DOI: 10.1021/acs.jmedchem.9b00123
BindingDB Entry DOI: 10.7270/Q2T72MWB |
More data for this
Ligand-Target Pair | |
Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'
(Homo sapiens (Human)) | BDBM14390
(5-[2-ethoxy-5-(4-methyl-1-piperazinylsulfonyl)phen...)Show SMILES CCCc1nn(C)c2c1nc([nH]c2=O)-c1cc(ccc1OCC)S(=O)(=O)N1CCN(C)CC1 Show InChI InChI=1S/C22H30N6O4S/c1-5-7-17-19-20(27(4)25-17)22(29)24-21(23-19)16-14-15(8-9-18(16)32-6-2)33(30,31)28-12-10-26(3)11-13-28/h8-9,14H,5-7,10-13H2,1-4H3,(H,23,24,29) | UniProtKB/SwissProt
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| n/a | n/a | 39 | n/a | n/a | n/a | n/a | n/a | n/a |
Chinese Academy of Sciences
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant PDE6C at 1 uM by [3H]cGMP based tritium scintillation proximity assay |
J Med Chem 55: 10540-50 (2012)
Article DOI: 10.1021/jm301159y
BindingDB Entry DOI: 10.7270/Q2154J6G |
More data for this
Ligand-Target Pair | |
cGMP-specific 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50399889
(CHEMBL2180952)Show SMILES CCCCOc1ccc(cc1-c1nc(C(C)C)c(Br)c(=O)[nH]1)S(=O)(=O)N1CCN(C)CC1 Show InChI InChI=1S/C22H31BrN4O4S/c1-5-6-13-31-18-8-7-16(32(29,30)27-11-9-26(4)10-12-27)14-17(18)21-24-20(15(2)3)19(23)22(28)25-21/h7-8,14-15H,5-6,9-13H2,1-4H3,(H,24,25,28) | PDB
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| n/a | n/a | 41 | n/a | n/a | n/a | n/a | n/a | n/a |
Chinese Academy of Sciences
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant PDE5A by [3H]cGMP based tritium scintillation proximity assay |
J Med Chem 55: 10540-50 (2012)
Article DOI: 10.1021/jm301159y
BindingDB Entry DOI: 10.7270/Q2154J6G |
More data for this
Ligand-Target Pair | |
Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'
(Homo sapiens (Human)) | BDBM50399909
(CHEMBL2180945)Show SMILES CCCOc1ccc(cc1-c1nc(CC)c(CC)c(=O)[nH]1)S(=O)(=O)N1CCN(C)CC1 Show InChI InChI=1S/C22H32N4O4S/c1-5-14-30-20-9-8-16(31(28,29)26-12-10-25(4)11-13-26)15-18(20)21-23-19(7-3)17(6-2)22(27)24-21/h8-9,15H,5-7,10-14H2,1-4H3,(H,23,24,27) | UniProtKB/SwissProt
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| n/a | n/a | 46 | n/a | n/a | n/a | n/a | n/a | n/a |
Chinese Academy of Sciences
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant PDE6C at 1 uM by [3H]cGMP based tritium scintillation proximity assay |
J Med Chem 55: 10540-50 (2012)
Article DOI: 10.1021/jm301159y
BindingDB Entry DOI: 10.7270/Q2154J6G |
More data for this
Ligand-Target Pair | |
cGMP-specific 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50399888
(CHEMBL2180953)Show SMILES CCCCCCOc1ccc(cc1-c1nc(C(C)C)c(Br)c(=O)[nH]1)S(=O)(=O)N1CCN(C)CC1 Show InChI InChI=1S/C24H35BrN4O4S/c1-5-6-7-8-15-33-20-10-9-18(34(31,32)29-13-11-28(4)12-14-29)16-19(20)23-26-22(17(2)3)21(25)24(30)27-23/h9-10,16-17H,5-8,11-15H2,1-4H3,(H,26,27,30) | PDB
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PubMed
| n/a | n/a | 58 | n/a | n/a | n/a | n/a | n/a | n/a |
Chinese Academy of Sciences
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant PDE5A by [3H]cGMP based tritium scintillation proximity assay |
J Med Chem 55: 10540-50 (2012)
Article DOI: 10.1021/jm301159y
BindingDB Entry DOI: 10.7270/Q2154J6G |
More data for this
Ligand-Target Pair | |
cGMP-specific 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50399904
(CHEMBL2180658)Show SMILES CCCOc1ccc(cc1-c1nc(CCC)cc(=O)[nH]1)S(=O)(=O)N1CCN(C)CC1 Show InChI InChI=1S/C21H30N4O4S/c1-4-6-16-14-20(26)23-21(22-16)18-15-17(7-8-19(18)29-13-5-2)30(27,28)25-11-9-24(3)10-12-25/h7-8,14-15H,4-6,9-13H2,1-3H3,(H,22,23,26) | PDB
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Reactome pathway
KEGG
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UniChem
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PubMed
| n/a | n/a | 65 | n/a | n/a | n/a | n/a | n/a | n/a |
Chinese Academy of Sciences
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant PDE5A by [3H]cGMP based tritium scintillation proximity assay |
J Med Chem 55: 10540-50 (2012)
Article DOI: 10.1021/jm301159y
BindingDB Entry DOI: 10.7270/Q2154J6G |
More data for this
Ligand-Target Pair | |
cGMP-specific 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50399905
(CHEMBL2180657)Show SMILES CCCOc1ccc(cc1-c1nc(C)cc(=O)[nH]1)S(=O)(=O)N1CCN(C)CC1 Show InChI InChI=1S/C19H26N4O4S/c1-4-11-27-17-6-5-15(28(25,26)23-9-7-22(3)8-10-23)13-16(17)19-20-14(2)12-18(24)21-19/h5-6,12-13H,4,7-11H2,1-3H3,(H,20,21,24) | PDB
MMDB
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KEGG
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| CHEMBL
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PC sid
UniChem
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PubMed
| n/a | n/a | 71 | n/a | n/a | n/a | n/a | n/a | n/a |
Chinese Academy of Sciences
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant PDE5A by [3H]cGMP based tritium scintillation proximity assay |
J Med Chem 55: 10540-50 (2012)
Article DOI: 10.1021/jm301159y
BindingDB Entry DOI: 10.7270/Q2154J6G |
More data for this
Ligand-Target Pair | |
cGMP-specific 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50399902
(CHEMBL2180660)Show SMILES CCCOc1ccc(cc1-c1nc(CC(C)C)cc(=O)[nH]1)S(=O)(=O)N1CCN(C)CC1 Show InChI InChI=1S/C22H32N4O4S/c1-5-12-30-20-7-6-18(31(28,29)26-10-8-25(4)9-11-26)15-19(20)22-23-17(13-16(2)3)14-21(27)24-22/h6-7,14-16H,5,8-13H2,1-4H3,(H,23,24,27) | PDB
MMDB
Reactome pathway
KEGG
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| CHEMBL
PC cid
PC sid
UniChem
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PubMed
| n/a | n/a | 88 | n/a | n/a | n/a | n/a | n/a | n/a |
Chinese Academy of Sciences
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant PDE5A by [3H]cGMP based tritium scintillation proximity assay |
J Med Chem 55: 10540-50 (2012)
Article DOI: 10.1021/jm301159y
BindingDB Entry DOI: 10.7270/Q2154J6G |
More data for this
Ligand-Target Pair | |
cGMP-specific 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50399901
(CHEMBL2180661)Show SMILES CCCOc1ccc(cc1-c1nc(cc(=O)[nH]1)-c1ccccc1)S(=O)(=O)N1CCN(C)CC1 Show InChI InChI=1S/C24H28N4O4S/c1-3-15-32-22-10-9-19(33(30,31)28-13-11-27(2)12-14-28)16-20(22)24-25-21(17-23(29)26-24)18-7-5-4-6-8-18/h4-10,16-17H,3,11-15H2,1-2H3,(H,25,26,29) | PDB
MMDB
Reactome pathway
KEGG
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| CHEMBL
PC cid
PC sid
UniChem
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| Article
PubMed
| n/a | n/a | 104 | n/a | n/a | n/a | n/a | n/a | n/a |
Chinese Academy of Sciences
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant PDE5A by [3H]cGMP based tritium scintillation proximity assay |
J Med Chem 55: 10540-50 (2012)
Article DOI: 10.1021/jm301159y
BindingDB Entry DOI: 10.7270/Q2154J6G |
More data for this
Ligand-Target Pair | |
cGMP-specific 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50399900
(CHEMBL2180662)Show SMILES CCCOc1ccc(cc1-c1nc(cc(=O)[nH]1)C(F)(F)F)S(=O)(=O)N1CCN(C)CC1 Show InChI InChI=1S/C19H23F3N4O4S/c1-3-10-30-15-5-4-13(31(28,29)26-8-6-25(2)7-9-26)11-14(15)18-23-16(19(20,21)22)12-17(27)24-18/h4-5,11-12H,3,6-10H2,1-2H3,(H,23,24,27) | PDB
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Reactome pathway
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PubMed
| n/a | n/a | 312 | n/a | n/a | n/a | n/a | n/a | n/a |
Chinese Academy of Sciences
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant PDE5A by [3H]cGMP based tritium scintillation proximity assay |
J Med Chem 55: 10540-50 (2012)
Article DOI: 10.1021/jm301159y
BindingDB Entry DOI: 10.7270/Q2154J6G |
More data for this
Ligand-Target Pair | |
Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'
(Homo sapiens (Human)) | BDBM14777
((2R,8R)-2-(2H-1,3-benzodioxol-5-yl)-6-methyl-3,6,1...)Show SMILES [H][C@]12Cc3c([nH]c4ccccc34)[C@H](N1C(=O)CN(C)C2=O)c1ccc2OCOc2c1 |r| Show InChI InChI=1S/C22H19N3O4/c1-24-10-19(26)25-16(22(24)27)9-14-13-4-2-3-5-15(13)23-20(14)21(25)12-6-7-17-18(8-12)29-11-28-17/h2-8,16,21,23H,9-11H2,1H3/t16-,21-/m1/s1 | UniProtKB/SwissProt
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| n/a | n/a | 402 | n/a | n/a | n/a | n/a | n/a | n/a |
Chinese Academy of Sciences
Curated by ChEMBL
| Assay Description
Inhibition of N-terminal GST-tagged human PDE6C expressed in baculovirus infected sf9 cells using [3H]cGMP as substrate measured after 30 mins by sci... |
J Med Chem 62: 4979-4990 (2019)
Article DOI: 10.1021/acs.jmedchem.9b00123
BindingDB Entry DOI: 10.7270/Q2T72MWB |
More data for this
Ligand-Target Pair | |
cGMP-specific 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50399906
(CHEMBL2180656)Show SMILES CCCOc1ccc(cc1-c1nc(NC(C)=O)cc(=O)[nH]1)S(=O)(=O)N1CCN(C)CC1 Show InChI InChI=1S/C20H27N5O5S/c1-4-11-30-17-6-5-15(31(28,29)25-9-7-24(3)8-10-25)12-16(17)20-22-18(21-14(2)26)13-19(27)23-20/h5-6,12-13H,4,7-11H2,1-3H3,(H2,21,22,23,26,27) | PDB
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PubMed
| n/a | n/a | 450 | n/a | n/a | n/a | n/a | n/a | n/a |
Chinese Academy of Sciences
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant PDE5A by [3H]cGMP based tritium scintillation proximity assay |
J Med Chem 55: 10540-50 (2012)
Article DOI: 10.1021/jm301159y
BindingDB Entry DOI: 10.7270/Q2154J6G |
More data for this
Ligand-Target Pair | |
Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A/1B/1C
(Homo sapiens (Human)) | BDBM14390
(5-[2-ethoxy-5-(4-methyl-1-piperazinylsulfonyl)phen...)Show SMILES CCCc1nn(C)c2c1nc([nH]c2=O)-c1cc(ccc1OCC)S(=O)(=O)N1CCN(C)CC1 Show InChI InChI=1S/C22H30N6O4S/c1-5-7-17-19-20(27(4)25-17)22(29)24-21(23-19)16-14-15(8-9-18(16)32-6-2)33(30,31)28-12-10-26(3)11-13-28/h8-9,14H,5-7,10-13H2,1-4H3,(H,23,24,29) | PDB
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| n/a | n/a | 819 | n/a | n/a | n/a | n/a | n/a | n/a |
Chinese Academy of Sciences
Curated by ChEMBL
| Assay Description
Inhibition of N-terminal GST-tagged human PDE1 expressed in baculovirus infected sf9 cells using [3H]cAMP as substrate measured after 30 mins by scin... |
J Med Chem 62: 4979-4990 (2019)
Article DOI: 10.1021/acs.jmedchem.9b00123
BindingDB Entry DOI: 10.7270/Q2T72MWB |
More data for this
Ligand-Target Pair | |
Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A
(Homo sapiens (Human)) | BDBM50525060
(CHEMBL4462192)Show SMILES CCCOc1ccc(NC(=O)CN2CCN(C)CC2)cc1-c1nc(CC)c(CC)c(=O)[nH]1 Show InChI InChI=1S/C24H35N5O3/c1-5-14-32-21-9-8-17(25-22(30)16-29-12-10-28(4)11-13-29)15-19(21)23-26-20(7-3)18(6-2)24(31)27-23/h8-9,15H,5-7,10-14,16H2,1-4H3,(H,25,30)(H,26,27,31) | KEGG
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| n/a | n/a | 998 | n/a | n/a | n/a | n/a | n/a | n/a |
Chinese Academy of Sciences
Curated by ChEMBL
| Assay Description
Inhibition of N-terminal GST-tagged human PDE11A4 expressed in baculovirus infected sf9 cells using [3H]cGMP as substrate measured after 30 mins by s... |
J Med Chem 62: 4979-4990 (2019)
Article DOI: 10.1021/acs.jmedchem.9b00123
BindingDB Entry DOI: 10.7270/Q2T72MWB |
More data for this
Ligand-Target Pair | |
cGMP-specific 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50399911
(CHEMBL2180955)Show SMILES CCCOc1ccc(cc1-c1nc2CCCc2c(=O)[nH]1)S(=O)(=O)N1CCN(C)CC1 Show InChI InChI=1S/C21H28N4O4S/c1-3-13-29-19-8-7-15(30(27,28)25-11-9-24(2)10-12-25)14-17(19)20-22-18-6-4-5-16(18)21(26)23-20/h7-8,14H,3-6,9-13H2,1-2H3,(H,22,23,26) | PDB
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| PDB
Article
PubMed
| n/a | n/a | >1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Chinese Academy of Sciences
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant PDE5A by [3H]cGMP based tritium scintillation proximity assay |
J Med Chem 55: 10540-50 (2012)
Article DOI: 10.1021/jm301159y
BindingDB Entry DOI: 10.7270/Q2154J6G |
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
cGMP-specific 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50399899
(CHEMBL2180663)Show SMILES CCCOc1ccc(cc1-c1nc(CC)c(NC(C)=O)c(=O)[nH]1)S(=O)(=O)N1CCN(C)CC1 Show InChI InChI=1S/C22H31N5O5S/c1-5-13-32-19-8-7-16(33(30,31)27-11-9-26(4)10-12-27)14-17(19)21-24-18(6-2)20(22(29)25-21)23-15(3)28/h7-8,14H,5-6,9-13H2,1-4H3,(H,23,28)(H,24,25,29) | PDB
MMDB
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PC cid
PC sid
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PubMed
| n/a | n/a | >2.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Chinese Academy of Sciences
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant PDE5A by [3H]cGMP based tritium scintillation proximity assay |
J Med Chem 55: 10540-50 (2012)
Article DOI: 10.1021/jm301159y
BindingDB Entry DOI: 10.7270/Q2154J6G |
More data for this
Ligand-Target Pair | |
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